Search Result

Results for "

CGRP Receptor

" in MCE Product Catalog:

By Targets:	CGRP Receptor (30) Adenylate Cyclase (1) Amylin Receptor (2)
By Research Areas:	Cardiovascular Disease (15) Endocrinology (2) Infection (1) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (14)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Targets Recommended: CGRP Receptor

Cat. No.	Product Name	Target	Research Areas

HY-132131

Vazegepant hydrochloride Zavegepant hydrochloride; BHV-3500 hydrochloride	CGRP Receptor	Infection Inflammation/Immunology
Vazegepant (BHV-3500) hydrochloride is a highly affinity *CGRP* receptor antagonist (hCGRP K_i= 0.023 nM). Vazegepant hydrochloride is the first intranasal gepant for migraine. Vazegepant hydrochloride may be helpful in effective management of COVID-19 associated pulmonary inflammation.

HY-P1471

Adrenomedullin (AM) (22-52), human 22-52-Adrenomedullin (human)	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (AM) (22-52), human, an NH2 terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist, and also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat.

HY-P1471A

Adrenomedullin (AM) (22-52), human TFA 22-52-Adrenomedullin (human) (TFA)	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (AM) (22-52), human (22-52-Adrenomedullin human) TFA, an NH₂ terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist. Adrenomedullin (AM) (22-52), human also antagonizes the calcitonin generelated peptide *(CGRP)* receptor in the hindlimb vascular bed of the cat.

HY-P0209

Rat CGRP-(8-37)
CGRP Receptor Neurological Disease Cardiovascular Disease

Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist.
HY-114945

CGRP antagonist 2
CGRP Receptor Neurological Disease

CGRP antagonist 2 is a CGRP receptor antagonist. CGRP antagonist 2 can be used for pain relief.

Rat CGRP-(8-37)	CGRP Receptor	Neurological Disease Cardiovascular Disease
Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective **CGRP receptor** antagonist.

CGRP antagonist 2	CGRP Receptor	Neurological Disease
CGRP antagonist 2 is a **CGRP receptor** antagonist. CGRP antagonist 2 can be used for pain relief.

HY-112262

CGRP antagonist 1	CGRP Receptor	Neurological Disease Cardiovascular Disease
CGRP antagonist 1 is a highly potent **CGRP receptor antagonist with a K_i and IC₅₀** of 35 and 57 nM, respectively.

HY-32709

Telcagepant MK-0974	CGRP Receptor	Neurological Disease
Telcagepant (MK-0974) is an orally active calcitonin gene-related peptide (CGRP) receptor antagonist with K_is of 0.77 nM and 1.2 nM for human and rhesus CGRP receptors, respectively.

HY-P1913

Calcitonin Gene Related Peptide (CGRP) II, rat	CGRP Receptor	Cardiovascular Disease
Calcitonin Gene Related Peptide (CGRP) II, rat, a **CGRP receptor activator, is a potent and long-lasting vasodilator*. Calcitonin Gene Related Peptide (CGRP*) II can be used in the research of cardiovascular diseases.

HY-10095A

Olcegepant hydrochloride BIBN-4096 hydrochloride; BIBN4096BS hydrochloride	CGRP Receptor	Neurological Disease
Olcegepant hydrochloride (BIBN-4096 hydrochloride) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with IC₅₀ of 0.03 nM and with a K_i of 14.4 pM for human CGRP.

HY-10095

Olcegepant BIBN-4096; BIBN 4096BS	CGRP Receptor	Neurological Disease
Olcegepant (BIBN-4096) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with IC₅₀ of 0.03 nM and K_i of 14.4 pM for human CGRP.

HY-P1913A

Calcitonin Gene Related Peptide (CGRP) II, rat TFA	CGRP Receptor	Cardiovascular Disease
Calcitonin Gene Related Peptide (CGRP) II, rat TFA, a **CGRP receptor activator, is a potent and long-lasting vasodilator*. Calcitonin Gene Related Peptide (CGRP*) II TFA can be used in the research of cardiovascular diseases.

HY-P3689

[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat	CGRP Receptor Adenylate Cyclase	Others
[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat is a fragments 22-37 of rat calcitonin gene related peptide (CGRP), targeting **CGRP receptor and adenylate cyclase*. Calcitonin is mainly produced by thyroid C cells while CGRP* is secreted and stored in the nervous system.

HY-10301

MK-3207	CGRP Receptor	Neurological Disease
MK-3207 is an orally active, highly selective and species-specific **CGRP receptor antagonist (for human CGRP receptor: IC₅₀=0.12 nM; K_i**=0.024 nM). MK-3207 can be used for migraine studies.

HY-P1548

β-CGRP, human Human β-CGRP; CGRP-II (Human)	CGRP Receptor	Inflammation/Immunology Cardiovascular Disease
β-CGRP, human (Human β-CGRP) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC₅₀s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells.

HY-P1548B

β-CGRP, human acetate Human β-CGRP acetate; CGRP-II (Human) (acetate)	CGRP Receptor	Inflammation/Immunology Cardiovascular Disease
β-CGRP, human acetate (Human β-CGRP acetate) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC₅₀s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells.

HY-145353

HTL22562
CGRP Receptor Neurological Disease

HTL22562 is a calcitonin gene-related peptide (CGRP) receptor antagonist for acute research of migraine.

HTL22562	CGRP Receptor	Neurological Disease
HTL22562 is a calcitonin gene-related peptide (CGRP) receptor antagonist for acute research of migraine.

HY-P1548A

β-CGRP, human TFA Human β-CGRP TFA; CGRP-II (Human) (TFA)	CGRP Receptor	Inflammation/Immunology Cardiovascular Disease
β-CGRP, human TFA (Human β-CGRP TFA) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC₅₀s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells.

HY-134992

Vazegepant
Zavegepant; BHV-3500
CGRP Receptor Neurological Disease

Vazegepant is the first intranasal CGRP receptor antagonist for the study the acute research of migraine.

Vazegepant Zavegepant; BHV-3500	CGRP Receptor	Neurological Disease
Vazegepant is the first intranasal **CGRP receptor** antagonist for the study the acute research of migraine.

HY-P1014

HCGRP-(8-37) Human α-CGRP (8-37)	CGRP Receptor	Metabolic Disease Cardiovascular Disease
HCGRP-(8-37) is a human calcitonin gene-related peptide (hCGRP) fragment and also an antagonist of **CGRP receptor**.

HY-15498

Rimegepant BMS-927711	CGRP Receptor	Neurological Disease
Rimegepant (BMS-927711) is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a K_i of 0.027 nM and an IC₅₀ of 0.14 nM for hCGRP receptor.

HY-P1534

Adrenomedullin (1-50), rat	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (1-50), rat is a 50 amino acid peptide, which induces a selective arterial vasodilation via activation of **CGRP1 receptor**.

HY-P1766

Adrenomedullin (11-50), rat	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (11-50), rat is the C-terminal fragment (11-50) of rat adrenomedullin. Rat adrenomedullin induces a selective arterial vasodilation via CGRP1 receptors.

HY-12366

Ubrogepant MK-1602	CGRP Receptor	Neurological Disease Cardiovascular Disease
Ubrogepant (MK-1602) is a novel oral calcitonin gene-related peptide receptor (CGRP) antagonist in development for acute treatment of migraine.

HY-P9938

Erenumab	CGRP Receptor	Others
Erenumab is a fully human monoclonal antibody. Erenumab inhibits the calcitonin gene–related peptide (CGRP) receptor. Erenumab can be used for the prevention of episodic migraine.

HY-109022

Atogepant MK-8031; AGN-241689	CGRP Receptor	Neurological Disease
Atogepant (MK-8031) is an orally active and selective calcitonin gene–related peptide receptor (CGRP) antagonist. Atogepant can be used for researching migraine.

HY-P1393

AC 187	Amylin Receptor	Endocrinology
AC 187 is a potent and orally active amylin receptor antagonist with an IC₅₀ of 0.48 nM and a K_i of 0.275 nM. AC 187 shows more selective for amylin receptor than calcitonin and CGRP receptors. AC 187 has neuroprotective effects.

HY-P99017

Eptinezumab	CGRP Receptor	Others
Eptinezumab is a human monoclonal antibody. Eptinezumab binds to calcitonin gene-related peptide (CGRP) and blocks its binding to the receptor. Eptinezumab can be used for the prevention of migraine in adults.

HY-P1393A

AC 187 TFA	Amylin Receptor	Endocrinology
AC 187 TFA is a potent and orally active amylin receptor antagonist with an IC₅₀ of 0.48 nM and a K_i of 0.275 nM. AC 187 TFA shows more selective for amylin receptor than calcitonin and CGRP receptors. AC 187 TFA has neuroprotective effects.

HY-10302

MK-3207 Hydrochloride	CGRP Receptor	Neurological Disease
MK-3207 (Hydrochloride) is a potent and orally bioavailable **CGRP receptor antagonist with IC₅₀ of 0.12 nM and K_i** of 0.024 nM, and is highly selective versus human AM1, AM2, CTR, and AMY3.

HY-P1770

Adrenomedullin (16-31), human	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (16-31), human is amino acid residues 16-31 fragment of human adrenomedullin (hADM). Adrenomedullin has appreciable affinity for the CGRP1 receptor. Adrenomedullin (16-31), human possesses pressor activity in the systemic vascular bed of the rat, but not the cat.

HY-P1770A

Adrenomedullin (16-31), human TFA	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (16-31), human TFA is amino acid residues 16-31 fragment of human adrenomedullin (hADM). Adrenomedullin has appreciable affinity for the CGRP1 receptor. Adrenomedullin (16-31), human TFA possesses pressor activity in the systemic vascular bed of the rat, but not the cat.

HY-109022A

(3R,5R,6S)-Atogepant (3R,5R,6S)-MK-8031; (3R,5R,6S)-AGN-241689	CGRP Receptor	Neurological Disease
(3R,5R,6S)-Atogepant ((3R,5R,6S)-MK-8031) is the enantiomer of Atogepant (HY-109022). Atogepant is a calcitonin gene-related peptide receptor (CGRP) antagonist. Atogepant can be used for researching migraine.

Cat. No.	Product Name	Target	Research Area

HY-P1471

Adrenomedullin (AM) (22-52), human 22-52-Adrenomedullin (human)	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (AM) (22-52), human, an NH2 terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist, and also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat.

HY-P1471A

Adrenomedullin (AM) (22-52), human TFA 22-52-Adrenomedullin (human) (TFA)	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (AM) (22-52), human (22-52-Adrenomedullin human) TFA, an NH₂ terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist. Adrenomedullin (AM) (22-52), human also antagonizes the calcitonin generelated peptide *(CGRP)* receptor in the hindlimb vascular bed of the cat.

HY-P0209

Rat CGRP-(8-37)
CGRP Receptor Neurological Disease Cardiovascular Disease

Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist.

Rat CGRP-(8-37)	CGRP Receptor	Neurological Disease Cardiovascular Disease
Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective **CGRP receptor** antagonist.

HY-P1913

Calcitonin Gene Related Peptide (CGRP) II, rat	CGRP Receptor	Cardiovascular Disease
Calcitonin Gene Related Peptide (CGRP) II, rat, a **CGRP receptor activator, is a potent and long-lasting vasodilator*. Calcitonin Gene Related Peptide (CGRP*) II can be used in the research of cardiovascular diseases.

HY-P1913A

Calcitonin Gene Related Peptide (CGRP) II, rat TFA	CGRP Receptor	Cardiovascular Disease
Calcitonin Gene Related Peptide (CGRP) II, rat TFA, a **CGRP receptor activator, is a potent and long-lasting vasodilator*. Calcitonin Gene Related Peptide (CGRP*) II TFA can be used in the research of cardiovascular diseases.

HY-P3689

[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat	CGRP Receptor Adenylate Cyclase	Others
[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat is a fragments 22-37 of rat calcitonin gene related peptide (CGRP), targeting **CGRP receptor and adenylate cyclase*. Calcitonin is mainly produced by thyroid C cells while CGRP* is secreted and stored in the nervous system.

HY-P1548

β-CGRP, human Human β-CGRP; CGRP-II (Human)	CGRP Receptor	Inflammation/Immunology Cardiovascular Disease
β-CGRP, human (Human β-CGRP) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC₅₀s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells.

HY-P1548B

β-CGRP, human acetate Human β-CGRP acetate; CGRP-II (Human) (acetate)	CGRP Receptor	Inflammation/Immunology Cardiovascular Disease
β-CGRP, human acetate (Human β-CGRP acetate) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC₅₀s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells.

HY-P1548A

β-CGRP, human TFA Human β-CGRP TFA; CGRP-II (Human) (TFA)	CGRP Receptor	Inflammation/Immunology Cardiovascular Disease
β-CGRP, human TFA (Human β-CGRP TFA) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC₅₀s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells.

HY-P1014

HCGRP-(8-37) Human α-CGRP (8-37)	CGRP Receptor	Metabolic Disease Cardiovascular Disease
HCGRP-(8-37) is a human calcitonin gene-related peptide (hCGRP) fragment and also an antagonist of **CGRP receptor**.

HY-P1534

Adrenomedullin (1-50), rat	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (1-50), rat is a 50 amino acid peptide, which induces a selective arterial vasodilation via activation of **CGRP1 receptor**.

HY-P1766

Adrenomedullin (11-50), rat	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (11-50), rat is the C-terminal fragment (11-50) of rat adrenomedullin. Rat adrenomedullin induces a selective arterial vasodilation via CGRP1 receptors.

HY-P1393

AC 187	Amylin Receptor	Endocrinology
AC 187 is a potent and orally active amylin receptor antagonist with an IC₅₀ of 0.48 nM and a K_i of 0.275 nM. AC 187 shows more selective for amylin receptor than calcitonin and CGRP receptors. AC 187 has neuroprotective effects.

HY-P1393A

AC 187 TFA	Amylin Receptor	Endocrinology
AC 187 TFA is a potent and orally active amylin receptor antagonist with an IC₅₀ of 0.48 nM and a K_i of 0.275 nM. AC 187 TFA shows more selective for amylin receptor than calcitonin and CGRP receptors. AC 187 TFA has neuroprotective effects.

HY-P1770

Adrenomedullin (16-31), human	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (16-31), human is amino acid residues 16-31 fragment of human adrenomedullin (hADM). Adrenomedullin has appreciable affinity for the CGRP1 receptor. Adrenomedullin (16-31), human possesses pressor activity in the systemic vascular bed of the rat, but not the cat.

HY-P1770A

Adrenomedullin (16-31), human TFA	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (16-31), human TFA is amino acid residues 16-31 fragment of human adrenomedullin (hADM). Adrenomedullin has appreciable affinity for the CGRP1 receptor. Adrenomedullin (16-31), human TFA possesses pressor activity in the systemic vascular bed of the rat, but not the cat.

Cat. No.	Product Name	Target	Research Area

HY-P9938

Erenumab	CGRP Receptor	Others
Erenumab is a fully human monoclonal antibody. Erenumab inhibits the calcitonin gene–related peptide (CGRP) receptor. Erenumab can be used for the prevention of episodic migraine.

HY-P99017

Eptinezumab	CGRP Receptor	Others
Eptinezumab is a human monoclonal antibody. Eptinezumab binds to calcitonin gene-related peptide (CGRP) and blocks its binding to the receptor. Eptinezumab can be used for the prevention of migraine in adults.