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Chloroquine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (6) Apoptosis (2) Autophagy (15) Bacterial (1) CDK (1) Drug Metabolite (3) Histone Methyltransferase (1) HIV (7) Influenza Virus (4) Isotope-Labeled Compounds (7) mTOR (1) Parasite (27) PKA (1) SARS-CoV (8) Toll-like Receptor (TLR) (11)
By Research Areas:	Cancer (14) Cardiovascular Disease (2) Infection (29) Inflammation/Immunology (12)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17589A

*Chloroquine* Maximum Cited Publications 529 Publications Verification	Parasite Autophagy SARS-CoV Toll-like Receptor (TLR) HIV Antibiotic	Infection Inflammation/Immunology Cancer
Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC₅₀=1.13 μM) .

HY-17589AS

Chloroquine-d5 1 Publications Verification	Parasite Autophagy SARS-CoV Toll-like Receptor (TLR) HIV	Infection Inflammation/Immunology Cancer
Chloroquine-d₅ is deuterium labeled Chloroquine. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

HY-17589R

Chloroquine phosphate (Standard) 130+ Cited Publications	Parasite Autophagy SARS-CoV Toll-like Receptor (TLR) HIV Antibiotic	Infection Inflammation/Immunology Cancer
Chloroquine (phosphate) (Standard) is the analytical standard of Chloroquine (phosphate). This product is intended for research and analytical applications. Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC₅₀=1.13 μM) .

HY-W614112

(-)-Chloroquine

Others Others

(-)-Chloroquine is a chloroquine enantiomer .

(-)-Chloroquine	Others	Others
(-)-Chloroquine is a chloroquine enantiomer .

HY-17589S1

Chloroquine-d4 phosphate	Isotope-Labeled Compounds Parasite Autophagy SARS-CoV Toll-like Receptor (TLR) HIV Antibiotic	Infection Inflammation/Immunology Cancer
Chloroquine-d₄ (phosphate) is the deuterium labeled Chloroquine phosphate. Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

HY-17589

Chloroquine phosphate Maximum Cited Publications 529 Publications Verification	Parasite Autophagy SARS-CoV Toll-like Receptor (TLR) HIV Antibiotic	Infection Inflammation/Immunology Cancer
Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC₅₀=1.13 μM) .

HY-17589B

Chloroquine dihydrochloride	Parasite Autophagy SARS-CoV Toll-like Receptor (TLR) HIV Antibiotic	Infection Inflammation/Immunology Cancer
Chloroquine dihydrochloride is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine dihydrochloride is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine dihydrochloride is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC₅₀=1.13 μM) .

HY-17589S

Chloroquine-d5 diphosphate	Isotope-Labeled Compounds Parasite Autophagy SARS-CoV Toll-like Receptor (TLR) HIV Antibiotic	Infection Inflammation/Immunology Cancer
Chloroquine-d₅ (diphosphate) is the deuterium labeled Chloroquine (phosphate). Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

HY-100662

Didesethyl chloroquine BisdesethylChloroquine	Drug Metabolite	Cardiovascular Disease
Didesethyl chloroquine (Bisdesethylchloroquine) is a major metabolite of the antimalarial agent Chloroquine. Didesethyl chloroquine is a potent myocardial depressant .

HY-135811

Desethyl chloroquine 1 Publications Verification	Parasite Toll-like Receptor (TLR) Autophagy	Infection
Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity .

HY-135811A

*Desethyl chloroquine* diphosphate** 1 Publications Verification	Parasite Toll-like Receptor (TLR) Autophagy	Infection
Desethyl chloroquine diphosphate is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine diphosphate possesses antiplasmodic activity .

HY-156862

(+)-Chloroquine

Others Others

(+)-Chloroquine is a aminoquinoline drug impairs in vitro the terminal glycosylation of angiotensin-converting enzyme 2 (ACE-2) .

(+)-Chloroquine	Others	Others
(+)-Chloroquine is a aminoquinoline drug impairs in vitro the terminal glycosylation of angiotensin-converting enzyme 2 (ACE-2) .

HY-135811S

*Desethyl chloroquine-d4*	Isotope-Labeled Compounds Parasite Toll-like Receptor (TLR) Autophagy	Infection
Desethyl chloroquine-d₄ is the deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2].

HY-135811S1

*Desethyl chloroquine-d5*	Isotope-Labeled Compounds Parasite Toll-like Receptor (TLR) Autophagy	Infection
Desethyl chloroquine-d₅ is deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2].

HY-100662S

*Didesethyl chloroquine-d4* BisdesethylChloroquine-d₄	Isotope-Labeled Compounds Drug Metabolite	Cardiovascular Disease
Didesethyl chloroquine-d₄ is the deuterium labeled Didesethyl chloroquine. Didesethyl chloroquine (Bisdesethylchloroquine) is a major metabolite of the antimalarial agent Chloroquine. Didesethyl chloroquine is a potent myocardial depressant[1][2].

HY-N2932

β-Yohimbine Amsonin; Amsonine; NSC 93133	Parasite	Infection
β-Yohimbine (Amsonin) is an indole alkaloid that can be isolated from Aspidosperma ulei Markgr. β-Yohimbine shows antiplasmodial activity against the Chloroquine (HY-17589A)-resistant Fc M29-Cameroon strain (IC₅₀: > 1 μg/mL) .

HY-12855

Lys01	Autophagy	Cancer
Lys01, a dimeric form of Chloroquine (HY-17589A), is an autophagy inhibitor. Lys01 inhibits cell viability of 1205Lu, c8161, LN229, HT-29 cells with IC₅₀s of 3.6, 3.8, 7.9, 6.0 μM. Lys01 can be used for anticancer research .

HY-146769

Antimalarial agent 11	Parasite	Infection
Antimalarial agent 11 (compound 1), a spirocyclic chromane, is a potent antimalarial agent. Antimalarial agent 11 exhibits excellent potency with an EC₅₀ of 350 nM against the Chloroquine-resistant Dd2 strain. Antimalarial agent 11 has EC₅₀s of 1.48 µM and 1.81 µM against D6 and ARC08-022 strains, respectively .

HY-118865

Piperaquine tetraphosphate	Parasite	Infection
Piperaquine tetraphosphate is a potent antimalaria agent. Piperaquine tetraphosphate shows inhibition for chloroquine-sensitive and the chloroquine-resistant isolates. Piperaquine tetraphosphate in combination with dihydroartemisinin has the potential for the research of chloroquine-resistant malaria .

HY-149960

Antiparasitic agent-17	Parasite	Infection
Antiparasitic agent-17 (compound 5u) is an orally active antiparasitic agent. Antiparasitic agent-17 inhibits Chloroquine sensitive (Pf3D7) and Chloroquine resistant (PfK1) strain with IC₅₀s of 0.96 μM and 1.67 μM, respectively .

HY-N1074

Warangalone Scandenolone	Parasite PKA	Infection Inflammation/Immunology
Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC₅₀s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC₅₀ of 3.5 μM.

HY-19364

Ferroquine 2 Publications Verification FerroChloroquine; SSR97193	Parasite	Infection
Ferroquine (Ferrochloroquine), a ferrocenyl analogue of Chloroquine, is an antimalarial agent. Ferroquine shows parasiticidal effect on *Plasmodium* by inducing oxidative stress and the subsequent destruction of the membrane .

HY-17036

Naphthoquine phosphate	Parasite	Infection
Naphthoquine phosphate is a potent and orally active antimalarial agent. Naphthoquine phosphate has thorough killing function for various schizonts of plasmodia, including resistance of *P. falciparum* to Chloroquine .

HY-A0148

Halofantrine SKF-102886 free base; WR-171669
Halofantrine (SKF-102886 free base) is a highly lipophilic antimalarial active against Chloroquine-resistant strains of Plasmodium falciparum . Halofantrine blocks HERG potassium channels .

HY-135847

Desmethyl ferroquine SSR97213	Parasite Drug Metabolite	Infection
Desmethyl ferroquine (SSR97213) is the active and major metabolite of Ferroquine. Ferroquine is an antimalarial. Desmethyl ferroquine shows significant activity against Chloroquine-susceptible and resistant P. falciparum strains .

HY-163070

Antimalarial agent 35	Others	Infection
Antimalarial agent 35 (compound QP11) is a selective inhibitor FP2. Antimalarial agent 35 has antimalarial activity and shows synergistic effects when combined with chloroquine(HY-17589A) .

HY-B0770

Artemotil β-Arteether; (+)-Arteether; Arteether	Parasite	Infection Cancer
Artemotil (β-Arteether) has antimalarial activity for the treatment of chloroquine-resistant *Plasmodium falciparum* malaria with an IC₅₀ of 1.61 nM. Artemotil also has central nervous system (CNS) neurotoxicity and anorectic toxicity in rats, dogs and monkeys .

HY-P1182

C21

Histone Methyltransferase Cancer

C21 is a potent, irreversible, and selective PRMT1 inhibitor with an IC₅₀ of 1.8 μM. C21 inhibits PRMT6 with an IC₅₀ of 8.8 μM .

C21	Histone Methyltransferase	Cancer
C21 is a potent, irreversible, and selective PRMT1 inhibitor with an IC₅₀ of 1.8 μM. C21 inhibits PRMT6 with an IC₅₀ of 8.8 μM .

HY-P4307

Antioxidant agent-9	SARS-CoV	Infection
Antioxidant agent-9 is a peptide with the sequence Asp-Trp. Antioxidant agent-9 shows antioxidant activity. Antioxidant agent-9 also is potential as SARS-CoV-2 antiviral, with an affinity strength equal to Chloroquine (HY-17589A) and Favipiravir (HY-14768) .

HY-135810

Cletoquine DesethylhydroxyChloroquine	Influenza Virus Parasite	Infection Inflammation/Immunology
Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment .

HY-135810A

Cletoquine oxalate DesethylhydroxyChloroquine oxalate	Influenza Virus Parasite	Infection Inflammation/Immunology
Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment .

HY-135810S

Cletoquine-d4 DesethylhydroxyChloroquine-d₄	Isotope-Labeled Compounds Influenza Virus Parasite	Infection Inflammation/Immunology
Cletoquine-d₄ is deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].

HY-135810S1

Cletoquine-d4-1 DesethylhydroxyChloroquine-d₄-1	Isotope-Labeled Compounds Influenza Virus Parasite	Infection Inflammation/Immunology
Cletoquine-d₄-1 is the deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].

HY-155845

Antileishmanial agent-21	Parasite	Infection
Antileishmanial agent-21 (compound 4e) is an antileishmanial agent that targets the Leishmania pteridine reductase 1 (Lm-PTR1). Antileishmanial agent-21 has an anti-folate mechanism, and folic acid and leucovorin can reverse the anti-leishmanial activity of Antileishmanial agent-21. Antileishmanial agent-21 inhibits the Chloroquine (HY-17589A)-resistant strain of Plasmodium falciparum (RKL9) with an IC₅₀ of 0.0198-0.096 μM .

HY-103691A

ARN5187 trihydrochloride	Autophagy Apoptosis	Cancer
ARN5187 trihydrochloride is a lysosomotropic REV-ERBβ ligand with a dual inhibitory activity toward REV-ERB-mediated transcriptional regulation and autophagy. ARN5187 trihydrochloride shows lysosomotropic potency and cytotoxicity. ARN5187 trihydrochloride induces apoptosis .

HY-103691

ARN5187	Autophagy Apoptosis	Cancer
ARN5187 is a lysosomotropic REV-ERBβ ligand with a dual inhibitory activity toward REV-ERB-mediated transcriptional regulation and autophagy. ARN5187 shows lysosomotropic potency and cytotoxicity. ARN5187 induces apoptosis .

HY-124582

NEO214	Autophagy mTOR	Cancer
NEO214 is an autophagy inhibitor and a covalent conjugate of the PDE4 inhibitor Rolipram (HY-16900) and perillyl alcohol (HY-N7000). It has anti-cancer activity and blood-brain barrier (BBB) permeability. Over sex. NEO214 prevents autophagy-lysosome fusion, thereby blocking autophagic flux and triggering glioma cell death. The process involves mTOR activation, andTFEB(Transcription Factor EB) aggregation. NEO214 inhibitionMacroautophagy/autophagy in glioblastoma cells has the potential to overcome chemotherapy resistance in glioblastoma .

HY-18299

Purvalanol B 1 Publications Verification NG 95	CDK Parasite	Infection Cancer
Purvalanol B (NG 95) is a potent, selective, reversible and ATP-competitive inhibitor CDK, with IC₅₀s of 6 nM, 6 nM, 9 nM, 6 nM for cdc2-cyclin B, CDK2-cyclin A, CDK2-cyclin E and CDK5-p35, respectively. Purvalanol B shows selectivity for CDK over a range of other protein kinases (IC₅₀>1000 nM). Purvalanol B inhibits the growth a chloroquine-resistant strain of P. falciparum .

HY-148180

Antimycobacterial agent-4	Bacterial Parasite	Infection
Antimycobacterial agent-4 is a 2-amino-4-(2-pyridyl) thiazole derivative, with antimycobacterial activity, antiplasmodial activity, and cytotoxicity on a mammalian cell line .

C21	Histone Methyltransferase	Cancer
C21 is a potent, irreversible, and selective PRMT1 inhibitor with an IC₅₀ of 1.8 μM. C21 inhibits PRMT6 with an IC₅₀ of 8.8 μM .

Antioxidant agent-9	SARS-CoV	Infection
Antioxidant agent-9 is a peptide with the sequence Asp-Trp. Antioxidant agent-9 shows antioxidant activity. Antioxidant agent-9 also is potential as SARS-CoV-2 antiviral, with an affinity strength equal to Chloroquine (HY-17589A) and Favipiravir (HY-14768) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0770

Artemotil β-Arteether; (+)-Arteether; Arteether	Natural Products Classification of Application Fields Source classification Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae Disease Research Fields Cancer	Parasite
Artemotil (β-Arteether) has antimalarial activity for the treatment of chloroquine-resistant *Plasmodium falciparum* malaria with an IC₅₀ of 1.61 nM. Artemotil also has central nervous system (CNS) neurotoxicity and anorectic toxicity in rats, dogs and monkeys .

HY-N2932

β-Yohimbine Amsonin; Amsonine; NSC 93133	Apocynaceae Rauvolfia verticillata (Lour.) Baill. Structural Classification Alkaloids Aspidosperma ulei Markgr. Source classification Plants Indole Alkaloids	Parasite
β-Yohimbine (Amsonin) is an indole alkaloid that can be isolated from Aspidosperma ulei Markgr. β-Yohimbine shows antiplasmodial activity against the Chloroquine (HY-17589A)-resistant Fc M29-Cameroon strain (IC₅₀: > 1 μg/mL) .

HY-N1074

Warangalone Scandenolone	Structural Classification Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Isoflavones Erythrina variegata Linn.	Parasite PKA
Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC₅₀s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC₅₀ of 3.5 μM.

Cat. No.	Product Name	Chemical Structure

HY-17589AS

Chloroquine-d5 1 Publications Verification
Chloroquine-d₅ is deuterium labeled Chloroquine. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

HY-17589S1

Chloroquine-d4 phosphate

Chloroquine-d₄ (phosphate) is the deuterium labeled Chloroquine phosphate. Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

HY-17589S

Chloroquine-d5 diphosphate

Chloroquine-d₅ (diphosphate) is the deuterium labeled Chloroquine (phosphate). Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

HY-135811S

*Desethyl chloroquine-d4*
Desethyl chloroquine-d₄ is the deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2].

HY-135811S1

*Desethyl chloroquine-d5*
Desethyl chloroquine-d₅ is deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2].

HY-100662S

*Didesethyl chloroquine-d4*
Didesethyl chloroquine-d₄ is the deuterium labeled Didesethyl chloroquine. Didesethyl chloroquine (Bisdesethylchloroquine) is a major metabolite of the antimalarial agent Chloroquine. Didesethyl chloroquine is a potent myocardial depressant[1][2].

HY-135810S

Cletoquine-d4

Cletoquine-d₄ is deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].

HY-135810S1

Cletoquine-d4-1

Cletoquine-d₄-1 is the deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].

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