Search Result

Isoforms Recommended:	Caspase 1

Results for "

Caspase-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Caspase (41) Adenosine Receptor (1) AIM2 (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) Apoptosis (10) Bacterial (1) Cathepsin (1) Cholinesterase (ChE) (1) COX (2) DNA/RNA Synthesis (1) Drug Metabolite (1) Fluorescent Dye (2) HIV (1) Influenza Virus (1) Integrin (2) Interleukin Related (8) Isotope-Labeled Compounds (1) Lactate Dehydrogenase (1) NF-κB (1) NOD-like Receptor (NLR) (10) Pyroptosis (3) Reactive Oxygen Species (2) RIP kinase (1) SARS-CoV (1) Sodium Channel (1) TNF Receptor (2) Tyrosinase (2) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (19) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (36) Neurological Disease (7)

By Targets:

Caspase (41)

Adenosine Receptor (1)

AIM2 (1)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (1)

Apoptosis (10)

Bacterial (1)

Cathepsin (1)

Cholinesterase (ChE) (1)

COX (2)

DNA/RNA Synthesis (1)

Drug Metabolite (1)

Fluorescent Dye (2)

HIV (1)

Influenza Virus (1)

Integrin (2)

Interleukin Related (8)

Isotope-Labeled Compounds (1)

Lactate Dehydrogenase (1)

NF-κB (1)

NOD-like Receptor (NLR) (10)

Pyroptosis (3)

Reactive Oxygen Species (2)

RIP kinase (1)

SARS-CoV (1)

Sodium Channel (1)

TNF Receptor (2)

Tyrosinase (2)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (19)

Cardiovascular Disease (1)

Infection (3)

Inflammation/Immunology (36)

Neurological Disease (7)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Caspase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16990

Ac-YVAD-cmk 5+ Cited Publications Caspase-1 Inhibitor II	Caspase	Inflammation/Immunology
Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective *caspase-1* (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases ^[1] .

HY-P10084

Ac-VAD-pNA

Caspase Others

Ac-VAD-pNA is a caspase-1 substrate. Ac-VAD-pNA can be used to detect caspase-1 activity ^[1].
HY-P5974

Z-YVAD-pNA

Z-Tyr-Val-Ala-Asp-pNA
Caspase Others

Z-YVAD-pNA (Z-Tyr-Val-Ala-Asp-pNA) is a caspase-1 substrate ^[1].
HY-P5938

Ac-AAVALLPAVLLALLAP-YVAD-CHO

Caspase Cancer

Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable caspase-1 inhibitor that has antitumor activity ^[1].

Ac-VAD-pNA	Caspase	Others
Ac-VAD-pNA is a *caspase-1* substrate. Ac-VAD-pNA can be used to detect caspase-1 activity ^[1].

Z-YVAD-pNA Z-Tyr-Val-Ala-Asp-pNA	Caspase	Others
Z-YVAD-pNA (Z-Tyr-Val-Ala-Asp-pNA) is a *caspase-1* substrate ^[1].

Ac-AAVALLPAVLLALLAP-YVAD-CHO	Caspase	Cancer
Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable *caspase*-1 inhibitor that has antitumor activity ^[1].

HY-131204

CZL80	Caspase	Neurological Disease
CZL80, a brain-penetrable *caspase-1* inhibitor with an IC₅₀ of 0.01 μM, could be used in the study of febrile seizures and later enhanced epileptogenic susceptibility ^[1].

HY-P2617

Ac-WEHD-AFC	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC is a *fluorogenic caspase-1* substrate*. Ac-WEHD-AFC can measure caspase-1* fluorogenic activity and can be used for the research of tumor and inflammation ^[1].

HY-P2617A

Ac-WEHD-AFC TFA	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC TFA is a *fluorogenic caspase-1* substrate*. Ac-WEHD-AFC TFA can measure caspase-1* fluorogenic activity and can be used for the research of tumor and inflammation ^[1].

HY-152670

JC2-11	NOD-like Receptor (NLR) AIM2	Inflammation/Immunology
JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4, absent in melanoma 2 (AIM 2) and non-canonical (NC) inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of *IL-1β* and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1 ^[1].

HY-156413

NLRP3 agonist 1	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3 agonist 1 (compound 23) is a potent and orally active NLRP3 agonist. NLRP3 agonist 1 can activate the enzyme Caspase-1 to cleave pro-IL-1β and pro-IL-18 proinflammatory cytokines into their mature forms ^[1].

HY-156415

NLRP3 agonist 2

NOD-like Receptor (NLR) Inflammation/Immunology

NLRP3 agonist 2 (compound 22) is a orally active NLRP3 agonist.NLRP3 agonist 2 activates Caspase-1 in THP1 cells ^[1].

NLRP3 agonist 2	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3 agonist 2 (compound 22) is a orally active NLRP3 agonist.NLRP3 agonist 2 activates *Caspase-1* in THP1 cells ^[1].

HY-121988

INF4E	NOD-like Receptor (NLR)	Inflammation/Immunology
INF4E is a potent NLRP3 inflammasome inhibitor. INF4E inhibits caspase-1 and NLRP3 ATPase activities. INF4E shows protection against the IR-induced myocardial injury and dysfunction ^[1] .

HY-P2091

Ac-YVAD-pNA	Caspase	Inflammation/Immunology
Ac-YVAD-pNA is a specific *Caspase-1* substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes ^[1] .

HY-W792412

Z-YVAD-CMK

Caspase Cancer

Z-YVAD-CMK is a caspase-1 and caspase-3 inhibitor ^[1].
HY-136728

Ac-YVAD-AOM

Caspase Cancer

Ac-YVAD-AOM is the inhibitor of caspase-1 that shows antitumor activity ^[1].
HY-P4547

Ac-Trp-Glu-His-Asp-AMC

AC-WEHD-AMC
Caspase Others

Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 ^[1].

Z-YVAD-CMK	Caspase	Cancer
Z-YVAD-CMK is a *caspase-1* and *caspase-3* inhibitor ^[1].

Ac-YVAD-AOM	Caspase	Cancer
Ac-YVAD-AOM is the inhibitor of *caspase*-1 that shows antitumor activity ^[1].

Ac-Trp-Glu-His-Asp-AMC AC-WEHD-AMC	Caspase	Others
Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 ^[1].

HY-10081

GS-6201 1 Publications Verification CVT-6883	Adenosine Receptor	Inflammation/Immunology
GS-6201 (CVT-6883) is a selective adenosine A2B receptor antagonist. GS-6201 displays high affinity and selectivity for the human adenosine A2B receptors (K_i=22 nM) ^[1]. GS-6201 reduces caspase-1 activity in the heart, and attenuates cardiac remodeling after acute myocardial infarction (AMI) in the mouse . GS-62013 attenuates the airway reactivity induced by NECA, AMP, or allergen in sensitized mice .

HY-P2377

Ac-YVAD-AFC

Fluorescent Dye Others

Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm ^[1] .

Ac-YVAD-AFC	Fluorescent Dye	Others
Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm ^[1] .

HY-P2616

Mca-YVADAP-Lys(Dnp)-OH	Caspase Angiotensin-converting Enzyme (ACE)	Others
Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate for *caspase-1* and angiotensin-converting enzyme 2 (ACE2) ^[1].

HY-P4535

Ac-Trp-Glu-His-Asp-Aldehyde

Caspase Inflammation/Immunology

Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective caspase-1 inhibitor with a K_i value of 56 pM ^[1] .

Ac-Trp-Glu-His-Asp-Aldehyde	Caspase	Inflammation/Immunology
Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective *caspase-1* inhibitor with a K_i value of 56 pM ^[1] .

HY-111662

Fc 11a-2	NOD-like Receptor (NLR)	Inflammation/Immunology
Fc 11a-2, a benzimidazole compound, is an orally active and potent NLRP3 inflammasome inhibitor. Fc 11a-2 restrains the formation of NLRP3 inflammasome by inhibiting activation of caspase-1 and thus the activation of IL-1b/IL-18. Fc 11a-2 prevents the development of Dextran sulfate sodium (DSS; HY-116282C)-induced murine experimental colitis ^[1] .

HY-153068

CZL55

Caspase Inflammation/Immunology

CZL55 is a caspase-1 inhibitor with an IC₅₀ value of 24 nM. CZL55 can be used for the research of febrile seizures (FS) ^[1].
HY-P2616A

Mca-YVADAP-Lys(Dnp)-OH TFA

Cholinesterase (ChE) Caspase Others

Mca-YVADAP-Lys(Dnp)-OH TFA is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) ^[1].

CZL55	Caspase	Inflammation/Immunology
CZL55 is a *caspase-1* inhibitor with an IC₅₀ value of 24 nM. CZL55 can be used for the research of febrile seizures (FS) ^[1].

Mca-YVADAP-Lys(Dnp)-OH TFA	Cholinesterase (ChE) Caspase	Others
Mca-YVADAP-Lys(Dnp)-OH TFA is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) ^[1].

HY-P5122

Z-LEED-FMK	Caspase	Inflammation/Immunology
Z-LEED-FMK is a *caspase-13* and *caspase-4* inhibitor. Z-LEED-FMK also inhibits caspase-1 processing in S. typhimurium-infected macrophages ^[1] .

HY-P3761

Ac-Tyr-Val-Lys-Asp-aldehyde	Caspase	Others
Ac-Tyr-Val-Lys-Asp-aldehyde is a *caspase-1* inhibitor, can be used for disease research including anemia-associated to chronic diseases, chemotherapy-induced anemia and Diamond-Blackfan anemia ^[1].

HY-W041489

Chelidonic acid 1 Publications Verification	NF-κB Caspase	Inflammation/Immunology Cancer
Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and *caspase-1* ^[1]. Chelidonic acid is a glutamate decarboxylase inhibitor, with a K_i of 1.2 μM .

HY-141622

SDZ 224-015	Interleukin Related Caspase SARS-CoV	Infection Inflammation/Immunology
SDZ 224-015 is an orally active inhibitor of the **interleukin-1 beta (IL-1β) converting enzyme and caspase-1**. SDZ 224-015 possesses anti-COVID-19 activity, targeting M ^pro (IC₅₀ of 30 nM) ^[1] .

HY-101019

Ossirene 1 Publications Verification AS101
Ossirene (AS101), an immunomodulatory tellurium compound, is a potent *IL-1β* inhibitor ^[1]. Ossirene abolishes phosphorylation of STAT3 by inhibiting IL-10. Ossirene potently inhibits *Caspase-1* and is used for the autoimmune diseases and certain malignancies .

HY-120019

Ac-YVAD-CHO L-709049	Interleukin Related Apoptosis Caspase	Inflammation/Immunology
Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human K_i values of 3.0 and 0.76 nM. Ac-YVAD-CHO is also a *caspase-1* inhibitor. Ac-YVAD-CHO can suppress the production of mature IL-lβ ^[1] .

HY-120019A

Ac-YVAD-CHO acetate L-709049 acetate	Interleukin Related Caspase Apoptosis	Inflammation/Immunology
Ac-YVAD-CHO (L-709049) acetate is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human K_i values of 3.0 and 0.76 nM. Ac-YVAD-CHO acetate is also a *caspase-1* inhibitor. Ac-YVAD-CHO acetate can suppress the production of mature IL-lβ ^[1] .

HY-13205

Belnacasan 80+ Cited Publications VX-765	Caspase	Inflammation/Immunology
Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with K_is of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC₅₀ of ~0.7 μM ^[1] .

HY-146765

AMS-17	NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
AMS-17 is a potent NLRP3 inhibitor, inhibiting microglia activation in vitro and in vivo. AMS-17 also inhibits cytokines such as caspase-1, TNF-α, IL-1β and inducible nitric oxide synthase (iNOS) in N9 cells. AMS-17 can be used for researching inflammation-associated neurological disorders ^[1].

HY-N0619

Mulberroside A 2 Publications Verification	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) ^[1]. Mulberroside A decreases the expressions of TNF-α, *IL-1β, and IL-6* and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-P0109

(S,S)-Z-FA-FMK
(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position ^[1] .

HY-101092

QS-21 Stimulon
QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and *Th1* cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18 ^[1] .

HY-N0619A

cis-Mulberroside A Mulberroside D	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) ^[1]. Mulberroside A decreases the expressions of TNF-α, *IL-1β, and IL-6* and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-148258

GDC-2394	NOD-like Receptor (NLR) Interleukin Related Caspase	Inflammation/Immunology
GDC-2394 is an orally active and selective NLRP3 inhibitor, and also inhibits *IL-1β* with IC₅₀s of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β). GDC-2394 inhibits NLRP3-induced caspase-1 activity without inhibiting NLRC4-dependent inflammasome activation ^[1] .

HY-B1138

Fenbufen CL-82204	COX Caspase	Inflammation/Immunology
Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against *COX-1* and COX-2 with IC₅₀s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor ^[1] .

HY-P10142

Ac-YEVD-AMC	Fluorescent Dye	Others
Ac-YEVD-AMC is a fluorescent substrate of *caspase-1/11*. Ac-YEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection when treating with cell lysate ^[1].

HY-155194

P2X7 receptor antagonist-4	Others	Inflammation/Immunology
P2X7 receptor antagonist-4 (Compound 14a) is a P2X7R antagonist. The P2X7 receptor antagonist-4 values of P2X7R IC₅₀ in human and mouse are 64.7 and 10.1 nM, respectively. P2X7 receptor antagonist-4 can inhibit the activation of NLRP3 inflammasome, thereby inhibiting the expression of caspase-1, gasdermin D, IL-1β and IL-18 in the damaged kidney of sepsis mice ^[1].

HY-B1138S

Fenbufen-d9	Isotope-Labeled Compounds COX Caspase	Inflammation/Immunology
Fenbufen-d₉ (CL-82204-d9) is the deuterium labeled Fenbufen. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor[1][2][3][4][5].

HY-P0111

Z-WEHD-FMK 2 Publications Verification Z-WE(OMe)HD(OMe)-FMK	Caspase Cathepsin	Cancer
Z-WEHD-FMK is a potent, cell-permeable and irreversible *caspase-1/5* inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC₅₀=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis ^[1] .

HY-155759

HMGB1-IN-2	Others	Inflammation/Immunology Cancer
HMGB1-IN-2 (compound 15) is an inhibitor of highly conserved nuclear protein (HMGB1), showing NO inhibitory effect with IC₅₀ value of 20.2 μM in RAW264.7 cells. HMGB1-IN-2 (30 μM) decreases the level of IL-1 β, TNF-α, caspase-1 p20, inhibits the phosphorylation of NF-κB p65, exhibits anti-apoptotic activity. HMGB1-IN-2 (15 mg/kg; ip) relives kidney injury in septic acute kidney injury mouse. HMGB1-IN-2 inhibits Huh7 cells and A549 cells with IC₅₀s of 77.0 μM, and 82.0 μM, respectively ^[1].

HY-12412

ML132 NCGC-00183434	Caspase	Inflammation/Immunology Cancer
ML132 (NCGC-00183434) is a selective *caspase 1* inhibitor with an IC₅₀ of 34.9 nM. ML132 shows good stability that can be utilized as molecular probes of *caspase 1*. ML132 can be used for research in the field of anti-cancer and anti-inflammatory ^[1].

HY-145910

NLRP3-IN-6

NOD-like Receptor (NLR) Neurological Disease Inflammation/Immunology

NLRP3-IN-6 (Compound 34) is a selective NLRP3 inflammasome inhibitor ^[1].

NLRP3-IN-6	NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
NLRP3-IN-6 (Compound 34) is a selective NLRP3 inflammasome inhibitor ^[1].

HY-145911

NLRP3-IN-7	NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
NLRP3-IN-7 (Compound 36) is a selective NLRP3 inflammasome inhibitor. NLRP3-IN-7 effectively blocks the assembly of the NLRP3 inflammasome ^[1].

HY-P1093

Ac-LEHD-AFC

Caspase Others

Ac-LEHD-AFC is a fluorescent substrate for caspase-9, can be used to assess the activity of caspase .
HY-130476

Satratoxin G

Caspase Apoptosis Cancer

Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of caspase .

Ac-LEHD-AFC	Caspase	Others
Ac-LEHD-AFC is a fluorescent substrate for caspase-9, can be used to assess the activity of caspase .

HY-112226

VRT-043198 2 Publications Verification	Caspase Drug Metabolite	Inflammation/Immunology
VRT-043198, the agent metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. VRT-043198 exhibits K_i values of 0.8 nM and 0.6 nM for ICE/caspase-1 and caspase-4, respectively ^[1].

HY-111675

Ac-FLTD-CMK 4 Publications Verification	Caspase Pyroptosis	Inflammation/Immunology
Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against *caspases-1* (IC₅₀ of 46.7 nM), *caspases-4* (IC₅₀ of 1.49 μM), *caspases-5* (IC₅₀ of 329 nM), and *caspases-11* , but not the apoptotic caspases such as caspase-3 ^[1].

HY-N12235

Sarglaroids F	Caspase	Inflammation/Immunology
Sarglaroids F (compound 6) is an anti-inflammatory agent isolated from the roots of Grass Coral. Sarglaroids F inhibits LPS/ATP-induced IL-1β release by affecting K+ efflux and reducing Caspase-1(P20) levels. Sarglaroids F is not cytotoxic to RAW264.7 cells ^[1].

Cat. No.	Product Name

HY-L059

Pyroptosis Compound Library

1240 compounds

Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc.

MCE designs a unique collection of 1240 pyroptosis-related compounds mainly focusing on the key targets in the pyroptosis signaling pathway and can be used in the research of pyroptosis signal pathway and related diseases.

HY-L175

Inflammasomes related Compound Library

65 compounds

Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response.

MCE designs a unique collection of 65 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Cat. No.	Product Name	Type

HY-P2377

Ac-YVAD-AFC

Dyes

Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm ^[1] .
HY-P1093

Ac-LEHD-AFC

Chromogenic Substrates

Ac-LEHD-AFC is a fluorescent substrate for caspase-9, can be used to assess the activity of caspase .
HY-P2616

Mca-YVADAP-Lys(Dnp)-OH

Chromogenic Substrates

Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P2617A

Ac-WEHD-AFC TFA	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC TFA is a *fluorogenic caspase-1* substrate*. Ac-WEHD-AFC TFA can measure caspase-1* fluorogenic activity and can be used for the research of tumor and inflammation ^[1].

HY-P10084

Ac-VAD-pNA

Caspase Others

Ac-VAD-pNA is a caspase-1 substrate. Ac-VAD-pNA can be used to detect caspase-1 activity ^[1].
HY-P5974

Z-YVAD-pNA

Z-Tyr-Val-Ala-Asp-pNA
Caspase Others

Z-YVAD-pNA (Z-Tyr-Val-Ala-Asp-pNA) is a caspase-1 substrate ^[1].
HY-P5938

Ac-AAVALLPAVLLALLAP-YVAD-CHO

Caspase Cancer

Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable caspase-1 inhibitor that has antitumor activity ^[1].

HY-P2617

Ac-WEHD-AFC	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC is a *fluorogenic caspase-1* substrate*. Ac-WEHD-AFC can measure caspase-1* fluorogenic activity and can be used for the research of tumor and inflammation ^[1].

HY-P2091

Ac-YVAD-pNA	Caspase	Inflammation/Immunology
Ac-YVAD-pNA is a specific *Caspase-1* substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes ^[1] .

HY-P4429

Z-YVAD-AFC

Peptides Others

Z-YVAD-AFC is a fluorescent substrate for Caspase-1, which can be used to detect and measure the activity of Caspase-1 ^[1].
HY-W792412

Z-YVAD-CMK

Caspase Cancer

Z-YVAD-CMK is a caspase-1 and caspase-3 inhibitor ^[1].
HY-136728

Ac-YVAD-AOM

Caspase Cancer

Ac-YVAD-AOM is the inhibitor of caspase-1 that shows antitumor activity ^[1].
HY-P4547

Ac-Trp-Glu-His-Asp-AMC

AC-WEHD-AMC
Caspase Others

Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 ^[1].
HY-P2377

Ac-YVAD-AFC

Fluorescent Dye Others

Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm ^[1] .

HY-P2616

Mca-YVADAP-Lys(Dnp)-OH	Caspase Angiotensin-converting Enzyme (ACE)	Others
Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate for *caspase-1* and angiotensin-converting enzyme 2 (ACE2) ^[1].

HY-P4535

Ac-Trp-Glu-His-Asp-Aldehyde

Caspase Inflammation/Immunology

Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective caspase-1 inhibitor with a K_i value of 56 pM ^[1] .
HY-P2616A

Mca-YVADAP-Lys(Dnp)-OH TFA

Cholinesterase (ChE) Caspase Others

Mca-YVADAP-Lys(Dnp)-OH TFA is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) ^[1].

HY-P5122

Z-LEED-FMK	Caspase	Inflammation/Immunology
Z-LEED-FMK is a *caspase-13* and *caspase-4* inhibitor. Z-LEED-FMK also inhibits caspase-1 processing in S. typhimurium-infected macrophages ^[1] .

HY-P3761

Ac-Tyr-Val-Lys-Asp-aldehyde	Caspase	Others
Ac-Tyr-Val-Lys-Asp-aldehyde is a *caspase-1* inhibitor, can be used for disease research including anemia-associated to chronic diseases, chemotherapy-induced anemia and Diamond-Blackfan anemia ^[1].

HY-120019

Ac-YVAD-CHO L-709049	Interleukin Related Apoptosis Caspase	Inflammation/Immunology
Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human K_i values of 3.0 and 0.76 nM. Ac-YVAD-CHO is also a *caspase-1* inhibitor. Ac-YVAD-CHO can suppress the production of mature IL-lβ ^[1] .

HY-P10142

Ac-YEVD-AMC	Fluorescent Dye	Others
Ac-YEVD-AMC is a fluorescent substrate of *caspase-1/11*. Ac-YEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection when treating with cell lysate ^[1].

HY-P0111

Z-WEHD-FMK 2 Publications Verification Z-WE(OMe)HD(OMe)-FMK	Caspase Cathepsin	Cancer
Z-WEHD-FMK is a potent, cell-permeable and irreversible *caspase-1/5* inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC₅₀=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis ^[1] .

HY-P1009

Z-YVAD-FMK Maximum Cited Publications 13 Publications Verification	Caspase	Cancer
Z-YVAD-FMK is a cell-permeable caspase-1 and -4 inhibitor with anti-inflammatory and anti-tumor activities ^[1].

HY-P5890

YVAD-CHO	Interleukin Related Caspase	Neurological Disease
YVAD-CHO is an interleukin-1β converting enzyme (ICE, caspase 1) inhibitor that can partially delay motoneurone death in lesioned facial nerve mice ^[1].

HY-12290

Arg-Gly-Asp-Ser 5 Publications Verification RGDS peptide; Fibronectin tetrapeptide	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

HY-12290A

Arg-Gly-Asp-Ser TFA RGDS peptide TFA; Fibronectin tetrapeptide TFA	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser (TFA) is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser (TFA) directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1 ^[1].

Recombinant Proteins Recommended:

Caspase-1

Cat. No.	Compare	Product Name	Species	Source

HY-P72117

	Caspase-1/CASP1 Protein, Human (GST) CASP-1; CASP1; CASP1_HUMAN; Caspase 1; ICE; IL-1 beta-converting enzyme; IL-1BC; IL1 beta converting enzyme; IL1B convertase; Interleukin 1 beta convertase; Interleukin 1B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45	Human	E. coli
	Caspase-1/CASP1 is a thiol protease complex involved in inflammation by catalyzing the cleavage of IL1B, IL18, and Gasdermin-D (GSDMD). It activates a pro-inflammatory response, releases mature cytokines IL1B and IL18, and initiates pyroptosis through cleavage of GSDMD. Caspase-1/CASP1 Protein, Human (GST) is the recombinant human-derived Caspase-1/CASP1 protein, expressed by E. coli , with N-GST labeled tag. The total length of Caspase-1/CASP1 Protein, Human (GST) is 150 a.a., with molecular weight of ~43.8 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P80622

*Cleaved-Caspase 1* Antibody** CASP1; IL1BC; IL1BCE; Caspase-1; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45	WB, ICC/IF, IHC-F, IHC-P, ELISA	Human, Mouse
Cleaved-Caspase 1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 45 kDa, targeting to Cleaved-Caspase 1. It can be used for WB,ICC/IF,IHC-F,IHC-P,ELISA assays with tag free, in the background of Human, Mouse.

HY-P81232

Caspase-1 p20 Antibody Caspase-1 isoform alpha p20 subunit; CASP1; ICE; IL1BC; Caspase-1 subunit p20; CASP 1; Caspase 1 apoptosis related cysteine peptidase; Caspase 1 apoptosis related cysteine protease; Caspase1; IL 1 beta converting enzyme; IL 1BC; IL1B convertase; IL1BCE; Interleukin 1 beta convertase; Interleukin 1 beta convertase precursor; Interleukin 1 beta converting enzyme; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45; CASP1_HUMAN; CASP1_MOUSE.	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; ICC; IF	Human, Mouse, Rat,
Caspase-1 p20 Antibody is an unconjugated, approximately 20/46 kDa, rabbit-derived, anti-Caspase-1 p20 polyclonal antibody. Caspase-1 p20 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, ICC, IF expriments in human, mouse, rat, background without labeling.

HY-P80587

Caspase 1 Antibody CASP1; IL1BC; IL1BCE; Caspase-1; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45	WB, IHC-P, ELISA	Human, Mouse, Rat
Caspase 1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 45 kDa, targeting to Caspase 1. It can be used for WB,IHC-P,ELISA assays with tag free, in the background of Human, Mouse, Rat.

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