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Results for "

Cdc20

" in MedChemExpress (MCE) Product Catalog:

By Targets:	APC (4) Autophagy (1) E3 Ligase Ligand-Linker Conjugates (1) Ligands for Target Protein for PROTAC (1) PROTAC Linkers (1) PROTACs (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (8)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Apcin-A	APC Ligands for Target Protein for PROTAC	Cancer
Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Apcin-A interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V (HY-130257) .

Apcin 3 Publications Verification	APC	Cancer
Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin occupes the D-box-binding pocket on the side face of the WD40-domain and can prolong mitosis .

CDC20 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CDC20 Human Pre-designed siRNA Set A contains three designed siRNAs for CDC20 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CDC20 Human Pre-designed siRNA Set A CDC20 Human Pre-designed siRNA Set A

CDC20-IN-1	Autophagy	Cancer
CDC20-IN-1 (Compound E1) is a specific inhibitor of CDC20 and can be used in triple-negative breast cancer research. CDC20-IN-1 can induce autophagy in cancer cells and inhibit MDA-MB-231 cell proliferation, with an IC₅₀ value of 1.43 μM .

CDC20B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CDC20B Human Pre-designed siRNA Set A contains three designed siRNAs for CDC20B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CDC20B Human Pre-designed siRNA Set A CDC20B Human Pre-designed siRNA Set A

M2I-1	Others	Others
M2I-1 is a Mad2 inhibitor targeting the binding of Mad2 to Cdc20, an essential protein-protein interaction (PPI) within the spindle assembly checkpoint (SAC) .

CP5V	PROTACs	Cancer
CP5V is a PROTAC connected by ligands for von Hippel-Lindau and CDK, which specifically degrades *Cdc20* by linking Cdc20 to the VHL/VBC complex for ubiquitination followed by proteasomal degradation. CP5V induces mitotic inhibition and suppresses cancer cell proliferation .

TAME	APC	Cancer
TAME is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME is not cell permeable .

TAME hydrochloride	APC	Cancer
TAME hydrochloride is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME hydrochloride is not cell permeable .

(S,R,S)-AHPC-PEG5-Boc	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-PEG5-Boc is a E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for Cdc20 degrader CP5V .

Bis-PEG5-acid PROTAC Linker 36	PROTAC Linkers	Cancer
Bis-PEG5-acid (PROTAC Linker 36) is a PROTAC linker, which belongs to a polyethylene glycol (PEG) linker. Bis-PEG5-acid (PROTAC Linker 36) can be used in the synthesis of the CP5V. CP5V is a PROTAC, and specifically degrades Cdc20 .

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