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CFTR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CFTR (63) Apoptosis (1) Autophagy (21) Caspase (1) CDK (1) Chloride Channel (1) E1/E2/E3 Enzyme (1) Endogenous Metabolite (1) ERK (1) Fluorescent Dye (3) GSK-3 (1) GSNOR (1) Isotope-Labeled Compounds (1) JNK (1) Mitochondrial Metabolism (3) P-glycoprotein (3) PARP (1) Potassium Channel (4) PROTACs (1) SARS-CoV (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (9) Cardiovascular Disease (2) Endocrinology (11) Infection (1) Inflammation/Immunology (30) Metabolic Disease (6) Neurological Disease (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: CFTR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147315

CFTR corrector 9	CFTR	Others
CFTR corrector 9 (compound 42) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator. CFTR corrector 9 can be used for researching cystic fibrosis (CF) and other CFTR associated disorders .

HY-135279

CFTR corrector 4	CFTR	Inflammation/Immunology
CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis .

HY-16671

CFTR(inh)-172 5+ Cited Publications	CFTR Autophagy	Others
CFTR(inh)-172 is a potent and selective blocker of the *CFTR* chloride channel; reversibly inhibits CFTR short-circuit current in less than 2 minutes with a K_i of 300 nM.

HY-147249

CFTR corrector 8

CFTR Inflammation/Immunology

CFTR corrector 8 is a potent CFTR modulator. CFTR can be used in the research of cystic fibrosis .

CFTR corrector 8	CFTR	Inflammation/Immunology
CFTR corrector 8 is a potent *CFTR* modulator. CFTR can be used in the research of cystic fibrosis .

HY-155742

CFTR corrector 12	CFTR	Others
CFTR corrector 12 (compound 17C) is a bithiazole derivative, serving as CFTR corrector. CFTR corrector 12 has the ability to correct some folding defective mutants of the channel responsible for the control of chloride transport across the plasma membrane. CFTR corrector 12 recovers the α-sarcoglycan (α-SG) content in mutant cells .

HY-136939

CFTR corrector 6	CFTR	Metabolic Disease Inflammation/Immunology
CFTR corrector 6 is a potent potentiator of Cystic Fibrosis Transmembrane conductance Regulator (CFTR). CFTR corrector 6 has the potential for cystic fibrosis (CF) and other CFTR associated disorders research .

HY-153133

CFTR corrector 11

CFTR Others

CFTR corrector 11 (compound 133) is a CFTR corrector .

CFTR corrector 11	CFTR	Others
CFTR corrector 11 (compound 133) is a *CFTR* corrector .

HY-152264

CFTR activator 1	CFTR	Inflammation/Immunology
CFTR activator 1 is a potent and selective *CFTR* activator, with an EC₅₀ of 23 nM. CFTR activator 1 can be used to ameliorate dry eye disease .

HY-14179

PPQ-102 3 Publications Verification CFTR Inhibitor	CFTR	Others
PPQ-102 (CFTR Inhibitor) is a reversible CFTR inhibitor that completely inhibits *CFTR* chloride currents (IC₅₀ ~90 nM). PPQ-102 is not affected by membrane potential-dependent cell allocation or blocking efficiency (uncharged at physiological pH) and effectively prevents cyst enlargement in polycystic kidney disease .

HY-125381

CFTR corrector 2 1 Publications Verification	CFTR Autophagy	Inflammation/Immunology Cancer
CFTR corrector 2 is a cystic fibrosis transmembrane conductance corrector (CFTR), extracted from patent US20140274933 .

HY-RS02572

CFTR Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CFTR Human Pre-designed siRNA Set A contains three designed siRNAs for CFTR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CFTR Human Pre-designed siRNA Set A CFTR Human Pre-designed siRNA Set A

HY-RS02573

Cftr Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cftr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cftr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cftr Mouse Pre-designed siRNA Set A Cftr Mouse Pre-designed siRNA Set A

HY-RS02574

Cftr Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cftr Rat Pre-designed siRNA Set A contains three designed siRNAs for Cftr gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cftr Rat Pre-designed siRNA Set A Cftr Rat Pre-designed siRNA Set A

HY-158002

IDOR-4

CFTR Inflammation/Immunology

IDOR-4 is a type IV CFTR corrector. IDOR-4 restores F508del-CFTR trafficking to the cell surface .

IDOR-4	CFTR	Inflammation/Immunology
IDOR-4 is a type IV *CFTR* corrector. IDOR-4 restores F508del-CFTR trafficking to the cell surface .

HY-111680

Nesolicaftor 2 Publications Verification PTI-428	CFTR Autophagy	Endocrinology
Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier .

HY-15448

Tezacaftor 5+ Cited Publications VX-661	CFTR	Cancer
Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation .

HY-13017S

Ivacaftor-d9 VX-770-d₉	CFTR	Cancer
Ivacaftor-d₉ is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research[1].

HY-145603A

(R)-Vanzacaftor

(R)-VX-121
CFTR Others

(R)-Vanzacaftor ((R)-VX-121) is a regulator of cystic fibrosis transmembrane conduction regulator (CFTR) .

(R)-Vanzacaftor (R)-VX-121	CFTR	Others
(R)-Vanzacaftor ((R)-VX-121) is a regulator of cystic fibrosis transmembrane conduction regulator (CFTR) .

HY-109177

Icenticaftor QBW251	CFTR	Inflammation/Immunology
Icenticaftor (QBW251) is an orally active *CFTR* channel potentiator, with EC₅₀s of 79 nM and 497 nM for F508del and G551D CFTR, respectively. Icenticaftor can be used for chronic obstructive pulmonary disease (COPD) and cystic fibrosis research .

HY-109027

Cavosonstat N91115	GSNOR CFTR	Inflammation/Immunology
Cavosonstat (N91115) is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor. Cavosonstat is a CFTR stabilizer, and can be used for cystic fibrosis research .

HY-N6818

5,7,4'-Trimethoxyflavone	Apoptosis Caspase PARP Endogenous Metabolite CFTR	Cancer
5,7,4’-Trimethoxyflavone can be isolated from the medicinal plant Kaempferia parviflora (KP). 5,7,4’-Trimethoxyflavone is a *CFTR* activator and EC₅₀ is 64 μM. 5,7,4’-Trimethoxyflavone induces apoptosis, increases proteolytic activation of caspase-3, and degradation of ADP-ribose polymerase (PARP) protein. 5,7,4’-Trimethoxyflavone has antitumor activity. 5,7,4’-Trimethoxyflavone can be used to prevent skin aging and oxidative stress .

HY-13262

Lumacaftor 10+ Cited Publications VX-809; VRT 826809	CFTR Autophagy	Inflammation/Immunology
Lumacaftor (VX-809; VRT 826809) is a *CFTR* modulator that corrects the folding and trafficking of CFTR protein.

HY-13017

Ivacaftor 5 Publications Verification VX-770	CFTR Autophagy	Endocrinology
Ivacaftor (VX-770) is a potent and orally bioavailable *CFTR* potentiator, targeting G551D-CFTR and F508del-CFTR with EC₅₀s of 100 nM and 25 nM, respectively.

HY-111772

Elexacaftor Maximum Cited Publications 21 Publications Verification VX-445	CFTR Autophagy	Inflammation/Immunology
Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface .

HY-103369

PG01	CFTR	Endocrinology
PG01 is a potent *CFTR* Cl ^- channel potentiator. PG01 can correct gating defects of *CFTR* mutants, is effective on b>E193K, G970R and G551D (CFTR mutants) with K_d values of 0.22 μM, 0.45 μM and 1.94 μM, respectively. PG01 is also effective on ΔF508 (K_a of 0.3 μM). PG01 increases *ΔF508-CFTR* Cl ^- current after adding Forskolin .

HY-111099

GLPG1837

ABBV-974
CFTR Autophagy Others

GLPG1837 is a potent and reversible CFTR potentiator, with EC₅₀s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
HY-145126

CP-628006

CFTR Others

CP-628006, a small molecule CFTR potentiator, restores ATP-dependent channel gating to the cystic fibrosis mutant G551D-CFTR.

GLPG1837 ABBV-974	CFTR Autophagy	Others
GLPG1837 is a potent and reversible *CFTR* potentiator, with EC₅₀s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.

CP-628006	CFTR	Others
CP-628006, a small molecule *CFTR* potentiator, restores ATP-dependent channel gating to the cystic fibrosis mutant G551D-CFTR.

HY-13017S2

Ivacaftor-d18 VX-770-d₁₈	Autophagy CFTR	Endocrinology
Ivacaftor-d₁₈ is the deuterium labeled Ivacaftor[1]. Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively[2].

HY-115878

NJH-2-057

CFTR Others

NJH-2-057 is an EN523 OTUB1 recruiter linked to lumacaftor, a agent used to treat cystic fibrosis that binds ΔF508-CFTR.

NJH-2-057	CFTR	Others
NJH-2-057 is an EN523 OTUB1 recruiter linked to lumacaftor, a agent used to treat cystic fibrosis that binds *ΔF508-CFTR*.

HY-114725

VRT-532 CFpot-532	CFTR	Inflammation/Immunology
VRT-532 (CFpot-532) is a potent is a potent *CFTR* modulator. VRT-532 enhances channel activity in G551D-CFTR and intrinsic ATPase activity of G551D-CFTR. VRT-532 has the potential for the research of cystic fibrosis .

HY-119936

GLPG2451	CFTR Autophagy	Inflammation/Immunology
GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC₅₀ of 11.1 nM .

HY-13017S3

Ivacaftor-d4 VX-770-d4	CFTR	Endocrinology
Ivacaftor-d4 (VX-770-d4) is the deuterium labeled-Ivacaftor (HY-13017). Ivacaftor is a potent and orally active *CFTR* potentiator, targeting *G551D-CFTR* and *F508del-CFTR* with EC₅₀s of 100 nM and 25 nM, respectively .

HY-109187A

Posenacaftor sodium 1 Publications Verification PTI-801 sodium	CFTR	Inflammation/Immunology
Posenacaftor (PTI-801) sodium is a *cystic fibrosis transmembrane regulator (CFTR) protein* modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF) .

HY-109187

Posenacaftor PTI-801	CFTR	Inflammation/Immunology
Posenacaftor (PTI-801) is a *cystic fibrosis transmembrane regulator (CFTR) protein* modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF) .

HY-119179

UCCF-853

CFTR Cancer

UCCF-853 is a CFTR modulator .

UCCF-853	CFTR	Cancer
UCCF-853 is a *CFTR* modulator .

HY-109187B

(R)-Posenacaftor sodium (R)-PTI-801 sodium	CFTR	Inflammation/Immunology
(R)-Posenacaftor (R)-PTI-801) sodium is the R enantiomer of Posenacaftor. Posenacaftor is a *cystic fibrosis transmembrane regulator (CFTR) protein* modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF) .

HY-19778A

BPO-27 racemate

1 Publications Verification

CFTR Autophagy Inflammation/Immunology

BPO-27 racemate is a potent CFTR inhibitor with an IC₅₀ of 8 nM.

BPO-27 racemate 1 Publications Verification	CFTR Autophagy	Inflammation/Immunology
BPO-27 racemate is a potent *CFTR* inhibitor with an IC₅₀ of 8 nM.

HY-15448S

Tezacaftor-d4 VX-661-d₄	CFTR Autophagy	Cancer
Tezacaftor-d4 (VX-661-d4) is the deuterium-labeled Tezacaftor (HY-15448), a F508del CFTR corrector. Tezacaftor helps *CFTR* protein reach the cell surface .

HY-13017A

Ivacaftor benzenesulfonate VX-770 benzenesulfonate	CFTR Autophagy	Endocrinology
Ivacaftor benzenesulfonate is an orally bioavailable *CFTR* potentiator, used for cystic fibrosis treatment.

HY-18336

GlyH-101 3 Publications Verification	CFTR	Cardiovascular Disease
GlyH-101 is a potent *CFTR* inhibitor. GlyH-101 also is a potent and reversible inhibitor of the VSORC conductance. GlyH-101 shows antiproliferative activity. GlyH-101 inhibits CFTR-like current and VSORC current .

HY-111772A

(R)-Elexacaftor (R)-VX-445	CFTR	Inflammation/Immunology
(R)-Elexacaftor is an enantiomer of Elexacaftor (HY-111772). (R)-Elexacaftor is the Compound 37 from patent WO2018107100A1. (R)-Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR), the EC50 for CFTR dF508 is 0.29 uM .

HY-126394B

Bamocaftor potassium VX-659 potassium	CFTR	Endocrinology
Bamocaftor potassium is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore *F508del-CFTR* protein function. Bamocaftor potassium can be used combine with Tezacaftor (HY-15448) and Ivacaftor (HY-13017) in cystic fibrosis research .

HY-145603

Vanzacaftor

VX-121
CFTR Inflammation/Immunology

Vanzacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) for researching cystic fibrosis.

Vanzacaftor VX-121	CFTR	Inflammation/Immunology
Vanzacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) for researching cystic fibrosis.

HY-19970

KM11060 2 Publications Verification	CFTR Autophagy	Endocrinology
KM11060 is a corrector of the F508 deletion (F508del)-cystic fibrosis transmembrane conductance regulator (CFTR) trafficking defect. KM11060 can be used for the research of F508del-CFTR processing defect and development of cystic fibrosis research .

HY-126394

Bamocaftor VX-659	CFTR	Endocrinology
Bamocaftor (VX-659) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore *F508del-CFTR* protein function. Bamocaftor can be used combine with Tezacaftor (HY-15448) and Ivacaftor (HY-13017) in cystic fibrosis research .

HY-13017B

Ivacaftor hydrate

VX-770 hydrate
CFTR Autophagy Endocrinology

Ivacaftor hydrate (VX-770 hydrate) is an orally bioavailable CFTR potentiator, used for cystic fibrosis treatment.

Ivacaftor hydrate VX-770 hydrate	CFTR Autophagy	Endocrinology
Ivacaftor hydrate (VX-770 hydrate) is an orally bioavailable *CFTR* potentiator, used for cystic fibrosis treatment.

HY-13017S1

Ivacaftor-d19 VX-770-d₁₉	CFTR Autophagy	Endocrinology
Ivacaftor-d₉ is a potent *CFTR* modulator and exhibits an EC₅₀ value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research .

HY-14832

Ataluren

5+ Cited Publications

PTC124
CFTR Autophagy Metabolic Disease Cancer

Ataluren (PTC124) is an orally available CFTR-G542X nonsense allele inhibitor.

HY-150089

SRI-37240	CFTR	Inflammation/Immunology
SRI-37240 is a potent premature termination codons (PTCs) inhibitor. SRI-37240 suppresses *CFTR* nonsense mutations. SRI-37240 alters cellular translation termination at PTCs in HEK293T cells. SRI-37240 can also restore CFTR function in primary bronchial epithelial cells when combination with G418 .

HY-109152

Navocaftor

GLPG 3067; ABBV-3067
CFTR Others

Navocaftor (GLPG 3067), as a cystic fibrosis transmembrane regulator (CFTR), is a protein modulator (US 20200377491 Al, example 1) .

Cat. No.	Product Name	Type

HY-D1297

ER-Tracker Green

Fluorescent Dyes/Probes

ER-Tracker dye is a derivative of BODIPY series dyes coupled with Glibenclamide (HY-15206), highly selective binding to the endoplasmic reticulum, non-toxic to cells at low concentrations, this type of dye is an environmentally sensitive probe, and formaldehyde treatment can still retain part of the fluorescence, with high fluorescence life, good extinction coefficient and other characteristics. Glibenclamide is an atp-dependent K ⁺ channel blocker (Kir6, KATP) and CFTR Cl-channel blocker that binds in the endoplasmic reticulum. ER-Tracker is not suitable for staining cells after fixation .

HY-D1429

ER-Tracker Blue-White DPX

Fluorescent Dyes/Probes

HY-D1431

ER-Tracker Red

Fluorescent Dyes/Probes

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6818

5,7,4'-Trimethoxyflavone	Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Kaempferia parviflora Wall. ex Baker Plants Disease Research Fields Cancer Zingiberaceae	Apoptosis Caspase PARP Endogenous Metabolite CFTR
5,7,4’-Trimethoxyflavone can be isolated from the medicinal plant Kaempferia parviflora (KP). 5,7,4’-Trimethoxyflavone is a *CFTR* activator and EC₅₀ is 64 μM. 5,7,4’-Trimethoxyflavone induces apoptosis, increases proteolytic activation of caspase-3, and degradation of ADP-ribose polymerase (PARP) protein. 5,7,4’-Trimethoxyflavone has antitumor activity. 5,7,4’-Trimethoxyflavone can be used to prevent skin aging and oxidative stress .

HY-N5101

Kobusin	Natural Products Source classification Magnoliaceae Magnolia biondii Pamp. Plants	CFTR Chloride Channel
Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel .

Cat. No.	Product Name	Chemical Structure

HY-13017S

Ivacaftor-d9
Ivacaftor-d₉ is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research[1].

HY-13017S3

Ivacaftor-d4
Ivacaftor-d4 (VX-770-d4) is the deuterium labeled-Ivacaftor (HY-13017). Ivacaftor is a potent and orally active *CFTR* potentiator, targeting *G551D-CFTR* and *F508del-CFTR* with EC₅₀s of 100 nM and 25 nM, respectively .

HY-15448S

Tezacaftor-d4

Tezacaftor-d4 (VX-661-d4) is the deuterium-labeled Tezacaftor (HY-15448), a F508del CFTR corrector. Tezacaftor helps CFTR protein reach the cell surface .

HY-13017S2

Ivacaftor-d18
Ivacaftor-d₁₈ is the deuterium labeled Ivacaftor[1]. Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively[2].

HY-13017S1

Ivacaftor-d19
Ivacaftor-d₉ is a potent *CFTR* modulator and exhibits an EC₅₀ value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research .

HY-15206S

Glyburide-d11

Glyburide-d₁₁ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

HY-15206S1

Glyburide-d3

Glyburide-d₃ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

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CFTR

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Natural
Products