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Results for "

CI

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (2) Adenosine Deaminase (1) Adenosine Receptor (1) AIM2 (1) Amino Acid Derivatives (5) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (13) Antifolate (4) Apoptosis (8) Autophagy (4) Bacterial (13) Biochemical Assay Reagents (7) Carbonic Anhydrase (2) Chloride Channel (1) Cholecystokinin Receptor (2) Cytochrome P450 (6) Dihydrofolate reductase (DHFR) (3) DNA Stain (1) DNA/RNA Synthesis (9) Drug Metabolite (1) EAAT (1) EGFR (2) Endogenous Metabolite (4) Endothelin Receptor (1) Estrogen Receptor/ERR (1) Ferroptosis (2) Fluorescent Dye (5) Guanylate Cyclase (2) HDAC (1) Histamine Receptor (1) HIV (2) HMG-CoA Reductase (HMGCR) (2) iGluR (1) Influenza Virus (2) Isotope-Labeled Compounds (3) Leukotriene Receptor (2) mAChR (3) MEK (2) MicroRNA (2) Microtubule/Tubulin (2) Mitochondrial Metabolism (4) Monoamine Oxidase (2) NF-κB (2) NO Synthase (2) Nucleoside Antimetabolite/Analog (1) Orthopoxvirus (2) Oxidative Phosphorylation (2) Parasite (3) Phosphatase (1) Phosphodiesterase (PDE) (1) Potassium Channel (1) PPAR (4) Prolyl Endopeptidase (PREP) (1) Prostaglandin Receptor (2) Pyruvate Kinase (1) Reactive Oxygen Species (2) SARS-CoV (1) TNF Receptor (1)
By Research Areas:	Cancer (31) Cardiovascular Disease (8) Endocrinology (2) Infection (20) Inflammation/Immunology (12) Metabolic Disease (11) Neurological Disease (13)

By Targets:

Acyltransferase (2)

Adenosine Deaminase (1)

Adenosine Receptor (1)

AIM2 (1)

Amino Acid Derivatives (5)

Angiotensin-converting Enzyme (ACE) (2)

Antibiotic (13)

Antifolate (4)

Apoptosis (8)

Autophagy (4)

Bacterial (13)

Biochemical Assay Reagents (7)

Carbonic Anhydrase (2)

Chloride Channel (1)

Cholecystokinin Receptor (2)

Cytochrome P450 (6)

Dihydrofolate reductase (DHFR) (3)

DNA Stain (1)

DNA/RNA Synthesis (9)

Drug Metabolite (1)

EAAT (1)

EGFR (2)

Endogenous Metabolite (4)

Endothelin Receptor (1)

Estrogen Receptor/ERR (1)

Ferroptosis (2)

Fluorescent Dye (5)

Guanylate Cyclase (2)

HDAC (1)

Histamine Receptor (1)

HIV (2)

HMG-CoA Reductase (HMGCR) (2)

iGluR (1)

Influenza Virus (2)

Isotope-Labeled Compounds (3)

Leukotriene Receptor (2)

mAChR (3)

MEK (2)

MicroRNA (2)

Microtubule/Tubulin (2)

Mitochondrial Metabolism (4)

Monoamine Oxidase (2)

NF-κB (2)

NO Synthase (2)

Nucleoside Antimetabolite/Analog (1)

Orthopoxvirus (2)

Oxidative Phosphorylation (2)

Parasite (3)

Phosphatase (1)

Phosphodiesterase (PDE) (1)

Potassium Channel (1)

PPAR (4)

Prolyl Endopeptidase (PREP) (1)

Prostaglandin Receptor (2)

Pyruvate Kinase (1)

Reactive Oxygen Species (2)

SARS-CoV (1)

TNF Receptor (1)

By Research Areas:

Cancer (31)

Cardiovascular Disease (8)

Endocrinology (2)

Infection (20)

Inflammation/Immunology (12)

Metabolic Disease (11)

Neurological Disease (13)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0477

Quinapril hydrochloride CI-906	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Quinapril (hydrochloride) (CI-906) is a proagent that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications.

HY-100161

CI-943

(±)-CI-943
Others Neurological Disease

CI-943 is a potential antipsychotic agent.

CI-943 (±)-CI-943	Others	Neurological Disease
CI-943 is a potential antipsychotic agent.

HY-146364

CI-39	HIV	Infection
CI-39 is an antiviral natural product. CI-39 is an NNRTI (non-nucleoside reverse transcriptase inhibit) antiviral agent with an EC₅₀ of 3.40 µM and an CC₅₀ of >30 µM for wild type HIV-1. CI-39 inhibits HIV-1 RT DNA polymerase and ribonuclease H activitiessup .

HY-105226

CI-988 PD134308	Cholecystokinin Receptor	Neurological Disease Cancer
CI-988 (PD134308) is a potent, selective and orally active CCK2R (cholecystokinin 2 receptor) antagonist with an IC₅₀ of 1.7 nM for mouse cortex CCK2. CI-988 shows >1600-fold selectivity for CCK2 over CCK1 receptor. CI-988 has anxiolytic and anti-tumor effects .

HY-105226B

CI-988 hemihydrate PD134308 hemihydrate	Cholecystokinin Receptor	Neurological Disease Cancer
CI-988 hemihydrate (PD134308) is a potent, selective and orally active CCK2R (cholecystokinin 2 receptor) antagonist with an IC₅₀ of 1.7 nM for mouse cortex CCK2. CI-988 hemihydrate shows >1600-fold selectivity for CCK2 over CCK1 receptor. CI-988 hemihydrate has anxiolytic and anti-tumor effects .

HY-103459

CI-1020 PD156707	Endothelin Receptor	Cardiovascular Disease
CI-1020 (PD156707) is an orally active and selective antagonist targeting endothelin (ET_A) with an IC₅₀ value of 0.3 nM. CI-1020 blocks intimal hyperplasia in human saphenous veins completely in organ culture. CI 1020 inhibits hypoxic pulmonary hypertension and blocks ET-1-induced pressor responses following oral administration .

HY-A0006

Pentostatin 5+ Cited Publications CI-825; DeoxycoformyCIn	Adenosine Deaminase Antibiotic	Cancer
Pentostatin (CI-825; Deoxycoformycin) is an irreversible inhibitor of adenosine deaminase with K_i of 2.5 pM.

HY-B0308

Sparfloxacin

CI-978; AT-4140
Bacterial Antibiotic Infection

Sparfloxacin (CI-978) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity .

Sparfloxacin CI-978; AT-4140	Bacterial Antibiotic	Infection
Sparfloxacin (CI-978) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity .

HY-139801

Indolapril hydrochloride CI-907	Angiotensin-converting Enzyme (ACE)	Metabolic Disease
Indolapril hydrochloride (CI-907) is an orally active nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor. Indolapril hydrochloride is highly specific in suppressing the contractile or pressor responses to Angiotensin I. Indolapril hydrochloride is a potent antihypertensive agent .

HY-106702

Fostriecin sodium CI-920	Antibiotic Phosphatase	Cancer
Fostriecin (sodium) (compound 1, CI-920) is an antibiotic with a cytotoxic activity. Fostriecin (sodium) is also an inhibitor of protein phosphatase including PP4 (IC₅₀= 3 nM)and PP2 (IC₅₀=1.5 nM) .

HY-139010

Merafloxacin CI-934	SARS-CoV	Infection
Merafloxacin (CI-934), a fluoroquinolone antibacterial agent, is a selective programmed -1 ribosomal frameshifting (-1 PRF) inhibitor of beta coronaviruses. Merafloxacin exhibits in vitro activity against gram-positive and gram-negative bacteria .

HY-107650

Milameline hydrochloride CI 979 hydrochloride; RU 35926 hydrochloride	mAChR	Neurological Disease
Milameline (CI 979) hydrochloride is a muscarinic receptor agonist that improves cognition .

HY-50295

CI-1040 15+ Cited Publications PD 184352	MEK Apoptosis	Cancer
CI-1040 (PD 184352) is an orally active, highly specific, small-molecule inhibitor of MEK with an IC₅₀ of 17 nM for MEK1.

HY-101438A

Darbufelone mesylate CI-1004 mesylate	Prostaglandin Receptor Leukotriene Receptor	Inflammation/Immunology Endocrinology
Darbufelone mesylate (CI-1004 mesylate) is a dual inhibitor of cellular PGF_2α and LTB₄ production. Darbufelone potently inhibits PGHS-2 (IC₅₀ = 0.19 μM) but is much less potent with PGHS-1 (IC₅₀= 20 μM).

HY-115231

ci-IP3/PM

Others Others

ci-IP3/PM is a caged and cell permeable derivative of IP3. ci-IP3/PM can induce Ca ²⁺ release from internal stores .

ci-IP3/PM	Others	Others
ci-IP3/PM is a caged and cell permeable derivative of IP3. ci-IP3/PM can induce Ca ²⁺ release from internal stores .

HY-17455

Pramiracetam CI-879 free base	Prolyl Endopeptidase (PREP)	Neurological Disease
Pramiracetam (CI-879 free base) is a PREP (prolyl endopeptidase) inhibitor. Pramiracetam improves cognitive impairment caused by traumatic brain injury. Pramiracetam can be used in the study of neurodegenerative diseases .

HY-U00364

CI-949	Histamine Receptor Prostaglandin Receptor Leukotriene Receptor	Inflammation/Immunology Endocrinology
CI-949 is an allergic mediator release inhibitor, which inhibits histamine, leukotriene C₄/D₄ (LTC₄/LTD₄), and thromboxane B₂ (TXB₂) release with IC₅₀s of 11.4 μM, 0.5 μM and 0.1 μM, respectively.

HY-100246

CI-1044 PD-189659	Phosphodiesterase (PDE)	Inflammation/Immunology
CI-1044 is an orally active PDE4 inhibitor with IC₅₀s of 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3, respectively.

HY-118047

CI 972 anhydrous	Nucleoside Antimetabolite/Analog	Inflammation/Immunology
CI 972 anhydrous is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (K_i=0.83 μM) under development as a T cell-selective immunosuppressive agent .

HY-10367A

Canertinib dihydrochloride 5+ Cited Publications CI-1033 dihydrochloride; PD-183805 dihydrochloride	EGFR Orthopoxvirus	Infection Cancer
Canertinib dihydrochloride (CI-1033 dihydrochloride) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC₅₀s of 7.4 and 9 nM. Canertinib dihydrochloride is active against vaccinia virus respiratory infection in mice .

HY-10367

Canertinib 5+ Cited Publications CI-1033; PD-183805	EGFR Orthopoxvirus	Infection Cancer
Canertinib (CI-1033;PD-183805) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC₅₀s of 7.4 and 9 nM. Canertinib is active against vaccinia virus respiratory infection in mice .

HY-10373

Trimetrexate CI-898	Dihydrofolate reductase (DHFR) Antibiotic Antifolate Parasite Bacterial DNA/RNA Synthesis	Infection Cancer
Trimetrexate (CI-898) is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC₅₀ values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate can also inhibit the growth of various cancer cells. Trimetrexate can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer .

HY-10373A

Trimetrexate trihydrochloride CI-898 trihydrochloride	Dihydrofolate reductase (DHFR) Antibiotic Antifolate Parasite Bacterial DNA/RNA Synthesis	Infection
Trimetrexate (CI-898) trihydrochloride is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC₅₀ values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate trihydrochloride can also inhibit the growth of various cancer cells. Trimetrexate trihydrochloride can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer .

HY-13215

Avasimibe 5+ Cited Publications CI-1011; PD-148515	Acyltransferase	Cancer
Avasimibe (CI-1011; PD-148515) is an orally active acyl coenzyme A-cholesterol acyltransferase (ACAT; also called SOAT)) inhibitor with IC₅₀s of 24 and 9.2 µM for ACAT1 and ACAT2, respectively . Avasimibe can be used for the research of prostate cancer .

HY-16909

Leptomycin B 5 Publications Verification CI 940; LMB
Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle .

HY-17379

Atorvastatin hemicalcium salt 25+ Cited Publications CI-981; Atorvastatin hemicalCIum	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Metabolic Disease Inflammation/Immunology
Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium salt inhibits human SV-SMC proliferation and invasion with IC₅₀s of 0.39 μM and 2.39 μM, respectively .

HY-124254

C.I. Vat Yellow 2

Fluorescent Dye Others

C.I. Vat Yellow 2 is an agent of yellow dye and can also be used for the paper dyeing .

C.I. Vat Yellow 2	Fluorescent Dye	Others
C.I. Vat Yellow 2 is an agent of yellow dye and can also be used for the paper dyeing .

HY-B0919

Azaserine 2 Publications Verification CI-337; O-Diazoacetyl-L-serine; P-165	Bacterial Antibiotic DNA/RNA Synthesis	Infection Cancer
Azazerine (CI-337) is a competitive inhibitor of glutamine amidotransferase. Azaserine is an antibiotic, it shows antibacterial activities. Azazerine shows anti-tumor activities and it may also act as a tumor inducer. Azazerine can be used for the research of cancer and infection .

HY-10373B

Trimetrexate isethionate CI-898 isethionate	Dihydrofolate reductase (DHFR) Antibiotic Antifolate Parasite Bacterial DNA/RNA Synthesis	Infection Cancer
Trimetrexate (CI-898) isethionate is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC₅₀ values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate isethionate can also inhibit the growth of various cancer cells. Trimetrexate isethionate can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer .

HY-100032

PD 117519 CI947	Adenosine Receptor	Neurological Disease
PD 117519 (CI947) is an A_2A adenosine agonist which has shown oral antihypertensive activity in pharmacological animal models .

HY-107572

PD 128042 CI 976	Acyltransferase	Metabolic Disease
PD 128042 (CI 976) is a potent, orally active, and selective inhibitor of ACAT (acyl coenzyme A:cholesterol acyltransferase) with an IC₅₀s of 73 nM. PD 128042 is also a potent LPAT (lysophospholipid acyltransferase) inhibitor. PD 128042 inhibits Golgi-associated LPAT activity (IC₅₀=15 μM). PD 128042 inhibits multiple membrane trafficking steps, including ones found in the endocytic and secretory pathway .

HY-17379R

Atorvastatin hemicalcium salt (Standard) CI-981 (Standard); Atorvastatin hemicalCIum (Standard)	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Metabolic Disease Inflammation/Immunology Cancer
Atorvastatin (hemicalcium salt) (Standard) is the analytical standard of Atorvastatin (hemicalcium salt). This product is intended for research and analytical applications. Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium salt inhibits human SV-SMC proliferation and invasion with IC₅₀s of 0.39 μM and 2.39 μM, respectively .

HY-D0293

Acid Blue 1 Xylene Blue; C.I. ACId Blue 1	Biochemical Assay Reagents	Others
C.I. Acid Blue 1 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-B1359

Methylene blue trihydrate 10+ Cited Publications C.I. Basic Blue 9 trihydrate
Methylene blue trihydrate (C.I. Basic Blue 9 trihydrate) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue trihydrate is a vasopressor and is often used as a dye in several medical procedures. Methylene blue trihydrate has antinociception, antimalarial, antidepressant and anxiolytic activity effects. Methylene Blue trihydrate has the potential for methemoglobinemias, neurodegenerative disorders and ifosfamide-induced encephalopathytreatment .

HY-Y0057

NSC 13138

CInchoninic aCId (6CI,7CI,8CI); 4-Carboxyquinoline
Endogenous Metabolite Metabolic Disease

NSC 13138 is an endogenous metabolite.

NSC 13138 CInchoninic aCId (6CI,7CI,8CI); 4-Carboxyquinoline	Endogenous Metabolite	Metabolic Disease
NSC 13138 is an endogenous metabolite.

HY-B0124

Zonisamide AD 810; CI 912	Carbonic Anhydrase Apoptosis	Neurological Disease
Zonisamide (AD 810) is an orally active carbonic anhydrase inhibitor, with K_is of 35.2 and 20.6 nM for hCA II and hCA V, respectively. Zonisamide exerts neuroprotective effects through anti-apoptosis and upregulating MnSOD levels. Zonisamide also increases the expression of Hrd1, thereby improving cardiac function in AAC rats. Zonisamide can be used in studies of seizure, parkinson’s disease and cardiac hypertrophy .

HY-B0124A

Zonisamide sodium AD 810 sodium; CI 912 sodium	Carbonic Anhydrase Apoptosis	Cardiovascular Disease Neurological Disease
Zonisamide (AD 810) sodium is an orally active carbonic anhydrase inhibitor, with K_is of 35.2 and 20.6 nM for hCA II and hCA V, respectively. Zonisamide sodium exerts neuroprotective effects through anti-apoptosis and upregulating MnSOD levels. Zonisamide sodium also increases the expression of Hrd1, thereby improving cardiac function in AAC rats. Zonisamide sodium can be used in studies of seizure, parkinson’s disease and cardiac hypertrophy .

HY-B0268

Enoxacin AT 2266; CI 919	Bacterial DNA/RNA Synthesis MicroRNA Antibiotic	Infection Cancer
Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC₅₀=126 µg/ml) and topoisomerase IV (IC₅₀=26.5 µg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing .

HY-B0258

Gemfibrozil 1 Publications Verification CI-719	PPAR Cytochrome P450	Cardiovascular Disease Metabolic Disease Cancer
Gemfibrozil is an activator of PPAR-α, used as a lipid-lowering agent; Gemfibrozil is also a nonselective inhibitor of several P450 isoforms, with K_i values for CYP2C9, 2C19, 2C8, and 1A2 of 5.8, 24, 69, and 82 μM, respectively.

HY-100266

Nitromifene

CI628
Estrogen Receptor/ERR Cancer

Nitromifene is an antagonist of estrogen receptor (ER).
HY-119602

Rolziracetam

CI-911
Others Neurological Disease

Rolziracetam is a nootropic agent of the racetam family and improves short-term memory in rats and monkeys .

Nitromifene CI628	Estrogen Receptor/ERR	Cancer
Nitromifene is an antagonist of estrogen receptor (ER).

Rolziracetam CI-911	Others	Neurological Disease
Rolziracetam is a nootropic agent of the racetam family and improves short-term memory in rats and monkeys .

HY-101438

Darbufelone CI-1004
Darbufelone is a dual inhibitor of cellular PGF_2α and LTB₄ production. Darbufelone potently inhibits PGHS-2 (IC₅₀= 0.19 μM) but is much less potent with PGHS-1 (IC₅₀=20 μM).

HY-B0536A

Clinafloxacin hydrochloride AM 1091 hydrochloride; CI 960 hydrochloride; PD127391 hydrochloride	Bacterial Antibiotic	Infection
Clinafloxacin hydrochloride (AM 1091 hydrochloride) is a potent and broad-spectrum fluoroquinolone antibiotic, has inhibitory activity against gram-positive, gram-negative bacterias, and anaerobic pathogens in vitro . Clinafloxacin hydrochloride is against DNA gyrase and topoisomerase IV of S. aureus with IC₅₀ values of 0.92 µg/ml and 1.62 µg/ml, respectively .

HY-100795A

Pirmenol hydrochloride (±)-Pirmenol hydrochloride; CI-845	mAChR Potassium Channel	Cardiovascular Disease
Pirmenol ((±)-Pirmenol) hydrochloride is an orally active antiarrhythmic agent. Pirmenol hydrochloride inhibits I_K.ACh (IC₅₀: 0.1 μM) by blocking mAchR. Pirmenol hydrochloride can be used in the research of cardiovascular disease, such as atrial fibrillation .

HY-123630

Allura Red AC FD&C RED NO. 40; CI 16035	Fluorescent Dye	Others
Allura Red AC, a food colourant, is dark red and water-soluble powder or granules used in various applications, such as in drinks, syrups, sweets and cereals. Allura Red AC has the ability to quench the intrinsic fluorescence of HSA through static quenching .

HY-B0136

Cefdinir 1 Publications Verification FK-482; CI-983	Bacterial Antibiotic	Infection
Cefdinir (FK-482) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, which is proved to be effective for infections caused by several Gram-negative and Gram-positive bacteria. Cefdinir can be used for the research of common bacterial infections of the ear, sinus, throat, and skin .

HY-135460

Milameline

CI-979; RU35926
mAChR Neurological Disease

Milameline is a muscarinic receptor agonist that improves cognition.

HY-103396

Trimetrexate glucuronate CI-898 glucuronate	Antifolate Bacterial	Infection Cancer
Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist. Trimetrexate glucuronate affects DNA and RNA synthesis by inhibiting dihydrofolate reductase and preventing the synthesis of purine nucleotides and thymidylate. Trimetrexate glucuronate has potential antitumour activity and can also be used to inhibit Pneumocystis carinii pneumonia .

HY-B0258R

Gemfibrozil (Standard) 1 Publications Verification CI-719 (Standard)	PPAR Cytochrome P450	Cardiovascular Disease Metabolic Disease Cancer
Gemfibrozil (Standard) is the analytical standard of Gemfibrozil. This product is intended for research and analytical applications. Gemfibrozil is an activator of PPAR-α, used as a lipid-lowering agent; Gemfibrozil is also a nonselective inhibitor of several P450 isoforms, with K_i values for CYP2C9, 2C19, 2C8, and 1A2 of 5.8, 24, 69, and 82 μM, respectively.

HY-D0249

Sunset Yellow FCF 1 Publications Verification Orange Yellow S; Food Yellow 3; CI 15985	Fluorescent Dye	Others
Sunset Yellow FCF (Orange Yellow S) is an orange azo dye with a maximum absorption wavelength of 480 nm. Sunset Yellow FCF can be used in food, cosmetics and pharmaceuticals .

Cat. No.	Product Name	Type

HY-123630

Allura Red AC FD&C RED NO. 40; CI 16035	Dyes
Allura Red AC, a food colourant, is dark red and water-soluble powder or granules used in various applications, such as in drinks, syrups, sweets and cereals. Allura Red AC has the ability to quench the intrinsic fluorescence of HSA through static quenching .

HY-D0249

Sunset Yellow FCF 1 Publications Verification Orange Yellow S; Food Yellow 3; CI 15985	Dyes
Sunset Yellow FCF (Orange Yellow S) is an orange azo dye with a maximum absorption wavelength of 480 nm. Sunset Yellow FCF can be used in food, cosmetics and pharmaceuticals .

HY-124254

C.I. Vat Yellow 2

Dyes

C.I. Vat Yellow 2 is an agent of yellow dye and can also be used for the paper dyeing .
HY-D0293

Acid Blue 1

Xylene Blue; C.I. ACId Blue 1
Dyes

C.I. Acid Blue 1 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
HY-D0983

Trypan red

C.I. 22850
Fluorescent Dyes/Probes

Trypan red is a vital stain.

HY-14536

Methylene Blue

Maximum Cited Publications

13 Publications Verification

Basic Blue 9; CI-52015; Methylthioninium chloride

Chromogenic Assays

Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue is a Tau aggregation inhibitor. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .

HY-D0971

Pyronin Y 3 Publications Verification Pyronine G; C.I. 45005	Fluorescent Dyes/Probes
Pyronin Y (Pyronine G) is a cationic dye that intercalates RNA and has been used to target cell structures including RNA, DNA and organelles. Pyronin Y forms fluorescent complexes with double-stranded nucleic acids (especially RNA) enabling semi-quantitative analysis of cellular RNA. Pyronin Y can be used to identify specific RNA subspecies of ribonuclear proteins complexes in live cells .

HY-129721

Acid Red 26 Ponceau MX; Xylidine ponceau 2R; C.I. 16150	Dyes
Acid Red 26 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-D0256

Direct Black 38 Chlorazol Black E; Ferristatin II disodium; C.I. 30235	Dyes
Direct Black 38 (Chlorazol Black E) is an azo dye. Direct Black 38 induces unscheduled DNA synthesis in liver and micronucleus in bone marrow of rats in vivo .

HY-D0256A

Direct Black 38 free acid Chlorazol Black E free aCId; Ferristatin II; C.I. 30235 free aCId	Dyes
Direct Black 38 free acid is a polysulphonated dye. Direct Black 38 free acid promotes degradation of transferrin receptor-1 in vitro and in vivo .

HY-D0914

Fast Green FCF

FD&C Green No. 3; Food green 3; C.I. 42053

Dyes

Fast Green FCF is a sea green triarylmethane food dye, with absorption maximum ranging from 622 to 626 nm. Fast Green FCF is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF is carcinogenic and acts as a presynaptic locus by inhibiting the release of neurotransmitters in the nervous system .

HY-W110884

*Eriochrome cyanine R indicator (C.I. 43820)*	Dyes
Eriochrome cyanine R indicator (C.I. 43820) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-Y0057

NSC 13138 CInchoninic aCId (6CI,7CI,8CI); 4-Carboxyquinoline	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
NSC 13138 is an endogenous metabolite.

HY-N0822

Shikonin Maximum Cited Publications 31 Publications Verification C.I. 75535; Isoarnebin 4	Quinones Structural Classification Classification of Application Fields Plants Lithospermum erythrorhizon Sieb. et Zucc. Naphthalene Quinones Disease Research Fields Boraginaceae Cancer	Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2
Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC₅₀ of 6.5 μM . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway . Shikonin decreases exosome secretion through the inhibition of glycolysis . Shikonin inhibits AIM2 inflammasome activation .

HY-N1201

Apigenin 20+ Cited Publications 4',5,7-Trihydroxyflavone; Apigenol; C.I. Natural Yellow 1	Structural Classification Classification of Application Fields Flavones Source classification Origanum majorana L. Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Microorganisms Sunscreen Phenols Polyphenols Cosmetic Research Umbelliferae Disease Research Fields Cancer	Autophagy Cytochrome P450 Endogenous Metabolite
Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a K_i of 2 μM.

HY-106702

Fostriecin sodium CI-920	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Phosphatase
Fostriecin (sodium) (compound 1, CI-920) is an antibiotic with a cytotoxic activity. Fostriecin (sodium) is also an inhibitor of protein phosphatase including PP4 (IC₅₀= 3 nM)and PP2 (IC₅₀=1.5 nM) .

HY-N1201R

Apigenin (Standard) 4',5,7-Trihydroxyflavone(Standard); Apigenol(Standard); C.I. Natural Yellow 1 (Standard)	Structural Classification Classification of Application Fields Source classification Origanum majorana L. Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Sunscreen Phenols Cosmetic Research Umbelliferae Disease Research Fields Cancer	Autophagy Cytochrome P450 Endogenous Metabolite
Apigenin (Standard) is the analytical standard of Apigenin. This product is intended for research and analytical applications. Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a K_i of 2 μM.

HY-34431

Purine Purine (6CI,8CI); 3,5,7-Triazaindole; 3H-Imidazo[4,5-d]pyrimidine; 6H-Imidazo[4,5-d]pyrimidine; 7H-Purine; Isopurine; NSC 753; β-Purine	Natural Products Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Purine is an endogenous metabolite.

HY-N0408

Picroside II 1 Publications Verification	Infection Structural Classification Iridoids Neurological Disease Classification of Application Fields Terpenoids Scrophulariaceae Plants Picrorhiza scrophulariiflora Pennell Inflammation/Immunology Disease Research Fields	NF-κB Reactive Oxygen Species Apoptosis Influenza Virus
Picroside II, an iridoid compound extracted from Picrorhiza, exhibits anti-inflammatory and anti-apoptotic activities. picroside II alleviates the inflammatory response in sepsis and enhances immune function by inhibiting the activation of NLRP3 inflammasome and NF-κB pathways . Picroside II is an antioxidant, exhibits a significant neuroprotective effect through reducing ROS production and protects the blood-brain barrier (BBB) after cerebral ischemia-reperfusion (CI/R) injury. Picroside II has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities .

Species:	Human (5)
Tag:	His (5) Avi (4)
Source:	HEK293 (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P700656

	CMG-2/ANTXR2 Protein, Human (HEK293, His) Antxr2; HFS; CI-35; CMG-2; CMG2; ISH; JHF; JHS	Human	HEK293
	The CMG-2/ANTXR2 protein, acting as a receptor for anthrax toxin, binds to collagen IV and laminin, suggesting its role in extracellular matrix adhesion. Gene mutations are associated with juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multiple isoforms have been found. It is expressed in various tissues, including the prostate and endometrium. CMG-2/ANTXR2 Protein, Human (HEK293, His) is the recombinant human-derived CMG-2/ANTXR2 protein, expressed by HEK293 , with C-His labeled tag. The total length of CMG-2/ANTXR2 Protein, Human (HEK293, His) is 285 a.a., with molecular weight of 38-43 kDa.

HY-P700870

	IGF2R Protein, Human (HEK293, His-Avi) CI-MPR; M6PR; MPR 300; IGF-II receptor; M6P/IGF2R; CD222; MPRI	Human	HEK293
	IGF2R Protein orchestrates cellular processes by transporting phosphorylated lysosomal enzymes from the Golgi complex to lysosomes. Lysosomal enzymes, with phosphomannosyl residues, bind to mannose-6-phosphate receptors in the Golgi, forming a complex transported to an acidic prelysosomal compartment. The low pH facilitates complex dissociation, and the receptor is recycled via interaction with the retromer. IGF2R also binds IGF2, positively regulates T-cell coactivation with DPP4, and engages with HA-I and HA-II plasma membrane adapters, showcasing its versatile molecular interactions in intracellular transport. IGF2R Protein, Human (HEK293, His-Avi) is the recombinant human-derived IGF2R protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of IGF2R Protein, Human (HEK293, His-Avi) is 1462 a.a., with molecular weight of 165-200 kDa.

HY-P700869

	IGF2R Protein, Human (Biotinylated, HEK293, His-Avi) CI-MPR; M6PR; MPR 300; IGF-II receptor; M6P/IGF2R; CD222; MPRI	Human	HEK293
	IGF2R Protein orchestrates cellular processes by transporting phosphorylated lysosomal enzymes from the Golgi complex to lysosomes. Lysosomal enzymes, with phosphomannosyl residues, bind to mannose-6-phosphate receptors in the Golgi, forming a complex transported to an acidic prelysosomal compartment. The low pH facilitates complex dissociation, and the receptor is recycled via interaction with the retromer. IGF2R also binds IGF2, positively regulates T-cell coactivation with DPP4, and engages with HA-I and HA-II plasma membrane adapters, showcasing its versatile molecular interactions in intracellular transport. IGF2R Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IGF2R protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of IGF2R Protein, Human (Biotinylated, HEK293, His-Avi) is 1462 a.a., with molecular weight of 165-200 kDa.

HY-P700871

	IGF2R Protein, Human (Domain 1-3, HEK293, His-Avi) CI-MPR; M6PR; MPR 300; IGF-II receptor; M6P/IGF2R; CD222; MPRI	Human	HEK293
	IGF2R Protein orchestrates cellular processes by transporting phosphorylated lysosomal enzymes from the Golgi complex to lysosomes. Lysosomal enzymes, with phosphomannosyl residues, bind to mannose-6-phosphate receptors in the Golgi, forming a complex transported to an acidic prelysosomal compartment. The low pH facilitates complex dissociation, and the receptor is recycled via interaction with the retromer. IGF2R also binds IGF2, positively regulates T-cell coactivation with DPP4, and engages with HA-I and HA-II plasma membrane adapters, showcasing its versatile molecular interactions in intracellular transport. IGF2R Protein, Human (Domain 1-3, HEK293, His-Avi) is the recombinant human-derived IGF2R protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of IGF2R Protein, Human (Domain 1-3, HEK293, His-Avi) is 422 a.a., with molecular weight of 55-65 kDa.

HY-P701061

	IGF2R Protein, Human (Domain 1-7, HEK293, His-Avi) CI-MPR; M6PR; MPR 300; IGF-II receptor; M6P/IGF2R; CD222; MPRI	Human	HEK293
	IGF2R proteins coordinate cellular processes by transporting phosphorylated lysosomal enzymes from the Golgi complex to lysosomes. Lysosomal enzymes with phosphomannosyl residues bind to mannose-6-phosphate receptors in the Golgi apparatus, form complexes, and transport to the acidic prelysosomal compartment. IGF2R Protein, Human (Domain 1-7, HEK293, His-Avi) is the recombinant human-derived IGF2R protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of IGF2R Protein, Human (Domain 1-7, HEK293, His-Avi) is 1033 a.a., with molecular weight of 120-160 kDa.

Cat. No.	Product Name	Chemical Structure

HY-W249257

4-Bromobenzoic acid-d4

4-Bromobenzoic acid-d₄ is the deuterium labeled 4-Bromobenzoic acid-d₄[1].

HY-B0258S

Gemfibrozil-d6
Gemfibrozil-d₆ is the deuterium labeled Gemfibrozil. Gemfibrozil is an activator of PPAR-α, used as a lipid-lowering agent; Gemfibrozil is also a nonselective inhibitor of several P450 isoforms, with Ki values for CYP2C9, 2C19, 2C8, and 1A2 of 5.8, 24, 69, and 82 μM, respectively.

HY-B0308S

Sparfloxacin-d5

Sparfloxacin-d5 is deuterium labeled Sparfloxacin (HY-B0308). Sparfloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity .
HY-Y0225S

p-Fluorophenol-d6

p-Fluorophenol-d₆ is the deuterium labeled p-Fluorophenol[1].

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