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Cassia

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Apoptosis (2) Bacterial (1) COX (1) Endogenous Metabolite (2) Glucosidase (2) GLUT (2) HCV (2) HIV (3) Keap1-Nrf2 (1) Monoamine Oxidase (3) NF-κB (1) PDGFR (2) Phosphatase (1) SARS-CoV (1) STAT (1) TNF Receptor (1) Tyrosinase (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Infection (6) Inflammation/Immunology (4) Metabolic Disease (5) Neurological Disease (5)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7628

Cassiaside C Toralactone 9-O-β-D-gentiobioside	Endogenous Metabolite	Metabolic Disease
Cassiaside C (Toralactone 9-O-β-D-gentiobioside) is a naphthopyrone isolated from the seed of Cassia tora and has inhibitory activity on advanced glycation end products (AGE) formation in vitro .

HY-N3546

Cassiachromone

Others Others

Cassiachromone can be isoalted from Cassia siamea .
HY-N10939

Gluco-obtusin

Others Infection Neurological Disease Inflammation/Immunology

Gluco-obtusin is an anthraquinone. Gluco-obtusin can be isolated from the seeds of Cassia obtusifolia .

Cassiachromone	Others	Others
Cassiachromone can be isoalted from Cassia siamea .

Gluco-obtusin	Others	Infection Neurological Disease Inflammation/Immunology
Gluco-obtusin is an anthraquinone. Gluco-obtusin can be isolated from the seeds of Cassia obtusifolia .

HY-N8581

5,5'-Dimethoxysecoisolariciresinol (-)-8,8'-Bisdihydrosiringenin	Others	Others
5,5'-Dimethoxysecoisolariciresinol ((-)-8,8'-Bisdihydrosiringenin) is a lignin. 5,5'-Dimethoxysecoisolariciresinol can be isolated from twigs of Cinnamomum cassia .

HY-N10369

1,2,3,7-Tetrahydroxy-8-methoxy-6-methyl-9,10-anthraquinone	Others	Others
1,2,3,7-Tetrahydroxy-8-methoxy-6-methyl-9,10-anthraquinone is an anthraquinone compound isolated from the seeds of Cassia obtusifolia .

HY-N12006

6,8-Dihydroxy-1,2,7-trimethoxy-3-methylanthraquinone	Glucosidase	Others
6,8-Dihydroxy-1,2,7-trimethoxy-3-methylanthraquinone (compound 1) is an anthraquinone α-glucosidase inhibitor (IC₅₀:185 μM), which can be isolated from Cassia seeds .

HY-N7599

Chrysophanol triglucoside	Phosphatase Glucosidase	Metabolic Disease
Chrysophanol triglucoside is an anthraquinone isolated from Cassia obtusifolia, inhibits protein tyrosine phosphatases 1B (PTP1B) and α-glucosidase with IC₅₀s of 80.17 and 197.06 µM, respectively. Chrysophanol triglucoside has the potential for diabetes research .

HY-N1142

Torachrysone

Nakahalene; Trachrysone; Torachryson
Others Others

Torachrysone (Nakahalene; Trachrysone), a naphthalene, can be isolated from Cassia tora L .
HY-N1972

Sennoside C

Sennoside C is an anthraquinone glycoside, found in leaves and pods of Senna (Cassia angustifolia) .
HY-N1973

Sennoside D

Sennoside D is an anthraquinone glycoside, found in leaves and pods of Senna (Cassia angustifolia) .
HY-N4091

Tinnevellin glucoside

Others Others

Tinnevellin glucoside, a naphthalene glycoside, isolated from Cassia senna leaves and pods .
HY-N12009

1-Desmethylobtusin

Others Others

1-Desmethylobtusin is an anthraquinone compound can be isolated from Cassia obtusifolia L .

Torachrysone Nakahalene; Trachrysone; Torachryson	Others	Others
Torachrysone (Nakahalene; Trachrysone), a naphthalene, can be isolated from Cassia tora L .

Sennoside C
Sennoside C is an anthraquinone glycoside, found in leaves and pods of Senna (Cassia angustifolia) .

Sennoside D
Sennoside D is an anthraquinone glycoside, found in leaves and pods of Senna (Cassia angustifolia) .

Tinnevellin glucoside	Others	Others
Tinnevellin glucoside, a naphthalene glycoside, isolated from Cassia senna leaves and pods .

1-Desmethylobtusin	Others	Others
1-Desmethylobtusin is an anthraquinone compound can be isolated from Cassia obtusifolia L .

HY-N4177

Rubrofusarin gentiobioside	Others	Metabolic Disease
Rubrofusarin gentiobioside is isolated from the seeds of Cassia tora L. Rubrofusarin gentiobioside has a radical scavenging effect .

HY-N7617

Toralactone

Keap1-Nrf2 Cancer

Toralactone, isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism .

Toralactone	Keap1-Nrf2	Cancer
Toralactone, isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism .

HY-N7604

Isorubrofusarin-6-O-β-gentiobioside Isorubrofusarin gentiobioside	Others	Others
Isorubrofusarin-6-O-β-gentiobioside (Isorubrofusarin gentiobioside) is a naphthopyrone glycoside isolated from Cassia obtusifolia Linn seeds .

HY-N4179

Aurantio-obtusin β-D-glucoside Glucoaurantio-obtusin	Others	Metabolic Disease
Aurantio-obtusin β-D-glucoside (Glucoaurantio-obtusin), isolated from Cassiae Semen (seeds of Cassia tora), is a glucoside of aurantio-obtusin .

HY-N9961

2-Hydroxyl emodin-1-methyl ether

Others Others

2-Hydroxyl emodin-1-methyl ether (Compound 5) is an anthraquinone that can be isolated from the seeds of Cassia obtusifolia .

2-Hydroxyl emodin-1-methyl ether	Others	Others
2-Hydroxyl emodin-1-methyl ether (Compound 5) is an anthraquinone that can be isolated from the seeds of Cassia obtusifolia .

HY-N7603

Rubrofusarin triglucoside	Monoamine Oxidase	Neurological Disease
Rubrofusarin triglucoside is a glycoside compound isolated from Cassia obtusifolia Linn seeds. Rubrofusarin triglucoside inhibits human monoamine oxidase A (hMAO-A) with an IC₅₀ of 85.5 μM .

HY-W012531

2-Hydroxycinnamic acid	HIV SARS-CoV Endogenous Metabolite	Infection
2-Hydroxycinnamic acid is isolated from the methanol extract of Cinnamomum cassia. 2-Hydroxycinnamic acid shows inhibitory effects on infection of HIV/SARS-CoV S pseudovirus with an IC₅₀ of 0.3 mM

HY-N11063

Obtusifolin-2-O-glucoside	Tyrosinase	Cancer
Obtusifolin-2-O-glucoside (compound 7) is a Tyrosinase inhibitor (IC₅₀=9.2 μM). Obtusifolin-2-O-glucoside can be isolated from cassia seed .

HY-Y1426

2'-Hydroxyacetophenone o-Hydroxyacetophenone; o-Acetylphenol
2'-Hydroxyacetophenone is found in alcoholic beverages. 2'-Hydroxyacetophenone is present in tomato, cassia, fried beef, rum, whiskey, cocoa, coffee and black tea. 2'-Hydroxyacetophenone is a flavouring ingredient. Building block in chemical synthesis.

HY-N0365R

Sennoside A (Standard)	HIV	Infection
Sennoside A (Standard) is the analytical standard of Sennoside A. This product is intended for research and analytical applications. Sennoside A is an anthraquinone glycoside, found in Senna (Cassia angustifolia) . Sennoside A is a HIV-1 inhibitor effective on HIV-1 replication .

HY-N6936

Sennidin A	HCV Akt GLUT	Infection
Sennidin A, isolated from the leaves of Cassia angustifolia, inhibits HCV NS3 helicase, with an IC₅₀ of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Sennidin A stimulates the glucose incorporation .

HY-N6057

Obtusin	Monoamine Oxidase	Neurological Disease
Obtusin, isolated from Cassia obtusifolia Linn seed, is a highly selective and competitive human monoamine oxidase-A (hMAO-A) inhibitor with an IC₅₀ of 11.12 μM and a K_i of 6.15 μM. Obtusin plays a preventive role in neurodegenerative diseases, especially anxiety and depression .

HY-N0366

Sennoside B 1 Publications Verification	PDGFR	Cancer
Sennoside B is an anthraquinone glycoside, found in large quantities in leaves and pods of Senna (Cassia angustifolia) . Sennoside B can inhibit PDGF-stimulated cell proliferation by binding to PDGF-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway .

HY-N7598

Chrysophanol-1-O-β-gentiobioside	Monoamine Oxidase	Neurological Disease
Chrysophanol-1-O-β-gentiobioside, an anthraquinone glycoside isolated from Cassia obtusifolia seeds. Chrysophanol-1-O-β-gentiobioside shows selective inhibition of hMAO-A isozyme activity (IC₅₀=96.15 μM) .

HY-N3149A

2-Hydroxycinnamaldehyde	Wnt β-catenin STAT Apoptosis	Inflammation/Immunology
2-Hydroxycinnamaldehyde is a phenylpropanoid that can be isolated from the bark of Cinnamomum cassia. 2-Hydroxycinnamaldehyde inhibits Wnt/β-catenin, STAT3 signaling. 2-Hydroxycinnamaldehyde induces cell apoptosis 2-Hydroxycinnamaldehyde has antitumor and anti-inflammation activities .

HY-N2098

Obtusifolin	NF-κB	Cancer
Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway . Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein .

HY-N6935

Sennidin B	HCV Akt GLUT	Infection Metabolic Disease
Sennidin B, a stereoisomer isolated from the leaves of Cassia angustifolia, has lower activity than Sennidin A. Sennidin A inhibits HCV NS3 helicase, with an IC₅₀ of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Sennidin A stimulates the glucose incorporation .

HY-130307

Rubrofusarin	Bacterial	Neurological Disease Inflammation/Immunology Cancer
Rubrofusarin is an orange polyketide pigment from Fusarium graminearum . Rubrofusarin is also an active ingredient of the Cassia species and ameliorates chronic restraint stress (CRS) -induced depressive symptoms through PI3K/Akt signaling. Rubrofusarin has anticancer, antibacterial, and antioxidant effects .

HY-N0261

Aurantio-obtusin 1 Publications Verification	TNF Receptor COX	Cardiovascular Disease Inflammation/Immunology
Aurantio-obtusin is a anthraquinone compound that can be extracted from cassia seed. Aurantio-obtusin has the effects of decreasing blood pressure, decreasing blood lipids and anti-inflammatory.Aurantio-obtusin is an orally active vasodilator. Aurantio-obtusin ameliorates hepatic steatosis through AMPK/ autophagy- and AMPK/TFEB mediated inhibition of lipid accumulation .

HY-N0366R

Sennoside B (Standard)	PDGFR	Cancer
Sennoside B (Standard) is the analytical standard of Sennoside B. This product is intended for research and analytical applications. Sennoside B is an anthraquinone glycoside, found in large quantities in leaves and pods of Senna (Cassia angustifolia) . Sennoside B can inhibit PDGF-stimulated cell proliferation by binding to PDGF-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway .

HY-W046353

2-Methoxycinnamaldehyde o-Methoxycinnamaldehyde	Apoptosis	Cancer
2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) is a natural compound of Cinnamomum cassia, with antitumor activity . 2-Methoxycinnamaldehyde inhibits proliferation and induces apoptosis by mitochondrial membrane potential (ΔΨm) loss, activation of both caspase-3 and caspase-9 . 2-Methoxycinnamaldehyde effectively inhibits platelet-derived growth factor (PDGF)-induced HASMC migration .

HY-N0365

Sennoside A 1 Publications Verification	HIV	Infection
Sennoside A is an anthraquinone glycoside found in senna (Cassia angustifolia). Sennoside A is an HIV-1 inhibitor (IC₅₀=3.8 μM) that inhibits HIV-1 replication. Sennoside A also inhibits HIV-1 reverse transcriptase (RT)-related DNA polymerase (RDDP) and ribonuclease H (Ribonuclease H) with IC₅₀s of 1.9 μM and 5.3 μM, respectively .

Cassiaside C Toralactone 9-O-β-D-gentiobioside	Structural Classification Monophenols Classification of Application Fields Leguminosae Source classification Phenols Metabolic Disease Cassia tora Linn. Plants Disease Research Fields	Endogenous Metabolite
Cassiaside C (Toralactone 9-O-β-D-gentiobioside) is a naphthopyrone isolated from the seed of Cassia tora and has inhibitory activity on advanced glycation end products (AGE) formation in vitro .

Cassiachromone	Seeds of Cassia tora Linn. Structural Classification Monophenols Leguminosae Source classification Phenols Senna siamea (Lamarck) H. S. Irwin & Barneby Plants	Others
Cassiachromone can be isoalted from Cassia siamea .

Gluco-obtusin	Quinones Structural Classification Leguminosae Anthraquinones Source classification Cassia tora Linn. Plants	Others
Gluco-obtusin is an anthraquinone. Gluco-obtusin can be isolated from the seeds of Cassia obtusifolia .

5,5'-Dimethoxysecoisolariciresinol (-)-8,8'-Bisdihydrosiringenin	Structural Classification Cinnamomum cassia (L.) D. Don Source classification Lignans Phenylpropanoids Plants Lauraceae	Others
5,5'-Dimethoxysecoisolariciresinol ((-)-8,8'-Bisdihydrosiringenin) is a lignin. 5,5'-Dimethoxysecoisolariciresinol can be isolated from twigs of Cinnamomum cassia .

1,2,3,7-Tetrahydroxy-8-methoxy-6-methyl-9,10-anthraquinone	Quinones Classification of Application Fields Cassia obtusifolia L. Anthraquinones Source classification Other Diseases Phenols Polyphenols Caesalpiniaceae Plants Disease Research Fields	Others
1,2,3,7-Tetrahydroxy-8-methoxy-6-methyl-9,10-anthraquinone is an anthraquinone compound isolated from the seeds of Cassia obtusifolia .

6,8-Dihydroxy-1,2,7-trimethoxy-3-methylanthraquinone	Quinones Structural Classification Cassia obtusifolia L. Anthraquinones Source classification Caesalpiniaceae Plants	Glucosidase
6,8-Dihydroxy-1,2,7-trimethoxy-3-methylanthraquinone (compound 1) is an anthraquinone α-glucosidase inhibitor (IC₅₀:185 μM), which can be isolated from Cassia seeds .

Chrysophanol triglucoside	Quinones Monophenols Classification of Application Fields Cassia obtusifolia L. Anthraquinones Source classification Phenols Metabolic Disease Caesalpiniaceae Plants Disease Research Fields	Phosphatase Glucosidase
Chrysophanol triglucoside is an anthraquinone isolated from Cassia obtusifolia, inhibits protein tyrosine phosphatases 1B (PTP1B) and α-glucosidase with IC₅₀s of 80.17 and 197.06 µM, respectively. Chrysophanol triglucoside has the potential for diabetes research .

Torachrysone Nakahalene; Trachrysone; Torachryson	Seeds of Cassia tora Linn. Structural Classification Polygonaceae Source classification Reynoutria japonica Houtt. Melia toosendan Sieb. et Zucc. Melia azedarach L. Plants Meliaceae Leguminosae Phenols Polyphenols Scrophulariaceae Picrorhiza scrophulariiflora Pennell	Others
Torachrysone (Nakahalene; Trachrysone), a naphthalene, can be isolated from Cassia tora L .

Tinnevellin glucoside	Monophenols other families Classification of Application Fields Source classification Other Diseases Phenols Plants Disease Research Fields	Others
Tinnevellin glucoside, a naphthalene glycoside, isolated from Cassia senna leaves and pods .

1-Desmethylobtusin	Quinones Structural Classification Cassia obtusifolia L. Anthraquinones Source classification Caesalpiniaceae Plants	Others
1-Desmethylobtusin is an anthraquinone compound can be isolated from Cassia obtusifolia L .

Rubrofusarin gentiobioside	Seeds of Cassia tora Linn. Monophenols other families Classification of Application Fields Leguminosae Source classification Phenols Metabolic Disease Plants Disease Research Fields	Others
Rubrofusarin gentiobioside is isolated from the seeds of Cassia tora L. Rubrofusarin gentiobioside has a radical scavenging effect .

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Inhibitors & Agonists

NaturalProducts

Natural
Products