Search Result

Results for "

Cdk

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CDK (452) AAK1 (2) Akt (3) AMPK (1) Amyloid-β (1) Anaplastic lymphoma kinase (ALK) (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) Apoptosis (78) Aryl Hydrocarbon Receptor (1) ATM/ATR (2) Aurora Kinase (3) Autophagy (11) Bacterial (2) Bcl-2 Family (3) Bcr-Abl (1) c-Kit (1) c-Met/HGFR (1) c-Myc (2) Calcium Channel (1) CaMK (1) Carbonic Anhydrase (4) Casein Kinase (5) Caspase (5) CFTR (1) Checkpoint Kinase (Chk) (2) Cholinesterase (ChE) (1) CMV (2) COX (1) Cyclin G-associated Kinase (GAK) (4) DAPK (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (3) Drug Metabolite (2) DYRK (2) E3 Ligase Ligand-Linker Conjugates (3) Early 2 Factor (E2F) (1) EGFR (14) Endogenous Metabolite (1) Enterovirus (1) Epigenetic Reader Domain (3) ERK (4) Estrogen Receptor/ERR (1) Ferroptosis (2) FGFR (1) Flavivirus (1) FLT3 (10) Fungal (2) Glutathione Peroxidase (1) GSK-3 (29) HDAC (4) Histone Demethylase (1) HIV (7) HSV (4) IKK (1) Interleukin Related (1) IRE1 (1) Isotope-Labeled Compounds (1) JAK (6) JNK (3) Ligands for Target Protein for PROTAC (9) LIM Kinase (LIMK) (4) Lipoxygenase (1) MAP4K (1) MAPKAPK2 (MK2) (3) MDM-2/p53 (2) MEK (2) Microtubule/Tubulin (1) Mixed Lineage Kinase (2) Molecular Glues (7) mTOR (2) Necroptosis (1) NF-κB (1) p38 MAPK (1) Parasite (3) PARP (2) PDGFR (1) Phosphatase (2) PI3K (5) Pim (2) PKA (1) PKC (4) PKD (1) Polo-like Kinase (PLK) (1) PPAR (3) PROTAC Linkers (1) PROTACs (32) Proton Pump (2) Raf (2) Reactive Oxygen Species (2) Reverse Transcriptase (1) RIP kinase (2) ROS Kinase (1) Salt-inducible Kinase (SIK) (3) SARS-CoV (1) SHP2 (1) Small Interfering RNA (siRNA) (56) SphK (2) Src (4) STAT (5) Tau Protein (1) TOPK (1) Topoisomerase (2) Trk Receptor (1) ULK (2) VEGFR (5) Virus Protease (1) Wee1 (2) Wnt (3) β-catenin (2)
By Research Areas:	Cancer (454) Cardiovascular Disease (3) Infection (15) Inflammation/Immunology (18) Metabolic Disease (10) Neurological Disease (22)
Click Chemistry:	Azide (1) Alkynes (4)

569

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: CDK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W478102

CDK2-IN-13

CDK Cancer

CDK2-IN-13 (Compound 15) is a CDK2 inhibitor with an IC₅₀ of 12 µM. CDK2-IN-13 can be used in research of cancer .
HY-147386

CDK-IN-10

CDK Cancer

CDK-IN-10 (example 54) is a cyclin dependent kinase (CDK) inhibitor that can be used in cancer research .
HY-153336

CDK-IN-12

CDK Cancer

CDK-IN-12 (Example 20) is a CDK Inhibitor. CDK-IN-12 Inhibits CDK4/6 with IC₅₀ values less than 20 nM .

CDK2-IN-13	CDK	Cancer
CDK2-IN-13 (Compound 15) is a *CDK2* inhibitor with an IC₅₀ of 12 µM. CDK2-IN-13 can be used in research of cancer .

CDK-IN-10	CDK	Cancer
CDK-IN-10 (example 54) is a cyclin dependent kinase (CDK) inhibitor that can be used in cancer research .

CDK-IN-12	CDK	Cancer
CDK-IN-12 (Example 20) is a CDK Inhibitor. CDK-IN-12 Inhibits CDK4/6 with IC₅₀ values less than 20 nM .

HY-146253

CDK1/2/4-IN-1	CDK Apoptosis Bcl-2 Family Caspase	Cancer
CDK1/2/4-IN-1 (compound 3a) is a potent *CDK* inhibitor with IC₅₀ values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 arrests cell cycle at G2/M phase and induces apoptosis. CDK1/2/4-IN-1 elevates Bax, caspase-3, P53 levels and decreases Bcl-2 level. CDK1/2/4-IN-1 can be used for cancer research .

HY-157297

CDK-IN-13	CDK	Cancer
CDK-IN-13 (compound 32E) is a potent and selective inhibitor of *CDK12/cyclinK* with an IC₅₀ of 3 nM. CDK-IN-13 inhibits the growth of the HER2-positive breast cancer cell lines .

HY-149819

CDK/HDAC-IN-3	HDAC CDK	Cancer
CDK/HDAC-IN-3 is an orally active HDACs/CDKs dual inhibitor. CDK/HDAC-IN-3 has potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2 and HDAC3 with IC₅₀ values of 98.32 nM, 98.85 nM, 100 nM, 62.12 nM, 93.28nM and 82.87 nM. CDK/HDAC-IN-3 can be used for the acute myeloid leukemia (AML) .

HY-151878

CDK7-IN-20	CDK GSK-3	Metabolic Disease
CDK7-IN-20 is a potent, selective and irreversible *CDK7* (CDK) inhibitor with an IC₅₀ value of 4 nM. CDK7-IN-20 displays >206-fold selectivity for CDK7 over CDK1, CDK2, CDK3, CDK5, CDK6, CDK9 and CDK12 . CDK7-IN-20 has the potential for autosomal dominant polycystic kidney disease (ADPKD) research .

HY-147905

CDK9-IN-18	CDK Apoptosis	Cancer
CDK9-IN-18 is a potent *CDK9* inhibitor. CDK9-IN-18 blocks the phosphorylation function of kinase CDK9. CDK9-IN-18 exhibits both good anticancer activity and low cellular activity. CDK9-IN-18 induces apoptosis.

HY-112626

CDK12-IN-2	CDK	Cancer
CDK12-IN-2 is a potent, selective and nanomolar *CDK12* inhibitor (IC₅₀=52 nM) with good physicochemical properties. CDK12-IN-2 is also a strong CDK13 inhibitor due to CDK13 is the closest homologue of CDK12. CDK12-IN-2 shows excellent kinase selectivity for CDK12 over CDK2, 9, 8, and 7. CDK12-IN-2 inhibits the phosphorylation of Ser2 in the C-terminal domain of RNA polymerase II. CDK12-IN-2 can be used an excellent chemical probe for functional studies of CDK12 .

HY-145655

CDK7-IN-11	CDK	Cancer
CDK7-IN-11 is an orally active *CDK7* inhibitor. CDK7-IN-11 exhibits high CDK7 inhibitory activity with IC₅₀ value of 4.2 nM. CDK7-IN-11 can be effectively used for the research of diseases associated with CDK7 .

HY-153950

CDK7-IN-22

CDK Cancer

CDK7-IN-22 (compound 101) is an CDK7 inhibitor with antitumor activity. CDK7-IN-22 shows selectivity on CDK7 .

CDK7-IN-22	CDK	Cancer
CDK7-IN-22 (compound 101) is an *CDK7* inhibitor with antitumor activity. CDK7-IN-22 shows selectivity on CDK7 .

HY-130001

CDK9-IN-9	CDK	Cancer
CDK9-IN-9 (example 2) is a potent and selective *CDK9* inhibitor with an IC₅₀ of 1.8 nM. CDK9-IN-9 inhibits CDK2 with an IC₅₀ of 155 nM. CDK9-IN-9 has anti-cancer activity .

HY-151984

CDK9-IN-22	CDK	Cancer
CDK9-IN-22 is a potent *CDK9* inhibitor with IC₅₀s of 10.4, 876.2 nM for CDK9, CDK, respectively. CDK9-IN-22 induces apoptosis and cell cycle arrests at G2/M phase. CDK9-IN-22 decreases the expression of p-RNAPII (S2) and CDK9 protein. CDK9-IN-22 shows antiproliferative and aiti-tumor activity .

HY-145394

CDK7-IN-6	CDK	Cancer
CDK7-IN-6 is a potent and selective cyclin-dependent kinase (CDK7) inhibitor (IC₅₀≤100 nM), extracted from patent WO2019197549 A1, compound 210. CDK7-IN-6 is > 200-fold selective for CDK7 over CDK1, CDK2, and CDK5. CDK7-IN-6 can be used for the research of cancer .

HY-151409

CDK1-IN-5	CDK	Cancer
CDK1-IN-5 (10h) is a selective *CDK1* inhibitor with IC₅₀s of 42.19, 188.71 and 354.15 nM for CDK1, CDK2 and CDK5, respectively. CDK1-IN-5 inhibits growth of cancer cells by affecting cell cycle. CDK1-IN-5 can be used for the research of cancer .

HY-151407

CDK1-IN-3	CDK	Cancer
CDK1-IN-3 (8g) is a selective *CDK1* inhibitor with IC₅₀s of 36.8, 305.17 and 369.37 nM for CDK1, CDK2 and CDK5, respectively. CDK1-IN-3 inhibits the growth of cancer cells by affecting cell cycle. CDK1-IN-3 can be used for the research of cancer .

HY-P2559

CDK7/9 tide

CDK Cancer

CDK7/9 tide is peptide substrate for CDK7 or CDK9 .

CDK7/9 tide	CDK	Cancer
CDK7/9 tide is peptide substrate for CDK7 or CDK9 .

HY-144810

CDK2-IN-8	CDK	Cancer
CDK2-IN-8 is a potent *CDK2* inhibitor with an IC₅₀ of 1.74 µM. CDK2-IN-8 shows antiproliferative activity. CDK2-IN-8 has the potential for the research of melanoma .

HY-151408

CDK1-IN-4	CDK	Cancer
CDK1-IN-4 (10d) is a selective *CDK1* inhibitor with IC₅₀s of 44.52, 624.93 and 135.22 nM for CDK1, CDK2 and CDK5, respectively. CDK1-IN4 inhibits the growth of cancer cells by affecting cell cycle. CDK1-IN-4 can be used for the research of cancer .

HY-130852

CDK9-IN-11

CDK Ligands for Target Protein for PROTAC Cancer

CDK9-IN-11 is a potent CDK9 inhibitor. CDK9-IN-11 is the ligand for the PROTAC CDK9 Degrader-1 (HY-103628) .
HY-130850

CDK9-IN-10

CDK Ligands for Target Protein for PROTAC Cancer

CDK9-IN-10 is a potent CDK9 inhibitor. CDK9-IN-10 is the ligand for the PROTAC CDK9 degrader-2 (HY-112811) .
HY-145693

CDK5-IN-2

CDK Others

CDK5-IN-2 (compound 15) is a highly selective CDK5 inhibitor with IC₅₀s of 0.2 and 23 for CDK5/p25 and CDK2/CycA, respectively .
HY-160643

CDK2-IN-27

CDK Cancer

CDK2-IN-27 (compound 1) is a potent CDK2 inhibitor with IC₅₀ values of <10, >10-20 nM for CDK2/cyclin E1, CDK2/cyclin B1, respectively .
HY-139725

CDK5-IN-1

CDK Metabolic Disease

CDK5-IN-1, a potent CDK5 inhibitor, is against CDK5 activity less than 10 nM. CDK5-IN-1 is used for kidney diseases research .

CDK9-IN-11	CDK Ligands for Target Protein for PROTAC	Cancer
CDK9-IN-11 is a potent *CDK9* inhibitor. CDK9-IN-11 is the ligand for the PROTAC CDK9 Degrader-1 (HY-103628) .

CDK9-IN-10	CDK Ligands for Target Protein for PROTAC	Cancer
CDK9-IN-10 is a potent *CDK9* inhibitor. CDK9-IN-10 is the ligand for the PROTAC CDK9 degrader-2 (HY-112811) .

CDK5-IN-2	CDK	Others
CDK5-IN-2 (compound 15) is a highly selective *CDK5* inhibitor with IC₅₀s of 0.2 and 23 for CDK5/p25 and CDK2/CycA, respectively .

CDK2-IN-27	CDK	Cancer
CDK2-IN-27 (compound 1) is a potent *CDK2* inhibitor with IC₅₀ values of <10, >10-20 nM for CDK2/cyclin E1, CDK2/cyclin B1, respectively .

CDK5-IN-1	CDK	Metabolic Disease
CDK5-IN-1, a potent *CDK5* inhibitor, is against CDK5 activity less than 10 nM. CDK5-IN-1 is used for kidney diseases research .

HY-145694

CDK5-IN-3	CDK	Metabolic Disease
CDK5-IN-3 (compound 11) is a potent and selective *CDK5* inhibitor, with IC₅₀s of 0.6 nM and 18 nM for *CDK5/p25* and *CDK2/CycA, respectively. CDK*5-IN-3 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD) .

HY-150641

CDK-IN-9	CDK Apoptosis DNA/RNA Synthesis	Cancer
CDK-IN-9 (compound 24) is a potent *CDK* inhibitor, also as a molecular glue inducing an interaction between CDK12 and DDB1, with an IC₅₀ values of 4 nM for CDK2/E. CDK-IN-9 leads to polyubiquitination of cyclin K and its subsequent degradation. CDK-IN-9 induce apoptosis through dephosphorylation of retinoblastoma protein and RNA polymerase II .

HY-13033

CDK-IN-2

1 Publications Verification

Cdk inhibitor II
CDK Cancer

CDK-IN-2 is a potent and specific CDK9 inhibitor with IC50 of <8 nM, extracted from reference 1, example 4.

CDK-IN-2 1 Publications Verification Cdk inhibitor II	CDK	Cancer
CDK-IN-2 is a potent and specific CDK9 inhibitor with IC50 of <8 nM, extracted from reference 1, example 4.

HY-144811

CDK2-IN-9	CDK Apoptosis	Cancer
CDK2-IN-9 is a potent *CDK2* inhibitor with an IC₅₀ of 0.63 µM. CDK2-IN-9 shows antiproliferative activity. CDK2-IN-9 induces apoptosis and cell cycle arrest at S and G2/M phase. CDK2-IN-9 has the potential for the research of melanoma .

HY-126244

CDK4/6-IN-3	CDK	Cancer
CDK4/6-IN-3 is a brain-penetrant *CDK4/CDK6* inhibitor with K_is of <0.3 nM and 2.2 nM, respectively. CDK4/6-IN-3 inhibits CDK1 with a K_i of 110 nM. CDK4/6-IN-3 can be used for the treatment of glioblastoma .

HY-126251

CDK9-IN-7	CDK Apoptosis	Cancer
CDK9-IN-7 (compound 21e) is a selective, highly potent, and orally active CDK9/cyclin T inhibitor (IC₅₀=11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD=148 nM; CDK6/cyclinD=145 nM). CDK9-IN-7 shows antitumor activity without obvious toxicity. CDK9-IN-7 induces NSCLC cell apoptosis, arrests the cell cycle in the G2 phase, and suppresses the stemness properties of NSCLC .

HY-151463

CDK8-IN-11	CDK β-catenin	Cancer
CDK8-IN-11 is a potent and selective *CDK8* inhibitor with an IC₅₀ value of 46 nM. CDK8-IN-11 inhibits WNT/β-catenin signaling pathway. CDK8-IN-11 can be used in the research of colon cancer .

HY-151463A

CDK8-IN-11 hydrochloride	CDK β-catenin	Cancer
CDK8-IN-11 hydrochloride is a potent and selective *CDK8* inhibitor with an IC₅₀ value of 46 nM. CDK8-IN-11 hydrochloride inhibits WNT/β-catenin signaling pathway. CDK8-IN-11 hydrochloride can be used in the research of colon cancer .

HY-115924

CDK1-IN-1	CDK	Cancer
CDK1-IN-1 is a potent *CDK1* inhibitor (CDK1/CycB IC₅₀=161.2 nM) with potential antiproliferative activity and selectivity for cancer tissues. CDK1-IN-1 induces apoptosis in p53 dependent manner through the intrinsic apoptotic pathway. CDK1-IN-1 is a potential targeted antitumor agent .

HY-149974

CDK8-IN-13	Apoptosis CDK	Cancer
CDK8-IN-13 is a potent, selective and orally active *CDK8* inhibitor with an IC₅₀ value of 51.9 nM. CDK8-IN-13 induces Apoptosis. CDK8-IN-13 decreases the expression of p-STAT1 S727 and p-STAT5 S726. CDK8-IN-13 shows antitumor activity .

HY-162255

CDK2-IN-23	CDK	Cancer
CDK2-IN-23 (Compound 17) is a kinase selective and highly potent *CDK2* inhibitor (IC₅₀ = 0.29 nM). CDK2-IN-23 shows the pharmacodynamic inhibition of CDK2 in CCNE1-amplified mouse models. CDK2-IN-23 can be used for the research of cancer .

HY-139328

CDK12-IN-5	CDK	Cancer
CDK12-IN-5, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC₅₀ of 23.9 nM at high ATP (2 mM). CDK12-IN-5 has no effect on CDK2/Cyclin E (IC₅₀=173 μM) and CDK9/Cyclin T1 (IC₅₀=127 μM) at high ATP (2 mM) (WO2021116178A1) .

HY-144175

CDK7-IN-12	CDK	Cancer
CDK7-IN-12 is a potent inhibitor of *CDK7. CDK7-IN-12 plays a key role in transcriptional regulation and cell cycle regulation. CDK7-IN-12 effectively inhibit malignant tumor proliferation in vitro and in vivo. CDK*7-IN-12 has the potential for the research of cancer disease (extracted from patent WO2021249417A1, compound 43) .

HY-151580

CDK2-IN-14

CDK Cancer

CDK2-IN-14 (compound 4f) is a highly selective CDK2 inhibitor. CDK2-IN-14 can be used in research of cancer .

CDK2-IN-14	CDK	Cancer
CDK2-IN-14 (compound 4f) is a highly selective *CDK2* inhibitor. CDK2-IN-14 can be used in research of cancer .

HY-117535

CDK2-IN-4 2 Publications Verification	CDK	Cancer
CDK2-IN-4 (compound 73) is a potent and selective *CDK2* inhibitor with an IC₅₀ of 44 nM for CDK2/cyclin A, shows 2,000-fold selectivity over CDK1/cyclin B (IC₅₀=86 uM) .

HY-147527

CDK8-IN-5	CDK	Inflammation/Immunology
CDK8-IN-5 is a potent *CDK8* inhibitor with an IC₅₀ of 72 nM. CDK8-IN-5 shows anti-inflammatory activities with 43% IL-10 enhancement rate. CDK8-IN-5 has the potential for the research of inflammatory bowel disease .

HY-153088

CDK4/6-IN-16	CDK	Cancer
CDK4/6-IN-16 (example 195) is a potent *CDK4* and *CDK6* inhibitor, with an IC₅₀ of 0.013 μM for *CDK4. CDK4/6-IN-16 can be used for the research of CDK*4-mediated disorders, such as cancer .

HY-136711

CDK7-IN-2 hydrochloride hydrate

CDK Cancer

CDK7-IN-2 hydrochloride hydrate (Example 6) is a potent and selective CDK7 inhibitor. CDK7-IN-2 has potent anti-cancer activity .
HY-148651

CDK2-IN-15

CDK Cardiovascular Disease Cancer

CDK2-IN-15 (Compound 19) is an inhibitor of CDK2 with an IC₅₀ of 2.9 μM. CDK2-IN-15 can be used for cancer research .

CDK7-IN-2 hydrochloride hydrate	CDK	Cancer
CDK7-IN-2 hydrochloride hydrate (Example 6) is a potent and selective *CDK7* inhibitor. CDK7-IN-2 has potent anti-cancer activity .

CDK2-IN-15	CDK	Cardiovascular Disease Cancer
CDK2-IN-15 (Compound 19) is an inhibitor of *CDK2* with an IC₅₀ of 2.9 μM. CDK2-IN-15 can be used for cancer research .

HY-147597

CDK7-IN-13	CDK	Cancer
CDK7-IN-13 is a potent inhibitor of *CDK7. CDK7-IN-13 is a pyrimidinyl derivative compound. CDK*7-IN-13 has the potential for the research of various cancers, especially the cancer with transcriptional dysregulation (extracted from patent CN114249712A, compound 1) .

HY-147600

CDK7-IN-15	CDK	Cancer
CDK7-IN-15 is a potent inhibitor of *CDK7. CDK7-IN-15 is a pyrimidinyl derivative compound. CDK*7-IN-15 has the potential for the research of various cancers, especially the cancer with transcriptional dysregulation (extracted from patent CN114249712A, compound 8) .

HY-147602

CDK7-IN-17	CDK	Cancer
CDK7-IN-17 is a potent inhibitor of *CDK7. CDK7-IN-17 is a pyrimidinyl derivative compound. CDK*7-IN-17 has the potential for the research of various cancers, especially the cancer with transcriptional dysregulation (extracted from patent CN114249712A, compound 1) .

HY-147603

CDK7-IN-18	CDK	Cancer
CDK7-IN-18 is a potent inhibitor of *CDK7. CDK7-IN-18 is a pyrimidinyl derivative compound. CDK*7-IN-18 has the potential for the research of various cancers, especially the cancer with transcriptional dysregulation (extracted from patent CN114249712A, compound 15) .

HY-147598

CDK7-IN-14	CDK	Cancer
CDK7-IN-14 is a potent inhibitor of *CDK7. CDK7-IN-14 is a pyrimidinyl derivative compound. CDK*7-IN-14 has the potential for the research of various cancers, especially the cancer with transcriptional dysregulation (extracted from patent CN114249712A, compound 3) .

HY-139327

CDK12-IN-4	CDK	Cancer
CDK12-IN-4, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC₅₀ of 0.641 μM at high ATP (2 mM). CDK12-IN-4 has no effect on CDK2/Cyclin E (IC₅₀>20 μM) and CDK9/Cyclin T1 (IC₅₀>20 μM) at high ATP (2 mM) (WO2021116178A1) .

HY-139329

CDK12-IN-6	CDK	Cancer
CDK12-IN-6, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC₅₀ of 1.19 μM at high ATP (2 mM). CDK12-IN-6 has no effect on CDK2/Cyclin E (IC₅₀>20 μM) and CDK9/Cyclin T1 (IC₅₀>20 μM) at high ATP (2 mM) (WO2021116178A1) .

Cat. No.	Product Name

HY-L009

Kinase Inhibitor Library

3103 compounds

Kinase is an enzyme that adds phosphate groups to other molecules. This process is known as phosphorylation. Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and so on. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinases are a large group of drug targets in drug discovery. Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders.

Kinase inhibitor library designed by MCE contains 3103 kinase inhibitors and regulators mainly targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.) and carbohydrate kinases (Hexokinase), and is a useful tool for kinase drug discovery and related research.

HY-L004

Cell Cycle/DNA Damage Compound Library

1995 compounds

DNA is prone to numerous forms of damage that can injure cells and impair fitness. Cells have developed an array of mechanisms to repair these injuries. Proliferating cells are especially vulnerable to DNA damage due to the added demands of cellular growth and division. Cell cycle checkpoints represent integral components of DNA repair that coordinate cooperation between the machinery of the cell cycle and several biochemical pathways that respond to damage and restore DNA structure. By delaying progression through the cell cycle, checkpoints provide more time for repair before the critical phases of DNA replication, when the genome is replicated, and of mitosis, when the genome is segregated. Loss or attenuation of checkpoint function may increase spontaneous and induced gene mutations and chromosomal aberrations by reducing the efficiency of DNA repair.

MCE owns a unique collection of 1995 cell cycle/DNA damage-related compounds which can be used in the research of the same.

Cat. No.	Product Name	Target	Research Area

HY-P2559

CDK7/9 tide

CDK Cancer

CDK7/9 tide is peptide substrate for CDK7 or CDK9 .

HY-P0235

CDK2	Peptides	Cancer
CDK2 is a member of the eukaryotic S/T protein kinase family and its function is to catalyze the phosphoryl transfer of ATP γ-phosphate to serine or threonine hydroxyl (denoted as S₀/T₀) in a protein substrate.

HY-P3730

Cdk2/Cyclin Inhibitory Peptide I

CDK Cancer

Cdk2/Cyclin Inhibitory Peptide I (Tat-LFG), a CDK2 inhibitor, kills U2OS osteosarcoma cells in a dose-dependent manner .
HY-P2668

Cdk5 Substrate

Peptides Others

Cdk5 Substrate is a biological active peptide. (substrate for the cdc2 protein kinase)

HY-P1906

*[pThr3]-CDK5 Substrate*	CDK	Neurological Disease
[pThr3]-CDK5 Substrate is an effective Phospho-Thr3CDK5 Substrate. [pThr3]-CDK5 Substrate is derived from the sequence of the histone H1 peptide that docks in the active site of CDK5. [pThr3]-CDK5 Substrate is phosphorylated by CDK5 with a K_m value of 6 µM .

HY-P1906A

*[pThr3]-CDK5 Substrate TFA*	CDK	Neurological Disease
[pThr3]-CDK5 Substrate TFA is an effective Phospho-Thr3CDK5 Substrate. [pThr3]-CDK5 Substrate is derived from the sequence of the histone H1 peptide that docks in the active site of CDK5. [pThr3]-CDK5 Substrate is phosphorylated by CDK5 with a K_m value of 6 µM .

HY-P2480

Histone H1-derived Peptide	Peptides	Others
Histone H1-derived Peptide is a phosphopeptide and the peptide substrates containes a sequence in accordance with the optimal recognition motif for CDKs .

HY-P5428

Cdc2 kinase substrate	Peptides	Others
Cdc2 kinase substrate is a biological active peptide. (The native peptide HATPPKKKRK is a substrate for cyclin-dependent protein kinase 1 (CDC2; CDK1).)

HY-P1933

[pSer2, pSer5, pSer7]-CTD	Peptides	Cancer
[pSer2, pSer5, pSer7]-CTD, a substrate for CDK7 (cyclin dependent protein kinase), is a phosphorylated polypeptide at ser2, ser5 and ser7 sites of RNA polymerase II carboxy-terminal domain (CTD) .

HY-P1933A

[pSer2, pSer5, pSer7]-CTD TFA	CDK	Cancer
[pSer2, pSer5, pSer7]-CTD (TFA), a substrate for CDK7 (cyclin dependent protein kinase), is a phosphorylated polypeptide at ser2, ser5 and ser7 sites of RNA polymerase II carboxy-terminal domain (CTD) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-116035

Nimbolide 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Azadirachta indica A. Juss. Disease Research Fields Meliaceae Cancer	NF-κB CDK Apoptosis
Nimbolide is a triterpene compound that can be isolated from neem (Azadirachta indica), possesses anticancer and antiproliferative activity. Nimbolide induces tumor cell apoptosis by inhibiting NF-κB and *CDK4/CDK6* kinase. Nimbolide suppresses the Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways .

HY-103248

Toyocamycin 4 Publications Verification Vengicide	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	IRE1 Fungal Antibiotic Apoptosis CDK
Toyocamycin (Vengicide) is an adenosine analog produced by Streptomyces diastatochromogenes, acts as an XBP1 inhibitor. Toyocamycin blocks RNA synthesis and ribosome function, and induces apoptosis. Toyocamycin affects IRE1α-XBP1 pathway, and inhibits XBP1 mRNA cleavage with an IC₅₀ value of 80 nM with affecting IRE1α auto-phosphorylation. Toyocamycin specifically inhibits *CDK9* with an IC₅₀ value of 79 nM .

HY-W010128

6-(Dimethylamino)purine 6-Dimethylaminopurine	Classification of Application Fields Other Diseases Disease Research Fields	CDK
6-(Dimethylamino)purine is a dual inhibitor of protein kinase and *CDK* .

HY-149436

CDK2/Bcl2-IN-1	Structural Classification Terpenoids Zygophyllaceae Source classification Diterpenoids Plants Zygophyllum album L.f.	CDK
CDK2/Bcl2-IN-1 (compound 1), a saponin and a CDK-2 inhibitor (IC₅₀=117.6 nM) with promising cytotoxicity against cancer cells. CDK2/Bcl2-IN-1 also inhibits Bcl-2, and induces apoptosis in A549 lung cancer cells .

HY-N9561

Vanicoside B	Structural Classification Polygonaceae Source classification Phenols Polyphenols Plants Perilla ocimoides L.	CDK STAT
Vanicoside B is a phenylpropanoyl sucrose derivative, can be isolated from the herb Persicaria dissitiflora. Vanicoside B targets cyclin-dependent kinase 8 (CDK8) and exhibits anti-tumor activity. The potential mechanism is Vanicoside B blocks *CDK8*-mediated signaling pathways and decreases the expression of epithelial-mesenchymal transition proteins, so that it leads to cell cycle arrest and apoptosis .

HY-N5072

Desmethylglycitein 4',6,7-Trihydroxyisoflavone	Flavonoids Classification of Application Fields Leguminosae Glycine max (L.) merr Source classification Phenols Polyphenols Plants Disease Research Fields Isoflavones Cancer	CDK PI3K PKC
Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to *CDK1* and *CDK2* in vivo, resulting in the suppresses CDK1 and CDK2 activity . Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1) . Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes .

HY-N0400

Wogonin Maximum Cited Publications 13 Publications Verification	Flavonoids Scutellaria baicalensis Georgi Classification of Application Fields Flavones Labiatae Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	CDK Wnt Autophagy Apoptosis
Wogonin is a naturally occurring mono-flavonoid, can inhibit the activity of *CDK8* and Wnt, and exhibits anti-inflammatory and anti-tumor effects.

HY-103382

Arcyriaflavin A	Infection Alkaloids Structural Classification Microorganisms Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids	Fungal
Arcyriaflavin A is a fungal metabolite obtained from the fungi, Nocardiopsis. Arcyriaflavin A is an inhibitor of CDK4 (IC₅₀ = 140 nM) and CaMKII (IC₅₀ = 25 nM) .

HY-N3634

Corylifol C	Structural Classification Leguminosae Source classification Phenols Polyphenols Psoralea corylifolia L. Plants	Others
Corylifol C is a potent protein kinase inhibitor with IC₅₀ valueS of 8.7, 3.0, 2.1, 6.4, 4.5, 6.2, 2.3, 1.2, 5.1 μg/ml for ARK5, Aurora-A, Aurora-B, AXL, B-RAF-VE, CDK4/CycD1, TIE2, EGF-R, EPHB4, respectively .

HY-W077292

2,4,6-Trihydroxybenzoic acid	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Cancer	CDK
2,4,6-Trihydroxybenzoic acid, the flavonoid metabolite, is a *CDK* inhibitor. 2,4,6-Trihydroxybenzoic acid can be used for the research of cancer .

HY-117025A

Manzamine A hydrochloride 1 Publications Verification Keramamine A hydrochloride	Structural Classification Neurological Disease Classification of Application Fields Source classification Marine natural products Pyridine Alkaloids Indole Alkaloids Infection Alkaloids Piperidine Alkaloids Animals Sponge Disease Research Fields	GSK-3 CDK Parasite Proton Pump HSV Autophagy
Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and *CDK-5* with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1 .

HY-117025

Manzamine A Keramamine A	Infection Alkaloids Structural Classification Neurological Disease Classification of Application Fields Animals Marine natural products Sponge Disease Research Fields Cancer	GSK-3 CDK Parasite Proton Pump HSV Autophagy
Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and *CDK-5* with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against HSV-1 .

HY-N0400R

Wogonin (Standard)	Structural Classification Flavonoids Scutellaria baicalensis Georgi Classification of Application Fields Labiatae Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	CDK Wnt Autophagy Apoptosis
Wogonin (Standard) is the analytical standard of Wogonin. This product is intended for research and analytical applications. Wogonin is a naturally occurring mono-flavonoid, can inhibit the activity of *CDK8* and Wnt, and exhibits anti-inflammatory and anti-tumor effects.

HY-N11774

Euphornin	Structural Classification Natural Products Source classification Euphorbia helioscopia L. Euphorbiaceae Plants	Apoptosis Caspase
Euphornin is a anticaner agent, that can be isolated from E. helioscopia. Euphornin induces apoptosis via caspase-mediated pathways. Euphornin induces cell cycle arrest by increasing the level of the phospho-CDK1 (Tyr15) protein .

HY-N1127

Tricin 1 Publications Verification	Infection Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Agrostidoideae Phenols Polyphenols Plants Disease Research Fields Triticum aestivum L.	CMV
Tricin is a natural flavonoid found in large amounts in wheat. Tricin inhibits HCMV replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells by upregulating the expression of FAK-targeting microRNA-7 .

HY-N0636

Eriocitrin 1 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Citrus limon (L.) Burm. F. Flavonones Source classification Rutaceae Phenols Polyphenols Plants Disease Research Fields Cancer	Apoptosis
Eriocitrin is a flavonoid isolated from lemons that is a powerful antioxidant. Eriocitrin inhibits the proliferation of liver cancer cells by arresting the cell cycle in the S phase by upregulating p53, cyclin A, cyclin D3 and CDK6. Eriocitrin triggers apoptosis by activating intrinsic signaling pathways involving mitochondria .

HY-N11439

Albanol B	Structural Classification Natural Products Source classification Phenols Polyphenols Morus alba L. Plants Moraceae	CDK Akt ERK Apoptosis Bacterial
Albanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities. Albanol B inhibits cancer cells proliferation, down-regulates *CDK1* expression. Albanol B also induces cell cycle arrest at G2/M and apoptosis. And Albanol B induces mitochondrial ROS production and increases the phosphorylation levels of AKT and ERK1/2 .

HY-W019806

Lacto-N-fucopentaose I LNFP I	Infection Structural Classification Natural Products Polysaccharides Classification of Application Fields Animals Inflammation/Immunology Disease Research Fields Saccharides	Endogenous Metabolite CDK Reactive Oxygen Species Apoptosis Enterovirus Bacterial
Lacto-N-fucopentaose I (LNFPI) is a human milk oligosaccharide (HMO), possessing antiviral and antibacterial activity. Lacto-N-fucopentaose I can reduce capsid protein VP1 to block virus adsorption, promote *CDK2* and reduce cyclin E to recover cell cycle S phase block. Lacto-N-fucopentaose I inhibits ROS production and apoptosis in virus-infected cells. Lacto-N-fucopentaose I can also regulate intestinal microbiota to affect immune system development .

HY-N6954

Garcinone C 1 Publications Verification	Structural Classification other families Xanthones Classification of Application Fields Garcinia oblongifolia Champ. ex Benth. Source classification Guttiferae Phenols Polyphenols Plants Disease Research Fields Cancer	ATM/ATR STAT CDK
Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while efficiently inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, cdc2, Stat3 and *CDK7*. Garcinone C significantly inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner .

Species:	Human (62) Mouse (1)
Tag:	His (38) SUMO (1) Tag Free (14) GST (41) Flag (30)
Source:	HEK293 (1) P. pastoris (1) Sf9 insect cells (56) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P72298

	CDK5 Protein, Human (P.pastoris, His) Cdk5; Cell division protein kinase 5; Protein kinase Cdk5 splicing; PSSALRE	Human	P. pastoris
	CDK5 is a proline-directed serine/threonine protein kinase that critically regulates neuronal cell cycle, differentiation and potential apoptosis in neuronal diseases by preventing cell cycle re-entry. It interacts with numerous proteins involved in neuronal development and coordinates processes such as survival, migration, differentiation, axonal growth, synaptogenesis, and neurotransmission. CDK5 Protein, Human (P.pastoris, His) is the recombinant human-derived CDK5 protein, expressed by P. pastoris , with N-His labeled tag. The total length of CDK5 Protein, Human (P.pastoris, His) is 292 a.a., with molecular weight of ~38.0 kDa.

HY-P700569

	CDK4 Protein, Human (Baculovirus, His) Cdk4; Cell division protein kinase 4; CMM3; PSK-J3	Human	Sf9 insect cells
	CDK4 protein, acting as a Ser/Thr kinase in the cyclin D-CDK4 complex, critically regulates the G(1)/S transition by phosphorylating and inhibiting RB family members. This activity, specifically hypophosphorylation of RB1 during early G(1) phase, releases E2F and promotes transcription of genes that drive G(1) progression. CDK4 Protein, Human (Baculovirus, His) is the recombinant human-derived CDK4 protein, expressed by Sf9 insect cells , with N-6*His labeled tag. The total length of CDK4 Protein, Human (Baculovirus, His) is 302 a.a., with molecular weight of 35.6 kDa.

HY-P70014

	CDK2 Protein, Human (His) rHuCyclin-dependent kinase 2/Cdk2, His; Cyclin-Dependent Kinase 2; Cell Division Protein Kinase 2; p33 Protein Kinase; Cdk2; CdkN2	Human	E. coli
	CDK2 is an important serine/threonine protein kinase that plays a critical regulatory role in the cell cycle, especially during meiosis. It phosphorylates various substrates (CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2) and coordinates centrosome duplication and initiation of DNA synthesis at the G1-S transition. CDK2 Protein, Human (His) is the recombinant human-derived CDK2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CDK2 Protein, Human (His) is 298 a.a., with molecular weight of 32-35 kDa.

HY-P70014A

	CDK2 Protein, Human (N-His) rHuCyclin-dependent kinase 2/Cdk2, His; Cyclin-Dependent Kinase 2; Cell Division Protein Kinase 2; p33 Protein Kinase; Cdk2; CdkN2	Human	E. coli
	CDK2 is an important serine/threonine protein kinase that plays a critical regulatory role in the cell cycle, especially during meiosis. It phosphorylates various substrates (CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2) and coordinates centrosome duplication and initiation of DNA synthesis at the G1-S transition. CDK2 Protein, Human (N-His) is the recombinant human-derived CDK2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CDK2 Protein, Human (N-His) is 297 a.a., with molecular weight of approximately 32.65 kDa.

HY-P7850

	CDK2AP2 Protein, Human (HEK293, His) rHuCyclin-dependent kinase 2-associated protein 2/Cdk2AP2, His; Cyclin-dependent kinase 2-associated protein 2; Cdk2-associated protein 2; DOC-1-related protein; DOC-1R; Cdk2AP2; DOC1R	Human	HEK293
	CDK2AP2 protein, a vital component of the NuRD complex, actively engages in chromatin remodeling. It inhibits G1/S phase transition by suppressing CDK2, impeding CDK2's interaction with cyclin E or A. Beyond cell cycle control, CDK2AP2 is crucial for ESC self-renewal, ensuring survival during differentiation, and regulates microtubule organization in metaphase II oocytes. Part of the NuRD complex, CDK2AP2 collaborates with proteins like MTA1, MTA2, HDAC1, and others, showcasing its multifaceted regulatory functions. CDK2AP2 Protein, Human (HEK293, His) is the recombinant human-derived CDK2AP2 protein, expressed by HEK293, with C-6*His labeled tag. The total length of CDK2AP2 Protein, Human (HEK293, His) is 126 a.a., with molecular weight of ~26.0 kDa.

HY-P702675

	CDK2-CCNA2 Protein, Human (sf9, GST, His) Cdk2; cyclin-dependent kinase 2; p33 protein kinase; cell devision kinase 2; cdc2-related protein kinase; cell division protein kinase 2; p33(Cdk2)	Human	Sf9 insect cells

HY-P702676

	CDK2-CCND1 Protein, Human (sf9, GST, Flag, His) Cdk2; cyclin-dependent kinase 2; p33 protein kinase; cell devision kinase 2; cdc2-related protein kinase; cell division protein kinase 2; p33(Cdk2)	Human	Sf9 insect cells

HY-P702677

	CDK2-CCNE1 Protein, Human (sf9, GST, His, Flag) Cdk2; cyclin-dependent kinase 2; p33 protein kinase; cell devision kinase 2; cdc2-related protein kinase; cell division protein kinase 2; p33(Cdk2)	Human	Sf9 insect cells

HY-P702678

	CDK2-CCNE2 Protein, Human (sf9, GST, Flag, His) Cdk2; cyclin-dependent kinase 2; p33 protein kinase; cell devision kinase 2; cdc2-related protein kinase; cell division protein kinase 2; p33(Cdk2)	Human	Sf9 insect cells

HY-P702679

	CDK2-CCNO Protein, Human (sf9, GST, Flag, His) Cdk2; cyclin-dependent kinase 2; p33 protein kinase; cell devision kinase 2; cdc2-related protein kinase; cell division protein kinase 2; p33(Cdk2)	Human	Sf9 insect cells

HY-P702685

	CDK5-p25 Protein, Human (sf9, GST, His, Flag) Cdk5; cyclin-dependent kinase 5; PSSALRE; TPKII catalytic subunit; protein kinase Cdk5 splicing; cell division protein kinase 5; serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit	Human	Sf9 insect cells

HY-P702686

	CDK5-p35 Protein, Human (sf9, GST, His, Flag) Cdk5; cyclin-dependent kinase 5; PSSALRE; TPKII catalytic subunit; protein kinase Cdk5 splicing; cell division protein kinase 5; serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit	Human	Sf9 insect cells

HY-P74257

	CDK1-CCNE1 Heterodimer Protein, Human (sf9, His-GST) Cyclin-dependent kinase 1; Cdk1; CDC2; G1/S-specific cyclin-E1; CCNE1	Human	Sf9 insect cells
	The FGF-9 protein undergoes autoproteolysis and cholesterol attachment in the endoplasmic reticulum. It acts as a morphogen during development, inducing ventral cell fate, participating in limb bud patterning, and aiding in axon guidance. FGF-9 binds to the PTCH1 receptor and activates target gene transcription when in association with SMO, while PTCH1 represses SMO signaling in the absence of FGF-9. CDK1-CCNE1 Heterodimer Protein, Human (sf9, His-GST) is a recombinant protein dimer complex containing human-derived CDK1-CCNE1 Heterodimer protein, expressed by Sf9 insect cells, with N-10*His, N-GST labeled tag. CDK1-CCNE1 Heterodimer Protein, Human (sf9, His-GST), has molecular weight of ~109.7 (60.4+49.3) kDa.

HY-P75668

	CDK1 Protein, Human (sf9, GST) Cyclin-dependent kinase 1; Cdk1; p34 protein kinase; CDC2; CDC28A; CdkN1; P34CDC2	Human	Sf9 insect cells
	The CDK1/CDC2-cyclin-B complex is a key regulator in the cell cycle. It plays an important role in cell division and development and regulates a variety of cellular activities, including chromosome segregation, nuclear membrane rupture, cytokinesis, etc. The activity of CDK1 is regulated by a variety of phosphorylation and dephosphorylation, thereby controlling the progression of the cell cycle and the DNA repair process. CDK1 Protein, Human (sf9, GST) is the recombinant human-derived CDK1 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of CDK1 Protein, Human (sf9, GST) is 297 a.a., with molecular weight of ~53 kDa.

HY-P75669

	CDK1 Protein, Mouse (sf9, His-GST) Cyclin-dependent kinase 1; Cdk1; p34 protein kinase; CDC2; CDC28A; CdkN1; P34CDC2	Mouse	Sf9 insect cells
	The CDK1 protein centrally controls the eukaryotic cell cycle, coordinating the G2-M transition and mitotic events. It interacts with a variety of cell cycle proteins, phosphorylates a variety of substrates, and affects cell cycle regulation, DNA repair, and apoptosis. CDK1 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CDK1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of CDK1 Protein, Mouse (sf9, His-GST) is 297 a.a., with molecular weight of ~57 kDa.

HY-P701364

	CDK3-CCNE1 Heterodimer Protein, Human (Sf9) Cdk3; CCNE1; Cyclin-dependent kinase 3; Cell division protein kinase 3; G1/S-specific cyclin-E1	Human	Sf9 insect cells
	CDK3 protein is a serine/threonine protein kinase that plays a key role in regulating the eukaryotic cell cycle, especially affecting the G0-G1 and G1-S transitions. It interacts with CCNC/cyclin-C during interphase and phosphorylates substrates such as histone H1, ATF1, RB1, and CABLES1. CDK3-CCNE1 Heterodimer Protein, Human (Sf9) is a recombinant protein dimer complex containing human-derived CDK3-CCNE1 Heterodimer protein, expressed by Sf9 insect cells , with tag free.

HY-P702680

CDK3-CCNC Protein, Human (sf9, GST, Flag, His)

Cdk3; CCNE1; Cyclin-dependent kinase 3; Cell division protein kinase 3; G1/S-specific cyclin-E1
Human Sf9 insect cells
HY-P702681

CDK3-CCNE2 Protein, Human (sf9, GST, Flag, His)

Cdk3; CCNE1; Cyclin-dependent kinase 3; Cell division protein kinase 3; G1/S-specific cyclin-E1
Human Sf9 insect cells
HY-P702684

CDK4-CCND3 Protein, Human (sf9, GST, His)

Cdk4; cyclin-dependent kinase 4; PSK J3; cell division protein kinase 4; CMM3; PSK-J3; MGC14458
Human Sf9 insect cells

HY-P701371

	CDK7-CCNH-MNAT1 Protein, Human (Sf9) Cdk7; CCNH; MNAT1; Cyclin-dependent kinase 7; 39 kDa protein kinase; p39 Mo15; Cdk-activating kinase 1; Cell division protein kinase 7; Serine/threonine-protein kinase 1; TFIIH basal transcription factor complex kinase subunit; Cyclin-H; MO15-associated protein; p34; p37; Cdk-activating kinase assembly factor MAT1; Cdk7/cyclin-H assembly factor; Cyclin-G1-interacting protein; Menage a trois; RING finger protein 66; RING finger protein MAT1; p35; p36	Human	Sf9 insect cells
	Together with its regulatory partners CCNH and MNAT1, CDK7 functions as an important serine/threonine kinase in cell cycle regulation and RNA polymerase II-mediated transcription. As the catalytic subunit of the CDK-activated kinase (CAK) complex, CDK7 plays a key role in activating CDK1/cyclin-B and CDK2/cyclin during cell cycle transitions. CDK7-CCNH-MNAT1 Protein, Human (Sf9) is the recombinant human-derived CDK7-CCNH-MNAT1 protein, expressed by Sf9 insect cells , with tag free.

HY-P701365

	CDK3-CCNE1 Heterodimer Protein, Human (Sf9, GST, FLAG, His) Cdk3; CCNE1; Cyclin-dependent kinase 3; Cell division protein kinase 3; G1/S-specific cyclin-E1	Human	Sf9 insect cells
	CDK3 protein is a serine/threonine protein kinase that plays a key role in regulating the eukaryotic cell cycle, especially affecting the G0-G1 and G1-S transitions. It interacts with CCNC/cyclin-C during interphase and phosphorylates substrates such as histone H1, ATF1, RB1, and CABLES1. CDK3-CCNE1 Heterodimer Protein, Human (Sf9, GST, FLAG, His) is a recombinant protein dimer complex containing human-derived CDK3-CCNE1 Heterodimer protein, expressed by Sf9 insect cells , with N-6*His, N-Flag, N-GST labeled tag.

HY-P702682

CDK4-CCND1 Protein, Human (sf9, GST, Flag, His)

Cdk4; cyclin-dependent kinase 4; PSK J3; cell division protein kinase 4; CMM3; PSK-J3; MGC14458
Human Sf9 insect cells
HY-P702683

CDK4-CCND2 Protein, Human (sf9, GST, Flag, His)

Cdk4; cyclin-dependent kinase 4; PSK J3; cell division protein kinase 4; CMM3; PSK-J3; MGC14458
Human Sf9 insect cells

HY-P701367

	CDK6-CCND2 Heterodimer Protein, Human (Sf9) Cdk6; CCND2; Cyclin-dependent kinase 6; Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE; G1/S-specific cyclin-D2	Human	Sf9 insect cells
	The CDK6ic complex is an important serine/threonine protein kinase that regulates cell cycle progression and differentiation, promoting the G1/S transition by phosphorylating substrates such as pRB/RB1 and NPM1. It interacts with D-type G1 cyclins during interphase to form active pRB/RB1 kinase, which controls cell cycle entry. CDK6-CCND2 Heterodimer Protein, Human (Sf9) is a recombinant protein dimer complex containing human-derived CDK6-CCND2 Heterodimer protein, expressed by Sf9 insect cells , with tag free.

HY-P701369

	CDK6-CCND3 Heterodimer Protein, Human (Sf9) Cdk6; CCND3; Cyclin-dependent kinase 6; Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE; G1/S-specific cyclin-D3	Human	Sf9 insect cells
	The CDK6ic complex is an important serine/threonine protein kinase that regulates cell cycle progression and differentiation, promoting the G1/S transition by phosphorylating substrates such as pRB/RB1 and NPM1. It interacts with D-type G1 cyclins during interphase to form active pRB/RB1 kinase, which controls cell cycle entry. CDK6-CCND3 Heterodimer Protein, Human (Sf9) is a recombinant protein dimer complex containing human-derived CDK6-CCND3 Heterodimer protein, expressed by Sf9 insect cells , with tag free.

HY-P702688

	CDK7-CCNH-MNAT1 Protein, Human (sf9, GST, His, Flag) Cdk7; cyclin-dependent kinase 7; cyclin dependent kinase 7 (homolog of Xenopus MO15 Cdk activating kinase) , cyclin dependent kinase 7 (MO15 homolog, Xenopus laevis, Cdk activating kinase); CAK; CAK1; CdkN7; MO15; STK1; p39 Mo15; protein kinase; 39 KDa protein kinase; kinase subunit of CAK; Cdk-activating kinase 1; serine/threonine kinase stk1; cell division protein kinase 7; serine/threonine protein kinase 1; serine/threonine-protein kinase 1; serine/threonine protein kinase MO15	Human	Sf9 insect cells

HY-P701368

	CDK6-CCND2 Heterodimer Protein, Human (Sf9, GST, FLAG, His) Cdk6; CCND2; Cyclin-dependent kinase 6; Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE; G1/S-specific cyclin-D2	Human	Sf9 insect cells
	The CDK6ic complex is an important serine/threonine protein kinase that regulates cell cycle progression and differentiation, promoting the G1/S transition by phosphorylating substrates such as pRB/RB1 and NPM1. It interacts with D-type G1 cyclins during interphase to form active pRB/RB1 kinase, which controls cell cycle entry. CDK6-CCND2 Heterodimer Protein, Human (Sf9, GST, FLAG, His) is a recombinant protein dimer complex containing human-derived CDK6-CCND2 Heterodimer protein, expressed by Sf9 insect cells , with N-Flag, N-8*His, N-GST labeled tag.

HY-P701370

	CDK6-CCND3 Heterodimer Protein, Human (Sf9, GST, His) Cdk6; CCND3; Cyclin-dependent kinase 6; Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE; G1/S-specific cyclin-D3	Human	Sf9 insect cells
	The CDK6ic complex is an important serine/threonine protein kinase that regulates cell cycle progression and differentiation, promoting the G1/S transition by phosphorylating substrates such as pRB/RB1 and NPM1. It interacts with D-type G1 cyclins during interphase to form active pRB/RB1 kinase, which controls cell cycle entry. CDK6-CCND3 Heterodimer Protein, Human (Sf9, GST, His) is a recombinant protein dimer complex containing human-derived CDK6-CCND3 Heterodimer protein, expressed by Sf9 insect cells , with N-10*His, N-GST labeled tag.

HY-P702687

	CDK6-CCND1 Protein, Human (sf9, GST, Flag, His) Cdk6; CCND2; Cyclin-dependent kinase 6; Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE; G1/S-specific cyclin-D2	Human	Sf9 insect cells

HY-P702699

	CDK19-CCNC-MED12 Protein, Human (sf9, GST, Flag, His) CDC2L6; Cdk19; cyclin dependent kinase 19; Cdk11; CDC2L6; bA346C16.3; cyclin-dependent kinase 19; CDC2-related protein kinase 6; Cdk8-like cyclin-dependent kinase; cell division cycle 2-like 6 (Cdk8-like); cell division cycle 2-like protein kinase 6; cell division protein kinase 19; cyclin dependent kinase 19 variant 2; cyclin-dependent kinase (CDC2-like) 11; cyclin-dependent kinase 11; death-preventing kinase; EC 2.7.11.22	Human	Sf9 insect cells

HY-P72785

	CDKN2A Protein, Human Cyclin-dependent kinase inhibitor 2A; Cdk4I; MTS-1; p16INK4A	Human	E. coli
	CDKN2A Protein, a potent negative regulator of cell proliferation, forms strong interactions with CDK4 and CDK6, hindering their association with cyclins D and retinoblastoma protein phosphorylation. Acting in a heterodimeric manner, predominantly with CDK6, CDKN2A inhibits cyclin D-CDK4 kinase activity and interacts with ISCO2, contributing to its cell cycle regulatory role. CDKN2A Protein, Human is the recombinant human-derived CDKN2A protein, expressed by E. coli , with tag free. The total length of CDKN2A Protein, Human is 155 a.a., with molecular weight of ~19.12 kDa.

HY-P700570

	CDKN1A Protein, Human (GST) Cdk-interacting protein 1Melanoma differentiation-associated protein 6 ; MDA-6p21	Human	E. coli
	The CDKN1A protein critically controls cell cycle progression and mediates DNA damage-induced G2 arrest through p53/TP53-dependent and CREB3L1-mediated p53-independent pathways. It inhibits cyclin-dependent kinase activity, blocking cell cycle progression by preventing phosphorylation of key substrates. CDKN1A Protein, Human (GST) is the recombinant human-derived CDKN1A protein, expressed by E. coli , with N-GST labeled tag. The total length of CDKN1A Protein, Human (GST) is 163 a.a., with molecular weight of 45 kDa.

HY-P701372

	CDK8-CCNC-MED12 Protein, Human (Sf9) Cdk8; CCNC; MED12; Cyclin-dependent kinase 8; Cell division protein kinase 8; Mediator complex subunit Cdk8; Mediator of RNA polymerase II transcription subunit Cdk8; Protein kinase K35; Cyclin-C; SRB11 homolog; hSRB11; Mediator of RNA polymerase II transcription subunit 12; Activator-recruited cofactor 240 kDa component; ARC240; CAG repeat protein 45; Mediator complex subunit 12; OPA-containing protein; Thyroid hormone receptor-associated protein complex 230 kDa component; Trap230; Trinucleotide repeat-containing gene 11 protein	Human	Sf9 insect cells
	The CDK8-CCNC-MED12 protein is an important component of the mediator complex, acting as a bridge for gene transcription regulation, transmitting information from gene-specific regulatory factors to RNA polymerase II. It is recruited to the promoter, assembles a preinitiation complex, and promotes transcription. CDK8-CCNC-MED12 Protein, Human (Sf9) is the recombinant human-derived CDK8-CCNC-MED12 protein, expressed by Sf9 insect cells , with tag free.

HY-P701373

	CDK8-CCNC-MED12 Protein, Human (Sf9, GST, FLAG, His) Cdk8; CCNC; MED12; Cyclin-dependent kinase 8; Cell division protein kinase 8; Mediator complex subunit Cdk8; Mediator of RNA polymerase II transcription subunit Cdk8; Protein kinase K35; Cyclin-C; SRB11 homolog; hSRB11; Mediator of RNA polymerase II transcription subunit 12; Activator-recruited cofactor 240 kDa component; ARC240; CAG repeat protein 45; Mediator complex subunit 12; OPA-containing protein; Thyroid hormone receptor-associated protein complex 230 kDa component; Trap230; Trinucleotide repeat-containing gene 11 protein	Human	Sf9 insect cells
	The CDK8-CCNC-MED12 protein is an important component of the mediator complex, acting as a bridge for gene transcription regulation, transmitting information from gene-specific regulatory factors to RNA polymerase II. It is recruited to the promoter, assembles a preinitiation complex, and promotes transcription. CDK8-CCNC-MED12 Protein, Human (Sf9, GST, FLAG, His) is the recombinant human-derived CDK8-CCNC-MED12 protein, expressed by Sf9 insect cells , with N-6*His, N-Flag, N-GST labeled tag.

HY-P701374

	CDK9-CCNK Heterodimer Protein, Human (Sf9) Cdk9; CCNK; Cyclin-dependent kinase 9; C-2K; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit; Cyclin-K	Human	Sf9 insect cells
	The CDK9 protein plays a central role in transcriptional regulation, promoting the transition from ineffective to efficient elongation by phosphorylating POLR2A, SUPT5H, and RDBP. As part of the CDK9/cyclin-T complex, it participates in phosphorylation events affecting EP300, MYOD1, RPB1/POLR2A, AR, DSIF, and NELFE. CDK9-CCNK Heterodimer Protein, Human (Sf9) is a recombinant protein dimer complex containing human-derived CDK9-CCNK Heterodimer protein, expressed by Sf9 insect cells , with tag free.

HY-P71531

	SKP2 Protein, Human (His-SUMO) Cdk2/Cyclin A associated protein p45; Cyclin A/Cdk2 associated protein p45; Cyclin-A/Cdk2-associated protein p45; F box protein Skp2; F box/LRR repeat protein 1; F-box protein Skp2; F-box/LRR-repeat protein 1; FBL 1; FBL1; FBXL 1; FBXL1; FLB 1; FLB1; MGC1366; p45; p45skp2	Human	E. coli
	SKP2 serves as a substrate recognition component in the SCF E3 ubiquitin-protein ligase complex, directing ubiquitination and proteasomal degradation of key proteins in the cell cycle, signaling, and transcription. It crucially recognizes phosphorylated CDKN1B/p27kip and regulates the G1/S transition. SKP2 Protein, Human (His-SUMO) is the recombinant human-derived SKP2 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of SKP2 Protein, Human (His-SUMO) is 424 a.a., with molecular weight of ~63.8 kDa.

HY-P701366

	CDK6-CCND1 Heterodimer Protein, Human (Sf9) Cdk6; CCND1; Cyclin-dependent kinase 6; Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE; G1/S-specific cyclin-D1; B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogene	Human	Sf9 insect cells
	The CDK6ic complex is an important serine/threonine protein kinase that regulates cell cycle progression and differentiation, promoting the G1/S transition by phosphorylating substrates such as pRB/RB1 and NPM1. It interacts with D-type G1 cyclins during interphase to form active pRB/RB1 kinase, which controls cell cycle entry. CDK6-CCND1 Heterodimer Protein, Human (Sf9) is a recombinant protein dimer complex containing human-derived CDK6-CCND1 Heterodimer protein, expressed by Sf9 insect cells , with tag free.

HY-P701375

	CDK9-CCNK Heterodimer Protein, Human (Sf9, GST, FLAG) Cdk9; CCNK; Cyclin-dependent kinase 9; C-2K; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit; Cyclin-K	Human	Sf9 insect cells
	The CDK9 protein plays a central role in transcriptional regulation, promoting the transition from ineffective to efficient elongation by phosphorylating POLR2A, SUPT5H, and RDBP. As part of the CDK9/cyclin-T complex, it participates in phosphorylation events affecting EP300, MYOD1, RPB1/POLR2A, AR, DSIF, and NELFE. CDK9-CCNK Heterodimer Protein, Human (Sf9, GST, FLAG) is a recombinant protein dimer complex containing human-derived CDK9-CCNK Heterodimer protein, expressed by Sf9 insect cells , with N-Flag, N-GST labeled tag.

HY-P702689

	CDK9-CCNT1 Protein, Human (sf9, GST, His) Cdk9; CCNK; Cyclin-dependent kinase 9; C-2K; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit; Cyclin-K	Human	Sf9 insect cells

HY-P702690

	CDK9-CCNT2 Protein, Human (sf9, GST, Flag, His) Cdk9; CCNK; Cyclin-dependent kinase 9; C-2K; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit; Cyclin-K	Human	Sf9 insect cells

HY-P701360

	CDK12-CCNK Heterodimer Protein, Human (Sf9) Cdk12; CCNK; Cyclin-dependent kinase 12; Cdc2-related kinase; arginine/serine-rich; CrkRS; Cell division cycle 2-related protein kinase 7; CDC2-related protein kinase 7; Cell division protein kinase 12; hCdk12; Cyclin-K	Human	Sf9 insect cells
	The CDK12 protein is a cyclin-dependent kinase that critically phosphorylates the C-terminal domain of POLR2A, thereby regulating transcription elongation. It selectively targets "Ser-5" phosphorylated at "Ser-7" in the CTD repeat and can also target "Ser-2". CDK12-CCNK Heterodimer Protein, Human (Sf9) is a recombinant protein dimer complex containing human-derived CDK12-CCNK Heterodimer protein, expressed by Sf9 insect cells , with tag free.

HY-P701377

	CDK9-CCNT2 Heterodimer Protein, Human (Sf9) Cdk9; CCNT2; Cyclin-dependent kinase 9; C-2K; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit; Cyclin-T2; CycT2	Human	Sf9 insect cells
	The CDK9 protein plays a central role in transcriptional regulation, promoting the transition from ineffective to efficient elongation by phosphorylating POLR2A, SUPT5H, and RDBP. As part of the CDK9/cyclin-T complex, it participates in phosphorylation events affecting EP300, MYOD1, RPB1/POLR2A, AR, DSIF, and NELFE. CDK9-CCNT2 Heterodimer Protein, Human (Sf9) is a recombinant protein dimer complex containing human-derived CDK9-CCNT2 Heterodimer protein, expressed by Sf9 insect cells , with tag free.

HY-P701361

	CDK12-CCNK Heterodimer Protein, Human (Sf9, GST, FLAG) Cdk12; CCNK; Cyclin-dependent kinase 12; Cdc2-related kinase; arginine/serine-rich; CrkRS; Cell division cycle 2-related protein kinase 7; CDC2-related protein kinase 7; Cell division protein kinase 12; hCdk12; Cyclin-K	Human	Sf9 insect cells
	The CDK12 protein is a cyclin-dependent kinase that critically phosphorylates the C-terminal domain of POLR2A, thereby regulating transcription elongation. It selectively targets "Ser-5" phosphorylated at "Ser-7" in the CTD repeat and can also target "Ser-2". CDK12-CCNK Heterodimer Protein, Human (Sf9, GST, FLAG) is a recombinant protein dimer complex containing human-derived CDK12-CCNK Heterodimer protein, expressed by Sf9 insect cells , with N-Flag, N-GST labeled tag.

HY-P701376

	CDK9-CCNT1 Heterodimer Protein, Human (Sf9) Cdk9; CCNT1; Cyclin-dependent kinase 9; C-2K; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit; Cyclin-T1; CycT1; Cyclin-T	Human	Sf9 insect cells
	The CDK9 protein plays a central role in transcriptional regulation, promoting the transition from ineffective to efficient elongation by phosphorylating POLR2A, SUPT5H, and RDBP. As part of the CDK9/cyclin-T complex, it participates in phosphorylation events affecting EP300, MYOD1, RPB1/POLR2A, AR, DSIF, and NELFE. CDK9-CCNT1 Heterodimer Protein, Human (Sf9) is a recombinant protein dimer complex containing human-derived CDK9-CCNT1 Heterodimer protein, expressed by Sf9 insect cells , with tag free.

HY-P702692

	CDK12-CCNT1 Protein, Human (sf9, GST, Flag, His) Cdk12; CCNK; Cyclin-dependent kinase 12; Cdc2-related kinase; arginine/serine-rich; CrkRS; Cell division cycle 2-related protein kinase 7; CDC2-related protein kinase 7; Cell division protein kinase 12; hCdk12; Cyclin-K	Human	Sf9 insect cells

HY-P702696

	CDK16-CCNY Protein, Human (sf9, GST, Flag) Cdk16; cyclin-dependent kinase 16; PCTAIRE protein kinase 1 , PCTK1; FLJ16665; PCTAIRE; PCTAIRE1; PCTGAIRE; serine/threonine protein kinase; PCTAIRE-motif protein kinase 1; cell division protein kinase 16; serine/threonine-protein kinase PCTAIRE-1; PCTK1	Human	Sf9 insect cells

HY-P702697

	CDK17-CCNY Protein, Human (sf9, GST, Flag) Cdk17; cyclin-dependent kinase 17; PCTAIRE protein kinase 2 , PCTK2; PCTAIRE2; PCTAIRE-motif protein kinase 2; cell division protein kinase 17; protein kinase cdc2-related PCTAIRE-2; serine/threonine-protein kinase PCTAIRE-2; PCTK2	Human	Sf9 insect cells

HY-P702698

	CDK18-CCNY Protein, Human (sf9, GST, Flag) Cdk18; cyclin-dependent kinase 18; PCTAIRE protein kinase 3 , PCTK3; PCTAIRE3; PCTAIRE protein kinase 3; PCTAIRE-motif protein kinase 3; cell division protein kinase 18; serine/threonine-protein kinase PCTAIRE-3; PCTK3; PCTAIRE	Human	Sf9 insect cells

HY-P76536

	PCTAIRE1 Protein, Human (sf9, GST) Cyclin-dependent kinase 16; PCTAIRE-motif protein kinase 1; Cdk16; PCTAIRE1; PCTK1	Human	Sf9 insect cells
	PCTAIRE1 protein is a multifunctional kinase that plays a key role in vesicle-mediated transport and regulation of GH1 release, emphasizing neuroendocrine function. Its involvement includes NSF phosphorylation, influencing vesicle dynamics, and important contributions to spermatogenesis and reproductive processes. PCTAIRE1 Protein, Human (sf9, GST) is the recombinant human-derived PCTAIRE1 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of PCTAIRE1 Protein, Human (sf9, GST) is 496 a.a., with molecular weight of ~73 kDa.

HY-P702601

CDK6 Protein, Human (Sf9, His)

Cyclin-dependent kinase 6; Cell division protein kinase 6; CdkN6; EC:2.7.11.22
Human Sf9 insect cells

Cat. No.	Product Name	Chemical Structure

HY-16297AS

Abemaciclib-d8
Abemaciclib-d₈ is the deuterium labeled Abemaciclib. Abemaciclib (LY2835219) is a selective CDK4/6 inhibitor with IC50 values of 2 nM and 10 nM for CDK4 and CDK6, respectively.

HY-15777AS

Ribociclib-d6 hydrochloride
Ribociclib-d₆ (hydrochloride) is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1].

HY-15777S1

Ribociclib-d8
Ribociclib-d₈ is the deuterium labeled Ribociclib[1]. Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[2].

HY-151580S

CDK2-IN-14-d3

CDK2-IN-14-d₃ is a potent and selective CDK2 inhibitor. CDK2-IN-14-d₃ can be used in research of cancer[1].

HY-15777S

Ribociclib-d6
Ribociclib-d₆ is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1].

HY-126534S

Abemaciclib metabolite M18-d8
Abemaciclib metabolite M18-d₈ is the deuterium labeled Abemaciclib metabolite M18. Abemaciclib metabolite M18 (LSN3106729), the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 and a CRBN ligand have been used to design PROTAC CDK4/6 degrader[1][2].

HY-129336S

Abemaciclib metabolite M20-d8
Abemaciclib metabolite M20-d₈ is the deuterium labeled Abemaciclib metabolite M20. Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor[1].

HY-50767S

Palbociclib-d8
Palbociclib-d₈ is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM, respectively. Palbociclib has the potential for ER-positive and HER2-negative breast cancer research[1].

HY-50767S1

Palbociclib-d4 hydrochloride
Palbociclib-d₄ (hydrochloride) is the deuterium labeled Palbociclib hydrochloride. Palbociclib (PD 0332991) is a selective CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM, respectively. Palbociclib has the potential for ER-positive and HER2-negative breast cancer research[1].

HY-128669S

Abemaciclib metabolite M2-d6
Abemaciclib metabolite M2-d₆ is the deuterium labeled Abemaciclib metabolite M2. Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity[1][2].

HY-N1127S

Tricin-d6
Tricin-d₆ is the deuterium labeled Tricin[1]. Tricin is a natural flavonoid present in large amounts in Triticum aestivum. Tricin can inhibit human cytomegalovirus (HCMV) replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells via the upregulation of focal-adhesion-finase (FAK)-targeting microRNA-7[2][3][4].

Cat. No.	Product Name	Application	Reactivity

HY-P80076

Cdk2 Antibody	WB, ICC/IF, IHC-P, IP	Human, Mouse, Rat
Cdk2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 34 kDa, targeting to Cdk2. It can be used for WB,ICC/IF,IHC-P,IP assays with tag free, in the background of Human, Mouse.

HY-P80077

Cdk4 Antibody	WB, ICC/IF, IHC-P, IP	Human, Mouse
Cdk4 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 34 kDa, targeting to Cdk4. It can be used for WB,ICC/IF,IHC-P,IP assays with tag free, in the background of Human, Mouse.

HY-P80078

Cdk5 Antibody	WB, IHC-P, FC, IP	Human, Mouse, Rat
Cdk5 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 33 kDa, targeting to Cdk5. It can be used for WB,IHC-P,FC,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80079

Cdk6 Antibody	WB, ICC/IF, IHC-P, FC	Human
Cdk6 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 37 kDa, targeting to Cdk6. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human.

HY-P82827

Phospho-CDK1/2 (Thr14) Antibody (YA2572)

CdkN2; p33(Cdk2)
WB, IHC-P, IP Human

HY-P80613

CDK5 Antibody (YA796) Cdk 5; Cdk5; Cdk5_HUMAN; Cell division protein kinase 5; Crk6; Cyclin dependent kinase 5; Cyclin-dependent kinase 5; Protein kinase Cdk5 splicing; PSSALRE; Serine threonine protein kinase PSSALRE; Serine/threonine-protein kinase PSSALRE; Tau protein kinas	WB, ICC/IF	Human, Mouse, Rat, Monkey
CDK5 Antibody (YA796) is a non-conjugated and Mouse origined monoclonal antibody about 33 kDa, targeting to CDK5 (2E8). It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse, Rat, Monkey.

HY-P80612

CDK16 Antibody PCTK1; PCTAIRE; PCTAIRE1; PCTGAIRE	WB	Human
CDK16 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 56 kDa, targeting to CDK16. It can be used for WB assays with tag free, in the background of Human.

HY-P81578

CDK8 Antibody (YA1323)

Cyclin-dependent kinase 8
IHC-P Human, Mouse

HY-P80611

CDK1 Antibody Cdk1; CDC2; CDC28A; CdkN1; P34CDC2; Cyclin-dependent kinase 1; Cdk1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase	WB, IP	Human
CDK1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 34 kDa, targeting to CDK1. It can be used for WB,IP assays with tag free, in the background of Human.

HY-P80798

*Phospho-CDK2 (Tyr15) Antibody* Cdk2; CdkN2; Cyclin-dependent kinase 2; Cell division protein kinase 2; p33 protein kinase	WB, IP	Human, Hamster, Rat
Phospho-CDK2 (Tyr15) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 34 kDa, targeting to Phospho-CDK2 (Tyr15). It can be used for WB,IP assays with tag free, in the background of Human, Hamster, Rat.

HY-P80796

*Phospho-CDK1 (Tyr15) Antibody* Cdk1; CDC2; CDC28A; CdkN1; P34CDC2; Cyclin-dependent kinase 1; Cdk1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase	WB	Human, Mouse, Rat
Phospho-CDK1 (Tyr15) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 34 kDa, targeting to Phospho-CDK1 (Tyr15). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P80389

Cdk7 Antibody Cdk7_HUMAN; Cyclin-dependent kinase 7; EC:2.7.11.22; EC:2.7.11.23; Cdk7; CAK; CAK1; CdkN7; MO15; STK1; 39 kDa protein kinase (p39 Mo15); Cdk-activating kinase 1; Cell division protein kinase 7; Serine/threonine-protein kinase 1; TFIIH basal transcription factor complex kinase subunit	WB；ELISA；IHC-P；IHC-F；ICC；IF	Human, Mouse, Rat
Cdk7 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 39 kDa, targeting to Cdk7. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human.

HY-P80614

CDK9 Antibody TAK; C-2k; CTK1; CDC2L4; PITALRE	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
CDK9 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 43 kDa, targeting to CDK9. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P82183

CDK5RAP3 Antibody (YA1928)

C53; IC53; LZAP; HSF-27; MST016; PP1553; OK/SW-cl.114
WB, IHC-P, IP Human, Mouse

HY-P80774

p21 Antibody CdkN1A; CAP20; CdkN1; CIP1; MDA6; PIC1; SDI1; WAF1; Cyclin-dependent kinase inhibitor 1; Cdk-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21	WB, ICC/IF	Human, Mouse, Rat
p21 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 18 kDa, targeting to p21. It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P80773

p21 Antibody (YA254) CdkN1A; CAP20; CdkN1; CIP1; MDA6; PIC1; SDI1; WAF1; Cyclin-dependent kinase inhibitor 1; Cdk-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21	WB	Human, Mouse
p21 Antibody (YA254) is a non-conjugated and Rabbit origined monoclonal antibody about 18 kDa, targeting to p21. It can be used for WB assays with tag free, in the background of Human, Mouse.

HY-P80615

CDKN2A Antibody CdkN2A; CdkN2; MTS1; Cyclin-dependent kinase inhibitor 2A; isoforms 1/2/3; Cyclin-dependent kinase 4 inhibitor A; Cdk4I; Multiple tumor suppressor 1; MTS-1; p16-INK4a; p16-INK4; p16INK4A	WB, IP	Human, Mouse
CDKN2A Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 17 kDa, targeting to CDKN2A. It can be used for WB,IP assays with tag free, in the background of Human, Mouse.

HY-P80797

*Phospho-CDK1/2/3 (Thr14) Antibody* CDC2; CDC28A; P34CDC2	WB, IP	Human, Hamster
Phospho-CDK1/2/3 (Thr14) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 34 kDa, targeting to Phospho-CDK1/2/3 (Thr14). It can be used for WB,IP assays with tag free, in the background of Human, Hamster.

HY-P81587

SKP2 Antibody (YA1332) SKP2; FBXL1; S-phase kinase-associated protein 2; Cyclin-A/Cdk2-associated protein p45; F-box protein Skp2; F-box/LRR-repeat protein 1; p45skp2	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

HY-P82229

SKP1 Antibody (YA1974) SKP1; EMC19; OCP2; SKP1A; TCEB1L; S-phase kinase-associated protein 1; Cyclin-A/Cdk2-associated protein p19; Organ of Corti protein 2; OCP-2; Organ of Corti protein II; OCP-II; RNA polymerase II elongation factor-like protein; SIII; Transcr	WB, ICC/IF	Human, Mouse, Rat

Cat. No.	Product Name		Classification

HY-130296

Palbociclib-propargyl PROTAC Cdk6 ligand 1		Alkynes
Palbociclib-propargyl is a ligand for target protein *CDK6* for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC₅₀ of 2.1 nM for CDK6 . Palbociclib-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-125843

Pomalidomide-PEG1-C2-N3 Cereblon Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 50		Azide
Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC₅₀ of 2.1 nM . Pomalidomide-PEG1-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-116423

JH295		Alkynes
JH295 is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC₅₀ of 770 nM. JH295 inhibits cellular Nek2 via alkylation of Cys22. JH295 is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint . JH295 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-148213

CDK2/4/6-IN-1		Alkynes
CDK2/4/6-IN-1(example 29) is a *CDK2/4/6* inhibitor with IC₅₀ values of 2.5, 23.7 and 44.3 nM for CDK2, CDK4 and CDK6, respectively. CDK2/4/6-IN-1 can be used in cancer research . CDK2/4/6-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-116423A

JH295 hydrate		Alkynes
JH295 hydrate is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC₅₀ of 770 nM. JH295 hydrate inhibits cellular Nek2 via alkylation of Cys22. JH295 hydrate is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint . JH295 (hydrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks