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Chlorinated

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Antibiotic (1) Drug Metabolite (1) Endogenous Metabolite (1) GABA Receptor (1) Isotope-Labeled Compounds (1) Melatonin Receptor (1) NF-κB (1) Parasite (1) Potassium Channel (1) STAT (1)
By Research Areas:	Cancer (4) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7535

Chlorovaltrate K	Others	Cancer
Chlorovaltrate K is a chlorinated valepotriate with anticancer effects. Chlorovaltrate K shows moderate cytotoxicity against A549, PC-3M, HCT-8 and Bel 7402 cell lines with IC₅₀ values of 2.32-8.26 μM .

HY-133621

9,10-Dichlorostearic acid	Others	Cancer
9,10-Dichlorostearic acid is a chlorinated stearic acid with antimutagenic properties. 9,10-Dichlorostearic acid can cause membrane damage by inducing leakage of adenosine triphosphate (ATP) from mammalian tumour cells in vitro .

HY-133596

12,14-Dichlorodehydroabietic acid	Potassium Channel GABA Receptor	Neurological Disease
12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca ²⁺-activated K ⁺ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABA_A antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca ²⁺ and stimulates transmitter release .

HY-106136

TIK-301 PD-6735; LY-156735	Melatonin Receptor 5-HT Receptor	Neurological Disease
TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT₁ and MT₂ receptors agonist with K_is of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a 5-HT_2B/5-HT_2C receptors antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment .

HY-133599

4,5-Dichloroguaiacol

Others Others

4,5-Dichloroguaiacol is the major component of chlorinated phenol .
HY-133602

Tetrachloroguaiacol

Others Others

Tetrachloroguaiacol is the major chlorinated phenol produced during chlorine bleaching of wood pulp .
HY-133606

3,4,5-Trichlorosyringol

Others Others

3,4,5-Trichlorosyringol is a chlorophenolic compound synthetised by chlorination of syringol in carbon disulphide (CS₂) .

4,5-Dichloroguaiacol	Others	Others
4,5-Dichloroguaiacol is the major component of chlorinated phenol .

Tetrachloroguaiacol	Others	Others
Tetrachloroguaiacol is the major chlorinated phenol produced during chlorine bleaching of wood pulp .

3,4,5-Trichlorosyringol	Others	Others
3,4,5-Trichlorosyringol is a chlorophenolic compound synthetised by chlorination of syringol in carbon disulphide (CS₂) .

HY-132183

Chloride peroxidase	Endogenous Metabolite	Metabolic Disease
Chloride peroxidase is a monomeric, heme-containing enzyme. Chloride peroxidase is capable of electrophilic chlorinations through the umpolung of chloride by oxidation with hydrogen peroxide .

HY-133603

4,5-Dichloroveratrole

Others Others

4,5-Dichloroveratrole is a chlorinated product formed by reaction of Veratryl alcohol (VE; HY-107858) with chlorine dioxide solution .

4,5-Dichloroveratrole	Others	Others
4,5-Dichloroveratrole is a chlorinated product formed by reaction of Veratryl alcohol (VE; HY-107858) with chlorine dioxide solution .

HY-N11494

Dauricumine	NF-κB	Others
Dauricumine is a chlorinated alkaloid that inhibits NF-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts .

HY-108712

TDCPP 4 Publications Verification Tris(1,3-dichloroisopropyl)phosphate	Others	Cancer
TDCPP is a chlorinated analog of tris(2,3-dibromopropyl)phosphate (Tris) which is one of the most detected organophosphorus flame retardants (OPFRs) in the environment.

HY-133607

5,6-Dichlorovanillin	Others	Others
5,6-Dichlorovanillin is a product upon chlorination to afford 4,5,6-trichloroguaiacol, together with tetrachloroguaiacol and the unreacted starting materials .

HY-W006000

Tetrachlorocatechol	Drug Metabolite	Others
Tetrachlorocatechol is a metabolite of pentachlorophenol. Tetrachlorocatechol is one of the most toxic chlorinated catechol produced by the chlorobleaching of pulp and frequently found in the kraft pulp mill effluents .

HY-133653

3,3-Dibromopropenoic acid 3,3-Dibromoacrylic acid	Others	Others
3,3-Dibromopropenoic acid is a 3,3-dibromo product based on propenoic acid. 3,3-Dibromopropenoic acid is a polar aromatic brominated disinfection byproduct during chlorination in water .

HY-133654

2,3,3-Tribromopropenoic acid	Others	Others
2,3,3-Tribromopropenoic acid is a 2,3,3-Tribromo product based on propenoic acid. 2,3,3-Tribromopropenoic acid is a polar aromatic brominated disinfection byproduct during chlorination in water and shows cytotoxic potency in mammalian cell chronic cytotoxicity experiments .

HY-B0497S1

Niclosamide-13C6 BAY2353-¹³C₆	Isotope-Labeled Compounds STAT Parasite Antibiotic	Infection Cancer
Niclosamide- ¹³C₆ is the ¹³C₆ labeled Niclosamide. Niclosamide (BAY2353) is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Niclosamide (BAY2353) inhibits STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free assay.

HY-N6937

(R,R)-Secoisolariciresinol diglucoside (R,R)-SDG; (R,R)-LGM2605	Others	Inflammation/Immunology
(R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6937

(R,R)-Secoisolariciresinol diglucoside (R,R)-SDG; (R,R)-LGM2605	Linum usitatissimum Linn. Classification of Application Fields Linaceae Source classification Lignans Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields	Others
(R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .

HY-N7535

Chlorovaltrate K	Structural Classification Valeriana jatamansi Jones Iridoids Terpenoids Source classification Plants Valerianaceae	Others
Chlorovaltrate K is a chlorinated valepotriate with anticancer effects. Chlorovaltrate K shows moderate cytotoxicity against A549, PC-3M, HCT-8 and Bel 7402 cell lines with IC₅₀ values of 2.32-8.26 μM .

HY-132183

Chloride peroxidase	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Chloride peroxidase is a monomeric, heme-containing enzyme. Chloride peroxidase is capable of electrophilic chlorinations through the umpolung of chloride by oxidation with hydrogen peroxide .

HY-N11494

Dauricumine	Structural Classification Alkaloids Source classification Plants Menispermaceae Menispermum dauricum Alkaloid Dimers	NF-κB
Dauricumine is a chlorinated alkaloid that inhibits NF-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts .

Cat. No.	Product Name	Chemical Structure

HY-B0497S1

Niclosamide-13C6
Niclosamide- ¹³C₆ is the ¹³C₆ labeled Niclosamide. Niclosamide (BAY2353) is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Niclosamide (BAY2353) inhibits STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free assay.

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Chlorinated

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Isotope-Labeled Compounds

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