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Results for "

Ca2

" in MCE Product Catalog:

By Targets:	CRAC Channel (4) 5-HT Receptor (2) Adenylate Cyclase (1) Adrenergic Receptor (3) Akt (1) Amino Acid Derivatives (1) AMPK (5) Amyloid-β (3) Angiotensin Receptor (3) Antibiotic (5) Apoptosis (31) Arp2/3 Complex (1) Arrestin (1) Autophagy (22) Bacterial (6) Bcl-2 Family (1) Biochemical Assay Reagents (7) Bombesin Receptor (1) Calcium Channel (120) Calmodulin (11) CaMK (14) Cannabinoid Receptor (2) Carbonic Anhydrase (1) Caspase (4) CaSR (4) CCR (6) CDK (1) Chloride Channel (9) Complement System (3) COX (4) CRFR (1) CXCR (1) Cytochrome P450 (1) DNA/RNA Synthesis (2) Dopamine Receptor (3) Drug Metabolite (1) EGFR (4) Endogenous Metabolite (20) ERK (4) Estrogen Receptor/ERR (1) Fluorescent Dye (18) Formyl Peptide Receptor (FPR) (1) Free Fatty Acid Receptor (1) Fungal (6) G protein-coupled Bile Acid Receptor 1 (1) G Protein-coupled Receptor Kinase (GRK) (1) GABA Receptor (8) GHSR (2) Glucokinase (2) GPR35 (1) GPR55 (1) Guanylate Cyclase (1) Histamine Receptor (2) HIV (4) iGluR (3) Influenza Virus (1) Interleukin Related (1) Isotope-Labeled Compounds (3) LPL Receptor (3) mAChR (3) MDM-2/p53 (1) Melanocortin Receptor (1) mGluR (3) Microtubule/Tubulin (1) Mitochondrial Metabolism (4) MMP (1) mTOR (1) Myosin (4) Na+/Ca2+ Exchanger (14) Na+/K+ ATPase (2) nAChR (4) Neuropeptide Y Receptor (3) Neurotensin Receptor (1) NF-κB (3) NOD-like Receptor (NLR) (1) Orexin Receptor (OX Receptor) (2) P2X Receptor (3) Parasite (6) PDGFR (1) Phosphatase (5) Phosphodiesterase (PDE) (8) Phospholipase (10) Piezo Channel (2) PIKfyve (1) PKA (6) PKC (12) Potassium Channel (42) PPAR (1) Prostaglandin Receptor (4) Protease Activated Receptor (PAR) (4) Proteasome (2) Proton Pump (3) Ras (1) Reactive Oxygen Species (9) ROCK (4) ROS Kinase (2) SARS-CoV (2) Sodium Channel (11) Src (1) TGF-beta/Smad (2) Thrombin (1) Thyroid Hormone Receptor (3) TNF Receptor (1) Trk Receptor (1) TRP Channel (21) Wnt (1)
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Biochemical Assay Reagents (7)

Bombesin Receptor (1)

Calcium Channel (120)

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CaSR (4)

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GPR35 (1)

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mAChR (3)

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mGluR (3)

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MMP (1)

mTOR (1)

Myosin (4)

Na+/Ca2+ Exchanger (14)

Na+/K+ ATPase (2)

nAChR (4)

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Neurotensin Receptor (1)

NF-κB (3)

NOD-like Receptor (NLR) (1)

Orexin Receptor (OX Receptor) (2)

P2X Receptor (3)

Parasite (6)

PDGFR (1)

Phosphatase (5)

Phosphodiesterase (PDE) (8)

Phospholipase (10)

Piezo Channel (2)

PIKfyve (1)

PKA (6)

PKC (12)

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PPAR (1)

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Proteasome (2)

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SARS-CoV (2)

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Src (1)

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Wnt (1)

By Research Areas:

Cancer (59)

Cardiovascular Disease (78)

Endocrinology (25)

Infection (19)

Inflammation/Immunology (71)

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Neurological Disease (137)

398

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: CRAC Channel

Cat. No.	Product Name	Target	Research Areas

HY-41076

Ca2+ channel agonist 1	Calcium Channel CDK	Neurological Disease
Ca²⁺ channel agonist 1 is an agonist of *N-type Ca²⁺* channel and an inhibitor of Cdk2, with EC₅₀**s of 14.23 μM and 3.34 μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction.

HY-136460

Calcium ionophore I ETH 1001	Calcium Channel	Others
Calcium ionophore I (ETH 1001) is a selective Ca²⁺ ionophore for biological membranes. Calcium ionophore I can be used in Ca2+-selective microelectrodes that can be used for quantitative intracellular measurements of resting Ca2+-activities and of slowly changing Ca2+-levels.

HY-17404S

Cilnidipine-d7 FRC-8653-d₇	Calcium Channel	Cardiovascular Disease
Cilnidipine-d₇ is deuterium labeled Cilnidipine. Cilnidipine is a long-acting, second-generation dihydropyridine Ca2+-channel blocker on L and N-type Ca2+ channel[1][2][3][4]. Antihypertensive effects[5].

HY-N3729

(-)-Denudatin B Denudatin B	Calcium Channel	Cardiovascular Disease
(-)-Denudatin B is an antiplatelet agent. (-)-Denudatin B relaxed vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated Ca2+ channels. And (-)-Denudatin B has nonspecific antiplatelet action

HY-14657

Dantrolene sodium
F 440
Calcium Channel Metabolic Disease

Dantrolene sodium is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ from the sarcoplasm.

Dantrolene sodium F 440	Calcium Channel	Metabolic Disease
Dantrolene sodium is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ from the sarcoplasm.

HY-B0493

Niflumic acid	Chloride Channel	Inflammation/Immunology
Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.

HY-17403

Manidipine dihydrochloride CV-4093	Calcium Channel	Cardiovascular Disease
Manidipine dihydrochloride (CV-4093) is a dihydropyridine compound and a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM.

HY-P1479

Calmodulin-Dependent Protein Kinase II (290-309)	Autophagy CaMK	Neurological Disease
Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC₅₀ of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II.

HY-P1479A

Calmodulin-Dependent Protein Kinase II(290-309) acetate	Autophagy CaMK	Neurological Disease
Calmodulin-Dependent Protein Kinase II (290-309) acetate is a potent CaMK antagonist with an IC₅₀ of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II.

HY-113308AS

Taurolithocholic acid-d4 sodium	Calcium Channel Endogenous Metabolite	Metabolic Disease
Taurolithocholic acid-d₄ (sodium) is the deuterium labeled Taurolithocholic acid (sodium salt). Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist[1].

HY-B0493S1

Niflumic acid-13C6	Chloride Channel	Inflammation/Immunology
Niflumic acid-¹³C₆ is the ¹³C_{6_{labeled Niflumic acid. Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.}}

HY-113308AS2

Taurolithocholic acid-d4-1 sodium	Calcium Channel Endogenous Metabolite
Taurolithocholic acid-d₄-1 (sodium) is the deuterium labeled Taurolithocholic acid. Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist[1].

HY-113308AS1

Taurolithocholic Acid-d5 sodium salt	Calcium Channel	Metabolic Disease
Taurolithocholic Acid-d₅ (sodium) is the deuterium labeled Taurolithocholic acid sodium salt. Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist[1][2].

HY-14656S

Diltiazem-d3 hydrochloride	Calcium Channel	Cardiovascular Disease
Diltiazem-d₃ (hydrochloride) is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2].

HY-B0493S

Niflumic Acid-d5	Chloride Channel	Inflammation/Immunology
Niflumic Acid-d₅ is the deuterium labeled Niflumic acid. Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis[1][2].

HY-145542S

Isovalerylcarnitine-d9 chloride	Proteasome Endogenous Metabolite	Metabolic Disease
Isovalerylcarnitine-d₉ (chloride) is the deuterium labeled Isovalerylcarnitine (chloride)[1]. Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca2+-dependent proteinase (calpain) of human neutrophils[2].

HY-14656S1

Diltiazem-(acetoxy-d3) (hydrochloride)	Calcium Channel	Cardiovascular Disease
Diltiazem-(acetoxy-d₃) (hydrochloride) is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2].

HY-114400A

TRPV4 agonist-1
TRP Channel Inflammation/Immunology

TRPV4 agonist-1 is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay[1].

TRPV4 agonist-1	TRP Channel	Inflammation/Immunology
TRPV4 agonist-1 is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay[1].

HY-12504

Pyr6 N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridineCarboxamide	TRP Channel	Others
Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).

HY-128678

ORM-10103	Na+/Ca2+ Exchanger	Cardiovascular Disease
ORM-10103 is a specific inhibitor of the *Na+/Ca2+ exchanger (NCX), which decreases the NCX current with estimated IC₅₀s of 55 and 67 nM at -80 and at 20 mV, respectively.*

HY-103319

Calmidazolium chloride R 24571	CaMK Autophagy	Cancer Neurological Disease
Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC₅₀s of 0.15 and 0.35 μM, respectively. Also in anti-cancer research. Calmidazolium binds to CaMK with a K_d of 3 nM.

HY-B0632S

Diltiazem-d6	Calcium Channel	Cardiovascular Disease
Diltiazem-d₆ is the deuterium labeled Diltiazem. Diltiazem is an orally active L-type Ca2+ channel blocker, with antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris[1][2][3].

HY-103308

TRAM-39	Potassium Channel	Neurological Disease
TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IK_Ca) channels. TRAM-39 inhibits KCa3.1 channel with an IC₅₀ value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease.

HY-B1424

Benzthiazide	Carbonic Anhydrase	Cardiovascular Disease Cancer
Benzthiazide is a long-acting diuretic and a hypertension agent. Benzthiazide is an inhibitor of carbonic anhydrase 9 (CA9), with K_is of 8.0, 8.8 and 10 nM for CA9, CA2 and CA1, respectively. Benzthiazide also suppresses proliferation of cancer cells.

HY-116429S

Maresin 1-d5	Reactive Oxygen Species	Inflammation/Immunology
Maresin 1-d₅ is the deuterium labeled Maresin 1. Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity[1][2][3].

HY-119401

CAY10444 BML-241	LPL Receptor	Cancer
CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist. CAY10444 inhibits by 37% S1P-induced increases in Ca²⁺ in HeLa cells expressing S1P3 receptors.

HY-D1608

BODIPY FL Thapsigargin	Calcium Channel	Others
BODIPY FL Thapsigargin is a potent green fluorescent dye. BODIPY FL Thapsigargin inhibits intracellular SERCA-type Ca2+ pumps present in the sarcoplasmic/endoplasmic reticulum. BODIPY FL Thapsigargin used for investigation of thapsigargin binding sites in live cells. Storage: protect from light.

HY-108592

UCL 2077	Potassium Channel	Neurological Disease
UCL 2077 is a selective slow-afterhyperpolarization (sAHP) channel blocker (IC₅₀ = 500 nM in hippocampal neurons in culture), having minimal effects on Ca2+ channels, action potentials, input resistance and the medium after hyperpolarization. UCL 2077 is also a subtype-selective blocker of the epilepsy associated KCNQ channels.

HY-16952A

Bepridil hydrochloride hydrate (±)-Bepridil hydrochloride hydrate; Org 5730 hydrochloride hydrate	Calcium Channel	Cardiovascular Disease
Bepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) is a non-selective, long-acting Ca⁺ channel antagonist and Na⁺, K⁺ channel inhibitor, with antianginal and type I antiarrhythmic effects. Bepridil hydrochloride hydrate also acts as a cardiac *Na⁺/Ca2* + exchange (NCX1)** inhibitor. Bepridil hydrochloride hydrate can be used for the research of cardiovascular disorders.

HY-12962

NMDA-IN-1	iGluR	Neurological Disease
NMDA-IN-1 is a potent and NR2B-selective NMDA antagonist with Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM; no activities on NR2A, NR2C, NR2D, hERG-channel and α1-adrenergic receptor.

HY-101329S

Anthracene-9-carboxylic acid-d9 9-AnthraceneCarboxylic acid-d₉	Chloride Channel	Others
Anthracene-9-carboxylic acid-d₉ is the deuterium labeled Anthracene-9-carboxylic acid[1]. Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells[2].

HY-107855S

DL-Mevalonolactone-d7 (±)-Mevalonolactone-d₇; Mevalolactone-d₇	Endogenous Metabolite	Metabolic Disease
DL-Mevalonolactone-d₇ is the deuterium labeled DL-Mevalonolactone. DL-Mevalonolactone ((±)-Mevalonolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (∆Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2].

HY-D0157

ZnAF-2 ZnAF2; ZnAF 2; 4-[(2-{Bis[(pyridin-2-YL)methyl]amino}ethyl)amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-YL)benzoic acid	Biochemical Assay Reagents	Others
ZnAF-2, 6-iso- is a cell-impermeable compound that acts as a high-affinity Zn2?-specific fluorescent probe (Kd = 2.7 nM). It exhibits low basal fluorescence with an approximately 51-fold increase in fluorescence intensity upon stoichiometric (1:1) binding to Zn2?. Little affinity for Ca2?, Mg2?, Na? or K?.

HY-107855S1

DL-Mevalonolactone-d3 (±)-Mevalonolactone-d₃; Mevalolactone-d₃	Endogenous Metabolite	Metabolic Disease
DL-Mevalonolactone-d₃ is the deuterium labeled DL-Mevalonolactone[1]. DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (?Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[2][3].

HY-12542S

Dantrolene-13C3 F 368-¹³C₃	Isotope-Labeled Compounds	Inflammation/Immunology Neurological Disease
Dantrolene-¹³C₃ is the ¹³C_{3_{labeled Dantrolene. Dantrolene (F368), a muscle relaxant, non-competitively inhibits human erythrocyte glutathione reductase. Ki and IC50 values are 111.6 μM and 52.3 μM, respectively. Dantrolene is a ryanodine receptor antagonist and Ca2+ signaling stabilizer. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome.}}

HY-W181102

NFAT Inhibitor-2	Others	Inflammation/Immunology Neurological Disease Cardiovascular Disease
NFAT Inhibitor-2 is a potent inhibitor of calcineurin NFAT signalling. Calcineurin is a serine/threonine protein phosphatase regulated by Ca2+ and calmodulin. NFAT Inhibitor-2 has the potential for the research of inflammatory disease, an autoimmune disorder, a cardiovascular disease, a neurodegenerative disease, a disease occurring with uncontrolled cell proliferation and/or differentiation, an angiogenesis-related disease, an allergy, anaphylaxis and alopecia (extracted from patent WO2016207212A1, compound 17).

HY-101396

ICA-069673	Potassium Channel	Neurological Disease
ICA-069673 is a *KCNQ2/Q3* potassium channel activator. ICA-069673 demonstrates greater selectivity for *KV7.2/7.3* over KV7.3/KV7.5, with EC₅₀s of 0.69 μM and 14.3 μM, respectively. ICA-069673 inhibits spontaneous phasic and nerve-evoked contractions in guinea pig detrusor smooth muscle (DSM). ICA-069673 also decreases the global intracellular Ca(2+) concentration in DSM cells.

HY-N6789

KT5720	PKA	Cancer Neurological Disease
KT5720 is a potent, cell-permeable, specific, reversible and ATP-competitive PKA inhibitor (IC₅₀=3.3 μM). KT5720 is effective in reversing MDR1-mediated multidrug resistance. KT5720 also reduces the excitability of dorsal root ganglion (DRG) neurons by attenuating Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity and reducing intracellular Ca2 + concentrations. KT5720 can be used in the study of haematological malignancies as well as HCN and DRG neuron-related diseases.

HY-108496S

Sphingosine-1-phosphate-d7 S1P-d₇	Endogenous Metabolite LPL Receptor	Endocrinology
Sphingosine-1-phosphate-d₇ is the deuterium labeled Sphingosine-1-phosphate. Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2].

HY-N0215S14

L-Phenylalanine-15N,d8 (S)-2-Amino-3-phenylpropionic acid-¹⁵N,d₈	Calcium Channel iGluR Endogenous Metabolite	Metabolic Disease
L-Phenylalanine-¹⁵N,d₈ is the deuterium and ¹⁵N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-103309S

ML218-d9	Calcium Channel	Neurological Disease
ML218-d₉ is the deuterium labeled ML218. ML218 is a potent, selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC50s of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, KATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier[1].

HY-P1075

CALP3	Calcium Channel	Cancer Neurological Disease
CALP3, a Ca²⁺-like peptide, is a potent Ca²⁺ channel blocker that activates EF hand motifs of Ca²⁺-binding proteins. CALP3 can functionally mimic increased [Ca²⁺]_i by modulating the activity of Calmodulin (CaM), Ca²⁺ channels and pumps. CALP3 has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia.

HY-P1075A

CALP3 TFA	Calcium Channel	Cancer Neurological Disease
CALP3 TFA, a Ca²⁺-like peptide, is a potent Ca²⁺ channel blocker that activates EF hand motifs of Ca²⁺-binding proteins. CALP3 TFA can functionally mimic increased [Ca²⁺]_i by modulating the activity of Calmodulin (CaM), Ca²⁺ channels and pumps. CALP3 TFA has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia.

HY-U00354

CP-060
Calcium Channel Cardiovascular Disease

CP-060 is a potent Ca²⁺ antagonist, inhibits Ca²⁺ overload and possesses antioxidant and cardioprotective activities.
HY-104056

Fura Red
Fluorescent Dye Others

Fura Red is a Ca²⁺-sensitive fluorescent dye, which decreases in fluorescence with rising [Ca²⁺].
HY-100298

Caldaret
MCC-135
Na+/Ca2+ Exchanger Cardiovascular Disease

Caldaret is an intracellular Ca²⁺ handling modulator that acts through reverse mode Na⁺/Ca²⁺ exchanger inhibition.

CP-060	Calcium Channel	Cardiovascular Disease
CP-060 is a potent *Ca²⁺* antagonist, inhibits Ca²⁺ overload and possesses antioxidant and cardioprotective activities.

Fura Red	Fluorescent Dye	Others
Fura Red is a Ca²⁺-sensitive fluorescent dye, which decreases in fluorescence with rising [Ca²⁺].

Caldaret MCC-135	Na+/Ca2+ Exchanger	Cardiovascular Disease
Caldaret is an intracellular *Ca²⁺* handling modulator that acts through reverse mode Na⁺/Ca²⁺ exchanger inhibition.

HY-126789A

DM-Nitrophen tertasodium	Others	Others
DM-Nitrophen tertasodium is a Ca²⁺ cage. DM-Nitrophen releases Ca²⁺ when cleaved upon illumination with near-ultraviolet light. DM-Nitrophen tertasodium can be used for study of Ca²⁺ signaling.

HY-W018035

DL-Glyceric Acid Glyceric Acid (20% in Water,Ca.2 mol/L)	Endogenous Metabolite	Metabolic Disease
DL-Glyceric Acid is a compound that is secreted excessively in the urine by patients suffering from D-glyceric aciduria.

HY-103317

NAADP
Others Inflammation/Immunology

NAADP, a nucleotide, is a Ca²⁺-mobilizing second messenger. NAADP is essential for initiation of Ca²⁺ signaling.

HY-D1424

Coelenterazine hcp	Fluorescent Dye	Others
Coelenterazine hcp is a Coelenterazine analogue. Coelenterazine hcp shows high sensitivity to Ca²⁺. Coelenterazine hcp is suited for monitoring intracellular Ca²⁺.

HY-126789

DM-Nitrophen
Others Others

DM-Nitrophen is a Ca²⁺ cage. DM-Nitrophen releases Ca²⁺ when cleaved upon illumination with near-ultraviolet light.

HY-D1636

5-Nitro BAPTA	Fluorescent Dye	Others
5-Nitro BAPTA is a calcium chelator, combinded with 2-Me-substituted TM ( as a fluorescent moiety), can be used to form a red fluorescent probe (CaTM-2 AM), for imaging of cytoplasmic Ca²⁺ in cultured living cells. 5-Nitro BAPTA is a building block used in the synthesis of Ca²⁺ specific chelators, Ca²⁺ buffers, and fluorescent Ca²⁺ indicators.

HY-101685

Iganidipine
Calcium Channel Cardiovascular Disease

Iganidipine is a Ca²⁺ antagonist.

HY-D1631

Calcium Green-5N AM	Fluorescent Dye	Neurological Disease
Calcium Green-5N AM is a novel *Ca²⁺*-sensitive fluorescent probe. Calcium Green-5N AM shows enhancement in fluorescence intensity on binding Ca²⁺, and can monitor free Ca²⁺ in neurons.

HY-147005

piCRAC-1	CRAC Channel	Cardiovascular Disease
piCRAC-1 is a potent, photoinducible Ca²⁺ release-activated Ca²⁺ (CRAC) channel inhibitor. piCRAC-1 alleviates thrombocytopenia and hemorrhage.

HY-D1024

Coelenterazine h 2-Deoxycoelenterazine; CLZN-h	Biochemical Assay Reagents	Neurological Disease
Coelenterazine h is a derivative of Coelenterazine. Coelenterazine h is more sensitive to Ca²⁺ than is the native complex, thus providing a valuable tool for measuring small changes in Ca²⁺ concentrations.

HY-13764

Tetrandrine NSC-77037; d-Tetrandrine	Calcium Channel Potassium Channel Parasite	Cancer Inflammation/Immunology
Tetrandrine (NSC-77037; d-Tetrandrine) is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca²⁺ current (ICa) and Ca²⁺-activated K⁺ current.

HY-100718

SCH00013	Others	Cardiovascular Disease
SCH00013 is a cardiotonic agent that primarily acts via an increase in myofibrillar Ca++ sensitivity, have a significant Ca(2+)sensitizing effect at pH 7.2 to 7.4.

HY-101455

CDN1163	Calcium Channel	Metabolic Disease
CDN1163 is an allosteric *sarco/endoplasmic reticulum Ca²⁺-ATPase* (SERCA)** activator that improves Ca²⁺ homeostasis. CDN1163 attenuates diabetes and metabolic disorders.

HY-B0596

Taltirelin TA-0910	Thyroid Hormone Receptor	Neurological Disease Endocrinology
Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC₅₀ of 910 nM and EC₅₀ of 36 nM for stimulating an increase in cytosolic Ca²⁺ concentration (Ca²⁺ release).

HY-17404

Cilnidipine FRC-8653	Calcium Channel	Cardiovascular Disease
Cilnidipine is a long-acting, second-generation dihydropyridine *Ca²⁺-channel* blocker on L and N-type Ca²⁺ channel. Antihypertensive effects.

HY-15754

CGP37157	Na+/Ca2+ Exchanger	Cancer Neurological Disease
CGP37157 is a potent, selective inhibitor of *Na⁺/Ca²⁺* exchanger*, inhibiting the Na⁺-induced Ca²⁺-release* from guinea-pig heart mitochondria, with an IC₅₀ of 0.8 μM.

HY-101428

NS-638	Calcium Channel	Neurological Disease
NS-638 is a small nonpeptide molecule with *Ca²⁺*-channel blocking properties. K⁺-stimulated intracellular Ca²⁺-elevation is blocked with an IC₅₀ value of 3.4 μM.

HY-D0121

INDO 1	Fluorescent Dye	Others
INDO 1 is a fluorescent Ca²⁺ indicator, binds specifically to Ca²⁺ while emitting fluorescence, the maximum emission wavelength shifts from 485 nm before binding to 410 nm.

HY-136283

DMNPE-4 AM-caged-calcium	Others	Neurological Disease
DMNPE-4 AM-caged-calcium, photolabile analogues of EGTA, is an extremely effective Ca²⁺ selective cage, with a K_d for Ca²⁺ of 48 nM and 19 nM at pH 7.2 and pH 7.4, respectively. DMNPE-4 AM-caged-calcium has a lower affinity for Ca²⁺ (K_d=~2 nM) after photolysis.

HY-B0596A

Taltirelin acetate TA-0910 acetate	Thyroid Hormone Receptor	Neurological Disease Endocrinology
Taltirelin acetate (TA-0910 acetate) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC₅₀ of 910 nM and EC₅₀ of 36 nM for stimulating an increase in cytosolic Ca²⁺ concentration (Ca²⁺ release).

HY-15515

SEA0400	Na+/Ca2+ Exchanger	Cardiovascular Disease
SEA0400 is a novel and selective inhibitor of the Na⁺-Ca²⁺ exchanger (NCX), inhibiting Na⁺-dependent Ca²⁺ uptake in cultured neurons, astrocytes, and microglia with IC₅₀s of from 5 to 33 nM.

HY-D0121A

INDO 1 pentapotassium	Fluorescent Dye
INDO 1 pentapotassium is a fluorescent Ca²⁺ indicator, binds specifically to Ca²⁺ while emitting fluorescence, the maximum emission wavelength shifts from 485 nm before binding to 410 nm.

HY-113970A

Nebracetam hydrochloride WEB 1881 FU hydrochloride	mAChR	Neurological Disease
Nebracetam hydrochloride, a nootropic M₁-muscarinic agonist, induces a rise of intracellular Ca²⁺ concentration. Nebracetam hydrochloride exhibits an EC₅₀ of 1.59 mM for elevating [Ca²⁺]_i.

HY-135433

MAPTAM
Others Others

MAPTAM is an intracellular Ca²⁺ chelator.

HY-19608

GSK1016790A	TRP Channel Calcium Channel	Metabolic Disease Cardiovascular Disease
GSK1016790A is a potent and selective transient receptor potential vanilloid 4 (TRPV4) channel agonist. GSK1016790A can elicit Ca²⁺ influx and elevate intracellular Ca²⁺ in HEK cells.

HY-100831

YM-58483 BTP2	CRAC Channel	Inflammation/Immunology
YM-58483 (BTP2) is the first selective and potent inhibitor of CRAC channels and subsequent Ca²⁺ signals. YM-584832 is a blocker of store-operated Ca²⁺ entry (SOCE).

HY-100168

BAPTA	Phospholipase	Others
BAPTA is a selective chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA is widely used as an intracellular buffer for investigating the effects of Ca²⁺ release from intracellular stores or influx via Ca²⁺-permeable channels in the plasma membrane. BAPTA can also inhibit phospholipase C activity independently of their role as Ca²⁺ chelators.

HY-110105

NS8593 hydrochloride	Potassium Channel	Neurological Disease
NS8593 hydrochloride is a potent and selective *small conductance Ca²⁺-activated* K⁺ channels (SK channels) inhibitor. NS8593 hydrochloride reversibly inhibits SK3-mediated currents with a K_d value of 77 nM. NS8593 hydrochloride inhibits all the SK1-3** subtypes Ca²⁺-dependently (K_ds of 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca²⁺), and does not affect the Ca²⁺-activated K⁺ channels of intermediate and large conductance (hIK and hBK channels, respectively).

HY-107658

SN 6	Na+/Ca2+ Exchanger	Cardiovascular Disease
SN 6 is a selective *Na⁺/Ca²⁺* exchanger (NCX)** inhibitor, and inhibits ⁴⁵Ca²⁺ uptake by NCX1, NCX2, and NCX3, with IC₅₀s of 2.9, 16, and 8.6 μM, respectively.

HY-10171

NPS-2143 hydrochloride SB-262470A hydrochloride	CaSR	Metabolic Disease
NPS-2143 hydrochloride (SB-262470A hydrochloride), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 hydrochloride (SB-262470A hydrochloride) blocks increases in cytoplasmic Ca²⁺ concentrations (IC₅₀=43 nM) elicited by activating the Ca²⁺ receptor in HEK 293 cells expressing the human Ca²⁺ receptor.

HY-10007

NPS-2143 SB-262470A	CaSR	Metabolic Disease
NPS-2143 (SB-262470A), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca²⁺ concentrations (IC₅₀=43 nM) elicited by activating the Ca²⁺ receptor in HEK 293 cells expressing the human Ca²⁺ receptor.

HY-100168A

BAPTA tetrasodium	Phospholipase	Others
BAPTA tetrasodium is a selective chelator for calcium. BAPTA tetrasodium, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrasodium is widely used as an intracellular buffer for investigating the effects of Ca²⁺ release from intracellular stores or influx via Ca²⁺-permeable channels in the plasma membrane. BAPTA tetrasodium can also inhibit phospholipase C activity independently of their role as Ca²⁺ chelators.

HY-100168B

BAPTA tetrapotassium	Phospholipase	Others
BAPTA tetrapotassium is a selective chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrapotassium is widely used as an intracellular buffer for investigating the effects of Ca²⁺ release from intracellular stores or influx via Ca²⁺-permeable channels in the plasma membrane. BAPTA tetrapotassium can also inhibit phospholipase C activity independently of their role as Ca²⁺ chelators.

HY-A0057

Gabapentin	Calcium Channel	Neurological Disease Cancer
Gabapentin is a potent, orally active *P/Q type Ca²⁺* channel** blocker. Gabapentin inhibits neuronal Ca²⁺ influx and reduction of neurotransmitter release. Gabapentin is a GABA analog that can be used to relieve neuropathic pain.

HY-15293B

JTV-519 hemifumarate K201 hemifumarate	Calcium Channel	Cardiovascular Disease
JTV-519 hemifumarate (K201 hemifumarate) is a Ca²⁺-dependent blocker of sarcoplasmic reticulum Ca²⁺-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties.

HY-A0057A

Gabapentin hydrochloride	Calcium Channel	Neurological Disease Cancer
Gabapentin hydrochloride is a potent, orally active *P/Q type Ca²⁺* channel** blocker. Gabapentin hydrochloride inhibits neuronal Ca²⁺ influx and reduction of neurotransmitter release. Gabapentin hydrochloride is a GABA analog that can be used to relieve neuropathic pain.

HY-B1558

Bifemelane MCI-2016 free base	Calcium Channel	Neurological Disease
Bifemelane is a nootropic compound. Bifemelan causes the first peak by stimulating release from intracellular Ca²⁺ stores and the second by capacitive entry through store–operated Ca²⁺ channels. Bifemelane will be provided as a pharmacological tool for basic studies on astrocytes.

HY-75161

(-)-Menthol	TRP Channel Endogenous Metabolite	Cancer
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca²⁺-permeable nonselective cation channel, to increase [Ca²⁺]_i. Antitumor activity.

HY-100934

SC-9
NCM 119
PKC Endocrinology

SC-9 is a PKC activator in the presence of Ca²⁺.
HY-14656

Diltiazem hydrochloride
CRD-401
Calcium Channel Cardiovascular Disease

Diltiazem hydrochloride is a Ca²⁺ influx inhibitor (slow channel blocker or calcium antagonist).
HY-113308A

Taurolithocholic acid sodium salt
Calcium Channel Endogenous Metabolite Metabolic Disease

Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca²⁺ agonist.

HY-10588

Bay K 8644 (±)-Bay K 8644	Calcium Channel	Neurological Disease Cardiovascular Disease
Bay K 8644 ((±)-Bay K 8644) is a racemate consisting of two isomers (R)-(+)-Bay-K-8644 and (S)-(-)-Bay-K-8644. Bay K 8644 is a *L-type Ca²⁺* channel agonist with an EC₅₀** of 17.3 nM. Bay K 8644 increases Ca²⁺ influx through sarcolemmal Ca²⁺ channels by increasing the open time of the channel. Bay K 8644 has vasoconstrictive effects.

HY-142050

(R)-IDHP	Calcium Channel	Cardiovascular Disease
(R)-IDHP is an isomer of IDHP, a salvia metabolite that exerts vasorelaxant effects by inhibiting Ca²⁺ release and Ca²⁺ inward flow in voltage-dependent and receptor-operated calcium channels in vascular smooth muscle cells. IDHP is used in studies of cardiovascular disease.

HY-15293A

JTV-519 free base K201 free base	Calcium Channel	Cardiovascular Disease
JTV-519 free base (K201 free base) is a Ca²⁺-dependent blocker of sarcoplasmic reticulum Ca²⁺-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties.

HY-75839

Dronedarone Hydrochloride	Potassium Channel Autophagy	Cardiovascular Disease
Dronedarone Hydrochloride is a non-iodinated amiodarone derivative that inhibits Na⁺, K⁺ and *Ca²⁺* currents.

HY-U00026

Semotiadil recemate fumarate	Calcium Channel	Cardiovascular Disease
Semotiadil recemate fumarate is the recemate of Semotiadil fumarate. Semotiadil fumarate is a novel vasoselective Ca²⁺ channel antagonist.

HY-D1702

Mag-Fura-2 tetrapotassium	Fluorescent Dye	Others
Mag-Fura-2 tetrapotassium is a UV excitable rational fluorescent Mg²⁺/Ca²⁺ indicator (Ex=334-360 nm, Em=510 nm). Mag-Fura-2 tetrapotassium can be used for the determination of Mg²⁺ and Ca²⁺ concentrations.

HY-133168

Englerin A	TRP Channel	Cancer
Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC₅₀s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca²⁺ influx and Ca²⁺ cell overload.

HY-P0189

ω-Conotoxin GVIA
Calcium Channel Neurological Disease

ω-Conotoxin GVIA is an inhibitor of the N-type Ca²⁺ channel.

HY-107319

Almitrine mesylate Almitrine bismesylate; Almitrine bismethanesulfonate; Almitrine dimesylate	Potassium Channel	Neurological Disease Cardiovascular Disease
Almitrine mesylate, a peripheral chemoreceptor agonist, inhibits selectively the Ca²⁺-dependent K⁺ channel.

HY-U00212

Aranidipine
MPC1304
Calcium Channel Cardiovascular Disease

Aranidipine (MPC1304) is a Ca²⁺ channel antagonist with potent and long-lasting antihypertensive effects.
HY-103660

18:0 LYSO-PE
Stearoyl lysophosphatidylethanolamine
Others Neurological Disease

18:0 LYSO-PE is an agent that can induce [Ca²⁺]_i increase.

HY-103312

Xestospongin C (-)-Xestospongin C	Calcium Channel Apoptosis	Neurological Disease
Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca²⁺ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca²⁺ release from cerebellar microsomes with an IC₅₀ of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca²⁺ signaling in neuronal and nonneuronal cells.

HY-19721

ABT-639
Calcium Channel Neurological Disease

ABT-639 is a novel, peripherally acting, selective T-type Ca²⁺ channel blocker.
HY-P0189A

ω-Conotoxin GVIA TFA
Calcium Channel Neurological Disease

ω-Conotoxin GVIA TFA is an inhibitor of the N-type Ca²⁺ channel.
HY-101616

ABT-639 hydrochloride
Calcium Channel Neurological Disease

ABT-639 hydrochloride is a novel, peripherally acting, selective T-type Ca²⁺ channel blocker.
HY-101669

TDN345
Calcium Channel Neurological Disease

TDN345 is a Ca²⁺ antagonist, used for the treatment of vascular and senile dementia including Alzheimer's disease.

HY-D1700

Mag-indo-1/AM	Fluorescent Dye	Others
Mag-indo-1/AM is a cell-permeable fluorescent indicator for Mg²⁺ and also for Ca²⁺ (Ex=340-390 nm, Em=410-490 nm). Mag-indo-1/AM can be used to determine intracellular Mg²⁺ and Ca²⁺ concentrations.

HY-136909

SR33805	Calcium Channel	Cardiovascular Disease
SR33805 is a potent Ca²⁺ channel antagonist, with EC₅₀s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 blocks L-type but not T-type Ca²⁺ channels. SR33805 can be used for the research of acute or chronic failing hearts.

HY-N0601

Ginsenoside Rf Panaxoside Rf	Calcium Channel Endogenous Metabolite	Cancer Neurological Disease
Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits *N-type Ca²⁺* channel**.

HY-101693A

Senazodan hydrochloride MCI 154 hydrochloride	Phosphodiesterase (PDE)	Cardiovascular Disease
Senazodan (MCI 154) (hydrochloride), as a Ca²⁺ sensitiser, shows inhibition effect on PDE III.

HY-135897

Urolithin C	Calcium Channel Reactive Oxygen Species Apoptosis Endogenous Metabolite	Metabolic Disease
Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a *L-type Ca²⁺* channel opener and enhances Ca²⁺ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS)** formation.

HY-50694

Senicapoc ICa-17043	Potassium Channel	Others
Senicapoc (ICA-17043) is a potent and selective Gardos channel (Ca²⁺-activated K⁺ channel; KCa3.1) blocker with an IC₅₀ of 11 nM. Senicapoc blocks Ca²⁺-induced rubidium flux from human RBCs with an IC₅₀ value of 11 nM and inhibits RBC dehydration with IC₅₀ of 30 nM.

HY-N10512

Gangliotetraose Gg4	Others	Neurological Disease
Gangliotetraose (Gg4) is a tetrasccharide, exhibits major components including GM1 and its sialylated derivatives. GM1 facilitates efflux of nuclear Ca²⁺ and reduces the level of nuclear Ca²⁺ that characterizes the differentiated neuron. GM1 affects neuronal plasticity and repair mechanisms, as well as neurotrophin release in the brain.

HY-101693

Senazodan
MCI 154
Phosphodiesterase (PDE) Cardiovascular Disease

Senazodan (MCI 154) is a Ca²⁺ sensitiser, and also shows inhibition effect on PDE III.
HY-19025

CV-159
Calmodulin Inflammation/Immunology

CV-159 is a unique dihydropyridine Ca²⁺ antagonist with an anti-calmodulin (CaM) action, and has antiinflammatory activities.

HY-133596

12,14-Dichlorodehydroabietic acid	Potassium Channel GABA Receptor	Neurological Disease
12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca²⁺-activated K⁺ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABA_A antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca²⁺ and stimulates transmitter release.

HY-N4237

Saikogenin D	Prostaglandin Receptor Potassium Channel	Inflammation/Immunology
Saikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of *[Ca²⁺]i* due to Ca²⁺ release from intracellular stores.

HY-B1546

Benzamil Benzylamiloride	Na+/Ca2+ Exchanger Sodium Channel	Neurological Disease
Benzamil (Benzylamiloride), an Amiloride analogue, is a *Na⁺/Ca²⁺* exchanger (NCX) inhibitor (IC₅₀~100 nM). Benzamil also is a non-selective Deg/epithelial sodium channels (ENaC)** blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca²⁺-activated currents, with an IC₅₀ of 1.1 μM.

HY-B1546A

Benzamil hydrochloride Benzylamiloride hydrochloride	Na+/Ca2+ Exchanger Sodium Channel	Neurological Disease
Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na⁺/Ca²⁺ exchanger (NCX) inhibitor (IC₅₀~100 nM). Benzamil hydrochloride also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca²⁺-activated currents, with an IC₅₀ of 1.1 μM.

HY-N4267

Yangambin	Calcium Channel	Infection Cardiovascular Disease
Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca²⁺ influx through voltage-gated Ca²⁺ channels, leading to the reduction in [Ca²⁺]i in vascular smooth muscle cells and consequent peripheral vasodilation. Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC₅₀ of 33.8 μM and for anti-inflammatory activity with an IC₅₀ of 37.4 μM.

HY-145542

Isovalerylcarnitine chloride	Proteasome Endogenous Metabolite	Metabolic Disease
Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca²⁺-dependent proteinase (calpain) of human neutrophils.

HY-101896

Fluo-4 AM
Fluorescent Dye Others

Fluo-4 AM is a?cell-permeable Ca²⁺?indicator. Storage: protect from light.

HY-12323

ISX-9 Isoxazole 9	Calcium Channel	Neurological Disease
ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca²⁺ influx through both voltage-gated Ca²⁺ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs).

HY-P1076

CALP2	Calmodulin	Inflammation/Immunology
CALP2 is a calmodulin (CaM) antagonist ( (K_d of 7.9 µM)) with high affinity for binding to the CaM EF-hand/Ca²⁺-binding site. CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca²⁺ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages.

HY-P3965

16-38-Thymosin β4 (cattle)
Myosin Neurological Disease

16-38-Thymosin β4 (cattle) is a Ca²⁺-independent MLCK activator with high affinity.
HY-103307

FPL64176
Calcium Channel Cardiovascular Disease

FPL64176, a nondihydropyridine compound, is a potent agonist of L-type Ca²⁺ channels with an EC₅₀ value of 16 nM.

HY-147186

5,5'-Difluoro BAPTA	Others	Others
5,5'-Difluoro BAPTA is a difluoro-derivative of BAPTA (HY-100168). 5,5'-Difluoro BAPTA is the most widely used probe for studying cytosolic free *Ca²⁺* by ¹⁹F NMR. 5,5'-Difluoro BAPTA has high selectivity for Ca²⁺. 5,5'-Difluoro BAPTA can inhibit the growth of pollen tube.

HY-103474

Bicuculline methiodide (+)-Bicuculline methiodide; d-Bicuculline methiodide	GABA Receptor	Neurological Disease
Bicuculline methiodide is a potent GABA(A) receptors blocker. Bicuculline methiodide alters membrane properties and firing pattern. Bicuculline methiodide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca²⁺ -activated K⁺ channels. Bicuculline methiodide facilitates burst firing via blocking apamin-sensitive Ca²⁺ -activated K⁺ current.

HY-N1370

Tanshinone IIA sulfonate sodium Sodium Tanshinone IIA sulfonate; Tanshinone IIA sodium sulfonate	CRAC Channel	Cardiovascular Disease Cancer
Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca²⁺ entry (SOCE), and is used to treat cardiovascular disorders.

HY-101897

Fura-2 AM Fura-2 Acetoxymethyl ester	Fluorescent Dye	Others
Fura-2 AM is a high affinity, intracellular, UV light-excitable and ratiometric fluorescent Ca²⁺ indicator. Storage: protect from light.

HY-10388

TTA-Q6
Calcium Channel Neurological Disease

TTA-Q6 is a selective T-type Ca²⁺ channel antagonist, which can be used in the research of neurological disease.

HY-19062

SM-6586	Calcium Channel Na+/Ca2+ Exchanger	Cardiovascular Disease
SM-6586 is a calcium channel antagonist and inhibitor of Na⁺/H⁺ and *Na⁺/Ca²⁺* exchange transport**, potentially for the treatment of cerebrovasular diseases and hypertension.

HY-P1076A

CALP2 TFA	Calmodulin	Inflammation/Immunology
CALP2 TFA is a calmodulin (CaM) antagonist (K_d of 7.9 µM) with high affinity for binding to the CaM EF-hand/Ca²⁺-binding site. CALP2 TFA inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca²⁺ concentrations. CALP2 TFA potently inhibits of adhesion and degranulation. CALP2 TFA is also a strong activator of alveolar macrophages.

HY-12498

GV-58	Calcium Channel	Neurological Disease
GV-58 is a novel N- and *P/Q-type calcium (Ca²⁺)* channel agonist with EC₅₀*s of 7.21 and 8.81 μM, respectively. GV-58 slows the deactivation of channels, resulting in a large increase in presynaptic Ca²⁺* entry during activity. GV-58 can be used in lambert-eaton myasthenic syndrome (LEMS) research.

HY-129088

HUP30	Potassium Channel Calcium Channel	Cardiovascular Disease
HUP30 is a vasodilating agent. HUP30 stimulates soluble guanylyl cyclase, activate K⁺ channels, and blocks extracellular Ca²⁺ influx.

HY-N7594

Senecionine acetate O-Acetylsenecionine	Mitochondrial Metabolism	Others
Senecionine acetate (O-Acetylsenecionine) is a pyrrolizidine alkaloid. Senecionine acetate inhibits the sequestration of Ca²⁺ in extramitochondrial and mitochondrial compartments possibly by inactivating free sulfhydryl groups.

HY-P1079

ω-Agatoxin TK	Calcium Channel	Neurological Disease
ω-Agatoxin TK, a peptidyl toxin of the venom of Agelenopsis aperta, is a potent and selective *P/Q type Ca²⁺* channel** blocker. ω-Agatoxin TK inhibits the high K⁺ depolarisation-induced rise in internal Ca²⁺ in cerebral isolated nerve endings with an IC₅₀ of of 60 nM. ω-Agatoxin TK has no effect on L-type, N-type, or T-type calcium channels.

HY-115745

Calmodulin antagonist-1	Calmodulin	Cardiovascular Disease
Calmodulin antagonist-1 (W-7) is a calmodulin (CaM) antagonist. Calmodulin antagonist-1 inhibits calmodulin-activated Ca²⁺-phosphodiesterase (PDE) (IC₅₀=28 μM). Calmodulin antagonist-1 also inhibits trypsin-treated Ca²⁺-PDE (IC₅₀=375 μM) in a competitive fashion with respect to cyclic GMP and the K_i value is 300 μM.

HY-131948

3-Chlorodiphenylamine	Potassium Channel	Cardiovascular Disease
3-Chlorodiphenylamine is a high affinity *Ca²⁺ sensitizer* of cardiac muscle. 3-Chlorodiphenylamine is based on diphenylamine and binds to the isolated N-domain of cardiac troponin C (cTnC) (K_d=6 µM). 3-Chlorodiphenylamine is an excellent starting scaffold for the development of more potent Ca²⁺-sensitizing compounds due to its small size, and can be used for systolic heart failure research.

HY-W010451

1,2,4-Trihydroxybenzene	Calcium Channel	Cardiovascular Disease
1,2,4-Trihydroxybenzene (Hydroxyhydroquinone), a by-product of coffee bean roasting, increases intracellular Ca²⁺ concentration in rat thymic lymphocytes.

HY-N7063

Nerol	Reactive Oxygen Species Fungal Mitochondrial Metabolism Apoptosis Endogenous Metabolite	Infection
Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca²⁺ and ROS. Antifungal activity.

HY-136395

Cartap
Others Others

Cartap, an organonitrogen insecticide, can cause a marked irreversible Ca²⁺-dependent contracture in both isolated mouse and rabbit phrenic nerve-diaphragms.

HY-15416

NS309	Potassium Channel	Neurological Disease Cardiovascular Disease
NS309 is a potent and selective activator of the Ca²⁺-activated SK/IK potassium channels, but displays no activity at BK channels.

HY-131012

GoSlo-SR-5-69
Potassium Channel Others

GoSlo-SR-5-69 is a potent activator of large conductance Ca²⁺-activated K⁺ (BK) channels, with an EC₅₀ of 251 nM.

HY-120588

BI 639667 CCR1 antagonist 8	CCR	Inflammation/Immunology Endocrinology
BI 639667 (compound 19n), a third azaindazole series compound, is a CCR1 antagonist, with an IC₅₀ of 1.8 nM in Ca²⁺ flux assay.

HY-120597

SAK3	Calcium Channel	Neurological Disease
SAK3 is a potent T-type voltage-gated Ca²⁺ channels (T-VGCCs) enhancer. SAK3 enhances Cav3.1 and Cav3.3 T-type Ca²⁺ channel currents. Acute SAK3 administration improves memory deficits in olfactory-bulbectomized mice. SAK3 inhibits amyloid β plaque formation in APP-KI mice by activating the proteasome activity.

HY-N0252

Catharanthine (+)-3,4-Didehydrocoronaridine	Calcium Channel	Cancer Cardiovascular Disease
Catharanthine is an alkaloid isolated from Catharanthus roseus, inhibits *voltage-operated L-type Ca²⁺* channel**, with anti-cancer and blood pressure-lowering activity.

HY-108465

Pyr3
TRP Channel Others

Pyr3 is a selective inhibitor of transient receptor potential canonical channel 3 (TRPC3), with an IC₅₀ of 700 nM for TRPC3-mediated Ca²⁺ influx.
HY-138620

MCU-i4
Mitochondrial Metabolism Metabolic Disease

MCU-i4 blocks the IP₃-dependent mitochondrial Ca²⁺-uptake, maintaining the gatekeeping role of their target.

HY-D0973

EGTA-AM EGTA Acetoxymethyl ester	Biochemical Assay Reagents	Neurological Disease
EGTA-AM is a membrane permeable form of EGTA, can be passively loaded into cells to generate intracellular EGTA; EGTA-AM is also a Ca²⁺ chelator with slow chelating dynamics.

HY-101360

1-EBIO 1-Ethyl-2-benzimidazolinone	Potassium Channel	Neurological Disease
1-EBIO is an activator of Ca²⁺ sensitive K⁺ channels. 1-EBIO is used to study the role of K⁺ channels in diverse physiological functions.

HY-10388A

TTA-Q6(isomer)
Calcium Channel Others

TTA-Q6(isomer) is an isomer of TTA-Q6. TTA-Q6 is a selective T-type Ca²⁺ channel antagonist.

HY-131041

Ned-K	Calcium Channel	Cardiovascular Disease
Ned-K is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Ned-K is effective at dampening simulated ischaemia and reperfusion (sIR)-induced Ca²⁺ oscillations in cardiomyocytes.

HY-120261

GB-88	Protease Activated Receptor (PAR)	Inflammation/Immunology
GB-88 is an oral, selective non-peptide antagonist of *PAR2, inhibits PAR2* activated Ca²⁺ release with an IC₅₀ of 2 µM.

HY-N2060

Evocarpine	Apoptosis Bacterial	Cancer Infection Inflammation/Immunology
Evocarpine, a quinolone alkaloid that could be isolated from Evodiae fructus, inhibitss Ca²⁺ influx through voltage-dependent calcium channels. Antimycobacterial activity.

HY-P3811

Autocamtide-3
CaMK Neurological Disease

Autocamtide-3, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca²⁺/calmodulin-dependent kinase II) (CaMK) substrate.
HY-146232

F 13714
F 14679
5-HT Receptor Others

F 13714 (F 14679) is a prototypical 5-HT_1A agonist with a pK_i of 10.23. F 13714 induces large Ca²⁺ responses.

HY-136189

UK-59811 hydrochloride	Calcium Channel	Neurological Disease
UK-59811 hydrochloride, a Br-dihydropyridine derivative, is a potent bacterial homotetrameric model voltage-gated Ca²⁺ (Ca_V) channel Ca_VAb inhibitor with an IC₅₀ of 194 nM.

HY-115767

(±)-1,2-Diolein
1,2-Dioleoyl-rac-glycerol
PKC Others

(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) is a PKC activator. (±)-1,2-Diolein increases myotubes Ca²⁺ influx.

HY-N0252A

Catharanthine Tartrate (+)-3,4-Didehydrocoronaridine Tartrate	Calcium Channel	Cancer Cardiovascular Disease
Catharanthine Tartrate is an alkaloid isolated from Catharanthus roseus, inhibits *voltage-operated L-type Ca²⁺* channel**, with anti-cancer and blood pressure-lowering activity.

HY-120691A

GSK205
TRP Channel Metabolic Disease Inflammation/Immunology

GSK205 is a potent, selective TRPV4 antagonist with an IC₅₀ of 4.19 μM for inhibiting TRPV4-mediated Ca²⁺ influx.

HY-121604

(Rac)-MEM 1003	Calcium Channel	Others
(Rac)-MEM 1003 is the racemate of MEM 1003. MEM 1003, a dihydropyridine compound, is a potent L-type *Ca²⁺* channel antagonist and has the potential for Alzheimer’s disease research.

HY-B1726

Phenacaine HoloCaine	Phosphodiesterase (PDE)	Metabolic Disease
Phenacaine (Holocaine) is a local anesthetic. Phenacaine inhibits the specific calmodulin-dependent stimulation of erythrocyte Ca²⁺-ATPase and cyclic nucleotide phosphodiesterases from brain and heart.

HY-114400

TRPV4 agonist-1 free base	TRP Channel	Inflammation/Immunology
TRPV4 agonist-1 free base is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC₅₀ of 60 nM in the hTRPV4 Ca²⁺ assay.

HY-133614

Dihydroisopimaric acid	Potassium Channel	Others
Dihydroisopimaric acid activates large conductance Ca²⁺ activated K⁺ (BK) channels alphabeta1 in the direct measurement of BKalphabeta1 opening under whole-cell voltage clamp.

HY-D0202

Arsenazo III	Fluorescent Dye	Others
Arsenazo III is a dye useful for detection of micromolar concentrations of ionized Ca²⁺. Arsenazo III can be used for determination of thorium, zirconium, uranium and rare earth elements.

HY-N8493

Mycalolide B	Others	Others
Mycalolide-B is a specific inhibitor of actomyosin ATPase isolated from marine sponge. Mycalolide-B inhibits ATP-induced contraction and Mg²⁺-ATPase activity in the absence of Ca²⁺.

HY-117073

ITH12575	Calcium Channel	Neurological Disease
ITH12575, a CGP37157 derivative, is a potent and selective mNCX blocker. ITH12575 reduces Ca²⁺ influx through CALHM1 at low micromolar concentrations.

HY-103306

Ryanodine	Others	Neurological Disease
Ryanodine is a cell permeant ryanodine receptor modulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca²⁺ release depending on its concentrations. Poisonous diterpenoid found in Ryania speciosa.

HY-16639

ML314	Neurotensin Receptor	Neurological Disease Endocrinology
ML314 is a potent molecule agonist of NTR1 (EC₅₀ = 1.9 μM); showed good selectivity against NTR2 and GPR35, but does not stimulate Ca²⁺ mobilization.

HY-P0188

ω-Conotoxin MVIIC	Calcium Channel	Neurological Disease
ω-Conotoxin MVIIC is a N- and P/Q-type Ca²⁺ channel blocker, significantly suppresses the 11-keto-βboswellic acid-mediated inhibition of glutamate release.

HY-108593

BMS-191011 BMS-A	Potassium Channel	Neurological Disease
BMS 191011 (BMS-A) is a potent BK_Ca channel opener (large-conductance Ca²⁺-activated potassium channel). BMS-191011 shows neuroprotective activities in rodent models of stroke.

HY-15124

(S)-(-)-Bay-K-8644
Calcium Channel Cardiovascular Disease

(S)-(-)-Bay-K-8644 is an agonist of L-type Ca²⁺ channel. (S)-(-)-Bay-K-8644 activates Ba²⁺ currents (I_Ba) (EC₅₀=32 nM).
HY-131942

sFTX-3.3
Calcium Channel Neurological Disease

sFTX-3.3 is a Ca²⁺ channel antagonist with IC₅₀s of approximately 0.24 mM and 0.70 mM against P-type and N-type channels.

HY-142087

Beauverolide Ja	Calmodulin Endogenous Metabolite	Neurological Disease
Beauverolide Ja, a cyclotetradepsipeptide, is a potent calmodulin (CaM) inhibitor with a K_d of 0.078 μM and a K_i of 0.39 μM for Ca²⁺-CaM. Beauverolide Ja is a secondary metabolite of Isaria fumosorosea.

HY-P2149

Concanavalin A	Antibiotic Apoptosis	Cancer Infection Inflammation/Immunology
Concanavalin A is a Ca²⁺/Mn 2+-dependent and mannose/glucose-binding plant lectin that can be found in jack bean. Concanavalin A can induce programmed cell death.

HY-108607

PACOCF3 Palmityltrifluoromethylketone	Phospholipase	Inflammation/Immunology
PACOCF3 (Palmityltrifluoromethylketone) is a selective phospholipase A2 inhibitor with an IC₅₀ of 3.8 μM. PACOCF3 alters Ca²⁺ signaling in renal tubular cells.

HY-100402

CFMTI
mGluR Cancer

CFMTI inhibits L-glutamate-induced intracellular Ca²⁺ mobilization in CHO cells expressing human and rat mGluR1a, with IC₅₀s of 2.6 and 2.3 nM, respectively.

HY-100783A

(-)-Bicuculline methochloride l-Bicuculline methochloride	GABA Receptor	Neurological Disease
(-)-Bicuculline methochloride (l-Bicuculline methochloride) is a potent GABA_A receptor antagonist. (-)-Bicuculline methochloride blocks afterhyperpolarizations (AHPs) mediated by Ca²⁺-activated K⁺ channels in various types of neurons.

HY-10167A

Tecalcet Hydrochloride R-568 hydrochloride	CaSR	Others
Tecalcet Hydrochloride (R 568 Hydrochloride), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet Hydrochloride (R 568 Hydrochloride) increases the sensitivity to activation by extracellular Ca²⁺.

HY-N11369

Leiurus Quinquestriatus Venom Deathstalker Venom	Potassium Channel	Neurological Disease
Leiurus Quinquestriatus Venom (Deathstalker Venom) is a scorpion venom that can be obtained from Deathstalker. Leiurus Quinquestriatus Venom can inhibit different kinds of Ca²⁺-dependent K⁺ channels.

HY-101017

Palmitoylcarnitine chloride	Endogenous Metabolite	Cancer Inflammation/Immunology
Palmitoylcarnitine chloride is a fatty acid-derived mitochondrial substrate, and selectively decreases cell survival in colorectal and prostate cancer cells by affecting on pro-inflammatory pathways, Ca²⁺ influx, and DHT-like effects.

HY-P0188A

ω-Conotoxin MVIIC TFA	Calcium Channel	Neurological Disease
ω-Conotoxin MVIIC TFA is a N- and P/Q-type Ca²⁺ channel blocker, significantly suppresses the 11-keto-βboswellic acid-mediated inhibition of glutamate release.

HY-15705

GPR35 agonist 2	GPR35 Arrestin	Metabolic Disease Inflammation/Immunology
GPR35 agonist 2 (compound 11) is a potent agonist of GPR35, with EC₅₀s of 26 and 3.2 nM in the β-arrestin and Ca²⁺ release assay, respectively.

HY-D1501

Fura PE-3 potassium	Fluorescent Dye	Others
Fura PE-3 potassium is a Ca²⁺sensitive fluorophore. Fura PE-3 potassium loads in IPA (intrapulmonary arteries) and MA (mesenteric resistance arteries) for the research of vasoconstriction.

HY-100783

(-)-Bicuculline methobromide l-Bicuculline methobromide	GABA Receptor	Neurological Disease
(-)-Bicuculline methobromide (l-Bicuculline methobromide) is a potent GABA_A receptor antagonist. (-)-Bicuculline methobromide blocks afterhyperpolarizations (AHPs) mediated by Ca²⁺-activated K⁺ channels in various types of neurons.

HY-N6771

Cyclopiazonic acid	Calcium Channel	Others
Cyclopiazonic acid (CPA), a neurotoxic secondary metabolite (SM) made by Aspergillus flavus, is an inhibitor of endoplasmic reticulum calcium ATPase (Ca²⁺ATPase; SERCA) and a potent inducer of cell death in plants.

HY-B0632

Diltiazem	Calcium Channel	Cardiovascular Disease
Diltiazem is an orally active *L-type Ca²⁺* channel** blocker. Diltiazem shows antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris.

HY-P3944

Calmodulin Dependent Protein Kinase Substrate	CaMK	Neurological Disease
Calmodulin Dependent Protein Kinase Substrate is a *Ca²⁺- and calmodulin (CaM)-dependent protein kinase* (CaMK) substrate peptide. Calmodulin Dependent Protein Kinase Substrate is a synthetic peptide substrate for protein kinases.

HY-P3278

Caloxin 2A1	Proton Pump	Metabolic Disease
Caloxin 2A1 is an extracellular *plasma membrane Ca²⁺-ATPase* (PMCA)** peptide inhibitor. Caloxin 2A1 does not affect basal Mg²⁺-ATPase or Na⁺-K⁺-ATPase.

HY-101015A

OBAA	Phospholipase Apoptosis	Inflammation/Immunology
OBAA is a potent phospholipase A2 (PLA2) inhibitor with an IC₅₀ of 70 nM. OBAA blocks Melittin-induced Ca²⁺ influx in Trypanosoma brucei with an IC₅₀ of 0.4 μM.

HY-P0271

Syntide 2	CaMK Autophagy	Neurological Disease
Syntide 2, a *Ca²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII)* substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected.

HY-106844A

(+)-EMD 57033	Others	Cardiovascular Disease
(+)-EMD 57033 is a cardiac troponin C (cTnC) activator, is a dominant Ca²⁺ sensitizer. (+)-EMD 57033 binds the cardiac/slow skeletal troponin C isoform and exerts myocardial contractile promotion function.

HY-P1080

ω-Agatoxin IVA	Calcium Channel	Neurological Disease
ω-Agatoxin IVA is a potent, selective *P/Q type Ca²⁺* (Cav2.1) channel blocker with IC₅₀s of 2 nM and 90 nM for P-type and Q-type Ca²⁺ channels, respectively. ω-Agatoxin IVA (IC₅₀*, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA also blocks the high potassium-induced release of serotonin and norepinephrine. ω-Agatoxin IVA has no effect on L-type or N-type calcium channels.*

HY-136182A

YM-244769	Na+/Ca2+ Exchanger	Neurological Disease Cardiovascular Disease
YM-244769 is a potent, selective and orally active Na⁺/Ca²⁺ exchanger (NCX) inhibitor. YM-244769 preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca²⁺ entry mode), with IC₅₀s of 18 nM and 50 nM, respectively. YM-244769 efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 can also increase urine volume and urinary excretion of electrolytes in mice.

HY-136182

YM-244769 dihydrochloride	Na+/Ca2+ Exchanger	Neurological Disease Cardiovascular Disease
YM-244769 dihydrochloride is a potent, selective and orally active Na⁺/Ca²⁺ exchanger (NCX) inhibitor. YM-244769 dihydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca²⁺ entry mode), with IC₅₀s of 18 nM and 50 nM, respectively. YM-244769 dihydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 dihydrochloride can also increase urine volume and urinary excretion of electrolytes in mice.

HY-108464A

Phenamil methanesulfonate	Sodium Channel TRP Channel	Metabolic Disease Inflammation/Immunology
Phenamil methanesulfonate, an analog of Amiloride (HY-B0285), is a more potent and less reversible epithelial sodium channel (ENaC) blocker with an IC₅₀ of 400 nM. Phenamil methanesulfonate is also a competive inhibitor of TRPP3 and inhibits TRPP3-mediated Ca²⁺ transport with an IC₅₀ of 140 nM in a Ca²⁺ uptake assay. Phenamil methanesulfonate is an intriguing small molecule to promote bone repair by strongly activating BMP signaling pathway. Phenamil methanesulfonate is used for the research of cystic fibrosis lung disease.

HY-107659

YM-244769 hydrochloride	Na+/Ca2+ Exchanger	Neurological Disease Cardiovascular Disease
YM-244769 hydrochloride is a potent, selective and orally active Na⁺/Ca²⁺ exchanger (NCX) inhibitor. YM-244769 hydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca²⁺ entry mode), with IC₅₀s of 18 nM and 50 nM, respectively. YM-244769 hydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 hydrochloride can also increase urine volume and urinary excretion of electrolytes in mice.

HY-116330

Hyperforin	Calcium Channel TRP Channel	Inflammation/Immunology Neurological Disease
Hyperforin is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin modulates Ca²⁺ levels by activating Ca²⁺-conducting non-selective canonical TRPC6 channels. Hyperforin also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model.

HY-N10772

Albanin A	Calcium Channel Calmodulin Adenylate Cyclase	Inflammation/Immunology Neurological Disease
Albanin A, a flavonoid, suppresses glutamate release by decreasing Ca²⁺/calmodulin/adenylate Cyclase 1 (AC1) activation in synaptosomes and exerts neuroprotective effect in vivo. Albanin A has anti-inflflammatory activity.

HY-116429

Maresin 1	Reactive Oxygen Species	Inflammation/Immunology
Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca²⁺] and secretion. Maresin 1 possesses anti-inflammatory activity.

HY-N0252B

Catharanthine Sulfate (+)-3,4-Didehydrocoronaridine Sulfate	Calcium Channel	Cancer Cardiovascular Disease
Catharanthine Sulfate ((+)-3,4-Didehydrocoronaridine Sulfate) is an alkaloid isolated from Madagascar periwinkle, inhibits *voltage-operated L-type Ca²⁺* channel**, with anti-cancer and blood pressure-lowering activities.

HY-P0271A

Syntide 2 TFA	CaMK	Neurological Disease
Syntide 2 (TFA), a *Ca²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII)* substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected.

HY-100779

Rimacalib SMP 114	CaMK Autophagy	Metabolic Disease
Rimacalib (SMP 114) is a Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) inhibitor, with IC₅₀s of ~1 μM for CaMKIIα to ~30 μM for CaMKIIγ.

HY-P3278A

Caloxin 2A1 TFA	Proton Pump	Metabolic Disease
Caloxin 2A1 TFA is an extracellular *plasma membrane Ca²⁺-ATPase* (PMCA)** peptide inhibitor. Caloxin 2A1 TFA does not affect basal Mg²⁺-ATPase or Na⁺-K⁺-ATPase.

HY-P0256

Apamin Apamine	Potassium Channel	Inflammation/Immunology Neurological Disease
Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of *Ca²⁺*-activated K⁺ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity.

HY-137175

TMBIM6 antagonist-1	mTOR	Cancer
TMBIM6 antagonist-1, a potential TMBIM6 antagonist, prevents TMBIM6 binding to mTORC2, decreases mTORC2 activity, and also regulates TMBIM6-leaky Ca²⁺.

HY-126583

Nemadipine-A	Calcium Channel	Cancer
Nemadipine-A is a specific inhibitor of the EGL-19 L-type Ca²⁺ channel. Nemadipine-A, a cell-permeable L-type calcium channel inhibitor, sensitizes TRAIL-resistant cancer cells to this ligand.

HY-B0401A

Tolbutamide sodium	Apoptosis	Metabolic Disease
Tolbutamide sodium is a potent and orally active antidiabetic agent. Tolbutamide sodium induces apoptosis in a Ca²⁺ dependent manner in pancreatic β-cells. Tolbutamide sodium has the potential for the research of non-insulin-dependent diabetes mellitus.

HY-129496

NP-313	Thrombin	Cardiovascular Disease
NP-313 is a potent antithrombotic agent that inhibits platelet aggregation and activation. NP-313 has dual inhibition of thromboxane A 2 synthesis and selective inhibition of SOCC-mediated Ca²⁺ inward flow.

HY-116291

4α-Phorbol 12,13-didecanoate 4αPDD	TRP Channel	Inflammation/Immunology Neurological Disease
4α-Phorbol 12,13-didecanoate (4αPDD) is a TRPV4 agonist with antidipsogenic effects. 4α-Phorbol 12,13-didecanoate promotes Ca²⁺ influx.

HY-P1247

Calcineurin autoinhibitory peptide	Phosphatase	Neurological Disease
Calcineurin autoinhibitory peptide is a selective inhibitor of Ca²⁺/calmodulin-dependent protein phosphatase (calcineurin), with an IC₅₀ of ~10 μM. Calcineurin autoinhibitory peptide could protect neurons from excitatory neuronal death.

HY-135891

AZD2423	CCR	Neurological Disease
AZD2423 is a potent, selective, orally bioavailable, and non-competitive *CCR2* chemokine receptor negative allosteric modulator. AZD2423 has an IC₅₀ of 1.2 nM for CCR2 Ca²⁺ flux ^[1].

HY-P3943

Calmodulin Dependent Protein Kinase Substrate Analog	CaMK	Neurological Disease
Calmodulin Dependent Protein Kinase Substrate Analog is a *Ca²⁺- and calmodulin (CaM)-dependent protein kinase* (CaMK) substrate peptide. Calmodulin Dependent Protein Kinase Substrate Analog is a synthetic peptide substrate for protein kinases.

HY-116330A

Hyperforin dicyclohexylammonium salt Hyperforin DCHA	TRP Channel Calcium Channel	Neurological Disease
Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca²⁺ levels by activating Ca²⁺-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin dicyclohexylammonium salt modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model.

HY-P1080A

ω-Agatoxin IVA TFA	Calcium Channel	Neurological Disease
ω-Agatoxin IVA TFA is a potent, selective *P/Q type Ca²⁺* (Cav2.1) channel blocker with IC₅₀s of 2 nM and 90 nM for P-type and Q-type Ca²⁺ channels, respectively. ω-Agatoxin IVA TFA (IC₅₀*, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA TFA also blocks the high potassium-induced release of serotonin and norepinephrine. ω-Agatoxin IVA TFA has no effect on L-type or N-type calcium channels.*

HY-19408

Pyr10	TRP Channel	Others
Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca²⁺ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC₅₀ of 0.72 μM (IC₅₀ of 13.08 μM for store operated Ca²⁺ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels.

HY-101366

A-61603	Adrenergic Receptor	Cardiovascular Disease
A-61603 is a selective α_1A-adrenergic receptor agonist. A-61603 increases the frequency of spontaneous Ca²⁺ transients in rat ventricular myocytes in vitro.

HY-B0358

Flunarizine	Calcium Channel Sodium Channel Dopamine Receptor	Neurological Disease
Flunarizine is a potent dual *Na⁺/Ca²⁺* channel (T-type) blocker. Flunarizine is a D₂ dopamine** receptor antagonist. Flunarizine shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects.

HY-B0358A

Flunarizine dihydrochloride	Calcium Channel Sodium Channel Dopamine Receptor	Neurological Disease
Flunarizine dihydrochloride is a potent dual *Na⁺/Ca²⁺* channel (T-type) blocker. Flunarizine dihydrochloride is a D₂ dopamine** receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects.

HY-124416

ML604086	CCR	Inflammation/Immunology Endocrinology
ML604086 is a selective CCR8 inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca²⁺ concentrations.

HY-15553A

Mibefradil dihydrochloride Ro 40-5967 dihydrochloride	Calcium Channel	Cardiovascular Disease
Mibefradil dihydrochloride (Ro 40-5967 dihydrochloride) is a calcium channel blocker with moderate selectivity for T-type Ca²⁺ channels (IC₅₀s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively).

HY-N6688

Verruculogen	Potassium Channel Bacterial Antibiotic	Infection
Verruculogen is a toxin produced mainly by Penicillium and Aspergillus spp. and causes severe tremors in affected animals. Verruculogen inhibits Ca²⁺-activated K⁺ channels. Verruculogen is an M phase inhibitor of the mammalian cell cycle.

HY-P1247A

Calcineurin autoinhibitory peptide TFA	Phosphatase	Neurological Disease
Calcineurin autoinhibitory peptide TFA is a selective inhibitor of Ca²⁺/calmodulin-dependent protein phosphatase (calcineurin), with an IC₅₀ of ~10 μM. Calcineurin autoinhibitory peptide TFA could protect neurons from excitatory neuronal death.

HY-121186

Bevantolol hydrochloride	Adrenergic Receptor Calcium Channel	Metabolic Disease Neurological Disease
Bevantolol hydrochloride is a selective β1 and α1-adrenergic receptor antagonist with pK_i values of 7.83, 6.9 in rat cerebral cortex, respectively. Bevantolol hydrochloride is a potent *Ca²⁺* antagonist.

HY-N5123

α-L-Rhamnose	Others	Others
α-L-Rhamnose is a terminal residue of steviol glycosides Dulcoside A and Dulcoside B. α-L-Rhamnose recognizing lectin site of human dermal fibroblasts functions as a signal transducer: modulation of Ca²⁺ fluxes and gene expression.

HY-151452

Cav 3.2 inhibitor 3	Calcium Channel	Neurological Disease
Cav 3.2 inhibitor 3 (Compound 4) is a potent Ca_v3.2 T-type Ca²⁺ channel inhibitor with an IC₅₀ of 0.1534 μM, and has little binding affinity to D₂ receptors.

HY-P0256A

Apamin TFA Apamine TFA	Potassium Channel	Inflammation/Immunology Neurological Disease
Apamin TFA (Apamine TFA) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of *Ca²⁺*-activated K⁺ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity.

HY-P1805

Calmodulin Binding Peptide 1	Calmodulin	Neurological Disease
Calmodulin Binding Peptide 1 is a high affinity (pM) CaM-binding peptide derived from smooth muscle myosin light-chain kinase (MLCK peptide), which strongly inhibits IP3-induced Ca²⁺ release .

HY-150039

CCG-271423	G Protein-coupled Receptor Kinase (GRK)	Cardiovascular Disease
CCG-271423 is a potent and selective GRK5 inhibitor with IC₅₀ values of 0.0021 μM and 44 μM for GRK5 and GRK2, respectively. CCG-271423 inhibits cardiomyocyte contractility and decreases in Ca²⁺ transience.

HY-15553

Mibefradil Ro 40-5967	Calcium Channel	Cardiovascular Disease
Mibefradil (Ro 40-5967) is a calcium channel blocker with moderate selectivity for T-type Ca²⁺ channels displaying IC₅₀s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively.

HY-110153

NS19504	Potassium Channel	Neurological Disease
NS19504 is a Ca²⁺-activated K⁺ channel (BK channel, KCa1.1 channel) activator (EC₅₀=11.0 µM) with relaxing effect on bladder smooth muscle spontaneous phasic contractions.

HY-111208

CCT129957	Phospholipase	Cancer
CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC₅₀ of ~3 μM and a GC₅₀ of 15 μM. CCT129957 inhibits Ca²⁺ release in squamous carcinoma cells at ~15 μM.

HY-N11378

Parabuthus Granulatus Venom Granulated Thick-tailed Venom	Calcium Channel Sodium Channel	Neurological Disease
Parabuthus Granulatus Venom (Granulated Thick-tailed Venom) is a scorpion venom that can be obtained from Granulated Thick-tailed scorpion. Two scorpion toxins from the scorpion Parabuthus granulatus can inhibit voltage-gated *Ca²⁺* and Na⁺ channels.

HY-103316A

Ned 19	Calcium Channel	Cancer
Ned 19 is a selective membrane-permeant non competitive NAADP antagonist and inhibits NAADP-mediated *Ca²⁺* signaling, with an IC₅₀ of 65 nM. Ned 19 strongly inhibits tumor growth and vascularization as well as lung metastases in mice.

HY-P2471

Neurogranin (48-76), mouse	Calmodulin	Neurological Disease
Neurogranin (48-76), mouse is a peptide corresponding to residues 48-76 of Neurogranin. Neurogranin, a calmodulin-binding protein, is exclusively expressed in the post-synapse, and mediates NMDAR driven synaptic plasticity by regulating the calcium-calmodulin (Ca²⁺-CaM) pathway.

HY-P3156

Syringomycin E	Fungal	Infection
Syringomycin E is an antifungal cyclic lipodepsinonapeptide. Syringomycin E exhibits growth inhibition of Saccharomyces cerevisiae through interaction with the plasma membrane. Syringomycin E causes K⁺ efflux, Ca²⁺ influx, and changes in membrane potential, and is related to channel formation.

HY-N0607

Ginsenoside Ro Polysciasaponin P3; Chikusetsusaponin 5; Chikusetsusaponin V	Calcium Channel Prostaglandin Receptor	Cardiovascular Disease Endocrinology
Ginsenoside Ro (Polysciasaponin P3; Chikusetsusaponin 5; Chikusetsusaponin V) exhibits a *Ca²⁺*-antagonistic antiplatelet effect with an IC₅₀ of 155 μM. Ginsenoside Ro reduces the production of *TXA₂* more than it reduces the activities of COX-1 and TXAS.

HY-111014

VK-II-36	Calcium Channel	Cardiovascular Disease
VK-II-36 is a carvedilol analog that suppresses sarcoplasmic reticulum Ca²⁺release but does not block the β-receptor.VK-II-36 inhibits triggered activities evoked by both early and delayed after depolarizations.

HY-131614

TPC2-A1-N	Calcium Channel	Others
TPC2-A1-N is a powerful and Ca²⁺-permeable agonist of two pore channel 2 (TPC2), which plays its role by mimicking the physiological actions of NAADP. TPC2-A1-P reproducibly evokes significant *Ca²⁺* responses from TPC2 (EC₅₀=7.8 μM), and the effect can be blocked by several TPC blockers. TPC2-A1-N can be used to probe different functions of TPC2 channels in intact cells.

HY-N2344

Procyanidin A1 Proanthocyanidin A1	PKC	Inflammation/Immunology
Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca²⁺ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects.

HY-N0219

Bicuculline (+)-Bicuculline; d-Bicuculline	GABA Receptor	Neurological Disease
Bicuculline ((+)-Bicuculline; d-Bicuculline), as a convulsant alkaloid, is a competitive neurotransmitter GABA_A receptor antagonist (IC₅₀=2 μM). Bicuculline also blocks Ca²⁺-activated potassium (SK) channels and subsequently blocks the slow afterhyperpolarization (slow AHP) ^[1].

HY-123071

Box5	Wnt	Cancer
Box5 is a potent Wnt5a antagonist. Box5 inhibits Wnt5a signaling and inhibits Wnt5a-mediated Ca²⁺ release. Box5 inhibits cell migration. Box5 has the potential for the research of melanoma.

HY-147383

NS-8	Potassium Channel	Endocrinology
NS-8, a pyrrole derivative, activates the Ca²⁺-sensitive k⁺-channel. NS-8 can suppress the micturition reflex by decreasing afferent pelvic nerve activity. NS-8 can be used in the research of urinary frequency and incontinence.

HY-15084B

Dizocilpine MK-801	iGluR	Neurological Disease
Dizocilpine (MK-801), a potent anticonvulsant, is a selective and non-competitive NMDA receptor antagonist, with a K_d of 37.2 nM in rat brain membranes. Dizocilpine acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca²⁺ flux.

HY-P0190

Iberiotoxin	Potassium Channel	Cardiovascular Disease
Iberiotoxin is a toxin isolated from Buthus tamulus scorpion venom. Iberiotoxin is a selective high conductance high conductance Ca²⁺-activated K⁺ channel inhibitor with a K_d of ~1 nM. Iberiotoxin does not block other types of voltage-dependent ion channels.

HY-101329

Anthracene-9-carboxylic acid 9-AnthraceneCarboxylic acid	Chloride Channel	Others
Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca²⁺-activated Cl^- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells.

HY-12949

ML204	TRP Channel	Neurological Disease
ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca²⁺ channels.

HY-107855

DL-Mevalonolactone (±)-Mevalonolactone; Mevalolactone	Endogenous Metabolite	Metabolic Disease
DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (∆Ψm), NAD(P)H content and the capacity to retain Ca²⁺ in the brain, besides inducing mitochondrial swelling.

HY-132191

Pradimicin A	Fungal SARS-CoV HIV	Infection
Pradimicin A (PRM-A) is a potent antifungal agent, with an MIC of 4 μg/mL against Candida rugosa. Pradimicin A has antiviral activities against CoV, HIV and other enveloped viruses. Pradimicin A shows aggregation property, and can recognize d-Man in the presence of Ca²⁺ ion.

HY-15415

KB-R7943 mesylate	Na+/Ca2+ Exchanger Autophagy	Cancer
KB-R7943 mesylate is a widely used inhibitor of the reverse *Na⁺/Ca²⁺* exchanger (NCX_rev) with IC₅₀** of 5.7±2.1 µM. KB-R7943 mesylate induces cancer cell death via activating the JNK pathway and blocking autophagic flux.

HY-147377

N-Salicyloyltryptamine	Calcium Channel ERK Potassium Channel Guanylate Cyclase NF-κB	Inflammation/Immunology Neurological Disease
N-Salicyloyltryptamine acts on voltage-dependent Na⁺, Ca²⁺, and K⁺ ion channels inhibitor. N-Salicyloyltryptamine inhibits K⁺ currents with an IC₅₀ value of 34.6 μM (I_to). N-Salicyloyltryptamine also exhibits anticonvulsant, anti-inflammatory, analgesic, and vasorelaxation effect^-.

HY-13433

Thapsigargin	Calcium Channel SARS-CoV Apoptosis	Cancer Infection
Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal *Ca²⁺-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types.*

HY-120528A

GB-110 hydrochloride	Protease Activated Receptor (PAR)	Cancer Inflammation/Immunology
GB-110 hydrochloride is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist. GB-110 hydrochloride selectively induces PAR2-mediated intracellular Ca²⁺ release in HT29 cells with an EC₅₀ of 0.28 μM.

HY-A0082

Diphenidol hydrochloride Difenidol hydrochloride	mAChR Sodium Channel	Neurological Disease
Diphenidol hydrochloride (Difenidol hydrochloride) is a non-selective muscarinic M₁-M₄ receptor antagonist, has anti-arrhythmic activity. Diphenidol hydrochloride is also a potent non-specific blocker of voltage-gated ion channels (Na⁺, K⁺, and Ca²⁺) in neuronal cells.

HY-P1366

des-Gln14-Ghrelin	GHSR	Metabolic Disease
des-Gln14-Ghrelin is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca²⁺]i in CHO-GHSR62 cells, with an EC₅₀ of 2.4 nM.

HY-12949A

ML204 hydrochloride	TRP Channel	Neurological Disease
ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca²⁺ channels.

HY-B1837A

β-Cyfluthrin beta-Cyfluthrin	Calcium Channel	Neurological Disease
β-Cyfluthrin (beta-Cyfluthrin) is a type II synthetic pyrethroid and also an active ingredient of many insecticide products used for pestsin agriculture. β-Cyfluthrin is a neurotoxicant and affects calcium concentration in nervous tissue by inhibiting Ca²⁺ ATPase involved in calcium transport.

HY-103472

FPR-A14	Formyl Peptide Receptor (FPR)	Neurological Disease
FPR-A14 is a potent formyl peptide receptor (FPR) agonist. FPR-A14 is a potent activator of neutrophil Ca²⁺ mobilization and chemotaxis with EC₅₀s of 630 nM and 42 nM, respectively. FPR-A14 induces cell differentiation.

HY-120528

GB-110	Protease Activated Receptor (PAR)	Cancer Inflammation/Immunology
GB-110 is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist. GB-110 selectively induces PAR2-mediated intracellular Ca²⁺ release in HT29 cells with an EC₅₀ of 0.28 μM.

HY-136190

TRPC6-PAM-C20	TRP Channel	Neurological Disease
TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) of TRPC6 channels. TRPC6-PAM-C20 is a potent enhancer of channel activation, enabling low basal concentrations of DAG to induce activation of the ion channel. TRPC6-PAM-C20 induces increases in intracellular Ca²⁺ concentrations ([Ca²⁺]i) in TRPC6-expressing HEK293 cells with an EC₅₀ of 2.37 μM. TRPC6-PAM-C20 can be used as a valuable tool to selectively exaggerate TRPC6-dependent signals.

HY-146268

CaMKIIα-IN-1	CaMK	Neurological Disease
CaMKIIα-IN-1 (Compound 4d) is an orally active Ca²⁺/calmodulin-dependent protein kinase II α (CaMKIIα) inhibitor with a K_D of 219 nM for CaMKIIα WT hub. CaMKIIα-IN-1 has good metabolic stability.

HY-P1366A

des-Gln14-Ghrelin TFA	GHSR	Metabolic Disease
des-Gln14-Ghrelin TFA is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca²⁺]i in CHO-GHSR62 cells, with an EC₅₀ of 2.4 nM.

HY-145385

Coelenteramide	Fluorescent Dye	Others
Coelenteramide is a oxidative product of Coelenterazine (HY-18743). Coelenteramide can form a complex with apoAequorin/Ca²⁺, which is known as blue fluorescent protein (BFP) and shows continuous weak luminescence with Coelenterazine like a luciferase. Coelenteramide can be used as an imaging agent. Storage: protect from light.

HY-100783B

Bicuculline methobromide (+)-Bicuculline methobromide; d-Bicuculline methobromide	GABA Receptor	Neurological Disease
Bicuculline methobromide is a selective GABAA Receptor antagonist with an IC₅₀ value of 3 μM. Bicuculline methobromide induces clonic tonic convulsions in mammals and can also be used to block Ca²⁺ activated potassium channels. Bicuculline methobromide can be used in studies of epilepsy and other related psychiatric disorders.

HY-103320A

Calhex 231 hydrochloride	CaSR	Metabolic Disease
Calhex 231 hydrochloride is a CaSR inhibitor via negative allosteric modulation. Calhex 231 hydrochloride blocks Ca²⁺-induced accumulation of [³H]inositol phosphate with an IC₅₀ of 0.39 μM in HEK293 cells. Calhex 231 hydrochloride has the potential for diabetic cardiomyopathy (DCM) treatment.

HY-100202

TPEN TPEDA	Reactive Oxygen Species Apoptosis Autophagy	Cancer
TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. TPEN has a higher affinity for Zn²⁺, but a lower affinity for Mg²⁺ and Ca²⁺. TPEN induces DNA damage and increases intracellular ROS production. TPEN also inhibits cell proliferation and induces *apoptosis*.

HY-124873

SERCA2a activator 1	Calcium Channel	Cardiovascular Disease
SERCA2a activator 1 (Compound A) is a sarco/endoplasmic reticulum Ca²⁺-dependent ATPase 2a (SERCA2a) activator. SERCA2a activator 1 attenuates phospholamban inhibition and enhances the systolic and diastolic functions of the heart. SERCA2a activator 1 can be used for heart failure.

HY-Y0413

Biacetyl monoxime Diacetyl monoxime; DAM	Na+/K+ ATPase Myosin	Metabolic Disease
Biacetyl monoxime (Diacetyl monoxime), a myosin ATPase inhibitor, is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime is also a well-characterized non-competitive inhibitor of chemical and motile activity of skeletal muscle myosin-II. Biacetyl monoxime induces sarcoplasmic reticulum Ca²⁺ release.

HY-12728

Tautomycin	Phosphatase	Inflammation/Immunology
Tautomycin, an antifungal antibiotic isolated from the bacterium Streptomyces verticillatus, is a potent and specific inhibitor of protein phosphatases 1 and 2A and induces contraction of smooth muscle under Ca²⁺-free conditions, with K_iapp values of 0.16 nM and 0.4 nM for PP1 and PP2A, respectively.

HY-W009724

2-Aminoethyl diphenylborinate 2-APB	Calcium Channel TRP Channel	Others
2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of IP3R. 2-Aminoethyl diphenylborinate also inhibits the *store-operated Ca²⁺* (SOC) channel and activates some TRP** channels (V1, V2 and V3).

HY-D0110A

Fura-2 pentapotassium	Fluorescent Dye	Others
Fura-2 pentapotassium is a scaled fluorescent dye that can be used for intracellular calcium imaging with the K_d value of 140 nM. Fura-2 pentapotassium has an emission wavelength of 510 nm and excitation wavelengths of 340 nm or 380 nm and the ratio of 340/380 fluorescence intensity is proportional to the intracellular Ca²⁺ level.

HY-120514

JNc-440	TRP Channel Potassium Channel	Cardiovascular Disease
JNc-440 is a potent antihypertensive agent. JNc-440 can enhance the interaction of TRPV4 and Ca²⁺-activated potassium channel 3 (KCa2.3) in endothelial cells. JNc-440 can also enhance vasodilation, and exerted antihypertensive effects in mice.

HY-100973A

Adenosine 5′-diphosphoribose sodium ADP ribose sodium	TRP Channel Autophagy	Endocrinology Metabolic Disease
Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD⁺) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca²⁺-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance *autophagy*.

HY-D0861

EGTA	Biochemical Assay Reagents	Inflammation/Immunology
EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (K_d) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca²⁺ over Mg²⁺ (Mg²⁺ K_d 1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages.

HY-107411

Bromoenol lactone (6E)-Bromoenol lactone	Phospholipase	Inflammation/Immunology
Bromoenol lactone ((6E)-Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A₂ (iPLA₂β) with an IC₅₀ value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca²⁺ influx.

HY-147301

Resomelagon AP1189	Melanocortin Receptor	Metabolic Disease Inflammation/Immunology
Resomelagon (AP1189) is a potent, orally active melanocortin receptor (MR) agonist about MC₁ and MC₃. Resomelagon induces ERK1/2 phosphorylation and Ca²⁺ mobilization. Resomelagon has anti-inflammatory activity. Resomelagon can be used for obesity and chronic inflammation research.

HY-N0742

Absinthin	Others	Others
Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor *hTAS2R46, which reduces cytosolic Ca²⁺-rises* induced by histamine by a receptor-specific mechanism mediated by hTAS2R46.

HY-16935

Mavatrep JNJ-39439335	TRP Channel	Neurological Disease
Mavatrep (JNJ-39439335) is an orally active, selective and potent TRPV1 antagonist with high affinity for hTRPV1 channels (K_i=6.5 nM). Mavatrep antagonizes capsaicin-induced Ca²⁺ influx with an IC₅₀ value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain.

HY-D1643

5,5'-Dinitro BAPTA AM	Biochemical Assay Reagents	Others
5,5'-Dinitro BAPTA AM is a membrane-permeant, high-affinity calcium chelator, it can be used for investigation of the role of cytosolic Ca²⁺. 5,5'-Dinitro BAPTA AM can be loaded by incubation into live cells, and is cleaved by cytosolic esterases to liberate the active tetra-carboxylate ligand.

HY-137790

Bicuculline methochloride (+)-Bicuculline methochloride; d-Bicuculline methochloride	GABA Receptor	Neurological Disease
Bicuculline ((+)-Bicuculline; d-Bicuculline) methochloride is a selective GABAA receptor antagonist with an IC₅₀ value of 3 μM. Bicuculline methochloride induces clonic tonic convulsions in mammals and can also be used to block Ca²⁺ activated potassium channels. Bicuculline methochloride can be used in studies of epilepsy and other related psychiatric disorders.

HY-100912

W-7 hydrochloride	Phosphodiesterase (PDE) Myosin Apoptosis Calmodulin	Cancer
W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the *Ca²⁺-calmodulin*-dependent phosphodiesterase and myosin light chain kinase with IC₅₀ values of 28 μM and 51 µM, respectively. W-7 hydrochloride induces apoptosis and has antitumor activity.

HY-100545

BAPTA-AM	Potassium Channel	Cardiovascular Disease
BAPTA-AM is a well-known membrane permeable Ca²⁺ chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC₅₀s of 1.3 μM, 1.45 μM and 1.23 μM, respectively.

HY-A0236A

Aprindine hydrochloride	Potassium Channel	Cardiovascular Disease
Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a?hERG channel blocker with an IC₅₀ of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na⁺/Ca²⁺ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias research research.

HY-D0861A

EGTA tetrasodium	Biochemical Assay Reagents	Inflammation/Immunology
EGTA tetrasodium is a specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (K_d) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca²⁺ over Mg²⁺ (Mg²⁺ K_d 1-10 mM). EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages.

HY-W013857

Lavendustin C	CaMK EGFR Src	Cancer
Lavendustin C is a potent Ca²⁺ calmodulin-dependent kinase II (CaMK II) inhibitor with an IC₅₀ of 0.2 µM. Lavendustin C inhibits EGFR-associated tyrosine kinase (IC₅₀=0.012 µM) and pp60^c-src(+) kinase (IC₅₀=0.5 µM) ^[1].

HY-129851

NTP42	Prostaglandin Receptor	Cardiovascular Disease
NTP42 is a thromboxane A2 (TXA2) receptor antagonist with an IC₅₀ of 3.278 nM for antagonizing T prostanoid receptor (TP)- mediated [Ca²⁺] mobilization following stimulation of cells with the alternative TP agonist U46619. NTP42 can be used for the treatment of pulmonary arterial hypertension (PAH).

HY-N4104

Agaric acid Agaricinic Acid	Mitochondrial Metabolism	Metabolic Disease
Agaric acid (Agaricinic Acid) is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus igniarius. Agaric acid induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Agaric acid promotes efflux of accumulated Ca²⁺, collapse of transmembrane potential, and mitochondrial swelling. Agaric acid is used to regulate lipid metabolism.

HY-P1437A

Neuropeptide S(Mouse) TFA	Neuropeptide Y Receptor
Neuropeptide S(Mouse) TFA is a potent endogenous neuropeptide S receptor (NPSR) agonist (EC₅₀=3 nM). Neuropeptide S(Mouse) TFA induces mobilization of intracellular Ca²⁺. Neuropeptide S(Mouse) TFA increases locomotor activity and wakefulness in mice. Neuropeptide S(Mouse) TFA also reduces anxiety-like behavior in mice.

HY-13103

NS 11021	Potassium Channel	Others
NS 11021 is a potent and specific Ca²⁺-activated big-conductance K⁺ Channels (KCa1.1 channels) activator. NS 11021 at concentrations above 0.3 μM activates KCa1.1 in a concentration-dependent manner by parallelshifting the channel activation curves to more negative potentials.

HY-16690

BTS N-Benzyl-p-toluenesulfonamide; N-Tosylbenzylamine	Myosin	Others
BTS (N-Benzyl-p-toluenesulfonamide) is a potent and selective inhibitor of skeletal muscle myosin II subfragment 1 (S1) ATPase activity, with an IC₅₀s of ~5 µM for actin- and Ca²⁺-stimulated myosin S1 ATPase. BTS specifically inhibits the contraction of fast skeletal muscle fibers.

HY-B1193

Terfenadine (±)-Terfenadine; MDL-991	Potassium Channel Histamine Receptor Na+/Ca2+ Exchanger Caspase Apoptosis	Cancer Inflammation/Immunology Endocrinology
Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC₅₀ of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of *Ca²⁺* homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.

HY-101015

(2E)-OBAA	Phospholipase Apoptosis	Inflammation/Immunology
(2E)-OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC₅₀ of 70 nM. (2E)-OBAA induces apoptosis of HUVEC cells. (2E)-OBAA blocks Melittin-induced Ca²⁺ influx in Trypanosoma brucei, with an IC₅₀ of 0.4 μM.

HY-101379A

8-Bromo-cGMP sodium	Calcium Channel	Neurological Disease Cardiovascular Disease
8-Bromo-cGMP sodium, a membrane-permeable analogue of cGMP, is a PKG (protein kinase G) activator. 8-Bromo-cGMP sodium significantly inhibits *Ca²⁺* macroscopic currents and impairs insulin release stimulated with high K⁺. 8-Bromo-cGMP sodium has antinociceptive effects and results in vasodilator responses.

HY-16489A

Terodiline hydrochloride	mAChR Calcium Channel	Neurological Disease
Terodiline hydrochloride is an M1-selective muscarinic receptor (mAChR) antagonist with K_bs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline hydrochloride also is a *Ca²⁺* blocker. Terodiline hydrochloride acts as a treatment for urinary frequency and urge incontinence.

HY-118630

Vacuolin-1	PIKfyve Autophagy	Cancer
Vacuolin-1 is a potent and cell-permeable lysosomal exocytosis inhibitor. Vacuolin-1 blocks the Ca²⁺-dependent exocytosis of lysosomes and prevents the release of lysosomal content without affecting the process of resealing. vacuolin‐1 is a potent and selective PIKfyve inhibitor and inhibits late‐stage autophagy by impairing lysosomal maturation.

HY-P1250

RFRP-3(human) Neuropeptide VF(124-131)(human)	Neuropeptide Y Receptor	Neurological Disease
RFRP-3 (Neuropeptide VF(124-131))(human), a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca²⁺ mobilization. RFRP-3(human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC₅₀ of 0.7 nM.

HY-109545

Isopropyl unoprostone Unoprostone isopropyl ester; UF-021	Potassium Channel	Others
Isopropyl unoprostone (Unoprostone isopropyl ester), an analogue of a prostaglandin metabolite, is a potent *large conductance Ca²⁺-activated* K⁺ (BK) channels** activator. Isopropyl unoprostone has antiglaucoma effects, lowering intraocular pressure (IOP) by increasing aqueous humour outflow. Isopropyl unoprostone can improve retinal sensitivity and the protection of central retinal sensitivity.

HY-103442

CGP52411 DAPH	EGFR Amyloid-β	Cancer Neurological Disease
CGP52411 (DAPH) is a high selective, potent, orally active and ATP-competitive EGFR inhibitor with an IC₅₀ of 0.3 μM. CGP52411 blocks the toxic influx of Ca²⁺ ions into neuronal cells, and dramatic inhibits and reverses the formation of β-amyloid (Aβ42) fibril aggregates associated with Alzheimer's disease.

HY-114252

Strophanthidin	Na+/K+ ATPase	Cardiovascular Disease
Strophanthidin is a naturally available cardiac glycoside. Strophanthidin 0.1 and 1 nmol/L increases and 1~100 µmol/L inhibits the Na+/K+-ATPase activities, but Strophanthidin 10 and 100 nmol/L does not affect Na+/K+-ATPase activities in cardiac sarcolemmal. Strophanthidin increases both diastolic and systolic intracellular Ca²⁺ concentration.

HY-P1397A

RVD-Hpα TFA	Cannabinoid Receptor
RVD-Hpα TFA is the N-terminally extended form of human hemopressin that acts as a selective CB1 receptor agonist. RVD-Hpα TFA increases intracellular Ca²⁺ levels in cells expressing CB1 receptors in vitro. RVD-Hpα TFA also high affinity CB2 positive allosteric modulator (K_i=50 nM).

HY-135746

OR-1896	Potassium Channel Phosphodiesterase (PDE) Drug Metabolite Apoptosis	Cardiovascular Disease
OR-1896 is an active long-lived metabolite of Levosimendan. OR-1896 is a highly selective phosphodiesterase (PDE) III isoform inhibitor and a powerful vasodilator. OR-1896 can open ATP-sensitive K⁺ channels and has Ca²⁺-sensitizing effect. OR-1896 mitigates cardiomyocyte apoptosis, cardiac remodeling and myocardial inflammation.

HY-19805

STO-609	CaMK AMPK Autophagy	Metabolic Disease
STO-609 is a selective and cell-permeable inhibitor of the Ca²⁺/calmodulin-dependent protein kinase kinase (CaM-KK), with K_i values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively. STO-609 inhibits AMP-activated protein kinase kinase (AMPKK) activity in HeLa cell lysates with an IC₅₀ ~0.02 g/ml.

HY-P1792

Angiotensin II (1-4), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca²⁺ levels. Angiotensin II also acts at the Na⁺/H⁺ exchanger in the proximal tubules of the kidney.

HY-N6778

Paxilline	Potassium Channel Calcium Channel	Neurological Disease
Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline also inhibits the *sarco/endoplasmic reticulum Ca²⁺* ATPase (SERCA) with IC₅₀*s between 5 μM and 50 μM for differing isoforms. Paxilline possesses significant anticonvulsant activity.*

HY-D0716

Fluo-3AM Fluo-3-pentaacetoxymethyl ester	Fluorescent Dye	Others
Fluo-3 AM is a fluorecent Ca²⁺ chelator, with high affinity for calcium. Fluo-3 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence.

HY-147384

CXL-1020	Calcium Channel	Cardiovascular Disease
CXL-1020 is a hydroxylamine-based nitroxyl (HNO) donor. CXL-1020 improves cardiac inotropy/lusitropy and Ca²⁺ cycling in rats with abnormal relaxation. CXL-1020 induces vasorelaxation and improves cardiac function in canine models. CXL-1020 has been used to research systolic heart failure and stable heart failure.

HY-12496

NS-1619	Potassium Channel Apoptosis	Cancer Cardiovascular Disease
NS-1619 is an opener of large conductance Ca²⁺-activated K⁺ (BK) channel. NS-1619 is a highly effective relaxant with an EC₅₀ of about 10 – 30 μM in several smooth muscles of blood vessels and other tissues. NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells.

HY-18723

Yoda 1	Piezo Channel Akt ERK Potassium Channel	Cardiovascular Disease
Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca²⁺ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation.

HY-P1250A

RFRP-3(human) TFA Neuropeptide VF(124-131)(human) TFA	Neuropeptide Y Receptor	Neurological Disease
RFRP-3 (Neuropeptide VF(124-131))(human) TFA, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca²⁺ mobilization. RFRP-3(human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC₅₀ of 0.7 nM.

HY-P1769

Angiotensin II (5-8), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II. Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca²⁺ levels. Angiotensin II also acts at the Na⁺/H⁺ exchanger in the proximal tubules of the kidney.

HY-12542

Dantrolene F 368	Others	Inflammation/Immunology Neurological Disease
Dantrolene (F368), a muscle relaxant, non-competitively inhibits human erythrocyte glutathione reductase. K_i and IC₅₀ values are 111.6 μM and 52.3 μM, respectively. Dantrolene is a ryanodine receptor antagonist and Ca²⁺ signaling stabilizer. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome.

HY-P1792A

Angiotensin II (1-4), human TFA	Angiotensin Receptor	Endocrinology Metabolic Disease
Angiotensin II (1-4), human (TFA) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca²⁺ levels. Angiotensin II also acts at the Na⁺/H⁺ exchanger in the proximal tubules of the kidney.

HY-B1221

Flufenamic acid	COX AMPK Potassium Channel Chloride Channel Calcium Channel Parasite	Inflammation/Immunology
Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and *L-type Ca²⁺* channels, modulating non-selective cation channels (NSC), activating K⁺ channels**. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

HY-125703

Ferutinin	Estrogen Receptor/ERR Apoptosis	Cancer Infection Endocrinology Inflammation/Immunology
Ferutinin, a natural terpenoid compound, is an estrogen receptor ERα agonist and estrogen ERβ-receptor agonist/antagonist with IC₅₀s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca²⁺-ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities.

HY-103370

Talniflumate BA 7602-06	Chloride Channel	Inflammation/Immunology
Talniflumate (BA 7602-06) is the proagent of Niflumic acid (HY-B0493), exerting its activity in the body through conversion to niflumic acid by esterase. Talniflumate is an orally active Ca²⁺-activated Cl^- channel (CaCC) blocker. Talniflumate can be used as an analgesic and anti-inflammatory agent in cystic fibrosis mouse model of distal intestinal obstructive syndrome.

HY-N11324

Bitis Nasicornis Venom Rhinoceros Viper Venom	Others	Metabolic Disease
Bitis Nasicornis Venom (Rhinoceros Viper Venom) is a snake venom that can be obtained from Bitis Nasicornis. Bitis Nasicornis Venom has anticoagulant activity. Bitis Nasicornis Venom also has insulinotropic effect, and can be used for the research of diabetes. Bitis Nasicornis Venom can increase in intracellular Ca²⁺ concentration and hence a contraction of the the isolated aortic strip in rabbit.

HY-N2500

Deoxypodophyllotoxin	Microtubule/Tubulin Apoptosis Autophagy	Infection Cardiovascular Disease
Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from Anthriscus sylvestris. Deoxypodophyllotoxin, targets the microtubule, has a major impact in oncology not only as anti-mitotics but also as potent inhibitors of angiogenesis. Deoxypodophyllotoxin induces cell autophagy and *apoptosis. Deoxypodophyllotoxin evokes increase of intracellular Ca²⁺* concentrations in DRG neurons.

HY-126010

Dooku1	Piezo Channel	Cardiovascular Disease
Dooku1, an analog of Yoda1, is a selective antagonist of the endogenous Piezo1 channel. Dooku1 inhibited 2 μM Yoda1-induced Ca²⁺-entry with IC₅₀ values of 1.3 μM (in HEK 293 cells) and 1.5 μM (in HUVECs). Dooku1 inhibits Yoda1-induced relaxation of aorta.

HY-D1498

Mag-Fluo-4 AM	Fluorescent Dye	Others
Mag-Fluo-4 AM is a fluorecent Ca²⁺ chelator, with high affinity for calcium. Mag-Fluo-4 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence.

HY-129440

N-(p-Coumaroyl) Serotonin	PDGFR	Metabolic Disease Inflammation/Immunology
N-(p-Coumaroyl) Serotonin is a polyphenol isolated from the seeds of safflower and has antioxidative, anti-atherogenic and anti-inflammatory properties. N-(p-Coumaroyl) Serotonin inhibits PDGF-induced on phosphorylation of PDGF receptor and Ca²⁺ release from sarcoplasmic reticulum. N-(p-Coumaroyl) Serotonin ameliorates atherosclerosis and distensibility of the aortic wall in vivo and is usually used for the atherosclerosis research.

HY-N2359

Chelerythrine	PKC Bcl-2 Family Apoptosis Autophagy	Cancer Metabolic Disease Inflammation/Immunology
Chelerythrine is a natural alkaloid, acts as a potent and selective Ca²⁺/phospholopid-dependent PKC antagonist, with an IC₅₀ of 0.7 μM. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy.

HY-N6687

Calcimycin A-23187; Antibiotic A-23187	Bacterial Fungal Apoptosis Autophagy Antibiotic	Cancer Infection
Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis.

HY-125836

CCR4 antagonist 2	CCR	Cancer Endocrinology
CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits T_reg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC₅₀ values of Ca²⁺flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively.

HY-16697

CID 16020046	GPR55	Cancer
CID 16020046 is a potent and selective GPR55 antagonist and inhibits GPR55 constitutive activity with an IC₅₀ of 0.15 μM. CID 16020046 inhibits GPR55-mediated Ca²⁺ signaling and GPR55-mediated ERK1/2 phosphorylation. CID 16020046 reduces wound healing in endothelial cells and is involved in the regulation of platelet function.

HY-151451

Cav 3.2 inhibitor 2	Calcium Channel	Neurological Disease
Cav 3.2 inhibitor 2 is a Ca_v3.2 T-type Ca²⁺ channels inhibitor with an IC₅₀ of 0.09339 μM under -80mV holding potential. Cav 3.2 inhibitor 2 potently suppresses T-channel-dependent somatic and visceral pain in mice. Cav 3.2 inhibitor 2 can be used for the research of intractable pain.

HY-14350

AC-55541	Protease Activated Receptor (PAR)	Others
AC-55541 is a highly selective protease-activated receptor 2 (PAR2) agonist (pEC₅₀=6.7), displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. AC-55541 has pEC₅₀ values of 5.9 and 6.6 in PI hydrolysis assays and Ca²⁺ mobilization assays and exhibits pronociceptive activity in vivo.

HY-103277

BIM 23042	Bombesin Receptor	Metabolic Disease Neurological Disease
BIM 23042, a certain somatostatin (SS) octapeptide analogue, is a selective neuropeptide neuromedin B receptor (NMB-R, BB1) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin B (HY-P0241), ICI 216140 and DPDM-bombesin ethylamide-induced Ca²⁺ release.

HY-138990

GK563	Phospholipase Apoptosis	Inflammation/Immunology
GK563 is a selective Ca²⁺-independent phospholipase A₂ (GVIA iPLA₂) inhibitor with an IC₅₀ value of 1 nM. GK563 is 22000 times more active against GVIA iPLA₂ than GIVA cPLA₂. GK563 reduces β-cell apoptosis induced by proinflammatory cytokines, raising the possibility that it can be beneficial in countering autoimmune diseases, such as type 1 diabetes.

HY-145196

RTICBM-189	Cannabinoid Receptor	Neurological Disease
RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB₁) receptor with a pIC₅₀ of 7.54 in Ca²⁺ mobilization assay. RTICBM-189 has pIC₅₀s of 5.29 and 6.25 for hCB₁ and mCB₁, respectively. RTICBM-189 significantly and selectively attenuates the reinstatement of the addictive agent-seeking behavior in rats.

HY-16689

VU 0240551	Potassium Channel	Others
VU 0240551 is a potent neuronal K-Cl cotransporter *KCC2* inhibitor (IC₅₀=560 nM) and is selective versus NKCC1. VU 0240551 also inhibits hERG and L-type Ca²⁺ channels. VU 0240551 attenuates GABA-induced hyperpolarization of P cells, produces a positive shift in the P cell GABA reversal potential and enhances P cell synaptic transmission.

HY-101902

Quin-2AM Quin-2 acetoxymethyl ester	Fluorescent Dye	Others
Quin-2AM is a fluorecent Ca²⁺ chelator, with high affinity for calcium. Quin-2AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence. Storage: protect from light.

HY-146462

Anticancer agent 59	Apoptosis ROS Kinase	Cancer
Anticancer agent 59 (compound 11) has inhibitory activity against kinds of cancer cell lines, especially in A549 with IC₅₀ of 0.2 μM. Anticancer agent 59 induces apoptosis and an increase of Ca²⁺ and ROS in cancer cells. Anticancer agent 59 significantly decreases mitochondrial membrane potential. Anticancer agent 59 can suppress tumor growth in A549 mouse xenograft model.

HY-10341

Fasudil Hydrochloride HA-1077 Hydrochloride; AT-877 Hydrochloride	ROCK Calcium Channel Autophagy PKA PKC HIV	Cancer
Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an K_i of 0.33 μM for ROCK1, IC₅₀s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for *ROCK2* and PKA, PKC, PKG, respectively. Fasudil Hydrochloride is also a potent Ca²⁺ channel antagonist and vasodilator.

HY-115681

(2R/S)-6-PNG 6-Prenylnaringenin; (±)-6-Prenylnaringenin	Calcium Channel	Neurological Disease
(2R/S)-6-PNG (6-Prenylnaringenin) is a potent and reversible Ca_v3.2 T-type Ca²⁺ channels (T-channels) blocker. (2R/S)-6-PNG can penetrate the blood-brain barrier (BBB). (2R/S)-6-PNG suppresses neuropathic and visceral pain in mice.

HY-N6732

K-252a SF2370; Antibiotic K 252a; Antibiotic SF 2370	PKC PKA CaMK Trk Receptor Autophagy Antibiotic	Infection Inflammation/Immunology
K-252a, a staurosporine analog, inhibits protein kinase, with IC₅₀ values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca²⁺/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively. K-252a is a potent inhibitor (IC₅₀ of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene.

HY-10341C

Fasudil dihydrochloride HA-1077 dihydrochloride; AT-877 dihydrochloride	Calcium Channel ROCK PKA PKC Autophagy HIV	Cancer
Fasudil (HA-1077; AT877) dihydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an K_i of 0.33 μM for ROCK1, IC₅₀s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for *ROCK2* and PKA, PKC, PKG, respectively. Fasudil dihydrochloride is also a potent Ca²⁺ channel antagonist and vasodilator.

HY-10805A

Almorexant hydrochloride ACT 078573 hydrochloride	Orexin Receptor (OX Receptor) Calcium Channel Caspase Apoptosis	Cancer Endocrinology Neurological Disease
Almorexant (ACT 078573) hydrochloride is an orally active, potent and competitive dual orexin receptor antagonist, with K_d values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant hydrochloride reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant hydrochloride totally blocked the intracellular *Ca²⁺* signal pathway. Almorexant hydrochloride stimulates caspase-3 activity in AsPC-1 cells and induces *apoptosis*.

HY-15671

GKA50	Glucokinase	Metabolic Disease
GKA50 is a potent glucokinase activator (EC₅₀=33 nM at 5 mM glucose). GKA50 stimulates insulin release from mouse islets of Langerhans. GKA50 is a glucose-like activator of beta-cell metabolism in rodent and human islets and a Ca²⁺-dependent modulator of insulin secretion. GKA50 shows significant glucose lowering in high fat fed female rats.

HY-D1640

5',5-Difluoro BAPTA tetrapotassium	Biochemical Assay Reagents	Others
5,5'-Difluoro BAPTA tetrapotassium is a difluoro-derivative of BAPTA (HY-100168). 5,5'-Difluoro BAPTA tetrapotassium shows large ¹⁹F NMR chemical shifts upon chelating divalent cations. 5,5'-Difluoro BAPTA tetrapotassium has high selectivity for Ca²⁺. 5,5'-Difluoro BAPTA tetrapotassium can inhibit the growth of pollen tube.

HY-131001

DPNB-ABT594	nAChR	Neurological Disease
DPNB-ABT594 is a nitrobenzyl-caged ABT594 (HY-14316A) and activates nAChRs containing the *α4β2* subunits with good selectivity than the α7 subunit. DPNB-ABT594 can be used to map the distribution of nAChRs on neurons of the medial habenula (MHb) and helps to gain a deeper understanding of the nAChR‐mediated Ca²⁺ signalling in the MHb.

HY-10805

Almorexant ACT 078573	Orexin Receptor (OX Receptor) Calcium Channel Caspase Apoptosis	Cancer Endocrinology Neurological Disease
Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with K_d values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular *Ca²⁺* signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces *apoptosis*.

HY-10341A

Fasudil HA-1077; AT877	ROCK Calcium Channel Autophagy PKA PKC	Cancer
Fasudil (HA-1077; AT877) is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an K_i of 0.33 μM for ROCK1, IC₅₀s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for *ROCK2* and PKA, PKC, PKG, respectively. Fasudil is also a potent Ca²⁺ channel antagonist and vasodilator.

HY-P1077

CALP1	mGluR Phosphodiesterase (PDE) Apoptosis Calmodulin	Inflammation/Immunology
CALP1 is a calmodulin (CaM) agonist (K_d of 88 µM) with binding to the CaM EF-hand/Ca²⁺-binding site. CALP1 blocks calcium influx and apoptosis (IC₅₀ of 44.78 µM) through inhibition of calcium channel opening. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity.

HY-101906

DC260126	Free Fatty Acid Receptor Apoptosis	Metabolic Disease
DC260126 is a potent antagonist of GPR40 (FFAR1). DC260126 dose-dependently inhibits GPR40-mediated Ca²⁺ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC₅₀: 6.28, 5.96, 7.07, 4.58 μM, respectively). DC260126 could protect MIN6 β cells from palmitate-induced ER stress and *apoptosis*.

HY-15671A

GKA50 quarterhydrate	Glucokinase	Metabolic Disease
GKA50 quarterhydrate is a potent glucokinase activator (EC₅₀=33 nM at 5 mM glucose) and stimulates insulin release from mouse islets of Langerhans. GKA50 quarterhydrate is a glucose-like activator of beta-cell metabolism in rodent and human islets and a Ca²⁺-dependent modulator of insulin secretion. GKA50 quarterhydrate shows significant glucose lowering in high fat fed female rats.

HY-12596

JNJ-26489112	Calcium Channel Sodium Channel Potassium Channel	Neurological Disease
JNJ-26489112, a CNS-active agent, exhibits broad-spectrum anticonvulsant activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures. JNJ-26489112 inhibits voltage-gated Na⁺ channels and N-type Ca²⁺ channels, and is effective as a K⁺ channel opener. JNJ-26489112 has very weak inhibition of CA-II (IC₅₀=35 μM) and CA-I (18 μM).

HY-107678

SEN12333 WAY-317538	nAChR	Neurological Disease
SEN 12333 (WAY-317538) is a potent, selective and orally active α7 nAChR agonist. SEN12333 displays high affinity for the rat α7 nAChRs expressed in GH4C1 cells (K_>i=260 nM) and acts as full agonist in functional Ca²⁺ flux studies (EC₅₀=1.6 μM). SEN 12333 is used for AD and schizophrenia research.

HY-P3316

OSK-1	Potassium Channel	Inflammation/Immunology Neurological Disease
OSK-1 is a potent K_v channel blocker with IC₅₀s of of 0.6 nM, 5.4 nM, 0.014 nM for K_v1.1, K_v1.2 and K_v1.3, respectively. OSK1 is a moderate blocker of Ca²⁺-activated K_Ca3.1 channel with an IC₅₀ of 225 nM. OSK-1 belongs to α-KTx3 toxins and is used as a immunosuppressive agent.

HY-P1077A

CALP1 TFA	mGluR Phosphodiesterase (PDE) Apoptosis Calmodulin	Inflammation/Immunology
CALP1 TFA is a calmodulin (CaM) agonist (K_d of 88 µM) with binding to the CaM EF-hand/Ca²⁺-binding site. CALP1 TFA blocks calcium influx and apoptosis (IC₅₀ of 44.78 µM) through inhibition of calcium channel opening. CALP1 TFA blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 TFA activates CaM-dependent phosphodiesterase activity.

HY-100560

Abscisic acid (S)-(+)-Abscisic acid; ABA	Endogenous Metabolite Proton Pump	Metabolic Disease
Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H⁺-ATPase) and leads to the plasma membrane depolarization in a Ca²⁺-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome.

HY-B1221S1

Flufenamic acid-13C6	Isotope-Labeled Compounds COX AMPK Potassium Channel Chloride Channel Calcium Channel Parasite	Inflammation/Immunology
Flufenamic acid-¹³C₆ is the ¹³C₆ labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca²⁺ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

HY-108599

DCP-LA FR236924	PKC CaMK Phosphatase Apoptosis	Neurological Disease
DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca(²⁺)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis.

HY-N0081

(±)-Praeruptorin A	Calcium Channel	Infection
(±)-Praeruptorin A is the di-esterified product of cis-khellactone (CKL) and the major active ingredient in Peucedani Radix which consists of the dried roots of Peucedanum praeruptorumDunn (Apiaceae). (±)-Praeruptorin A has been widely employed as one of the famous traditional Chinese medicines (TCMs) for the treatment of cough with thick sputum and dyspnea, nonproductive cough and upper respiratory infections for centuries in China. (±)-Praeruptorin A has dramatically therapeutic effects on hypertension mainly through acting as a *Ca²⁺*-influx blocker.

HY-B1671

(+)-Kavain	GABA Receptor Sodium Channel Calcium Channel	Metabolic Disease Neurological Disease
(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na⁺ and Ca²⁺ channels. (+)-Kavain is shown to bind at the α4β2δ GABA_A receptor and potentiate GABA efficacy. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied.

HY-136409

N-Decanoyl-L-homoserine lactone C10-HSL	Bacterial Reactive Oxygen Species	Infection
N-decanoyl-L-homoserine lactone (C10-HSL) is a N-acyl-homoserine lactone (AHL) N-decanoyl-L-homoserine lactone can inhibit primary root growth in Arabidopsis. N-decanoyl-L-homoserine lactone triggers a transient and immediate increase in the concentrations of cytosolic free Ca²⁺ and reactive oxygen species (ROS), increases the activity of mitogen-activated protein kinase 6 (MPK6), and induces nitric oxide (NO) production in Arabidopsis roots.

HY-N6687B

Calcimycin hemimagnesium A-23187 hemimagnesium; Antibiotic A-23187 hemimagnesium	Bacterial Fungal Apoptosis Autophagy	Cancer Infection
Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces *apoptosis*.

HY-16992A

W-54011	Complement System Reactive Oxygen Species	Inflammation/Immunology
W-54011 is a potent and orally active non-peptide C5a receptor antagonist. W-54011 inhibits the binding of ¹²⁵I-labeled C5a to human neutrophils with a K_i value of 2.2 nM. W-54011 also inhibits C5a-induced intracellular Ca²⁺ mobilization, chemotaxis, and generation of ROS in human neutrophils with IC₅₀s of 3.1 nM, 2.7 nM, and 1.6 nM, respectively.

HY-N0385

Gomisin J	AMPK Calcium Channel	Metabolic Disease Cardiovascular Disease
Gomisin J is a small molecular weight lignan found in Schisandra chinensis and has been demonstrated to have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca²⁺/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells. gomisin J has potential benefits in treating nonalcoholic fatty liver disease.

HY-N6701

Dihydrocytochalasin B	Arp2/3 Complex	Cancer
Dihydrocytochalasin B (H2CB) is a Cytokinesis inhibitor and changes the morphology of the cells, similar to that of cytochalasin B; does not inhibit glucose transport. Dihydrocytochalasin B (H2CB) disrupts the actin structure and inhibits the ability of growth factors to stimulate DNA synthesis, reversibly blocks initiation of DNA synthesis. Dihydrocytochalasin B (H2CB) inhibits active calcium transport and causes a Ca²⁺increase in the mucosal scrapings.

HY-10341B

Fasudil hydrochloride semihydrate HA-1077 hydrochloride semihydrate; AT877 hydrochloride semihydrate	ROCK Calcium Channel Autophagy HIV PKA PKC	Cancer
Fasudil (HA-1077; AT877) hydrochloride semihydrate is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an K_i of 0.33 μM for ROCK1, IC₅₀s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for *ROCK2* and PKA, PKC, PKG, respectively. Fasudil hydrochloride semihydrate is also a potent Ca²⁺ channel antagonist and vasodilator.

HY-B1221S

Flufenamic acid-d4	Isotope-Labeled Compounds COX AMPK Potassium Channel Chloride Channel Calcium Channel Parasite	Inflammation/Immunology
Flufenamic acid-d₄ is deuterium labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca²⁺ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

HY-N6687A

Calcimycin hemicalcium salt A-23187 hemiCalcium salt; Antibiotic A-23187 hemiCalcium salt	Bacterial Fungal Apoptosis Autophagy Antibiotic	Cancer Infection
Calcimycin hemicalcium salt (A-23187 hemicalcium salt) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces *apoptosis*.

HY-123205

Oxatomide	Histamine Receptor P2X Receptor 5-HT Receptor	Inflammation/Immunology
Oxatomide is a potent and orally active dual H1-histamine receptor and P2X7 receptor antagonist with antihistamine and anti-allergic activity. Oxatomide almost completely blocks the ATP-induced current in human P2X7 receptors (IC₅₀ of 0.95 μM). Oxatomide inhibits ATP-induced Ca²⁺ influx with an IC₅₀ value of 0.43 μM and also inhibits *serotonin*.

HY-N3945

Glaucine O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396	Phosphodiesterase (PDE) Calcium Channel Adrenergic Receptor Dopamine Receptor Influenza Virus	Infection Inflammation/Immunology
Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with K_is of 3.4 µM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a *Ca²⁺* entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities.

HY-P1821

Myelin Basic Protein MHP4-14	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts.

HY-P4160

PDC31 THG113.31; ILGHXDYK	Prostaglandin Receptor	Endocrinology
PDC31 (THG113.31; ILGHXDYK) is an allosteric and non-competitive inhibitor of FP Prostaglandin Receptor. PDC31 is the D-amino acid-based oligopeptide, is used for smooth muscle contractile agent. PDC31 decreases the strength and duration of uterine contractions in vivo, which can be used for research of preterm labor and primary dysmenorrhea (PD). PDC31 also enhances Ca²⁺-dependent large-conductance K⁺-channel in human myometrial cells.

HY-108496

Sphingosine-1-phosphate S1P	Endogenous Metabolite LPL Receptor	Endocrinology
Sphingosine-1-phosphate (S1P) is an agonist of S1P_1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca²⁺ as an extracellular ligand for G protein-coupled receptors. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids.

HY-151547

MRS4719	P2X Receptor	Neurological Disease
MRS4719 is a potent P2X4 receptor antagonist with an IC₅₀ value of 0.503 μM for human P2X4 receptor. MRS4719 can reduce infarct volume and reduce brain atrophy, showing neuroprotective and neuro-rehabilitative activities in ischemic stroke model. MRS4719 also reduces ATP-induced [Ca²⁺]_i influx in primary human monocyte-derived macrophages. MRS4719 can be used to research ischemic stroke.

HY-131040

NLRP3-IN-NBC6	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor (IC₅₀= 574 nM) that acts independently of Ca²⁺. NLRP3-IN-NBC6 inhibits Nigericin (HY-127019)-induced inflammasome activation in THP-1 cells and Imiquimod (HY-B0180)-induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs).

HY-100001

SKF-96365 hydrochloride	TRP Channel CRAC Channel Potassium Channel Autophagy Apoptosis	Cancer Cardiovascular Disease
SKF-96365 hydrochloride is a potent TRP channel blocker and a *store-operated Ca²⁺* entry (SOCE) inhibitor. SKF-96365 hydrochloride significantly inhibits hERG, hKCNQ1/hKCNE1, hKir2.1 and hKv4.3 current, and significantly prolongs the QTc interval in isolated guinea pig hearts. SKF-96365 hydrochloride exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis** in colorectal cancer cells.

HY-120026

KB130015 KB015	Thyroid Hormone Receptor	Neurological Disease
KB130015 (KB015) is an orally active and potent ThRα and ThRβ (Thyroid Hormone Receptor) inhibitor, with IC₅₀ values of 4.5 and 5.1 μM, respectively. KB130015 has antiarrhythmic properties. KB130015 markedly slows the kinetics of inactivation of Na⁺ channels. KB130015 opens large-conductance Ca²⁺-activated K⁺ channels and relaxes vascular smooth muscle.

HY-108608

o-3M3FBS	Others	Others
o-3M3FBS is the negative control of m-3M3FBS. o-3M3FBS inhibits inward and outward currents via mechanisms independent of PLC acting in an antagonistic manner. In contrast, o-3M3FBS also causes an increase in [Ca²⁺]_i in an agonistic manner.

HY-105118A

Zaldaride maleate CGS-9343B; KW 5617	nAChR	Metabolic Disease Inflammation/Immunology Neurological Disease
Zaldaride maleate (CGS-9343B) is a potent, orally active and selective inhibitor of calmodulin. Zaldaride maleate (CGS-9343B) inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC₅₀ of 3.3 nM. Zaldaride maleate (CGS-9343B) prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na⁺, Ca²⁺ and K⁺ currents in PC12 cells and inhibits nAChR.

HY-P1821A

Myelin Basic Protein TFA MHP4-14 TFA	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14) TFA, a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein TFA is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts.

HY-126750

GNF362	Phosphatase	Inflammation/Immunology
GNF362 is a selective, potent, and orally bioavailable inhibitor of inositol trisphosphate 3’ kinase B (Itpkb) with an IC₅₀ of 9 nM. GNF362 also inhibits Itpka and Itpkc with IC₅₀ values of 20 nM and 19 nM, respectively. Inositol trisphosphate 3’ kinase B (Itpkb) is a Ca²⁺-dependent kinase, which phosphorylates the 3’ position of Ins (1,4,5) P3 to generate inositol 1,3,4,5-tetrakisphosphate [Ins (1,3,4,5) P4].

HY-D0989

Rhod-2 AM	Fluorescent Dye	Others
Rhod-2 is a high-affinity visible light excitation wavelength Ca²⁺ fluorescent probe, Rhod-2, AM is an acetyl methyl ester derivative of Rhod-2, which has cell membrane permeability and can easily enter cells with simple culture. Once it enters the cell, it is sheared by its lactesterase to produce Rhod-2 without membrane permeability, which remains in the cell to perform the corresponding physiological functions. Maximum excitation/emission wavelength: 549/578 nm. Storage: protect from light.

HY-P2847

Urocortin II, mouse	CRFR	Endocrinology Metabolic Disease
Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor with K_i values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca²⁺/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow.

HY-133011

nAChR agonist 1	nAChR	Neurological Disease
nAChR agonist 1 is a potent, brain-permeable, and orally efficacious positive allosteric modulator of α7 nicotinic acetylcholine receptor (α7 nAChR). nAChR agonist 1 has the EC₅₀ of 0.32 µM in a Ca²⁺ mobilization assay (PNU-282987-induced, FLIPR based) in human IMR-32 neuroblastoma cells that endogenously express α7 nAChR. nAChR agonist 1 can be develpoped for the treatment of Alzheimer’s disease.

HY-N1584

Halofuginone RU-19110	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel	Cancer Infection Inflammation/Immunology Cardiovascular Disease
Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca²⁺ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.

HY-12927

SX-517	CXCR	Inflammation/Immunology
SX-517 is a dual *CXCR2/1* antagonist, containing boronic acid. SX-517 inhibits CXCL1-induced Ca²⁺ flux (IC₅₀=38 nM), and antagonizes CXCL8-induced [(35)S]GTPγS binding (IC₅₀=60 nM) and *ERK1/2* phosphorylation. SX-517 has significant ability for inflammation suppression, in both humanized polymorphonuclear (PMN) cells and in murine model.

HY-107543

8-CPT-2Me-cAMP sodium	Ras	Others
8-CPT-2Me-cAMP sodium is a selective activator of exchange proteins activated by cAMP (Epac), the cAMP sensitive guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-CPT-2Me-cAMP sodium activates Epac1 (EC₅₀ = 2.2 μM), but not PKA (EC₅₀> 10 μM). 8-CPT-2Me-cAMP sodium stimulates Epac-mediated Ca²⁺ release in pancreatic β-cells in vitro.

HY-P1387

β-Amyloid (1-40) (rat)	Amyloid-β Apoptosis	Neurological Disease
β-Amyloid (1-40) (rat) is a rat form of the amyloid β-peptide, which accumulates as an insoluble extracellular deposit around neurons, giving rise to the senile plaques associated with Alzheimer's disease (AD). β-Amyloid (1-40) (rat) increases ⁴⁵Ca²⁺ influx, induces neurodegeneration in the rat hippocampal neurons of the CA1 subfield. β-Amyloid (1-40) (rat) induces apoptosis. β-Amyloid (1-40) (rat) can be used for the research of Alzheimer's disease.

HY-103309A

ML218 hydrochloride	Calcium Channel	Neurological Disease
ML218 hydrochloride is a potent, selective and orally active *T-type Ca²⁺* channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC₅₀s of 310 nM and 270 nM for Cav3.2 and Cav3.3**, respectively. ML218 hydrochloride inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 hydrochloride has no significant inhibition of L- or N-type calcium channels, K_ATP or hERG potassium channels. ML218 hydrochloride can penetrate the blood-brain barrier.

HY-103309

ML218	Calcium Channel	Neurological Disease
ML218 is a potent, selective and orally active *T-type Ca²⁺* channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC₅₀s of 310 nM and 270 nM for Cav3.2 and Cav3.3**, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, K_ATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier.

HY-145384

ROC-0929	Phospholipase	Inflammation/Immunology
ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A₂ (sPLA₂s) with an IC₅₀ of 80 nM, specially targeting hGX. ROC-0929 inhibits the phosphorylation of *ERK1/2* and p-38. Secreted phospholipases A2 (sPLA2s) are a family of disulfide-rich, Ca²⁺-dependent enzymes that hydrolyze the sn-2 position of glycero-phospholipids to release a fatty acid and a lysophospholipid. ROC-0929 has the potential for researching inflammation related diseases.

HY-P1345

TLQP-21	Complement System	Endocrinology Neurological Disease
TLQP-21, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor 1 (C3aR1) agonist (EC₅₀: mouse TLQP-21=10.3 μM; human TLQP-21=68.8 μM). TLQP-21 activates C3aR1 to induce an increase of intracellular Ca²⁺. TLQP-21 is used for the research in regulation of nociception and other relevant physiologic functions.

HY-146461

Anticancer agent 58	Apoptosis Caspase ROS Kinase	Cancer
Anticancer agent 58 (compound 16) has inhibitory activity against kinds of cancer cell lines, especially in A549 and T24 with IC₅₀s of 0.6 μM and 0.7 μM, respectively. Anticancer agent 58 induces apoptosis by activating caspase 3/8/9 activity, and induces an increase of Ca²⁺ and ROS in cancer cells. Anticancer agent 58 significantly decreases mitochondrial membrane potential. Anticancer agent 58 can suppress tumor growth in T24 mouse xenograft model.

HY-145900

S100A2-p53-IN-1	MDM-2/p53	Cancer
S100A2-p53-IN-1 (compound 51) is a *S100A2-p53* interactions inhibitor. S100A2 is a Ca²⁺ binding protein with implications in cell signaling and is known to be upregulated in pancreatic cancer. S100A2-p53-IN-1 can inhibit the growth of the MiaPaCa-2 pancreatic cancer cell line (GI⁵⁰ of 1.2-3.4 μM).

HY-N1584A

Halofuginone hydrobromide RU-19110 hydrobromide	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel	Cancer Infection Inflammation/Immunology Cardiovascular Disease
Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.

HY-101044

PPADS tetrasodium	P2X Receptor Na+/Ca2+ Exchanger	Neurological Disease
PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC₅₀s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC₅₀~0.9 mM) and recombinant P2Y4 (IC₅₀~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca²⁺ exchanger in guinea pig airway smooth muscle.

HY-N1940

β-Anhydroicaritin	Interleukin Related TNF Receptor MMP	Inflammation/Immunology
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties. β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats. β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca²⁺, and markedly decreases iNOS protein expression.

HY-P1345A

TLQP-21 TFA	Complement System	Endocrinology Neurological Disease
TLQP-21 TFA, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor1 (C3aR1) agonist (EC₅₀: mouse TLQP-21=10.3 μM; human TLQP-21=68.8μM). TLQP-21 TFA activates C3aR1 to induce an increase of intracellular Ca²⁺. TLQP-21 TFA is used for the research in regulation of nociception and other relevant physiologic functions.

HY-N0043

Ginsenoside Rd Gypenoside VIII	NF-κB COX Calcium Channel Cytochrome P450 Endogenous Metabolite	Inflammation/Immunology Cardiovascular Disease Cancer
Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC₅₀ of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of *COX-2* and iNOS mRNA. Ginsenoside Rd also inhibits *Ca²⁺* influx. Ginsenoside Rd inhibits *CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC₅₀*s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.

HY-P1845

PACAP-38 (31-38), human, mouse, rat	ERK EGFR Reactive Oxygen Species Calcium Channel	Neurological Disease
PACAP-38 (31-38), human, mouse, rat is a PAC₁ receptor activator and increases the α-secretase activity. PACAP-38 (31-38), human, mouse, rat elevates cytosolic Ca²⁺, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP-38 (31-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP-38 (31-38), human, mouse, rat can be used for neurotrophic and neuroprotective research.

HY-N0515

Ophiopogonin D	PPAR NF-κB Calcium Channel	Inflammation/Immunology Cardiovascular Disease
Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca²⁺ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years.

HY-P1845A

PACAP-38 (31-38), human, mouse, rat TFA	ERK EGFR Reactive Oxygen Species Calcium Channel	Neurological Disease
PACAP-38 (31-38), human, mouse, rat TFA is a PAC₁ receptor activator and increases the α-secretase activity. PACAP-38 (31-38), human, mouse, rat TFA elevates cytosolic Ca²⁺, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP-38 (31-38), human, mouse, rat TFA demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP-38 (31-38), human, mouse, rat TFA can be used for neurotrophic and neuroprotective research.

HY-15724

Vercirnon GSK-1605786; CCX282-B; Traficet-EN	CCR	Inflammation/Immunology Endocrinology
Vercirnon (GSK1605786A) is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon inhibits CCR9-mediated Ca²⁺ mobilization and chemotaxis on Molt-4 cells with IC₅₀ values of 5.4 and 3.4 nM, respectively. Vercirnon is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC₅₀s>10 µM for all). Vercirnon is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC₅₀ values of 2.8 and 2.6 nM, respectively.

HY-14229

TGR5 Receptor Agonist CCDC	G protein-coupled Bile Acid Receptor 1 Calcium Channel	Metabolic Disease
TGR5 Receptor Agonist (CCDC), a potent Takeda G protein-coupled receptor 5 (TGR5; GPCR19) agonist, shows improved potency in the U2-OS cells and melanophore cells with pEC₅₀s of 6.8 and 7.5, respectively. TGR5 Receptor Agonist can induce peripheral and central hypersensitivity to bladder distension in mice, and increase intracellular *Ca²⁺* concentration. TGR5 Receptor Agonist can also reduces food intake and improves insulin responsiveness, in diet-induced obese mice. TGR5 Receptor Agonist can be used to research diabetes, bladder hypersensitivity and anti-obesity.

HY-15724A

Vercirnon sodium GSK-1605786 sodium; CCX282-B sodium; Traficet-EN sodium	CCR	Inflammation/Immunology Endocrinology
Vercirnon (GSK1605786A) sodium is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon sodium inhibits CCR9-mediated Ca²⁺ mobilization and chemotaxis on Molt-4 cells with IC₅₀ values of 5.4 and 3.4 nM, respectively. Vercirnon sodium is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC₅₀s>10 µM for all). Vercirnon sodium is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC₅₀ values of 2.8 and 2.6 nM, respectively.

HY-W111226

Fmoc-His(3-Me)-OH	Amino Acid Derivatives Amyloid-β	Cardiovascular Disease
Fmoc-His(3-Me)OH derives Histidine-associating compounds with biological activity. Fmoc-His(3-Me)OH, with Fmoc-citrulline-OH, Fmoc-His(1-Me)-OH together, forms tri-peptides and shows vasodilating effect with EC₅₀s of 2.7-4.7 mM in 1.0 mM Phenylephrine (PE)-contracted aorta rings. Fmoc-His(3-Me)OH (resin) also makes Methyl-His-Gly-Lys (His(3-Me)-Gly-Lys), thus acts as an [Ca²⁺]_i inhibitor. Fmoc-His(3-Me)OH methylates NAHIS02, making it unable to block the Alzheimer's Aβ channel.

Cat. No.	Product Name

HY-L117

Calcium Channel Blocker Library

130 compounds

Calcium channel blockers (CCBs), also called calcium antagonists are compounds that slow the movement of calcium (Ca2+) through calcium channels into the cells of the heart and blood vessel walls. Calcium causes the heart and arteries to squeeze more strongly. By blocking calcium, calcium channel blockers allow blood vessels to relax and open. So calcium channel blockers are usually used to lower blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

MCE supplies a unique collection of 130 calcium channel blockers and antagonists, all of which have the identified inhibitory effect on calcium channel. MCE Calcium Channel Blocker Library is a useful tool for discovery of antihypertensive drugs and cardiovascular disease research.

HY-L089

Mitochondria-Targeted Compound Library

484 compounds

Mitochondria plays an important role in many vital processes in cells, including energy production, fatty-acid oxidation and the Tricarboxylic Acid (TCA) cycle, calcium signaling, permeability transition, apoptosis and heat production. At present, it is recognized that many diseases are associated with impaired mitochondrial function, such as increased accumulation of ROS and decreased OXPHOS and ATP production. Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases, etc. Some small molecule drugs or biologics can act on mitochondria through various pathways, including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca²⁺ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation.

MCE supplies a unique collection of 484 mitochondria-targeted compound that mainly targeting Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc. MCE Mitochondria-Targeted Compound Library is a useful tool for mitochondria-targeted drug discovery and related research.

Cat. No.	Product Name	Type

HY-D1608

BODIPY FL Thapsigargin	Fluorescent Dyes/Probes
BODIPY FL Thapsigargin is a potent green fluorescent dye. BODIPY FL Thapsigargin inhibits intracellular SERCA-type Ca2+ pumps present in the sarcoplasmic/endoplasmic reticulum. BODIPY FL Thapsigargin used for investigation of thapsigargin binding sites in live cells. Storage: protect from light.

HY-104056

Fura Red
Fluorescent Dyes/Probes

Fura Red is a Ca²⁺-sensitive fluorescent dye, which decreases in fluorescence with rising [Ca²⁺].

HY-D1424

Coelenterazine hcp	Fluorescent Dyes/Probes
Coelenterazine hcp is a Coelenterazine analogue. Coelenterazine hcp shows high sensitivity to Ca²⁺. Coelenterazine hcp is suited for monitoring intracellular Ca²⁺.

HY-D1631

Calcium Green-5N AM	Fluorescent Dyes/Probes
Calcium Green-5N AM is a novel *Ca²⁺*-sensitive fluorescent probe. Calcium Green-5N AM shows enhancement in fluorescence intensity on binding Ca²⁺, and can monitor free Ca²⁺ in neurons.

HY-D0121

INDO 1	Fluorescent Dyes/Probes
INDO 1 is a fluorescent Ca²⁺ indicator, binds specifically to Ca²⁺ while emitting fluorescence, the maximum emission wavelength shifts from 485 nm before binding to 410 nm.

HY-D0121A

INDO 1 pentapotassium	Fluorescent Dyes/Probes
INDO 1 pentapotassium is a fluorescent Ca²⁺ indicator, binds specifically to Ca²⁺ while emitting fluorescence, the maximum emission wavelength shifts from 485 nm before binding to 410 nm.

HY-D1702

Mag-Fura-2 tetrapotassium	Fluorescent Dyes/Probes
Mag-Fura-2 tetrapotassium is a UV excitable rational fluorescent Mg²⁺/Ca²⁺ indicator (Ex=334-360 nm, Em=510 nm). Mag-Fura-2 tetrapotassium can be used for the determination of Mg²⁺ and Ca²⁺ concentrations.

HY-D1700

Mag-indo-1/AM	Fluorescent Dyes/Probes
Mag-indo-1/AM is a cell-permeable fluorescent indicator for Mg²⁺ and also for Ca²⁺ (Ex=340-390 nm, Em=410-490 nm). Mag-indo-1/AM can be used to determine intracellular Mg²⁺ and Ca²⁺ concentrations.

HY-101896

Fluo-4 AM
Fluorescent Dyes/Probes

Fluo-4 AM is a?cell-permeable Ca²⁺?indicator. Storage: protect from light.

HY-101897

Fura-2 AM Fura-2 Acetoxymethyl ester	Fluorescent Dyes/Probes
Fura-2 AM is a high affinity, intracellular, UV light-excitable and ratiometric fluorescent Ca²⁺ indicator. Storage: protect from light.

HY-D0202

Arsenazo III	Dyes
Arsenazo III is a dye useful for detection of micromolar concentrations of ionized Ca²⁺. Arsenazo III can be used for determination of thorium, zirconium, uranium and rare earth elements.

HY-145385

Coelenteramide	Fluorescent Dyes/Probes
Coelenteramide is a oxidative product of Coelenterazine (HY-18743). Coelenteramide can form a complex with apoAequorin/Ca²⁺, which is known as blue fluorescent protein (BFP) and shows continuous weak luminescence with Coelenterazine like a luciferase. Coelenteramide can be used as an imaging agent. Storage: protect from light.

HY-D0110A

Fura-2 pentapotassium	Fluorescent Dyes/Probes
Fura-2 pentapotassium is a scaled fluorescent dye that can be used for intracellular calcium imaging with the K_d value of 140 nM. Fura-2 pentapotassium has an emission wavelength of 510 nm and excitation wavelengths of 340 nm or 380 nm and the ratio of 340/380 fluorescence intensity is proportional to the intracellular Ca²⁺ level.

HY-D0716

Fluo-3AM Fluo-3-pentaacetoxymethyl ester	Fluorescent Dyes/Probes
Fluo-3 AM is a fluorecent Ca²⁺ chelator, with high affinity for calcium. Fluo-3 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence.

HY-D1498

Mag-Fluo-4 AM	Fluorescent Dyes/Probes
Mag-Fluo-4 AM is a fluorecent Ca²⁺ chelator, with high affinity for calcium. Mag-Fluo-4 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence.

HY-101902

Quin-2AM Quin-2 acetoxymethyl ester	Fluorescent Dyes/Probes
Quin-2AM is a fluorecent Ca²⁺ chelator, with high affinity for calcium. Quin-2AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence. Storage: protect from light.

HY-D0989

Rhod-2 AM

Fluorescent Dyes/Probes

Rhod-2 is a high-affinity visible light excitation wavelength Ca²⁺ fluorescent probe, Rhod-2, AM is an acetyl methyl ester derivative of Rhod-2, which has cell membrane permeability and can easily enter cells with simple culture. Once it enters the cell, it is sheared by its lactesterase to produce Rhod-2 without membrane permeability, which remains in the cell to perform the corresponding physiological functions. Maximum excitation/emission wavelength: 549/578 nm. Storage: protect from light.

Cat. No.	Product Name	Type

HY-D0157

ZnAF-2 ZnAF2; ZnAF 2; 4-[(2-{Bis[(pyridin-2-YL)methyl]amino}ethyl)amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-YL)benzoic acid	Biochemical Assay Reagents
ZnAF-2, 6-iso- is a cell-impermeable compound that acts as a high-affinity Zn2?-specific fluorescent probe (Kd = 2.7 nM). It exhibits low basal fluorescence with an approximately 51-fold increase in fluorescence intensity upon stoichiometric (1:1) binding to Zn2?. Little affinity for Ca2?, Mg2?, Na? or K?.

HY-100168

BAPTA

Biochemical Assay Reagents

BAPTA is a selective chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA is widely used as an intracellular buffer for investigating the effects of Ca²⁺ release from intracellular stores or influx via Ca²⁺-permeable channels in the plasma membrane. BAPTA can also inhibit phospholipase C activity independently of their role as Ca²⁺ chelators.

HY-100168B

BAPTA tetrapotassium

Biochemical Assay Reagents

BAPTA tetrapotassium is a selective chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrapotassium is widely used as an intracellular buffer for investigating the effects of Ca²⁺ release from intracellular stores or influx via Ca²⁺-permeable channels in the plasma membrane. BAPTA tetrapotassium can also inhibit phospholipase C activity independently of their role as Ca²⁺ chelators.

HY-D0973

EGTA-AM EGTA Acetoxymethyl ester	Biochemical Assay Reagents
EGTA-AM is a membrane permeable form of EGTA, can be passively loaded into cells to generate intracellular EGTA; EGTA-AM is also a Ca²⁺ chelator with slow chelating dynamics.

HY-D0861

EGTA	Biochemical Assay Reagents
EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (K_d) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca²⁺ over Mg²⁺ (Mg²⁺ K_d 1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages.

HY-100545

BAPTA-AM	Biochemical Assay Reagents
BAPTA-AM is a well-known membrane permeable Ca²⁺ chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC₅₀s of 1.3 μM, 1.45 μM and 1.23 μM, respectively.

HY-D0861A

EGTA tetrasodium	Biochemical Assay Reagents
EGTA tetrasodium is a specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (K_d) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca²⁺ over Mg²⁺ (Mg²⁺ K_d 1-10 mM). EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages.

Cat. No.	Product Name	Target	Research Area

HY-P1479

Calmodulin-Dependent Protein Kinase II (290-309)	Autophagy CaMK	Neurological Disease
Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC₅₀ of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II.

HY-P1479A

Calmodulin-Dependent Protein Kinase II(290-309) acetate	Autophagy CaMK	Neurological Disease
Calmodulin-Dependent Protein Kinase II (290-309) acetate is a potent CaMK antagonist with an IC₅₀ of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II.

HY-P1075

CALP3	Calcium Channel	Cancer Neurological Disease
CALP3, a Ca²⁺-like peptide, is a potent Ca²⁺ channel blocker that activates EF hand motifs of Ca²⁺-binding proteins. CALP3 can functionally mimic increased [Ca²⁺]_i by modulating the activity of Calmodulin (CaM), Ca²⁺ channels and pumps. CALP3 has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia.

HY-P1075A

CALP3 TFA	Calcium Channel	Cancer Neurological Disease
CALP3 TFA, a Ca²⁺-like peptide, is a potent Ca²⁺ channel blocker that activates EF hand motifs of Ca²⁺-binding proteins. CALP3 TFA can functionally mimic increased [Ca²⁺]_i by modulating the activity of Calmodulin (CaM), Ca²⁺ channels and pumps. CALP3 TFA has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia.

HY-P0189

ω-Conotoxin GVIA
Calcium Channel Neurological Disease

ω-Conotoxin GVIA is an inhibitor of the N-type Ca²⁺ channel.
HY-P0189A

ω-Conotoxin GVIA TFA
Calcium Channel Neurological Disease

ω-Conotoxin GVIA TFA is an inhibitor of the N-type Ca²⁺ channel.

HY-P1076

CALP2	Calmodulin	Inflammation/Immunology
CALP2 is a calmodulin (CaM) antagonist ( (K_d of 7.9 µM)) with high affinity for binding to the CaM EF-hand/Ca²⁺-binding site. CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca²⁺ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages.

HY-P3965

16-38-Thymosin β4 (cattle)
Myosin Neurological Disease

16-38-Thymosin β4 (cattle) is a Ca²⁺-independent MLCK activator with high affinity.

HY-P1076A

CALP2 TFA	Calmodulin	Inflammation/Immunology
CALP2 TFA is a calmodulin (CaM) antagonist (K_d of 7.9 µM) with high affinity for binding to the CaM EF-hand/Ca²⁺-binding site. CALP2 TFA inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca²⁺ concentrations. CALP2 TFA potently inhibits of adhesion and degranulation. CALP2 TFA is also a strong activator of alveolar macrophages.

HY-P1079

ω-Agatoxin TK	Calcium Channel	Neurological Disease
ω-Agatoxin TK, a peptidyl toxin of the venom of Agelenopsis aperta, is a potent and selective *P/Q type Ca²⁺* channel** blocker. ω-Agatoxin TK inhibits the high K⁺ depolarisation-induced rise in internal Ca²⁺ in cerebral isolated nerve endings with an IC₅₀ of of 60 nM. ω-Agatoxin TK has no effect on L-type, N-type, or T-type calcium channels.

HY-P3811

Autocamtide-3
CaMK Neurological Disease

Autocamtide-3, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca²⁺/calmodulin-dependent kinase II) (CaMK) substrate.

HY-P3617

Glucagon (22-29)	Peptides	Metabolic Disease
Glucagon (22-29) is partial agonist of Glucagon (19–29). Glucagon specifically inhibits the Ca²⁺ pump in liver plasma membranes independently of adenylate cyclase activation.

HY-P0188

ω-Conotoxin MVIIC	Calcium Channel	Neurological Disease
ω-Conotoxin MVIIC is a N- and P/Q-type Ca²⁺ channel blocker, significantly suppresses the 11-keto-βboswellic acid-mediated inhibition of glutamate release.

HY-P2149

Concanavalin A	Antibiotic Apoptosis	Cancer Infection Inflammation/Immunology
Concanavalin A is a Ca²⁺/Mn 2+-dependent and mannose/glucose-binding plant lectin that can be found in jack bean. Concanavalin A can induce programmed cell death.

HY-P0188A

ω-Conotoxin MVIIC TFA	Calcium Channel	Neurological Disease
ω-Conotoxin MVIIC TFA is a N- and P/Q-type Ca²⁺ channel blocker, significantly suppresses the 11-keto-βboswellic acid-mediated inhibition of glutamate release.

HY-P3944

Calmodulin Dependent Protein Kinase Substrate	CaMK	Neurological Disease
Calmodulin Dependent Protein Kinase Substrate is a *Ca²⁺- and calmodulin (CaM)-dependent protein kinase* (CaMK) substrate peptide. Calmodulin Dependent Protein Kinase Substrate is a synthetic peptide substrate for protein kinases.

HY-P3278

Caloxin 2A1	Proton Pump	Metabolic Disease
Caloxin 2A1 is an extracellular *plasma membrane Ca²⁺-ATPase* (PMCA)** peptide inhibitor. Caloxin 2A1 does not affect basal Mg²⁺-ATPase or Na⁺-K⁺-ATPase.

HY-P0271

Syntide 2	CaMK Autophagy	Neurological Disease
Syntide 2, a *Ca²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII)* substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected.

HY-P1080

ω-Agatoxin IVA	Calcium Channel	Neurological Disease
ω-Agatoxin IVA is a potent, selective *P/Q type Ca²⁺* (Cav2.1) channel blocker with IC₅₀s of 2 nM and 90 nM for P-type and Q-type Ca²⁺ channels, respectively. ω-Agatoxin IVA (IC₅₀*, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA also blocks the high potassium-induced release of serotonin and norepinephrine. ω-Agatoxin IVA has no effect on L-type or N-type calcium channels.*

HY-P0271A

Syntide 2 TFA	CaMK	Neurological Disease
Syntide 2 (TFA), a *Ca²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII)* substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected.

HY-P3278A

Caloxin 2A1 TFA	Proton Pump	Metabolic Disease
Caloxin 2A1 TFA is an extracellular *plasma membrane Ca²⁺-ATPase* (PMCA)** peptide inhibitor. Caloxin 2A1 TFA does not affect basal Mg²⁺-ATPase or Na⁺-K⁺-ATPase.

HY-P0256

Apamin Apamine	Potassium Channel	Inflammation/Immunology Neurological Disease
Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of *Ca²⁺*-activated K⁺ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity.

HY-P1247

Calcineurin autoinhibitory peptide	Phosphatase	Neurological Disease
Calcineurin autoinhibitory peptide is a selective inhibitor of Ca²⁺/calmodulin-dependent protein phosphatase (calcineurin), with an IC₅₀ of ~10 μM. Calcineurin autoinhibitory peptide could protect neurons from excitatory neuronal death.

HY-P3943

Calmodulin Dependent Protein Kinase Substrate Analog	CaMK	Neurological Disease
Calmodulin Dependent Protein Kinase Substrate Analog is a *Ca²⁺- and calmodulin (CaM)-dependent protein kinase* (CaMK) substrate peptide. Calmodulin Dependent Protein Kinase Substrate Analog is a synthetic peptide substrate for protein kinases.

HY-P1080A

ω-Agatoxin IVA TFA	Calcium Channel	Neurological Disease
ω-Agatoxin IVA TFA is a potent, selective *P/Q type Ca²⁺* (Cav2.1) channel blocker with IC₅₀s of 2 nM and 90 nM for P-type and Q-type Ca²⁺ channels, respectively. ω-Agatoxin IVA TFA (IC₅₀*, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA TFA also blocks the high potassium-induced release of serotonin and norepinephrine. ω-Agatoxin IVA TFA has no effect on L-type or N-type calcium channels.*

HY-P1247A

Calcineurin autoinhibitory peptide TFA	Phosphatase	Neurological Disease
Calcineurin autoinhibitory peptide TFA is a selective inhibitor of Ca²⁺/calmodulin-dependent protein phosphatase (calcineurin), with an IC₅₀ of ~10 μM. Calcineurin autoinhibitory peptide TFA could protect neurons from excitatory neuronal death.

HY-P0256A

Apamin TFA Apamine TFA	Potassium Channel	Inflammation/Immunology Neurological Disease
Apamin TFA (Apamine TFA) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of *Ca²⁺*-activated K⁺ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity.

HY-P1805

Calmodulin Binding Peptide 1	Calmodulin	Neurological Disease
Calmodulin Binding Peptide 1 is a high affinity (pM) CaM-binding peptide derived from smooth muscle myosin light-chain kinase (MLCK peptide), which strongly inhibits IP3-induced Ca²⁺ release .

HY-P0033A

Argireline acetate Acetyl hexapeptide-3 acetate	Peptides	Neurological Disease
Argireline acetate (Acetyl hexapeptide-3 acetate) is a non-toxic, skin-permeable, antiwrinkle peptide. Argireline acetate significantly inhibits Ca²⁺ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline acetate has antiwrinkle and anti-aging activity.

HY-P0033

Argireline Acetyl hexapeptide-3	Peptides	Neurological Disease
Argireline (Acetyl hexapeptide-3) is a non-toxic, skin-permeable, antiwrinkle peptide. Argireline significantly inhibits Ca²⁺ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline has antiwrinkle and anti-aging activity.

HY-P2471

Neurogranin (48-76), mouse	Calmodulin	Neurological Disease
Neurogranin (48-76), mouse is a peptide corresponding to residues 48-76 of Neurogranin. Neurogranin, a calmodulin-binding protein, is exclusively expressed in the post-synapse, and mediates NMDAR driven synaptic plasticity by regulating the calcium-calmodulin (Ca²⁺-CaM) pathway.

HY-P3156

Syringomycin E	Fungal	Infection
Syringomycin E is an antifungal cyclic lipodepsinonapeptide. Syringomycin E exhibits growth inhibition of Saccharomyces cerevisiae through interaction with the plasma membrane. Syringomycin E causes K⁺ efflux, Ca²⁺ influx, and changes in membrane potential, and is related to channel formation.

HY-123071

Box5	Wnt	Cancer
Box5 is a potent Wnt5a antagonist. Box5 inhibits Wnt5a signaling and inhibits Wnt5a-mediated Ca²⁺ release. Box5 inhibits cell migration. Box5 has the potential for the research of melanoma.

HY-P0190

Iberiotoxin	Potassium Channel	Cardiovascular Disease
Iberiotoxin is a toxin isolated from Buthus tamulus scorpion venom. Iberiotoxin is a selective high conductance high conductance Ca²⁺-activated K⁺ channel inhibitor with a K_d of ~1 nM. Iberiotoxin does not block other types of voltage-dependent ion channels.

HY-P1366

des-Gln14-Ghrelin	GHSR	Metabolic Disease
des-Gln14-Ghrelin is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca²⁺]i in CHO-GHSR62 cells, with an EC₅₀ of 2.4 nM.

HY-P1366A

des-Gln14-Ghrelin TFA	GHSR	Metabolic Disease
des-Gln14-Ghrelin TFA is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca²⁺]i in CHO-GHSR62 cells, with an EC₅₀ of 2.4 nM.

HY-P1437A

Neuropeptide S(Mouse) TFA	Neuropeptide Y Receptor
Neuropeptide S(Mouse) TFA is a potent endogenous neuropeptide S receptor (NPSR) agonist (EC₅₀=3 nM). Neuropeptide S(Mouse) TFA induces mobilization of intracellular Ca²⁺. Neuropeptide S(Mouse) TFA increases locomotor activity and wakefulness in mice. Neuropeptide S(Mouse) TFA also reduces anxiety-like behavior in mice.

HY-P1250

RFRP-3(human) Neuropeptide VF(124-131)(human)	Neuropeptide Y Receptor	Neurological Disease
RFRP-3 (Neuropeptide VF(124-131))(human), a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca²⁺ mobilization. RFRP-3(human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC₅₀ of 0.7 nM.

HY-P1397A

RVD-Hpα TFA	Cannabinoid Receptor
RVD-Hpα TFA is the N-terminally extended form of human hemopressin that acts as a selective CB1 receptor agonist. RVD-Hpα TFA increases intracellular Ca²⁺ levels in cells expressing CB1 receptors in vitro. RVD-Hpα TFA also high affinity CB2 positive allosteric modulator (K_i=50 nM).

HY-P1792

Angiotensin II (1-4), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca²⁺ levels. Angiotensin II also acts at the Na⁺/H⁺ exchanger in the proximal tubules of the kidney.

HY-P1250A

RFRP-3(human) TFA Neuropeptide VF(124-131)(human) TFA	Neuropeptide Y Receptor	Neurological Disease
RFRP-3 (Neuropeptide VF(124-131))(human) TFA, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca²⁺ mobilization. RFRP-3(human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC₅₀ of 0.7 nM.

HY-P1769

Angiotensin II (5-8), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II. Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca²⁺ levels. Angiotensin II also acts at the Na⁺/H⁺ exchanger in the proximal tubules of the kidney.

HY-P1792A

Angiotensin II (1-4), human TFA	Angiotensin Receptor	Endocrinology Metabolic Disease
Angiotensin II (1-4), human (TFA) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca²⁺ levels. Angiotensin II also acts at the Na⁺/H⁺ exchanger in the proximal tubules of the kidney.

HY-P3214

Myosin light chain kinase fragment 11-19 amide MLCK(11-19) amide	Peptides	Cancer
Myosin light chain kinase fragment 11-19 amide (MLCK(11-19) amide) is a substrate-specific peptide inhibitor of MLCK. Myosin light chain kinase fragment 11-19 amide inhibits hypotonicity-induced Ca²⁺ entry. Myosin light chain kinase fragment 11-19 amide can be used in the research of human cervical cancer.

HY-P2967

α-Hemolysin (Staphylococcus aureus)	Peptides	Others
α-Hemolysin (Staphylococcus aureus) is one of the most characteristic virulence factors secreted by Staphylococcus aureus, a polypeptide capable of destroying the host cell plasma membrane. After α-Hemolysin binds to the cell surface, its monomers assemble into a homoheptamer to form a front pore, which then transforms into a mature transmembrane pore water channel, allowing K⁺ and Ca²⁺ ion transport, leading to necrotic death of target cells.

HY-P1077

CALP1	mGluR Phosphodiesterase (PDE) Apoptosis Calmodulin	Inflammation/Immunology
CALP1 is a calmodulin (CaM) agonist (K_d of 88 µM) with binding to the CaM EF-hand/Ca²⁺-binding site. CALP1 blocks calcium influx and apoptosis (IC₅₀ of 44.78 µM) through inhibition of calcium channel opening. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity.

HY-P3316

OSK-1	Potassium Channel	Inflammation/Immunology Neurological Disease
OSK-1 is a potent K_v channel blocker with IC₅₀s of of 0.6 nM, 5.4 nM, 0.014 nM for K_v1.1, K_v1.2 and K_v1.3, respectively. OSK1 is a moderate blocker of Ca²⁺-activated K_Ca3.1 channel with an IC₅₀ of 225 nM. OSK-1 belongs to α-KTx3 toxins and is used as a immunosuppressive agent.

HY-P1077A

CALP1 TFA	mGluR Phosphodiesterase (PDE) Apoptosis Calmodulin	Inflammation/Immunology
CALP1 TFA is a calmodulin (CaM) agonist (K_d of 88 µM) with binding to the CaM EF-hand/Ca²⁺-binding site. CALP1 TFA blocks calcium influx and apoptosis (IC₅₀ of 44.78 µM) through inhibition of calcium channel opening. CALP1 TFA blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 TFA activates CaM-dependent phosphodiesterase activity.

HY-P1821

Myelin Basic Protein MHP4-14	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts.

HY-P4160

PDC31 THG113.31; ILGHXDYK	Prostaglandin Receptor	Endocrinology
PDC31 (THG113.31; ILGHXDYK) is an allosteric and non-competitive inhibitor of FP Prostaglandin Receptor. PDC31 is the D-amino acid-based oligopeptide, is used for smooth muscle contractile agent. PDC31 decreases the strength and duration of uterine contractions in vivo, which can be used for research of preterm labor and primary dysmenorrhea (PD). PDC31 also enhances Ca²⁺-dependent large-conductance K⁺-channel in human myometrial cells.

HY-P2847

Urocortin II, mouse	CRFR	Endocrinology Metabolic Disease
Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor with K_i values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca²⁺/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow.

HY-P1387

β-Amyloid (1-40) (rat)	Amyloid-β Apoptosis	Neurological Disease
β-Amyloid (1-40) (rat) is a rat form of the amyloid β-peptide, which accumulates as an insoluble extracellular deposit around neurons, giving rise to the senile plaques associated with Alzheimer's disease (AD). β-Amyloid (1-40) (rat) increases ⁴⁵Ca²⁺ influx, induces neurodegeneration in the rat hippocampal neurons of the CA1 subfield. β-Amyloid (1-40) (rat) induces apoptosis. β-Amyloid (1-40) (rat) can be used for the research of Alzheimer's disease.

HY-P1345

TLQP-21	Complement System	Endocrinology Neurological Disease
TLQP-21, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor 1 (C3aR1) agonist (EC₅₀: mouse TLQP-21=10.3 μM; human TLQP-21=68.8 μM). TLQP-21 activates C3aR1 to induce an increase of intracellular Ca²⁺. TLQP-21 is used for the research in regulation of nociception and other relevant physiologic functions.

HY-P1345A

TLQP-21 TFA	Complement System	Endocrinology Neurological Disease
TLQP-21 TFA, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor1 (C3aR1) agonist (EC₅₀: mouse TLQP-21=10.3 μM; human TLQP-21=68.8μM). TLQP-21 TFA activates C3aR1 to induce an increase of intracellular Ca²⁺. TLQP-21 TFA is used for the research in regulation of nociception and other relevant physiologic functions.

HY-P1845

PACAP-38 (31-38), human, mouse, rat	ERK EGFR Reactive Oxygen Species Calcium Channel	Neurological Disease
PACAP-38 (31-38), human, mouse, rat is a PAC₁ receptor activator and increases the α-secretase activity. PACAP-38 (31-38), human, mouse, rat elevates cytosolic Ca²⁺, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP-38 (31-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP-38 (31-38), human, mouse, rat can be used for neurotrophic and neuroprotective research.

HY-P1845A

PACAP-38 (31-38), human, mouse, rat TFA	ERK EGFR Reactive Oxygen Species Calcium Channel	Neurological Disease
PACAP-38 (31-38), human, mouse, rat TFA is a PAC₁ receptor activator and increases the α-secretase activity. PACAP-38 (31-38), human, mouse, rat TFA elevates cytosolic Ca²⁺, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP-38 (31-38), human, mouse, rat TFA demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP-38 (31-38), human, mouse, rat TFA can be used for neurotrophic and neuroprotective research.

HY-W111226

Fmoc-His(3-Me)-OH	Amino Acid Derivatives Amyloid-β	Cardiovascular Disease
Fmoc-His(3-Me)OH derives Histidine-associating compounds with biological activity. Fmoc-His(3-Me)OH, with Fmoc-citrulline-OH, Fmoc-His(1-Me)-OH together, forms tri-peptides and shows vasodilating effect with EC₅₀s of 2.7-4.7 mM in 1.0 mM Phenylephrine (PE)-contracted aorta rings. Fmoc-His(3-Me)OH (resin) also makes Methyl-His-Gly-Lys (His(3-Me)-Gly-Lys), thus acts as an [Ca²⁺]_i inhibitor. Fmoc-His(3-Me)OH methylates NAHIS02, making it unable to block the Alzheimer's Aβ channel.

Cat. No.	Product Name	Target	Category

HY-N3729

(-)-Denudatin B Denudatin B	Calcium Channel	Phenylpropanoids Lignans Classification of Application Fields Disease Research Fields Cardiovascular Disease Source classification Plants Piperaceae Piper betle L.
(-)-Denudatin B is an antiplatelet agent. (-)-Denudatin B relaxed vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated Ca2+ channels. And (-)-Denudatin B has nonspecific antiplatelet action

HY-W018035

DL-Glyceric Acid Glyceric Acid (20% in Water,Ca.2 mol/L)	Endogenous Metabolite	Ketones, Aldehydes, Acids Structural Classification Endogenous metabolite Source classification Metabolic Disease Disease Research Fields Classification of Application Fields
DL-Glyceric Acid is a compound that is secreted excessively in the urine by patients suffering from D-glyceric aciduria.

HY-13764

Tetrandrine NSC-77037; d-Tetrandrine	Calcium Channel Potassium Channel Parasite	Alkaloid Dimers Alkaloids Structural Classification Stephania tetrandra S. Moore Menispermaceae Plants Source classification Inflammation/Immunology Disease Research Fields Classification of Application Fields
Tetrandrine (NSC-77037; d-Tetrandrine) is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca²⁺ current (ICa) and Ca²⁺-activated K⁺ current.

HY-75161

(-)-Menthol	TRP Channel Endogenous Metabolite	Terpenoids Other Monoterpenes Disease Research Fields Cancer Classification of Application Fields Source classification Plants Labiatae Eupatorium chinenseL. Endogenous metabolite
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca²⁺-permeable nonselective cation channel, to increase [Ca²⁺]_i. Antitumor activity.

HY-113308A

Taurolithocholic acid sodium salt	Calcium Channel Endogenous Metabolite	Steroids Structural Classification Animals Source classification Metabolic Disease Disease Research Fields Classification of Application Fields
Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent *Ca²⁺* agonist.

HY-142050

(R)-IDHP	Calcium Channel	Structural Classification Phenols Polyphenols Labiatae Plants Hemistepta lyrata Source classification
(R)-IDHP is an isomer of IDHP, a salvia metabolite that exerts vasorelaxant effects by inhibiting Ca²⁺ release and Ca²⁺ inward flow in voltage-dependent and receptor-operated calcium channels in vascular smooth muscle cells. IDHP is used in studies of cardiovascular disease.

HY-133168

Englerin A	TRP Channel	Terpenoids Sesquiterpenes Classification of Application Fields Disease Research Fields Cancer Source classification Plants other families
Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC₅₀s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca²⁺ influx and Ca²⁺ cell overload.

HY-103312

Xestospongin C (-)-Xestospongin C	Calcium Channel Apoptosis	Alkaloids Piperidine Alkaloids Source classification Animals
Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca²⁺ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca²⁺ release from cerebellar microsomes with an IC₅₀ of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca²⁺ signaling in neuronal and nonneuronal cells.

HY-N0601

Ginsenoside Rf Panaxoside Rf	Calcium Channel Endogenous Metabolite	Triterpenes Terpenoids Source classification Plants Araliaceae Panax ginseng C. A. Meyer Endogenous metabolite
Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits *N-type Ca²⁺* channel**.

HY-135897

Urolithin C	Calcium Channel Reactive Oxygen Species Apoptosis Endogenous Metabolite	Phenols Polyphenols Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Endogenous metabolite
Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a *L-type Ca²⁺* channel opener and enhances Ca²⁺ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS)** formation.

HY-N10512

Gangliotetraose Gg4	Others	Saccharides Polysaccharides Structural Classification Neurological Disease Disease Research Fields Classification of Application Fields
Gangliotetraose (Gg4) is a tetrasccharide, exhibits major components including GM1 and its sialylated derivatives. GM1 facilitates efflux of nuclear Ca²⁺ and reduces the level of nuclear Ca²⁺ that characterizes the differentiated neuron. GM1 affects neuronal plasticity and repair mechanisms, as well as neurotrophin release in the brain.

HY-N4237

Saikogenin D	Prostaglandin Receptor Potassium Channel	Terpenoids Triterpenes Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Umbelliferae Ajuga reptans L.
Saikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of *[Ca²⁺]i* due to Ca²⁺ release from intracellular stores.

HY-N4267

Yangambin	Calcium Channel	Phenylpropanoids Lignans Classification of Application Fields Disease Research Fields Cardiovascular Disease Source classification Plants other families
Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca²⁺ influx through voltage-gated Ca²⁺ channels, leading to the reduction in [Ca²⁺]i in vascular smooth muscle cells and consequent peripheral vasodilation. Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC₅₀ of 33.8 μM and for anti-inflammatory activity with an IC₅₀ of 37.4 μM.

HY-N1370

Tanshinone IIA sulfonate sodium Sodium Tanshinone IIA sulfonate; Tanshinone IIA sodium sulfonate	CRAC Channel	Terpenoids Diterpenoids Classification of Application Fields Disease Research Fields Cancer Source classification Plants Labiatae Hemistepta lyrata
Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca²⁺ entry (SOCE), and is used to treat cardiovascular disorders.

HY-N7594

Senecionine acetate O-Acetylsenecionine	Mitochondrial Metabolism	Alkaloids Pyrrole Alkaloids Classification of Application Fields Disease Research Fields Other Diseases Source classification Plants Compositae Erinacea anthyllis Link
Senecionine acetate (O-Acetylsenecionine) is a pyrrolizidine alkaloid. Senecionine acetate inhibits the sequestration of Ca²⁺ in extramitochondrial and mitochondrial compartments possibly by inactivating free sulfhydryl groups.

HY-W010451

1,2,4-Trihydroxybenzene	Calcium Channel	Phenols Polyphenols Classification of Application Fields Disease Research Fields Cardiovascular Disease Source classification Microorganisms
1,2,4-Trihydroxybenzene (Hydroxyhydroquinone), a by-product of coffee bean roasting, increases intracellular Ca²⁺ concentration in rat thymic lymphocytes.

HY-N7063

Nerol	Reactive Oxygen Species Fungal Mitochondrial Metabolism Apoptosis Endogenous Metabolite	Natural Products Classification of Application Fields Disease Research Fields Infection Source classification Plants other families Endogenous metabolite
Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca²⁺ and ROS. Antifungal activity.

HY-N0252

Catharanthine (+)-3,4-Didehydrocoronaridine	Calcium Channel	Indole Alkaloids Alkaloids Disease Research Fields Classification of Application Fields Cardiovascular Disease Source classification Plants Apocynaceae Catharanthus roseus (L.) G. Don
Catharanthine is an alkaloid isolated from Catharanthus roseus, inhibits *voltage-operated L-type Ca²⁺* channel**, with anti-cancer and blood pressure-lowering activity.

HY-N2060

Evocarpine	Apoptosis Bacterial	Alkaloids Quinoline Alkaloids Classification of Application Fields Disease Research Fields Infection Inflammation/Immunology Source classification Plants Rutaceae Evodia rutaecarpa (Juss.) Benth.
Evocarpine, a quinolone alkaloid that could be isolated from Evodiae fructus, inhibitss Ca²⁺ influx through voltage-dependent calcium channels. Antimycobacterial activity.

HY-N0252A

Catharanthine Tartrate (+)-3,4-Didehydrocoronaridine Tartrate	Calcium Channel	Indole Alkaloids Alkaloids Disease Research Fields Cancer Classification of Application Fields Cardiovascular Disease Source classification Plants Apocynaceae Catharanthus roseus (L.) G. Don
Catharanthine Tartrate is an alkaloid isolated from Catharanthus roseus, inhibits *voltage-operated L-type Ca²⁺* channel**, with anti-cancer and blood pressure-lowering activity.

HY-N8493

Mycalolide B	Others	Alkaloids Other Alkaloids Classification of Application Fields Disease Research Fields Other Diseases Source classification Animals
Mycalolide-B is a specific inhibitor of actomyosin ATPase isolated from marine sponge. Mycalolide-B inhibits ATP-induced contraction and Mg²⁺-ATPase activity in the absence of Ca²⁺.

HY-103306

Ryanodine	Others	Terpenoids Structural Classification Diterpenoids other families Ryania speciosa Plants Source classification Biological Pesticide Research Neurological Disease Disease Research Fields Agricultural Research Classification of Application Fields
Ryanodine is a cell permeant ryanodine receptor modulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca²⁺ release depending on its concentrations. Poisonous diterpenoid found in Ryania speciosa.

HY-142087

Beauverolide Ja	Calmodulin Endogenous Metabolite	Structural Classification Natural Products Microorganisms Source classification
Beauverolide Ja, a cyclotetradepsipeptide, is a potent calmodulin (CaM) inhibitor with a K_d of 0.078 μM and a K_i of 0.39 μM for Ca²⁺-CaM. Beauverolide Ja is a secondary metabolite of Isaria fumosorosea.

HY-N11369

Leiurus Quinquestriatus Venom Deathstalker Venom	Potassium Channel	Scorpion Venoms Animals Animal Venoms
Leiurus Quinquestriatus Venom (Deathstalker Venom) is a scorpion venom that can be obtained from Deathstalker. Leiurus Quinquestriatus Venom can inhibit different kinds of Ca²⁺-dependent K⁺ channels.

HY-N6771

Cyclopiazonic acid	Calcium Channel	Pyrrole Alkaloids Indole Alkaloids Alkaloids Other Diseases Disease Research Fields Classification of Application Fields Source classification Microorganisms
Cyclopiazonic acid (CPA), a neurotoxic secondary metabolite (SM) made by Aspergillus flavus, is an inhibitor of endoplasmic reticulum calcium ATPase (Ca²⁺ATPase; SERCA) and a potent inducer of cell death in plants.

HY-116330

Hyperforin	Calcium Channel TRP Channel	Structural Classification Antibiotics Guttiferae Hyperlcurn perforatum L. Plants Source classification
Hyperforin is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin modulates Ca²⁺ levels by activating Ca²⁺-conducting non-selective canonical TRPC6 channels. Hyperforin also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model.

HY-N10772

Albanin A	Calcium Channel Calmodulin Adenylate Cyclase	Structural Classification Other Flavonoids Flavonoids Plants Source classification Moraceae Morus nigra Linn.
Albanin A, a flavonoid, suppresses glutamate release by decreasing Ca²⁺/calmodulin/adenylate Cyclase 1 (AC1) activation in synaptosomes and exerts neuroprotective effect in vivo. Albanin A has anti-inflflammatory activity.

HY-N0252B

Catharanthine Sulfate (+)-3,4-Didehydrocoronaridine Sulfate	Calcium Channel	Alkaloids Indole Alkaloids Classification of Application Fields Disease Research Fields Cardiovascular Disease Source classification Plants Apocynaceae Catharanthus roseus (L.) G. Don
Catharanthine Sulfate ((+)-3,4-Didehydrocoronaridine Sulfate) is an alkaloid isolated from Madagascar periwinkle, inhibits *voltage-operated L-type Ca²⁺* channel**, with anti-cancer and blood pressure-lowering activities.

HY-116330A

Hyperforin dicyclohexylammonium salt Hyperforin DCHA	TRP Channel Calcium Channel	Structural Classification Natural Products Guttiferae Hyperlcurn perforatum L. Plants Source classification
Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca²⁺ levels by activating Ca²⁺-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin dicyclohexylammonium salt modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model.

HY-N6688

Verruculogen	Potassium Channel Bacterial Antibiotic	Structural Classification Natural Products Microorganisms Source classification Infection Disease Research Fields Classification of Application Fields
Verruculogen is a toxin produced mainly by Penicillium and Aspergillus spp. and causes severe tremors in affected animals. Verruculogen inhibits Ca²⁺-activated K⁺ channels. Verruculogen is an M phase inhibitor of the mammalian cell cycle.

HY-N5123

α-L-Rhamnose	Others	Saccharides Monosaccharides Classification of Application Fields Disease Research Fields Other Diseases Source classification Microorganisms
α-L-Rhamnose is a terminal residue of steviol glycosides Dulcoside A and Dulcoside B. α-L-Rhamnose recognizing lectin site of human dermal fibroblasts functions as a signal transducer: modulation of Ca²⁺ fluxes and gene expression.

HY-N11378

Parabuthus Granulatus Venom Granulated Thick-tailed Venom	Calcium Channel Sodium Channel	Scorpion Venoms Animals Animal Venoms
Parabuthus Granulatus Venom (Granulated Thick-tailed Venom) is a scorpion venom that can be obtained from Granulated Thick-tailed scorpion. Two scorpion toxins from the scorpion Parabuthus granulatus can inhibit voltage-gated *Ca²⁺* and Na⁺ channels.

HY-N0607

Ginsenoside Ro Polysciasaponin P3; Chikusetsusaponin 5; Chikusetsusaponin V	Calcium Channel Prostaglandin Receptor	Triterpenes Structural Classification Terpenoids Disease Research Fields Classification of Application Fields Endocrinology Source classification Plants Araliaceae Panax ginseng C. A. Meyer
Ginsenoside Ro (Polysciasaponin P3; Chikusetsusaponin 5; Chikusetsusaponin V) exhibits a *Ca²⁺*-antagonistic antiplatelet effect with an IC₅₀ of 155 μM. Ginsenoside Ro reduces the production of *TXA₂* more than it reduces the activities of COX-1 and TXAS.

HY-N2344

Procyanidin A1 Proanthocyanidin A1	PKC	Flavonoids Biflavones Phenols Polyphenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Research of Health Products Functional Molecules Source classification Plants other families
Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca²⁺ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects.

HY-N0219

Bicuculline (+)-Bicuculline; d-Bicuculline	GABA Receptor	Alkaloids Isoquinoline Alkaloids Source classification Plants Papaveraceae Lamprocapnos spectabilis
Bicuculline ((+)-Bicuculline; d-Bicuculline), as a convulsant alkaloid, is a competitive neurotransmitter GABA_A receptor antagonist (IC₅₀=2 μM). Bicuculline also blocks Ca²⁺-activated potassium (SK) channels and subsequently blocks the slow afterhyperpolarization (slow AHP) ^[1].

HY-P0190

Iberiotoxin	Potassium Channel	Natural Products Classification of Application Fields Disease Research Fields Cardiovascular Disease Source classification Animals
Iberiotoxin is a toxin isolated from Buthus tamulus scorpion venom. Iberiotoxin is a selective high conductance high conductance Ca²⁺-activated K⁺ channel inhibitor with a K_d of ~1 nM. Iberiotoxin does not block other types of voltage-dependent ion channels.

HY-13433

Thapsigargin	Calcium Channel SARS-CoV Apoptosis	Terpenoids Diterpenoids Infection Disease Research Fields Cancer Classification of Application Fields Source classification Plants Umbelliferae Thapsia garganica L.
Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal *Ca²⁺-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types.*

HY-12728

Tautomycin	Phosphatase	Antibiotics Other Antibiotics Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Microorganisms
Tautomycin, an antifungal antibiotic isolated from the bacterium Streptomyces verticillatus, is a potent and specific inhibitor of protein phosphatases 1 and 2A and induces contraction of smooth muscle under Ca²⁺-free conditions, with K_iapp values of 0.16 nM and 0.4 nM for PP1 and PP2A, respectively.

HY-N0742

Absinthin	Others	Terpenoids Triterpenes Classification of Application Fields Disease Research Fields Other Diseases Source classification Plants Compositae Artemisia absinthium
Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor *hTAS2R46, which reduces cytosolic Ca²⁺-rises* induced by histamine by a receptor-specific mechanism mediated by hTAS2R46.

HY-N4104

Agaric acid Agaricinic Acid	Mitochondrial Metabolism	Ketones, Aldehydes, Acids Metabolic Disease Disease Research Fields Classification of Application Fields Source classification Plants Microorganisms
Agaric acid (Agaricinic Acid) is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus igniarius. Agaric acid induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Agaric acid promotes efflux of accumulated Ca²⁺, collapse of transmembrane potential, and mitochondrial swelling. Agaric acid is used to regulate lipid metabolism.

HY-114252

Strophanthidin	Na+/K+ ATPase	Steroids Classification of Application Fields Disease Research Fields Cardiovascular Disease Source classification Plants Brassicaceae Erysimum cheiranthoides Linn.
Strophanthidin is a naturally available cardiac glycoside. Strophanthidin 0.1 and 1 nmol/L increases and 1~100 µmol/L inhibits the Na+/K+-ATPase activities, but Strophanthidin 10 and 100 nmol/L does not affect Na+/K+-ATPase activities in cardiac sarcolemmal. Strophanthidin increases both diastolic and systolic intracellular Ca²⁺ concentration.

HY-N6778

Paxilline	Potassium Channel Calcium Channel	Indole Alkaloids Alkaloids Terpenoids Structural Classification Diterpenoids Microorganisms other families Plants Source classification Neurological Disease Disease Research Fields Classification of Application Fields
Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline also inhibits the *sarco/endoplasmic reticulum Ca²⁺* ATPase (SERCA) with IC₅₀*s between 5 μM and 50 μM for differing isoforms. Paxilline possesses significant anticonvulsant activity.*

HY-125703

Ferutinin	Estrogen Receptor/ERR Apoptosis	Terpenoids Sesquiterpenes Classification of Application Fields Disease Research Fields Cancer Endocrinology Infection Source classification Plants Umbelliferae
Ferutinin, a natural terpenoid compound, is an estrogen receptor ERα agonist and estrogen ERβ-receptor agonist/antagonist with IC₅₀s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca²⁺-ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities.

HY-N11324

Bitis Nasicornis Venom Rhinoceros Viper Venom	Others	Snake Venoms Animals Animal Venoms
Bitis Nasicornis Venom (Rhinoceros Viper Venom) is a snake venom that can be obtained from Bitis Nasicornis. Bitis Nasicornis Venom has anticoagulant activity. Bitis Nasicornis Venom also has insulinotropic effect, and can be used for the research of diabetes. Bitis Nasicornis Venom can increase in intracellular Ca²⁺ concentration and hence a contraction of the the isolated aortic strip in rabbit.

HY-N2500

Deoxypodophyllotoxin	Microtubule/Tubulin Apoptosis Autophagy	Phenylpropanoids Structural Classification Lignans Umbelliferae other families Plants Anthriscus sylvestris Source classification Infection Disease Research Fields Classification of Application Fields Cardiovascular Disease
Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from Anthriscus sylvestris. Deoxypodophyllotoxin, targets the microtubule, has a major impact in oncology not only as anti-mitotics but also as potent inhibitors of angiogenesis. Deoxypodophyllotoxin induces cell autophagy and *apoptosis. Deoxypodophyllotoxin evokes increase of intracellular Ca²⁺* concentrations in DRG neurons.

HY-129440

N-(p-Coumaroyl) Serotonin	PDGFR	Phenols Polyphenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Compositae Carthamus tinctorius L.
N-(p-Coumaroyl) Serotonin is a polyphenol isolated from the seeds of safflower and has antioxidative, anti-atherogenic and anti-inflammatory properties. N-(p-Coumaroyl) Serotonin inhibits PDGF-induced on phosphorylation of PDGF receptor and Ca²⁺ release from sarcoplasmic reticulum. N-(p-Coumaroyl) Serotonin ameliorates atherosclerosis and distensibility of the aortic wall in vivo and is usually used for the atherosclerosis research.

HY-N2359

Chelerythrine	PKC Bcl-2 Family Apoptosis Autophagy	Isoquinoline Alkaloids Alkaloids Inflammation/Immunology Metabolic Disease Disease Research Fields Classification of Application Fields Source classification Plants Papaveraceae Macleaya cordata (Willd.) R. Br.
Chelerythrine is a natural alkaloid, acts as a potent and selective Ca²⁺/phospholopid-dependent PKC antagonist, with an IC₅₀ of 0.7 μM. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy.

HY-N6687

Calcimycin A-23187; Antibiotic A-23187	Bacterial Fungal Apoptosis Autophagy Antibiotic	Antibiotics Polyether Antibiotics Structural Classification Microorganisms Source classification Infection Disease Research Fields Classification of Application Fields
Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis.

HY-N6732

K-252a SF2370; Antibiotic K 252a; Antibiotic SF 2370	PKC PKA CaMK Trk Receptor Autophagy Antibiotic	Indole Alkaloids Alkaloids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Microorganisms
K-252a, a staurosporine analog, inhibits protein kinase, with IC₅₀ values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca²⁺/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively. K-252a is a potent inhibitor (IC₅₀ of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene.

HY-100560

Abscisic acid (S)-(+)-Abscisic acid; ABA	Endogenous Metabolite Proton Pump	Sesquiterpenes Terpenoids Structural Classification Microorganisms other families Endogenous metabolite Plants Animals Source classification Metabolic Disease Disease Research Fields Classification of Application Fields
Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H⁺-ATPase) and leads to the plasma membrane depolarization in a Ca²⁺-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome.

HY-N0081

(±)-Praeruptorin A	Calcium Channel	Phenylpropanoids Coumarins Classification of Application Fields Disease Research Fields Infection Source classification Plants Umbelliferae Salvia sahendica Boiss. & Buhse
(±)-Praeruptorin A is the di-esterified product of cis-khellactone (CKL) and the major active ingredient in Peucedani Radix which consists of the dried roots of Peucedanum praeruptorumDunn (Apiaceae). (±)-Praeruptorin A has been widely employed as one of the famous traditional Chinese medicines (TCMs) for the treatment of cough with thick sputum and dyspnea, nonproductive cough and upper respiratory infections for centuries in China. (±)-Praeruptorin A has dramatically therapeutic effects on hypertension mainly through acting as a *Ca²⁺*-influx blocker.

HY-B1671

(+)-Kavain	GABA Receptor Sodium Channel Calcium Channel	Other Phenylpropanoids Phenylpropanoids Source classification Plants Piperaceae Piper methysticum G.Forst.
(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na⁺ and Ca²⁺ channels. (+)-Kavain is shown to bind at the α4β2δ GABA_A receptor and potentiate GABA efficacy. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied.

HY-N0385

Gomisin J	AMPK Calcium Channel	Phenylpropanoids Monophenols Phenols Lignans Disease Research Fields Classification of Application Fields Cardiovascular Disease Source classification Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.
Gomisin J is a small molecular weight lignan found in Schisandra chinensis and has been demonstrated to have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca²⁺/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells. gomisin J has potential benefits in treating nonalcoholic fatty liver disease.

HY-N6687A

Calcimycin hemicalcium salt A-23187 hemiCalcium salt; Antibiotic A-23187 hemiCalcium salt	Bacterial Fungal Apoptosis Autophagy Antibiotic	Antibiotics Polyether Antibiotics Structural Classification Microorganisms Source classification Infection Disease Research Fields Classification of Application Fields
Calcimycin hemicalcium salt (A-23187 hemicalcium salt) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces *apoptosis*.

HY-N3945

Glaucine O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396	Phosphodiesterase (PDE) Calcium Channel Adrenergic Receptor Dopamine Receptor Influenza Virus	Isoquinoline Alkaloids Alkaloids Inflammation/Immunology Infection Disease Research Fields Classification of Application Fields Source classification Plants Papaveraceae Glaucium flavum other families
Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with K_is of 3.4 µM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a *Ca²⁺* entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities.

HY-108496

Sphingosine-1-phosphate S1P	Endogenous Metabolite LPL Receptor	Ketones, Aldehydes, Acids Structural Classification Endogenous metabolite Source classification Disease Research Fields Classification of Application Fields Endocrinology
Sphingosine-1-phosphate (S1P) is an agonist of S1P_1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca²⁺ as an extracellular ligand for G protein-coupled receptors. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids.

HY-N1584

Halofuginone RU-19110	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel	Alkaloids Piperidine Alkaloids Classification of Application Fields Disease Research Fields Cardiovascular Disease Infection Inflammation/Immunology Source classification Plants Saxifragaceae Dichroa febrifuga Lour
Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca²⁺ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.

HY-N1584A

Halofuginone hydrobromide RU-19110 hydrobromide	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel	Alkaloids Piperidine Alkaloids Classification of Application Fields Disease Research Fields Cardiovascular Disease Infection Inflammation/Immunology Source classification Plants Saxifragaceae Dichroa febrifuga Lour
Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.

HY-N1940

β-Anhydroicaritin	Interleukin Related TNF Receptor MMP	Flavonols Flavonoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Plants Burseraceae Boswellia carterii
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties. β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats. β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca²⁺, and markedly decreases iNOS protein expression.

HY-N0043

Ginsenoside Rd Gypenoside VIII	NF-κB COX Calcium Channel Cytochrome P450 Endogenous Metabolite	Triterpenes Terpenoids Disease Research Fields Cancer Classification of Application Fields Cardiovascular Disease Source classification Plants Araliaceae Panax ginseng C. A. Meyer Endogenous metabolite
Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC₅₀ of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of *COX-2* and iNOS mRNA. Ginsenoside Rd also inhibits *Ca²⁺* influx. Ginsenoside Rd inhibits *CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC₅₀*s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.

HY-N0515

Ophiopogonin D	PPAR NF-κB Calcium Channel	Steroids Disease Research Fields Classification of Application Fields Cardiovascular Disease Source classification Plants Liliaceae Ophiopogon japonicus (L. f.) Ker-Gawl.
Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca²⁺ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years.

Species:	Human (3) Mouse (1)
Tag:	His (4) SUMO (1)
Source:	E. coli (4)

Cat. No.	Product Name	Species	Source

HY-P72861

Carbonic Anhydrase 2 Protein, Mouse (His)
Carbonic anhydrase 2; Carbonic anhydrase C; CaC; Ca-II; Ca2
Mouse E. coli
HY-P72860

Carbonic Anhydrase 2 Protein, Human (His)
Carbonic anhydrase 2; Carbonic anhydrase C; CaC; Ca-II; Ca2
Human E. coli

HY-P72113

CAPN1 Protein, Human (His) Ca2 activated neutral protease; Calcium activated neutral proteinase; CaNP1; CaNPL 1; CaNPL1; CaPN 1; CaPN1; Cell proliferation inducing protein 30; Cell proliferation-inducing gene 30 protein; Micromolar Calpain; Micromolar-Calpain; Mu Calpain; muCaNP; muCL	Human	E. coli

HY-P72109

CACNA2D1 Protein, Human (His-SUMO) Ca2D1_HUMAN; CaCN A2; CaCNA2; Cacna2d1; CaCNL2A; Calcium channel L type alpha 2 polypeptide; Calcium channel voltage dependent alpha 2/delta subunit 1; CCHL2A; Dihydropyridine receptor alpha 2 subunit; Dihydropyridine sensitive L type Calcium channel alpha 2/delta subunit; Dihydropyridine sensitive L type Calcium channel subunits alpha 2/delta; L type Calcium channel subunit alpha 2; MHS 3; MHS3; Voltage dependent Calcium channel subunit alpha 2/delta 1; Voltage gated Calcium channel subunit alpha 2/delta 1; Voltage-dependent Calcium channel subunit delta-1; Voltage-gated Calcium channel subunit alpha-2/delta-1	Human	E. coli

Cat. No.	Product Name

HY-17404S

Cilnidipine-d7
Cilnidipine-d₇ is deuterium labeled Cilnidipine. Cilnidipine is a long-acting, second-generation dihydropyridine Ca2+-channel blocker on L and N-type Ca2+ channel[1][2][3][4]. Antihypertensive effects[5].

HY-113308AS

Taurolithocholic acid-d4 sodium
Taurolithocholic acid-d₄ (sodium) is the deuterium labeled Taurolithocholic acid (sodium salt). Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist[1].

HY-B0493S1

Niflumic acid-13C6
Niflumic acid-¹³C₆ is the ¹³C_{6_{labeled Niflumic acid. Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.}}

HY-113308AS2

Taurolithocholic acid-d4-1 sodium
Taurolithocholic acid-d₄-1 (sodium) is the deuterium labeled Taurolithocholic acid. Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist[1].

HY-113308AS1

Taurolithocholic Acid-d5 sodium salt
Taurolithocholic Acid-d₅ (sodium) is the deuterium labeled Taurolithocholic acid sodium salt. Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist[1][2].

HY-14656S

Diltiazem-d3 hydrochloride
Diltiazem-d₃ (hydrochloride) is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2].

HY-B0493S

Niflumic Acid-d5
Niflumic Acid-d₅ is the deuterium labeled Niflumic acid. Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis[1][2].

HY-145542S

Isovalerylcarnitine-d9 chloride
Isovalerylcarnitine-d₉ (chloride) is the deuterium labeled Isovalerylcarnitine (chloride)[1]. Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca2+-dependent proteinase (calpain) of human neutrophils[2].

HY-14656S1

Diltiazem-(acetoxy-d3) (hydrochloride)
Diltiazem-(acetoxy-d₃) (hydrochloride) is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2].

HY-B0632S

Diltiazem-d6
Diltiazem-d₆ is the deuterium labeled Diltiazem. Diltiazem is an orally active L-type Ca2+ channel blocker, with antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris[1][2][3].

HY-116429S

Maresin 1-d5
Maresin 1-d₅ is the deuterium labeled Maresin 1. Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity[1][2][3].

HY-101329S

Anthracene-9-carboxylic acid-d9
Anthracene-9-carboxylic acid-d₉ is the deuterium labeled Anthracene-9-carboxylic acid[1]. Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells[2].

HY-107855S

DL-Mevalonolactone-d7
DL-Mevalonolactone-d₇ is the deuterium labeled DL-Mevalonolactone. DL-Mevalonolactone ((±)-Mevalonolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (∆Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2].

HY-107855S1

DL-Mevalonolactone-d3

DL-Mevalonolactone-d₃ is the deuterium labeled DL-Mevalonolactone[1]. DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (?Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[2][3].

HY-12542S

Dantrolene-13C3

Dantrolene-¹³C₃ is the ¹³C_{3_{labeled Dantrolene. Dantrolene (F368), a muscle relaxant, non-competitively inhibits human erythrocyte glutathione reductase. Ki and IC50 values are 111.6 μM and 52.3 μM, respectively. Dantrolene is a ryanodine receptor antagonist and Ca2+ signaling stabilizer. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome.}}

HY-108496S

Sphingosine-1-phosphate-d7

Sphingosine-1-phosphate-d₇ is the deuterium labeled Sphingosine-1-phosphate. Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2].

HY-N0215S14

L-Phenylalanine-15N,d8

L-Phenylalanine-¹⁵N,d₈ is the deuterium and ¹⁵N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-103309S

ML218-d9

ML218-d₉ is the deuterium labeled ML218. ML218 is a potent, selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC50s of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, KATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier[1].

HY-B1221S1

Flufenamic acid-13C6

Flufenamic acid-¹³C₆ is the ¹³C₆ labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca²⁺ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

HY-B1221S

Flufenamic acid-d4

Flufenamic acid-d₄ is deuterium labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca²⁺ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

Cat. No.	Product Name	Application	Reactivity

HY-P80696

GRP78 BiP (YP6071) Mouse mAb HSPA5; GRP78; 78 kDa glucose-regulated protein; GRP-78; Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; Heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein; BiP	WB, ICC/IF, IP	Human, Mouse, Rat
Mouse Monoclonal Antibody to GRP78 BiP

Ca2

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

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Natural
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