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Results for "

CCRF-CEM

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adrenergic Receptor (1) Antibiotic (1) Apoptosis (8) Autophagy (1) Bcl-2 Family (2) Caspase (3) CDK (1) Deubiquitinase (1) DNA Methyltransferase (1) DNA/RNA Synthesis (2) Dopamine Receptor (1) Drug Metabolite (2) E3 Ligase Ligand-Linker Conjugates (1) HBV (1) HDAC (1) Histone Demethylase (3) MDM-2/p53 (1) Necroptosis (1) Nucleoside Antimetabolite/Analog (2) P-glycoprotein (2) PARP (2) PROTACs (1) Topoisomerase (2)
By Research Areas:	Cancer (29) Infection (2) Neurological Disease (1)

By Targets:

5-HT Receptor (1)

Adrenergic Receptor (1)

Antibiotic (1)

Apoptosis (8)

Autophagy (1)

Bcl-2 Family (2)

Caspase (3)

CDK (1)

Deubiquitinase (1)

DNA Methyltransferase (1)

DNA/RNA Synthesis (2)

Dopamine Receptor (1)

Drug Metabolite (2)

E3 Ligase Ligand-Linker Conjugates (1)

HBV (1)

HDAC (1)

Histone Demethylase (3)

MDM-2/p53 (1)

Necroptosis (1)

Nucleoside Antimetabolite/Analog (2)

P-glycoprotein (2)

PARP (2)

PROTACs (1)

Topoisomerase (2)

By Research Areas:

Cancer (29)

Infection (2)

Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N8386

Berkeleylactone F

Antibiotic Infection Cancer

Berkeleylactone F is an antibiotic macrolide compound. Berkeleylactone F showed modest inhibition of CCRF-CEM leukemia cells .

Berkeleylactone F	Antibiotic	Infection Cancer
Berkeleylactone F is an antibiotic macrolide compound. Berkeleylactone F showed modest inhibition of CCRF-CEM leukemia cells .

HY-N8272

Neocyclomorusin	Others	Cancer
Neocyclomorusin (compound 6) is a flavonoid. Neocyclomorusin can be isolated from Erythrina sigmoidea. Neocyclomorusin inhibits the CCRF-CEM cell line with an IC50 value of 59.02 μM .

HY-N1665

2',4'-Dihydroxy-3',6'-dimethoxychalcone	Others	Cancer
2',4'-Dihydroxy-3',6'-dimethoxychalcone is a natural product that can be isolated from Polygonum Lapathifolium. 2',4'-Dihydroxy-3',6'-dimethoxychalcone inhibits the growth of CCRF-CEM leukaemia cells and CEM/ADR5000 cells, with IC₅₀ values of 10.67 and 18.60 μM, respectively .

HY-157464

[Ru(phen)2(4-Me-Sal)]BF4	Others	Cancer
[Ru(phen)2(4-Me-Sal)]BF4 (compound 10), a Ru(II)-based polypyridyl complexe, displays outstanding antiproliferative activity against drug-sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 leukemia cells (IC₅₀=0.52 μM and 5.56 μM, respectively) .

HY-163435

Anticancer agent 201	Apoptosis Caspase PARP Bcl-2 Family	Cancer
Anticancer agent 201 (Compound 2f) has IC₅₀ values in the low micromolar range for multiple tumor cell lines. Anticancer agent 201 is highly cytotoxic to CCRF-CEM cells in vitro, inducing apotosis by activating caspase-3 in the intrinsic mitochondrial pathway and lysis of PARP, as well as reducing the expression of Bcl-2 and Bcl-XL proteins. Anticancer agent 201 can be used in cancer research .

HY-160055

GMT 4 aptamer sodium	Others	Cancer
GMT 4 aptamer sodium is a nucleic acid aptamer targeting different glioblastoma cell lines and exhibits high affinity. GMT 4 aptamer sodium also shows high binding affinity to the T lymphocyte cell line CCRF-CEM .

HY-160057

GMT 8 aptamer sodium	Others	Cancer
GMT 8 aptamer sodium is a nucleic acid aptamer targeting different glioblastoma cell lines and exhibits high affinity. GMT 4 aptamer sodium also shows high binding affinity to the T lymphocyte cell line CCRF-CEM .

HY-147514

Anticancer agent 64	Apoptosis Caspase PARP Bcl-2 Family	Cancer
Anticancer agent 64 (compound 5m) shows cytotoxic activity in CCRF-CEM cells, with IC₅₀ of 2.4 μM. Anticancer agent 64 shows good anticancer activity through apoptosis induction. Anticancer agent 64 induces caspase 3 and 7 activation and PARP cleavage. Anticancer agent 64 induces significant effect of mitochondria depolarization .

HY-100777

DACA
DACA inhibits two essential nuclear enzymes in vitro, DNA topoisomerase I and DNA topoisomerase (topo) II. DACA stabilises topo I, topo II alpha, and topo II beta cleavable complexes in human leukaemia CCRF-CEM cells .

HY-156775

Antitumor agent-119	Others	Cancer
Antitumor agent-119 (compound 13K) is a 2-benzoxazolyl hydrazone derivative with anticancer activities. Antitumor agent-119 inhibits the cell growth of Butkitt, CCRF-CEM, HeLa, and HT-29 with IC₅₀ values of 30 nM, 140 nM, 100 nM, and 40 nM, respectively .

HY-146316

Topoisomerase II inhibitor 6	Topoisomerase	Cancer
Topoisomerase II inhibitor 6 (Compound 5), a tryptanthrin derivative, is a potent and selective inhibitor of topoisomerase II. Topoisomerase II inhibitor 6 exhibits antiproliferative activity on different tumor cell lines. Topoisomerase II inhibitor 6 blocks the cell cycle of CCRF-CEM in the G2 phase and induces DNA DSB. Topoisomerase II inhibitor 6 has the potential for the research of cancer diseases .

HY-147901

KDM1/CDK1-IN-1	Histone Demethylase CDK Apoptosis Caspase	Cancer
KDM1/CDK1-IN-1 (compound 4) is a potent KDM1 and CDK1 inhibitor, with IC₅₀ values of 0.096 and 0.078 μM, respectively.KDM1/CDK1-IN-1 induces cell cycle arrest at G2/M phase and apoptosis in HOP-92 cells. KDM1/CDK1-IN-1 exhibits potent cytotoxic activity against the CCRF-CEM, HOP-92 and Hep-G2 cells, with IC₅₀ values of 16.34, 3.45 and 7.79 μM, respectively .

HY-N1365

Isoscopoletin 6-Hydroxy-7-methoxycoumarin	HBV	Infection Cancer
Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves. Isoscopoletin shows substantial inhibition against cell proliferation, with IC₅₀s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug resistant subline CEM/ADR5000, respectively . Isoscopoletin (6-Hydroxy-7-methoxycoumarin) possesses inhibitory activity against HBV replication .

HY-151190

cis-4-Br-2,5-F2-PCPA S1024	Histone Demethylase	Cancer
cis-4-Br-2,5-F2-PCPA (S1024) is a selective inhibitor of lysine-specific demethylase 1 (LSD1), with a K_i value of 94 nM instead of 8.4 μM for LSD2. There is aberrant expression of LSD1 in cancer stem cells, cis-4-Br-2,5-F2-PCPA inhibits LSD1 cell proliferation and by increasing the level of dimethylated histone H3 at K4 (H3K4) in CCRF-CEM cells .

HY-162377

HDAC-IN-70	HDAC Apoptosis Necroptosis	Cancer
HDAC-IN-70 (compound 4c) is HDAC6 inhibitor with the IC₅₀ values of 64.13 nM, 166 nM, 618 nM and 253 nM for HDAC6, HDAC1, HDAC2 and HDAC4, respectively. HDAC-IN-70 induces cell cycle arrest, apoptosis and necrotic. HDAC-IN-70 can be used for study of leukemia .

HY-133219

Guajadial C

Topoisomerase Cancer

Guajadial C is a Top1 catalytic inhibitor that delays Top1 poison-mediated DNA damage. Guajadial C shows cytotoxicity against cancer cells .

Guajadial C	Topoisomerase	Cancer
Guajadial C is a Top1 catalytic inhibitor that delays Top1 poison-mediated DNA damage. Guajadial C shows cytotoxicity against cancer cells .

HY-151191

LSD1-IN-22	Histone Demethylase	Cancer
LSD1-IN-22 is a potent Lysine-specific demethylase 1 (LSD1) inhibitor with a K_i value of 98 nM. LSD1-IN-22 has anti-proliferative activity against certain cancer cells .

HY-149222

Apoptosis inducer 12	Apoptosis	Cancer
Apoptosis inducer 12 (Compound 3z) is an apoptosis inducer that induces apoptosis through the mitochondrial pathway. Apoptosis inducer 12 can be used for the research of cancer .

HY-133141

DI-87	Others	Cancer
DI-87 is an orally active and selective deoxycytidine kinase (dCK) inhibitor with an EC₅₀ of 10.2 nM. DI-87 has antitumor activity and is used in combination therapy against tumors expressing dCK .

HY-W773183

Methyl betulonate Betulonic acid methyl ester; Methyl 3-oxolup-20(29)-en-28-oate	Others	Cancer
Methyl betulonate (Betulonic acid methyl ester) is a triterpenoid. Methyl betulonate inhibits cell growth of eight tumor (including resistant) and two normal fibroblast cell lines with the IC_50s >50.0 μM .

HY-139015

5-Aza-4'-thio-2'-deoxycytidine 5-Aza-T-dCyd; NTX-301	DNA Methyltransferase	Cancer
5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd) is an orally active DNA methyltransferase I (DNMT1) inhibitor. 5-Aza-4'-thio-2'-deoxycytidine, a sulfur-containing deoxy-cytidine analog, has the potential for DNA hypomethylating and has antitumor effects .

HY-136499

DI-82

Others Cancer

DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC₅₀ ^app of 27.8 nM and K_i ^app of 9.2 nM. DI-82 has antitumor activity .

DI-82	Others	Cancer
DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC₅₀ ^app of 27.8 nM and K_i ^app of 9.2 nM. DI-82 has antitumor activity .

HY-130854

Thalidomide-NH-C6-NH-Boc	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-NH-C6-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used for MI-389 (compound 22) synthesis. MI-389 is a potent phthalimide PROTAC degrader based on the multi-targeted receptor tyrosine kinase inhibitor sunitinib (HY-10255A) .

HY-N7205

Glaucocalyxin D	Others	Cancer
Glaucocalyxin D is a ent-kauranoid-type diterpenoid that can be isolated from Rabdosia japonica. Glaucocalyxin D shows cytotoxicity against various human tumor cell lines. Glaucocalyxin D can be used for cancer research .

HY-136650

Fludarabine triphosphate F-ara-ATP	Nucleoside Antimetabolite/Analog Drug Metabolite DNA/RNA Synthesis Apoptosis	Cancer
Fludarabine triphosphate (F-ara-ATP), the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC₅₀ of 2.3 μM and a K_i of 6.1 μM. Fludarabine triphosphate inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis .

HY-136650A

Fludarabine triphosphate trisodium F-ara-ATP trisodium	Nucleoside Antimetabolite/Analog Drug Metabolite DNA/RNA Synthesis Apoptosis	Cancer
Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC₅₀ of 2.3 μM and a K_i of 6.1 μM. Fludarabine triphosphate trisodium inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis .

HY-50671

Zosuquidar trihydrochloride Maximum Cited Publications 14 Publications Verification RS 33295-198 trihydrochloride; LY-335979 trihydrochloride	P-glycoprotein	Cancer
Zosuquidar (LY335979) trihydrochloride is a P-glycoprotein (P-gp) inhibitor (K_i=59 nM). Zosuquidar trihydrochloride shows anti-tumor activities, and can be used in acute myelogenous leukemia (AML) research .

HY-15255

Zosuquidar Maximum Cited Publications 14 Publications Verification RS 33295-198; LY-335979	P-glycoprotein	Cancer
Zosuquidar (LY335979) is a P-glycoprotein (P-gp) inhibitor (K_i=59 nM). Zosuquidar shows anti-tumor activities, and can be used in acute myelogenous leukemia (AML) research .

HY-148369

U7D-1	PROTACs Deubiquitinase Apoptosis MDM-2/p53	Cancer
U7D-1 is a first-in-class potent and selective USP7 (ubiquitin-specific protease 7) PROTAC degrader, with a DC₅₀ of 33 nM in RS4;11 cells. U7D-1 shows anticancer activity. U7D-1 induces apoptosis in Jeko-1 cells .

HY-14543

Sertindole 2 Publications Verification Lu 23-174	5-HT Receptor Dopamine Receptor Adrenergic Receptor Autophagy	Neurological Disease Cancer
Sertindole (Lu 23-174) is an orally active 5-HT_2A, 5-HT_2C, dopamine D₂, and αl-adrenergic receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple cancer cells .

Isoscopoletin 6-Hydroxy-7-methoxycoumarin	Structural Classification Classification of Application Fields Source classification Coumarins Plants Compositae Infection Monophenols other families Phenols Phenylpropanoids Disease Research Fields Sindora sumatrana Miq. Cancer	HBV
Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves. Isoscopoletin shows substantial inhibition against cell proliferation, with IC₅₀s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug resistant subline CEM/ADR5000, respectively . Isoscopoletin (6-Hydroxy-7-methoxycoumarin) possesses inhibitory activity against HBV replication .

Berkeleylactone F	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Antibiotic
Berkeleylactone F is an antibiotic macrolide compound. Berkeleylactone F showed modest inhibition of CCRF-CEM leukemia cells .

Neocyclomorusin	Structural Classification Flavonoids Leguminosae Source classification Plants Other Flavonoids Erythrina sigmoidea Hua	Others
Neocyclomorusin (compound 6) is a flavonoid. Neocyclomorusin can be isolated from Erythrina sigmoidea. Neocyclomorusin inhibits the CCRF-CEM cell line with an IC50 value of 59.02 μM .

2',4'-Dihydroxy-3',6'-dimethoxychalcone	Flavonoids Chalcones Classification of Application Fields Polygonaceae Source classification Phenols Polyphenols Plants Disease Research Fields Perilla ocimoides L. Cancer	Others
2',4'-Dihydroxy-3',6'-dimethoxychalcone is a natural product that can be isolated from Polygonum Lapathifolium. 2',4'-Dihydroxy-3',6'-dimethoxychalcone inhibits the growth of CCRF-CEM leukaemia cells and CEM/ADR5000 cells, with IC₅₀ values of 10.67 and 18.60 μM, respectively .

Guajadial C	Structural Classification Terpenoids Source classification Psidium guajava Linn. Myrtaceae Plants	Topoisomerase
Guajadial C is a Top1 catalytic inhibitor that delays Top1 poison-mediated DNA damage. Guajadial C shows cytotoxicity against cancer cells .

Glaucocalyxin D	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Solidago virgaurea L.	Others
Glaucocalyxin D is a ent-kauranoid-type diterpenoid that can be isolated from Rabdosia japonica. Glaucocalyxin D shows cytotoxicity against various human tumor cell lines. Glaucocalyxin D can be used for cancer research .

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Inhibitors & Agonists

NaturalProducts

Natural
Products