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Isoforms Recommended:	CB2

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CB2

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By Targets:	5-HT Receptor (1) Biochemical Assay Reagents (1) Cannabinoid Receptor (77) Cholinesterase (ChE) (2) Cytochrome P450 (1) Endogenous Metabolite (12) FAAH (4) Fluorescent Dye (1) GlyT (1) GPR55 (4) HIF/HIF Prolyl-Hydroxylase (1) MAGL (1) PDHK (1) PPAR (1) TRP Channel (2)
By Research Areas:	Cancer (12) Infection (5) Inflammation/Immunology (23) Metabolic Disease (9) Neurological Disease (55)
Click Chemistry:	Azide (2)

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CB2 modulator 1	Cannabinoid Receptor	Neurological Disease Inflammation/Immunology
CB2 modulator 1 (compound 130) is a potent *CB2* modulator. CB2 modulator 1 has the potential for immunedisorders, inflammation, osteoporosis, renal ischemia .

CB2 receptor antagonist 2	Others	Others
CB2 receptor antagonist 2 (compound 39) is a potent antagonist of *CB2* with an IC₅₀ value of 0.33 μM. CB2 receptor antagonist 2 has strong interactions with L17, W6.48, V6.51, and C7.42 .

CB2 receptor agonist 2	Cannabinoid Receptor	Neurological Disease
CB2 receptor agonist 2 is a potent and selective agonist for the *CB2* (cannabinoid type 2) receptor with a K_i of 8.5 nM. CB2 receptor agonist 2 has high affinity and selectivity for *CB2* .

CB2 receptor antagonist 5	Cannabinoid Receptor	Others
CB2 receptor antagonist 5 (compound 4A) is a ligand of CB2 receptor with antagonist effect .

CB2 receptor agonist 6	Cannabinoid Receptor	Neurological Disease Inflammation/Immunology
CB2 receptor agonist 6 (compound 70) is an agonist of *CB2R, with EC₅₀* of 162 nM. The IC₅₀ values of CB2 receptor agonist 6 are 4.83 μM for CB1R and 0.88 μM for *CB2R. CB2* receptor agonist 6 is a neuroprotective agent that can be used for the reseach of neurological disease .

CB2 receptor antagonist 3	Cannabinoid Receptor	Neurological Disease
CB2 receptor antagonist 3 (compound (S)-1) is an inverse agonist of the cannabinoid receptor CB2R with Kd=39 nM. CB2 receptor antagonist 3 can be used as a tool to synthesize a variety of CB2R probes .

CB2 PET Radioligand 1	Cannabinoid Receptor	Neurological Disease
CB2 PET Radioligand 1 (compound [18F]9) is a PET Radioligand targeting to hCB2 (Ki=7.7 nM). CB2 PET Radioligand 1 is prepared with Cu-mediated 18F-fluorination. CB2 PET Radioligand 1 shows high brain uptake in a murine model of neuroinflammation .

CB2 receptor agonist 3 GP2a	Cannabinoid Receptor	Cancer
CB2 receptor agonist 3 is a robust and selective *CB2* cannabinoid agonist with K_is of 7.6 and 900 nM for CB2 and CB1, respectively. CB2 receptor agonist 3 significantly increases P-ERK 1/2 expression in HL-60 cells .

CB2 receptor antagonist 1	Cannabinoid Receptor	Others
Hexyl resorcinol derivative 29 has been proved to be a CB2 selective competitive antagonist / reverse agonist with good potency. Olivanol and 5- (2-methyloctane-2-yl) resorcinol derivatives 23 and 24 showed significant antinociceptive activity. Compound 24 was shown to activate cannabinoid and TRPV1 receptors.

CB2R-IN-1	Cannabinoid Receptor	Neurological Disease
CB2R-IN-1 is a potent cannabinoid CB₂ receptor inverse agonist with a K_i of 0.9 nM.

CB2-H	Fluorescent Dye	Others
CB2-H is a dual-channel fluorescent probe for the simultaneous detection of HOCl and ONOO ^-. CB2-H enables the concurrent detection of HOCl and ONOO ^- at two independent channels without spectral cross-interference and can be applied for dual-channel fluorescence imaging of endogenously produced HOCl and ONOO ^- in living cells and zebrafish under different stimulants .

CB2R/5-HT1AR agonist 1	Cannabinoid Receptor 5-HT Receptor	Neurological Disease
CB2R/5-HT1AR agonist 1 (Compound 2o) is an orally active partial agonist of the *CB₂* receptor (EC₅₀=479.6 nM). CB2R/5-HT1AR agonist 1 is a full agonist of 5-HT_1A receptor (EC₅₀=2.7 μM). CB2R/5-HT1AR agonist 1 exhibits anti-anxiety and anti-depressive effects. CB2R/5-HT1AR agonist 1 possesses favorable pharmacokinetic properties .

CB2R agonist 2	Cannabinoid Receptor	Neurological Disease
CB2R agonist 2 (compound cis-17-para) is a *CB2R* agonist .

CB2R/FAAH modulator-1	Cannabinoid Receptor FAAH	Inflammation/Immunology
CB2R/FAAH modulator-1 is a cannabinoid type 2 receptor (CB2R) full agonist with K_is of 14.8 nM and 241.3 nM for CB2R and CB1R, respectively. CB2R/FAAH modulator-1 is a fatty acid amide hydrolase (FAAH) inhibitor with an IC₅₀ of 4 μM. CB2R/FAAH modulator-1 decreases pro-inflammatory and increases anti-inflammatory cytokines production .

CB2R PAM	Cannabinoid Receptor	Neurological Disease
CB2R PAM is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator. CB2R PAM displays antinociceptive activity in vivo in an experimental mouse model of neuropathic pain .

CB2R/FAAH modulator-3	FAAH Cannabinoid Receptor	Infection Neurological Disease Inflammation/Immunology Cancer
CB2R/FAAH modulator-3 (compound 27) is a dual targeting modulator that acts as a *CB2R* agonist and FAAH inhibitor. The K_i values for CB2R/FAAH modulator-3 are 20.1 and 67.6 nM for CB2R and CB1R, respectively, and the IC₅₀ value for FAAH is 3.4 μM. CB2R/FAAH modulator-3 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection .

CB2R/FAAH modulator-2	FAAH Cannabinoid Receptor	Infection Neurological Disease Inflammation/Immunology Cancer
CB2R/FAAH modulator-2 (compound 26) is a dual targeting modulator that acts as a *CB2R* agonist and FAAH inhibitor. The K_i values for CB2R/FAAH modulator-2 are 10.8 and 152.9 nM for CB2R and CB1R, respectively, and the IC₅₀ value for FAAH is 6.2 μM. CB2R/FAAH modulator-2 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection .

CB2R antagonist 3	Cannabinoid Receptor	Inflammation/Immunology
CB2R antagonist 3 is a selective antagonist of cannabinoid type 2 receptor (CB2R). CB2R antagonist 3 has high affinity for human CB2R and specific selectivity for CB1R. CB2R antagonist 3 can be combined with CB65 (HY-110047), the activator of CB2R. CB2R antagonist 3 effectively up-regulates the expression of anti-inflammatory cytokines and down-regulates the expression of pro-inflammatory cytokines .

CB2R probe 1	Cannabinoid Receptor	Cancer
CB2R probe 1 is a safe and green CB2R (cannabinoid 2 receptor) fluorescent probe with an K_i of 130 nM. CB2R probe 1 shows low cytotoxicity in cancer cells .

CB2R agonist 1	Cannabinoid Receptor	Inflammation/Immunology
CB2R agonist 1 is a selective ligand of cannabinoid receptor subtype 2 (CB2R) with an EC₅₀ value of 0.56 µM. CB2R agonist 1 has high affinity and excellent selectivity for human *CB2R* and CB1R respectively. CB2R agonist 1 regulates the production of pro-inflammatory cytokines and anti-inflammatory cytokines and play an immunomodulatory role .

CB2R agonist 3	Cannabinoid Receptor	Inflammation/Immunology
CB2R agonist 3 is an agonist of cannabinoid receptor 2 (CB2R), with EC₅₀ of 0.37μM that plays an important role in immune system .

Tetrahydromagnolol Magnolignan	Cannabinoid Receptor GPR55	Inflammation/Immunology
Tetrahydromagnolol (Magnolignan), a main metabolite of Magnolol, is a potent and selective *cannabinoid CB2* receptor agonist with an EC₅₀ of 170 nM and a K_i** of 416 nM. Tetrahydromagnolol possesses 20-fold more selective for CB2 receptor than CB1 receptor. Tetrahydromagnolol is also a weak GPR55 receptor antagonist .

CB65	Cannabinoid Receptor	Inflammation/Immunology
CB65 is a potent and high affinity *CB2* selective agonist with a K_i value of 3.3 nM. CB65 exhibits a K_i of >1000 nM for CB1 receptor .

PSB-SB1202	Cannabinoid Receptor	Neurological Disease
PSB-SB1202 (Compound 21a) is a phenyl coumarin compound. PSB-SB1202 is a *CB1/CB2* agonist with EC₅₀ values of 56 and 14 nM, and K_i values of 32 and 49 nM, respectively .

S-777469	Cannabinoid Receptor	Neurological Disease
S-777469 is a selective and orally available cannabinoid type 2 receptor *(CB2)* agonist with a K_i of 36 nM. S-777469 significantly suppresses compound 48/80-induced scratching behavior in mice in a dose-dependent manner. S-777469 produces its antipruritic effects by inhibiting itch signal transmission through CB2 agonism ^[2].

AZD1940	Cannabinoid Receptor	Neurological Disease
AZD1940 is an orally active, high affinity *cannabinoid CB1/CB2* receptor agonist with pK_i values of 7.93 and 9.06 for human CB1R and CB2R**, respectively. AZD1940 shows a robust analgesia action ^[2].

PF-03550096	Cannabinoid Receptor	Neurological Disease
PF-03550096 is an orally active synthetic cannabinoid (CB) that selectively targets peripheral *CB2* receptors with a K_i value of 7.9 nM. PF-03550096 has analgesic activity .

A-836339	Cannabinoid Receptor	Neurological Disease
A-836339 is a cannabinoid CB2 receptor-selective agonist; exhibits high potencies at CB(2) and selectivity over CB(1) receptors.

GW405833 hydrochloride L768242 hydrochloride	Cannabinoid Receptor	Neurological Disease
GW405833 hydrochloride is a potent and selective **cannabinoid-2 (CB2)** receptor agonist (EC₅₀ = 0.65 nM; maximum inhibition = 44.6%). GW405833 hydrochloride produces potent antihyperalgesic effects in several rodent models of pain ^[2] .

BML-190 Indomethacin morpholinylamide; IMMA	Cannabinoid Receptor	Cancer
BML-190(IMMA) is a potent and selective CB2 receptor ligand (Ki values are 435 nM and > 2 μM for CB2 and CB1 respectively).

GW842166X	Cannabinoid Receptor	Neurological Disease Inflammation/Immunology
GW842166X is a potent and selective cannabinoid receptor 2 (CB2) agonist with IC₅₀ values of 63 and 91 nM for human and rat CB2, respectively.

MDA 19 1 Publications Verification	Cannabinoid Receptor	Neurological Disease
MDA 19 is a potent and selective agonist of human cannabinoid receptor 2 (CB2), with a K_i of 43.3 nM. MDA 19 has antiallodynic effects in a rat model of neuropathic pain and does not affect rat locomotor activity ^[2].

CB1/2 agonist 3	Cannabinoid Receptor	Neurological Disease
CB1/2 agonist 3 (compound 52), a potent non-selective cannabinoid ligand, is a *CB1/CB2* (cannabinoid receptor) competitive agonist. CB1/2 agonist 3 acts on hCB1 and hCB2 with K_i values of 5.9 nM and 3.5 nM, respectively .

Bay 59-3074	Cannabinoid Receptor	Cancer
Bay 59-3074 is a selective cannabinoid CB₁/CB₂ receptor partial agonist with K_i values of 48.3 and 45.5 nM at human CB₁ and *CB₂* receptors, respectively. Bay 59-3074 has analgesic properties .

β-Caryophyllene (-)-(E)-Caryophyllene; (−)-β-caryophyllene; (−)-trans-Caryophyllene	Cannabinoid Receptor Endogenous Metabolite	Infection Neurological Disease Cancer
β-Caryophyllene is a CB2 receptor agonist.

GP1a	Cannabinoid Receptor	Neurological Disease Inflammation/Immunology
GP1a is a potent agonist of cannabinoid receptor 2 (CB2). Gp1a is beneficial to skin wound healing. GP1a inhibits inflammation and fibrogenesis while promoting re-epithelialization .

SCH 336 SCH-225336	Cannabinoid Receptor	Inflammation/Immunology
SCH 336 is a potent, selective, inverse and orally active *CB2* agonist. SCH 336 inhibits BaF3/CB2 migration. SCH 336 significantly inhibits the migration of leukocytes in vivo. SCH 336 blocks ovalbumin-induced lung eosinophilia in mice .

BAY 38-7271	Cannabinoid Receptor	Neurological Disease
BAY 38-7271 is selective and highly potent and cannabinoid CB₁/CB₂ receptor agonist, with K_is of 1.85 nM and 5.96 nM for recombinant human CB₁ receptor and CB₂ receptor, respectively. BAY 38-7271 has strong neuroprotective properties .

SR144528 5 Publications Verification	Cannabinoid Receptor	Neurological Disease
SR144528 is a potent and selective CB2 receptor antagonist with a K_i of 0.6 nM.

PGN36	Cannabinoid Receptor	Inflammation/Immunology
PGN36 (Compound 18) is a selective cannabinoid CB₂ receptor (CB₂R) antagonist with a K_i of 0.09 µM .

Tedalinab GRC-10693	Cannabinoid Receptor	Inflammation/Immunology
Tedalinab (GRC-10693) is a potent, orally active, and selective cannabinoid receptor 2 *(CB2)* agonist. Tedalinab has >4700-fold functional selectivity for CB2 over CB1. Tedalinab has potential for neuropathic pain and osteoarthritis treatment .

COR170	Cannabinoid Receptor	Neurological Disease Inflammation/Immunology
COR170 (11u) is a selective *CB2* inverse-agonist which is a 4-quinolone-3-carboxylic acid derivative with a K_i value of 3.8 nM for CB2 receptor. COR170 can be used for the research of inflammation and neuroprotection ^[2] .

CB-52	Cannabinoid Receptor	Inflammation/Immunology
CB-52 is the ligand and neutral antagonist of CB2 cannabinoid receptor .

LEI-101	Cannabinoid Receptor	Neurological Disease
LEI-101 is a potent, selective, and orally bioavailable *cannabinoid CB2* receptor** agonist, with a pEC₅₀ of 8 for hCB2, and a pK_i of less than 4 for hERG. LEI-101 is ~100-fold more potent in binding to CB2 receptors than to CB1 receptors ^[2].

Vicasinabin RG7774	Cannabinoid Receptor	Neurological Disease
Vicasinabin (RG7774) is the potent agonist of cannabinoid receptor 2 (CB2). Vicasinabin has the potential for the research of human diseases including chronic pain, atherosclerosis, regulation of bone mass, neuroinflammation, and other related diseases (extracted from patent US20130116236A1) .

PSB-SB-487	GPR55 Cannabinoid Receptor	Neurological Disease Metabolic Disease Cancer
PSB-SB-487 is a potent GPR55 antagonist and *CB₂* agonist with an IC₅₀ value of 0.113 µM for GPR55, and a K_i value of 0.292 µM for human CB₂. PSB-SB-487 can be used for researching diabetes, Parkinson’s disease, neuropathic pain, and cancer .

Cat. No.	Product Name	Type

HY-W127407

Glycerophospho-N-arachidonoyl ethanolamine

Biochemical Assay Reagents

Glycerophospho-N-Arachidonoyl Ethanolamine is a N-acylated ethanolamines (NAEs). Most NAEs are naturally occurring lipids with diverse biological activities. Different types of NAE can be derived from glycerophosphate-linked precursors through the activity of glycerophosphodiesterase 1 (GDE1). Glycerophosphate-N-Arachidonoyl Ethanolamine is the precursor of Anandamide (AEA), also known as Anandamide. AEA is an endocannabinoid neurotransmitter that binds to central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. It inhibits the specific binding of [3H]-HU-243 to synaptosomal membranes with a Ki value of 52 nM compared to 46 nM for δ9-THC.

Cat. No.	Product Name	Target	Research Area

HY-P1397A

RVD-Hpα TFA	Cannabinoid Receptor
RVD-Hpα TFA is the N-terminally extended form of human hemopressin that acts as a selective CB1 receptor agonist. RVD-Hpα TFA increases intracellular Ca ²⁺ levels in cells expressing CB1 receptors in vitro. RVD-Hpα TFA also high affinity CB2 positive allosteric modulator (K_i=50 nM).

Species:	Human (2)
Tag:	His (1)
Source:	HEK293 (1) E. coli Cell-free (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P700636

	CNR2 Protein-VLP, Human (HEK293) CNR2; cannabinoid receptor 2 (macrophage); cannabinoid receptor 2; CB2	Human	HEK293
	CNR2 Protein-VLP, Human (HEK293) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays.

HY-P702255

	CNR2 Protein, Human (Cell-Free, His) Cannabinoid receptor 2; CX5; CB-2; CB2	Human	E. coli Cell-free
	CNR2 Protein-VLP, a heterotrimeric G protein-coupled receptor, crucially inhibits adenylate cyclase, mediating functions in inflammatory responses, nociceptive transmission, and bone homeostasis. Its modulation of cellular signaling underscores its significance in physiological processes, positioning CNR2 Protein-VLP as a key regulator in inflammatory, sensory mechanisms, and bone equilibrium. CNR2 Protein, Human (Cell-Free, His) is the recombinant human-derived CNR2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of CNR2 Protein, Human (Cell-Free, His) is 360 a.a., with molecular weight of 42.5 kDa.

Cat. No.	Product Name		Classification

HY-155481

CB2 receptor antagonist 3		Azide
CB2 receptor antagonist 3 (compound (S)-1) is an inverse agonist of the cannabinoid receptor CB2R with Kd=39 nM. CB2 receptor antagonist 3 can be used as a tool to synthesize a variety of CB2R probes .

HY-155481A

CB2 receptor antagonist 4

Azide

CB2 receptor antagonist 4 (compound (R)-1) is a CB2R-selective inverse agonist with a K_d value of 39 nM .

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CB2

Inhibitors & Agonists

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