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Results for "

CEM

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Antibiotic (2) Apoptosis (6) Autophagy (1) Bacterial (2) Bcl-2 Family (2) Caspase (3) CCR (1) CDK (1) CRISPR/Cas9 (1) DNA/RNA Synthesis (1) Endogenous Metabolite (1) Epigenetic Reader Domain (1) FAK (1) Farnesyl Transferase (1) GLUT (1) HBV (1) Histone Demethylase (2) HIV (3) HIV Protease (1) Na+/K+ ATPase (1) Parasite (1) PARP (2) Renin (1) Topoisomerase (1)
By Research Areas:	Cancer (22) Cardiovascular Disease (1) Infection (9) Inflammation/Immunology (2)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17593

Solithromycin 2 Publications Verification CEM-101; OP-1068	Bacterial Antibiotic	Infection
Solithromycin (CEM-101) is an orally bioavailable, effective antimicrobial agent, with IC₅₀s for inhibition of cell viability, protein synthesis, and growth rate are 7.5 ng/mL, 40 ng/mL, and 125 ng/mL for Streptococcus pneumonia, Staphylococcus aureus, and Haemophilus influenzae, respectively. Solithromycin binds to the large 50S subunit of the ribosome and inhibits protein biosynthesis .

HY-147385

CCR4 antagonist 3	CCR	Inflammation/Immunology
CCR4 antagonist 3 is a potent chemokine receptor 4 (CCR4) antagonist with an IC₅₀ value of 1.7 μM for [ ¹²⁵I]TARC (thymus and activation regulated chemokine). CCR4 antagonist 3 inhibits binding of radiolabeled TARC and macrophage-derived chemokine (MDC) to CCR4 receptors on the surface of CEM cells. CCR4 antagonist 3 also inhibits the in vitro migration of CEM cells mediated by TARC (IC50 = 6.4 μM) .

HY-136572

CEM114	Epigenetic Reader Domain CRISPR/Cas9	Cancer
CEM114 is an effective chemical epigenetic modifier (CEM) that recruits endogenous chromatin machinery through CRISPR-Cas9 systems .

HY-N8386

Berkeleylactone F

Antibiotic Infection Cancer

Berkeleylactone F is an antibiotic macrolide compound. Berkeleylactone F showed modest inhibition of CCRF-CEM leukemia cells .

Berkeleylactone F	Antibiotic	Infection Cancer
Berkeleylactone F is an antibiotic macrolide compound. Berkeleylactone F showed modest inhibition of CCRF-CEM leukemia cells .

HY-N1665

2',4'-Dihydroxy-3',6'-dimethoxychalcone	Others	Cancer
2',4'-Dihydroxy-3',6'-dimethoxychalcone is a natural product that can be isolated from Polygonum Lapathifolium. 2',4'-Dihydroxy-3',6'-dimethoxychalcone inhibits the growth of CCRF-CEM leukaemia cells and CEM/ADR5000 cells, with IC₅₀ values of 10.67 and 18.60 μM, respectively .

HY-157464

[Ru(phen)2(4-Me-Sal)]BF4	Others	Cancer
[Ru(phen)2(4-Me-Sal)]BF4 (compound 10), a Ru(II)-based polypyridyl complexe, displays outstanding antiproliferative activity against drug-sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 leukemia cells (IC₅₀=0.52 μM and 5.56 μM, respectively) .

HY-123415

PD 134922

HIV Protease Renin Infection

PD 134922 is a potent renin and HIV-1 protease inhibitor with an IC₅₀ of 15 nM against HIV-1 protease .

PD 134922	HIV Protease Renin	Infection
PD 134922 is a potent renin and HIV-1 protease inhibitor with an IC₅₀ of 15 nM against HIV-1 protease .

HY-N1365

Isoscopoletin 6-Hydroxy-7-methoxycoumarin	HBV	Infection Cancer
Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves. Isoscopoletin shows substantial inhibition against cell proliferation, with IC₅₀s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug resistant subline CEM/ADR5000, respectively . Isoscopoletin (6-Hydroxy-7-methoxycoumarin) possesses inhibitory activity against HBV replication .

HY-N8272

Neocyclomorusin	Others	Cancer
Neocyclomorusin (compound 6) is a flavonoid. Neocyclomorusin can be isolated from Erythrina sigmoidea. Neocyclomorusin inhibits the CCRF-CEM cell line with an IC50 value of 59.02 μM .

HY-160055

GMT 4 aptamer sodium	Others	Cancer
GMT 4 aptamer sodium is a nucleic acid aptamer targeting different glioblastoma cell lines and exhibits high affinity. GMT 4 aptamer sodium also shows high binding affinity to the T lymphocyte cell line CCRF-CEM .

HY-160057

GMT 8 aptamer sodium	Others	Cancer
GMT 8 aptamer sodium is a nucleic acid aptamer targeting different glioblastoma cell lines and exhibits high affinity. GMT 4 aptamer sodium also shows high binding affinity to the T lymphocyte cell line CCRF-CEM .

HY-P5738

Palicourein	Bacterial	Infection
Palicourein is a 37 amino acid cyclic polypeptide. Palicourein inhibits the in vitro cytopathic effects of HIV-1RF infection of CEM-SS cells with an EC₅₀ value of 0.1 μM and an IC₅₀ value of 1.5 μM .

HY-100777

DACA
DACA inhibits two essential nuclear enzymes in vitro, DNA topoisomerase I and DNA topoisomerase (topo) II. DACA stabilises topo I, topo II alpha, and topo II beta cleavable complexes in human leukaemia CCRF-CEM cells .

HY-156775

Antitumor agent-119	Others	Cancer
Antitumor agent-119 (compound 13K) is a 2-benzoxazolyl hydrazone derivative with anticancer activities. Antitumor agent-119 inhibits the cell growth of Butkitt, CCRF-CEM, HeLa, and HT-29 with IC₅₀ values of 30 nM, 140 nM, 100 nM, and 40 nM, respectively .

HY-N11690

Oleandrigenin

Na+/K+ ATPase Cardiovascular Disease Cancer

Oleandrigenin is a potent cardiotonic steroid. Oleandrigenin shows Na ⁺/K ⁺-ATP-ase inhibiting and cytotoxic activities .

Oleandrigenin	Na+/K+ ATPase	Cardiovascular Disease Cancer
Oleandrigenin is a potent cardiotonic steroid. Oleandrigenin shows Na ⁺/K ⁺-ATP-ase inhibiting and cytotoxic activities .

HY-W008469

2-Fluoroadenine	DNA/RNA Synthesis	Cancer
2-Fluoroadenine is a toxic purine bases. 2-Fluoroadenine has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for researching anticancer .

HY-147520

FAK-IN-5

FAK Apoptosis Autophagy Cancer

FAK-IN-5 (Compound 8l) is a FAK signaling inhibitor. FAK-IN-5 induces cell apoptosis and autophagy .

FAK-IN-5	FAK Apoptosis Autophagy	Cancer
FAK-IN-5 (Compound 8l) is a FAK signaling inhibitor. FAK-IN-5 induces cell apoptosis and autophagy .

HY-163177

HIV-1 inhibitor-63	HIV	Infection
HIV-1 inhibitor-63 (compound S17) is a potent HIV-1 inhibitor. HIV-1 inhibitor-63 inhibits integrase-Ku70 complex formation with an IC₅₀ value of 12 µM. HIV-1 inhibitor-63 inhibits HIV-1 post-integration DNA repair .

HY-147514

Anticancer agent 64	Apoptosis Caspase PARP Bcl-2 Family	Cancer
Anticancer agent 64 (compound 5m) shows cytotoxic activity in CCRF-CEM cells, with IC₅₀ of 2.4 μM. Anticancer agent 64 shows good anticancer activity through apoptosis induction. Anticancer agent 64 induces caspase 3 and 7 activation and PARP cleavage. Anticancer agent 64 induces significant effect of mitochondria depolarization .

HY-N7634

Tectol	Farnesyl Transferase Parasite	Infection Cancer
Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM . Tectol is a farnesyltransferase (FTase) inhibitor with IC₅₀s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC₅₀ of 3.44 μM .

HY-146316

Topoisomerase II inhibitor 6	Topoisomerase	Cancer
Topoisomerase II inhibitor 6 (Compound 5), a tryptanthrin derivative, is a potent and selective inhibitor of topoisomerase II. Topoisomerase II inhibitor 6 exhibits antiproliferative activity on different tumor cell lines. Topoisomerase II inhibitor 6 blocks the cell cycle of CCRF-CEM in the G2 phase and induces DNA DSB. Topoisomerase II inhibitor 6 has the potential for the research of cancer diseases .

HY-133141

DI-87	Others	Cancer
DI-87 is an orally active and selective deoxycytidine kinase (dCK) inhibitor with an EC₅₀ of 10.2 nM. DI-87 has antitumor activity and is used in combination therapy against tumors expressing dCK .

HY-163435

Anticancer agent 201	Apoptosis Caspase PARP Bcl-2 Family	Cancer
Anticancer agent 201 (Compound 2f) has IC₅₀ values in the low micromolar range for multiple tumor cell lines. Anticancer agent 201 is highly cytotoxic to CCRF-CEM cells in vitro, inducing apotosis by activating caspase-3 in the intrinsic mitochondrial pathway and lysis of PARP, as well as reducing the expression of Bcl-2 and Bcl-XL proteins. Anticancer agent 201 can be used in cancer research .

HY-162074

Nipamovir	HIV	Infection
Nipamovir is a nitroimidazole prodrug. Nipamovir shows comparable antiviral activity to SAMT-247 (HY-102077) and NS-1040 in both cellular assays and a human ex vivo model of HIV infection, along with low toxicity. Nipamovir has EC₅₀ values of 3.64±3.28 and 3.23±2.81 μM for *CEM-SS/HIV-1RF* and hPBMC/HIV-192HT599, respectively .

HY-101248

GR-46611

5-HT Receptor Cancer

GR-46611 is a 5-HT_1D receptor agonist. GR-46611 can be used in the research of bladder hyperactivity, leukemia .

GR-46611	5-HT Receptor	Cancer
GR-46611 is a 5-HT_1D receptor agonist. GR-46611 can be used in the research of bladder hyperactivity, leukemia .

HY-113074

Glycolithocholic acid 3-sulfate Glycolithocholate sulfate; Sulfolithocholylglycine; SLCG	HIV Endogenous Metabolite	Infection Inflammation/Immunology
Glycolithocholic acid 3-sulfate (SLCG) is a cholic acid derivative and a metabolite of glycolithocholic acid. Glycolithocholic acid 3-sulfate inhibits replication of HIV-1 in vitro. Glycolithocholic acid 3-sulfate can be used for the research of HIV infection and gallbladder disease .

HY-151190

cis-4-Br-2,5-F2-PCPA S1024	Histone Demethylase	Cancer
cis-4-Br-2,5-F2-PCPA (S1024) is a selective inhibitor of lysine-specific demethylase 1 (LSD1), with a K_i value of 94 nM instead of 8.4 μM for LSD2. There is aberrant expression of LSD1 in cancer stem cells, cis-4-Br-2,5-F2-PCPA inhibits LSD1 cell proliferation and by increasing the level of dimethylated histone H3 at K4 (H3K4) in CCRF-CEM cells .

HY-120075

TJ191	Apoptosis	Cancer
TJ191 is a potent and specific anti-cancer agent that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells. TJ191 has no affects on the proliferation of other cancer cells or normal fibroblasts or immune cells. TJ191 can be used for cancer research .

HY-147901

KDM1/CDK1-IN-1	Histone Demethylase CDK Apoptosis Caspase	Cancer
KDM1/CDK1-IN-1 (compound 4) is a potent KDM1 and CDK1 inhibitor, with IC₅₀ values of 0.096 and 0.078 μM, respectively.KDM1/CDK1-IN-1 induces cell cycle arrest at G2/M phase and apoptosis in HOP-92 cells. KDM1/CDK1-IN-1 exhibits potent cytotoxic activity against the CCRF-CEM, HOP-92 and Hep-G2 cells, with IC₅₀ values of 16.34, 3.45 and 7.79 μM, respectively .

HY-146980

GLUT4-IN-2	Apoptosis GLUT	Cancer
GLUT4-IN-2 is a potent and selective GLUT4 inhibitor with IC₅₀s of 11.4 µM and 6.8 µM for GLUT1 and GLUT4, respectively. GLUT4-IN-2 induces cell apoptosis and cell cycle arrest at G0/G1phase. GLUT4-IN-2 shows potent antitumor activity .

Palicourein	Bacterial	Infection
Palicourein is a 37 amino acid cyclic polypeptide. Palicourein inhibits the in vitro cytopathic effects of HIV-1RF infection of CEM-SS cells with an EC₅₀ value of 0.1 μM and an IC₅₀ value of 1.5 μM .

Isoscopoletin 6-Hydroxy-7-methoxycoumarin	Structural Classification Classification of Application Fields Source classification Coumarins Plants Compositae Infection Monophenols other families Phenols Phenylpropanoids Disease Research Fields Sindora sumatrana Miq. Cancer	HBV
Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves. Isoscopoletin shows substantial inhibition against cell proliferation, with IC₅₀s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug resistant subline CEM/ADR5000, respectively . Isoscopoletin (6-Hydroxy-7-methoxycoumarin) possesses inhibitory activity against HBV replication .

Berkeleylactone F	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Antibiotic
Berkeleylactone F is an antibiotic macrolide compound. Berkeleylactone F showed modest inhibition of CCRF-CEM leukemia cells .

2',4'-Dihydroxy-3',6'-dimethoxychalcone	Flavonoids Chalcones Classification of Application Fields Polygonaceae Source classification Phenols Polyphenols Plants Disease Research Fields Perilla ocimoides L. Cancer	Others
2',4'-Dihydroxy-3',6'-dimethoxychalcone is a natural product that can be isolated from Polygonum Lapathifolium. 2',4'-Dihydroxy-3',6'-dimethoxychalcone inhibits the growth of CCRF-CEM leukaemia cells and CEM/ADR5000 cells, with IC₅₀ values of 10.67 and 18.60 μM, respectively .

Neocyclomorusin	Structural Classification Flavonoids Leguminosae Source classification Plants Other Flavonoids Erythrina sigmoidea Hua	Others
Neocyclomorusin (compound 6) is a flavonoid. Neocyclomorusin can be isolated from Erythrina sigmoidea. Neocyclomorusin inhibits the CCRF-CEM cell line with an IC50 value of 59.02 μM .

Oleandrigenin	Apocynaceae Structural Classification Natural Products Source classification Nerium indicum Mill. Plants	Na+/K+ ATPase
Oleandrigenin is a potent cardiotonic steroid. Oleandrigenin shows Na ⁺/K ⁺-ATP-ase inhibiting and cytotoxic activities .

Tectol	Infection Structural Classification other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields	Farnesyl Transferase Parasite
Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM . Tectol is a farnesyltransferase (FTase) inhibitor with IC₅₀s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC₅₀ of 3.44 μM .

Glycolithocholic acid 3-sulfate Glycolithocholate sulfate; Sulfolithocholylglycine; SLCG	Triterpenes Structural Classification Terpenoids Source classification Endogenous metabolite	HIV Endogenous Metabolite
Glycolithocholic acid 3-sulfate (SLCG) is a cholic acid derivative and a metabolite of glycolithocholic acid. Glycolithocholic acid 3-sulfate inhibits replication of HIV-1 in vitro. Glycolithocholic acid 3-sulfate can be used for the research of HIV infection and gallbladder disease .

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CEM

Inhibitors & Agonists

Peptides

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Natural
Products