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Cytochalasin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (2) Apoptosis (1) Arp2/3 Complex (9) Autophagy (2) Bacterial (1) Bcl-2 Family (1) Caspase (1) Drug Derivative (1) Endogenous Metabolite (2) Exosomes (1) Fluorescent Dye (1) Fungal (3) GLUT (1) HIF/HIF Prolyl-Hydroxylase (1) HIV Protease (2) Microtubule/Tubulin (1) Parasite (2) Reactive Oxygen Species (ROS) (2) Reference Standards (3) YAP (1)
By Research Areas:	Cancer (14) Infection (9) Inflammation/Immunology (1)

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Fluorescent Dye

Peptides

Natural
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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16928

Cytochalasin B 40+ Cited Publications Phomin	Arp2/3 Complex	Cancer
Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of actin filaments, disrupting the formation of actin polymers, with K_d value of 1.4-2.2 nM for F-actin. Cytochalasin B blocks cell migration.

HY-N6682

Cytochalasin D Maximum Cited Publications 91 Publications Verification Zygosporin A; NSC 209835	Exosomes Arp2/3 Complex Antibiotic YAP	Infection Cancer
Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap .

HY-P2031

Phallacidin	Arp2/3 Complex	Others
Phallacidin is a natural bicyclic heptapeptide derived from the poisonous mushroom Amanita phalloides. Phallacidin binds to filamentous actin specifically with high affinity, with a K_d of 20 nM. After binding to F-actin, Phallacidin strongly inhibits its depolymerization, stabilizes microfilament structures, and prevents their disruption by drugs such as cytochalasins. When conjugated with a fluorophore, Phallacidin serves as a specific fluorescent probe for F-actin, which is used to clearly visualize the distribution of actin in the cytoskeleton (e.g., stress fibers, cortical peripheral bands) under fluorescence microscopy .

HY-N6773

Cytochalasin A	HIV Protease Fungal	Infection
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC₅₀=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives .

HY-N6774

Cytochalasin C 1 Publications Verification	Others	Infection
Cytochalasin C is a cell-permeable fungal toxin and induces the formation of nuclear rodlets. Cytochalasin C is 10 times less toxic in mice than is cytochalasin D .

HY-N6772

Cytochalasin E	Autophagy	Cancer
Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation .

HY-N8349

19,20-Epoxycytochalasin D	Parasite Endogenous Metabolite	Infection Cancer
19,20-Epoxycytochalasin D, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin D shows potent in vitro antiplasmodial activity and phytotoxicity .

HY-N15497

Terpestacin	Reactive Oxygen Species (ROS) HIF/HIF Prolyl-Hydroxylase	Cancer
Terpestacin is found in Phoma exigua var. heteromorpha. Terpestacin binds to UQCRB to inhibit the production of mitochondrial ROS and HIF-1α. Terpestacin inhibits tumor angiogenesis in the FM3A breast cancer cell xenograft mouse model. Terpestacin has antitumor activity and phytotoxicity .

HY-129325

Cytochalasin H	Antibiotic Bacterial Apoptosis Bcl-2 Family Caspase	Infection Cancer
Cytochalasin H is a nature product that could be isolated from fungus Phomopsis sp. Cytochalasin H inhibits cell growth and induces apoptosis. Cytochalasin H has anti-angiogenic activity. Cytochalasin H is an antibiotic and has antibacterial activity .

HY-N10290

Cytochalasin K	Others	Others
Cytochalasin K (Compounds 7) is a cytochalasin that inhibits wheat root elongation with an IC₅₀ of 22.58 μM .

HY-N12195

Cytochalasin R	Fungal	Infection
Cytochalasin R (compound 17) is a cytochalasin analogue that can be isolated from the endophytic fungus Phomopsis sp. xz-18. Cytochalasin R shows potential antifungal activity .

HY-16928R

Cytochalasin B (Standard) Phomin (Standard)	Reference Standards Arp2/3 Complex	Cancer
(R)-Duloxetine (Standard) is the analytical standard of (R)-Duloxetine. This product is intended for research and analytical applications. (R)-Duloxetine is a form of Duloxetine (HY-B0161) that causes tonic and usage-dependent impairment of neuronal Na+ channels. (R)-Duloxetine can be used in pain research .

HY-126556

Cytochalasin J	Microtubule/Tubulin	Cancer
Cytochalasin J is a cytochalasin detivative. Cytochalasin J affects mitotic spindel microtubule organization and kinetochore structure, and exhibits cytotoxicity in human leukemia K562 cell with IC₅₀ of 1.5 μM .

HY-N10291

10-Phenyl-[12]-cytochalasins Z16	Others	Others
10-Phenyl-[12]-cytochalasins Z16 (Compounds 5) is a cytochalasin that inhibits wheat root elongation with an IC₅₀ of 17.35 μM .

HY-N14569

Cytochalasin L	Arp2/3 Complex	Cancer
Cytochalasin L has many biological activities, such as inhibiting cytoKinesis reversibly, inhibiting megasophil endocytosis and exocytosis .

HY-N14567

Cytochalasin F	Arp2/3 Complex	Cancer
Cytochalasin F has many biological activities, such as inhibiting cytoKinesis reversibly, inhibiting megasophil endocytosis and exocytosis .

HY-N14568

Cytochalasin G	Arp2/3 Complex	Cancer
Cytochalasin G has many biological activities, such as inhibiting cytoKinesis reversibly, inhibiting megasophil endocytosis and exocytosis .

HY-N14696

Cytochalasin M	Arp2/3 Complex	Cancer
Cytochalasin M has many biological activities, such as inhibiting cytoKinesis reversibly, inhibiting megasophil endocytosis and exocytosis .

HY-N12193

Cytochalasin N	Others	Others
Cytochalasin N is a cytorelaxin derived from endophytic fungus Phomopsis sp.CIB-109 .

HY-N6772R

Cytochalasin E (Standard)	Reference Standards Autophagy	Cancer
Antazoline (phosphate) (Standard) is the analytical standard of Antazoline (phosphate). This product is intended for research and analytical applications. Antazoline phosphate is an H1 receptor antagonist that affects the activity of the central nervous system, has a potent antiarrhythmic effect .

HY-N6773R

Cytochalasin A (Standard)	Reference Standards HIV Protease Fungal	Infection
Ketoprofen (lysinate) (Standard) is the analytical standard of Ketoprofen (lysinate). This product is intended for research and analytical applications. Ketoprofen (RP-19583) lysinate is a non-steroidal anti-inflammatory agent. Ketoprofen lysinate can inhibit the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity .

HY-N8385

19,20-Epoxycytochalasin C	Parasite Endogenous Metabolite	Infection Cancer
19,20-Epoxycytochalasin C, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin C shows potent in vitro antiplasmodial activity and phytotoxicity .

HY-W699318

1-Oleoyl-2-palmitoylglycerol	Reactive Oxygen Species (ROS)	Others
1-Oleoyl-2-palmitoylglycerol is a diacylglycerol in which an oleic acid and a palmitic acid are attached to sn-1 and sn-2 position. 1-Oleoyl-2-palmitoylglycerol enhances the inhibition of superoxide anion production induced by fMLF/cytochalasin B (CB) in human neutrophils. 1-Oleoyl-2-palmitoylglycerol can be used in research about lipid metabolism, membrane fluidity, or the distribution and function of lipids in cells .

HY-182491

Cytochalasin Z2	Others	Others
Cytochalasin Z2 is a 24-oxa-[14]cytochalasan. Cytochalasin Z2 is isolated from wheat cultures of Pyrenophora semeniperda. Cytochalasin Z2 shows no activity in root elongation assays of wheat and tomato seedlings .

HY-N12194

Cytochalasin O	Others	Infection
Cytochalasin O (compound 13) is a secondary metabolite of the phytopathogenic fungus P. sp. CIB-109 .

HY-182487

Deoxaphomin	Arp2/3 Complex	Inflammation/Immunology
Deoxaphomin is a cytochalasin. Deoxaphomin inhibits Actin filament elongation and reduces the viscosity of polymerized actin filaments. Deoxaphomin induces rounding of fibroblasts, contraction of actin cables, formation of actin-containing hairy structures, and formation of actin-containing cytoplasmic rodlets in fibroblasts. Deoxaphomin inhibits membrane ruffling in fibroblasts and capping in lymphocytes .

HY-N17365

2-Hydroxy-2,6-dimethyl-3-benzofuranone	Drug Derivative	Others
2-Hydroxy-2,6-dimethyl-3-benzofuranone (compound 4) is a benzofuranone derivative that can be found in the aerial part of Eupatorium cannabinum subsp. asiaticum .

HY-D3410

CDr17	Fluorescent Dye GLUT	Others
CDr17 is a GLUT1 substrate and selective fluorescent dye staining M1 microphages. CDr17 utilizes the Gating-Oriented Live-cell Distinction (GOLD) mechanism to enter M1 macrophages (Ex/Em = 646/662 nm) .

CDr17	Fluorescent Dye
CDr17 is a GLUT1 substrate and selective fluorescent dye staining M1 microphages. CDr17 utilizes the Gating-Oriented Live-cell Distinction (GOLD) mechanism to enter M1 macrophages (Ex/Em = 646/662 nm) .

Cat. No.	Product Name	Target	Research Area

HY-P2031

Phallacidin	Arp2/3 Complex	Others
Phallacidin is a natural bicyclic heptapeptide derived from the poisonous mushroom Amanita phalloides. Phallacidin binds to filamentous actin specifically with high affinity, with a K_d of 20 nM. After binding to F-actin, Phallacidin strongly inhibits its depolymerization, stabilizes microfilament structures, and prevents their disruption by drugs such as cytochalasins. When conjugated with a fluorophore, Phallacidin serves as a specific fluorescent probe for F-actin, which is used to clearly visualize the distribution of actin in the cytoskeleton (e.g., stress fibers, cortical peripheral bands) under fluorescence microscopy .

Cytochalasin B 40+ Cited Publications Phomin	Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification Cancer	Arp2/3 Complex
Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of actin filaments, disrupting the formation of actin polymers, with K_d value of 1.4-2.2 nM for F-actin. Cytochalasin B blocks cell migration.

Cytochalasin D Maximum Cited Publications 91 Publications Verification Zygosporin A; NSC 209835	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Exosomes Arp2/3 Complex Antibiotic YAP
Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap .

Phallacidin	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Disease Research Fields Source Classification	Arp2/3 Complex
Phallacidin is a natural bicyclic heptapeptide derived from the poisonous mushroom Amanita phalloides. Phallacidin binds to filamentous actin specifically with high affinity, with a K_d of 20 nM. After binding to F-actin, Phallacidin strongly inhibits its depolymerization, stabilizes microfilament structures, and prevents their disruption by drugs such as cytochalasins. When conjugated with a fluorophore, Phallacidin serves as a specific fluorescent probe for F-actin, which is used to clearly visualize the distribution of actin in the cytoskeleton (e.g., stress fibers, cortical peripheral bands) under fluorescence microscopy .

Cytochalasin A	Infection Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Disease Research Fields Source Classification	HIV Protease Fungal
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC₅₀=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives .

Cytochalasin C 1 Publications Verification	Infection Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Disease Research Fields Source Classification	Others
Cytochalasin C is a cell-permeable fungal toxin and induces the formation of nuclear rodlets. Cytochalasin C is 10 times less toxic in mice than is cytochalasin D .

Cytochalasin E	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Disease Research Fields Source Classification Cancer	Autophagy
Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation .

19,20-Epoxycytochalasin D	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Parasite Endogenous Metabolite
19,20-Epoxycytochalasin D, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin D shows potent in vitro antiplasmodial activity and phytotoxicity .

Terpestacin	Animals Terpenoids Sesquiterpenes Source Classification	Reactive Oxygen Species (ROS) HIF/HIF Prolyl-Hydroxylase
Terpestacin is found in Phoma exigua var. heteromorpha. Terpestacin binds to UQCRB to inhibit the production of mitochondrial ROS and HIF-1α. Terpestacin inhibits tumor angiogenesis in the FM3A breast cancer cell xenograft mouse model. Terpestacin has antitumor activity and phytotoxicity .

Cytochalasin H	Antibiotics Gramineae Plants Paspalum scrobiculatum L. Source Classification	Antibiotic Bacterial Apoptosis Bcl-2 Family Caspase
Cytochalasin H is a nature product that could be isolated from fungus Phomopsis sp. Cytochalasin H inhibits cell growth and induces apoptosis. Cytochalasin H has anti-angiogenic activity. Cytochalasin H is an antibiotic and has antibacterial activity .

Cytochalasin K	Alkaloids Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Others
Cytochalasin K (Compounds 7) is a cytochalasin that inhibits wheat root elongation with an IC₅₀ of 22.58 μM .

Cytochalasin R	Structural Classification Alkaloids Microorganisms Pyrrole Alkaloids Source Classification	Fungal
Cytochalasin R (compound 17) is a cytochalasin analogue that can be isolated from the endophytic fungus Phomopsis sp. xz-18. Cytochalasin R shows potential antifungal activity .

Cytochalasin B (Standard) Phomin (Standard)	Structural Classification Natural Products Microorganisms Source Classification	Reference Standards Arp2/3 Complex
(R)-Duloxetine (Standard) is the analytical standard of (R)-Duloxetine. This product is intended for research and analytical applications. (R)-Duloxetine is a form of Duloxetine (HY-B0161) that causes tonic and usage-dependent impairment of neuronal Na+ channels. (R)-Duloxetine can be used in pain research .

Cytochalasin J	Natural Products Microorganisms Source Classification	Microtubule/Tubulin
Cytochalasin J is a cytochalasin detivative. Cytochalasin J affects mitotic spindel microtubule organization and kinetochore structure, and exhibits cytotoxicity in human leukemia K562 cell with IC₅₀ of 1.5 μM .

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Cytochalasin

Inhibitors & Agonists

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