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Cpla2 Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Biochemical Assay Reagents (1) Endogenous Metabolite (2) FAAH (1) MAGL (1) Phosphatase (1) Phospholipase (13)
By Research Areas:	Cancer (4) Cardiovascular Disease (4) Inflammation/Immunology (10) Metabolic Disease (2) Neurological Disease (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas

HY-N0134

Tanshinone I 1 Publications Verification Tanshinone A	Phospholipase	Cardiovascular Disease Cancer
Tanshinone I is an inhibitor of type IIA human recombinant sPLA₂ (IC₅₀=11 μM) and rabbit recombinant *cPLA₂* (IC₅₀=82 μM).

HY-103334

MAFP Methyl Arachidonyl Fluorophosphonate	Phospholipase	Metabolic Disease Neurological Disease Cardiovascular Disease
MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, active-site directed and irreversible inhibitor of *cPLA2* and iPLA2. MAFP is also a potent irreversible inhibitor of anandamide amidase.

HY-W127380

Arachidonoyl thio-PC	Biochemical Assay Reagents	Others
Arachidonoyl Thio-PC is a substrate of many phospholipase A2 (PLA2), including sPLA2, cPLA2 and iPLA2. Cleavage of sn-2 fatty acids by PLA2 results in the production of free thiols, which react with chromogenic reagents such as DTNB (Ellman's reagent) and DTP, allowing quantification of PLA2 activity. Isozyme-specific cPLA2 activity can be measured by depleting or inhibiting sPLA2 and iPLA2 activity in the assay.

HY-14952

Giripladib PLA-695	Phospholipase	Cancer Inflammation/Immunology
Giripladib (PLA-695) is a indole-based inhibitor of cytosolic phospholipase A₂ (cPLA₂). Giripladib can be used for osteoarthritis and breast cancer research.

HY-138990

GK563	Phospholipase Apoptosis	Inflammation/Immunology
GK563 is a selective Ca²⁺-independent phospholipase A₂ (GVIA iPLA₂) inhibitor with an IC₅₀ value of 1 nM. GK563 is 22000 times more active against GVIA iPLA₂ than GIVA cPLA₂. GK563 reduces β-cell apoptosis induced by proinflammatory cytokines, raising the possibility that it can be beneficial in countering autoimmune diseases, such as type 1 diabetes.

HY-108611

AACOCF3 1 Publications Verification Arachidonyl trifluoromethyl ketone	Phospholipase	Cardiovascular Disease
AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease.

HY-18540

KT109	MAGL	Metabolic Disease Inflammation/Immunology
KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC₅₀ of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGLα. KT109 shows inhibitory activity against PLA2G7 (IC₅₀=1 µM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-arachidonoylglycerol (2-AG), arachidonic acid and eicosanoids in mouse peritoneal macrophages.

HY-149654

FAAH/cPLA2α-IN-1

Phospholipase FAAH Inflammation/Immunology Neurological Disease

FAAH/cPLA2α-IN-1 is a dual inhibitor of FAAH and cPLA2α with IC₅₀s of 32 and 47 nM, respectively.
HY-W019838

D-Erythro-dihydrosphingosine

Endogenous Metabolite Phospholipase Cancer

D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A₂α (cPLA₂α) activity.
HY-106253

Efipladib

Phospholipase Inflammation/Immunology

Efipladib is a potent, selective and orally active cPLA₂α inhibitor with an IC₅₀ of 0.04 μM and a K_d of 0.067 μM.

FAAH/cPLA2α-IN-1	Phospholipase FAAH	Inflammation/Immunology Neurological Disease
FAAH/cPLA2α-IN-1 is a dual inhibitor of FAAH and *cPLA2α* with IC₅₀s of 32 and 47 nM, respectively.

D-Erythro-dihydrosphingosine	Endogenous Metabolite Phospholipase	Cancer
D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A₂α (cPLA₂α) activity.

Efipladib	Phospholipase	Inflammation/Immunology
Efipladib is a potent, selective and orally active *cPLA₂α* inhibitor with an IC₅₀ of 0.04 μM and a K_d of 0.067 μM.

HY-111376

Pyrrophenone 2 Publications Verification	Phospholipase	Inflammation/Immunology Cardiovascular Disease
Pyrrophenone is a potent and specific cytosolic phospholipase A₂α (cPLA₂α) inhibitor with an IC₅₀ value of 4.2 nM.

HY-119019

ASB14780

Phosphatase Inflammation/Immunology

ASB14780 is a 4-phenoxy derivative, the cytosolic Phospholipase A₂α (cPLA₂α) inhibitor, with an IC₅₀ value of 20 nM.

ASB14780	Phosphatase	Inflammation/Immunology
ASB14780 is a 4-phenoxy derivative, the cytosolic Phospholipase A₂α (cPLA₂α) inhibitor, with an IC₅₀ value of 20 nM.

HY-W019838S

D-Erythro-dihydrosphingosine-d7	Endogenous Metabolite Phospholipase	Cancer
D-Erythro-dihydrosphingosine-d₇ is the deuterium labeled D-Erythro-dihydrosphingosine. D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.

HY-10801

CAY10650 5 Publications Verification	Phospholipase	Inflammation/Immunology
CAY10650 is a highly potent cytosolic phospholipase A2α *(cPLA2α)* inhibitor with an IC₅₀ value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion.

HY-U00037

Ecopladib PLA 725	Phospholipase	Inflammation/Immunology
Ecopladib is a sub-micromolar inhibitor of cytosolic phospholipase A2α (cPLA2α), with IC₅₀s of 0.15 μM and 0.11 μM in the GLU micelle and rat whole blood assays, respectively.

HY-116301

CAY10502	Phospholipase	Inflammation/Immunology
CAY10502 is a potent, calcium-dependent cytosolic phospholipase A2 α (cPLA₂α) inhibitor with an IC₅₀ of 4.3 nM for isolated enzyme. CAY10502 can be used in the research of retinopathy and inflammatory diseases.

Cat. No.	Product Name	Type

Arachidonoyl thio-PC	Biochemical Assay Reagents
Arachidonoyl Thio-PC is a substrate of many phospholipase A2 (PLA2), including sPLA2, cPLA2 and iPLA2. Cleavage of sn-2 fatty acids by PLA2 results in the production of free thiols, which react with chromogenic reagents such as DTNB (Ellman's reagent) and DTP, allowing quantification of PLA2 activity. Isozyme-specific cPLA2 activity can be measured by depleting or inhibiting sPLA2 and iPLA2 activity in the assay.

Cat. No.	Product Name	Target	Category

Tanshinone I 1 Publications Verification Tanshinone A	Phospholipase	Terpenoids Diterpenoids Classification of Application Fields Disease Research Fields Cancer Source classification Plants Labiatae Hemistepta lyrata
Tanshinone I is an inhibitor of type IIA human recombinant sPLA₂ (IC₅₀=11 μM) and rabbit recombinant *cPLA₂* (IC₅₀=82 μM).

D-Erythro-dihydrosphingosine	Endogenous Metabolite Phospholipase	Structural Classification Natural Products Endogenous metabolite Source classification Disease Research Fields Cancer Classification of Application Fields
D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A₂α (cPLA₂α) activity.

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Cpla2 Inhibitors

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Natural
Products