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Isoforms Recommended:	Chk2

Results for "

CHK2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Apoptosis (10) Aryl Hydrocarbon Receptor (1) ATM/ATR (2) Aurora Kinase (1) c-Fms (1) CDK (1) Checkpoint Kinase (Chk) (20) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (2) FGFR (1) FLT3 (1) Phosphatase (1) RET (1) Src (1) VEGFR (1)
By Research Areas:	Cancer (24) Neurological Disease (1)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13946

BML-277

5+ Cited Publications

CHK2 Inhibitor II
Checkpoint Kinase (Chk) Apoptosis Cancer

BML-277 is a selective checkpoint kinase 2 (Chk2) inhibitor with an IC₅₀ of 15 nM.

BML-277 5+ Cited Publications CHK2 Inhibitor II	Checkpoint Kinase (Chk) Apoptosis	Cancer
BML-277 is a selective checkpoint kinase 2 (Chk2) inhibitor with an IC₅₀ of 15 nM.

HY-112477

Chk2-IN-1	Checkpoint Kinase (Chk)	Cancer
Chk2-IN-1 (compound 1) is a potent and selective inhibitor of checkpoint kinase 2 (Chk2), with IC₅₀s of 13.5 nM and 220.4 nM for *Chk2* and *Chk1, respectively. Chk2-IN-1 can elicit a strong ataxia telangiectasia mutated (ATM)-dependent Chk2*-mediated radioprotection effect .

HY-106009

VRX0466617	Checkpoint Kinase (Chk)	Cancer
VRX0466617, a selective *Chk2* inhibitor, inhibits the phosphorylation of Chk2 Ser ¹⁹ and Ser ^33-35. VRX0466617 can be used in the study of cancer .

HY-119699

PV1115	Checkpoint Kinase (Chk)	Cancer
PV1115 is a potent and highly selective *Chk2* inhibitor with an IC₅₀ of 0.14 nM, 66000 nM, >100000 nM for Chk2, Chk1 and RSK2, respectively. PV1115 is situated within the ATP-binding pocket of Chk2 .

HY-P5961

Chktide

Checkpoint Kinase (Chk) Cancer

Chktide is a substrate for CHK1 and CHK2. Chktide can be used in kinase assays ^[2].

Chktide	Checkpoint Kinase (Chk)	Cancer
Chktide is a substrate for CHK1 and CHK2. Chktide can be used in kinase assays ^[2].

HY-103366

NSC 109555 ditosylate	Checkpoint Kinase (Chk)	Cancer
NSC 109555 ditosylate is a potent, selective, ATP-competitive checkpoint kinase 2 (Chk2) inhibitor with an IC₅₀ of 240 nM. NSC 109555 ditosylate can be used for the research of cancer .

HY-125203

PV-1019 NSC 744039	Checkpoint Kinase (Chk)	Cancer
PV-1019 (NSC 744039) is a potent, selective *Chk2* inhibitor with an IC₅₀ value of 24 nM. PV-1019 inhibits the Topotecan (HY-13768)-induced Chk2 autophosphorylation. PV-1019 inhibits IR-induced apoptosis .

HY-U00345

CHK-IN-1

Checkpoint Kinase (Chk) Cancer

CHK-IN-1 is an inhibitor of CHK1 and CHK2, with anti-proliferative activities.

CHK-IN-1	Checkpoint Kinase (Chk)	Cancer
CHK-IN-1 is an inhibitor of *CHK1* and *CHK2*, with anti-proliferative activities.

HY-14715B

CCT241533 hydrochloride 4 Publications Verification	Checkpoint Kinase (Chk)	Cancer
CCT241533 hydrochloride is a potent and selective *CHK2* inhibitor with an IC₅₀ of 3 nM and a K_i of 1.16 nM .

HY-14715

CCT241533

Checkpoint Kinase (Chk) Cancer

CCT241533 is a potent and selective ATP competitive inhibitor of CHK2 with an IC₅₀ of 3 nM and K_i of 1.16 nM .

CCT241533	Checkpoint Kinase (Chk)	Cancer
CCT241533 is a potent and selective ATP competitive inhibitor of *CHK2* with an IC₅₀ of 3 nM and K_i of 1.16 nM .

HY-110331

CCT241533 dihydrochloride	Checkpoint Kinase (Chk)	Cancer
CCT241533 dihydrochloride is a potent and selective ATP competitive inhibitor of *CHK2* with an IC₅₀ of 3 nM and K_i of 1.16 nM .

HY-18942

VER-00158411

VER-00158411 is a checkpoint kinase 1 (CHK1) and CHK2 inhibitor with IC₅₀ values of 4.4 nM and 4.5 nM, respectively .

VER-00158411
VER-00158411 is a checkpoint kinase 1 (CHK1) and *CHK2* inhibitor with IC₅₀ values of 4.4 nM and 4.5 nM, respectively .

HY-10032

PF 477736 5 Publications Verification PF 00477736	Checkpoint Kinase (Chk) VEGFR Src c-Fms Aurora Kinase FGFR FLT3 RET CDK	Cancer
PF 477736 (PF 00477736) is a potent, selective and ATP-competitive inhibitor of *Chk1, with a K_i* of 0.49 nM, it is also a *Chk2* inhibitor, with a K_i of 47 nM. PF 477736 shows <100-fold selectivity for Chk1 over *VEGFR2, Fms, Yes, Aurora-A, FGFR3, Flt3, and Ret* (IC₅₀=8 (K_i), 10, 14, 23, 23, 25, and 39 nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo ^[2].

HY-157954

WRN inhibitor 6	DNA/RNA Synthesis Apoptosis	Cancer
WRN inhibitor 6 (compound 3ci) is a potent WRN inhibitor. WRN inhibitor 6 induces apoptosis. WRN inhibitor 6 increases the expression of p-p53, P-Chk2, γH2AX expression .

HY-15532

SCH900776 5+ Cited Publications MK-8776	Checkpoint Kinase (Chk)	Cancer
SCH900776 (MK-8776) is a potent, selective and orally bioavailable inhibitor of checkpoint kinase1 (Chk1) with an IC₅₀ of 3 nM. SCH900776 shows 50- and 500-fold selectivity over CDK2 and Chk2, respectively ^[2].

HY-18174

Prexasertib Maximum Cited Publications 17 Publications Verification LY2606368	Checkpoint Kinase (Chk) Apoptosis	Cancer
Prexasertib (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K_i of 0.9 nM and an IC₅₀ of <1 nM. Prexasertib inhibits CHK2 (IC₅₀=8 nM) and RSK1 (IC₅₀=9 nM). Prexasertib causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib shows potent anti-tumor activity ^[2].

HY-18174A

Prexasertib dihydrochloride Maximum Cited Publications 17 Publications Verification LY2606368 dihydrochloride	Checkpoint Kinase (Chk) Apoptosis	Cancer
Prexasertib dihydrochloride (LY2606368 dihydrochloride) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K_i of 0.9 nM and an IC₅₀ of <1 nM. Prexasertib dihydrochloride inhibits CHK2 (IC₅₀=8 nM) and RSK1 (IC₅₀=9 nM). Prexasertib dihydrochloride causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib dihydrochloride shows potent anti-tumor activity ^[2].

HY-18174B

Prexasertib Mesylate Hydrate LY2606368 Mesylate Hydrate; LY2940930	Checkpoint Kinase (Chk) Apoptosis	Cancer
Prexasertib Mesylate Hydrate (LY2606368 Mesylate Hydrate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K_i of 0.9 nM and an IC₅₀ of <1 nM. Prexasertib Mesylate Hydrate inhibits CHK2 (IC₅₀=8 nM) and RSK1 (IC₅₀=9 nM). Prexasertib Mesylate Hydrate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib Mesylate Hydrate shows potent anti-tumor activity ^[2].

HY-18174C

Prexasertib mesylate LY2606368 mesylate	Checkpoint Kinase (Chk) DNA/RNA Synthesis Apoptosis	Cancer
Prexasertib mesylate (LY2606368 mesylate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K_i of 0.9 nM and an IC₅₀ of <1 nM. Prexasertib mesylate inhibits CHK2 (IC₅₀=8 nM) and RSK1 (IC₅₀=9 nM). Prexasertib mesylate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib mesylate shows potent anti-tumor activity ^[2].

HY-15883

GNE-900	Checkpoint Kinase (Chk) Apoptosis	Cancer
GNE-900 is a an ATP-competitive, selective, and orally active *ChK1* inhibitor with IC₅₀s of 0.0011, 1.5 µM for ChKl, ChK2, respectively. GNE-900 abrogates the G2-M checkpoint, enhances DNA damage, and induces Apoptosis. gemcitabine (HY-17026) and GNE-900 administration shows anti-tumor activity .

HY-18174E

Prexasertib dimesylate Maximum Cited Publications 17 Publications Verification LY2606368 dimesylate	Checkpoint Kinase (Chk) Apoptosis	Cancer
Prexasertib dimesylate (LY2606368 dimesylate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K_i of 0.9 nM and an IC₅₀ of <1 nM. Prexasertib dimesylate inhibits CHK2 (IC₅₀=8 nM) and RSK1 (IC₅₀=9 nM). Prexasertib dimesylate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib dimesylate shows potent anti-tumor activity ^[2].

HY-100195

SAR-020106
SAR-020106 is an ATP-competitive, potent, and selective *CHK1* inhibitor with an IC₅₀ of 13.3 nM for human CHK1. SAR-020106 shows excellent selectivity over CHK2. SAR-020106 significantly enhances the cell killing of Gemcitabine and SN38 by 3- to 29-fold in several colon tumor lines and in a p53-dependent fashion. SAR-020106 can enhance antitumor activity with selected anticancer agents ^[2].

HY-117102

ANI-7	Aryl Hydrocarbon Receptor Checkpoint Kinase (Chk)	Cancer
ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF-7 breast cancer cells with a GI₅₀ of 0.56 μM. ANI-7 induces CYP1-metabolizing mono-oxygenases by activating AhR pathway, and also induces DNA damage, checkpoint Kinase 2 (Chk2) activation, S-phase cell cycle arrest, and cell death in sensitive breast cancer cell lines ^[2] .

HY-14429

(-)-Irofulven MGI 114; 6-Hydroxymethylacylfulvene; NSC 683863	DNA Alkylator/Crosslinker Apoptosis	Cancer
(-)-Irofulven (MGI 114), an Illudin S analog, is a DNA alkylating agent. (-)-Irofulven inhibits the replication of DNA, induces tumor cells apoptosis, and has potent antitumor activity ^[2].

HY-117693

Mirin 1 Publications Verification	ATM/ATR	Cancer
Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor. Mirin prevents MRN-dependent activation of ATM (IC₅₀=12 μM) without affecting ATM protein kinase activity, and it inhibits Mre11-associated exonuclease activity. Mirin abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells. Mirin prevents ATM activation in response to DNA double-strand breaks (DSBs) and blocks homology-directed repair (HDR) in mammalian cells .

HY-103241

Ro 90-7501 1 Publications Verification	Amyloid-β ATM/ATR Phosphatase Apoptosis	Neurological Disease Cancer
Ro 90-7501 is an amyloid β₄₂ (Aβ₄₂) fibril assembly inhibitor that reduces Aβ₄₂-induced cytotoxicity (EC₅₀ of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response ^[2]. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner . Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells .

Cat. No.	Product Name	Target	Research Area

HY-P5961

Chktide

Checkpoint Kinase (Chk) Cancer

Chktide is a substrate for CHK1 and CHK2. Chktide can be used in kinase assays ^[2].

Chktide	Checkpoint Kinase (Chk)	Cancer
Chktide is a substrate for CHK1 and CHK2. Chktide can be used in kinase assays ^[2].

Recombinant Proteins Recommended:

Checkpoint Kinase 2 (Chk2)

Species:	Human (1) Mouse (1)
Tag:	His (1) GST (2)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P75348

	CHEK2 Protein, Mouse (sf9, His-GST) Serine/threonine-protein kinase CHK2; Hucds1; Checkpoint kinase 2; CDS1; CHK2; RAD53	Mouse	Sf9 insect cells
	CHEK2 is a serine/threonine protein kinase that coordinates cellular responses to DNA double-strand breaks by activating cell cycle arrest, DNA repair, and apoptosis. It phosphorylates effectors and inhibits CDC25A, CDC25B, and CDC25C, thereby enhancing CDK cyclin inhibition and cell cycle arrest. CHEK2 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CHEK2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of CHEK2 Protein, Mouse (sf9, His-GST) is 546 a.a., with molecular weight of ~90 kDa.

HY-P75349

	CHEK2 Protein, Human (sf9, GST) Serine/threonine-protein kinase CHK2; Hucds1; Checkpoint kinase 2; CDS1; CHK2; RAD53	Human	Sf9 insect cells
	The CHEK2 protein is a serine/threonine protein kinase that critically coordinates checkpoint-mediated cell cycle arrest, DNA repair activation, and apoptosis in response to DNA double-strand breaks. Activated CHEK2 phosphorylates CDC25A, CDC25B, and CDC25C, inhibiting their phosphatase activities and preventing the CDK-cyclin complex from activating cell cycle progression. CHEK2 Protein, Human (sf9, GST) is the recombinant human-derived CHEK2 protein, expressed by Sf9 insect cells , with GST labeled tag.


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Cat. No.	Product Name	Application	Reactivity

HY-P80799

*Phospho-Chk2* (Thr68) Antibody** CHEK2; CDS1; CHK2; RAD53; Serine/threonine-protein kinase CHK2; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2	WB, ICC/IF, IHC-P	Human, Mouse, Rat
Phospho-Chk2 (Thr68) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 61 kDa, targeting to Phospho-Chk2 (Thr68). It can be used for WB,ICC/IF,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P80083

Chk2 Antibody	WB, ICC/IF, IHC-P, IP	Human
Chk2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 61 kDa, targeting to Chk2. It can be used for WB,ICC/IF,IHC-P,IP assays with tag free, in the background of Human.

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