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Targets Recommended: CCR
Results for "

CC-292

" in MCE Product Catalog:
Cat. No. Product Name Target Research Areas
  • HY-18012
    Spebrutinib

    AVL-292; CC-292

    Btk Cancer
    Spebrutinib (AVL-292; CC-292) is a covalent, orally active, and highly selective with an IC50 of 0.5 nM.
  • HY-18012A
    Spebrutinib besylate

    AVL-292 benzenesulfonate; CC-292 besylate

    Btk Cancer
    Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a potent inhibitor of Btk kinase activity (IC50<0.5 nM, Kinact/Ki=7.69×10 4 M -1s -1s) in biochemical assays.
  • HY-100338
    CNX-500

    Btk Cancer
    CNX-500 is a probe consisting of a covalent Btk inhibitor (CC-292) chemically linked to biotin. CNX-500 retains inhibitory activity against Btk (IC50 of 0.5 nM) and the ability to form a covalent bond with Btk. CNX-500 has low inhibitory effects on kinase epidermal growth factor receptor, and upstream Src-family kinases including Syk and Lyn.