Search Result

Results for "

CCL2

" in MCE Product Catalog:

By Targets:	CCR (4) Complement System (1) DNA/RNA Synthesis (1) Histone Methyltransferase (3) Keap1-Nrf2 (1) Melanocortin Receptor (1) NF-κB (1) Parasite (3) PGE synthase (1) PPAR (1) TGF-beta/Smad (2)
By Research Areas:	Cancer (6) Endocrinology (1) Infection (4) Inflammation/Immunology (13) Metabolic Disease (2) Neurological Disease (4)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas

HY-B0673S

Pirfenidone-d5 AMR69-d₅	TGF-beta/Smad CCR	Cancer Inflammation/Immunology
Pirfenidone-d₅ is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities[1][2][3].

HY-116247

ST247	PPAR	Metabolic Disease Inflammation/Immunology
ST247 a potent PPARβ/δ inverse agonist. ST247 has a higher affinity to PPARβ/δ. ST247 modulates expression of the activation marker CCL2 in the opposite direction. ST247 efficiently induces the interaction with corepressors. ST247 inhibits the agonist-induced transcriptional activity of PPARβ/δ.

HY-P99188

Carlumab CNTO 888	CCR	Cancer
Carlumab (CNTO 888) is a humanised anti-CCL2 (chemokine ligand 2) antibody with high affinity. Carlumab can be used in cancer research, particularly in prostate cancer.

HY-148100

Emapticap pegol NOX-E36	Others	Cancer Inflammation/Immunology
Emapticap pegol is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36).

HY-B0673

Pirfenidone AMR69	TGF-beta/Smad CCR	Inflammation/Immunology Cancer
Pirfenidone (AMR69) is an antifibrotic agent that attenuates *CCL2* and *CCL12* production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces *TGF-β2* protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities.

HY-W104821

Rosolic Acid	Keap1-Nrf2	Metabolic Disease
Rosolic Acid is an activator of *Nrf2, as well as its downstream targets. Rosolic Acid increases the levels of angiogenic factors, decreases inflammation (TNF-α* and IL-1β) and apoptotic markers (CXCL10 and *CCL2*). Rosolic Acid restores the function of pancreatic cells and protects endothelial cells (ECs) from endoplasmic reticulum stressed.

HY-B0498

Bindarit AF2838	CCR	Inflammation/Immunology Neurological Disease Cancer Endocrinology
Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins *MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL*23. Bindarit also has anti-inflammatory activity.

HY-149202

UT-11	PGE synthase	Inflammation/Immunology
UT-11 is a potent and brain-permeable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with IC₅₀s of 0.10 μM and 2.00 μM for inhibiting PGE₂ production in human (SK-N-AS) and murine (BV2) cells, respectively.

HY-B1322

Amodiaquine dihydrochloride dihydrate Amodiaquin dihydrochloride dihydrate	Parasite Histone Methyltransferase	Infection Inflammation/Immunology Neurological Disease
Amodiaquine dihydrochloride dihydrate (Amodiaquin dihydrochloride dihydrate), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine dihydrochloride dihydrate is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC₅₀ of ~20 μM. Anti-inflammatory effect.

HY-B1322A

Amodiaquine Amodiaquin	Parasite Histone Methyltransferase	Infection Inflammation/Immunology Neurological Disease
Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC₅₀ of ~20 μM. Anti-inflammatory effect.

HY-B1322B

Amodiaquine dihydrochloride Amodiaquin dihydrochloride	Parasite Histone Methyltransferase	Infection Inflammation/Immunology Neurological Disease
Amodiaquine dihydrochloride (Amodiaquin dihydrochloride), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor with a K_i of 18.6 nM. Amodiaquine dihydrochloride is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC₅₀ of ~20 μM. Anti-inflammatory effect.

HY-P99450

Avdoralimab IPH 5401; Anti-C5aR1 mAb	Complement System	Cancer Inflammation/Immunology
Avdoralimab (IPH 5401) is a fully human IgGκ monoclonal antibody that targets the complement C5a receptor 1 (C5aR1) that prevents its binding to C5a. Avdoralimab can be used for complement-driven inflammatory diseases and solid tumours research.

HY-115644

BMS-470539 dihydrochloride	Melanocortin Receptor	Inflammation/Immunology
BMS-470539 dihydrochloride is a highly potent and selective melanocortin-1 receptor (MC-1R) agonist with an IC₅₀ of 120 nM, an EC₅₀ of 28 nM. BMS-470539 dihydrochloride does not activate MC-3R and is a very weak partial agonist at MC-4R and MC-5R. BMS-470539 dihydrochloride has potently anti-inflammatory properties.

HY-120501

B022	NF-κB	Inflammation/Immunology
B022 is a potent and selective NF-κB-inducing kinase (NIK) inhibitor (K_i of 4.2 nM; IC₅₀=15.1 nM). B022 protects liver from toxin-induced inflammation, oxidative stress, and injury.

HY-120897

NS-3-008 hydrochloride	Others	Inflammation/Immunology
NS-3-008 hydrochloride is an orally active transcriptional inhibitor of G0/G1 switch 2 (G0s2) with an IC₅₀ of 2.25 μM. NS-3-008 hydrochloride can be used for chronic kidney disease.

HY-144334

CHIKV-IN-3	DNA/RNA Synthesis	Infection
CHIKV-IN-3 is a potent against two low-passage CHIKV inhibitor with EC₅₀ values of 1.55 and 0.14 µM for CHIKV-122508 and CHIKV-6708, respectively. CHIKV-IN-3 acts on the host cells to interfere with the viral replication. CHIKV-IN-3 displays minimal cytotoxic liability(CC₅₀ > 100 µM). Prophylactic effect.

Cat. No.	Product Name	Type

HY-W104821

Rosolic Acid	Biochemical Assay Reagents
Rosolic Acid is an activator of *Nrf2, as well as its downstream targets. Rosolic Acid increases the levels of angiogenic factors, decreases inflammation (TNF-α* and IL-1β) and apoptotic markers (CXCL10 and *CCL2*). Rosolic Acid restores the function of pancreatic cells and protects endothelial cells (ECs) from endoplasmic reticulum stressed.

Cat. No.	Product Name	Target	Research Area

HY-144334

CHIKV-IN-3	DNA/RNA Synthesis	Infection
CHIKV-IN-3 is a potent against two low-passage CHIKV inhibitor with EC₅₀ values of 1.55 and 0.14 µM for CHIKV-122508 and CHIKV-6708, respectively. CHIKV-IN-3 acts on the host cells to interfere with the viral replication. CHIKV-IN-3 displays minimal cytotoxic liability(CC₅₀ > 100 µM). Prophylactic effect.

Cat. No.	Product Name	Target	Research Area

HY-P99188

Carlumab CNTO 888	CCR	Cancer
Carlumab (CNTO 888) is a humanised anti-CCL2 (chemokine ligand 2) antibody with high affinity. Carlumab can be used in cancer research, particularly in prostate cancer.

HY-P99450

Avdoralimab IPH 5401; Anti-C5aR1 mAb	Complement System	Cancer Inflammation/Immunology
Avdoralimab (IPH 5401) is a fully human IgGκ monoclonal antibody that targets the complement C5a receptor 1 (C5aR1) that prevents its binding to C5a. Avdoralimab can be used for complement-driven inflammatory diseases and solid tumours research.

Cat. No.	Product Name	Target	Category

HY-B0498

Bindarit AF2838	CCR	Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Cancer Endocrinology Neurological Disease Source classification Plants Umbelliferae Angelica sinensis (Oliv.) Diels
Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins *MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL*23. Bindarit also has anti-inflammatory activity.

Species:	Human (4) Mouse (6) Rat (1) Cynomolgus (1) Pig (1)
Tag:	His (10) Tag Free (3) Avi (2)
Source:	HEK293 (6) Sf9 insect cells (2) E. coli (5)

Cat. No.	Product Name	Species	Source

HY-P78173

*MCP-1/CCL2* Protein, Human (Biotinylated, HEK293, His-Avi)** C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Human	HEK293
MCP-1/CCL2 Protein, Human (Biotinylated, HEK293, His-Avi) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein MCP-1/CCL2 Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant human MCP-1/CCL2 (Q24-T99) expressed by HEK293 with His and Avi tags at the C-terminus.

HY-P78488

*MCP-1/CCL2* Protein, Human (HEK293, His-Avi)** C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Human	HEK293
MCP-1/CCL2 Protein, Human (HEK293, His-Avi) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein MCP-1/CCL2 Protein, Human (HEK293, His-Avi) is a recombinant human MCP-1/CCL2 (Q24-T99) expressed by HEK293 with His and Avi tags at the C-terminus.

HY-P700787

MCP-1/CCL2 Protein, Cynomolgus (HEK293, His)
C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2
Cynomolgus HEK293
HY-P700034AF

Animal-Free MCP-1/CCL2 Protein, Human (His)
C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2
Human E. coli

HY-P7764

*MCP-1/CCL2* Protein, Mouse** rMuCCL2; C-C motif chemokine 2; Monocyte chemoattractant protein 1; Monocyte chemotactic protein 1; MCP-1; CCL2; Scya2	Mouse	E. coli
MCP-1/CCL2 Protein, Mouse is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse is a mouse MCP-1/CCL2 (Q24-R96) expressed by E.coil.

HY-P700231AF

Animal-Free CCL2 Protein, Pig (His)
C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2
Pig E. coli

HY-P7237

*MCP-1/CCL2* Protein, Human** rHuMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Human	E. coli
MCP-1/CCL2 Protein, Human is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein MCP-1/CCL2 Protein, Human is a recombinant human MCP-1/CCL2(Q24-T99) expressed by E.coil.

HY-P7235

*MCP-1/CCL2* Protein, Mouse (HEK293)** rMuMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Mouse	HEK293
MCP-1/CCL2 Protein, Mouse (HEK293) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (HEK293) is a mouse MCP-1/CCL2 (Q24-R96) expressed by HEK293.

HY-P7236

*MCP-1/CCL2* Protein, Rat (HEK293, C-His)** rRtMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Rat	HEK293
MCP-1/CCL2 Protein, Rat (HEK293, His) is a small cytokine that belongs to the CC chemokine family.

HY-P72757

*MCP-1/CCL2* Protein, Mouse (HEK293, His)** C-C motif chemokine ligand 2; GDCF-2; HC11; HSMCR30; MCAF; SCYA2; SMC-CF	Mouse	HEK293
MCP-1/CCL2 Protein, Mouse (HEK293, His) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (HEK293, His) is a mouse MCP-1/CCL2 (Q24-N148) expressed by HEK293 with a His tag at the C-terminus.

HY-P74758

*MCP-1/CCL2* Protein, Mouse (sf9, His)** C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Mouse	Sf9 insect cells
MCP-1/CCL2 Protein, Mouse (sf9, His) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (sf9, His) is a mouse MCP-1/CCL2 (M1-N148) expressed by Spodoptera frugiferda(Sf9) with a His tag at the C-terminus.

HY-P76489

*MCP-1/CCL2* Protein, Mouse (Biotinylated, sf9, His)** C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Mouse	Sf9 insect cells
MCP-1/CCL2 Protein, Mouse (Biotinylated, sf9, His) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (Biotinylated, sf9, His) is a biotinylated mouse MCP-1/CCL2 (M1-N148) expressed by Spodoptera frugiferda(Sf9) with a His tag at the C-terminus.

HY-P700164AF

Animal-Free MCP-1/CCL2 Protein, Mouse (His)
Monocyte Chemotactic Protein-1; MCP-1; JE
Mouse E. coli

Cat. No.	Product Name

HY-B0673S

Pirfenidone-d5
Pirfenidone-d₅ is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities[1][2][3].

CCL2

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Natural
Products