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CD-161

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Epigenetic Reader Domain (2)
By Research Areas:	Cancer (2)

2

Inhibitors & Agonists

6

Recombinant Proteins

1

Antibodies

Targets Recommended: CD38 CD28 CD19 CD20 CD22 CD3 CD6 CD2 CD73 ALCAM/CD166 CD74 CD276/B7-H3 P-selectin Transferrin Receptor c-Kit LAG-3 CTLA-4 Neprilysin Tim3 FLT3 Anaplastic lymphoma kinase (ALK) P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

*CD161* NKR-P1A	Epigenetic Reader Domain	Cancer
CD161 (NKR-P1A) is a potent, selective and orally bioavailable bromodomain and extra-terminal (BET) bromodomain inhibitor with an IC₅₀s of 28.2 nM and 7.2 nM for BRD4 BD1 and BRD4 BD2, respectively. CD161 has good anticancer activity .

HY-128977

CD235

Epigenetic Reader Domain Cancer

CD235 is a structurally similar analogue of CD161. CD161 is a potent and orally bioavailable BET bromodomain inhibitor .

Species:	Human (2) Mouse (2) Cynomolgus (2)
Tag:	His (4) Avi (3) Fc (2)
Source:	HEK293 (6)

Cat. No.	Compare	Product Name	Species	Source

	CD161 Protein, Human (HEK293, Fc) Killer cell lectin-like receptor subfamily B member 1; NKR-P1A; CD161; KLRB1; CLEC5B	Human	HEK293
	CD161 protein plays a crucial role in inhibiting NK cell toxicity by activating specific acid sphingomyelinase/SMPD1 and increasing ceramide levels. Activation stimulates AKT1/PKB and RPS6KA1/RSK1 kinases, enhancing anti-CD3-induced T cell proliferation. CD161 Protein, Human (HEK293, Fc) is the recombinant human-derived CD161 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD161 Protein, Human (HEK293, Fc) is 159 a.a., with molecular weight of 55-70 kDa.

	CD161 Protein, Human (Biotinylated, HEK293, His-Avi) KLRB1; CLEC5B; NKRP1A; NKR-P1A; HNKR-P1a; CD161; Ly59; NKR; NKRP1; NKR-P1; NKRP1ANKR	Human	HEK293
	CD161 protein plays a crucial role in inhibiting NK cell toxicity by activating specific acid sphingomyelinase/SMPD1 and increasing ceramide levels. Activation stimulates AKT1/PKB and RPS6KA1/RSK1 kinases, enhancing anti-CD3-induced T cell proliferation. CD161 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD161 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of CD161 Protein, Human (Biotinylated, HEK293, His-Avi) is 159 a.a., with molecular weight of 35-43 kDa.

	CD161 Protein, Cynomolgus (HEK293, His) KLRB1; CLEC5B; NKRP1A; NKR-P1A; HNKR-P1a; CD161; Ly59; NKR; NKRP1; NKR-P1; NKRP1ANKR	Cynomolgus	HEK293
	CD161 Protein plays a crucial role in inhibiting NK cell cytotoxicity by activating specific acid sphingomyelinase/SMPD1, elevating ceramide levels. Activation stimulates AKT1/PKB and RPS6KA1/RSK1 kinases, enhancing anti-CD3-induced T-cell proliferation. As a lectin, CD161 binds to Gal-alpha(1,3)Gal and N-acetyllactosamine epitopes, acting as a ligand for CLEC2D/LLT1. Existing as a homodimer, CD161 interacts with acid sphingomyelinase/SMPD1, contributing to its multifaceted immune regulatory functions. CD161 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD161 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD161 Protein, Cynomolgus (HEK293, His) is 161 a.a., with molecular weight of 38-48 kDa.

	CD161 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) KLRB1; CLEC5B; NKRP1A; NKR-P1A; HNKR-P1a; CD161; Ly59; NKR; NKRP1; NKR-P1; NKRP1ANKR	Cynomolgus	HEK293
	CD161 Protein plays a crucial role in inhibiting NK cell cytotoxicity by activating specific acid sphingomyelinase/SMPD1, elevating ceramide levels. Activation stimulates AKT1/PKB and RPS6KA1/RSK1 kinases, enhancing anti-CD3-induced T-cell proliferation. As a lectin, CD161 binds to Gal-alpha(1,3)Gal and N-acetyllactosamine epitopes, acting as a ligand for CLEC2D/LLT1. Existing as a homodimer, CD161 interacts with acid sphingomyelinase/SMPD1, contributing to its multifaceted immune regulatory functions. CD161 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) is the recombinant cynomolgus-derived CD161 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of CD161 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) is 161 a.a., with molecular weight of 37-42 kDa.

	*KLRB1F/CD161f Protein, Mouse (HEK293, Fc)* Killer cell lectin-like receptor subfamily B member 1F; CD161f; Nkrp1f	Mouse	HEK293
	The KLRB1F/CD161f protein is thought to bind CLEC2I/Clr-g, activate natural killer cells and provide costimulation for IL-2 production and T cell proliferation. This dual function highlights its critical role in coordinating immune responses. KLRB1F/CD161f Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived KLRB1F/CD161f protein, expressed by HEK293 , with N-hFc labeled tag. The total length of KLRB1F/CD161f Protein, Mouse (HEK293, Fc) is 151 a.a., with molecular weight of 50-55 kDa.

	Klrb1a Protein, Mouse (HEK293, His) Killer cell lectin-like receptor subfamily B member 1A; NKR-P1A; Ly-55A; CD161a	Mouse	HEK293
	The Klrb1a protein is critical for stimulating NK cell cytotoxicity and contributes to immune defense mechanisms. Klrb1a exists as a homodimer with disulfide bonds and complexly regulates NK cell activity. Klrb1a Protein, Mouse (HEK293, His) is the recombinant mouse-derived Klrb1a protein, expressed by HEK293 , with N-His labeled tag. The total length of Klrb1a Protein, Mouse (HEK293, His) is 161 a.a., with molecular weight of 30-35 kDa.

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