2. Search Result
Search Result
Results for "

Cys481

" in MedChemExpress (MCE) Product Catalog:

36

Inhibitors & Agonists

40

Peptides

1

Natural
Products

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-17600
    Acalabrutinib
    Maximum Cited Publications
    20 Publications Verification

    ACP-196

    		 Btk Cancer
    Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL) . Acalabrutinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Acalabrutinib
  • HY-131705
    BTK inhibitor 17

    		Btk Inflammation/Immunology
    BTK inhibitor 17 is a potent and orally active irreversible BTK inhibitor with an IC50 of 2.1 nM. BTK inhibitor 17 can be used for rheumatoid arthritis research .
    BTK inhibitor 17
  • HY-W757743
    Acalabrutinib-d3

    ACP-196-d3

    		 Isotope-Labeled Compounds Others
    Acalabrutinib-d3 (ACP-196-d3) is the deuterated form of Acalabrutinib (HY-17600). Acalabrutinib (ACP-196) is an orally active, irreversible, highly selective second-generation BTK inhibitor. Acalabrutinib covalently binds to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib shows strong targeting and efficacy in mouse models of chronic lymphocytic leukemia (CLL).
    Acalabrutinib-d3
  • HY-12554
    Terlipressin

    		Vasopressin Receptor Cardiovascular Disease Inflammation/Immunology Endocrinology
    Terlipressin is a vasopressin analogue with potent vasoactive properties. Terlipressin is a highly selective vasopressin V1 receptor agonist that reduces the splanchnic blood flow and portal pressure and controls acute variceal bleeding. Terlipressin exerts anti-inflammatory and anti-oxidative effects. Terlipressin has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research .
    Terlipressin
  • HY-P1766
    Adrenomedullin (11-50), rat

    		CGRP Receptor Cardiovascular Disease
    Adrenomedullin (11-50), rat is the C-terminal fragment (11-50) of rat adrenomedullin. Rat adrenomedullin induces a selective arterial vasodilation via CGRP1 receptors .
    Adrenomedullin (11-50), rat
  • HY-12554A
    Terlipressin diacetate
    1 Publications Verification

    		 Vasopressin Receptor Cardiovascular Disease Inflammation/Immunology Endocrinology
    Terlipressin diacetate is a vasopressin analogue with potent vasoactive properties. Terlipressin diacetate is a highly selective vasopressin V1 receptor agonist that reduces the splanchnic blood flow and portal pressure and controls acute variceal bleeding. Terlipressin diacetate exerts anti-inflammatory and anti-oxidative effects. Terlipressin diacetate has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research .
    Terlipressin diacetate
  • HY-P3099
    Uroguanylin (human)

    		Guanylate Cyclase Cancer
    Uroguanylin (human) is a natural ligand for the Guanylyl Cyclase (GCC) receptor expressed in metastatic colorectal cancer tumors. Uroguanylin (human) has anti-tumor actions in an animal model for human colon cancer .
    Uroguanylin (human)
  • HY-12554B
    Terlipressin acetate

    		Vasopressin Receptor Cardiovascular Disease Inflammation/Immunology Endocrinology
    Terlipressin acetate is a vasopressin analogue with potent vasoactive properties. Terlipressin acetate is a highly selective vasopressin V1 receptor agonist that reduces the splanchnic blood flow and portal pressure and controls acute variceal bleeding. Terlipressin acetate exerts anti-inflammatory and anti-oxidative effects. Terlipressin acetate has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research .
    Terlipressin acetate
  • HY-108741A
    Plecanatide acetate

    		Guanylate Cyclase Inflammation/Immunology
    Plecanatide acetate, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide acetate activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide acetate can be used for the research of chronic idiopathic constipation, and it also shows anti-inflammatory activity in models of murine colitis .
    Plecanatide acetate
  • HY-108741
    Plecanatide

    		Guanylate Cyclase Inflammation/Immunology
    Plecanatide, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis .
    Plecanatide
  • HY-P3732
    RGD-4C

    		Integrin Cancer
    RGD-4C is a arginine-glycine-aspartic acid peptide (ACDCRGDCFC) with integrin binding activity. The Arg-Gly-Asp (RGD) sequence serves as the primary integrin recognition site in extracellular matrix proteins, and peptides containing this sequence can mimic the recognition specificity of the matrix proteins. RGD-4C is a αv-integrin ligand, can conjugate with bioactive molecule to exert antitumor effects in animal models .
    RGD-4C
  • HY-P5839
    α-Conotoxin MrIC

    		nAChR Neurological Disease
    α-Conotoxin MrIC is an α7nAChR biased agonist. α-Conotoxin MrIC exclusively activates α7nAChR regulated by type II positive allosteric modulators, including PNU120596. α-Conotoxin MrIC can be used to study neurological diseases and also to probe the pharmacological properties of α7nAChR .
    α-Conotoxin MrIC
  • HY-P5077
    Guanylin (mouse, rat)

    		Guanylate Cyclase Metabolic Disease
    Guanylin (mouse, rat), a petide, is composed of 15 amino acids. Guanylin (mouse, rat) is an activator of intestinal guanylate cyclase. Guanylin (mouse, rat) can be used for the research of diarrhea .
    Guanylin (mouse, rat)
  • HY-P2949
    Pandinotoxin Kα

    		Potassium Channel Cancer
    Pandinotoxin Kα, isolated from the venom of Pandinus imperator, is the inhibitor of A-type potassium channel .
    Pandinotoxin Kα
  • HY-P5816
    BmK-M1

    		Sodium Channel Neurological Disease
    BmK-M1 is a scorpion toxin, and is composed of 64 amino acids cross-linked by four disulfide bridges. BmK-M1 inhibits Na + channel and can be considered both as a cardiotoxin and a neurotoxin .
    BmK-M1
  • HY-P5925
    Ssm spooky toxin

    SsTx Toxin

    		 Potassium Channel Inflammation/Immunology
    Ssm Spooky Toxin from?Scolopendra mutilans, exhibits lethal toxicity in hematological and respiratory systems by potently inhibiting KCNQ (voltage-gated potassium channel family 7) channels, with IC50? of 2.8 μM, 5.26 μM and 0.1-0.3 M for Kv7.4, Kv1.3, and Shal channel, respectivily. Ssm Spooky Toxin inhibits cytokine generation by specifically acting on the KV1.3 channel in T cells. Ssm Spooky Toxin plays an essential role in the centipede’s circulatory system .
    Ssm spooky toxin
  • HY-P4898
    Anthopleurin-A

    		Sodium Channel Cardiovascular Disease
    Anthopleurin-A is a soidum channel toxin. Anthopleurin-A is selective for cardiac channels and has cardiotonic effect. Anthopleurin-A can be isolated from the sea anemone .
    Anthopleurin-A
  • HY-P4898A
    Anthopleurin-A TFA

    		Sodium Channel Cardiovascular Disease
    Anthopleurin-A TFA is a soidum channel toxin. Anthopleurin-A TFA is selective for cardiac channels and has cardiotonic effect. Anthopleurin-A TFA can be isolated from the sea anemone .
    Anthopleurin-A TFA
  • HY-17600S
    Acalabrutinib-d4

    ACP-196-d4

    		 Btk Cancer
    Acalabrutinib-d4 is a deuterium labeled Acalabrutinib. Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor[1]. Acalabrutinib-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Acalabrutinib-d4
  • HY-P5739
    Mram 8

    		Bacterial Infection
    Mram 8 is a cyclotide isolated from Viola philippica, a plant from the Violaceae family .
    Mram 8
  • HY-P5807A
    Cn2 toxin TFA

    β-Mammal toxin Cn2 TFA

    		 Sodium Channel Neurological Disease
    Cn2 toxin TFA (β-Mammal toxin Cn2 TFA) is a single-chain β-scorpion neurotoxic peptide that is the main toxin in scorpion venom. Cn2 toxin (TFA) specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6 .
    Cn2 toxin TFA
  • HY-P1266
    α-Conotoxin EI

    		nAChR Neurological Disease
    α-Conotoxin EI is a selective nicotinic acetylcholine α1β1γδ receptor (nAChR) antagonist (IC50=187 nM) and an α3β4 receptor inhibitor. α-Conotoxin EI can block muscle and ganglionic receptors .
    α-Conotoxin EI
  • HY-P1219
    Jingzhaotoxin-III

    β-TRTX-Cj1α

    		 Sodium Channel Neurological Disease
    Jingzhaotoxin-III is a potent and selective blocker of Nav1.5 channels, with an IC50 of 348 nM, and shows no effect on other sodium channel isoforms. Jingzhaotoxin-III can selectively inhibit the activation of cardiac sodium channel but not neuronal subtypes, and hopefully represents an important ligand for discriminating cardiac VGSC subtype .
    Jingzhaotoxin-III
  • HY-P1604
    ATX-II

    		Sodium Channel Inflammation/Immunology
    ATX-II is a specific Na + channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II causes delayed inactivation of the Na +
    ATX-II
  • HY-P5681
    Human α-Defensin 6

    		Bacterial Infection Inflammation/Immunology
    Human α-Defensin 6, a 32-residue cysteine-rich peptide, can inhibit bacterial invasion and contribute to the mucosal immunity. Human α-Defensin 6 forms ordered self-assembly fibrils and nanonets that surround and entangle bacteria after stochastic binding to bacterial surface proteins. Human α-Defensin 6 also inhibits C. albicans biofilm formation .
    Human α-Defensin 6
  • HY-P1604A
    ATX-II TFA

    		Sodium Channel Inflammation/Immunology
    ATX-II TFA is a specific Na + channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II TFA causes delayed inactivation of the Na +
    ATX-II TFA
  • HY-P5858
    µ-Conotoxin SIIIA

    		Sodium Channel Neurological Disease
    μ-Conotoxin SIIIA is a tetrodotoxin (TTX)-resistant sodium channel blocker. μ-Conotoxin SIIIA is a toxic peptide that can be obtained from the venom of Conus snails. μ-Conotoxin SIIIA can be used in the study of neurological diseases, such as neuropathic pain .
    µ-Conotoxin SIIIA
  • HY-P5626
    Seabream hepcidin

    		Bacterial Infection
    Seabream hepcidin is an antimicrobial peptide with anti-bacterial (V.anguillarum), fungal (S.cerevisiae) and viral hemorrhagic septicemia virus activity .
    Seabream hepcidin
  • HY-P5783
    δ-Buthitoxin-Hj2a

    		Sodium Channel Neurological Disease
    δ-Buthitoxin-Hj2a, a scorpion-venom peptide, is a potent NaV1.1 agonist with an EC50 of 32 nM. δ-Buthitoxin-Hj2a can be used for the Dravet syndrome (DS) research .
    δ-Buthitoxin-Hj2a
  • HY-P3499
    Dolcanatide

    		Guanylate Cyclase Inflammation/Immunology
    Dolcanatide is an orally active GC-C (guanylate cyclase-C) agonist. Dolcanatide shows laxative, anti-nociceptive and anti-inflammatory activity. Dolcanatide can be used in inflammatory bowel disease research .
    Dolcanatide
  • HY-P1952
    µ-Conotoxin-CnIIIC

    		Sodium Channel Inflammation/Immunology
    μ-Conotoxin-CnIIIC is a 22-residue conopeptide that can be isolated from Conus consors. μ-Conotoxin-CnIIIC is a potent and persistent blocker of NaV1.4 channel. μ-Conotoxin-CnIIIC has analgesic, anaesthetic and myorelaxant properties .
    µ-Conotoxin-CnIIIC
  • HY-P5144
    Aah II

    		Sodium Channel Inflammation/Immunology
    Aah II is a sodium channel modulator. Aah II is a toxin that can be isolated from the venom of scorpion Androctonus australis .
    Aah II
  • HY-P1952A
    µ-Conotoxin-CnIIIC acetate

    		Sodium Channel Neurological Disease
    µ-Conotoxin-CnIIIC acetate, a 22-residue conopeptide, is a potent antagonist of the voltage-gated NaV1.4 sodium channel with an IC50 of 1.3 nM acting at the neuromuscular junction. µ-Conotoxin-CnIIIC acetate has myorelaxant and analgesic effects .
    µ-Conotoxin-CnIIIC acetate
  • HY-106302
    Duramycin

    Moli1901; Lancovutide

    		 Bacterial Infection Inflammation/Immunology
    Duramycin (Moli1901) is a lantibiotic derived from Streptomyces cinnamoneuma. Duramycin also is a antimicrobial peptide. Duramycin can be used for the research of cystic fibrosis (CF) .
    Duramycin
  • HY-P5145
    μ-Conotoxin PIIIA

    		Sodium Channel Inflammation/Immunology
    μ-Conotoxin PIIIA is a sodium channel (NaV 1.4) blocker. μ-Conotoxin PIIIA can be isolated from Conus purpurascens .
    μ-Conotoxin PIIIA
  • HY-P0171
    Motixafortide
    2 Publications Verification

    BKT140 (4-fluorobenzoyl); BL-8040; TF14016

    		 CXCR Endocrinology Cancer
    Motixafortide (BKT140 4-fluorobenzoyl) is a novel CXCR4 antagonist with an IC50 vakue of ～1 nM.
    Motixafortide

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: