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Results for "

Chalcone

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (1) Akt (1) Apoptosis (11) Autophagy (2) Bacterial (8) Bcl-2 Family (2) Carbonic Anhydrase (1) Caspase (2) Cholinesterase (ChE) (1) Cytochrome P450 (1) Dengue virus (1) EGFR (1) Ferroptosis (1) Fungal (2) HDAC (1) Influenza Virus (2) Interleukin Related (2) Keap1-Nrf2 (1) Lactate Dehydrogenase (1) MicroRNA (1) Microtubule/Tubulin (3) Mitochondrial Metabolism (1) NF-κB (5) NOD-like Receptor (NLR) (3) Oxidative Phosphorylation (1) Parasite (4) Phosphodiesterase (PDE) (1) Proteasome (2) Reactive Oxygen Species (3) STAT (1) TMV (3) TNF Receptor (1) Toll-like Receptor (TLR) (1) TRP Channel (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (28) Cardiovascular Disease (3) Infection (12) Inflammation/Immunology (22) Metabolic Disease (3) Neurological Disease (4)

By Targets:

Adenosine Receptor (1)

Akt (1)

Apoptosis (11)

Autophagy (2)

Bacterial (8)

Bcl-2 Family (2)

Carbonic Anhydrase (1)

Caspase (2)

Cholinesterase (ChE) (1)

Cytochrome P450 (1)

Dengue virus (1)

EGFR (1)

Ferroptosis (1)

Fungal (2)

HDAC (1)

Influenza Virus (2)

Interleukin Related (2)

Keap1-Nrf2 (1)

Lactate Dehydrogenase (1)

MicroRNA (1)

Microtubule/Tubulin (3)

Mitochondrial Metabolism (1)

NF-κB (5)

NOD-like Receptor (NLR) (3)

Oxidative Phosphorylation (1)

Parasite (4)

Phosphodiesterase (PDE) (1)

Proteasome (2)

Reactive Oxygen Species (3)

STAT (1)

TMV (3)

TNF Receptor (1)

Toll-like Receptor (TLR) (1)

TRP Channel (1)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (28)

Cardiovascular Disease (3)

Infection (12)

Inflammation/Immunology (22)

Metabolic Disease (3)

Neurological Disease (4)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-121054

*Chalcone*	Bacterial Parasite	Inflammation/Immunology Cancer
Chalcone is isolated from Glycyrrhiza uralensis and used to synthesize chalcone derivatives. Chalcone derivatives possess varied biological and pharmacological activity, including anti-inflammatory, antioxidative, antibacterial, anticancer, and anti-parasitic activities .

HY-W023983

Chalcone dibromide	Others	Cancer
Chalcone dibromide is a useful synthon in the synthesis of a large number of bioactive molecules such as pyrazolines, hydroxy pyrazolines, isoxazoles etc. Chalcone dibromide possesses antioxidant effects against tumor cells by inhibiting superoxide production and lipid peroxidation. Chalcone dibromide can be used for cancer disease research .

HY-N3007

Naringenin chalcone 1 Publications Verification	Others	Inflammation/Immunology
Naringenin chalcone is an intermediate in flavonol biosynthesis and is spontaneously metabolized into naringenin (NAR) by chalcone isomerase. Naringenin chalcone has anti-inflammatory and antiallergic activities .

HY-115550

Chalcone 4 hydrate

Parasite Infection

Chalcone 4 hydrate is an anti-parasite agent, inhibits the growth of Babesia and Theileria .

Chalcone 4 hydrate	Parasite	Infection
Chalcone 4 hydrate is an anti-parasite agent, inhibits the growth of Babesia and Theileria .

HY-145858

Chalcones A-N-5	Ferroptosis	Cancer
Chalcones A-N-5 is a trihydroxy chalcone derivative compound. Chalcones A-N-5 doesn’t show cytotoxicity at the concentration lower than 100 µM (with IC₅₀ > 1 mM), but has a significant effect on promoting cell proliferation. Chalcones A-N-5 potentially promotes neuronal cell growth in the damaged brain tissue. Chalcones A-N-5 also inhibits ferroptosis induced by RSL or erastin and reduces the lipid peroxidation levels induced by Aβ1-42 protein aggregation. Chalcones A-N-5 is a promising molecular skeleton candidate for further development of lead compound for in vivo test to research AD .

HY-Y0598

trans-Chalcone
trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activity .

HY-N3007A

(E)-Naringenin chalcone	Others	Inflammation/Immunology
(E)-Naringenin chalcone is an orally active anti-allergic agent. (E)-Naringenin chalcone also has antioxidant, anti-inflammatory activities. (E)-Naringenin chalcone can improve adipocyte functions. (E)-Naringenin chalcone inhibits histamine release from rat peritoneal mast cell .

HY-N9551

Eriodictyol chalcone

Cytochrome P450 Metabolic Disease

Eriodictyol chalcone possesses both anti-aromatase and an anti-17β-HSD activity .

Eriodictyol chalcone	Cytochrome P450	Metabolic Disease
Eriodictyol chalcone possesses both anti-aromatase and an anti-17β-HSD activity .

HY-N7515

Pinocembrin chalcone 2',4',6'-TrihydroxyChalcone	Bacterial	Inflammation/Immunology
Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) is an antibacterial compound from Helichrysum Trilineatum. Pinocembrin chalcone can prevent gastric ulcers in rats .

HY-N3057

Pinostrobin chalcone	Others	Cancer
Pinostrobin chalcone is found to be potent natural cytotoxic compounds against MDA-MB-231 and HT-29 colon cancer cell lines(IC₅₀ = 20.42±2.23 and 22.51±0.42 μg/mL) .

HY-N8690

4,2'-Dihydroxy-4'-methoxychalcone

Others Inflammation/Immunology

4,2'-Dihydroxy-4'-methoxychalcone, a chalcone, shows allergy-preventive effects .

4,2'-Dihydroxy-4'-methoxychalcone	Others	Inflammation/Immunology
4,2'-Dihydroxy-4'-methoxychalcone, a chalcone, shows allergy-preventive effects .

HY-115956

Tubulin inhibitor 18	Microtubule/Tubulin	Cancer
Tubulin inhibitor 18 (compound 5j) is a potent inhibitor of tubulin. Tubulin inhibitor 18 is a chalcone compound. Tubulin inhibitor 18 has the potential for the research of cancer diseases .

HY-115957

Tubulin inhibitor 19	Microtubule/Tubulin	Cancer
Tubulin inhibitor 19 (compound 9b) is a potent inhibitor of tubulin. Tubulin inhibitor 19 is an indole chalcone compound. Tubulin inhibitor 19 has the potential for the research of cancer diseases .

HY-N7557

(E)-2'-Hydroxy-3,4-dimethoxychalcone	Others	Cancer
(E)-2'-Hydroxy-3,4-dimethoxychalcone (compound 7) is a Chalcone derivative with orally active. (E)-2'-Hydroxy-3,4-dimethoxychalcone has anti-tumour activities .

HY-115970

Tubulin inhibitor 21	Microtubule/Tubulin	Cancer
Tubulin inhibitor 21 (compound 6f), a chalcone- and melatonin- based hybrid, is a potent tubulin inhibitor. Tubulin inhibitor 21 induces a remarkable cytotoxic activity toward SW480 cells (IC₅₀=0.26 μM) with lower effect against nonmalignant cells .

HY-N7591

Millepachine	Apoptosis	Cancer
Millepachine is a bioactive natural chalcone from Chinese herbal medicine Millettia pachycarpa Benth, exhibits strong antitumor effects against numerous human cancer cells both in vitro and in vivo .

HY-N2420

Flavokawain A 1 Publications Verification	Apoptosis	Cancer
Flavokawain A, a proming anticarcinogenic agent, is a chalcone from kava extract with anti-tumor activity. Flavokawain A induces cell apoptosis by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway. Flavokawain A has the potential for the study of bladder cancer .

HY-148568

TMV-IN-2	TMV Bacterial	Infection Inflammation/Immunology Cancer
TMV-IN-2, chalcone derivative, is a tobacco mosaic virus (TMV) inhibitor. TMV-IN-2 has antiviral activity against TMV with an EC₅₀ value of 89.9 μg/mL. TMV-IN-2 can be used for the research of infection, inflammation and tumor .

HY-148569

TMV-IN-3	TMV Bacterial	Infection Inflammation/Immunology Cancer
TMV-IN-3, chalcone derivative, is a tobacco mosaic virus (TMV) inhibitor. TMV-IN-3 has antiviral activity against TMV with an EC₅₀ value of 120.3 μg/mL. TMV-IN-3 can be used for the research of infection, inflammation and tumor .

HY-N8707

Homobutein	Parasite HDAC NF-κB	Infection Inflammation/Immunology Cancer
Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC₅₀s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation .

HY-148567

TMV-IN-1	TMV Bacterial	Infection Inflammation/Immunology Cancer
TMV-IN-1, chalcone derivative, is a tobacco mosaic virus (TMV) inhibitor. TMV-IN-1 has good therapeutic activity and protective activity against TMV with EC₅₀ values of 70.7 μg/mL and 60.8 μg/mL, respectively. TMV-IN-1 can be used for the research of infection, inflammation and tumor .

HY-N7056

4'-Hydroxychalcone	Oxidative Phosphorylation Proteasome	Inflammation/Immunology Cancer
4'-Hydroxychalcone is a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria .

HY-N12422

A2AAR antagonist 2	Adenosine Receptor	Inflammation/Immunology Cancer
3′-Methoxyfurano[4″,5″:3,4]chalcone (compound 2) is a selective A_2AAR antagonist (IC₅₀=33.5 nM) with high affinity. 3′-Methoxyfurano[4″,5″:3,4]chalcone is also a natural product obtained from the bark of Allium cepa L. 3′-Methoxyfurano[4″,5″:3,4]chalcone can promote T cell activation and can be used in cancer immunity research .

HY-107412

Proteasome inhibitor IX PS-IX; AM114	Proteasome	Cancer
Proteasome inhibitor IX (PS-IX; AM114) is a Chalcone derivative and a chymotrypsin-like activity of the 20S proteasome inhibitor with an IC₅₀ value of ~1 μM. Proteasome inhibitor IX exhibits HCT116 p53 ^+/+ cells growth inhibitory activity with an IC₅₀ value of 1.49 μM. Proteasome inhibitor IX has potent anticancer activity .

HY-N0279

Cardamonin Maximum Cited Publications 9 Publications Verification Cardamomin; Alpinetin Chalcone	NF-κB STAT Wnt β-catenin Bcl-2 Family Apoptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities .

HY-148114

MOPIPP	Others	Cancer
MOPIPP is a novel indolebased chalcone, and vacuolin-1, is a non-lethal vacuoleinducing 2-propyl analog of MOMIPP (HY-148114). MOPIPP induces cellular vacuolization and increases autophagosomes numbers. MOPIPP also triggers methuosis, and interrupts glucose uptake and glycolytic metabolism. MOPIPP can cross the blood-brain barrier and shows efficacy in suppressing tumor progression agaisnt glioblastoma cells .

HY-119833

Rubone	MicroRNA	Cancer
Rubone, a chalcone analog, is a modulator of miR-34a. Rubone upregulates miR-34a expression in a p53 dependent manner, downregulates the downstream target Bcl-2 and Cyclin D1 expression, and suppresses hepatocellular carcinoma (HCC) growth in vivo. Rubone enhances the anticancer effect of Paclitaxel (PTX; HY-B0015) in PTX-resistant prostate cancer cell lines by reversing the expression of miR-34a downstream targets .

HY-145104

Antioxidant agent-1

Others Others

Antioxidant agent-1 is a new chalcone derivative as a potential antioxidant agent.

Antioxidant agent-1	Others	Others
Antioxidant agent-1 is a new chalcone derivative as a potential antioxidant agent.

HY-16558

Butein 3 Publications Verification 2’,3,4,4’-tetrahydroxy Chalcone	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)	Cancer
Butein is a cAMP-specific PDE inhibitor with an IC₅₀ of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC₅₀s of 16 and 65 μM for EGFR and p60 ^c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).

HY-N1378

(E)-Cardamonin 1 Publications Verification (E)-Cardamomin; (E)-Alpinetin Chalcone	TRP Channel Apoptosis	Neurological Disease Cancer
(E)-Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC₅₀ of 454 nM.

HY-N1745A

3-Deoxysappanchalcone 1 Publications Verification	Influenza Virus	Infection Inflammation/Immunology
3-Deoxysappanchalcone is a naturally-occurring chalcone compound isolated from Caesalpinia sappan L.

HY-N11766

Calythropsin

Others Cancer

Calythropsin is a cytotoxic chalcone, with weak effect on mitosis, and presumably also on tubulin polymerization .

Calythropsin	Others	Cancer
Calythropsin is a cytotoxic chalcone, with weak effect on mitosis, and presumably also on tubulin polymerization .

HY-N0154

Neohesperidin dihydrochalcone 1 Publications Verification Neohesperidin DC; NHDC	Reactive Oxygen Species	Inflammation/Immunology
Neohesperidin dihydrochalcone is a synthetic glycoside chalcone, is added to various foods and beverages as a low caloric artificial sweetener.

HY-128452

2'-Hydroxy-2-methoxychalcone

Bacterial Infection Inflammation/Immunology

2'-Hydroxy-2-methoxychalcone (compound 3b) is a synthetic chalcone, with antimicrobial activity .
HY-N11129

3',4,4',6-Tetrahydroxyaurone 4-O-β-D-glucoside

Others Others

3',4,4',6-Tetrahydroxyaurone 4-O-β-D-glucoside is a chalcone glucoside that can be found in Acacia dealbata .

2'-Hydroxy-2-methoxychalcone	Bacterial	Infection Inflammation/Immunology
2'-Hydroxy-2-methoxychalcone (compound 3b) is a synthetic chalcone, with antimicrobial activity .

3',4,4',6-Tetrahydroxyaurone 4-O-β-D-glucoside	Others	Others
3',4,4',6-Tetrahydroxyaurone 4-O-β-D-glucoside is a chalcone glucoside that can be found in Acacia dealbata .

HY-N2445

Flavokawain C 1 Publications Verification	Apoptosis	Cancer
Flavokawain C is a natural chalcone found in Kava root. Flavokawain C exerts cytotoxicity against human cancer cell lines, with an IC₅₀ of 12.75 μM for HCT 116 cells .

HY-N1910

4'-O-Methylbavachalcone 1 Publications Verification
4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity, with an IC₅₀ of 10.1 μM .

HY-N0269

Echinatin 2 Publications Verification	Apoptosis Autophagy NOD-like Receptor (NLR)	Cardiovascular Disease Inflammation/Immunology Cancer
Echinatin is a chalcone isolated from the Chinese herbal medicine Gancao with hepatoprotective and anti-inflammatory effects . Echinatin can be quickly absorbed and eliminated and extensively distributed with an absolute bioavailability of approximately 6.81% in Rat .

HY-N5106

(E)-Flavokawain A	Apoptosis	Cancer
(E)-Flavokawain A, a chalcone extracted from Kava, has anticarcinogenic effect. (E)-Flavokawain A induces apoptosis in bladder cancer cells by involvement of bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice .

HY-N1664

2',4'-Dihydroxy-2,3',6'-trimethoxychalcone	Others	Others
2',4'-Dihydroxy-2,3',6'-trimethoxychalcone, a flavonoid, is a natural product that can be isolated from the roots of Scutellaria Luzonicatropical .

HY-161143

Carbonic anhydrase/AChE-IN-2	Cholinesterase (ChE) Carbonic Anhydrase	Neurological Disease
Carbonic anhydrase/AChE-IN-2 (compound 19) is a selective acetylcholinesterase (AChE) and carbonic anhydrase (CA) inhibitor, with E_i of 5.07 nM, 24.42 nM and 19.95 nM for AChE, hCAI and hCAII, respectively .

HY-157405

DENV-IN-11	Dengue virus	Infection
DENV-IN-11 (SC27), a sulfonamide chalcone, is a potent DENV inhibitor that targeted viral methyltransferase. DENV-IN-11 reduced DENV2 replicon replication. DENV-IN-11 can be used for dengue infection research .

HY-124345

2-Trifluoromethyl-2'-methoxychalcone	Keap1-Nrf2	Inflammation/Immunology
2-Trifluoromethyl-2'-methoxychalcone is a chalcone derivative. 2-Trifluoromethyl-2'-methoxychalcone is a potent Nrf2 activator. 2-Trifluoromethyl-2'-methoxychalcone can be used for oxidative stress and inflammation related diseases research .

HY-N10077

Eriosemation

Lupichromone
Others Others

Eriosemation is a chromone derivatives that can be isolated from Flemingia philippinensis .

Eriosemation Lupichromone	Others	Others
Eriosemation is a chromone derivatives that can be isolated from Flemingia philippinensis .

HY-N7516

4'-Hydroxy-2,4-dimethoxychalcone	Parasite Bacterial Fungal	Infection
4'-Hydroxy-2,4-dimethoxychalcone is a natural chalcone derivatives in the red herbal resin of Dracaena cochinchinensis. 4'-Hydroxy-2,4-dimethoxychalcone displays a wide range of biological activities including antimalarial, antiprotozoal, antibacterial, antifungal activity .

HY-126382

Hesperidin methylchalcone 1 Publications Verification	NF-κB	Inflammation/Immunology
Hesperidin methylchalcone (Hesperidin methyl chalcone) is an orally active flavonoid that has analgesic, anti-inflammatory and antioxidant properties. Hesperidin methylchalcone exhibits vasoprotective activity. Hesperidin methylchalcone inhibits oxidative stress, cytokine production and NF-κB activation. Hesperidin methylchalcone can be used for the research of gout disease .

HY-N2208

4-Hydroxylonchocarpin 1 Publications Verification
4-Hydroxylonchocarpin is a chalcone compound from an extract of Psoralea corylifolia. 4-Hydroxylonchocarpin increases phosphorylation of p38 MAPK, JNK and ERK. 4-Hydroxylonchocarpin has diverse pharmacological activities, including antibacterial, antifungal, anticancer, antireverse transcriptase, antitubercular, antimalarial, anti-inflammatory and antioxidant activities .

HY-156288

Anti-Influenza agent 5	Influenza Virus	Infection
Anti-Influenza agent 5 (Compound IIB-2), chalcone-like derivative, is an influenza nuclear export inhibitor. Anti-Influenza agent 5 has inhibitory effects on oseltamivir-resistant strains. Anti-Influenza agent 5 can impede virus proliferation by blocking the export of influenza virus nucleoprotein .

HY-107818

4-Hydroxychalcone	NF-κB	Cardiovascular Disease Inflammation/Immunology
4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity . 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice .

HY-N2132

Flavokawain B 1 Publications Verification Flavokavain B	Apoptosis	Cancer
Flavokawain B (Flavokavain B) is a chalcone isolated from the root extracts of kava-kava plant and a potent apoptosis inducer for inhibiting the growth of various cancer cell lines. Flavokawain B (Flavokavain B) shows strong antiangiogenic activity. Flavokawain B (Flavokavain B) inhibits human brain endothelial cell (HUVEC) migration and tube formation with very low and non-toxic concentrations .

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