Cu | MedChemExpress (MCE) Life Science Reagents

By Targets:	5-HT Receptor (1) ADC Linker (4) Aldehyde Dehydrogenase (ALDH) (1) Amyloid-β (4) Apoptosis (5) Bacterial (1) Biochemical Assay Reagents (1) Btk (1) Cannabinoid Receptor (1) Cholinesterase (ChE) (4) Cuproptosis (5) DGK (2) Dopamine Receptor (1) Endogenous Metabolite (5) Fluorescent Dye (12) GSK-3 (1) HDAC (2) Interleukin Related (1) Isotope-Labeled Compounds (1) Liposome (1) Monoamine Oxidase (1) Orthopoxvirus (1) Pyroptosis (1) Reactive Oxygen Species (2) Sirtuin (1) SOD (1) Tau Protein (1) Toll-like Receptor (TLR) (9) Topoisomerase (1) Tyrosinase (1)
By Research Areas:	Cancer (17) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (12) Metabolic Disease (8) Neurological Disease (13)
Click Chemistry:	Labeling and Fluorescence Imaging (1) Azide (4) Tetrazine (3) Alkynes (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-156376

Cu(II)-Elesclomol	Cuproptosis Apoptosis Topoisomerase	Cancer
Cu(II)-Elesclomol is a Cu ²⁺ complex of Elesclomol (HY-12040). Cu(II)-Elesclomol induces cuproptosis. Cu(II)-Elesclomol also inducesapoptosis, causes a G1 cell cycle block and induces DNA double strand breaks in K562 cells. Cu(II)-Elesclomol also weakly inhibits DNA topoisomerase I. Cu(II)-Elesclomol has anticancer activity .

HY-139324

Cu(II)GTSM 1 Publications Verification	GSK-3 Amyloid-β	Neurological Disease
Cu(II)GTSM, a cell-permeable Cu-complex, significantly inhibits GSK3β. Cu(II)GTSM inhibits Amyloid-β oligomers (AβOs) and decreases tau phosphorylation. Cu(II)GTSM also decreases the abundance of Amyloid-β trimers. Cu(II)GTSM is a potential anticancer and antimicrobial agent .

HY-131945

CU-115 2 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
CU-115 is a potent TLR8 antagonist (IC₅₀=1.04 µM), and shows selective for TLR8 over TLR7 (IC₅₀=>50 µM). CU-115 decreases TNF-α and IL-1β production activated by R-848 in THP-1 cells .

HY-155946

CU06-1004 Sac-1004	Others	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
CU06-1004 (Sac-1004) is an orally active endothelial dysfunction blocker. CU06-1004 ameliorates endothelial dysfunction by inhibiting hyperpermeability and inflammation, and is potent in inhibiting vascular leakage and inflammation in various animal models, such as diabetic retinopathy, stroke, cancer, and inflammatory bowel disease. CU06-1004 ameliorates CDAA-induced mouse model of NASH. CU06-1004 also improves cardiac function .

HY-121638

CU-3	Apoptosis DGK	Inflammation/Immunology Cancer
CU-3 is the racemate of (5Z,2E)-CU-3. (5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC₅₀ value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a K_m value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells .

HY-147310

CU-CPD107	Toll-like Receptor (TLR)	Infection
CU-CPD107 is a potent, selective toll-like receptor 8 (TLR 8) agonist. CU-CPD107 inhibits TLR8 signaling. CU-CPD107 converts to synergistic agonist activities in the presence of ssRNA and induces TLR8 signaling. CU-CPD107 inhibits proinflammatory factor expression and avoids immune responses in the presence of ssRNA .

HY-163200

Cu(I) chelator 1	Others Cuproptosis	Neurological Disease
Cu(I) chelator 1 (Compound LH2) is a chelator which targets the Cu(I) redox state. Cu(I) chelator 1 prevents ROS production .

HY-110353

CU-T12-9 3 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
CU-T12-9 is a specific TLR1/2 agonist with EC₅₀ of 52.9 nM in HEK-Blue hTLR2 SEAP assay. CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and iNOS .

HY-112051

CU-CPT9b 1 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
CU-CPT9b is a specific TLR8 antagonist, with an IC₅₀ of 0.7 nM. CU-CPT9b shows high binding affinity towards TLR8 with a K_d of 21 nM .

HY-103147

Mesulergine hydrochloride Cu32-085 hydrochloride	5-HT Receptor Dopamine Receptor	Neurological Disease
Mesulergine (CU32-085) hydrochloride is a potent 5-HT2C antagonist and dopamine (DA) agonist. Mesulergine hydrochloride presentes hyperphagia. Mesulergine hydrochloride has the potential for the research of cognitive processes .

HY-112667

CU-CPT-9a

3 Publications Verification

Toll-like Receptor (TLR) Inflammation/Immunology

CU-CPT-9a is a specific TLR8 antagonist, with an IC₅₀ of 0.5 nM.

CU-CPT-9a 3 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
CU-CPT-9a is a specific TLR8 antagonist, with an IC₅₀ of 0.5 nM.

HY-108471

CU-CPT22 5+ Cited Publications	Toll-like Receptor (TLR)	Cancer
CU-CPT22 is a potent protein complex of toll-like receptor 1 and 2 (TLR1/2) inhibitor, and competes with the synthetic triacylated lipoprotein (Pam₃CSK₄) binding to TLR1/2 with a K_i of 0.41 µM. CU-CPT22 blocks Pam₃CSK₄-induced TLR1/2 activation with an IC₅₀ of 0.58 µM .

HY-101929

CU-CPT17e 3 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
CU-CPT17e is a potent multi-Toll-like receptor (TLR) agonist that activates TLR3, TLR8, and TLR9.

HY-112050

CU-CPT-8m

2 Publications Verification

TLR8-specific antagonist
Toll-like Receptor (TLR) Inflammation/Immunology

CU-CPT-8m is a specific TLR8 antagonist, with an IC₅₀ of 67 nM.

CU-CPT-8m 2 Publications Verification TLR8-specific antagonist	Toll-like Receptor (TLR)	Inflammation/Immunology
CU-CPT-8m is a specific TLR8 antagonist, with an IC₅₀ of 67 nM.

HY-108473

CU-CPT 4a 1 Publications Verification TLR3-IN-1	Toll-like Receptor (TLR)	Cancer
CU-CPT 4a (TLR3-IN-1) is a potent, highly selective TLR3 signaling inhibitor. CU-CPT 4a represses the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β .

HY-136476B

Cu(II) protoporphyrin IX	Others	Inflammation/Immunology Cancer
Cu (II) Protoporphyrin IX is used as a negative control for Zn (II) Protoporphyrin (an inihibitor of heme oxygenase). Heme oxygenase has been implicated in tumor cell resistance to chemotherapy, reduction of free radical formation and inflammation, and associated with vascular repair .

HY-150260

SA09-Cu	Bacterial	Infection
SA09-Cu is a noncompetitive and potent NDM-1 inhibitor with an IC₅₀ of 9.6 nM. SA09-Cu can convert NDM-1 into an inactive state by oxidizing the Zn(II)-thiolate site of the enzyme and avoids to be reduced by intracellular thiols of bacteria. SA09-Cu exhibits excellent inhibition against a series of clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) in restoring the Meropenem (HY-13678) effect, and slows down the development of carbapenem resistance .

HY-162050

8AQ−Cu−5Iu	Sirtuin	Neurological Disease
8AQ?Cu?5Iu is an activator of SIRT1. 8AQ?Cu?5Iu exhibits neuroprotective effects by modulating the SIRT1/3-FOXO3a signaling pathway. 8AQ?Cu?5Iu can used in study attenuating neurodegenerative diseases .

HY-121638A

(5Z,2E)-CU-3 1 Publications Verification	Apoptosis DGK	Cancer
(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC₅₀ value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a K_m value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells .

HY-P0063

Copper tripeptide 1 Publications Verification GHK-Cu
Copper tripeptide (GHK-Cu) is a tripeptide. During wound healing, copper tripeptide may be freed from existing extracellular proteins via proteolysis and serves as a chemoattractant for inflammatory and endothelial cells. Copper tripeptide has been shown to increase messenger RNA production for collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts. Copper tripeptide is a natural modulator of multiple cllular pathways in skin regeneration .

HY-160607

MMA-NODAGA	Others	Others
MMA-NODAGA is a chelator for site-specific labeling of targeting proteins containing unpaired cysteine. MMA-NODAGA can be used to conjugate with exosome and ⁶⁴Cu in image with positron emission tomography (PET) ^<[2].

HY-D1549

o-Pah	Fluorescent Dye	Others
o-Pah is a BODIPY derivative with an -NH₂ and -OH substituted meso-Ph group. o-Pah exhibits metal-induced J-aggregation in the presence of Cu ²⁺ and a specific fluorescence enhancement for Hg ²⁺ (Ex/Em=483/(495-600) nM) .

HY-D1601

N-Aminofluorescein	Fluorescent Dye	Others
N-Aminofluorescein is a fluorescein hydrazide with spiro form, a highly selective and sensitive fluorescence probe for Cu ²⁺. N-Aminofluorescein has no selective fluorescence response to other common metal ions, can be used for direct detection of Cu ²⁺ in biological systems with λex/em=495/516 nm .

HY-156780

NSC 689534 1 Publications Verification	Cuproptosis Others	Cancer
NSC 689534 can form copper chelate with Cu ²⁺. NSC 689534/Cu ²⁺ complex is a potent oxidative stress inducer, and has antitumor activity .

HY-132927B

Salpyran dihydrochloride	Reactive Oxygen Species	Inflammation/Immunology
Salpyran dihydrochloride is a Cu(II) selective chelator with therapeutic potential. Salpyran dihydrochloride prevents the formation of reactive oxygen species from the binary Cu(II)/H₂O₂ system .

HY-132927

Salpyran

Others Others

Salpyran is a Cu(II) selective chelator with therapeutic potential.
HY-132927A

Salpyran hydrochloride

Others Others

Salpyran is a Cu(II) selective chelator with therapeutic potential .
HY-100486

BTTAA

2 Publications Verification

Others Others

BTTAA is a Cu(I)-stabilizing ligand, whch performs potently with ubiquitin Glu18AzF.

Salpyran	Others	Others
Salpyran is a Cu(II) selective chelator with therapeutic potential.

Salpyran hydrochloride	Others	Others
Salpyran is a Cu(II) selective chelator with therapeutic potential .

BTTAA 2 Publications Verification	Others	Others
BTTAA is a Cu(I)-stabilizing ligand, whch performs potently with ubiquitin Glu18AzF.

HY-144324

AChE-IN-6	Cholinesterase (ChE)	Neurological Disease
AChE-IN-6 (Compound 12a) is an optimal multifunctional ligand with significant inhibition of AChE (EeAChE, IC₅₀ = 0.20 μM; HuAChE, IC₅₀ = 37.02 nM) and anti-Aβ activity (IC₅₀ = 1.92 μM for self-induced Aβ1-42 aggregation; IC₅₀ = 1.80 μM for disaggregation of Aβ1-42 fibrils; IC₅₀ = 2.18 μM for Cu2+-induced Aβ1-42 aggregation; IC₅₀ = 1.17 μM for disaggregation of Cu2+-induced Aβ1-42 fibrils). AChE-IN-6 has the potential for the research of Alzheimer's disease .

HY-D1550

10-(4-(Bis(2-acetoxyethyl)amino)phenyl)-BODIPY 505/515

Fluorescent Dye Others

10-(4-(Bis(2-acetoxyethyl)amino)phenyl)-BODIPY 505/515 is a fluorescent dye for Cu ²⁺ ion .
HY-153419

BTTES

Others Others

BTTES is a tris(triazolylmethyl)amine-based ligand for Cu(I) without apparent toxicity. BTTES IMPROVES the cycloaddition reaction rapidly in living systems .

10-(4-(Bis(2-acetoxyethyl)amino)phenyl)-BODIPY 505/515	Fluorescent Dye	Others
10-(4-(Bis(2-acetoxyethyl)amino)phenyl)-BODIPY 505/515 is a fluorescent dye for Cu ²⁺ ion .

BTTES	Others	Others
BTTES is a tris(triazolylmethyl)amine-based ligand for Cu(I) without apparent toxicity. BTTES IMPROVES the cycloaddition reaction rapidly in living systems .

HY-141511

Coppersensor 1 1 Publications Verification	Fluorescent Dye	Neurological Disease Cancer
Coppersensor-1 (CS1) is a membrane-permeable fluorescent dye. Coppersensor-1 has a picomolar affinity for Cu ⁺ with high selectivity over competing cellular metalions. Coppersensor-1 as a probe, can selective and sensitive detection of copper(I) ions (Cu ⁺) in biological samples, including live cells. Coppersensor-1 can be used for the research of imaging of severe diseases such as cancer, cardiovascular disorders and neurogenerative diseases .

HY-D2288

CalFluor 580 azide	Fluorescent Dye	Others
CalFluor 580 azide is a fluorogenic azide probe that is activated by Cu-catalyzed or metal-free click reaction. CalFluor 580 azide is not fluorescent until it is reacted with alkynes .

HY-D2289

CalFluor 647 azide	Fluorescent Dye	Others
CalFluor 647 azide is a fluorogenic azide probe that is activated by Cu-catalyzed or metal-free click reaction. CalFluor 647 azide is not fluorescent until it is reacted with alkynes .

HY-161181

BTTES-acid	Others	Others
BTTES-acid is an analog of BTTES. BTTES is a tris(triazolylmethyl)amine-based ligand for Cu(I) without apparent toxicity. BTTES improves the cycloaddition reaction rapidly in living systems .

HY-N7697E

Chitotriose trihydrochloride	Others	Others
Chitotriose trihydrochloride is an orally active chitooligosaccharide with antioxidant activities. Chitotriose trihydrochloride inhibits hydroxylation of benzoate to salicylate by H₂O₂ in the presence of Cu ²⁺ (IC₅₀ value of 80 μM) .

HY-151686

Bz-(Me)Tz-NHS	ADC Linker	Others
Bz-(Me)Tz-NHS is a click chemistry reagent containing an methyltetrazine group. Bz-(Me)Tz-NHS is 3rd generation Click-Linker for Cu-free click conjugation .

HY-D0023

Pyranine 1 Publications Verification HPTS; Solvent Green 7	Fluorescent Dye	Others
Pyranine (HPTS; Solvent Green 7) is a pH-sensitive fluorescent indicator. Pyranine acts as a class of fluorescent chemosensor for the Cu ⁺ ion(λex=450 nm, λem=510 nm) .

HY-147104

Fmoc-Lys(5-FITC)-OH	Fluorescent Dye	Others
Fmoc-Lys(5-FITC)-OH is a marker for polypeptides or proteins. FITC is a fluorescence probe for the labeling of amines. FITC is a pH- and Cu ²⁺-sensitive fluorescence dye .

HY-151708

CalFluor 488 Azide	Fluorescent Dye	Others
CalFluor 488 Azide is a water-soluble fluorogenic azide probe. CalFluor 488 Azide is activated by Cu-catalyzed or metal-free click reaction. CalFluor 488 Azide is not fluorescent until it is reacted with alkynes .

HY-128757

Remibrutinib 3 Publications Verification LOU064	Btk	Inflammation/Immunology
Remibrutinib, is a potent and orally active bruton tyrosine kinase (BTK) inhibitor with an IC₅₀ value of 1 nM. Remibrutinib inhibits BTK activity with an IC₅₀ value of 0.023 μM in blood . Remibrutinib has the potential for Chronic urticaria (CU) treatment .

HY-16074

ATN-224 3 Publications Verification Bis(choline)tetrathiomolybdate	SOD	Cancer
ATN-224 is an oral Cu ²⁺/Zn ²⁺-superoxide dismutase 1 (SOD1) inhibitor. ATN-224 inhibits SOD1 activity in endothelial cells, an effect that is dose dependent with an IC₅₀ of 17.5±3.7 nM.

HY-157917

Nitro-PAPS disodium dihydrate	Biochemical Assay Reagents	Others
Nitro-PAPS disodium dihydrate is a highly sensitive colometric reagent for Fe(II) detection with a maximal absorption wavelength of 592 nm. Nitro-PAPS disodium dihydrate is suitable for the determination of Fe(II) in serum and also be used to determine micro molar levels of Cu, Zn, Ni, Co and V .

HY-144392

AChE/BuChE-IN-1	Cholinesterase (ChE)	Neurological Disease
AChE/BuChE-IN-1 (Compound 1), a chrysin derivative, is a selective butyrylcholinesterase (BuChE) inhibitor with an IC₅₀ of 0.48 μM. AChE/BuChE-IN-1 inhibits acetylcholinesterase (AChE) with an IC₅₀ of 7.16 μM. AChE/BuChE-IN-1 shows strong scavenging ·OH activities with a IC₅₀ of 0.1674 μM. AChE/BuChE-IN-1 inhibits reactive oxygen species (ROS), Aβ_1-42 aggregation (self-, Cu₂₊-induced, AChE-induced). AChE/BuChE-IN-1 has high BBB permeability and bioavailability and low cell toxicity. AChE/BuChE-IN-1 has the potential for Alzheimer' disease (AD) research .

HY-151705

Alkyne Cholesterol	Liposome	Metabolic Disease
Alkyne Cholesterol, a modified lipid, is a click chemistry reagent containing an alkyne group. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents in the presence of a copper (Cu)-containing catalyst. Alkyne Cholesterol can be used for tracking cellular cholesterol metabolism and localization .

HY-151691

Trisulfo-Cy3 Methyltetrazine	ADC Linker	Others
Trisulfo-Cy3 Methyltetrazine is a click chemistry reagent containing an methyltetrazine group. Methyltetrazine-activated Cy3 probe reacts with TCO-containing compounds via an Inverse-Electron-Demand Diels-Alder reaction to form a stable covalent bond and does not require Cu-catalyst or elevated temperatures .

HY-N7135

Tropolone	Tyrosinase	Others
Tropolone is a Tropone derivative with a hydroxyl group at the 2-position, and is the precursor of many Azulene derivatives, such as 2-methylazulene-1-carboxylate. Tropolone is a potent mushroom tyrosinase inhibitor with an IC₅₀ of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU ²⁺ Reversal .

HY-W250928C

Biotin-PEG-azide (MW 2000) Carbamic acid, N-(17-azido-3,6,9,12,15-pentaoxaheptadec-1-yl)-, 1,1-dimethylethyl ester	Fluorescent Dye	Others
Biotin-PEG-azide (MW 2000) is a biotin labeled PEG derivative. Biotin is an enzyme co-factor, can be used for labeling protein; PEG is a hydrophilic and water-soluble polymer with low toxicity; azide, is a moderately good leaving group, can react with alkyne by Cu-catalyzation, which improve the efficiency of biotin binding targets.

HY-W250928D

Biotin-PEG-azide (MW 3400) Carbamic acid, N-(17-azido-3,6,9,12,15-pentaoxaheptadec-1-yl)-, 1,1-dimethylethyl ester	Fluorescent Dye	Others
Biotin-PEG-azide (MW 3400) is a biotin labeled PEG derivative. Biotin is an enzyme co-factor, can be used for labeling protein; PEG is a hydrophilic and water-soluble polymer with low toxicity; azide, is a moderately good leaving group, can react with alkyne by Cu-catalyzation, which improve the efficiency of biotin binding targets.

HY-152506

Antioxidant agent-8	Amyloid-β	Neurological Disease
Antioxidant agent-8 is an orally active inhibitor of Aβ_1-42 deposition. Antioxidant agent-8 inhibits fibril aggregation (IC₅₀=11.15 µM) and promotes fibril disaggregation (IC₅₀=6.87 µM). Antioxidant agent-8 also inhibits Cu ²⁺-induced Aβ_1-42 fibril aggregation (IC₅₀=3.69 µM) and promotes Cu ²⁺-induced Aβ_1-42 fibril disaggregation (IC₅₀=3.35 µM). Antioxidant agent-8 has antioxidant activity, anti-inflammatory activity, biosafety, blood-brain barrier permeability and neuroprotective effect .

Cat. No.	Product Name	Type

HY-D1601

N-Aminofluorescein	Fluorescent Dyes/Probes
N-Aminofluorescein is a fluorescein hydrazide with spiro form, a highly selective and sensitive fluorescence probe for Cu ²⁺. N-Aminofluorescein has no selective fluorescence response to other common metal ions, can be used for direct detection of Cu ²⁺ in biological systems with λex/em=495/516 nm .

HY-141511

Coppersensor 1

1 Publications Verification

Fluorescent Dyes/Probes

Coppersensor-1 (CS1) is a membrane-permeable fluorescent dye. Coppersensor-1 has a picomolar affinity for Cu ⁺ with high selectivity over competing cellular metalions. Coppersensor-1 as a probe, can selective and sensitive detection of copper(I) ions (Cu ⁺) in biological samples, including live cells. Coppersensor-1 can be used for the research of imaging of severe diseases such as cancer, cardiovascular disorders and neurogenerative diseases .

HY-D1549

o-Pah	Dyes
o-Pah is a BODIPY derivative with an -NH₂ and -OH substituted meso-Ph group. o-Pah exhibits metal-induced J-aggregation in the presence of Cu ²⁺ and a specific fluorescence enhancement for Hg ²⁺ (Ex/Em=483/(495-600) nM) .

HY-D1550

10-(4-(Bis(2-acetoxyethyl)amino)phenyl)-BODIPY 505/515

Fluorescent Dyes/Probes

10-(4-(Bis(2-acetoxyethyl)amino)phenyl)-BODIPY 505/515 is a fluorescent dye for Cu ²⁺ ion .

HY-D2288

CalFluor 580 azide	Fluorescent Dyes/Probes
CalFluor 580 azide is a fluorogenic azide probe that is activated by Cu-catalyzed or metal-free click reaction. CalFluor 580 azide is not fluorescent until it is reacted with alkynes .

HY-D2289

CalFluor 647 azide	Fluorescent Dyes/Probes
CalFluor 647 azide is a fluorogenic azide probe that is activated by Cu-catalyzed or metal-free click reaction. CalFluor 647 azide is not fluorescent until it is reacted with alkynes .

HY-D0023

Pyranine 1 Publications Verification HPTS; Solvent Green 7	Fluorescent Dyes/Probes
Pyranine (HPTS; Solvent Green 7) is a pH-sensitive fluorescent indicator. Pyranine acts as a class of fluorescent chemosensor for the Cu ⁺ ion(λex=450 nm, λem=510 nm) .

HY-151708

CalFluor 488 Azide	Fluorescent Dyes/Probes
CalFluor 488 Azide is a water-soluble fluorogenic azide probe. CalFluor 488 Azide is activated by Cu-catalyzed or metal-free click reaction. CalFluor 488 Azide is not fluorescent until it is reacted with alkynes .

HY-150086

Copper Fluor-4 CF4	Dyes
Copper Fluor-4 (CF4) is a Cu ⁺-specific fluorescent probe based on a rhodol dye scaffold. Copper Fluor-4 has high copper selectivity, particularly over zinc and iron, as well as abundant cellular alkali and alkaline earth metals. Copper Fluor-4 is stable in a physiologically relevant pH regime between 6 and 8 (Ex: 488 nm) .

Cat. No.	Product Name	Type

HY-151705

Alkyne Cholesterol	Drug Delivery
Alkyne Cholesterol, a modified lipid, is a click chemistry reagent containing an alkyne group. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents in the presence of a copper (Cu)-containing catalyst. Alkyne Cholesterol can be used for tracking cellular cholesterol metabolism and localization .

HY-W011060

Cryptand 2.2.2 4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane	Biochemical Assay Reagents
Cryptand 2.2.2 is a metal ion chelator that can be used as a reducing agent and stabilizer to prepare nanoparticles. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn ²⁺, Co ²⁺, Ni ²⁺, Cu ²⁺) .

HY-W582564

Cu(Ⅱ)-EDTA disodium tetrahydrate Ethylenediaminetetraacetic acid copper disodium tetrahydrate	Chelators
Cu(Ⅱ)-EDTA disodium tetrahydrate, a typical contaminant in industrial wastewater, is an EDTA-complexed heavy metal. Cu(Ⅱ)-EDTA disodium tetrahydrate can be used in research on the recovery of heavy metal resources from mixed wastewater .

HY-157917

Nitro-PAPS disodium dihydrate	Chelators
Nitro-PAPS disodium dihydrate is a highly sensitive colometric reagent for Fe(II) detection with a maximal absorption wavelength of 592 nm. Nitro-PAPS disodium dihydrate is suitable for the determination of Fe(II) in serum and also be used to determine micro molar levels of Cu, Zn, Ni, Co and V .

Cat. No.	Product Name	Target	Research Area

HY-P5018

NOTA-AE105	Peptides	Cancer
NOTA-AE105 is an PET ligand of urokinase-type plasminogen activator receptor (uPAR), which can be radiolabeled by ⁶⁴Cu and ⁶⁸Ga. ⁶⁸Ga-NOTA-AE105 and ⁶⁴Cu-NOTA-AE105 shows high image contrast, resulting in clear tumor delineation .

HY-P5243

Copper tripeptide-3 AHK-Cu	Peptides	Others
Copper tripeptide-3 (AHK-Cu) is a bioactive peptide with promotion of hair growth effect and has been reported used as a cosmetic ingredient .

HY-P5079

LGLLLRHLRHHSNLLANI	Peptides	Others
LGLLLRHLRHHSNLLANI (B18) is an 18 amino acid peptide. LGLLLRHLRHHSNLLANI derives from the membrane-associated protein binding. LGLLLRHLRHHSNLLANI shows a high affinity for Cu(2+) ions .

HY-P4666

Valylhistidine	Peptides	Others
Valylhistidine is a dipeptide consisting of valine and histidine (Val-His). Valylhistidine forms a dipeptide complex with Cu(II) that mimics superoxide dismutase, but lacks activity .

HY-P4283

Glycylhistidylglycine	Peptides	Others
Glycylhistidylglycine is composed of two glycines and one histidine, which can detect and remove the concentration of Cu2+ ions in wastewater by forming a tripeptide complex with copper and nickel ions.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7135

Tropolone	Olax imbricata Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Olacaceae Other Diseases Plants Disease Research Fields	Tyrosinase
Tropolone is a Tropone derivative with a hydroxyl group at the 2-position, and is the precursor of many Azulene derivatives, such as 2-methylazulene-1-carboxylate. Tropolone is a potent mushroom tyrosinase inhibitor with an IC₅₀ of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU ²⁺ Reversal .

HY-N2362

DL-Alanine DL-2-Aminopropionic acid	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
DL-alanine, an orally active amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver .

HY-N7697E

Chitotriose trihydrochloride	Polysaccharides Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields Saccharides	Others
Chitotriose trihydrochloride is an orally active chitooligosaccharide with antioxidant activities. Chitotriose trihydrochloride inhibits hydroxylation of benzoate to salicylate by H₂O₂ in the presence of Cu ²⁺ (IC₅₀ value of 80 μM) .

Species:	Human (1) Virus (1)
Tag:	His (2)
Source:	HEK293 (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71048

	SOD1 Protein, Human (His) Superoxide Dismutase [Cu-Zn]; Superoxide Dismutase 1; hSod1; SOD1	Human	E. coli
	SOD1 Protein, an enzyme crucial for cellular defense, operates as a superoxide dismutase, neutralizing radicals to safeguard cells from oxidative stress. Its enzymatic activity underscores the importance of SOD1 in maintaining cellular homeostasis and protecting biological systems from the harmful effects of reactive oxygen species accumulation. SOD1 Protein, Human (His) is the recombinant human-derived SOD1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of SOD1 Protein, Human (His) is 154 a.a., with molecular weight of ~20.0 kDa.

HY-P75097

	HA/Hemagglutinin Protein, H3N2 (AGG53108, HEK293, His) Influenza A H3N2 (A/swine/Thailand/Cu-P53/2012) Hemagglutinin / HA Protein (HEK293, His)	Virus	HEK293
	The hemagglutinin (HA) protein attaches viral particles to host cells by binding to sialic acid-containing receptors and induces viral particle internalization through clathrin-dependent endocytosis. HA also promotes an alternative clathrin- and caveolin-independent pathway for some virions. HA/Hemagglutinin Protein, H3N2 (AGG53108, HEK293, His) is the recombinant Virus-derived HA/Hemagglutinin protein, expressed by HEK293 , with C-His labeled tag. The total length of HA/Hemagglutinin Protein, H3N2 (AGG53108, HEK293, His) is 525 a.a., with molecular weight of ~57.9 kDa.

Cat. No.	Product Name	Chemical Structure

HY-N2362S2

DL-Alanine-d3

DL-Alanine-d₃ is the deuterium labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver[1][2][3][4][5][6].

HY-N2362S

DL-Alanine-13C-1

DL-Alanine- ¹³C-1 is the ¹³C-labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver[1][2][3][4][5][6].

HY-N2362S1

DL-Alanine-13C-3

DL-Alanine- ¹³C-3 is the ¹³C-labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver[1][2][3][4][5][6].

HY-N2362S5

DL-Alanine-15N

DL-Alanine- ¹⁵N is the ¹⁵N labeled DL-Alanine[1]. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver[2][3][4][5][6][7].

Cat. No.	Product Name	Application	Reactivity

HY-P81228

SOD1 Antibody Superoxide Dismutase 1; ALS 1; ALS; ALS1; Amyotrophic lateral sclerosis 1 adult; Amyotrophic lateral sclerosis 1; Cu/Zn SOD; Cu/Zn superoxide dismutase; Homodimer; Indophenoloxidase A; IPOA; Mn superoxide dismutase; SOD 1; SOD; SOD soluble; SOD2; SODC; Soluble indophenoloxidase A; Superoxide dismutase 1; Superoxide dismutase 1 soluble; Superoxide dismutase Cu Zn; Superoxide dismutase cystolic; SODC_HUMAN; Superoxide dismutase [Cu-Zn]; hSod1; Ipo1; SODC; Ipo-1; Sod-1; CuZnSOD; Cu/Zn-SOD; MGC107553; B430204E11Rik; superoxide-dimuta se-1.	WB, IHC-P, IHC-F, ICC, IF, Flow-Cyt, ELISA	Human, Mouse, Rat(predicted: Pig, Cow, Horse)
SOD1 Antibody is an unconjugated, approximately 17 kDa, rabbit-derived, anti-SOD1 polyclonal antibody. SOD1 Antibody can be used for: 0 expriments in human, mouse, rat, and predicted: pig, cow, horse background without labeling.

HY-P81166

ox-LDL Antibody ox-LDL: LDL (Copper oxidized); Cu2SO4 oxidized low density lipoprotein; oxidized low density lipoprotein; Low density lipoprotein; MDA oxidized LDL; MDA oxidized low density lipoprotein. 氧化型低密度脂蛋白；	ELISA; IHC-P; IHC-F; Flow-Cyt; IF	Human,
ox-LDL Antibody is an unconjugated, approximately 31 kDa, rabbit-derived, anti-ox-LDL polyclonal antibody. ox-LDL Antibody can be used for: ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, background without labeling.

HY-P82675

Superoxide Dismutase 3 Antibody (YA2420) EC SOD; Extracellular superoxide dismutase [Cu Zn]; Extracellular superoxide dismutase preCursor; SOD3; Superoxide dismutase 3 extracellular	WB, IHC-P	Human

Cat. No.	Product Name		Classification

HY-151686

Bz-(Me)Tz-NHS

Tetrazine

Bz-(Me)Tz-NHS is a click chemistry reagent containing an methyltetrazine group. Bz-(Me)Tz-NHS is 3rd generation Click-Linker for Cu-free click conjugation .

HY-151705

Alkyne Cholesterol		Labeling and Fluorescence Imaging Alkynes
Alkyne Cholesterol, a modified lipid, is a click chemistry reagent containing an alkyne group. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents in the presence of a copper (Cu)-containing catalyst. Alkyne Cholesterol can be used for tracking cellular cholesterol metabolism and localization .

HY-D2288

CalFluor 580 azide		Azide
CalFluor 580 azide is a fluorogenic azide probe that is activated by Cu-catalyzed or metal-free click reaction. CalFluor 580 azide is not fluorescent until it is reacted with alkynes .

HY-D2289

CalFluor 647 azide		Azide
CalFluor 647 azide is a fluorogenic azide probe that is activated by Cu-catalyzed or metal-free click reaction. CalFluor 647 azide is not fluorescent until it is reacted with alkynes .

HY-151708

CalFluor 488 Azide		Azide
CalFluor 488 Azide is a water-soluble fluorogenic azide probe. CalFluor 488 Azide is activated by Cu-catalyzed or metal-free click reaction. CalFluor 488 Azide is not fluorescent until it is reacted with alkynes .

HY-151691

Trisulfo-Cy3 Methyltetrazine		Tetrazine
Trisulfo-Cy3 Methyltetrazine is a click chemistry reagent containing an methyltetrazine group. Methyltetrazine-activated Cy3 probe reacts with TCO-containing compounds via an Inverse-Electron-Demand Diels-Alder reaction to form a stable covalent bond and does not require Cu-catalyst or elevated temperatures .

HY-151687

Fmoc-L-Tyr(2-azidoethyl)-OH		Azide
Fmoc-L-Tyr(2-azidoethyl)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Tyr(2-azidoethyl)-OH is unnatural Fmoc-protected Tyrosine derivative bears an azidoethyl substitution as reactive handle e.g. for biorthogonal conjugations, via a Cu(I)-catalyzed 1,3-dipolar Click cycloaddition with alkynes. And azido-UAAs can be employed as IR reporters .

HY-151833

Methyltetrazine-amido-N-bis(PEG4-acid)		Tetrazine
Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent containing an azide group. Methyltetrazine-amido-N-bis(PEG4-acid) is a PEG derivative that contains a methyltetrazine group and two acid groups. This reagent can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. PEG linker increases the water solubility of the compound. Reagent grade, for research use only . Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.


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Cu

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Cu

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Natural
Products