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D3

" in MCE Product Catalog:

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973

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

1370

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas

HY-P2286

D-3
Phosphatase Cancer

D-3, a phosphorpeptide, is an efficient, simple, and specific iPSC-eliminating agent.

*D-3*	Phosphatase	Cancer
D-3, a phosphorpeptide, is an efficient, simple, and specific iPSC-eliminating agent.

HY-124867

D3-βArr	TSH Receptor	Endocrinology
D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 by direct TSHR activation and potentiates TSH-mediated preosteoblast differentiation in vitro.

HY-141412

D-(-)-3-Phosphoglyceric acid disodium 3-Phospho-D-glyceric acid disodium	Enolase	Infection
D-(-)-3-Phosphoglyceric acid (3-Phospho-D-glyceric acid) disodium is an important intermediate in the enzyme-catalysed process of glycolysis. D-(-)-3-Phosphoglyceric acid disodium competitively inhibits yeast enolase.

HY-30219

D-(+)-Phenyllactic acid D-3-Phenyllactic acid	Bacterial Endogenous Metabolite	Infection
D-(+)-Phenyllactic acid is an anti-bacterial agent, excreted by Geotrichum candidum, inhibits a range of Gram-positive from humans and foodstuffs and Gram-negative bacteria found in humans.

HY-18646

23,25-Dihydroxy-24-oxovitamin D3 24-Oxo-23,25-dihydroxyvitamin D3	Endogenous Metabolite	Metabolic Disease
23,25-Dihydroxy-24-oxovitamin D3 is a major metabolite of 24(R),25-Dihydroxyvitamin D3. 23,25-Dihydroxy-24-oxovitamin D3 can be used for the research of metabolic diseases.

HY-15398A

5,6-trans-Vitamin D3 5,6-trans-Cholecalciferol; 5,6-trans-Colecalciferol	VD/VDR	Metabolic Disease
5,6-trans-Vitamin D3 (5,6-trans-Cholecalciferol;5,6-trans-Colecalciferol) is a photoproduct of vitamin D3. Vitamin D3 is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.

HY-32351S

Calcifediol-d3 25-hydroxy Vitamin D3-D3	VD/VDR Endogenous Metabolite	Metabolic Disease
Calcifediol-d3 is a deuterium labeled Calcifediol. Calcifediol, a major circulating metabolite of vitamin D3, is a potent VDR inhibitor.

HY-14286S

Levosimendan D3 Simsndan D3; OR-1259 D3	Potassium Channel Phosphodiesterase (PDE) Autophagy	Cardiovascular Disease
Levosimendan D3 (Simsndan D3) is a deuterium labeled Levosimendan. Levosimendan is a calcium sensitiser used in the management of acutely decompensated congestive heart failure.

HY-B0352S

Mirtazapine D3 Org3770 D3; 6-Azamianserin D3	5-HT Receptor	Neurological Disease
Mirtazapine D3 (Org3770 D3; 6-Azamianserin D3) is a deuterium labeled Mirtazapine. Mirtazapine is a 5-HT receptor inhibitor. Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent by blocking 5-HT2 and 5-HT3 receptors.

HY-115955

Dopamine D3 receptor ligand-3	Dopamine Receptor	Neurological Disease
Dopamine D3 receptor ligand-3 (compound 12C) is a potent D₃ receptor ligand with a K_i of 3.6 nM. Dopamine D3 receptor ligand-3 have high selectivity for D₃ over D₂ (K_i=353 nM). Dopamine D3 receptor ligand-3 has the potential for Cocaine use disorder (CUD) research.

HY-115954

Dopamine D3 receptor ligand-2	Dopamine Receptor	Neurological Disease
Dopamine D3 receptor ligand-2 (compound 8) is a potent D₃ receptor ligand with a K_i of 11.4 nM. Dopamine D3 receptor ligand-2 have high selectivity for D₃ over D₂ (K_i=1228 nM). Dopamine D3 receptor ligand-2 has the potential for Cocaine use disorder (CUD) research.

HY-B0161AS

Duloxetine D3 hydrochloride (S)-Duloxetine D3 hydrochloride; LY248686 D3 hydrochloride	Serotonin Transporter	Neurological Disease
Duloxetine D3 hydrochloride ((S)-Duloxetine D3 hydrochloride) is a deuterium labeled Duloxetine hydrochloride. Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a K_i of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).

HY-130705

Previtamin D3
VD/VDR Metabolic Disease

Previtamin D3 is an intermediate in the production of cholecalciferol (vitamin D3).

Previtamin D3	VD/VDR	Metabolic Disease
Previtamin D3 is an intermediate in the production of cholecalciferol (vitamin D3).

HY-70050CS

Alosetron D3 Hydrochloride GR-68755C D3	5-HT Receptor	Neurological Disease
Alosetron D3 Hydrochloride (GR-68755C D3) is deuterium labeled Alosetron, which is a serotonin 5HT3-receptor antagonist.

HY-12785S

Albendazole sulfoxide D3 Ricobendazole D3; Albendazole oxide D3	Parasite	Inflammation/Immunology
Albendazole sulfoxide D3 is deuterium labeled Albendazole sulfoxide, which is a broad-spectrum anthelmintic.

HY-N8357

Vitamin D3 octanoate	Endogenous Metabolite	Others
Vitamin D3 octanoate is an octanoate ester of vitamin D3. Vitamin D3 (Cholecalciferol; HY-15398) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.

HY-B0253S

Piroxicam D3 CP-16171 D3	COX	Cancer Inflammation/Immunology
Piroxicam D3 (CP-16171 D3) is deuterium labeled Piroxicam. Piroxicam is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC₅₀s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively .

HY-129240S

13-cis Acitretin D3 Isoacitretin D3; Ro 13-7652 D3	Drug Metabolite	Inflammation/Immunology
13-cis Acitretin D3 （Isoacitretin D3） is a deuterium labeled 13-cis Acitretin. 13-cis Acitretin is the metabolite of Acitretin after chronic administration. Acitretin(Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.

HY-78131AS

(S)-(+)-Ibuprofen D3 (S)-Ibuprofen D3	COX	Inflammation/Immunology
(S)-(+)-Ibuprofen D3 ((S)-Ibuprofen D3) is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC₅₀s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects.

HY-B0352BS

(R)-Mirtazapine D3 (R)-Org3770 D3; (R)-6-Azamianserin D3	5-HT Receptor	Neurological Disease
(R)-Mirtazapine D3 ((R)-Org3770 D3) is a deuterium labeled (R)-Mirtazapine. (R)-Mirtazapine is a R(−)-enantiomer of Mirtazapine with antinociceptive properties in an animal model of acute thermal nociception. (R)-Mirtazapine is a 5-HT₃ receptor antagonist. (R)-Mirtazapine is mainly metabolized by CYP3A4.

HY-B0197AS

Naratriptan D3 Hydrochloride GR-85548A D3	5-HT Receptor	Neurological Disease
Naratriptan D3 Hydrochloride is the deuterium labeled Naratriptan, which is a selective 5-HT1 receptor subtype agonist.

HY-B0352AS

(S)-Mirtazapine D3 (S)-Org3770 D3; (S)-6-Azamianserin D3	5-HT Receptor	Neurological Disease
(S)-Mirtazapine D3 ((S)-Org3770 D3) is a deuterium labeled (S)-Mirtazapine. (S)-Mirtazapine is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception.(S)-Mirtazapine is a stereoselective 5-HT₂ receptor antagonist. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2.

HY-15398

Vitamin D3 Cholecalciferol; Colecalciferol	VD/VDR Endogenous Metabolite	Cancer Metabolic Disease
Vitamin D3 (Cholecalciferol; Colecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.

HY-136540

Resolvin D3 RvD3	Others	Inflammation/Immunology
Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation.

HY-17504BS

Rosuvastatin D3 Sodium	HMG-CoA Reductase (HMGCR) Autophagy	Metabolic Disease Cardiovascular Disease
Rosuvastatin D3 Sodium is deuterium labeled Rosuvastatin, which is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM.

HY-50936S

Trabectedin D3 Ecteinascidin 743 D3; ET-743 D3	Reactive Oxygen Species Apoptosis	Cancer Inflammation/Immunology
Trabectedin D3 (Ecteinascidin 743 D3) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment.

HY-N3519

Platycodin D3
HCV Infection

Platycodin D3 is a triterpenoid saponin isolated from Platycodon grandiflorum, with anti-HCV activity.

Platycodin D3	HCV	Infection
Platycodin D3 is a triterpenoid saponin isolated from Platycodon grandiflorum, with anti-HCV activity.

HY-17504AS

Rosuvastatin D3 ZD 4522 D3	HMG-CoA Reductase (HMGCR) Autophagy Potassium Channel	Metabolic Disease Cardiovascular Disease
Rosuvastatin D3 (ZD 4522 D3) is a deuterium labeled Rosuvastatin. Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC₅₀ of 11 nM. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC₅₀ of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals.

HY-12388AS

N-Desmethyl Clomipramine D3 hydrochloride Desmethylclomipramine D3 hydrochloride	Drug Metabolite	Neurological Disease
N-Desmethyl Clomipramine D3 hydrochloride is the deuterium labeled N-Desmethyl Clomipramine. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine

HY-32351

Calcifediol 25-hydroxy Vitamin D3	VD/VDR Endogenous Metabolite	Metabolic Disease
Calcifediol (25-hydroxy Vitamin D3), a major circulating metabolite of vitamin D3, is a potent VDR inhibitor.

HY-32351A

Calcifediol monohydrate 25-hydroxy Vitamin D3 monohydrate	VD/VDR Endogenous Metabolite	Metabolic Disease
Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), a major circulating metabolite of vitamin D3, is a potent VDR inhibitor.

HY-15254

3-O-(2-Aminoethyl)-25-hydroxyvitamin D3
25-Hydroxy Vitamin D3 3,3’-Aminopropyl Ether
VD/VDR Metabolic Disease

3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 is a Vitamin D3 derivative.
HY-N3520

Deapi-platycodin D3
Others Inflammation/Immunology Metabolic Disease

Deapi-platycodin D3 is a triterpenoid saponin from the roots of Platycodon grandiflorum.

3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 25-Hydroxy Vitamin D3 3,3’-Aminopropyl Ether	VD/VDR	Metabolic Disease
3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 is a Vitamin D3 derivative.

Deapi-platycodin D3	Others	Inflammation/Immunology Metabolic Disease
Deapi-platycodin D3 is a triterpenoid saponin from the roots of Platycodon grandiflorum.

HY-B0439S1

Sulfadoxine D3 Sulphadoxine D3	Parasite HIV Antibiotic	Infection
Sulfadoxine D3 is a deuterium labeled Sulfadoxine. Sulfadoxine is a long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.

HY-124366

Slingshot inhibitor D3	Others	Cancer Infection
Slingshot inhibitor D3 is a potent, selective, reversible and competitive inhibitor of Slingshot. The IC₅₀ value for Slingshot 1 is 3 μM and the K_i value for Slingshot 2 is 3.9 μM. Slingshot inhibitor D3 has similar inhibitory activities toward both Slingshot 1 and Slingshot 2.

HY-32337

Tacalcitol
1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3
VD/VDR Metabolic Disease

Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.

Tacalcitol 1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3	VD/VDR	Metabolic Disease
Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.

HY-139680

Dopamine D3 receptor antagonist-1	Dopamine Receptor	Neurological Disease
Dopamine D3 receptor antagonist-1 is a dopamine D₃ receptor-selective or multitarget bitopic ligand (K_i = 1.58 nM) potentially useful for central nervous system disorders.

HY-139681

Dopamine D3 receptor antagonist-2	Dopamine Receptor	Neurological Disease
Dopamine D3 receptor antagonist-2 is a dopamine D3 receptor-selective (K_i = 2.16 nM) or multitarget bitopic ligand potentially useful for central nervous system disorders.

HY-32338

Tacalcitol monohydrate 1,24(R)-Dihydroxyvitamin D3 monohydrate	VD/VDR	Metabolic Disease
Tacalcitol monohydrate (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) promotes normal bone development by regulating calcium.

HY-17030S

Acamprosate D3 calcium	GABA Receptor	Neurological Disease
Acamprosate D3 calcium is the deuterium labeled Acamprosate calcium. Acamprosate calcium is a GABA receptor agonist and modulator of glutamatergic systems.

HY-15830

25,26-Dihydroxyvitamin D3 25,26-Dihydroxycholecalciferol	VD/VDR Endogenous Metabolite	Others
25,26-Dihydroxyvitamin D3(25,26-dihydroxycholecalciferol) is a metabolite of vitamin D3 with intestinal calcium transport activity.

HY-10003A

1α-Hydroxy-3-epi-vitamin D3	Thyroid Hormone Receptor	Metabolic Disease
1α-Hydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxyvitamin D3, is a potent suppressor of parathyroid hormone (PTH) secretion.

HY-W008772S

4-Hydroxymephenytoin D3	Others	Others
4-Hydroxymephenytoin D3 is the deuterium labeled 4-Hydroxymephenytoin. 4-Hydroxymephenytoin is a metabolism of an antiepileptic drug mephenytoin, which is used as a CYP2C19 substrate.

HY-115953

Dopamine D3 receptor ligand-1	Dopamine Receptor	Neurological Disease
Dopamine D₃ receptor ligand is a potent, selective and high affinity ligand for Dopamine D₃ receptor with 89-fold selective for D₃ over D₂ (D₃ K_i= 8 nM, D₂ K_i= 715 nM).

HY-B1057S

Nefopam D3 hydrochloride	β-catenin	Neurological Disease
Nefopam D3 hydrochloride is the deuterium labeled Nefopam hydrochloride. Nefopam hydrochloride (Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug, for the relief of moderate to severe pain. Nefopam hydrochloride targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo.

HY-B0725S

Doxepin D3 Hydrochloride	Histamine Receptor Cytochrome P450	Neurological Disease
Doxepin D3 Hydrochloride is a deuterium labeled Doxepin Hydrochloride. Doxepin hydrochloride is an orally active tricyclic antidepressant. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2.

HY-15439

(24S)-24,25-Dihydroxyvitamin D3 (24S)-24,25-Dihydroxycholecalciferol	VD/VDR	Others
(24S)-24,25-Dihydroxyvitamin D3 ((24S)-24,25-Dihydroxycholecalciferol) is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs.

HY-133111S

3-Hydroxy agomelatine D3	5-HT Receptor	Neurological Disease
3-Hydroxy agomelatine D3 is a deuterium labeled 3-Hydroxy agomelatine. 3-Hydroxy agomelatine is a 5-HT_2C receptor antagonist with an IC₅₀ of 3.2 μM and a K_i of 1.8 μM.

HY-N0176S

Dihydroartemisinin-d3 Dihydroqinghaosu-D3; β-Dihydroartemisinin-D3; Artenimol-D3	Parasite NF-κB Autophagy Apoptosis	Cancer Infection
Dihydroartemisinin-d3 (Dihydroqinghaosu-d3) is the deuterium labeled Dihydroartemisinin. Dihydroartemisinin is a potent anti-malaria agent.

HY-17413S

Zidovudine-d3 Azidothymidine-D3; AZT-D3; ZDV-D3	HIV CRISPR/Cas9	Infection
Zidovudine-d3 (Azidothymidine-d3) is the deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency.

HY-U00424

Chol-5-en-24-al-3β-ol Vitamin D3 derivative	VD/VDR	Metabolic Disease
Chol-5-en-24-al-3β-ol is a steroid compound (Vitamin D3 derivative) extracted from patent US 4354972 A, Compound IX.

HY-W008794S

Normetanephrine-d3 hydrochloride (±)-Normetanephrine-D3 hydrochloride; DL-Normetanephrine-D3 hydrochloride; (Rac)-Normetanephrine-D3 hydrochloride	Endogenous Metabolite	Metabolic Disease
Normetanephrine-d3 ((±)-Normetanephrine-d3) hydrochloride is the deuterium labeled Normetanephrine hydrochloride. Normetanephrine ((±)-Normetanephrine) hydrochloride is the O-methylated metabolite of norepinephrine (NE).

HY-B1417S

Nortriptyline-d3 hydrochloride Desmethylamitriptyline-D3 hydrochloride; Desitriptilina-D3 hydrochloride	Autophagy Apoptosis Drug Metabolite	Neurological Disease Cancer
Nortriptyline-d3 (Desmethylamitriptyline-d3) hydrochloride is the deuterium labeled Nortriptyline hydrochloride. Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and used to relieve the symptoms of depression.

HY-15830S

25,26-Dihydroxyvitamin D3-d3 25,26-Dihydroxycholecalciferol-D3	VD/VDR Endogenous Metabolite	Others
25,26-Dihydroxyvitamin D3-d3 (25,26-Dihydroxycholecalciferol-d3) is the deuterium labeled 25,26-Dihydroxyvitamin D3. 25,26-Dihydroxyvitamin D3 (25,26-dihydroxycholecalciferol) is a metabolite of vitamin D3 with intestinal calcium transport activity.

HY-B0457AS

Clomipramine-d3 Chlorimipramine-D3; G-34586-D3; NSC-169865-D3	Serotonin Transporter Dopamine Receptor	Neurological Disease
Clomipramine-d3 (Chlorimipramine-d3) is the deuterium labeled Clomipramine. Clomipramine is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with K_i of 0.14, 54 and 3 nM, respectively.

HY-B0457S

Clomipramine-d3 hydrochloride Chlorimipramine-D3 hydrochloride; G-34586-D3 hydrochloride; NSC-169865-D3 hydrochloride	Serotonin Transporter Dopamine Receptor	Neurological Disease
Clomipramine-d3 (Chlorimipramine-d3) hydrochloride is a deuterium labeled Clomipramine hydrochloride. Clomipramine hydrochloride is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with K_i of 0.14, 54 and 3 nM, respectively.

HY-14654S

Aspirin-d3 Acetylsalicylic Acid-D3; ASA-D3	COX Autophagy Mitophagy Virus Protease	Inflammation/Immunology Cancer
Aspirin-d3 (Acetylsalicylic Acid-d3) is the deuterium labeled Aspirin. Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC₅₀s of 5 and 210 μg/mL.

HY-B1037S

Salbutamol-d3 Albuterol-D3; AH-3365-D3	Adrenergic Receptor	Neurological Disease Endocrinology
Salbutamol-d3 (Albuterol-d3) is the deuterium labeled Salbutamol. Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease (COPD).

HY-N0583S3

Hydrocortisone-d3 Cortisol-D3	Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology Cancer
Hydrocortisone-d3 (Cortisol-d3) is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex.

HY-103395S

Methylmalonic acid-d3 Methylpropanedioic acid-D3; Methylmalonate-D3	Endogenous Metabolite	Cancer
Methylmalonic acid-d3 (Methylpropanedioic acid-d3) is the deuterium labeled Methylmalonic acid. Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer.

HY-B0905S

Tilmicosin-d3 LY-177370-D3; EL-870-D3	Bacterial Antibiotic	Infection
Tilmicosin-d3 (LY-177370-d3) is the deuterium labeled Tilmicosin. Tilmicosin is a macrolide antibiotic, is used for the research of bovine respiratory disease and ovine respiratory disease associated with Mannheimia (Pasteurella) haemolytica.

HY-133771AS

Nordoxepin-d3 hydrochloride Desmethyldoxepin-D3 hydrochloride	Drug Metabolite	Neurological Disease
Nordoxepin D3 hydrochloride (Desmethyldoxepin D3 hydrochloride) is the deuterium labeled Nordoxepin hydrochloride. Nordoxepin hydrochloride is an active metabolite of Doxepin hydrochloride (HY-B0725), which is an orally active tricyclic antidepressant.

HY-N0402S

Artemether-d3 Dihydroqinghaosu methyl ether-D3; Dihydroartemisinin methyl ether-D3; SM224-D3	Parasite	Infection Cancer
Artemether-d3 (Dihydroqinghaosu methyl ether-d3) is the deuterium labeled Artemether. Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria.

HY-66005S1

Acetaminophen-d3 Paracetamol-D3; 4-Acetamidophenol-D3; 4'-Hydroxyacetanilide-D3	COX Histone Acetyltransferase Endogenous Metabolite	Inflammation/Immunology
Acetaminophen-d3 (Paracetamol-d3) is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

HY-14598S1

Diethylstilbestrol-d3
Stilbestrol-D3
Estrogen Receptor/ERR Endocrinology Cancer

Diethylstilbestrol-d3 is deuterium labeled Diethylstilbestrol.

HY-13632S2

Exemestane-d3 FCE 24304-D3; EXE-D3	Aromatase	Cancer Endocrinology
Exemestane-d3 (FCE 24304-d3) is the deuterium labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC₅₀s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research.

HY-N1150S

Thymidine-d3 DThyd-D3; NSC 21548-D3	DNA/RNA Synthesis Endogenous Metabolite	Others
Thymidine-d3 (DThyd-d3) is the deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.

HY-A0088S

Cefotaxime-d3 sodium Cefotaxim-D3 sodium; HR-756-D3 sodium	Bacterial Antibiotic	Infection
Cefotaxime-d3 (Cefotaxim-d3) sodium is the deuterium labeled Cefotaxime (sodium salt). Cefotaxime sodium salt, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria.

HY-15027S

5-Aminosalicylic Acid-D3 hydrochloride Mesalamine-D3 hydrochloride; 5-ASA-D3 hydrochloride; Mesalazine-D3 hydrochloride	PPAR PAK NF-κB Endogenous Metabolite	Inflammation/Immunology Cancer
5-Aminosalicylic Acid-D3 (Mesalamine-D3) hydrochloride is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) hydrochloride acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.

HY-132348S1

Granisetron-d3 (1-methyl-d3)

Granisetron-d3 (1-methyl-d3) 是 Granisetron氘代物。

HY-10219S

Rapamycin-d3 Sirolimus-D3; AY-22989-D3	mTOR FKBP Autophagy	Cancer
Rapamycin-d3 (Sirolimus-d3) is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC₅₀of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.

HY-N0650S8

L-Serine-d3 (-)-Serine-D3; (S)-Serine-D3	Endogenous Metabolite	Cancer
L-Serine-d3 ((-)-Serine-d3) is the deuterium labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-13683S

Mifepristone-d3 RU486-D3; RU 38486-D3	Progesterone Receptor Glucocorticoid Receptor NO Synthase Autophagy	Endocrinology Cancer
Mifepristone-d3 (RU486-d3) is the deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC₅₀s of 0.2 nM and 2.6 nM in in vitro assay.

HY-15315S1

Baricitinib-d3 LY3009104-D3; INCB028050-D3	JAK	Inflammation/Immunology
Baricitinib-d3 (LY3009104-d3) is the deuterium labeled Baricitinib. Baricitinib (LY3009104; INCB028050) is a selective and orally bioavailable JAK1 and JAK2 inhibitor with IC₅₀s of 5.9 nM and 5.7 nM, respectively.

HY-N0415S

Trigonelline-d3 chloride Trigonelline-D3 hydrochloride	HSV Bacterial Fungal	Cancer Infection Metabolic Disease
Trigonelline-d3 chloride (Trigonelline-d3 hydrochloride) is the deuterium labeled Trigonelline chloride. Trigonelline chloride, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. Trigonelline chloride has anti-HSV-1 , antibacterial, and antifungal activities.

HY-B1057S2

Nefopam-d3 Fenazoxine-D3	β-catenin	Neurological Disease
Nefopam D3 (Fenazoxine D3) is a deuterium labeled Nefopam (Fenazoxine). Nefopam is a centrally-acting but non-opioid analgesic drug, and Nefopam targets β-catenin protein level in mesenchymal cells.

HY-70050AS

Alosetron-d3
GR 68755-D3; GR 68755X-D3
5-HT Receptor Neurological Disease

Alosetron-d3 (GR 68755-d3) is a deuterium labeled Alosetron. Alosetron is a serotonin 5HT3-receptor antagonist.

HY-B1374S1

Florfenicol-d3 (-)-Florfenicol-D3; SCH-25298-D3	Bacterial Antibiotic	Infection
Florfenicol-d3 ((-)-Florfenicol-d3) is the deuterium labeled Florfenicol. Florfenicol, a commonly used veterinary antibiotic, is currently indicated for bovine respiratory disease, and also used in aquaculture for the control of enteric septicemia in catfish. Florfenicol can induce early embryonic death in eggs, with an LC₅₀ of 1.07 μg/g.

HY-121309S

Doxorubicinone-d3 Adriamycin aglycone-D3; Adriamycinone-D3	Endogenous Metabolite	Cancer
Doxorubicinone-d3 (Adriamycin aglycone-d3) is the deuterium labeled Doxorubicinone. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin. Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively.

HY-N0680S1

Thiamine-d3 hydrochloride Thiamine chloride-D3 hydrochloride; Vitamin B1-D3 hydrochloride	Endogenous Metabolite Apoptosis HBV	Neurological Disease
Thiamine-d3 (Thiamine chloride-d3) hydrochloride is the deuterium labeled Thiamine hydrochloride. Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.

HY-12053AS

Vinorelbine-d3 ditartrate KW-2307-D3 ditartrate; Nor-5'-anhydrovinblastine-D3 ditartrate	Microtubule/Tubulin Autophagy	Cancer
Vinorelbine-d3 (KW-2307-d3) ditartrate is the deuterium labeled Vinorelbine ditartrate. Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC₅₀ of 1.25 nM.

HY-B0456S3

Riboflavin-d3 Vitamin B2-D3; E101-D3	Endogenous Metabolite	Others
Riboflavin-d3 (Vitamin B2-d3) is the deuterium labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.

HY-41700S

D-Alanine-d3 (R)-Alanine-D3; Ba 2776-D3; D-α-Alanine-D3	Endogenous Metabolite	Others
D-Alanine-d3 ((R)-Alanine-d3) is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.

HY-B1051S

Flumethasone-d3 Flumetasone-D3	Fungal	Inflammation/Immunology
Flumethasone-d3 (Flumetasone-d3) is the deuterium labeled Flumethasone. Flumethasone is a corticosteroid for topical use, in combination with Clioquinol for the treatment of otitis externa and otomycosis. Flumethasone shows fully 420 times the potency of cortisone in an animal model for anti-inflammatory activity.

HY-B0504S

Creatinine-d3 NSC13123-D3	Endogenous Metabolite	Metabolic Disease
Creatinine-D3 (NSC13123-D3) is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle.

HY-B1743S

Puromycin-d3 CL13900-D3	Bacterial Antibiotic	Infection
Puromycin-d3 (CL13900-d3) is the deuterium labeled Puromycin. Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.

HY-13272S

Dacomitinib-d3 PF-00299804-D3; PF-299804-D3	EGFR Apoptosis	Cancer
Dacomitinib-d3 (PF-00299804-d3) is the deuterium labeled Dacomitinib. Dacomitinib (PF-00299804) is a specific and irreversible inhibitor of the ERBB family of kinases with IC₅₀s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively.

HY-B1398S

Ampyrone-d3 4-Aminoantipyrine-D3	COX Drug Metabolite	Others
Ampyrone-d3 (4-Aminoantipyrine-d3) is the deuterium labeled Ampyrone. Ampyrone is a reagent for glucose determination in the presence of peroxidase and phenol.

HY-B1743AS

Puromycin-d3 dihydrochloride CL13900-D3 dihydrochloride	Bacterial Antibiotic	Infection
Puromycin-d3 (CL13900-d3) dihydrochloride is the deuterium labeled Puromycin dihydrochloride. Puromycin dihydrochloride (CL13900 dihydrochloride), an aminonucleoside antibiotic, inhibits protein synthesis.

HY-17016S1

Oseltamivir-d3 phosphate GS 4104-D3 phosphate	Influenza Virus	Infection
Oseltamivir-d3 (GS 4104-d3) phosphateis the deuterium labeled Oseltamivir phosphate. Oseltamivir phosphate (GS 4104) is a neuraminidase inhibitor recommended for the treatment and prophylaxis of influenza A and B.

HY-B0276S

Ethionamide-d3 2-ethylthioisonicotinamide-D3	Bacterial Antibiotic	Infection
Ethionamide-d3 (2-ethylthioisonicotinamide-d3) is the deuterium labeled Ethionamide. Ethionamide (2-ethylthioisonicotinamide) is an antibiotic used in the treatment of tuberculosis.

HY-13636S

Fulvestrant-d3 ICI 182780-D3; ZD 9238-D3; ZM 182780-D3	Estrogen Receptor/ERR Autophagy Apoptosis	Cancer
Fulvestrant-d3 (ICI 182780-d3) is the deuterium labeled Fulvestrant. Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC₅₀ of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC₅₀ of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy.

HY-17039S

Alcaftadine-D3 R89674-D3	Histamine Receptor	Endocrinology Inflammation/Immunology
Alcaftadine-D3 (R89674-D3) is a deuterium labeled Alcaftadine. Alcaftadine (HY-17039) is a H1 histamine receptor antagonist.

HY-B0740S

Cyclobenzaprine-d3 hydrochloride MK130-D3 hydrochloride	5-HT Receptor	Neurological Disease
Cyclobenzaprine-d3 (MK130-d3) hydrochloride is the deuterium labeled Cyclobenzaprine hydrochloride. Cyclobenzaprine hydrochloride (MK130 hydrochloride) is a skeletal muscle relaxant and a central nervous system (CNS) depressant.

HY-17034BS

Medetomidine-d3 hydrochloride MPV785-D3	Adrenergic Receptor	Neurological Disease Endocrinology
Medetomidine-d3 hydrochloride (MPV785-d3) is the deuterium labeled Medetomidine hydrochloride. Medetomidine hydrochloride is an agonist of adrenergic alpha-2 receptor.

HY-10353AS

Raltegravir-d3 potassium MK 0518-D3 potassium	HIV Integrase HIV	Infection
Raltegravir-d3 potassium (MK 0518-d3 potassium) is the deuterium labeled Raltegravir potassium. Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection.

HY-N0682S

Pyridoxine-d3 hydrochloride Pyridoxol-D3 hydrochloride; Vitamin B6-D3 hydrochloride	Endogenous Metabolite Keap1-Nrf2	Neurological Disease
Pyridoxine-d3 (Pyridoxol-d3) hydrochloride is the deuterium labeled Pyridoxine hydrochloride. Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-101037S1

Sarcosine-d3 N-Methylglycine-D3; Sarcosin-D3	Endogenous Metabolite GlyT	Cancer
Sarcosine-d3 (N-Methylglycine-d3) is the deuterium labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].

HY-70037S

Cinacalcet-D3 AMG 073-D3	CaSR Endogenous Metabolite	Cardiovascular Disease
Cinacalcet-D3 (AMG 073-D3) is the deuterium labeled Cinacalcet. Cinacalcet (AMG 073) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.

HY-Y1311S

Malic acid-d3 Hydroxybutanedioic acid-D3; E 296-D3	Endogenous Metabolite	Others
Malic acid-d3 (Hydroxybutanedioic acid-d3) is the deuterium labeled Malic acid. Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods.

HY-Y0842S1

Formamide-d3 Methanamide-D3; Formimidic acid-D3	Endogenous Metabolite	Others
Formamide-d3 is the deuterium labeled Formamide. Formamide is an amide derived from formic acid and has been used as solvent for many ionic compounds.

HY-15025S

Sildenafil-d3 UK-92480-D3	Phosphodiesterase (PDE)	Cancer Cardiovascular Disease
Sildenafil-d3 is deuterium labeled Sildenafil-d3. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC₅₀ of 5.22 nM.

HY-141776S

Omeprazole sulfide-d3 Ufiprazole-D3	Drug Metabolite	Others
Omeprazole sulfide-d3 (Ufiprazole-d3) is the deuterium labeled Omeprazole sulfide. Omeprazole metabolite Omeprazole sulfide (Ufiprazole) is a metabolite of Omeprazole, which is a proton pump inhibitor.

HY-70037AS

Cinacalcet-d3 hydrochloride AMG 073-D3 hydrochloride	CaSR Endogenous Metabolite	Cardiovascular Disease
Cinacalcet-D3 (AMG 073-D3) hydrochloride is the deuterium labeled Cinacalcet (hydrochloride). Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.

HY-12857S1

Brigatinib-d3 AP-26113-D3	ALK	Cancer
Brigatinib-d3 (AP-26113-d3) is the deuterium labeled Brigatinib. Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor, with an IC₅₀ of 0.6 nM.

HY-13318S

Oseltamivir acid-d3 GS 4071-D3; Ro 64-0802-D3; Oseltamivir carboxylate-D3	Influenza Virus	Infection
Oseltamivir acid D3 (GS 4071 D3) is a deuterium labeled Oseltamivir acid. Oseltamivir acid, the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC₅₀=2 nM) with activity against both influenza A and B viruses.

HY-N0282S1

Colcemid-d3 Demecolcine-D3	Microtubule/Tubulin	Cancer Inflammation/Immunology
Colcemid-d3 (Demecolcine-d3) is the deuterium labeled Colcemid. Colcemid (Demecolcine), a derivative of colchicine, is a potent mitotic inhibitor. Colcemid binds to the protein tubulin and arrest cells in metaphase for karyotyping assays. Colcemid incuces cell apoptosis and can be used for cancer research.

HY-B0471S

Phenylephrine-d3 hydrochloride (R)-(-)-Phenylephrine-D3 hydrochloride; L-Phenylephrine-D3 hydrochloride	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Phenylephrine-d3 (R)-(-)-Phenylephrine-d3) hydrochloride is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α₁-adrenoceptor agonist with pK_is of 5.86, 4.87 and 4.70 for α_1D, α_1B and α_1A receptors respectively.

HY-B0412S4

Estriol-d3-1
Oestriol-D3-1
Estrogen Receptor/ERR Endogenous Metabolite Cancer

Estriol-d3-1 (Oestriol-d3-1) is the deuterium labeled Estriol.

HY-B0617S

S-Adenosyl-L-methionine-d3 S-Adenosyl methionine-D3; Ademetionine-D3; AdoMet-D3	Endogenous Metabolite	Cancer Inflammation/Immunology Neurological Disease
S-Adenosyl-L-methionine D3 (S-Adenosyl methionine D3) is a deuterium labeled S-Adenosyl-L-methionine. S-Adenosyl-L-methionine is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor.

HY-N1354S

Reynoutrin-d3 Quercetin-3-D-xyloside-D3; Reinutrin-D3	Reactive Oxygen Species	Metabolic Disease
Reynoutrin-d3 (Quercetin-3-D-xyloside-d3) is the deuterium labeled Reynoutrin. Reynoutrin (Quercetin-3-D-xyloside) is a flavonoid from Psidium cattleianum, with antioxidant and radical-scavenging activity.

HY-B0192S2

Alfuzosin-d3
SL 77499-D3
Adrenergic Receptor Endocrinology

Alfuzosin-d3 is deuterium labeled Alfuzosin.

HY-B0251S

Eplerenone-d3 Epoxymexrenone-D3	Mineralocorticoid Receptor Endogenous Metabolite	Cardiovascular Disease
Eplerenone-d3 (Epoxymexrenone-d3) is the deuterium labeled Eplerenone. Eplerenone (Epoxymexrenone) is a selective, competitive and oreally active aldosterone antagonist with an IC₅₀ of 138 nM. Eplerenone has low affinity for progesterone, androgen, estrogen and glucocorticoid receptors. Eplerenone can be used for hypertension and heart failure after myocardial infarction reserch.

HY-14398S1

Celecoxib-d3 SC 58635-D3	COX	Inflammation/Immunology Cancer
Celecoxib-d3 (SC 58635-d3) is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

HY-50910S

Temsirolimus-d3 CCI-779-D3	mTOR Autophagy Apoptosis	Cancer
Temsirolimus-d3 (CCI-779-d3) is the deuterium labeled Temsirolimus. Temsirolimus is an inhibitor of mTOR with an IC₅₀ of 1.76 μM. Temsirolimus activates autophagy and prevents deterioration of cardiac function in animal model.

HY-107854S

N-Acetyl-5-hydroxytryptamine-d3 N-Acetylserotonin-D3; Normelatonin-D3; O-Demethylmelatonin-D3	Endogenous Metabolite Trk Receptor	Neurological Disease
N-Acetyl-5-hydroxytryptamine-d3 (N-Acetylserotonin-d3) is the deuterium labeled N-Acetyl-5-hydroxytryptamine. N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor.

HY-15247S

Vistusertib-d3 AZD2014-D3	mTOR Autophagy Apoptosis	Cancer
Vistusertib-d3 (AZD2014-d3) is the deuterium labeled Vistusertib. Vistusertib (AZD2014) is an ATP competitive mTOR inhibitor with an IC₅₀ of 2.81 nM. AZD2014 inhibits both mTORC1 and mTORC2 complexes.

HY-108251S

Methotrexate metabolite-d3 DAMPA-D3	Antifolate Drug Metabolite	Inflammation/Immunology
Methotrexate metabolite-d3 (DAMPA-d3) is the deuterium labeled Methotrexate metabolite. Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent.

HY-N0623S9

L-Tryptophan-d3 Tryptophan-D3; Tryptophane-D3	Endogenous Metabolite
L-Tryptophan-d3 is the deuterium labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3.

HY-A0064S

Verapamil-d3 hydrochloride (±)-Verapamil-D3 hydrochloride; CP-16533-1-D3 hydrochloride	Calcium Channel P-glycoprotein Cytochrome P450	Cardiovascular Disease
Verapamil-d3 ((±)-Verapamil-d3) hydrochloride is the deuterium labeled Verapamil hydrochloride. Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits *CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research.*

HY-12519S

Oltipraz-d3 RP 35972-D3; NSC 347901-D3	HIF/HIF Prolyl-Hydroxylase HIV Keap1-Nrf2	Cancer
Oltipraz-d3 (RP 35972-d3) is the deuterium labeled Oltipraz. Oltipraz has an inhibitory effect on HIF-1α activation in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC₅₀ of Oltipraz for HIF-1α inhibition is 10 μM. Oltipraz is a potent Nrf2 activator.

HY-B0559S

Nabumetone-d3 BRL14777-D3	COX	Inflammation/Immunology Cancer
Nabumetone-d3 (BRL14777-d3) is the deuterium labeled Nabumetone. Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the prodrug of the active metabolite 6MNA.

HY-N0504S2

Lovastatin-d3 Mevinolin-D3	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Lovastatin-d3 is deuterium labeled Lovastatin. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-15592S

Cabotegravir-d3 GSK-1265744-D3; S/GSK1265744-D3	HIV HIV Integrase	Infection
Cabotegravir-d3 (GSK-1265744-d3) is the deuterium labeled Cabotegravir. Cabotegravir is a potent HIV integrase inhibitor as an oral lead-in tablet and long-acting injectable for the treatment and prevention of HIV infection. Cabotegravir is an inhibitor of OAT1 (IC₅₀ 0.81 μM) and OAT3 (IC₅₀ 0.41 μM).

HY-119433S

Asoprisnil-d3 J867-D3	Progesterone Receptor	Endocrinology
Asoprisnil-d3 (J867-d3) is the deuterium labeled Asoprisnil. Asoprisnil (J867), a selective progesterone receptor modulator, exhibits mixed progesterone agonist and antagonist effects on various progesterone targeted tissues in animal and human.

HY-75087S

(R)-Pyrrolidine-2-carboxylic acid-d3 (+)-(R)-Proline-D3; (R)-(+)-Proline-D3; (R)-2-Carboxypyrrolidine-D3; (R)-Proline-D3	Endogenous Metabolite	Metabolic Disease
(R)-Pyrrolidine-2-carboxylic acid-d3 ((+)-(R)-Proline-d3) is the deuterium labeled (R)-pyrrolidine-2-carboxylic acid. (R)-pyrrolidine-2-carboxylic acid is an endogenous metabolite.

HY-N1914S

Ergothioneine-d3 L-(+)-Ergothioneine-D3	Endogenous Metabolite	Others
Ergothioneine-d3 (L-(+)-Ergothioneine-d3) is the deuterium labeled Ergothioneine. Ergothioneine, an imidazole-2-thione derivative of histidine betaine, is synthesized by certain bacteria and fungi. Ergothioneine is generally considered an antioxidant.

HY-N6608S

Physostigmine-d3 Eserine-D3	AChE	Neurological Disease
Physostigmine-d3 (Eserine-d3) is the deuterium labeled Physostigmine. Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning.

HY-12432S

Gilteritinib-d3 ASP2215-D3	FLT3 TAM Receptor	Cancer
Gilteritinib-d3 (ASP2215-d3) is the deuterium labeled Gilteritinib. Gilteritinib (ASP2215) is a potent and ATP-competitive *FLT3/AXL* inhibitor with IC₅₀s of 0.29 nM/0.73 nM, respectively.

HY-10163S1

Dabigatran-d3 BIBR 953-D3; BIBR 953ZW-D3	Thrombin	Cardiovascular Disease
Dabigatran-d3 (BIBR 953-d3) is the deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (K_i=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC₅₀=10 nM).

HY-14291S

Vildagliptin-d3 LAF237-D3; NVP-LAF 237-D3	Dipeptidyl Peptidase Ferroptosis Apoptosis	Metabolic Disease
Vildagliptin-d3 (LAF237-d3) is the deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity.

HY-B0260S

Methylprednisolone-d3 U 7532-D3	Glucocorticoid Receptor Autophagy SARS-CoV	Cancer Infection Endocrinology Inflammation/Immunology
Methylprednisolone-d3 (U 7532-d3) is the deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels.

HY-10984S1

Pomalidomide-d3 CC-4047-D3	Ligands for E3 Ligase Molecular Glues Apoptosis	Cancer
Pomalidomide-d3 (CC-4047-d3) is the deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors.

HY-N1380S1

Guaiacol-d3 2-Methoxyphenol-D3	COX NF-κB	Inflammation/Immunology
Guaiacol-d3 (2-Methoxyphenol-d3) is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Guaiacol has an anti-inflammatory activity.

HY-12515AS

Nicardipine-d3 hydrochloride YC-93-D3	Calcium Channel	Neurological Disease
Nicardipine D3 hydrochloride (YC-93 D3) is the deuterium labeled Nicardipine hydrochloride. Nicardipine hydrochloride is a calcium channel blocker with an IC₅₀ of 1 μM for blocking cardiac calcium channels. Nicardipine hydrochloride acts as an agent for chronic stable angina and for controlling blood pressure.

HY-90009S

Tadalafil-d3 IC-351-D3	Phosphodiesterase (PDE)	Cardiovascular Disease
Tadalafil-d3 (IC-351-d3) is the deuterium labeled Nortadalafil. Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.

HY-A0171AS

Benzoctamine-d3 hydrochloride Ba-30803-D3	5-HT Receptor	Neurological Disease
Benzoctamine-d3 hydrochloride (Ba-30803-d3) is the deuterium labeled Benzoctamine hydrochloride. Benzoctamine hydrochloride (Ba-30803) is a psychoactive agent with anti-anxiety effect. Benzoctamine hydrochloride blocks the central postsynaptic serotonin receptors and decreases 5-HT turnover in the brain.

HY-15284S1

Prasugrel-d3 PCR 4099-D3	P2Y Receptor	Cardiovascular Disease
Prasugrel-d3 (PCR 4099-d3) is the deuterium labeled Prasugrel. Prasugrel (PCR 4099), a thienopyridine and prodrug, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation.

HY-18342S

Diflunisal-d3 MK-647-D3	COX	Inflammation/Immunology Cancer
Diflunisal-d3 (MK-647-d3) is the deuterium labeled Diflunisal. Diflunisal (MK-647) is a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients. The mechanism of action of diflunisal is as a Cyclooxygenase (COX) Inhibitor.

HY-10331S

Regorafenib-d3 BAY 73-4506-D3	VEGFR Autophagy PDGFR Raf RET	Cancer
Regorafenib D3 (BAY 73-4506 D3) is a deuterium labeled Regorafenib. Regorafenib is a multi-targeted receptor tyrosine kinase inhibitor.

HY-B0469S

Medroxyprogesterone acetate-d3 Medroxyprogesterone 17-acetate-D3; Farlutin-D3	Progesterone Receptor Androgen Receptor Glucocorticoid Receptor	Cancer Endocrinology
Medroxyprogesterone acetate D3 is deuterium labeled Medroxyprogesterone acetate. Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors.

HY-B1140S

Diazoxide-d3 Sch-6783-D3; SRG-95213-D3	Potassium Channel Autophagy	Cardiovascular Disease
Diazoxide-d3 is deuterium labeled Diazoxide. Diazoxide (Sch-6783) is an ATP-sensitive potassium channel activator, has the potential for hyperinsulinism treatment.

HY-15123S

(S)-Flurbiprofen-d3 Esflurbiprofen-D3	COX PGE synthase	Inflammation/Immunology
(S)-Flurbiprofen-d3 (Esflurbiprofen-d3) is the deuterium labeled (S)-Flurbiprofen. (S)-Flurbiprofen is an active enantiomer of Flurbiprofen, with IC₅₀ values of 0.48 μM and 0.47 μM for COX-1 and COX-2, respectively.

HY-10191S

Linsitinib-d3 OSI-906-D3	IGF-1R Insulin Receptor	Cancer Endocrinology
Linsitinib-d3 (OSI-906-d3) is the deuterium labeled Linsitinib. Linsitinib (OSI-906) is a potent, selective and orally bioavailable dual inhibitor of the IGF-1 receptor and insulin receptor (IR) with IC₅₀s of 35 and 75 nM, respectively.

HY-N0488S

Vincristine-d3 sulfate Leurocristine-D3 sulfate; NSC-67574-D3 sulfate; 22-Oxovincaleukoblastine-D3 sulfate	Microtubule/Tubulin Apoptosis	Cancer
Vincristine-d3 (Leurocristine-d3) sulfate is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a K_i of 85 nM.

HY-N0776S

Isorhamnetin-d3 3'-Methylquercetin-D3	MEK PI3K Endogenous Metabolite	Cancer Inflammation/Immunology Cardiovascular Disease
Isorhamnetin-d3 (3'-Methylquercetin-d3) is the deuterium labeled Isorhamnetin. Isorhamnetin is a flavonoid compound extracted from the Chinese herb Hippophae rhamnoides L.. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and *PI3K*.

HY-B0561S1

Spironolactone-d3 SC9420-D3	Mineralocorticoid Receptor Androgen Receptor Autophagy	Metabolic Disease Cancer
Spironolactone-d3 (SC9420-d3) is the deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC₅₀ of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC₅₀ of 77 nM. Spironolactone promotes autophagy in podocytes.

HY-32735S

Triptolide-d3 PG490-D3	NF-κB Apoptosis	Cancer
Triptolide-d3 (PG490-d3) is the deuterium labeled Triptolide. Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor.

HY-10448S1

Capsaicin-d3 (E)-Capsaicin-D3	TRP Channel Autophagy Apoptosis Endogenous Metabolite	Cancer
Capsaicin-d3 ((E)-Capsaicin-d3) is the deuterium labeled Capsaicin. Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects.

HY-B0391S

Naftopidil-d3 KT-611-D3; BM-15275-D3	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Naftopidil-d3 (KT-611-d3) is the deuterium labeled Naftopidil. Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with K_is of 3.7 nM, 20 nM and 1.2 nM for the cloned human α_1a-, α_1b- and α_1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia.

HY-N0471S

L-Hyoscyamine-d3 Daturine-D3	mAChR	Neurological Disease
L-Hyoscyamine-d3 (Daturine-d3) is the deuterium labeled L-Hyoscyamine. L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205).

HY-14289S

Cimetidine-d3 SKF-92334-D3	Histamine Receptor	Cancer Endocrinology
Cimetidine-d3 (SKF-92334-d3) is the deuterium labeled Cimetidine. Cimetidine (SKF-92334) is an orally active and inverse histamine H2 receptor antagonist with a K_i of 0.6 μM. Cimetidine is an inverse agonist. Cimetidine has anti-cancer and anti-inflammatory activity.

HY-17485S

Alminoprofen-d3 EB-382-D3	Phospholipase COX	Inflammation/Immunology
Alminoprofen-d3 (EB-382-d3) is the deuterium labeled Alminoprofen. Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class. Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both secretory phospholipase A₂ (sPLA₂) and COX-2.

HY-15762S

Valdecoxib-d3 SC 65872-D3	COX Endogenous Metabolite	Inflammation/Immunology
Valdecoxib-d3 (SC 65872-d3) is the deuterium labeled Valdecoxib. Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC₅₀s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain.

HY-10065S1

Axitinib-d3 AG-013736-D3	VEGFR	Cancer
Axitinib-d3 (AG-013736-d3) is deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC₅₀s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, *VEGFR3* and PDGFRβ, respectively.

HY-B0227S

Ketoprofen-d3 RP-19583-D3	COX Apoptosis	Inflammation/Immunology
Ketoprofen-d3 (RP-19583-d3) is the deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC₅₀s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively.

HY-B0188AS

Mianserin-d3 hydrochloride Org GB 94-D3	Histamine Receptor	Neurological Disease Endocrinology
Mianserin-d3 hydrochloride (Org GB 94-d3) is the deuterium labeled Mianserin hydrochloride. Mianserin hydrochloride (Org GB 94) is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.

HY-G0007S

Omeprazole metabolite Omeprazole sulfone-d3 Omeprazole sulfone-D3; Omeprazole sulphone-D3	Drug Metabolite	Cancer Infection
Omeprazole metabolite Omeprazole sulfone-d3 (Omeprazole sulfone-d3) is the deuterium labeled Omeprazole metabolite Omeprazole sulfone. Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor.

HY-W012480S

DL-Tryptophan-d3
(±)-Tryptophan-D3
Endogenous Metabolite

DL-Tryptophan-d3 is the deuterium labeled DL-Tryptophan. DL-Tryptophan is an endogenous metabolite.

HY-14850S

Sograzepide-d3 Netazepide-D3; YF 476-D3; YM-220-D3	Cholecystokinin Receptor	Metabolic Disease Endocrinology
Sograzepide-d3 (Netazepide-d3) is the deuterium labeled Sograzepide. Sograzepide (Netazepide; YF 476; YM-220) is an extremely potent , highly selective and orally active Gastrin/CCK-B antagonist with an IC₅₀ value of 0.1 nM, has inhibitory effect on Gastrin/CCK-A activity with an IC₅₀ of 502 nM. Sograzepide (Netazepide; YF 476; YM-220) replaces the specific binding of [125I]CCK-8 to the rat brain, cloned canine and cloned human Gastrin/CCK-B receptors, with K_i values of 0.068, 0.62 and 0.19 nM, respectively.

HY-B0311AS

Carbidopa-d3 monohydrate (S)-(-)-Carbidopa-D3 monohydrate	Aryl Hydrocarbon Receptor	Cancer Neurological Disease
Carbidopa-d3 ((S)-(-)-Carbidopa-d3) monohydrate is the deuterium labeled Carbidopa monohydrate. Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth.

HY-13693S

Mometasone furoate-d3 Sch32088-D3	Glucocorticoid Receptor	Endocrinology Inflammation/Immunology
Mometasone furoate-d3 (Sch32088-d3) is a deuterium labeled Mometasone furoate. Mometasone furoate (Sch32088) is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic activity.

HY-B0215S

Acetylcysteine-d3 N-Acetylcysteine-D3; N-Acetyl-L-cysteine-D3; NAC-D3	Reactive Oxygen Species Endogenous Metabolite Apoptosis Ferroptosis Influenza Virus	Infection Neurological Disease
Acetylcysteine-d3 (N-Acetylcysteine-d3) is the deuterium labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor[1]. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases[5]. Acetylcysteine induces cell apoptosis[2][3]. Acetylcysteine also has anti-influenza virus activities[7].

HY-17395S

Terbinafine-d3 hydrochloride TDT 067-D3 hydrochloride	Fungal Bacterial Antibiotic	Infection
Terbinafine-d3 (TDT 067-d3) hydrochloride is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a K_i of 30 nM. Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria.

HY-78131S

Ibuprofen-d3
(±)-Ibuprofen-D3
COX Inflammation/Immunology

Ibuprofen D3 is a deuterium labeled Ibuprofen. Ibuprofen is a COX-1 and COX-2 inhibitor with IC₅₀s of 13 μM and 370 μM.

HY-B1832S

Prednisone acetate-d3 Prednisone 21-acetate-D3	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
Prednisone acetate-d3 (Prednisone 21-acetate-d3) is the deuterium labeled Prednisone acetate. Prednisone acetate (Prednisone 21-acetate), the acetate salt form of prednisolone, is a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties.

HY-N0138S1

Theobromine-d3 3,7-Dimethylxanthine-D3	Adenosine Receptor Endogenous Metabolite	Neurological Disease
Theobromine-d3 (3,7-Dimethylxanthine-d3) is the deuterium labeled Theobromine. Theobromine is a methylxanthine found in cacao beans which can inhibit adenosine receptor A1 (AR1) signaling.

HY-W007355S

Skatole-d3 3-Methylindole-D3; 3-Methyl-1H-indole-D3	Aryl Hydrocarbon Receptor p38 MAPK Endogenous Metabolite Autophagy Bacterial Fungal	Others
Skatole-d3 (3-Methylindole-d3) is the deuterium labeled Skatole. Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.

HY-N0384S

Homovanillic acid-d3 Vanilacetic acid-D3	Endogenous Metabolite	Metabolic Disease
Homovanillic acid-d3 (Vanilacetic acid-d3) is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.

HY-41417S1

Octanoic acid-d3 Caprylic acid-D3	Endogenous Metabolite	Metabolic Disease
Octanoic acid-d3 (Caprylic acid-d3) is the deuterium labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.

HY-76200S

Voriconazole-d3 UK-109496-D3	Fungal	Infection
Voriconazole-d3 (UK-109496-d3) is the deuterium labeled Voriconazole. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes.

HY-10512S

AR-A014418-d3 AR 0133418-D3; GSK 3β inhibitor VIII-D3; AR 014418-D3	GSK-3	Cancer Metabolic Disease
AR-A014418-d3 (AR 0133418-d3) is the deuterium labeled AR-A014418. AR-A014418 is a potent, selective, and ATP-competitive *GSK3β* inhibitor (IC₅₀=104 nM; K_i=38 nM).

HY-78131BS

(R)-(-)-Ibuprofen-d3 (R)-Ibuprofen-D3	NF-κB	Inflammation/Immunology Cancer
(R)-(-)-Ibuprofen-d3 ((R)-Ibuprofen-d3) is the deuterium labeled (R)-(-)-Ibuprofen. (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.

HY-B0113S

Omeprazole-d3 H 16868-D3	Proton Pump Bacterial Autophagy	Cancer Infection Metabolic Disease
Omeprazole D3 (H 16868 D3) is deuterium labeled Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a K_i of 2 to 6 μM. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria.

HY-10121S

Asenapine-d3 Org 5222-D3	5-HT Receptor Adrenergic Receptor Dopamine Receptor Histamine Receptor	Neurological Disease Endocrinology
Asenapine-d3 (Org 5222-d3) is the deuterium labeled Asenapine. Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i: 8.9-9.5), dopamine receptors (pK_i: 8.9-9.4) and histamine receptors (pK_i: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder.

HY-19489S1

(Rac)-Levomepromazine-d3 hydrochloride (Rac)-Methotrimeprazine-D3 hydrochloride	Dopamine Receptor Histamine Receptor	Neurological Disease
(Rac)-Levomepromazine-d3 ((Rac)-Methotrimeprazine-d3) hydrochloride is a labelled racemic Methotrimeprazine, which is a phenothiazine which has antagonist actions at multiple neurotransmitter receptor sites, including dopaminergic, cholinergic, serotonin and histamine receptors.

HY-13694S

Methionine-d3 MRX-1024-D3; D-Methionine-D3	GABA Receptor Endogenous Metabolite	Cancer
Methionine-d3 is the deuterium labeled Methionine. Methionine (MRX-1024; D-Methionine) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor activation.

HY-W004282S1

Undecanoic acid-d3 Undecanoate-D3; Hendecanoic acid-D3	Fungal Endogenous Metabolite
Undecanoic acid-d3 is the deuterium labeled Undecanoic acid. Undecanoic acid (Undecanoate) is a monocarboxylic acid with antimycotic property, which inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum.

HY-15206S1

Glyburide-d3 Glyburide-D3	Potassium Channel Mitochondrial Metabolism Autophagy CFTR P-glycoprotein	Metabolic Disease
Glyburide-d3 (Glyburide-d3) is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K⁺ channel (K_ATP) inhibitor and can be used for the research of diabetes and obesity. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of K_ATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR). Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability. Glibenclamide can induce autophagy.

HY-B0107S

Acitretin-d3 Ro 10-1670-D3	RAR/RXR Autophagy Apoptosis	Inflammation/Immunology Cancer
Acitretin-d3 (Ro 10-1670-d3) is the deuterium labeled Acitretin. Acitretin (Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis. Acitretin also can be used for the research of Alzheimer’s disease.

HY-B0479S

Thiamphenicol-d3 Thiophenicol-D3; Dextrosulphenidol-D3	Bacterial Antibiotic	Infection
Thiamphenicol-d3 is deuterium labeled Thiamphenicol. Thiamphenicol (Thiophenicol), a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria).

HY-50904S

Nintedanib-d3 BIBF 1120-D3	PDGFR VEGFR FGFR	Cancer
Nintedanib-d3 (BIBF 1120-d3) is the deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for *VEGFR1/2/3, FGFR1/2/3* and PDGFRα/β with IC₅₀s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

HY-105028S

Tenidap-d3 CP-66248-D3	COX	Inflammation/Immunology
Tenidap-d3 (CP-66248-d3) is the deuterium labeled Tenidap. Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC₅₀ values of 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties. Tenidap is also a specific SLC26A3 inhibitor.

HY-B0656AS1

Rabeprazole-d3 sodium LY307640-D3 sodium	Proton Pump Apoptosis	Inflammation/Immunology Cancer
Rabeprazole-d3 (LY307640-d3) sodiumis the deuterium labeled Rabeprazole sodium. Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H⁺/K⁺-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC₅₀ of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux.

HY-10582S

Flurbiprofen-d3 dl-Flurbiprofen-D3	COX Apoptosis	Inflammation/Immunology Cancer
Flurbiprofen-d3 (dl-Flurbiprofen-d3) is the deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer.

HY-B0648S

Medroxyprogesterone-d3 17α-Hydroxy-6α-methylprogesterone-D3; U8840-D3	Progesterone Receptor	Endocrinology
Medroxyprogesterone-d3 (17α-Hydroxy-6α-methylprogesterone-d3) is the deuterium labeled Medroxyprogesterone. Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.

HY-B0271S

Pyrazinamide-d3 Pyrazinecarboxamide-D3; Pyrazinoic acid amide-D3	Bacterial Autophagy Antibiotic	Infection
Pyrazinamide-d3 is deuterium labeled Pyrazinamide. Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a prodrug that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

HY-B0105BS

(-)-Ketoconazole-d3 (-)-Ketoconazol-D3; (-)-R 41400-D3	Fungal	Infection Inflammation/Immunology
(-)-Ketoconazole-d3 is deuterium labeled (-)-Ketoconazole. (-)-Ketoconazole ((-)-R 41400) is one of the enantiomer of Ketoconazole. Ketoconazole is a racemic mixture of two enantiomers, levoketoconazole ((2S,4R)-(−)-ketoconazole) and dextroketoconazole ((2R,4S)-(+)-ketoconazole).

HY-W004260S2

Arachidic acid-d3 Icosanoic acid-D3	Endogenous Metabolite	Others
Arachidic acid-d3 (Icosanoic acid-d3) is the deuterium labeled Arachidic acid. Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue.

HY-N0136S

Taxifolin-d3 (+)-Dihydroquercetin-D3; (+)-Taxifolin-D3	Autophagy Tyrosinase	Inflammation/Immunology
Taxifolin-d3 is deuterium labeled Taxifolin. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity.

HY-10394S

Linezolid-d3 PNU-100766-D3	Bacterial Antibiotic	Infection
Linezolid D3 is a deuterium labeled Linezolid (PNU-100766). Linezolid is a synthetic antibiotic that acts by inhibiting the initiation of bacterial protein synthesis.

HY-70002S

Enzalutamide-d3 MDV3100-D3	Androgen Receptor Autophagy	Cancer
Enzalutamide D3 is a deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC₅₀ of 36 nM in LNCaP prostate cells.

HY-101346S

ZD 7288-d3 ICI D7288-D3	HCN Channel	Neurological Disease
ZD 7288-d3 (ICI D7288-d3) is the deuterium labeled ZD7288. ZD7288 (ICI D7288) is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker.

HY-136450S

Triclabendazole sulfoxide-d3 TCBZ-SO-D3	Parasite BCRP	Infection
Triclabendazole sulfoxide-d3 (TCBZ-SO-d3) is the deuterium labeled Triclabendazole sulfoxide. Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP.

HY-N0370S

Bergapten-d3 5-Methoxypsoralen-D3	Cytochrome P450 Autophagy	Cancer
Bergapten-d3 is deuterium labeled Bergapten. Bergapten is a natural anti-inflammatory and anti-tumor agent. Bergapten is inhibitory towards mouse and human CYP isoforms.

HY-10201S

Sorafenib-d3 Bay 43-9006-D3; Donafenib	Raf VEGFR FLT3 Ferroptosis Autophagy Apoptosis	Cancer
Sorafenib-d3 (Bay 43-9006-d3) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC₅₀s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.

HY-W014423S7

L-Histidine-d3 hydrochloride hydrate H-His-OH-D3 hydrochloride hydrate	Endogenous Metabolite	Metabolic Disease
L-Histidine-d3 (H-His-OH-d3) hydrochloride hydrateis the deuterium labeled L-Histidine (hydrochloride hydrate). L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.

HY-A0093S1

Mexiletine-d3 hydrochloride KOE-1173-D3 hydrochloride	Sodium Channel	Cardiovascular Disease
Mexiletine-d3 (hydrochloride) is deuterium labeled Mexiletine (hydrochloride). Mexiletine hydrochloride (KOE-1173 hydrochloride), a Class IB antianhythmic, is a non-selective voltage-gated sodium channel blocker.

HY-14818AS

Laninamivir octanoate-d3 CS-8958-D3	Influenza Virus	Infection
Laninamivir octanoate-d3 (CS-8958-d3) is the deuterium labeled Laninamivir octanoate. Laninamivir octanoate (CS-8958), a prodrug of Laninamivir, is a long-acting neuraminidase (NA) inhibitor with anti-influenza virus activity. Laninamivir octanoate shows anti-influenza activity against Oseltamivir-resistant viruses, and also against the pandemic influenza viruses.

HY-Y1069S

(S)-Malic acid-d3 (S)-Hydroxybutanedioic acid-D3; (S)-E 296-D3	Endogenous Metabolite	Metabolic Disease
(S)-Malic acid-d3 ((S)-Hydroxybutanedioic acid-d3) is the deuterium labeled (S)-Malic acid. (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive.

HY-B0241S

Ipratropium-d3 bromide Sch 1000-D3	mAChR	Inflammation/Immunology Neurological Disease
Ipratropium-d3 bromide (Sch 1000-d3) is the deuterium labeled Ipratropium bromide. Ipratropium bromide (Sch 1000) is a muscarinic receptor antagonist, with binding IC₅₀ values of 2.9 nM, 2 nM, and 1.7 nM for M1, M2, and M3 receptors, respectively. Ipratropium bromide can be used in the research for COPD (chronic obstructive pulmonary disease) and asthma.

HY-B0008S

Sulindac-d3 MK-231-D3	COX Autophagy	Inflammation/Immunology Cancer
Sulindac-d3 is deuterium labeled Sulindac. Sulindac (MK-231) is a non-steroidal antiinflammatory agent, acts as a COX-2 inhibitor, and inhibits overexpression of COX-2.

HY-113139S

1-Methylinosine-d3 N1-Methylinosine-D3	Nucleoside Antimetabolite/Analog Endogenous Metabolite	Metabolic Disease
1-Methylinosine-d3 (N1-Methylinosine-d3) is the deuterium labeled 1-Methylinosine. 1-Methylinosine is a modified nucleotide found at position 37 in tRNA 3' to the anticodon of eukaryotic tRNA.

HY-50910S2

Temsirolimus-d3-1 CCI-779-D3-1	mTOR Autophagy Apoptosis	Cancer
Temsirolimus-d3-1 (CCI-779-d3-1) is the deuterium labeled Temsirolimus. Temsirolimus is an inhibitor of mTOR with an IC₅₀ of 1.76 μM. Temsirolimus activates autophagy and prevents deterioration of cardiac function in animal model.

HY-17360S

Tiotropium-d3 bromide BA679 BR-D3	mAChR	Neurological Disease
Tiotropium-d3 (bromide) (BA679 BR-d3) is the deuterium labeled Tiotropium (Bromide). Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

HY-75958S

Vitamin D4-d3 22-Dihydroergocalciferol-D3	VD/VDR	Metabolic Disease
Vitamin D4-d3 (22-Dihydroergocalciferol-d3) is the deuterium labeled Vitamin D4. Vitamin D4 (22-Dihydroergocalciferol) is a Vitamin D derived from fungi. The precursor of Vitamin D4 is 22,23-dihydroergosterol.

HY-N0294S

Protocatechuic acid-d3 3,4-Dihydroxybenzoic acid-D3	Endogenous Metabolite	Neurological Disease
Protocatechuic acid-d3 (3,4-Dihydroxybenzoic acid-d3) is the deuterium labeled Protocatechuic acid. Protocatechuic acid is a phenolic compound which exhibits neuroprotective effect.

HY-Z0548S

Methyl 3,4-dihydroxybenzoate-d3 Protocatechuic acid methyl ester-D3; Methyl protocatechuate-D3	Keap1-Nrf2 Apoptosis	Cancer Inflammation/Immunology
Methyl 3,4-dihydroxybenzoate-d3 (Protocatechuic acid methyl ester-d3) is the deuterium labeled Methyl 3,4-dihydroxybenzoate. Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester; Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect.

HY-N1181S

Tamarixetin-d3 4'-O-Methyl Quercetin-D3	Endogenous Metabolite	Inflammation/Immunology
Tamarixetin-d3 (4'-O-Methyl Quercetin-d3) is the deuterium labeled Tamarixetin. Tamarixetin (4'-O-Methyl Quercetin) is a natural flavonoid derivative of quercetin, with anti-oxidative and anti-inflammatory effects. Tamarixetin protects against cardiac hypertrophy.

HY-B0113S2

Omeprazole metabolite Omeprazole sulfone (methoxy-d3) Omeprazole sulfone (methoxy-D3); Omeprazole sulphone (methoxy-D3)	Drug Metabolite	Cancer Infection
Omeprazole metabolite Omeprazole sulfone (methoxy-d3) (Omeprazole sulfone (methoxy-d3)) is the deuterium labeled Omeprazole metabolite Omeprazole sulfone. Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor.

HY-B1244S

Dimetridazole-d3 1,2-Dimethyl-5-nitroimidazole-D3	Parasite Antibiotic	Infection
Dimetridazole-d3 (1,2-Dimethyl-5-nitroimidazole-d3) is a deuterium labeled Dimetridazole. Dmetridazole, a nitroimidazole-based antibiotic, combats protozoan infections.

HY-117580S

16α-Hydroxyprednisolone-d3 OH-PRED-D3	Drug Metabolite	Inflammation/Immunology
16α-Hydroxyprednisolone-d3 (OH-PRED-d3) is the deuterium labeled 16α-Hydroxyprednisolone. 16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid budesonide via cytochrome P450 3A (CYP3A) enzymes.

HY-B0270S

Suprofen-d3
PGE synthase Inflammation/Immunology

Suprofen-d3 (TN-762-d3) is the deuterium labeled Suprofen. Suprofen (TN-762) is a non-steroidal anti-inflammatory drug (NSAID).

HY-132549S

Nilotinib-d3	Bcr-Abl Autophagy	Cancer
Nilotinib-d3 (AMN107-d3) is the deuterium labeled Nilotinib. Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.

HY-17506S

Azithromycin-d3	Bacterial Autophagy Antibiotic	Infection Cancer
Azithromycin-d3 (CP 62993-d3) is the deuterium labeled Azithromycin. Azithromycin (CP-62993) is a macrolide antibiotic useful for the treatment of a number of bacterial infections.

HY-32349S

Ercalcidiol-d3 25-hydroxy Vitamin D2-D3	Endogenous Metabolite	Metabolic Disease
Ercalcidiol-d3 (25-hydroxy Vitamin D2-d3) is the deuterium labeled Ercalcidiol. Ercalcidiol is a metabolite of Vitamins D2. Ercalcidiol can be used as an indicator of vitamins D status.

HY-B0161ES

(±)-Duloxetine-d3 hydrochloride (Rac)-Duloxetine-D3 hydrochloride	Serotonin Transporter	Neurological Disease
(±)-Duloxetine-d3 (hydrochloride) is deuterium labeled (±)-Duloxetine (hydrochloride). (±)-Duloxetine ((Rac)-Duloxetine) hydrochloride is the racemate of Duloxetine hydrochloride. Duloxetine hydrochloride, a serotonin-norepinephrine reuptake inhibitor, can be used for diabetic neuropathic pain and fibromyalgia as well as major depressive disorder research.

HY-A0168S

Regadenoson-d3 CVT-3146-D3	Adenosine Receptor	Cardiovascular Disease Cancer
Regadenoson-d3 (CVT-3146-d3) is the deuterium labeled Regadenoson. Regadenoson (CVT-3146) is a potent and selective A2A adenosine receptor agonist, with K_is of 290 and 1120 nM for rat and pig adenosine A2A receptor, respectively. Regadenoson is selective for the adenosine A2A receptor over adenosine A1 and A2B receptors, and shows 13-fold selectivity over the human adenosine A1 receptor. Regadenoson is a vasodilator stress agent has shifted the landscape of vasodilator myocardial perfusion imaging. Regadenoson increases blood-brain barrier (BBB) permeability in rodents.

HY-B0421S1

Mycophenolic acid 13C,D3 Mycophenolate 13C,D3	Fungal Bacterial Endogenous Metabolite Apoptosis Antibiotic	Inflammation/Immunology
Mycophenolic acid 13C,D3 (Mycophenolate 13C,D3) is deuterium labeled Mycophenolic acid 13C. Mycophenolic acid is an an immunosuppresant drug and has potent anti-proliferative activity.

HY-W013549S

6-Aminopenicillanic acid-d3 6-APA-D3	Bacterial	Infection
6-Aminopenicillanic acid-d3 (6-APA-d3) is the deuterium labeled 6-Aminopenicillanic acid. 6-Aminopenicillanic acid (6-APA) is an important precursor for the synthesis of -lactam antibiotics. 6-Aminopenicillanic acid is the main product of Penicillin G (PenG) hydrolyzed by penicillin acylase (PA).

HY-B1451S

Imidapril-d3 hydrochloride	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Imidapril-d3 hydrochloride (TA-6366-d3) is the deuterium labeled Imidapril hydrochloride. Imidapril hydrochloride (TA-6366) is the hydrochloride salt of Imidapril, an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.

HY-B0426AS

Olopatadine-d3 hydrochloride	Histamine Receptor	Inflammation/Immunology Endocrinology
Olopatadine-d3 hydrochloride (ALO4943A-d3) is the deuterium labeled Olopatadine hydrochloride. Olopatadine hydrochloride (ALO4943A) is a histamine blocker used to treat allergic conjunctivitis.

HY-15202S

Binimetinib-13C,d3 MEK162-13C,D3; ARRY-162-13C,D3; ARRY-438162-13C,D3	MEK Autophagy	Cancer
Binimetinib-13C,d3 (MEK162-13C,d3) is the 13C- and deuterium labeled Binimetinib. Binimetinib (MEK162) is an oral and selective MEK1/2 inhibitor. Binimetinib (MEK162) inhibits MEK with an IC₅₀ of 12 nM.

HY-14299S

Indacaterol-d3
Adrenergic Receptor Neurological Disease Endocrinology

Indacaterol-d3 is deuterium labeled Indacaterol.
HY-A0251AS

Cefpodoxime-d3 sodium
Antibiotic

Cefpodoxime-d3 (sodium) is deuterium labeled Cefpodoxime sodium.
HY-B0949AS

Protriptyline-d3

Protriptyline-d3 is deuterium labeled Protriptyline.
HY-B1622S

Cyproheptadine-d3

Cyproheptadine-d3 is deuterium labeled Cyproheptadine.
HY-118126S

Mecoprop-d3

Mecoprop-d3 is deuterium labeled Mecoprop.
HY-113422S1

Tetrahydrocorticosterone-d3

Tetrahydrocorticosterone-d3 is the deuterium labeled Tetrahydrocorticosterone.
HY-B0528S

Octopamine-d3
Endogenous Metabolite

Octopamine-d3 is deuterium labeled Octopamine.
HY-131631S

Desmethylcyclobenzaprine-d3 hydrochloride

Desmethylcyclobenzaprine-d3 (hydrochloride) is deuterium labeled Desmethylcyclobenzaprine (hydrochloride).
HY-Y0600S

Thioanisole-d3

Thioanisole-d3 is deuterium labeled Thioanisole.
HY-B0898S

Ceftiofur-d3 sodium
Bacterial Antibiotic Infection

Ceftiofur-d3 (sodium) is deuterium labeled Ceftiofur (sodium).
HY-B0318S2

Metronidazole-d3
Bacterial Parasite Apoptosis Antibiotic Infection

Metronidazole-d3 is deuterium labeled Metronidazole.
HY-134222AS

Acetylserine-d3
Endogenous Metabolite

Acetylserine-d3 is the deuterium labeled Acetylserine.
HY-W286743S1

CML-d3

CML-d3 is the deuterium labeled CML.
HY-B0444S1

Maprotiline-d3 hydrochloride
Autophagy Neurological Disease

Maprotiline-d3 (hydrochloride) is deuterium labeled Maprotiline (hydrochloride).
HY-121151S

Amethopterin-d3

Amethopterin-d3 is deuterium labeled Amethopterin.
HY-B0531S

Triflusal-d3
COX Inflammation/Immunology

Triflusal-d3 is deuterium labeled Triflusal.
HY-19489S3

(±)-Levomepromazine-d3

(±)-Levomepromazine-d3 is deuterium labeled (±)-Levomepromazine.

HY-17038S2

Agomelatin-d3 S-20098-D3	Melatonin Receptor 5-HT Receptor Endogenous Metabolite	Neurological Disease
Agomelatin-d3 (S-20098-d3) is the deuterium labeled Agomelatine. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with K_is of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine is a selective 5-HT2C receptor antagonist with pK_is of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively.

HY-B0165CS

Pravastatin-d3 sodium salt	HMG-CoA Reductase (HMGCR) Autophagy	Cardiovascular Disease
Pravastatin-d3 (CS-514-d3) sodium salt is the deuterium labeled Pravastatin sodium salt. Pravastatin (CS-514) sodium salt is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC₅₀ of 5.6 μM.

HY-10570S1

Nevirapine-d3	HIV Reverse Transcriptase	Infection Cancer
Nevirapine-d3 (BI-RG 587-d3) is the deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a K_i of 270 μM.

HY-B0272S

Rifampicin-d3	Bacterial Influenza Virus Antibiotic	Infection
Rifampicin-d3 (Rifampin-d3) is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.

HY-18062S

Pyrimethamine-d3	Antifolate Parasite	Infection
Pyrimethamine-d3 (Pirimecidan-d3) is the deuterium labeled Pyrimethamine. Pyrimethamine is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR).

HY-B1716S

L-5-Hydroxytryptophan-d3 L-5-HTP-D3; Oxitriptan-D3	Endogenous Metabolite	Metabolic Disease Neurological Disease
L-5-Hydroxytryptophan-d3 (L-5-HTP-d3) is the deuterium labeled L-5-Hydroxytryptophan. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist. L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia.

HY-143962S

Halobetasol-d3

Halobetasol-d3 是 Halobetasol氘代物。
HY-143937S

Carbidopa-d3

Carbidopa-d3 是 Carbidopa氘代物。
HY-143861S

Orphenadrine-d3

Orphenadrine-d3 是 Orphenadrine氘代物。
HY-143999S

Norgestimate-d3

Norgestimate-d3 是 Norgestimate氘代物。
HY-143942S

Cefditoren-d3

Cefditoren-d3 是 Cefditoren氘代物。

HY-B1059S

Levosulpiride-d3	Dopamine Receptor	Neurological Disease
Levosulpiride-d3 (RV-12309-d3) is the deuterium labeled Levosulpiride. Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiride, which is a D2 receptor a antagonist, an atypical antipsychotic drug of the benzamide class.

HY-17355BS

Dexpramipexole-d3 dihydrochloride	Dopamine Receptor	Neurological Disease
Dexpramipexole-d3 ((R)-Pramipexole-d3) dihydrochloride is the deuterium labeled Dexpramipexole. Dexpramipexole((R)-Pramipexole), also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist.

HY-143792

HTT-D3	P-glycoprotein	Neurological Disease
HTT-D3 is a potent and orally active huntingtin (HTT) splicing modulator. HTT-D3 acts by promoting the inclusion of a pseudoexon containing a premature termination codon (stop-codon psiExon), leading to HTT mRNA degradation and reduction of HTT levels. HTT-D3 reduces p-glycoprotein (P-gp) efflux, and can be uesd for Huntington's disease research.

HY-90001S1

Ritonavir-13C,d3 ABT 538-13C,D3; RTV-13C,D3	HIV Protease HIV SARS-CoV Apoptosis	Infection
Ritonavir-13C,d3 (ABT 538-13C,d3) is the 13C- and deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a *SARS-CoV 3CL* pro inhibitor with an IC₅₀** of 1.61 μM.

HY-132348S

Granisetron-d3	5-HT Receptor	Neurological Disease
Granisetron-d3 (BRL 43694-d3) is the deuterium labeled Granisetron. Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

HY-B0157AS

Ketotifen-d3 fumarate	Histamine Receptor	Inflammation/Immunology Endocrinology
Ketotifen-d3 (HC 20511-d3) fumarate is the deuterium labeled Ketotifen fumarate. Ketotifen (HC 20511) fumarate is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer, which is used to prevent asthma attacks.

HY-W015339S1

Octanoate-d3 sodium

Octanoate-d3 sodium is the deuterium labeled Octanoate.

HY-113346S

Tetrahydrodeoxycorticosterone-d3 Tetrahydro-11-deoxycorticosterone-D3	GABA Receptor Endogenous Metabolite
Tetrahydrodeoxycorticosterone-d3 is the deuterium labeled Tetrahydrodeoxycorticosterone. Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABAA receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties.

HY-B0002BS2

Ondansetron-13C,d3
GR 38032-13C,D3; SN 307-13C,D3
5-HT Receptor Neurological Disease

Ondansetron-13C,d3 is the 13C- and deuterium labeled.

HY-B0002S

Ondansetron-d3 hydrochloride	5-HT Receptor	Neurological Disease
Ondansetron-d3 (GR 38032-d3) hydrochloride) is the deuterium labeled Ondansetron hydrochloride. Ondansetron hydrochloride (GR 38032 hydrochloride) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.

HY-N0229S12

L-Alanine-d3 L-2-Aminopropionic acid-D3	Endogenous Metabolite	Metabolic Disease Neurological Disease
L-Alanine-d3 (L-2-Aminopropionic acid-d3) is the deuterium labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.

HY-N6703S

ar-Turmerone-d3 (+)-ar-Turmerone-D3	Apoptosis	Cancer Inflammation/Immunology
ar-Turmerone-d3 ((+)-ar-Turmerone-d3) is the deuterium labeled ar-Turmerone. ar-Turmerone ((+)-ar-Turmerone) is a major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities. ar-Turmerone activates apoptotic protein in human lymphoma U937 cells. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation and constitutes a promising therapeutic agent for various neurologic disorders.

HY-A0023AS1

Alogliptin-d3 SYR-322-D3 free base	Dipeptidyl Peptidase Ferroptosis	Metabolic Disease Inflammation/Immunology Cardiovascular Disease
Alogliptin-d3 (SYR-322-d3 (free base)) is the deuterium labeled Alogliptin. Alogliptin (SYR-322 free base) is a potent, selective and orally active inhibitor of DPP-4 with an IC₅₀ of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin can be used for the research of type 2 diabetes.

HY-16293S

Lurbinectedin-d3 PM01183-D3	DNA Alkylator/Crosslinker DNA/RNA Synthesis	Cancer
Lurbinectedin D3 is deuterium labeled Lurbinectedin. Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC₅₀ values of 1.25 and 1.16 nM, respectively.

HY-B0225AS

Methyldopa-d3 hydrochloride L-(-)-α-Methyldopa-D3 hydrochloride; MK-351-D3 hydrochloride	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa-d3 (hydrochloride) is deuterium labeled Methyldopa (hydrochloride). Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrochloride is a prodrug and is metabolized (α-Methylepinephrine) in the central nervous system.

HY-113371S

2-Methylcitric acid-d3 Methylcitric acid-D3	Endogenous Metabolite	Metabolic Disease
2-Methylcitric acid-d3 (Methylcitric acid-d3) is the deuterium labeled 2-Methylcitric acid. 2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate.

HY-B0330S2

Levofloxacin-13C,d3
(-)-Ofloxacin-13C,D3
Bacterial Antibiotic Infection

Levofloxacin-13C,d3 is the 13C- and deuterium labeled.
HY-121272AS1

Difloxacin-d3 hydrochloride
Others Others

Difloxacin-d3 (hydrochloride) is the deuterium labeled Difloxacin (hydrochloride).

HY-10889S

Preladenant-d3	Adenosine Receptor	Neurological Disease
Preladenant-d3 (SCH-420814-d3) is the deuterium labeled Preladenant. Preladenant is a potent and competitive antagonist of the human adenosine A2A receptor with a K_i of 1.1 nM and has over 1000-fold selectivity over other adenosine receptors.

HY-40354AS

Tofacitinib-d3 citrate Tasocitinib-D3 citrate; CP-690550-D3 citrate	JAK Apoptosis Bacterial Fungal Influenza Virus	Cancer Infection Inflammation/Immunology
Tofacitinib-d3 (citrate) is deuterium labeled Tofacitinib (citrate). Tofacitinib citrate is an orally available JAK1/2/3 inhibitor with IC50s of 1, 20, and 112 nM, respectively. Tofacitinib citrate has antibacterial, antifungal and antiviral activities.

HY-N0650S9

L-Serine-15N,d3 (-)-Serine-15N,D3; (S)-Serine-15N,D3	Endogenous Metabolite	Cancer
L-Serine-15N,d3 ((-)-Serine-15N,d3) is the deuterium and 15N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-15287S

Nelfinavir-d3	HIV Protease HIV	Infection Cancer
Nelfinavir-d3 (AG1341-d3) is the deuterium labeled Nelfinavir. Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (K_i=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent.

HY-13904S

Flumatinib-d3 HHGV678-D3	Bcr-Abl c-Kit PDGFR	Cancer
Flumatinib-d3 is deuterium labeled Flumatinib. Flumatinib (HHGV678) is an orally available, selective inhibitor of Bcr-Abl. Flumatinib inhibits c-Abl, PDGFRβ and c-Kit with IC50s of 1.2 nM, 307.6 nM and 665.5 nM, respectively.

HY-90009CS

ent-Tadalafil-d3 ent-IC-351-D3	Phosphodiesterase (PDE)	Cancer
ent-Tadalafil-d3 (ent-IC-351-d3) is the deuterium labeled ent-Tadalafil. ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS). compound (6R,12aS) is a potent PDE5 inhibitor with an IC₅₀ of 0.090 μM, while ent-Tadalafil is inactive at concentrations up to 10 µM.

HY-B0782S

Acetazolamide-d3
Carbonic Anhydrase Cardiovascular Disease

Acetazolamide D3 is deuterium labeled Acetazolamide, which is a potent carbonic anhydrase (CA) inhibitor.

HY-113432S

Nudifloramide-d3	Endogenous Metabolite PARP	Metabolic Disease
Nudifloramide-d3 (2PY-d3) is the deuterium labeled Nudifloramide. Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro.

HY-W019151S

Meconin-d3
Endogenous Metabolite Metabolic Disease

Meconin-d3 is the deuterium labeled Meconine. Meconine is an endogenous metabolite.

HY-113294S1

*3-Hydroxykynurenine-d3* 3-Hydroxy-DL-kynurenine-D3	Endogenous Metabolite Apoptosis	Neurological Disease
3-Hydroxykynurenine-d3 (3-Hydroxy-DL-kynurenine-d3) is the deuterium labeled 3-Hydroxykynurenine. 3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis[1].

HY-14779S2

Riociguat-13C,d3 BAY 632521-13C,D3	Guanylate Cyclase	Cardiovascular Disease
Riociguat-13C,d3 (BAY 632521-13C,d3) is the 13C- and deuterium labeled Riociguat. Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.

HY-A0039S

Eletriptan-d3	5-HT Receptor	Neurological Disease
Eletriptan-d3 (Eletriptan-d3 HBr) is the deuterium labeled Eletriptan hydrobromide. Eletriptan hydrobromide is a selective 5-HT1B and 5-HT1D receptor agonist with K_i of 0.92 nM and 3.14 nM, respectively.

HY-14252S

Milrinone-d3
Phosphodiesterase (PDE) Cardiovascular Disease

Milrinone-d3 is deuterium labeled Milrinone. Milrinone is a PDE3 inhibitor, and also an inotrope and vasodilator.

HY-121162S

Mesembrine-d3	5-HT Receptor Phosphodiesterase (PDE)	Neurological Disease
Mesembrine-d3 ((+)-Mesembrine-d3) is the deuterium labeled Mesembrine. Mesembrine ((+)-Mesembrine) a main alkaloid that features an aryloctahydroindole skeleton. Mesembrine is a 5-HT transporter inhibitor with a K_i of 1.4 nM. Mesembrine also inhibits phosphodiesterase 4B (PDE4B) with an IC₅₀ of 7.8 μM.

HY-B0612DS

(R)-Lercanidipine-d3 hydrochloride	Calcium Channel	Cardiovascular Disease
(R)-lercanidipine D3 (hydrochloride) is a deuterium labeled (R)-Lercanidipine hydrochloride. (R)-Lercanidipine D3 (hydrochloride), the R-enantiomer of Lercanidipine, is a calcium channel blocker.

HY-17413S1

Zidovudine-13C,d3 Azidothymidine-13C,D3; AZT-13C,D3; ZDV-13C,D3	HIV CRISPR/Cas9	Infection
Zidovudine-13C,d3 is the 13C- and deuterium labeled. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency.

HY-113466S

4-Hydroxynonenal-d3 4-HNE-D3	Aldehyde Dehydrogenase (ALDH) Endogenous Metabolite	Cancer Neurological Disease Cardiovascular Disease
4-Hydroxynonenal-d3 (4-HNE-d3) is the deuterium labeled 4-Hydroxynonenal. 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria.

HY-B0233S

Isradipine-d3	Calcium Channel Autophagy	Neurological Disease Cardiovascular Disease
Isradipine-d3 (PN 200-110-d3) is the deuterium labeled Isradipine. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease.

HY-10564S

Sarpogrelate-d3 hydrochloride MCI-9042-D3	5-HT Receptor	Cardiovascular Disease
Sarpogrelate-d3 hydrochloride (MCI-9042-d3) is the deuterium labeled Sarpogrelate hydrochloride. Sarpogrelate hydrochloride (MCI-9042) is a selective 5-HT₂R antagonist, with pK_is of 8.52, 6.57, and 7.43 for 5-HT_2A, 5-HT_2B, and 5-HT_2C receptors, respectively. Sarpogrelate hydrochloride displays selectivity over 5-HT₁, 5-HT₃, 5-HT₄, α₁-, α₂- and β-adrenoreceptor, histamine H₁, H₂ and muscarinic M₃ receptors. Sarpogrelate hydrochloride can be used for the research of vascular disease associated with thrombosis.

HY-B0375S

Argatroban-d3
Thrombin Cardiovascular Disease

Argatroban-d3 is the deuterium labeled Argatroban. Argatroban (MD-805) is a direct, selective thrombin inhibitor.

HY-B0501S

Danofloxacin-d3 mesylate	Bacterial Antibiotic	Infection
Danofloxacin-d3 mesylate is the deuterium labeled Danofloxacin mesylate. Danofloxacin mesylate (CP 76136-27) is a fluoroquinolone antibacterial for veterinary use.

HY-B1164S

Bromopride-d3	Dopamine Receptor	Neurological Disease
Bromopride-d3 is the deuterium labeled Bromopride. Bromopride is a dopamine antagonist with prokinetic properties, widely used as an antiemetic.

HY-113468AS

*3-O-Methyldopa-d3* 3-Methoxy-L-tyrosine-D3; 3-O-Methyl-L-DOPA-D3	Dopamine Receptor Endogenous Metabolite	Neurological Disease
3-O-Methyldopa D3 (3-Methoxy-L-tyrosine D3) is deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine.

HY-101064S2

Fmoc-leucine-d3 N-FMOC-leucine-D3; NPC 15199-D3; NSC 334290-D3	PPAR
Fmoc-leucine-d3 is the deuterium labeled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity.

HY-B1751S

Quinidine-d3	Parasite	Infection Cardiovascular Disease
Quinidine-d3 is the deuterium labeled Quinidine. Quinidine is an antiarrhythmic agent for the treatment of abnormal heart rhythms and also malaria.

HY-B0823S

Acetamiprid-d3
nAChR Neurological Disease

Acetamiprid-d3 is the deuterium labeled Acetamiprid. Acetamiprid is a neonicotinoid insecticide. Acetamiprid is a nAChR agonist.

HY-13238S1

Dolutegravir-d3 S/GSK1349572-D3	HIV Integrase HIV	Infection
Dolutegravir-d3 (S/GSK1349572-d3) is the deuterium labeled Dolutegravir. Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC₅₀ of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC₅₀ of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC₅₀=3.6-5.8 nM).

HY-B0740S1

Cyclobenzaprine-13C,d3 hydrochloride
MK130-13C,D3 hydrochloride
5-HT Receptor Neurological Disease

Cyclobenzaprine-13C,d3 (hydrochloride) is the 13C- and deuterium labeled.
HY-B0192S1

Alfuzosin-13C,d3
SL 77499-13C,D3
Adrenergic Receptor Endocrinology

Alfuzosin-13C,d3 is the 13C- and deuterium labeled.
HY-18252S

Avanafil-13C,d3
TA1790-13C,D3
Phosphodiesterase (PDE) Cardiovascular Disease

Avanafil-13C,d3 is the 13C- and deuterium labeled.
HY-B0621S1

Triclabendazole-13C,d3
CGA89317-13C,D3
Microtubule/Tubulin Parasite Infection

Triclabendazole-13C,d3 is the 13C- and deuterium labeled.

HY-N0181AS

Lumisterol-d3 9β,10α-Ergosterol-D3	Endogenous Metabolite	Metabolic Disease
Lumisterol-d3 (9β,10α-Ergosterol-d3) is the deuterium labeled Lumisterol. Lumisterol (9β,10α-Ergosterol), a steroid compound, is the (9β,10α)-stereoisomer of Ergosterol. Lumisterol is a photoprotective agent against UVB-induced DNA damage and anti-proliferative activities.

HY-B0113S1

Omeprazole-d3-1 H 16868-D3-1	Proton Pump Autophagy Bacterial Phospholipase	Cancer Infection Metabolic Disease
Omeprazole-d3-1 (H 16868-d3-1) is the deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a K_i of 2 to 6 μM. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria.Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).

HY-14519S

Methotrexate-d3	Antifolate DNA/RNA Synthesis ADC Cytotoxin Apoptosis	Cancer Inflammation/Immunology
Methotrexate-d3 (Amethopterin-d3) is the deuterium labeled Methotrexate. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia).

HY-13442AS

Eribulin-d3 mesylate	Microtubule/Tubulin Apoptosis	Cancer
Eribulin-d3 mesylate is a deuterium labeled Eribulin mesylate. Eribulin mesylate is a microtubule targeting agent that is used for the research of cancer.

HY-17507S1

Pantoprazole-d3 BY1023-D3; SKF96022-D3	Proton Pump Autophagy Apoptosis	Cancer Inflammation/Immunology
Pantoprazole-d3 is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI). Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142).

HY-50895S2

Gefitinib-d3	EGFR Autophagy	Cancer
Gefitinib-d3 (ZD1839-d3) is the deuterium labeled Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC₅₀ of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC₅₀ of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity.

HY-B0763S

Ibudilast-d3	Phosphodiesterase (PDE)	Inflammation/Immunology Cancer
Ibudilast-d3 (KC-404-d3) is the deuterium labeled Ibudilast. Ibudilast (KC-404) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia.

HY-B1786S

Sulindac sulfide-d3 cis-Sulindac sulfide-D3	γ-secretase	Neurological Disease
Sulindac sulfide-d3 is deuterium labeled Sulindac sulfide. Sulindac sulfide is a noncompetitive γ-secretase inhibitor, with an IC50 of 20.2 μM for γ42-secretase activity.

HY-B0762S

Acetyl-L-carnitine-d3 hydrochloride O-Acetyl-L-carnitine-D3 hydrochloride	Endogenous Metabolite	Neurological Disease
Acetyl-L-carnitine-d3 (O-Acetyl-L-carnitine-d3) hydrochloride is the deuterium labeled Acetyl-L-carnitine hydrochloride. Acetyl-L-carnitine hydrochloride is a blood-brain permeable acetyl ester of the amino acid L-carnitine found in the body. Acetyl-L-carnitine hydrochloride is often used as a dietary supplement, and exibits anti-stress-related psychiatric disorders.

HY-113468AS1

3-O-Methyldopa-d3 hydrate 3-Methoxy-L-tyrosine-D3 hydrate; 3-O-Methyl-L-DOPA-D3 hydrate	Dopamine Receptor Endogenous Metabolite	Neurological Disease
3-O-Methyldopa D3 (3-Methoxy-L-tyrosine D3) hydrate is the deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine.

HY-15285

Doxercalciferol-d3	VD/VDR	Metabolic Disease
Doxercalciferol-D3 is the deuterated form of Doxercalciferol, which is a Vitamin D2 analog that acts as a vitamin D receptor activator (VDRA).

HY-107337S

Delapril-d3 hydrochloride	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Delapril-d3 hydrochloride is the deuterium labeled Delapril hydrochloride. Delapril hydrochloride is an angiotensin-converting enzyme (ACE) inhibitor for the treatment of cardiovascular diseases.

HY-N0193S

Artesunate-d3
STAT Ferroptosis Parasite Virus Protease Cancer

Artesunate-d3 is the deuterium labeled Artesunate. Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).
HY-B2067S

Cymoxanil-d3
Fungal Infection

Cymoxanil-d3 is the deuterium labeled Cymoxanil. Cymoxanil is a fungicide against plant diseases caused by fungi belonging to the Perenosporales.

HY-19347S

WDR5-0103-d3 WD-Repeat Protein 5-0103-D3	Histone Methyltransferase	Cancer
WDR5-0103-d3 (WD-Repeat Protein 5-0103-d3) is the deuterium labeled WDR5-0103. WDR5-0103 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist with K_d of 450 nM.

HY-17364S

Temozolomide-d3	DNA Alkylator/Crosslinker Autophagy Apoptosis	Cancer
Temozolomide-d3 (NSC 362856-d3) is the deuterium labeled Temozolomide. Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects.

HY-B0683S

Limaprost-d3	PGE synthase	Inflammation/Immunology Cardiovascular Disease
Limaprost-d3 (17α,20-dimethyl-δ2-PGE1-d3) is the deuterium labeled Limaprost. Limaprost (OP1206) is a PGE1 analogue and a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost pain relief, has antianginal effects, and can be used for ischaemic symptoms research.

HY-13704S

SN-38-d3 NK012-D3	Topoisomerase ADC Cytotoxin Autophagy	Cancer
SN-38-d3 is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC₅₀s of 0.077 and 1.3 μM, respectively.

HY-15330

VD2-d3
VD/VDR Metabolic Disease

VD2-D3 is a deuterated form of vitamin D.

HY-B0162AS1

Ivabradine-d3 hydrochloride	Adrenergic Receptor	Endocrinology
Ivabradine D3 Hydrochloride is the deuterium labeled Ivabradine hydrochloride. Ivabradine hydrochloride is a new I_f inhibitor with IC₅₀ of 2.9 μM, and used as a pure heart rate lowering agent.

HY-B0797S

Etretinate-d3	Apoptosis	Others
Etretinate-d3 is the deuterium labeled Etretinate. Etretinate (Ro 10-9359) is a second-generation retinoid that has the potential for severe psoriasis research.

HY-W010388AS

Creatine-d3 hydrate	Endogenous Metabolite	Metabolic Disease
Creatine D3 hydrate is a deuterium labeled Creatine hydrate. Creatine hydrate is pivotal in energy metabolism of muscle and brain cells, both in physiological and in pathological conditions.

HY-123672S

Lovastatin-d3 hydroxy acid sodium	HMG-CoA Reductase (HMGCR)	Metabolic Disease
Lovastatin-d3 hydroxy acid (Mevinolinic acid-d3) sodium is the deuterium labeled Lovastatin hydroxy acid sodium. Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a K_i of 0.6 nM.

HY-N0707S

(S)-Indoximod-d3 1-Methyl-L-tryptophan-D3; (S)-NLG-8189-D3	Indoleamine 2,3-Dioxygenase (IDO)
(S)-Indoximod-d3 is the deuterium labeled (S)-Indoximod. (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for the research of cancer.

HY-B1193S

Terfenadine-d3	Potassium Channel Histamine Receptor Na+/Ca2+ Exchanger Caspase Apoptosis	Cancer Inflammation/Immunology Endocrinology
Terfenadine-d3 ((±)-Terfenadine-d3) is the deuterium labeled Terfenadine. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC₅₀ of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca²⁺ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.

HY-15605S

Encorafenib-13C,d3 LGX818-13C,D3	Raf	Cancer
Encorafenib-13C,d3 (LGX818-13C,d3) is the 13C- and deuterium labeled Encorafenib. Encorafenib (LGX818) is a highly potent BRAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing BRAF^V600E (EC₅₀=4 nM).

HY-14656S

Diltiazem-d3 hydrochloride	Calcium Channel	Cardiovascular Disease
Diltiazem-d3 hydrochloride is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca²⁺ influx inhibitor (slow channel blocker or calcium antagonist).

HY-B0223S

Albendazole-d3	Parasite	Infection
Albendazole-d3 is the deuterium labeled Albendazole, which is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.

HY-B0192AS

Alfuzosin-d3 hydrochloride	Adrenergic Receptor	Endocrinology
Alfuzosin-d3 hydrochloride is the deuterium labeled Alfuzosin hydrochloride. Alfuzosin hydrochloride is an α1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH).

HY-B0412S2

Estriol-d3	Estrogen Receptor/ERR Endogenous Metabolite	Cancer
Estriol-d3 is the deuterium labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.

HY-B0426AS1

(Z)-Olopatadine-d3 hydrochloride	Histamine Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
(Z)-Olopatadine-d3 (hydrochloride) is deuterium labeled Olopatadine (hydrochloride).

HY-17386S

Rosiglitazone-d3	PPAR TRP Channel Autophagy Ferroptosis	Cancer Metabolic Disease Inflammation/Immunology Neurological Disease
Rosiglitazone-d3 (BRL 49653-d3) is the deuterium labeled Rosiglitazone. Rosiglitazone (BRL 49653) is a selective, orally active PPARγ agonist with EC₅₀s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively. Rosiglitazone binds to PPARγ with a K_d of approximately 40 nM. Rosiglitazone is also an activator of TRPC5 (EC₅₀=~30 μM) and an inhibitor of *TRPM3*.

HY-76251S1

(rac)-Etodolac-d3	COX	Inflammation/Immunology Cancer
(Rac)-Etodolac-d3 ((Rac)-AY-24236-d3) is a labelled racemic Etodolac. Etodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC₅₀=53.5 nM)

HY-10805S

Almorexant-13C,d3 ACT 078573-13C,D3	Orexin Receptor (OX Receptor)	Neurological Disease Endocrinology
Almorexant-13C,d3 (ACT 078573-13C,d3) is the 13C- and deuterium labeled Almorexant. Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with K_i values of 1.3 and 0.17 nM, respectively.

HY-B1596S

Ceftizoxime-d3	Bacterial Antibiotic	Infection
Ceftizoxime-d3 is the deuterium labeled Ceftizoxime. Ceftizoxime is a bacterial inhibitor which acts by interfering with bacterial cell wall synthesis and inhibiting cross-linking of the peptidoglycan.

HY-B0716S1

Urapidil-d3	5-HT Receptor Adrenergic Receptor	Neurological Disease Endocrinology
Urapidil-d3 is the deuterium labeled Urapidil. Urapidil is an α1 adrenoreceptor antagonist and a 5-HT_1A receptor agonist.

HY-B1184S

Mephenytoin-d3
Cytochrome P450 Neurological Disease

(Rac)-Mephenytoin-d3 is a labelled racemic Mephenytoin. Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate.

HY-N0337S

Eugenol-d3	Bacterial Parasite Reactive Oxygen Species Apoptosis Ferroptosis	Infection Inflammation/Immunology Cancer
Eugenol-d3 is the deuterium labeled Eugenol. Eugenol is an essential oil found in cloves with antibacterial, anthelmintic and antioxidant activity. Eugenol is shown to inhibit lipid peroxidation.

HY-15398S1

Vitamin D3-13C	VD/VDR Endogenous Metabolite	Cancer Metabolic Disease
Vitamin D3-13C is the 13C-labeled Vitamin D3. Vitamin D3 (Cholecalciferol; Colecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.

HY-121809S

DL-Methyldopa-d3

DL-Methyldopa-d3 is deuterium labeled DL-Methyldopa.
HY-W010807S

Hexadecyl palmitate-d3

Hexadecyl palmitate-d3 is the deuterium labeled Hexadecyl palmitate.
HY-112009S

Methiocarb sulfoxide-d3

Methiocarb sulfoxide-d3 is deuterium labeled Methiocarb Sulfoxide.
HY-125370S

Phenylephrine glucuronide-d3

Phenylephrine glucuronide-d3 is deuterium labeled Phenylephrine glucuronide.
HY-B0714S

Dexketoprofen-d3 (trometamol)

Dexketoprofen-d3 (trometamol) is deuterium labeled Dexketoprofen trometamol.
HY-W010209S2

DL-Histidine-d3

DL-Histidine-d3 is the deuterium labeled DL-Histidine.
HY-B1787S

Sulindac sulfone-d3

Sulindac sulfone-d3 is deuterium labeled Sulindac sulfone.

HY-B1583S

(Z)-Capsaicin-d3	TRP Channel HSV	Neurological Disease
(Z)-Capsaicin-d3 (Zucapsaicin-d3) is the deuterium labeled (Z)-Capsaicin. (Z)-Capsaicin is the cis isomer of capsaicin, acts as an orally active TRPV1 agonist, and is used in the research of neuropathic pain.

HY-17453S

Salmeterol-d3 xinafoate GR 33343X-D3 xinafoate	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Salmeterol-d3 (GR 33343X-d3) xinafoate is the deuterium labeled Salmeterol xinafoate. Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively.

HY-N7057S1

Nonanoic acid-d3 Pelargonic acid-D3	Bacterial
Nonanoic acid-d3 is the deuterium labeled Nonanoic acid. Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2.

HY-N0328S

Mangostin-d3	Reactive Oxygen Species Apoptosis Bacterial Fungal Virus Protease	Cancer
alpha-Mangostin-d3 (α-Mangostin-d3) is the deuterium labeled alpha-Mangostin. alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a K_i of 2.85 μM.

HY-15398S

Vitamin D3-D7	VD/VDR Endogenous Metabolite	Cancer Metabolic Disease
Vitamin D3-D7 (Cholecalciferol-D7) is the deuterium labeled Vitamin D3. Vitamin D3 (Cholecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.

HY-B0075S1

Melatonin-d3 N-Acetyl-5-methoxytryptamine-D3	Melatonin Receptor Autophagy Mitophagy Endogenous Metabolite Apoptosis	Cancer Inflammation/Immunology Neurological Disease
Melatonin-d3 (N-Acetyl-5-methoxytryptamine-d3) is the deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation. Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress.

HY-B0457S2

Clomipramine-13C,d3 hydrochloride Chlorimipramine-13C,D3 hydrochloride; G-3458613C,D3 hydrochloride; NSC-169865-13C,D3 hydrochloride	Serotonin Transporter	Neurological Disease
Clomipramine-13C,d3 (hydrochloride) is the 13C- and deuterium labeled. Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD).

HY-121046S

Flunixin-d3	COX	Inflammation/Immunology
Flunixin-d3 is the deuterium labeled Flunixin. Flunixin Meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity.

HY-B0726S

Pilocarpine-d3 hydrochloride	mAChR	Neurological Disease
Pilocarpine-d3 (hydrochloride) is deuterium labeled Pilocarpine (Hydrochloride). Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-14171S1

Bexarotene-d3	RAR/RXR Autophagy	Cancer
Bexarotene-d3 (LGD1069-d3) is the deuterium labeled Bexarotene. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM). Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-144163S

Descarbon Sildenafil-d3

Descarbon Sildenafil-d3 是 Descarbon Sildenafil氘代物。
HY-143911S

Acetaminophen glucuronide-d3

Acetaminophen glucuronide-d3 是 Acetaminophen glucuronide氘代物。
HY-144161S

(Rac)-Ramosetron-d3 hydrochloride

(Rac)-Ramosetron-d3 (hydrochloride) 是 (Rac)-Ramosetron氘代物。
HY-143916S

AMX208-d3

AMX208-d3 是 AMX208氘代物。

HY-B0568S

Deferiprone-d3	HCV Ferroptosis	Cardiovascular Disease Cancer
Deferiprone-d3 is the deuterium labeled Deferiprone. Deferiprone is the only orally active iron-chelating drug to be used therapeutically in conditions of transfusional iron overload.

HY-B0946S1

Sulfamonomethoxine-d3	Bacterial Antibiotic	Infection
Sulfamonomethoxine-d3 is the deuterium labeled Sulfamonomethoxine. Sulfamonomethoxine is a long acting sulfonamide antibacterial agent, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate.

HY-12848S

SAG-d3
Smo Cancer

SAG-d3 is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM).

HY-B0830S

Isoprocarb-d3	AChE	Neurological Disease
Isoprocarb-d3 is deuterium labeled Isoprocarb. Isoprocarb is carbamate insecticide that widely used to control rice paddy lice and leafhopper. Isoprocarb is also an AChE inhibitor.

HY-17583S

Griseofulvin-d3	Fungal Apoptosis Antibiotic Endogenous Metabolite	Infection Cancer
Griseofulvin-d3 is the deuterium labeled Griseofulvin. Griseofulvin (Gris-PEG) is a spirocyclic fungal natural product used in treatment of fungal dermatophytes; Antifungal drug.

HY-N0297S

Sinensetin-d3	PGE synthase TNF Receptor	Others
Sinensetin-d3 is the deuterium labeled Sinensetin. Sinensetin is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.

HY-B1119S

Triclosan-d3	Bacterial Fungal Autophagy Antibiotic	Infection Cancer
Triclosan D3 is the deuterium labeled Triclosan. Triclosan is an antibacterial and antifungal agent found in consumer products, including soaps, detergents, toys, and surgical cleaning treatments.

HY-N0125S

Diosmetin-d3	Cytochrome P450	Cancer
Diosmetin-d3 is the deuterium labeled Diosmetin. Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC₅₀ of 40 μM in HepG2 cell.

HY-113280S

Pyridoxol 5'-phosphate-d3
Endogenous Metabolite

Pyridoxol 5'-phosphate-d3 is deuterium labeled Pyridoxine 5'-phosphate.
HY-N0830BS2

Palmitic acid-d3 sodium

Palmitic acid-d3 sodium is the deuterium labeled Palmitic acid.

HY-14818S

Laninamivir-d3	Influenza Virus	Infection
Laninamivir-d3 (R 125489-d3) is the deuterium labeled Laninamivir. Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC₅₀s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively.

HY-B0471S1

Phenylephrine-2,4,6-d3 hydrochloride (R)-(-)-Phenylephrine-2,4,6-D3 hydrochloride; L-Phenylephrine-2,4,6-D3 hydrochloride	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Phenylephrine-2,4,6-d3 ((R)-(-)-Phenylephrine-2,4,6-d3) hydrochloride is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α₁-adrenoceptor agonist with pK_is of 5.86, 4.87 and 4.70 for α_1D, α_1B and α_1A receptors respectively.

HY-N7036S

Rhamnetin-d3	Phospholipase	Inflammation/Immunology
Rhamnetin-d3 is the deuterium labeled Rhamnetin. Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2, with antioxidant and anti-inflammatory activity.

HY-B1110S

Nomifensine-d3 maleate	Dopamine Receptor	Neurological Disease
Nomifensine-d3 maleate is the deuterium labeled Nomifensine maleate. Nomifensine is a norepinephrine-dopamine reuptake inhibitor, increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters.

HY-A0273S

Propyphenazone-d3	COX	Inflammation/Immunology
Propyphenazone-d3 is the deuterium labeled Propyphenazone. Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.

HY-143952S

9-Dihydroestradiol-d3

9-Dihydroestradiol-d3 是 9-Dihydroestradiol氘代物。

HY-121272AS

Difloxacin-d3 hydrochloride trihydrate	Bacterial Antibiotic	Infection Inflammation/Immunology
Difloxacin D3 hydrochloride trihydrate is a deuterium labeled Difloxacin. Difloxacin is an antimicrobial agent.

HY-A0021S

Palonosetron-d3 hydrochloride	5-HT Receptor	Cardiovascular Disease
Palonosetron-d3 hydrochloride is the deuterium labeled Palonosetron hydrochloride. Palonosetron hydrochloride is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).

HY-124584S

Minnelide-d3	Apoptosis	Cancer
Minnelide-d3 is the deuterium labeled Minnelide. Minnelide is a prodrug of triptolide that shows potent antitumor activity in a number of tumor types, particularly in pancreatic cancer. Minnelide promotes apoptosis.

HY-B0835S

Fenobucarb-d3	Apoptosis	Neurological Disease
Fenobucarb-d3 is the deuterium labeled Fenobucarb. Fenobucarb is a carbamate insecticide. Fenobucarb induces zebrafish developmental neurotoxicity through pathways involved in inflammation, oxidative stress, degeneration and apoptosis.

HY-B0561S2

Spironolactone-d3-1 SC9420-D3-1	Mineralocorticoid Receptor Androgen Receptor Autophagy	Metabolic Disease Cancer
Spironolactone-d3-1 is deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes.

HY-113328S

Aminoadipic acid-d3	Endogenous Metabolite	Others
Aminoadipic acid-d3 is the deuterium labeled Aminoadipic acid. Aminoadipic acid is an intermediate in the metabolism of lysine and saccharopine.

HY-14855S

Tedizolid-13C,d3 TR 700-13C,D3; Torezolid-13C,D3; DA-7157-13C,D3	Bacterial Antibiotic	Infection
Tedizolid-13C,d3 is the 13C- and deuterium labeled. Tedizolid (TR 700; Torezolid; DA-7157) is a novel oxazolidinone, acting through inhibition of bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA) of the 50S subunit of the ribosome.

HY-10241S

Simeprevir-13C,d3 TMC435-13C,D3	HCV HCV Protease SARS-CoV	Infection
Simeprevir-13C,d3 (TMC435-13C,d3) is the 13C- and deuterium labeled Simeprevir. Simeprevir (TMC435) is an oral and potent HCV NS3/4A protease inhibitor with a K_i of 0.36 nM. Simeprevir inhibits HCV replication with an EC₅₀ of 7.8 nM. Simeprevir inhibits SARS-CoV-2 3CL pro activity.

HY-B1340S

Carbadox-d3	Bacterial Antibiotic Endogenous Metabolite	Infection
Carbadox-d3 is the deuterium labeled Carbadox. Carbadox is a quinoxaline-di-N-oxide antibiotic compound which is widely fed to nursery-age pigs to control enteric diseases and improve feed efficiency.

HY-B1279AS

Metamizole-d3 sodium	COX	Inflammation/Immunology Neurological Disease
Metamizole-d3 sodium is the deuterium labeled Metamizole sodium. Metamizole sodium is a non-opioid compound with excellent analgesic and antipyretic effects. Metamizole sodium is a **cyclooxygenase-3 (COX-3)** inhibitor.

HY-10284S1

Linagliptin-13C,d3 BI 1356-13C,D3	Dipeptidyl Peptidase Autophagy Ferroptosis	Metabolic Disease
Linagliptin-13C,d3 is the 13C- and deuterium labeled. Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM.

HY-Y0966S10

Glycine-d3	Endogenous Metabolite iGluR	Cancer
Glycine-d3 is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-B0495S

Lamotrigine-13C3,d3 LTG-13C3,D3; BW430C-13C3,D3	Sodium Channel Autophagy	Neurological Disease
Lamotrigine-13C3,d3 (LTG-13C3,d3) is the 13C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na⁺ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al.

HY-32329S

Setiptiline-d3	5-HT Receptor Adrenergic Receptor	Neurological Disease
Setiptiline-d3 (Org-8282-d3) is the deuterium labeled Setiptiline. Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine.

HY-B0368S

Captopril-d3 SQ 14225-D3	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Captopril-d3 is deuterium labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 7.9 μM.

HY-W004283S1

Pentadecanoic acid-d3	Endogenous Metabolite	Others
Pentadecanoic acid-d3 is the deuterium labeled Pentadecanoic acid. Pentadecylic acid is a saturated fatty acid with a 15-carbon backbone.

HY-B0207AS1

Pyridostigmine-d3 bromide	AChE	Neurological Disease
Pyridostigmine-d3 bromide is the deuterium labeled Pyridostigmine bromide. Pyridostigmine bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.

HY-17569S

Difluprednate-d3		Inflammation/Immunology
Difluprednate-d3 is the deuterium labeled Difluprednate. Difluprednate (Durezol), a corticosteroid, is thought to act by the induction of phospholipase A2 inhibitory proteins (lipocortins). Difluprednate is approved difluprednate for the treatment of post-operative ocular inflammation and pain.

HY-17410S

Iloperidone-d3	5-HT Receptor Dopamine Receptor	Neurological Disease
Iloperidone-d3 is the deuterium labeled Iloperidone. Iloperidone (HP 873) is a D₂/5-HT₂ receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms.

HY-14369S

Elagolix-13C,d3 sodium NBI-56418-13C,D3 sodium	GnRH Receptor	Endocrinology Cancer
Elagolix-13C,d3 (sodium) is the 13C- and deuterium labeled. Elagolix sodium is a human GnRH receptor (GnRHR) antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively.

HY-W012499S

N-Acetyl-L-methionine-d3 N-Acetylmethionine-D3	Endogenous Metabolite
N-Acetyl-L-methionine-d3 is the deuterium labeled N-Acetyl-L-methionine. N-Acetyl-L-methionine, a human metabolite, is nutritionally and metabolically equivalent to L-methionine. L-methionine is an indispensable amino acid required for normal growth and development.

HY-78131S1

Ibuprofen-13C,d3 (±)-Ibuprofen-13C,D3	COX	Inflammation/Immunology Cancer
Ibuprofen-13C,d3 is the 13C- and deuterium labeled. Ibuprofen is an anti-inflammatory agent targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.

HY-B1095S2

Chlormadinone acetate-d3	Progesterone Receptor
Chlormadinone acetate-d3 is the deuterium labeled Chlormadinone acetate. Chlormadinone acetate is a steroidal progestin, with antiandrogen and antiestrogenic effects.

HY-W013049S3

Docosanoic acid-d3	Endogenous Metabolite
Docosanoic acid-d3 is the deuterium labeled Docosanoic acid. Docosanoic acid is poorly absorbed, and a cholesterol-raising saturated fatty acid in humans.

HY-B0524AS

Betahistine-d3 dihydrochloride	Histamine Receptor	Endocrinology Inflammation/Immunology Neurological Disease
Betahistine-d3 dihydrochloride is the deuterium labeled Betahistine dihydrochloride. Betahistine dihydrochloride is an orally active histamine H1 receptor agonist and a H3 receptor antagonist. Betahistine dihydrochloride is used for the study of rheumatoid arthritis (RA).

HY-B1490S1

Imipramine-d3 hydrochloride	Serotonin Transporter	Neurological Disease
Imipramine-d3 (hydrochloride) is deuterium labeled Imipramine (hydrochloride). Imipramine hydrochloride inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine hydrochloride is reported to prevent the translocation of aSMase, inhibiting MV and exosomes secretion.

HY-17396S

Butenafine-13C,d3 hydrochloride KP363-13C,D3 hydrochloride	Fungal Antibiotic	Infection
Butenafine-13C,d3 (hydrochloride) is the 13C- and deuterium labeled. Butenafine Hydrochloride (KP363 Hydrochloride) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.

HY-13683S1

Mifepristone-13C,d3 RU486-13C,D3; RU 38486-13C,D3	Progesterone Receptor Glucocorticoid Receptor NO Synthase Autophagy	Endocrinology Cancer
Mifepristone-13C,d3 is the 13C- and deuterium labeled. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay.

HY-112094S

WNK-IN-11-d3	Ser/Thr Protease	Cardiovascular Disease
WNK-IN-11 D3 is an orally active, selective and potent With-No-Lysine (WNK) kinase inhibitor. WNK-IN-11 D3 is effective at regulating cardiovascular homeostasis.

HY-N0504S

Epi Lovastatin-d3	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Epi Lovastatin-d3 is the deuterium labeled Lovastatin. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-B1378S

Ethosuximide-d3	Calcium Channel	Neurological Disease
Ethosuximide-d3 is the deuterium labeled Ethosuximide. Ethosuximide, a widely prescribed anti-epileptic drug, improves the phenotypes of multiple neurodegenerative disease models and blocks the low voltage activated T-type calcium channel.

HY-B0518AS

Naftifine-d3 hydrochloride	Fungal Antibiotic	Infection
Naftifine-d3 hydrochloride is the deuterium labeled Naftifine hydrochloride. Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition.

HY-B0612DS1

Lercanidipine-d3 hydrochloride	Calcium Channel	Cardiovascular Disease
Lercanidipine-d3 hydrochloride is the deuterium labeled Lercanidipine. Lercanidipine is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine has long lasting antihypertensive action and reno-protective effect.

HY-12215S

Lorlatinib-13C,d3 PF-06463922-13C,D3	ALK ROS Apoptosis	Cancer
Lorlatinib-13C,d3 (PF-06463922-13C,d3) is the 13C- and deuterium labeled Lorlatinib. Lorlatinib (PF-06463922) is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor. Lorlatinib has K_is of <0.025 nM, <0.07 nM, and 0.7 nM for ROS1, wild type ALK, and ALK^L1196M, respectively. Lorlatinib has anticancer activity.

HY-B0165AS

Pravastatin-13C,d3 sodium CS-514-13C,D3 sodium	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Pravastatin-13C,d3 (sodium) is the 13C- and deuterium labeled. Pravastatin sodium (CS-514 sodium) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.

HY-N0060BS

(E)-Ferulic acid-d3 (E)-Coniferic acid-D3	β-catenin Bcl-2 Family Ferroptosis Endogenous Metabolite	Cancer
(E)-Ferulic acid-d3 ((E)-Coniferic acid-d3) is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299.

HY-132405S

Desmethyl Naproxen-d3
COX Autophagy Others

Desmethyl Naproxen-d3 is deuterium labeled Desmethyl Naproxen. Desmethyl Naproxen is the metabolite of anti-inflammatory agent Naproxen.

HY-B0762S1

Acetyl-L-carnitine-d3-1 hydrochloride O-Acetyl-L-carnitine-D3-1 hydrochloride	Endogenous Metabolite	Neurological Disease
Acetyl-L-carnitine-d3-1 (O-Acetyl-L-carnitine-d3-1) hydrochloride is the deuterium labeled Acetyl-L-carnitine hydrochloride. Acetyl-L-carnitine hydrochloride is a blood-brain permeable acetyl ester of the amino acid L-carnitine found in the body. Acetyl-L-carnitine hydrochloride is often used as a dietary supplement, and exibits anti-stress-related psychiatric disorders.

HY-15885S

LY2119620-d3
mAChR Neurological Disease

LY2119620-d3 is the deuterium labeled LY2119620. LY2119620 is a high-affinity muscarinic M₂/M₄ receptor agonist.

HY-N7653S

Azaleatin-d3	Dipeptidyl Peptidase	Metabolic Disease
Azaleatin-d3 is the deuterium labeled Azaleatin. Azaleatin is an O-methylated flavonol isolated from Rhododendron species. Azaleatin is a dipeptidyl peptidase-IV inhibitor. Azaleatin can be used for the research of type-2 diabetes and obesity.

HY-B1256S

Cefuroxime-d3	Bacterial Antibiotic	Infection
Cefuroxime-d3 is deuterium labeled Cefuroxime (sodium). Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime sodium has a broad spectrum activity against Gram-positive and Gram-negative bacteria.

HY-B0517S

Mepivacaine-d3	Sodium Channel	Neurological Disease
Mepivacaine-d3 is the deuterium labeled Mepivacaine. Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization.

HY-12090S

Anacetrapib-d3	CETP	Cardiovascular Disease
Anacetrapib-d3 is the deuterium labeled Anacetrapib. Anacetrapib is a potent CETP inhibitor, with IC₅₀s of 7.9±2.5 nM and 11.8±1.9 nM for rhCETP and C13S CETP mutant, respectively.

HY-12705S

Bromocriptine-13C,d3	Dopamine Receptor	Neurological Disease
Bromocriptine-13C,d3 is the 13C- and deuterium labeled. Bromocriptine is a potent dopamine D2/D3 receptor agonist, which binds D2 dopamine receptor with pKi of 8.05±0.2.

HY-N2381S

Menthone-d3	Parasite	Infection Inflammation/Immunology
Menthone-d3 is the deuterium labeled Menthone. Menthone, a monoterpene extracted from plants and Mentha oil with strong antioxidant properties. Menthone is a main volatile component of the essential oil, and has anti-Inflammatory properties in Schistosoma mansoni Infection.

HY-B0261S

Meloxicam-d3	COX Autophagy Apoptosis	Cancer Inflammation/Immunology
Meloxicam-d3 is deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC₅₀s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.

HY-18610S

Diclofensine-d3 hydrochloride	Dopamine Transporter	Neurological Disease
Diclofensine-d3 hydrochloride is the deuterium labeled Diclofensine hydrochloride. Diclofensine hydrochloride (Ro-8-4650 hydrochloride) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC₅₀ values of 0.74, 2.3, and 3.7 nM, respectively.

HY-70050AS1

Alosetron-13C,d3 GR 68755-13C,D3; GR 68755X-13C,D3	5-HT Receptor	Inflammation/Immunology Neurological Disease
Alosetron-13C,d3 (GR 68755-13C,d3) is the 13C- and deuterium labeled Alosetron. Alosetron (GR 68755) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC₅₀ at ~55 nM. Alosetron attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects.

HY-B0462S

Azelastine-13C,d3 hydrochloride	Histamine Receptor SARS-CoV	Infection Endocrinology Metabolic Disease Inflammation/Immunology
Azelastine-13C,d3 hydrochloride is the 13C- and deuterium labeled Azelastine hydrochloride. Azelastine-13C,d3 hydrochloride, an antihistamine, is a potent and selective histamine 1 (H₁) antagonist. Azelastine-13C,d3 hydrochloride can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2.

HY-34740S

Ethylmalonic acid-d3	Endogenous Metabolite	Metabolic Disease Neurological Disease
Ethylmalonic acid-d3 is the deuterium labeled Ethylmalonic acid. Ethylmalonic acid is non-carcinogenic potentially toxic and associated with anorexia nervosa and malonyl-CoA decarboxylase deficiency.

HY-16060S2

Apalutamide-13C,d3 ARN-509-13C,D3	Androgen Receptor	Cancer
Apalutamide-13C,d3 is the 13C- and deuterium labeled. Apalutamide (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM.

HY-10888S

Istradefylline-13C,d3 KW-6002-13C,D3	Adenosine Receptor	Neurological Disease
Istradefylline-13C,d3 is the 13C- and deuterium labeled. Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with Ki of 2.2 nM in experimental models of Parkinson's disease.

HY-115968

Dopamine D3 receptor ligand-4	Dopamine Receptor	Neurological Disease
Dopamine D3 receptor ligand-4 (compound 6) is a potent and selective dopamine D₃ receptor ligand, with a K_i of 0.5 nM. Dopamine D3 receptor ligand-4 shows high level of selectivity for D₃ over D₂ (K_i=7.43 nM). Dopamine D3 receptor ligand-4 can be used for the research of Cocaine use disorder.

HY-124422S

Pentacosanoic acid-d3	Endogenous Metabolite	Metabolic Disease
Pentacosanoic acid-d3 is the deuterium labeled Pentacosanoic acid. Pentacosanoic acid is a 25-carbon long-chain saturated fatty acid. Pentacosanoic is a conjugate acid of a pentacosanoate.

HY-N0326S7

L-Methionine-d3	Endogenous Metabolite	Others
L-Methionine-d3 is the deuterium labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.

HY-Y0252S1

L-Proline-d3	Endogenous Metabolite	Others
L-Proline-d3 is the deuterium labeled L-Proline. L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.

HY-B2219S3

Stearic acid-d3	Endogenous Metabolite	Cancer Metabolic Disease
Stearic acid-d3 is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.

HY-B1658CS

ent-Frovatriptan-d3 succinate

ent-Frovatriptan-d3 (succinate) is deuterium labeled ent-Frovatriptan.
HY-107867S3

(Rac)-Clopidogrel-d3 sulfate

(Rac)-Clopidogrel-d3 (sulfate) is deuterium labeled Clopidogrel (sulfate).
HY-142125S1

7-Hydroxy Granisetron-d3

7-Hydroxy Granisetron-d3 is deuterium labeled Broussochalcone A.
HY-143938S

Cyclobenzaprine impurity 2-d3 hydrochloride

Cyclobenzaprine impurity 2-d3 (hydrochloride) 是 Cyclobenzaprine impurity 2氘代物。
HY-144142S

Orphenadrine impurity 6-d3 hydrochloride

Orphenadrine impurity 6-d3 (hydrochloride) 是 Orphenadrine impurity 6氘代物。
HY-144141S

Nortriptyline impurity 3-d3 hydrochloride

Nortriptyline impurity 3-d3 (hydrochloride) 是 Nortriptyline impurity 3氘代物。
HY-143956S

Fluorofenidone impurity 1-d3

Fluorofenidone impurity 1-d3 是 Fluorofenidone impurity 1氘代物。
HY-143954S

Epinephrine impurity 19-d3 hydrochloride

Epinephrine impurity 19-d3 (hydrochloride) 是 Epinephrine impurity 19氘代物。

HY-B0330S1

(S)-Ofloxacin-d3	Bacterial Antibiotic	Infection
(S)-Ofloxacin-d3 is the deuterium labeled Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

HY-75766S

Methylnaltrexone-d3 bromide	Opioid Receptor	Neurological Disease
Methylnaltrexone D3 Bromide is the deuterium labeled Methylnaltrexone Bromide. Methylnaltrexone Bromide is a peripheral-acting opioid receptor antagonist that acts on the gastrointestinal tract to decrease opioid-induced constipation.

HY-40135S

L-Hydroxyproline-d3	Endogenous Metabolite	Others
L-Hydroxyproline-d3 is the deuterium labeled L-Hydroxyproline. L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.

HY-131103S

Phenylethanolamine A-D3	Adrenergic Receptor	Metabolic Disease Inflammation/Immunology
Phenylethanolamine A-D3 is a deuterium labeled Phenylethanolamine A. Phenylethanolamine A acts as a β-adrenergic agonist. Phenylethanolamine A is a byproduct during the Ractopamine synthesis process.

HY-B1188S

Propantheline-d3 bromide	mAChR	Neurological Disease
Propantheline-d3 bromide is the deuterium labeled Propantheline bromide. Propantheline bromide is an antimuscarinic agent, used for the treatment of hyperhidrosis, cramps or spasms of the stomach, intestines or bladder, and enuresis.

HY-N0473S15

L-Tyrosine-d3	Endogenous Metabolite
L-Tyrosine-d3 is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-B0369AS

Orphenadrine-d3 citrate	iGluR	Neurological Disease
Orphenadrine-d3 citrate is the deuterium labeled Orphenadrine citrate. Orphenadrine citrate is a NMDA receptor antagonist with K_i of 6.0 +/- 0.7 μM, HERG potassium channel blocker.

HY-W007720S

Fmoc-Ser-OH-d3

Fmoc-Ser-OH-d3 is the deuterium labeled Fmoc-Ser-OH.
HY-B0157S

Ketotifen-13C,d3
Endogenous Metabolite

Ketotifen-13C,d3 is deuterium labeled Ketotifen.
HY-W001158S1

N,N-Dimethylglycine-d3 hydrochloride

N,N-Dimethylglycine-d3 (hydrochloride) is the deuterium labeled N,N-Dimethylglycine.
HY-W008371S2

Fmoc-Met-OH-d3

Fmoc-Met-OH-d3 is the deuterium labeled Fmoc-Met-OH.
HY-W013780S3

Fmoc-Pro-OH-d3

Fmoc-Pro-OH-d3 is the deuterium labeled Fmoc-Pro-OH.
HY-120422S

N-Desmethyl Regorafenib-d3

N-Desmethyl Regorafenib-d3 is deuterium labeled BAY-751098.

HY-B1395S

Mecamylamine-d3 hydrochloride	nAChR	Neurological Disease
Mecamylamine-d3 hydrochloride is the deuterium labeled Mecamylamine hydrochloride. Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist that can treat various neuropsychiatric disorders. Mecamylamine hydrochloride is originally used as a ganglionic blocker in treating hypertension. Mecamylamine hydrochloride can easily crosses the blood-brain barrier.

HY-16569S1

Colchicine-d3	Microtubule/Tubulin Autophagy Apoptosis	Cancer
Colchicine-d3 is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs).

HY-13955S

Telmisartan-d3	Angiotensin Receptor Autophagy	Cardiovascular Disease Endocrinology
Telmisartan-d3 is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of ¹²⁵I-AngII to AT1 receptors with IC₅₀ of 9.2 nM.

HY-10999S2

Trametinib-13C,d3 GSK1120212-13C,D3; JTP-74057-13C,D3	MEK Autophagy Apoptosis	Cancer
Trametinib-13C,d3 is the 13C- and deuterium labeled. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis.

HY-12201S

TAK-901-d3
Aurora Kinase Cancer

TAK-901-d3 is the deuterium labeled TAK-901. TAK-901 is a multi-targeted aurora inhibitor with IC₅₀s of 21 and 15 nM for aurora A and B, respectively.

HY-113340S

2-Furoylglycine-d3	Endogenous Metabolite	Others
2-Furoylglycine-d3 is the deuterium labeled 2-Furoylglycine. 2-Furoylglycine, a urinary metabolite in human, is a putative biomarker for coffee consumption.

HY-N0486S9

L-Leucine-d3	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-d3 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.

HY-N0667S5

L-Asparagine-d3 hydrate	Endogenous Metabolite	Neurological Disease
L-Asparagine-d3 hydrate is the deuterium labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-10053S

Maropitant-d3	Neurokinin Receptor	Neurological Disease Endocrinology
Maropitant-d3 is the deuterium labeled Maropitant. Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting.

HY-141750S1

N-Desmethyl Zolmitriptan-d3

N-Desmethyl Zolmitriptan-d3 是 N-Desmethyl Zolmitriptan氘代物。
HY-144157S

N-Acetyl Retigabine-d3 dihydrochloride

N-Acetyl Retigabine-d3 (dihydrochloride) 是 N-Acetyl Retigabine氘代物。
HY-17583S1

Griseofulvin-13C,d3
Fungal Apoptosis Antibiotic Endogenous Metabolite Infection Cancer

Griseofulvin-13C,d3 is the 13C- and deuterium labeled.
HY-121950S

18-Methyleicosanoic acid-d3

18-Methyleicosanoic acid-d3 is the deuterium labeled 18-Methyleicosanoic acid.
HY-126857S

5-Hydroxy Omeprazole-d3

5-Hydroxy Omeprazole-d3 is deuterium labeled 5-Hydroxyomeprazole.
HY-143915S

Amitriptyline-N-glucuronide-d3

Amitriptyline-N-glucuronide-d3 是 Amitriptyline-N-glucuronide氘代物。
HY-B0164S

Mizolastine-13C,d3
Histamine Receptor Inflammation/Immunology Endocrinology

Mizolastine-13C,d3 is the 13C- and deuterium labeled.
HY-144143S

N-Desmethyl Olopatadine-d3 hydrochloride

N-Desmethyl Olopatadine-d3 (hydrochloride) 是 N-Desmethyl Olopatadine氘代物。
HY-14151S

Prucalopride-13C,d3
5-HT Receptor Neurological Disease

Prucalopride-13C,d3 is the 13C- and deuterium labeled.

HY-B1192S

Estradiol benzoate-d3 β-Estradiol 3-benzoate-D3; 17β-Estradiol 3-benzoate-D3	Estrogen Receptor/ERR
Estradiol benzoate-d3 is the deuterium labeled Estradiol benzoate. Estradiol Benzoate (β-Estradiol 3-benzoate), a prodrug of estradiol, acts as a steroid sex hormone. It exhibits mild anabolic and metabolic properties, and increases blood coagulability.

HY-135372S

Descarbamoyl Cefuroxime-d3	Drug Metabolite	Infection
Descarbamoyl Cefuroxime-d3 is the deuterium labeled Descarbamoyl cefuroxime. Descarbamoyl cefuroxime is a degradation product of Cefuroxime. Descarbamoyl cefuroxime is also an intermediate for the synthesis of Cephalosporin antibiotics.

HY-B0330DS

(R)-Ofloxacin-d3	Bacterial Antibiotic	Infection
(R)-Ofloxacin-d3 is the deuterium labeled (R)-Ofloxacin. (R)-Ofloxacin (Dextrofloxacin) is an antibiotic useful for the treatment of a number of bacterial infections. Antibacterial activity.

HY-113076S

Thiamine pyrophosphate-d3	Endogenous Metabolite	Metabolic Disease
Thiamine pyrophosphate-d3 is the deuterium labeled Thiamine pyrophosphate. Thiamine pyrophosphate is the coenzyme form of Vitamin B1 and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex.

HY-17021S1

Esomeprazole-d3	Proton Pump	Cancer Endocrinology Inflammation/Immunology
Esomeprazole-d3 is deuterium labeled Esomeprazole. Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research.

HY-B1227S

Carprofen-d3	COX FAAH Autophagy Endogenous Metabolite	Inflammation/Immunology
Carprofen-d3 is the deuterium labeled Carprofen. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC₅₀s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-17021S

Esomeprazole-d3 sodium	Proton Pump	Cancer Endocrinology Inflammation/Immunology
Esomeprazole-d3 sodium is the deuterium labeled Esomeprazole. Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H⁺, K⁺-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research.

HY-Z0792S

4-O-Methyldopa-d3
Endogenous Metabolite

4-O-Methyldopa-d3 is deuterium labeled 4-O-Methyldopamine.

HY-17492S1

Zafirlukast-13C,d3 ICI 204219-13C,D3	Leukotriene Receptor	Inflammation/Immunology Cancer
Zafirlukast-13C,d3 is the 13C- and deuterium labeled. Zafirlukast (ICI 204219) is a potent orally active leukotriene D4 (LTD4) receptor antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects.

HY-N0626S

Sorbic acid-d3	Fungal Bacterial Endogenous Metabolite Antibiotic	Infection
Sorbic acid-d3 is the deuterium labeled Sorbic acid. Sorbic acid is a highly efficient, and nonpoisonous food preservative. Sorbic acid generally is an effective inhibitor of most molds and yeasts and some bacteria.

HY-N2041S3

Myristic acid-d3	Endogenous Metabolite	Others
Myristic acid-d3 is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.

HY-B0510S2

Trimethoprim-d3	Antifolate Bacterial Antibiotic	Infection
Trimethoprim-D3 is the deuterium labeled Trimethoprim. Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment.

HY-119696S

MTIC-d3	Drug Metabolite	Cancer Neurological Disease
MTIC-d3 is deuterium labeled MTIC. MTIC is the active metabolite of Temozolomide (TMZ). MITC has lower bioavailability in the brain compared with TMZ, because the drug’s permeability through biological barriers and tumor cell membranes affects bioavailability. MITC exhibits low affinity to biological membrane.

HY-U00244S

Benzquinamide-d3 hydrochloride	Adrenergic Receptor	Metabolic Disease Endocrinology
Benzquinamide-d3 hydrochloride is the deuterium labeled Benzquinamide hydrochloride. Benzquinamide (P2647) is an antiemetic which can bind to the α_2A, α_2B, and α_2C adrenergic receptors (α2-AR) with K_i values of 1,365, 691, and 545 nM, respectively.

HY-A0009S

Galanthamine-d3 hydrobromide Galantamine-D3 hydrobromide	AChE nAChR	Neurological Disease
Galanthamine-d3 (hydrobromide) is deuterium labeled Galanthamine (hydrobromide). Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC50 of 0.35 µM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α3β4, α4β2, α6β4 nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD).

HY-144248S

Levomedetomidine-13C,d3 hydrochloride

Levomedetomidine-13C,d3 (hydrochloride) is the 13C- and deuterium labeled.
HY-144148S

Pyroxsulam-13C,d3

Pyroxsulam-13C,d3 is the 13C- and deuterium labeled.
HY-B1845S

Florasulam-13C,d3

Florasulam-13C,d3 is the 13C- and deuterium labeled.

HY-B0957S

Erythromycin ethylsuccinate-13C,d3 Erythromycin ethyl succinate-13C,D3; EES-13C,D3	Bacterial HIV Autophagy Antibiotic	Infection
Erythromycin ethylsuccinate-13C,d3 is the 13C- and deuterium labeled. Erythromycin Ethylsuccinate is an antibiotic useful for the treatment of a number of bacterial infections, has an antimicrobial spectrum similar to or slightly wider than that of penicillin. Erythromycin Ethylsuccinate has antiviral activity against HIV-1.

HY-76251S

(R)-(-)-Etodolac-d3	COX	Inflammation/Immunology Cancer
(R)-(-)-Etodolac-d3 is the deuterium labeled Etodolac. Etodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC₅₀=53.5 nM)

HY-17512S1

Losartan-d3 Carboxylic Acid	Angiotensin Receptor	Cardiovascular Disease Endocrinology Cancer
Losartan-d3 Carboxylic Acid is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC₅₀ of 20 nM.

HY-B1799S

Tolmetin-d3	COX	Cancer Inflammation/Immunology
Tolmetin-d3 is the deuterium labeled Tolmetin. Tolmetin is an orally active and potent COX inhibitor with IC₅₀s of 0.35 µM and 0.82 µM human COX-1 and COX-2, respectively. Tolmetin is a non-steroidal anti-inflammatory drug (NSAID).

HY-118827S

Vedaprofen-d3	COX	Inflammation/Immunology
Vedaprofen-d3 is the deuterium labeled Vedaprofen. Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory drug (NSAID) for serum TxB2 and exudate PGE2 inhibition . Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC₅₀ of 222 μM.

HY-B0849S1

Azoxystrobin-d3	Fungal Reactive Oxygen Species Apoptosis	Infection
Azoxystrobin-d3 is deuterium labeled Azoxystrobin. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.

HY-W011117S

Danofloxacin-d3	Bacterial DNA/RNA Synthesis	Infection
Danofloxacin-d3 is deuterium labeled Danofloxacin. Danofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent. Danofloxacin shows a broad spectrum of activity against most Gram-negative and Gram-positive bacteria, mycoplasma and chlamydia species, and plays an antimicrobial role by inhibition of bacterial DNA-gyrase.

HY-B0310S

Nizatidine-d3	Histamine Receptor	Cancer Endocrinology Inflammation/Immunology
Nizatidine-d3 is the deuterium labeled Nizatidine. Nizatidine is a potent and orally active histamine H₂ receptor antagonist, can be used for the research of stomach and intestines ulcers. Nizatidine works by decreasing the secretion of gastric acid the stomach makes and prevent ulcers from coming back after they have healed in animal models.

HY-17034AS

Dexmedetomidine-13C,d3 hydrochloride (+)-Medetomidine-13C,D3 hydrochloride; (S)-Medetomidine-13C,D3 hydrochloride	Adrenergic Receptor	Neurological Disease Endocrinology Cancer
Dexmedetomidine-13C,d3 (hydrochloride) is the 13C- and deuterium labeled. Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects.

HY-N3595S

Cleomiscosin A-d3	TNF Receptor	Inflammation/Immunology
Cleomiscosin A-d3 is the deuterium labeled Cleomiscosin A. Cleomiscosin A is a coumarino-lignoid from branch of Macaranga adenantha. Cleomiscosin A is active against TNF-alpha secretion of the mouse peritoneal macrophages.

HY-N0708S

Vanillic acid-d3	NF-κB Bacterial Endogenous Metabolite	Infection Inflammation/Immunology
Vanillic acid-d3 is the deuterium labeled Vanillic acid. Vanillic acid is a flavoring agent found in edible plants and fruits. Vanillic acid inhibits NF-κB activation. Anti-inflammatory, antibacterial, and chemopreventive effects.

HY-B0176AS1

(±)-cis-Sertraline-d3 hydrochloride	Serotonin Transporter	Neurological Disease
(±)-cis-Sertraline-d3 hydrochloride is the deuterium labeled Sertraline hydrochloride. Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive.

HY-B0176AS

rel-Sertraline-d3 hydrochloride	Serotonin Transporter	Neurological Disease
rel-Sertraline-d3 hydrochloride is the deuterium labeled Sertraline hydrochloride. Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive.

HY-13629S1

Etoposide-13C,d3 VP-16-13C,D3; VP-16-213-13C,D3	Topoisomerase Autophagy Mitophagy Bacterial Apoptosis Antibiotic	Cancer Infection
Etoposide-13C,d3 is the 13C- and deuterium labeled. Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy.

HY-W004066S

Ac-Ala-OH-d3
Endogenous Metabolite

Ac-Ala-OH-d3 is the deuterium labeled Ac-Ala-OH. Ac-Ala-OH is an endogenous metabolite.

HY-76299S1

Galanthamine-O-methyl-d3	AChE Apoptosis	Neurological Disease
Galanthamine-O-methyl-d3 is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM.

HY-13955S2

Telmisartan-13C,d3 BIBR 277-13C,D3	Angiotensin Receptor Autophagy	Cardiovascular Disease Endocrinology
Telmisartan-13C,d3 is the 13C- and deuterium labeled. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.

HY-B1213S

Trimipramine-d3 maleate	5-HT Receptor Bacterial	Neurological Disease
Trimipramine-d3 maleate is the deuterium labeled Trimipramine maleate. Trimipramine maleate is a 5-HT receptor antagonist, with pK_is of 6.39, 8.10, 4.66 for 5-HT_1C, 5-HT₂ and 5-HT_1A, respectively.

HY-B0262S1

Methocarbamol-d3	Sodium Channel	Neurological Disease
Methocarbamol-d3 is the deuterium labeled Methocarbamol. Methocarbamol is an orally active central muscle relaxant and blocks muscular Nav1.4 channel. Methocarbamol reversibly affects voltage dependence of inactivation of Nav1.4 channel. Methocarbamol has the potential for muscle spasms and pain syndromes research.

HY-16579AS

Etifoxine-d3	GABA Receptor	Neurological Disease
Etifoxine-d3 is the deuterium labeled Etifoxine. Etifoxine, a non-benzodiazepine GABAergic compound, is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABA_A receptors. Etifoxine reveals anxiolytic and anticonvulsant properties in rodents.

HY-B0309S2

Felodipine-d3	Calcium Channel Autophagy	Cardiovascular Disease
Felodipine-d3 is the deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier.

HY-W018004S

L-Homocitrulline-d3	Endogenous Metabolite	Metabolic Disease
L-Homocitrulline-d3 is the deuterium labeled L-Homocitrulline. L-Homocitrulline is metabolized to homoarginine through homoargininosuccinate via the urea cycle pathway and its metabolic abnormality could lead to Lysinuric Protein Intolerance (LPI).

HY-13604S

Cyproterone acetate-d3	Androgen Receptor	Cancer Endocrinology
Cyproterone acetate-d3 is deuterium labeled Cyproterone acetate. Cyproterone acetate is an anti-androgen (IC50=7.1 nM) and progestogen synthetic steroid. Cyproterone acetate has affinity with progesteron and with glucocorticoidal receptors.

HY-W015309S

Decanoic acid-d3	iGluR	Neurological Disease
Decanoic acid-d3 is the deuterium labeled Decanoic acid. Decanoic acid, a component of medium chain triclycerides, is a brain-penetrant and non-competitive inhibitor of AMPA receptor. Decanoic acid has antiseizure effects.

HY-133588S

4-Formylaminoantipyrine-d3	Endogenous Metabolite	Metabolic Disease
4-Formylaminoantipyrine-d3 is the deuterium labeled 4-Formylaminoantipyrine. 4-Formylaminoantipyrine is an excreted metabolite of aminophenazone. Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic effects in vivo.

HY-15321S1

Etoricoxib-13C,d3 MK-0663-13C,D3; L-791456-13C,D3	COX	Inflammation/Immunology Cancer
Etoricoxib-13C,d3 is the 13C- and deuterium labeled. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

HY-113165AS

Isobutyryl-L-carnitine-d3 chloride	Endogenous Metabolite	Metabolic Disease
Isobutyryl-L-carnitine-d3 chloride is the deuterium labeled Isobutyryl-L-carnitine chloride. Isobutyryl-L-carnitine chloride is a product of the acyl-CoA dehydrogenases.

HY-135212S

Hydroxy ipronidazole-d3	Endogenous Metabolite	Metabolic Disease
Hydroxy ipronidazole-d3 is the deuterium labeled Hydroxy ipronidazole. Hydroxy ipronidazole (Ipronidazole-OH) is a metabolite of nitroimidazole antibiotics, such as ipronidazole (IPZ). Hydroxy ipronidazole may has similar mutagenic potential as the parent compound.

HY-14153AS

Tegaserod-13C,d3 maleate SDZ-HTF-919-13C,D3; HTF-919-13C,D3	5-HT Receptor	Metabolic Disease Neurological Disease
Tegaserod-13C,d3 (maleate) is the 13C- and deuterium labeled. Tegaserod maleate is a selective 5-HT4 receptor partial agonist and a 5-HT2B receptor antagonist. Tegaserod maleate exhibits a promotile effect throughout the gastrointestinal (GI) tract.

HY-117743S

Eprosartan-d3	Angiotensin Receptor	Cardiovascular Disease
Eprosartan-d3 is the deuterium labeled Eprosartan. Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC₅₀s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .

HY-B0372AS

Bromhexine-d3 hydrochloride	SARS-CoV Autophagy HIV	Metabolic Disease
Bromhexine-d3 (hydrochloride) is deuterium labeled Bromhexine (hydrochloride). Bromhexine hydrochloride is a potent and specific TMPRSS2 protease inhibitor with an IC50 of 0.75 μM. Bromhexine hydrochloride can prevent and manage SARS-CoV-2 infection. Bromhexine hydrochloride is an autophagy agonist. Bromhexine hydrochloride is a mucolytic cough suppressant and has the potential for a range of respiratory conditions.

HY-B0495S1

Lamotrigine-13C,d3 LTG-13C,D3; BW430C-13C,D3	Sodium Channel Autophagy	Neurological Disease
Lamotrigine-13C,d3 is the 13C- and deuterium labeled. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al.

HY-Y0366S3

Lauric acid-d3	Endogenous Metabolite Bacterial	Infection
Lauric acid-d3 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC₅₀s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-B0227S2

Ketoprofen-13C,d3 RP-19583-13C,D3	COX Apoptosis	Inflammation/Immunology
Ketoprofen-13C,d3 is the 13C- and deuterium labeled. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively.

HY-136441S

Triclosan-methyl-d3	Bacterial	Infection
Triclosan-methyl-d3 is the deuterium labeled Triclosan-methyl. Triclosan-methyl is a transformation product of triclosan. Triclosan is a bactericide in personal care products such as toothpaste, shampoos, and soaps. Triclosan is also a stabilizing agent in a multitude of detergents and cosmetics.

HY-10163S3

Dabigatran-13C,d3 BIBR 953-13C,D3; BIBR 953ZW-13C,D3	Thrombin	Cardiovascular Disease
Dabigatran-13C,d3 is the 13C- and deuterium labeled. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM).

HY-B0413S

Fenbendazole-d3	Parasite HIF/HIF Prolyl-Hydroxylase Antibiotic	Infection
Fenbendazole-d3 is a deuterium labeled Fenbendazole. Fenbendazole is a benzimidazole anthelmintic. Fenbendazole is active against Giardia in vitro (IC₅₀ = 0.3 μM). Fenbendazole (20 mg/kg) prevents infiltration of parasites into the brain in a rabbit model of E. cuniculi infection. Fenbendazole also activates HIF-1α and prevents oxidative stress-induced death in primary neurons in vitro.

HY-15455S2

Roflumilast-d3	Phosphodiesterase (PDE) RSV	Inflammation/Immunology
Roflumilast-d3 is deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells.

HY-B0294S

Flubendazole-d3	Parasite Microtubule/Tubulin Apoptosis	Cancer Infection
Flubendazole-d3 is the deuterium labeled Flubendazole. Flubendazole is a safe and efficacious anthelmintic drug, which is widely used for anthelmintic to human, rodents and ruminants. Flubendazole exerts anticancer activities by mechanisms including inhibition of microtubule function. Flubendazole induces p53-mediated apoptosis and arrests G2/M cell cycle.

HY-B1462S

Chlorzoxazone-d3	Cytochrome P450	Inflammation/Immunology
Chlorzoxazone-d3 is the deuterium labeled Chlorzoxazone. Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes.Chlorzoxazone is currently being used as a marker substrate in vitro/vivo studies to quantify cytochrome P450 2E1 (CYP2E1) activity in humans.

HY-133112S

7-Desmethyl-3-hydroxyagomelatine-d3 3-Hydroxy-7-desmethyl agomelatine-D3	Melatonin Receptor 5-HT Receptor	Neurological Disease
7-Desmethyl-3-hydroxyagomelatine-d3 (3-Hydroxy-7-desmethyl agomelatine-d3) is the deuterium labeled 7-Desmethyl-3-hydroxyagomelatine. 7-Desmethyl-3-hydroxyagomelatine (3-Hydroxy-7-desmethyl agomelatine), a metabolite of Agomelatine, has less activity than Agomelatine. Agomelatine is a melatonergic (MT1 and MT2) agonist and serotonergic (5HT2C) antagonist.

HY-N0469S

L-Lysine-d3 hydrochloride	Endogenous Metabolite Virus Protease	Inflammation/Immunology
L-Lysine-d3 hydrochloride is the deuterium labeled L-Lysine. L-lysine is an essential amino acid with important roles in connective tissues and carnitine synthesis, energy production, growth in children, and maintenance of immune functions.

HY-N0168AS

(Rac)-Hesperetin-d3	p38 MAPK Apoptosis Autophagy	Cancer Neurological Disease
(Rac)-Hesperetin-d3 is the deuterium labeled (Rac)-Hesperetin. (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.

HY-B0261S1

Meloxicam-d3-1	COX Autophagy Apoptosis	Inflammation/Immunology Cancer
Meloxicam-d3-1 is the deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC₅₀s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.

HY-N0666S2

DL-Aspartic acid-d3	Endogenous Metabolite	Cardiovascular Disease
DL-Aspartic acid-d3 is the deuterium labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.

HY-N0666S8

L-Aspartic acid-d3	Endogenous Metabolite	Cardiovascular Disease
L-Aspartic acid-d3 is the deuterium labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.

HY-16567S

Asenapine-13C,d3 hydrochloride	5-HT Receptor Dopamine Receptor	Neurological Disease
Asenapine-13C,d3 (hydrochloride) is the 13C- and deuterium labeled. Asenapine hydrochloride, an antipsychotic, is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and Dopamine (D2, D3, D4) receptor antagonist with Ki values of 0.03-4.0 nM for 5-HT and 1.3, 0.42, 1.1 nM for Dopamine receptor, respectively.

HY-B0712S

Ceftriaxone-d3 disodium	Bacterial Antibiotic	Infection
Ceftriaxone-d3 disodium is the deuterium labeled Ceftriaxone. Ceftriaxone is a third-generation cephalosporin antibiotic with excellent activity against many gram-negative, and reasonable activity against most gram-positive microorganisms. Anti-inflammatory and antioxidant characteristics.

HY-W004284S

Heptadecanoic acid-d3	Endogenous Metabolite	Cancer Metabolic Disease Cardiovascular Disease
Heptadecanoic acid-d3 is the deuterium labeled Heptadecanoic acid. Heptadecanoic acid is an odd chain saturated fatty acid (OCS-FA). Heptadecanoic acid is associated with several diseases, including the incidence of coronary heart disease, prediabetes and type 2 diabetes as well as multiple sclerosis.

HY-N0650S3

L-Serine-13C3,15N,d3 (-)-Serine-13C3,15N,D3; (S)-Serine-13C3,15N,D3	Endogenous Metabolite	Cancer
L-Serine-13C3,15N,d3 ((-)-Serine-13C3,15N,d3; (S)-Serine-13C3,15N,d3) is the deuterium, 13C-, and 15-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

HY-135119

Salmeterol-D3	Adrenergic Receptor	Endocrinology Inflammation/Immunology
Salmeterol-D3 is a deuterium labeled Salmeterol. Salmeterol is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively.

HY-N1356S

Reticuline-d3	JAK STAT NF-κB Endogenous Metabolite	Inflammation/Immunology Cardiovascular Disease
Reticuline-d3 is the deuterium labeled Reticuline. Reticuline shows anti-inflammatory effects through *JAK2/STAT3* and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3. Reticuline exhibits cardiovascular effects.

HY-12532S

Astemizole-d3	Histamine Receptor Potassium Channel	Inflammation/Immunology Endocrinology
Astemizole-d3 is the deuterium labeled Astemizole. Astemizole (R 43512), a second-generation antihistamine drug to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC₅₀ of 4 nM. Astemizole also shows potent hERG K⁺ channel blocking activity with an IC₅₀ of 0.9 nM. Astemizole has antipruritic effects.

HY-18085S1

Quercetin-d3	PI3K Autophagy Mitophagy Reactive Oxygen Species Apoptosis	Cancer
Quercetin-d3 is the deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a *PI3K* inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.

HY-14282S

Lanoconazole-d3	Fungal	Infection Inflammation/Immunology
Lanoconazole-d3 is the deuterium labeled Lanoconazole. Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis.

HY-14656S1

Diltiazem-(acetoxy-d3) (hydrochloride)	Calcium Channel	Cardiovascular Disease
Diltiazem-(acetoxy-d3) hydrochloride is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca²⁺ influx inhibitor (slow channel blocker or calcium antagonist).

HY-116865S

Equilenin-4,16,16-d3

Equilenin-4,16,16-d3 is the deuterium labeled Equilenin-4,16,16.

HY-113121S

Vanillylmandelic acid-d3	Others Endogenous Metabolite	Cardiovascular Disease
Vanillylmandelic acid-d3 is the deuterium labeled Vanillylmandelic acid. Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC₅₀ value of 33 μM.

HY-B0259S

(rac)-Indapamide-d3	Potassium Channel	Cardiovascular Disease
(Rac)-Indapamide-d3 is a labelled racemic Indapamide. Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy.

HY-113081S

1-Methyladenosine-d3	Endogenous Metabolite	Others
1-Methyl Adenosine-d3 is the deuterium labeled 1-Methyladenosine. 1-Methyladenosine is an RNA modification originating essentially from two different reaction types, one catalyzed by enzymes and the other the result of the reaction of RNA with certain alkylating agents.

HY-A0166S

Cilastatin-15N,d3 MK0791-15N,D3	Bacterial Antibiotic	Infection
Cilastatin-15N,d3 is a 15N-labeled and deuterium labeled Cilastatin (MK0791) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC50 of 0.1 μM. Cilastatin inhibits the bacterial metallob-lactamase enzyme CphA with an IC50 of 178 μM. Cilastatin is an antibacterial adjunct.

HY-19740S

BIA 10-2474-d3	FAAH Autophagy	Neurological Disease
BIA 10-2474-d3 is the deuterium labeled BIA 10-2474. BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) with IC₅₀ values of 50 to 70mg/kg in various rat brain regions.

HY-B0280S2

Ranolazine-d3	Sodium Channel Calcium Channel	Cardiovascular Disease Cancer
Ranolazine-d3 is the deuterium labeled Ranolazine. Ranolazine (CVT 303) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (I_Na and I_Kr with IC₅₀ values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP). Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor. Antianginal agent.

HY-B0519AS

Tylosin-d3	Bacterial Antibiotic	Infection
Tylosin-d3 is the deuterium labeled Tylosin. Tylosin (Tylosin A) is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin is widely used as a feed additive for promoting animal growth. Tylosin is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle.

HY-116852S

Thiocolchicine-d3	Microtubule/Tubulin Apoptosis	Cancer
Thiocolchicine-d3 is deuterium labeled Thiocolchicine. Thiocolchicine, a derivative modified in the C Ring of Colchicine (HY-16569) with enhanced biological properties. Thiocolchicine is a potent inhibitor of tubulin polymerization (IC50=2.5 µM) and competitively binds to tubulin with a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.

HY-113263S

17a-Hydroxypregnenolone-d3	Endogenous Metabolite	Endocrinology
17a-Hydroxypregnenolone-d3 is the deuterium labeled 17a-Hydroxypregnenolone. 17a-Hydroxypregnenolone is a pregnane steroid. 17a-Hydroxypregnenolone is a prohormone in the formation of dehydroepiandrosterone (DHEA).

HY-19545AS

SCH-23390-d3 hydrochloride	Dopamine Receptor 5-HT Receptor Potassium Channel	Neurological Disease
SCH-23390-d3 (R-(+)-SCH-23390-d3) hydrochloride is the deuterium labeled SCH-23390 hydrochloride. SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D₁-like receptor antagonist with K_is of 0.2 nM and 0.3 nM for the D₁ and D₅ receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT_2C receptor agonist with a K_i of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT₂ and 5-HT_1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC₅₀ of 268 nM.

HY-W012908S2

H-DL-Pro-OH-d3

H-DL-Pro-OH-d3 is the deuterium labeled H-DL-Pro-OH.
HY-W009124S

Fmoc-D-Pro-OH-d3

Fmoc-D-Pro-OH-d3 is the deuterium labeled Fmoc-D-Pro-OH.
HY-W008072S

Fmoc-D-Ala-OH-d3

Fmoc-D-Ala-OH-d3 is the deuterium labeled Fmoc-D-Ala-OH.
HY-144147S

N-Methyl Quinidine-d3 iodide

N-Methyl Quinidine-d3 (iodide) 是 N-Methyl Quinidine氘代物。
HY-W009049S

D-Methionine-N-fmoc-d3

D-Methionine-N-fmoc-d3 is the deuterium labeled D-Methionine-N-fmoc.
HY-W007750S

H-Lys(Z)-OH-d3

H-Lys(Z)-OH-d3 is the deuterium labeled H-Lys(Z)-OH.

HY-17358S1

Loteprednol Etabonate-d3	Glucocorticoid Receptor Bacterial Antibiotic	Infection Endocrinology Inflammation/Immunology
Loteprednol Etabonate-d3 is the deuterium labeled Loteprednol Etabonate. Loteprednol etabonate (LE) is an orally active "soft" steroid belonging to a unique class of glucocorticoids. Loteprednol etabonate (LE) exhibits anti-inflammatory activity and has been used in optometry and ophthalmology.

HY-B0574S1

Mefenamic Acid-d3	COX	Inflammation/Immunology
Mefenamic Acid-d3 is the deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC₅₀s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.

HY-136450S1

Triclabendazole sulfoxide-13C,d3 TCBZ-SO-13C,D3	Parasite BCRP	Infection
Triclabendazole sulfoxide-13C,d3 is the 13C- and deuterium labeled. Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP.

HY-Y0337S5

L-Cysteine-d3	Endogenous Metabolite	Metabolic Disease
L-Cysteine-d3 is the deuterium labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans.

HY-B1325S

Cefuroxime axetil-d3	Bacterial Antibiotic	Infection
Cefuroxime axetil-d3 is the deuterium labeled Cefuroxime axetil. Cefuroxime Axetil, a prodrug of the cephalosporin cefuroxime and an oarl broad spectrum antibiotic, inhibits several gram-positive and gram-negative organisms, including those most frequently associated with various common community-acquired infections.

HY-144242S

Voriconazole EP impurity D-d3

Voriconazole EP impurity D-d3 是 Voriconazole EP impurity D氘代物。
HY-144144S

(E)-N-Desmethyl Olopatadine-d3 hydrochloride

(E)-N-Desmethyl Olopatadine-d3 (hydrochloride) 是 (E)-N-Desmethyl Olopatadine氘代物。

HY-77521S

Dabigatran ethyl ester-d3 hydrochloride	Thrombin	Cardiovascular Disease
Dabigatran ethyl ester-d3 hydrochloride is the deuterium labeled Dabigatran (ethyl ester hydrochloride). Dabigatran ethyl ester hydrochloride is a potent inhibitor of ribosyldihydronicotinamide dehydrogenase (NQO2) with an IC₅₀ value of 0.8 μM and a thrombin inhibitor.

HY-132561S

RPR121056-d3	Topoisomerase AChE	Cancer
RPR121056-d3 is the deuterium labeled RPR121056. RPR121056 is a metabolite of Irinotecan (CPT-11), which is generated by CYP3A4. Irinotecan (CPT-11) is an antineoplastic agent that inhibits topoisomerase type I, causing cell death, and is widely used in the treatment of colorectal cancer. Irinotecan also directly inhibits AChE.

HY-B0154S

Fluticasone propionate-d3	Glucocorticoid Receptor Enterovirus Endogenous Metabolite	Infection Endocrinology Inflammation/Immunology
Fluticasone propionate-d3 is the deuterium labeled Fluticasone propionate. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (K_D) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity.

HY-100807S

Quinolinic acid-d3	Endogenous Metabolite iGluR	Inflammation/Immunology Neurological Disease
Quinolinic acid-d3 is the deuterium labeled Quinolinic acid. Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction.

HY-143996S

Mevalonic acid-13C,d3 sodium

Mevalonic acid-13C,d3 (sodium) is the 13C- and deuterium labeled.
HY-B1234AS

(E)-Octinoxate-13C,d3

(E)-Octinoxate-13C,d3 is the 13C- and deuterium labeled.
HY-W010389S1

N-Acetyl-DL-alanine-d3

N-Acetyl-DL-alanine-d3 is the deuterium labeled N-Acetyl-DL-alanine.
HY-143918S

4'-Hydroxy Atomoxetine-d3 hemioxalate

4'-Hydroxy Atomoxetine-d3 (hemioxalate) 是 4'-Hydroxy Atomoxetine氘代物。
HY-B0311CS

(Rac)-Carbidopa-13C,d3

(Rac)-Carbidopa-13C,d3 is the 13C- and deuterium labeled.
HY-136655S

(S)-Apomorphine-13C,d3 hydrochloride

(S)-Apomorphine-13C,d3 (hydrochloride) is the 13C- and deuterium labeled.

HY-14274S1

Anastrozole-d3 Dimer Impurity	Aromatase	Cancer
Anastrozole-d3 Dimer Impurity is the deuterium labeled Anastrozole. Anastrozole is a potent, highly selective aromatase inhibitor, which inhibits human placental aromatase with an IC₅₀ of 15 nM.

HY-113493S1

4-Pyridoxic acid-d3	Endogenous Metabolite	Metabolic Disease
4-Pyridoxic acid-d3 is the deuterium labeled 4-Pyridoxic acid. 4-Pyridoxic acid is a catabolic product of vitamin B6 which is excreted in the urine.

HY-N0325S3

DL-Methionine-d3	Parasite
DL-Methionine-d3 is the deuterium labeled DL-Methionine. DL-Methionine is an essential amino acid containing sulfur with oxidative stress defense effects. DL-Methionine can be used for animal natural feed. DL-Methionine also kills H. rostochiensis on potato plants.

HY-B1374S

ent-Florfenicol-d3	Bacterial Antibiotic	Infection
ent-Florfenicol-d3 is the deuterium labeled Florfenicol. Florfenicol, a commonly used veterinary antibiotic, is currently indicated for the treatment of bovine respiratory disease, and also used in aquaculture for the control of enteric septicemia in catfish. Florfenicol can induce early embryonic death in eggs, with an LC50 of 1.07 μg/g.

HY-130569S

7-Hydroxymethotrexate-d3 sodium	Drug Metabolite	Cancer Inflammation/Immunology
7-Hydroxymethotrexate-d3 (sodium) is deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.

HY-66008S1

N-Acetyl mesalazine-d3-1

N-Acetyl mesalazine-d3-1 is deuterium labeled 5-acetamido-2-hydroxybenzoic acid.
HY-33549S

DL-Metirosine-13C,d3 hydrochloride

DL-Metirosine-13C,d3 (hydrochloride) is deuterium labeled α-Methyl-p-tyrosine.

HY-113202S

Stearoyl-L-carnitine-d3	Endogenous Metabolite	Metabolic Disease Neurological Disease
Stearoyl-L-carnitine-d3 is the deuterium labeled Stearoylcarnitine. Stearoylcarnitine, a fatty ester lipid molecule, is a human endogenous metabolite. Stearoylcarnitine acts as a metabolomics biomarker for early-onset-preeclampsia and late-onset-preeclampsia.

HY-136438S

Toltrazuril sulfoxide-d3	Endogenous Metabolite Parasite	Metabolic Disease Inflammation/Immunology
rac Toltrazuril-d3 Sulfoxide is the deuterium labeled Toltrazuril sulfoxide. Toltrazuril sulfoxide is a short-lived intermediary metabolite of Toltrazuril (HY-B0175), and then can be metabolized to the reactive toltrazuril sulfone (TZR-SO2) in vivo. Toltrazuril is an antiprotozoal agent that acts upon Coccidia parasites.

HY-N0830S5

Palmitic acid-d3	HSP Endogenous Metabolite	Metabolic Disease Neurological Disease Cardiovascular Disease Cancer
Palmitic acid-d3 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.

HY-13317S

Oseltamivir-d3	Influenza Virus	Infection
Oseltamivir D3 is a deuterium labeled Oseltamivir. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent.

HY-B0091S

Adapalene-d3	RAR/RXR Autophagy Apoptosis	Cancer Inflammation/Immunology Neurological Disease
Adapalene-d3 is the deuterium labeled Adapalene. Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC₅₀s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity.

HY-W012791S

2-(Methylamino)acetic acid-d3 hydrochloride

2-(Methylamino)acetic acid-d3 hydrochloride is the deuterium labeled 2-(Methylamino)acetic acid.

HY-12715S

Yohimbine-13C,d3	Adrenergic Receptor	Neurological Disease Endocrinology
Yohimbine-13C,d3 is the 13C- and deuterium labeled Yohimbine. Yohimbine is a potent and relatively nonselective alpha 2-adrenergic receptor (AR) antagonist, with IC₅₀ of 0.6 μM.

HY-10582S2

Flurbiprofen-13C,d3 dl-Flurbiprofen-13C,D3	COX Apoptosis	Inflammation/Immunology Cancer
Flurbiprofen-13C,d3 is the 13C- and deuterium labeled. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer.

HY-12651S

Primaquine-d3 diphosphate	Parasite	Infection
Primaquine-d3 diphosphate is the deuterium labeled Primaquine diphosphate. Primaquine Diphosphate (Primaquine phosphate), an 8-aminoquinoline, exerts a broad spectrum of activities against various stages of parasitic malaria. Primaquine Diphosphate remains as the only agent that destroys late hepatic stages and latent tissue forms of Plasmodium vivax and Plasmodium ovale.

HY-15234S

Fluticasone furoate-d3	Glucocorticoid Receptor	Inflammation/Immunology
Fluticasone furoate-d3 is deuterium labeled Fluticasone furoate. Fluticasone furoate is a topical, intranasal, enhanced-affinity synthetic trifluorinated corticosteroid with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflamatory and anti-asthmatic activity, and low systemic exposure. Fluticasone furoate has the potential for allergic rhinitis treatment.

HY-113147AS

L-Palmitoylcarnitine-d3 hydrochloride	Potassium Channel Endogenous Metabolite	Metabolic Disease Cardiovascular Disease
L-Palmitoylcarnitine-d3 hydrochloride is the deuterium labeled L-Palmitoylcarnitine hydrochloride. L-Palmitoylcarnitine hydrochloride, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine hydrochloride inhibits K_ATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2.

HY-132352S1

(Rac)-4-Hydroxy Duloxetine-d3

(Rac)-4-Hydroxy Duloxetine-d3 是 (Rac)-4-Hydroxy Duloxetine氘代物。

HY-A0125AS

Alizapride-13C,d3 hydrochloride	Dopamine Receptor	Cancer Neurological Disease
Alizapride-13C,d3 (hydrochloride) is deuterium labeled Alizapride (hydrochloride). Alizapride hydrochloride is a dopamine receptor antagonist with prokinetic and antiemetic effects which can also be used in the treatment of nausea and vomiting, including postoperative nausea and vomiting.

HY-133695S

ent-Florfenicol Amine-d3	Antibiotic	Infection
ent-Florfenicol Amine-d3 is the deuterium labeled Florfenicol amine. Florfenicol amine is a metabolite of Florfenicol (HY-B1374). Florfenicol, a veterinary antibiotic, can be used in aquaculture to control susceptible bacterial diseases.

HY-W010589S

H-Abu-OH-d3	Endogenous Metabolite	Metabolic Disease
H-Abu-OH-d3 is the deuterium labeled H-Abu-OH. H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.

HY-50904S1

Nintedanib-13C,d3 BIBF 1120-13C,D3	PDGFR VEGFR FGFR	Cancer
Nintedanib-13C,d3 is the 13C- and deuterium labeled. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

HY-B1455S

Clindamycin-d3 hydrochloride	Bacterial Antibiotic	Infection
Clindamycin-d3 hydrochloride is the deuterium labeled Clindamycin. Clindamycin is an oral protein synthesis inhibitory agent that has the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla).

HY-135096

Amitriptyline-d3 hydrochloride	Serotonin Transporter 5-HT Receptor Histamine Receptor mAChR Adrenergic Receptor Sodium Channel Trk Receptor	Neurological Disease
Amitriptyline-d3 hydrochloride is the deuterium labeled Amitriptyline (hydrochloride). Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with K_is of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a K_i of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity.

HY-B0965AS

Thioridazine-d3 hydrochloride	Dopamine Receptor Apoptosis 5-HT Receptor Autophagy Bacterial	Neurological Disease
Thioridazine-d3 hydrochloride is the deuterium labeled Thioridazine. Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of *PI3K-Akt-mTOR* signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs).

HY-13676S

Megestrol acetate-d3	Progesterone Receptor Autophagy HIV	Endocrinology Cancer
Megestrol acetate-d3 is the deuterium labeled Megestrol acetate. Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway.

HY-120504S

N-Acetyltyramine-d3	Bacterial	Cancer Infection
N-Acetyltyramine-d3 is the deuterium labeled N-Acetyltyramine. N-Acetyltyramine is a quorum-sensing inhibitor (QSI) compound produced by V. alginolyticus M3-10. N-Acetyltyramine is capable of inhibiting the QS of C. violaceum ATCC 12472. N-acetyltyramine reverses resistance in Doxorubicin-resistant leukemia P388 cells.

HY-B0377S

Famotidine-13C,d3	Histamine Receptor	Metabolic Disease Endocrinology
Famotidine-13C,d3 is the 13C- and deuterium labeled. Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.

HY-10331S1

Regorafenib-13C,d3 BAY 73-4506-13C,D3	VEGFR Autophagy PDGFR Raf RET	Cancer
Regorafenib-13C,d3 is the 13C- and deuterium labeled. Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1, respectively.

HY-B0708S

β-Estradiol 17-acetate-d3 1,3,5(10)-Estratriene-3,17β-diol 17-acetate-D3	Estrogen Receptor/ERR	Endocrinology
β-Estradiol 17-acetate-d3 (1,3,5(10)-Estratriene-3,17β-diol 17-acetate-d3) is the deuterium labeled β-Estradiol 17-acetate. β-Estradiol 17-acetate is a metabolite of estradiol.

HY-132392S

L-DOPA-2,5,6-d3	Dopamine Receptor Endogenous Metabolite	Neurological Disease
L-DOPA-2,5,6-d3 (Levodopa-2,5,6-d3) is the deuterium labeled L-DOPA. L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain.

HY-137813S

PERK-IN-4-d3	PERK	Cancer Metabolic Disease Neurological Disease
PERK-IN-4-d3 is the deuterium labeled PERK-IN-4. PERK-IN-4 is a potent and selective PERK (protein kinase R (PKR)-like endoplasmic reticulum kinase) inhibitor with an IC ₅₀ of 0.3 nM. PERK is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states.

HY-W041895S1

DL-Glutamic acid-d3	Endogenous Metabolite	Others
DL-Glutamic acid-d3 is the deuterium labeled DL-Glutamic acid. DL-Glutamic acid is the conjugate acid of Glutamic acid, which acts as a fundamental metabolite. Comparing with the second phase of polymorphs α and β L-Glutamic acid, DL-Glutamic acid presents better stability.

HY-126061S

1,7-Dimethyluric acid-d3	Endogenous Metabolite	Neurological Disease
1,7-Dimethyluric acid-d3 is the deuterium labeled 1,7-Dimethyluric acid. 1,7-Dimethyluric acid is the metabolite of caffeine.

HY-108485S

Damnacanthal-d3	Src Apoptosis Fungal	Cancer Infection Inflammation/Immunology
Damnacanthal-d3 is the deuterium labeled Damnacanthal. Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56^lck tyrosine kinase activity. Natural Damnacanthal inhibits p56 ^lck autophosphorylation and phosphorylation of exogenous substrates with IC₅₀s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity against Candida albicans.

HY-B0524AS1

Betahistine-13C,d3 dihydrochloride	Histamine Receptor	Endocrinology Inflammation/Immunology Neurological Disease
Betahistine-13C,d3 (dihydrochloride) is the 13C- and deuterium labeled. Betahistine dihydrochloride is an orally active histamine H1 receptor agonist and a H3 receptor antagonist. Betahistine dihydrochloride is used for the study of rheumatoid arthritis (RA).

HY-N2362S2

DL-Alanine-d3 DL-2-Aminopropionic acid-D3	Endogenous Metabolite	Metabolic Disease
DL-Alanine-d3 is the deuterium labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver.

HY-14608S8

L-Glutamic acid-d3	Endogenous Metabolite iGluR Ferroptosis Apoptosis	Neurological Disease
L-Glutamic acid-d3 is the deuterium labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-B0261S2

Meloxicam-13C,d3	COX Autophagy Apoptosis	Inflammation/Immunology Cancer
Meloxicam-13C,d3 is deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.

HY-13715S

(Rac)-Norepinephrine-d3 (formate)	Endogenous Metabolite Adrenergic Receptor Autophagy	Endocrinology Cardiovascular Disease
(Rac)-Norepinephrine-d3 (formate) is deuterium labeled Norepinephrine. Norepinephrine (Levarterenol; L-Noradrenaline) is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors.

HY-B0640S

Epinastine-13C,d3 hydrobromide WAL801-13C,D3 hydrobromide	Histamine Receptor	Inflammation/Immunology Endocrinology
Epinastine-13C,d3 (hydrobromide) is the 13C- and deuterium labeled. Epinastine (WAL801) is an antihistamine and mast cell stabilizer. Epinastine is a potent, selective and orally-active histamine H1 receptor antagonist. Epinastine also inhibits IL-8 release and has an antiallergic action.

HY-B0782S1

Acetazolamide-13C2,d3	Carbonic Anhydrase Autophagy	Cardiovascular Disease Cancer
Acetazolamide-13C2,d3 is the 13C- and deuterium labeled. Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Diuretic effects.

HY-123489S

*3α,21-Dihydroxy-5α-pregnan-20-one-d3* THDOC-D3	GABA Receptor	Neurological Disease
3α,21-Dihydroxy-5α-pregnan-20-one-d3 (THDOC-d3) is the deuterium labeled 3α,21-Dihydroxy-5α-pregnan-20-one. 3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABA_A receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABA_A receptors in vitro.

HY-130466S

Stearoyl-L-carnitine-d3 chloride	Endogenous Metabolite GlyT	Metabolic Disease
Stearoyl-L-carnitine-d3 chloride is the deuterium labeled Stearoyl-L-carnitine chloride. Stearoyl-L-carnitine chloride is an endogenous long-chain acylcarnitine. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2. Stearoyl-L-carnitine chloride inhibits glycine responses by 16.8% at concentrations up 3 μM.

HY-111614S2

Melengestrol acetate-d3	Progesterone Receptor	Cancer Metabolic Disease
Melengestrol acetate-d3 is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research.

HY-143925S

Betahistine impurity 5-13C,d3

Betahistine impurity 5-13C,d3 is the 13C- and deuterium labeled.

HY-W001179S

2,5-Dihydroxybenzoic acid-d3	Endogenous Metabolite FGFR	Others
2,5-Dihydroxybenzoic acid-d3 is the deuterium labeled 2,5-Dihydroxybenzoic acid. 2,5-Dihydroxybenzoic acid is a derivative of benzoic and a powerful inhibitor of fibroblast growth factors.

HY-15992S

BIBF 1202-13C,d3	VEGFR	Cancer
BIBF 1202-13C,d3 is the 13C- and deuterium labeled. BIBF 1202 is the carboxylate metabolite of BIBF 1120 which inhibits VEGFR2 kinase with an IC50 of 62 nM.

HY-B0462AS

Azelastine-13C,d3	Histamine Receptor SARS-CoV	Infection Endocrinology Metabolic Disease Inflammation/Immunology
Azelastine-13C,d3 is deuterium labeled Azelastine. Azelastine, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2.

HY-143939S

DL-Glutaryl carnitine-13C,d3

DL-Glutaryl carnitine-13C,d3 is the 13C- and deuterium labeled.
HY-139517S1

N-Desethyl etifoxine--13C,d3

N-Desethyl etifoxine--13C,d3 is the 13C- and deuterium labeled.

HY-32350S

Ercalcitriol-13C,d3 1α,25-Dihydroxy Vitamin D2-13C,D3	VD/VDR Drug Metabolite Endogenous Metabolite	Metabolic Disease
Ercalcitriol-13C,d3 is the 13C- and deuterium labeled. Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2.

HY-B1658BS

Frovatriptan-d3 succinate (R)-Frovatriptan-D3 succinate; SB 209509-D3 succinate; VML 251-D3 succinate	5-HT Receptor	Neurological Disease
Frovatriptan-d3 (succinate) is deuterium labeled Frovatriptan (succinate). Frovatriptan succinate ((R)-Frovatriptan succinate) is a potent, high affinity, selective and orally active 5-HT1B (pK50 of 8.2) and 5-HT1D receptor agonist. Frovatriptan succinate exhibits >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7 and >1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptor. Frovatriptan succinate has the potential for migraine research.

HY-143966S

5-Hydroxy Indapamide-13C,d3

5-Hydroxy Indapamide-13C,d3 is the 13C- and deuterium labeled.

HY-113524S

N-Acetyl-L-aspartic acid-d3	Endogenous Metabolite	Others
N-Acetyl-L-aspartic acid-d3 is the deuterium labeled N-Acetyl-L-aspartic acid. N-Acetyl-L-aspartic acid is a derivative of aspartic acid.

HY-W009418S

1-Methylnicotinamide-13C,d3 iodide

1-Methylnicotinamide-13C,d3 (iodide) is the 13C- and deuterium labeled.
HY-111660S1

3-Methoxytyramine sulfate-13C,d3

3-Methoxytyramine sulfate-13C,d3 is deuterium labeled 3-Methoxytyramine sulfate.

HY-N0326S2

L-Methionine-13C,d3	Endogenous Metabolite	Others
L-Methionine-13C,d3 is the 13C- and deuterium labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.

HY-W017007S

*3-Methyl-L-histidine-d3*	Endogenous Metabolite	Metabolic Disease
3-Methyl-L-histidine-d3 is the deuterium labeled 3-Methyl-L-histidine. 3-Methyl-L-histidine is a biomarker for meat consumption, especially chicken. It is also a biomarker for the consumption of soy products.

HY-B0316S

Avobenzone-13C,d3	Estrogen Receptor/ERR Apoptosis	Others
Avobenzone-13C,d3 is the 13C- and deuterium labeled. Avobenzone, a dibenzoylmethane compound, is one of the most widely used filters in sunscreens for skin photoprotection in the UVA band. Avobenzone is an endocrine disruptor that directly binds to estrogen receptor β and acts as an estrogen agonist.

HY-W012382S

N-Acetyl-L-tyrosine-d3	Endogenous Metabolite
N-Acetyl-L-tyrosine-d3 is the deuterium labeled N-Acetyl-L-tyrosine. N-Acetyl-L-tyrosine originates from tyrosine through an AA acetylase, is associated with aromatic L-amino acid decarboxylase deficiency and tyrosinemia I.

HY-W017006S

1-Methyl-L-histidine-d3	Endogenous Metabolite	Metabolic Disease
1-Methyl-L-histidine-d3 is the deuterium labeled 1-Methyl-L-histidine. 1-Methyl-L-histidine is an objective indicator of meat ingestion and exogenous 3-methylhistidine (3MH) intake.

HY-103552S

LY487379-d3 hydrochloride	mGluR	Neurological Disease
LY487379-d3 hydrochloride is the deuterium labeled LY487379 hydrochloride. LY487379 hydrochloride is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 hydrochloride potentiates glutamate-stimulated [³⁵S]GTPγS binding with EC₅₀ values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 hydrochloride promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 hydrochloride can be used for schizophrenia research.

HY-B1278S

D-α-Tocopherol acetate-d3	Endogenous Metabolite	Metabolic Disease Cancer
D-α-Tocopherol acetate-d3 is the deuterium labeled D-α-Tocopherol acetate. D-α-Tocopherol acetate (D-Vitamin E acetate) can be hydrolyzed to d-alpha-tocopherol (VE) and absorbed in the small intestine.

HY-W008719S

MPP+-d3(iodide)	Mitochondrial Metabolism	Neurological Disease
MPP+-d3(iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT).

HY-10053S1

Maropitant-13C,d3	Neurokinin Receptor	Neurological Disease Endocrinology
Maropitant-13C,d3 is the 13C- and deuterium labeled. Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting.

HY-N0180S

18β-Glycyrrhetinic acid-d3	Endogenous Metabolite	Cancer Inflammation/Immunology
18β-Glycyrrhetinic acid-d3 is deuterium labeled 18β-Glycyrrhetinic acid. 18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.

HY-113248S

*3-Nitro-L-tyrosine-d3*	Endogenous Metabolite	Metabolic Disease
3-Nitro-L-tyrosine-d3 is the deuterium labeled 3-Nitro-L-tyrosine. 3-Nitro-L-tyrosine is a biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions.

HY-W206016S

3-Amino-2-hydroxybenzoic acid-d3

3-Amino-2-hydroxybenzoic acid-d3 is deuterium labeled 3-Amino-2-hydroxybenzoic acid.

HY-16973S

Fluralaner-13C2,15N,d3 A1443-13C2,15N,D3; AH252723-13C2,15N,D3	Parasite	Infection
Fluralaner-13C2,15N,d3 is the deuterium, 13C-, and 15-labeled Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.

HY-W010037S

2-(tert-Butyl)-4-methoxyphenol-d3
Endogenous Metabolite

2-(tert-Butyl)-4-methoxyphenol-d3 is deuterium labeled 2-(tert-Butyl)-4-methoxyphenol.
HY-W024365S

2-tert-Butyl-4-hydroxyanisole-d3

2-tert-Butyl-4-hydroxyanisole-d3 is deuterium labeled 3-tert-Butyl-4-methoxyphenol.

HY-B0702S

Nicergoline-13C,d3	Adrenergic Receptor	Neurological Disease Cardiovascular Disease
Nicergoline-13C,d3 is the 13C- and deuterium labeled. Nicergoline, an ergoline derivative ester of bromonicotinic acid, is a potent, selective and orally active antagonist of α1A-adrenoceptor. Nicergoline has vasodilator effects. Nicergoline also has ameliorative effects on cognitive function in mouse models of Alzheimer's disease.

HY-10531S

ARRY-380 analog-d3	EGFR	Cancer
ARRY-380 analog-d3 is the deuterium labeled ARRY-380 analog. ARRY-380 analog, an inhibitor of EGFR (ErbB1), is extracted from patent WO2015153959A2, compound 249. ARRY-380 is a potent, selective, ATP-competitive, orally active inhibitor of HER2.

HY-108411S

Emedastine-13C,d3 fumarate	Histamine Receptor	Inflammation/Immunology
Emedastine-13C,d3 (fumarate) is the 13C- and deuterium labeled. Emedastine is an orally active, selective and high affinity histamine H1 receptor antagonist with a Ki value of 1.3 nM. Emedastine is a benzimidazole derivative with potent antiallergic properties and used for allergic rhinitis, allergic skin diseases and allergic conjunctivitis.

HY-13676S1

Megestrol acetate-d3-1	Progesterone Receptor Autophagy HIV	Endocrinology Cancer
Megestrol acetate-d3-1 is deuterium labeled Megestrol acetate. Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway.

HY-B0612AS1

Lercanidipine-13C,d3-1 hydrochloride	Calcium Channel	Cardiovascular Disease
Lercanidipine-13C,d3-1 (hydrochloride) is deuterium labeled Lercanidipine (hydrochloride). Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect.

HY-B0949S

Protriptyline (N-methyl-d3) (hydrochloride)	AChE	Neurological Disease
Protriptyline (N-Methyl-d3) hydrochloride is the deuterium labeled Protriptyline hydrochloride. Protriptyline hydrochloride is a tricyclic antidepressant (TCA), specifically a secondary amine, for the treatment of depression and ADHD. Unique among the TCAs, protriptyline tends to be energizing instead of sedating, used for narcolepsy to achieve a wakefulness-promoting effect.

HY-113068S

β-Tocopherol-d3	Tyrosinase	Metabolic Disease
β-Tocopherol-d3 is the deuterium labeled β-Tocopherol. β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol can also prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol.

HY-B0262S2

Methocarbamol-13C,d3	Sodium Channel	Neurological Disease
Methocarbamol-13C,d3 is the 13C- and deuterium labeled. Methocarbamol is an orally active central muscle relaxant and blocks muscular Nav1.4 channel. Methocarbamol reversibly affects voltage dependence of inactivation of Nav1.4 channel. Methocarbamol has the potential for muscle spasms and pain syndromes research.

HY-B0220S1

Erythromycin-13C,d3	Bacterial Antibiotic	Infection
Erythromycin-13C,d3 is the 13C- and deuterium labeled Erythromycin. Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid.

HY-N0168AS1

(Rac)-Hesperetin-13C,d3	p38 MAPK Apoptosis Autophagy	Cancer Neurological Disease
(Rac)-Hesperetin-13C,d3 is the 13C- and deuterium labeled. (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.

HY-W017443S3

L-Asparagine-15N2,d3 monohydrate	Endogenous Metabolite	Metabolic Disease
L-Asparagine-15N2,d3 monohydrate is the deuterium and 15N-labeled L-Asparagine monohydrate. L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-143967S

Iloperidone metabolite P95-13C,d3

Iloperidone metabolite P95-13C,d3 is the 13C- and deuterium labeled.

HY-N0666S9

L-Aspartic acid-15N,d3	Endogenous Metabolite	Cardiovascular Disease
L-Aspartic acid-15N,d3 is the deuterium and 15N-labeled L-Aspartic acid. L-Aspartic acid is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.

HY-32351AS

Calcifediol-d6 monohydrate 25-hydroxy Vitamin D3-d6 monohydrate	VD/VDR Endogenous Metabolite	Metabolic Disease
Calcifediol-d6 (25-hydroxy Vitamin D3-d6) monohydrate is the deuterium labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), a major circulating metabolite of vitamin D3, is a potent VDR inhibitor.

HY-N7265S

Epi-galanthamine-O-methyl-d3	AChE	Neurological Disease
Epi-galanthamine-O-methyl-d3 is the deuterium labeled Epi-galantamine. Epi-galantamine is a diastereomer of Galantamine. Epi-galantamine is an alkaloid isolated from the bulbs and flowers of Caucasian snowdrop (Galanthus woronowii). Epi-galantamine inhibits AChE with an EC₅₀ of 45.7 μM.

HY-132337S

Galanthamine N-Oxide-d3	AChE	Neurological Disease
Galanthamine N-Oxide-d3 is the deuterium labeled Galanthamine N-Oxide. Galanthamine N-Oxide is an alkaloid obtained from the bulbs of Zephyranthes concolor. Galanthamine N-Oxide inhibits electric eel acetylcholinesterase (AChE) with an EC₅₀ of 26.2 μM. Galanthamine N-Oxide is a prominent inhibitor of substrate accommodation in the active site of the Torpedo californica AChE (TcAChE), hAChE and hBChE enzymes.

HY-B0847S1

Propiconazole-d3 nitrate	Fungal Reactive Oxygen Species	Infection
Propiconazole-d3 nitrate is the deuterium labeled Propiconazole nitrate. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits *S. cerevisiae, but not rat liver, microsomal cytochrome P450* (IC₅₀s=0.04 and >200 µM, respectively). Propiconazole inhibits the growth of *T. deformans* and *R. stolonifer* (ED₅₀s=0.073 and 4.6 µg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS).

HY-103005S

Ramelteon metabolite M-II-d3	Melatonin Receptor Drug Metabolite	Neurological Disease Endocrinology
Ramelteon metabolite M-II-d3 is the deuterium labeled Ramelteon metabolite M-II. Ramelteon metabolite M-II is the major metabolite of Ramelteon, with IC₅₀s of 208 pM, 1470 pM for human melatonin receptors (MT₁ or MT₂). Ramelteon is a selective melatonin agonist.

HY-10366

BI-78D3
JNK Metabolic Disease Cancer

BI-78D3 functions as a substrate competitive inhibitor of JNK, inhibit the JNK kinase activity (IC₅₀=280 nM).

HY-B0520AS

Benztropine-13C,d3 mesylate	Dopamine Receptor mAChR Histamine Receptor	Cancer Neurological Disease
Benztropine-13C,d3 (mesylate) is the 13C- and deuterium labeled. Benztropine mesylate (Benzatropine mesylate) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects.

HY-135731AS

4-Methylamino antipyrine-d3 hydrochloride	COX Drug Metabolite	Inflammation/Immunology
4-Methylamino antipyrine-d3 (hydrochloride) is deuterium labeled 4-Methylamino antipyrine (hydrochloride). 4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic drug and can be used for pain and fever. 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties.

HY-Y0337S7

L-Cysteine-d3,15N	Endogenous Metabolite	Metabolic Disease
L-Cysteine-d3,15N is the deuterium and 15N-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans.

HY-133111S1

3-Hydroxy agomelatine-d3-1	5-HT Receptor	Neurological Disease
3-Hydroxy agomelatine-d3-1 is the deuterium labeled 3-Hydroxy agomelatine. 3-Hydroxy agomelatine is a metabolite of Agomelatine. 3-Hydroxy agomelatine is a 5-HT_2C receptor antagonist with an IC₅₀ of 3.2 μM and a K_i of 1.8 μM.

HY-B0619S1

Zaltoprofen-13C,d3	COX	Inflammation/Immunology
Zaltoprofen-13C,d3 is the 13C- and deuterium labeled. Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active COX-2 inhibitor, with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain.

HY-135111S

4-Desmethoxy Omeprazole-d3	Drug Metabolite	Cancer Infection Metabolic Disease
4-Desmethoxy Omeprazole-d3 is the deuterium labeled 4-Desmethoxy Omeprazole. 4-Desmethoxy Omeprazole is the active metabolite of Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a K_i of 2 to 6 μM. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria.

HY-W101495S1

Boc-Leu-OH·H2O-d3
Others

Boc-Leu-OH·H2O-d3 is the deuterium labeled Boc-Leu-OH·H2O.
HY-146656S

S-Sulfo-DL-cysteine-2,3,3-d3

S-Sulfo-DL-cysteine-2,3,3-d3 is the deuterium labeled S-Sulfo-DL-cysteine-2,3,3.

HY-12383S

Pelubiprofen-13C,d3	COX	Inflammation/Immunology Neurological Disease
Pelubiprofen-13C,d3 is the 13C- and deuterium labeled. Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects.

HY-113472S

N-Methyl-4-pyridone-3-carboxamide-d3

N-Methyl-4-pyridone-3-carboxamide-d3 is deuterium labeled N-Methyl-4-pyridone-3-carboxamide.

HY-Z0548S1

*Methyl 3,4-dihydroxybenzoate-d3-1*	Keap1-Nrf2 Apoptosis	Cancer Inflammation/Immunology
Methyl 3,4-dihydroxybenzoate-d3-1 is the deuterium labeled Methyl 3,4-dihydroxybenzoate. Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester; Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect.

HY-B0965S

Thioridazine-d3 2-Sulfone	Dopamine Receptor Apoptosis 5-HT Receptor Autophagy Bacterial	Cancer Infection Neurological Disease
Thioridazine-d3 2-Sulfone is the deuterium labeled Thioridazine hydrochloride. Thioridazine hydrochloride, an orally active antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine hydrochloride is also a potent inhibitor of *PI3K-Akt-mTOR* signaling pathways with anti-angiogenic effect. Thioridazine hydrochloride shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs).

HY-N1860S

*3-O-Methylquercetin-d3*	Phosphodiesterase (PDE)	Inflammation/Immunology
3-O-Methylquercetin-d3 is the deuterium labeled 3-O-Methylquercetin. 3-O-Methylquercetin (3-MQ), a main constituent of Rhamnus nakaharai, inhibits total cAMP and cGMP-phosphodiesterase (PDE) of guinea pig trachealis. 3-O-Methylquercetin (3-MQ) exhibits IC₅₀ values of 31.9 μM， 86.9 μM， 18.6 μM and 1.6 μM for PDE1, PDE5, PDE2 and PDE4, respectively.

HY-B1455S1

Clindamycin-13C,d3	Bacterial Antibiotic	Infection
Clindamycin-13C,d3 is the 13C- and deuterium labeled. Clindamycin is an oral protein synthesis inhibitory agent that has the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla).

HY-143921S

Almorexant (αS,1S) isomer-13C,d3

Almorexant (αS,1S) isomer-13C,d3 is the 13C- and deuterium labeled.

HY-B0410S

*Pramipexole (N-Propyl-3,3,3-d3) (dihydrochloride)*	Dopamine Receptor	Neurological Disease
Pramipexole (N-Propyl-3,3,3-d3) dihydrochloride is the deuterium labeled Pramipexole. Pramipexole is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with K_is of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D₂, D₃ and D₄ receptors, respectively. Pramipexole can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).

HY-10201S2

Sorafenib-13C,d3	Raf VEGFR FLT3 Autophagy Apoptosis Ferroptosis	Cancer
Sorafenib-13C,d3 is the 13C- and deuterium labeled Sorafenib. Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC₅₀s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC₅₀s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, *VEGFR3, PDGFRβ, FLT3* and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator.

HY-108226S

Regorafenib N-oxide and N-desmethyl (M5)-d3

Regorafenib N-oxide and N-desmethyl (M5)-d3 is deuterium labeled Regorafenib N-oxide and N-desmethyl (M5).

HY-113239S

*(3R,5S)-3-Hydroxy Cotinine-d3*	Endogenous Metabolite	Metabolic Disease
(3R,5S)-3-Hydroxy Cotinine-d3 is deuterium labeled Hydroxycotinine. Hydroxycotinine is the main nicotine metabolite detected in smokers urine.

HY-W016749S

N-Acetyl-DL-aspartic acid-2,3,3-d3

N-Acetyl-DL-aspartic acid-2,3,3-d3 is the deuterium labeled N-Acetyl-DL-aspartic acid-2,3,3.
HY-N8723S

(1′S,2′S)-Nicotine-1'-oxide-d3

(1′S,2′S)-Nicotine-1'-oxide-d3 is deuterium labeled (1′S,2′S)-Nicotine-1'-oxide.

HY-13292

Impurity B of Calcitriol 1β,25-Dihydroxyvitamin-D3; 1-Epicalcitriol	VD/VDR	Cancer
Impurity B of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-W055872S1

(9S)-9-Amino-9-deoxoerythromycin-13C,d3

(9S)-9-Amino-9-deoxoerythromycin-13C,d3 is the 13C- and deuterium labeled.

HY-N0771S6

L-Cysteine-13C3,15N,d3	Endogenous Metabolite	Others
L-Cysteine-13C3,15N,d3 is the deuterium, 13C-, and 15-labeled L-Isoleucine. L-isoleucine is a nonpolar hydrophobic amino acid. L-Isoleucine is an essential amino acid.

HY-Y1164S

D-Alanine-3,3,3-N-t-Boc-d3

D-Alanine-3,3,3-N-t-Boc-d3 is the deuterium labeled D-Alanine-3,3,3-N-t-Boc.

HY-W014663S

(S)-2-((tert-Butoxycarbonyl)amino)-3-hydroxypropanoic acid-d3
(S)-2-((tert-Butoxycarbonyl)amino)-3-hydroxypropanoic acid-d3 is the deuterium labeled (S)-2-((tert-Butoxycarbonyl)amino)-3-hydroxypropanoic acid.

HY-W017443S2

L-Asparagine-13C4,15N2,d3 monohydrate	Endogenous Metabolite	Metabolic Disease
L-Asparagine-13C4,15N2,d3 monohydrate is the deuterium, 13C-, and 15-labeled L-Asparagine monohydrate. L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.

HY-40136S

cis-4-Hydroxy-L-proline-d3	Endogenous Metabolite
cis-4-Hydroxy-L-proline-d3 is the deuterium labeled cis-4-Hydroxy-L-proline. cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer. cis-4-Hydroxy-L-proline also depresses the growth of primary N-nitrosomethylurea-induced rat mammary tumors.

HY-113103S

5β-Androstan-3α,17β-diol-d3

5β-Androstan-3α,17β-diol-d3 is the deuterium labeled 5β-Androstan-3α,17β-diol.

HY-N0666S5

L-Aspartic acid-13C4,15N,d3	Endogenous Metabolite	Cardiovascular Disease
L-Aspartic acid-13C4,15N,d3 is the deuterium, 13C-, and 15-labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.

HY-10002A

(1S)-Calcitriol 1α,25-Dihydroxy-3-epi-vitamin-D3	Others	Others
(1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D₃ (1α,25(OH)₂D₃). (1S)-Calcitriol exhibits potent vitamin D receptor (VDR)-mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion.

HY-15331

VD3-d6 Vitamin D3-26,26,26,27,27,27-d6	VD/VDR	Metabolic Disease
VD3-D6(Vitamin D3-26,26,26,27,27,27-d6) is the deuterated form of Vitamin D3; tools for determination of Vitamin D3 metabolites in human serum.

HY-I0678S1

Regorafénib N-oxyde (M2)-13C,d3	Drug Metabolite	Cancer
Regorafénib N-oxyde (M2)-13C,d3 is the 13C- and deuterium labeled. Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.

HY-13936S

2-(1-Methyl-1H-imidazol-4-yl)acetic acid-d3
Endogenous Metabolite

2-(1-Methyl-1H-imidazol-4-yl)acetic acid-d3 is deuterium labeled 2-(1-Methyl-1H-imidazol-4-yl)acetic acid.

HY-W168915S

*1-(3-Fluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid-d3*
1-(3-Fluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid-d3 is deuterium labeled 1-(3-Fluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid.

HY-138809

FAUC 346
Dopamine Receptor Neurological Disease

FAUC 346, a highly selective D₃ partial agonist (EC₅₀ = 1.5 nM), also demonstrates an inhibitory effect on cocaine-seeking behavior.
HY-139450

CDK4/6-IN-6
CDK Cancer

CDK4/6-IN-6 (example A94) is a potent CDK4/CDK6 inhibitor with a K_i of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.
HY-10002

Calcitriol
1,25-Dihydroxyvitamin D3
VD/VDR Endogenous Metabolite Cancer

Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.
HY-107218

11-Hydroxysugiol
RAR/RXR VD/VDR Infection

11-Hydroxysugiol regulates the SUMOylation of intracellular receptors by modulating RARα and vitamin D₃ receptor (VDR).

HY-10003

Alfacalcidol 1-hydroxycholecalciferol; 1.alpha.-Hydroxyvitamin D3	VD/VDR	Metabolic Disease
Alfacalcidol (1-hydroxycholecalciferol) is a vitamin D active metabolites, acts as a non-selective VDR activator medication, and widely be used in the management of osteoporosis.

HY-32343

Secalciferol (24R)-24,25-Dihydroxyvitamin D3	VD/VDR Endogenous Metabolite	Inflammation/Immunology
Secalciferol is a metabolite of Vitamin D, a possibly anti-inflammatory steroid which is involved in bone ossification.

HY-15029S1

(±)-Naproxen-d3-1
(Rac)-Naproxen D3 (α-methyl-D3)

HY-116020

FAUC 365	Dopamine Receptor	Neurological Disease
FAUC 365 is a highly dopamine D3 receptor-selective antagonist with K_i values of 0.5 nM, 340, 2600, and 3600 nM at D3, D4.4, D2_short, and D2_Long receptors, respectively. FAUC 365 can be used for the research of schizophrenia, and Parkinson's disease.

HY-14763S

Cariprazine-d6 RGH-188-d6	Dopamine Receptor 5-HT Receptor	Neurological Disease
Cariprazine D6 (RGH-188 D6) is a deuterium labeled Cariprazine. Cariprazine Cariprazine is an antipsychotic agent that exhibits high affinity for the D₃ (K_i of 0.085 nM) and D₂ (K_i of 0.49 nM) receptors, and moderate affinity for the 5-HT_1A receptor (K_i of 2.6 nM).

HY-100658

Didesmethyl cariprazine	5-HT Receptor Dopamine Receptor	Neurological Disease
Didesmethyl cariprazine is a metabolite of Cariprazine and acts as the predominant circulating active moiety. Didesmethyl cariprazine has a long half-life of 1-3 weeks. Cariprazine is a antipsychotic drug candidate that exhibits high affinity for the D₃ and D₂ receptors, and moderate affinity for the 5-HT_1A receptor.

HY-A0020

Eldecalcitol ED-71; 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3	VD/VDR	Metabolic Disease
Eldecalcitol (ED-71) is an orally active analogue of active vitamin D used in the treatment of osteoporosis. Eldecalcitol (ED-71) possesses a strong inhibitory effect on bone resorption and causes a significant increase in bone mineral density.

HY-12697A

NGB 2904 hydrochloride	Dopamine Receptor	Neurological Disease
NGB 2904 hydrochloride is a potent, selective, orally active and brain-penetrated antagonist of dopamine D3 receptor, with a K_i of 1.4 nM. NGB 2904 hydrochloride shows selectivity for D3 over D2, 5-HT2, α1, D4, D1 and D5 receptors (K_is=217, 223, 642, >5000, >10000 and >10000 nM, respectively). NGB 2904 hydrochloride antagonizes Quinpirole-stimulated mitogenesis. NGB 2904 hydrochloride can inhibit Cocaine's rewarding effects and Cocaine-induced reinstatement of drug-seeking behavior.

HY-130704

Isotachysterol 3	Calcium Channel	Metabolic Disease
Isotachysterol 3 is an analog of 1,25-dihydrox Vitamin D3. Isotachysterol 3 stimulates intestinal calcium transport and bone calcium mobilization in anephric rats.

HY-B0623A

Ropinirole hydrochloride SKF 101468 hydrochloride	Dopamine Receptor	Neurological Disease
Ropinirole (SKF 101468) hydrochloride is an orally active, potent D₃/D₂ receptor agonist with a K_i of 29 nM for D₂ receptor. Ropinirole hydrochloride has pEC₅₀s of 7.4, 8.4 and 6.8 for hD₂, hD₃ and hD₄ receptors, respectively. Ropinirole hydrochloride has no affinity for the D₁ receptors. Ropinirole hydrochloride has the potential for Parkinson's disease.

HY-B0623

Ropinirole SKF 101468	Dopamine Receptor	Neurological Disease
Ropinirole (SKF 101468) is an orally active, potent D₃/D₂ receptor agonist with a K_i of 29 nM for D₂ receptor. Ropinirole has pEC₅₀s of 7.4, 8.4 and 6.8 for hD₂, hD₃ and hD₄ receptors, respectively. Ropinirole has no affinity for the D₁ receptors. Ropinirole has the potential for Parkinson's disease.

HY-12398A

TEI-9648	VD/VDR	Metabolic Disease Inflammation/Immunology
TEI-9648, a Vitamin D₃ Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)₂D₃. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)₂D₃. TEI-9648 has the potential for bone metabolism research.

HY-B0094S

Artemisinin-d3
Qinghaosu-D3; NSC 369397-D3
HY-N4078S1

Hexanoic acid-d3
Hexylic acid-D3; Capronic acid-D3; Caproic acid-D3
HY-108506S

Licarbazepine-d3
BIA 2-005-D3; GP 47779-D3
Sodium Channel Neurological Disease

HY-15463S2

Imatinib-d3 hydrochloride STI571-D3 hydrochloride; CGP-57148B-D3 hydrochloride		Cancer
Imatinib(STI571) is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.

HY-12398

TEI-9647	VD/VDR	Metabolic Disease Inflammation/Immunology
TEI-9647, a Vitamin D₃ Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9647 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)₂D₃. TEI-9647 inhibits bone resorption and HL-60 cell differentiation induced by of 1α,25(OH)₂D₃. TEI-9647 has the potential for suppressing the excessive bone resorption and osteoclast formation in Paget's disease.

HY-79576S

NSC 88911-d3
Oestrone methyl ether-D3; 3-O-Methylestrone-D3
Others Cancer

HY-108907

SR-1277	Casein Kinase	Cancer
SR-1277 is a potent, selective and ATP competitive CK1δ/ε inhibitor, with IC₅₀s of 49 nM and 260 nM, respectively. SR-1277 also inhibits *FLT3, CDK4/cyclin D1, CDK6/cyclin D3* and CDK9/cyclin K, with IC₅₀s of 305 nM, 1340 nM, 311 nM and 109 nM, respectively. SR-1277 can be used for the research of cancer.

HY-118824S

N-Feruloylserotonin-d3
(E/Z)-Moschamine-D3
HY-138573S

N-Acetyl Adamantamine-d3
1-Acetamidoadamantane-D3
HY-12463S

Carmoterol-d3 hydrochloride
HY-119268S

Thiosildenafil-d3

HY-B0006S

Carvedilol-d3	Adrenergic Receptor Autophagy	Cancer Inflammation/Immunology Cardiovascular Disease
AA is the deuterium labeled Carvedilol. Carvedilol (BM 14190) is a non-selective β/α-1 blocker. Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC₅₀ of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure. Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome.

HY-B0019S

Azasetron-d3 hydrochloride
HY-135068

Butylone-d3 hydrochloride
HY-B1272AS1

Desipramine-d3
Others Metabolic Disease
HY-119536S

Norsufentanil-d3
HY-127165S

Velnacrine-d3
HY-110223

Atomoxetine-d3 hydrochloride
Adrenergic Receptor Neurological Disease
HY-A0274S

Ramosetron-d3 hydrochloride
HY-107469S

Pyridoxal-d3 hydrochloride
HY-132766S

Darexaban-d3 maleate
HY-113739S

Desmethylcitalopram-d3 hydrochloride
HY-121851S

Revaprazan-d3 hydrochloride
HY-127166S

Colchiceine-d3
HY-139509S

Capsiamide-d3
Others Neurological Disease
HY-127165S1

Velnacrine-d3 maleate
HY-106141S

Albaconazole-d3
HY-114524S

(E)-4-Oxo-2-nonenal-d3
4-ONE-D3
HY-132619S

5-Methylidene Rosiglitazone-d3
5-Methylidene BRL 49653-D3
HY-107494S1

13-cis-4-Oxoretinoic acid-d3
4-Keto 13-cis-retinoic acid-D3; 4-Oxoisotretinoin-D3

HY-15236S

PSI-6206 13C,d3 RO-2433 13C,D3; GS-331007 13C,D3; Sofosbuvir metabolite GS-331007 13C,D3	HCV	Infection
PSI-6206 13CD3 is the deuterium labeled PSI-6206. PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC₉₀ of >100 μM.

HY-50667S

Apixaban 13C,d3 BMS-562247-01 13C,D3	Factor Xa	Cardiovascular Disease
Apixaban 13CD3 (BMS-562247-01 13CD3) is a deuterium labeled Apixaban. Apixaban is a highly selective, reversible inhibitor of Factor Xa with K_i of 0.08 nM and 0.17 nM in human and rabbit, respectively.

HY-132667S

Methyl Flurbiprofen-d3
HY-B0661BS

(S)-Tamsulosin-d3 hydrochloride
HY-141780S

Demethyl Benzydamine-d3 hydrochloride
HY-Y1150S

Pivalic acid-d3
HY-W014728S

Deoxy Epinephrine-d3 hydrochloride
HY-131316S

Telmisartan-d3 methyl ester
HY-126182S2

Desacetyl Diltiazem-d3
HY-135371S

NMP-ACA-d3 chloride
HY-132799S

Desbenzene Ketoprofen-d3
HY-132627S

iso-Colchicine-d3
HY-113335S

Coprocholic acid-d3
HY-17622

Tavilermide
MIM-D3
Trk Receptor Inflammation/Immunology

Tavilermide is a selective, partial agonist of TrkA, or a nerve growth factor (NGF) mimetic.
HY-133991S

Desethyl Sildenafil-d3
HY-Y0896S

Methy-d3 (toluenesulfonate)
HY-132731S

Dehydro Ivabradine-d3
HY-13209BS

(Rac)-Ambrisentan-d3
HY-132657S

Dehydro Felodipine-d3
HY-134226S

Defluoro Levofloxacin-d3
HY-132681S

(Rac)-Cinacalcet-d3 hydrochloride
HY-B0661CS

(Rac)-Tamsulosin-d3 hydrochloride
HY-N1356AS

(R)-Reticuline-d3
HY-136907S

(S)-(-)-Verapamil-d3 hydrochloride

HY-76915

24, 25-Dihydroxy VD3	VD/VDR Endogenous Metabolite	Metabolic Disease
24, 25-Dihydroxy VD3 is a compound which is closely related to 1,25-dihydroxyvitamin D3, the active form of vitamin D3, but like vitamin D3 itself and 25-hydroxyvitamin D3 is inactive as a hormone both in vitro and in vivo.

HY-110000

(+)-PD 128907 hydrochloride	Dopamine Receptor	Neurological Disease
(+)-PD 128907 hydrochloride is a selective dopamine *D₂/D₃* receptor agonist, with K_is of 1.7, 0.84 nM for human and rat D₃ receptors, 179, 770 n M for human and rat D₃ receptors, respectively.

HY-W141742S

N-Despropyl Ropinirole-d3
HY-132750S

Decyclopentyl Zafirlukast-d3 Methyl Ester
HY-G0003AS

(S)-Hydroxy iloperidone-d3
HY-W072828S

4-Formyl antipyrine-d3
HY-I0294S

Alogliptin 6-chloro-d3
HY-W021266S

2-Demethyl Colchicine-d3
HY-132796S

(E)-N-Methylcinnamylamine-d3
HY-125904S

4-Hydroxyretinoic acid-d3
HY-66008S

N-Acetyl mesalazine-d3
HY-12651AS

Primaquine-13C,d3
HY-139392S

Octanoyl-L-carnitine-d3 chloride
HY-141750S

N-Desmethyl Zolmitriptan-d3 hydrochloride
HY-132685S

N-Desmethyl Topotecan-d3
HY-138112S

β-Dihydroequilin-d3
Others Neurological Disease
HY-124355S

4-Hydroxy hexenal-d3
HY-141791S

(±)-N-Desmethyl Trifluoroacetotramadol-d3
HY-132618S

N-Acetyltyramine Glucuronide-d3
Others Infection
HY-N7744S

α-Ergocryptine-d3
HY-128038S

N-Desmethyl-loperamide-d3
HY-133797S

Cyclobenzaprine N-oxide-d3
Others Metabolic Disease
HY-131495S

(Rac)-O-Desmethylnaproxen-d3
HY-132644S

3-Demethyl Thiocolchicine-d3
HY-139519S

N-Desmethyl diphenhydramine-d3 hydrochloride
Histamine Receptor Inflammation/Immunology
HY-131391S

m-Isobutyl Ibuprofen-d3
HY-132679S

(Rac)-Ambrisentan-d3 Methyl Ester
HY-Z3334S

N-Acetyl Sitagliptin-d3

HY-14545A

Amisulpride hydrochloride DAN 2163 hydrochloride	Dopamine Receptor	Neurological Disease
Amisulpride hydrochloride is a dopamine D₂/D₃ receptor antagonist with K_is of 2.8 and 3.2 nM for human dopamine D₂ and D₃, respectively.

HY-14545

Amisulpride DAN 2163	Dopamine Receptor	Cancer Neurological Disease
Amisulpride is a *dopamine D₂/D₃* receptor antagonist with K_is of 2.8 and 3.2 nM for human dopamine D₂** and D₃, respectively.

HY-U00185

A-437203 Lu201640; A37203	Dopamine Receptor	Neurological Disease
A-437203 is a selective D₃ receptor antagonist with K_i of 71, 1.6, and 6220 nM for D₂, D₃, and D₄ receptors, respectively.

HY-13294

Impurity C of Alfacalcidol	VD/VDR	Metabolic Disease
Impurity of Alfacalcidol. Alfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) is a non-selective VDR activator medication.

HY-76802

Calcitriol Derivatives
VD/VDR Metabolic Disease

Calcitriol Derivatives is a vitamin D3 analog.
HY-15267

MC 976
VD/VDR Metabolic Disease

MC 976 is a Vitamin D3 derivative.
HY-107494S

9-cis-4-Oxoretinoic acid-d3
4-Keto 9-cis-retinoic acid-D3

HY-103414

Raclopride	Dopamine Receptor	Neurological Disease
Raclopride is a dopamine D₂/D₃ receptor antagonist with potential antipsychotic effects. Raclopride binds to D₂ and D₃ receptors with K_is of 1.8 nM and 3.5 nM, respectively.

HY-13293

Impurity C of Calcitriol	VD/VDR	Cancer
Impurity C of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-14545S

Amisulpride-d5	Dopamine Receptor	Cancer Neurological Disease
Amisulpride-d5 is the deuterium labeled Amisulpride. Amisulpride is a *dopamine D₂/D₃* receptor antagonist with K_is of 2.8 and 3.2 nM for human dopamine D₂** and D₃, respectively.

HY-108976

Raclopride tartrate	Dopamine Receptor	Neurological Disease
Raclopride tartrate is a selective dopamine D₂/D₃ receptor antagonist with potential antipsychotic effects. Raclopride tartrate binds to D₂ and D₃ receptors with K_is of 1.8 nM and 3.5 nM, respectively.

HY-14545S1

Amisulpride-d5 N-Oxide	Dopamine Receptor	Cancer Neurological Disease
Amisulpride-d5 N-Oxide is the deuterium labeled Amisulpride. Amisulpride is a *dopamine D₂/D₃* receptor antagonist with K_is of 2.8 and 3.2 nM for human dopamine D₂** and D₃, respectively.

HY-113279

7-Dehydrocholesterol
Endogenous Metabolite Others

7-Dehydrocholesterol is biosynthetic precursor of cholesterol and vitamin D₃.
HY-15267B

(24S)-MC 976
VD/VDR Metabolic Disease

(24S)-MC 976 is a Vitamin D3 derivative.
HY-15267A

(24R)-MC 976
VD/VDR Metabolic Disease

(24R)-MC 976 is a Vitamin D3 derivative.

HY-76814

Calcitriol-d6	VD/VDR	Metabolic Disease
Calcitriol D6 is the deuterated form of Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ), which is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-32346

Atocalcitol
Others Inflammation/Immunology

Atocalcitol, a vitamin D3 analogue, is used in the study for psoriasis.
HY-B1752A

Quinpirole Hydrochloride
(-)-LY 171555
Dopamine Receptor Neurological Disease

Quinpirole Hydrochloride ((-)-LY 171555) is a high-affinity agonist of dopamine D2/D3 receptor.
HY-U00400

PF-592379
Dopamine Receptor Neurological Disease

PF-592379 is a potent dopamine D₃ receptor agonist with an EC₅₀ of 21 nM.
HY-B1196

Tiapride hydrochloride
Dopamine Receptor Neurological Disease

Tiapride hydrochloride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain.

HY-101382

GR 103691	Dopamine Receptor	Neurological Disease
GR 103691 is a potent, selective dopamine D₃ receptor antagonist with a K_i value of 0.4 nM. GR 103691 shows more than 100-fold selectivity for human dopamine human (h)D₃ over hD₄ and hD₁ sites.

HY-109150

Mesdopetam IRL790	Dopamine Receptor	Neurological Disease
Mesdopetam (IRL790) is a dopamine D3 receptor antagonist (K_i=90 nM; IC₅₀=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam is used for the research of motor and psychiatric complications in Parkinson disease.

HY-109150A

Mesdopetam hemitartrate IRL790 hemitartrate	Dopamine Receptor	Neurological Disease
Mesdopetam (IRL790) hemitartrate is a dopamine D3 receptor antagonist (K_i=90 nM; IC₅₀=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam hemitartrate is used for the research of motor and psychiatric complications in Parkinson disease.

HY-N0488S1

Vincristine-d3-ester sulfate Leurocristine-D3-ester sulfate; NSC-67574-D3-ester sulfate; 22-Oxovincaleukoblastine-D3-ester sulfate	Microtubule/Tubulin Apoptosis	Cancer
Vincristine-d3-ester (Leurocristine-d3-ester) sulfate is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a K_i of 85 nM .

HY-13284S

7-α-Methylthio Spironolactone-D3
Androgen Receptor Endocrinology
HY-141731S

4-Desmethoxy Omeprazole-d3 sulfide
HY-Z4206S

Deacetamidine Cyano Dabigatran-d3 Ethyl Ester
HY-A0115S

Ramiprilat-d3 (Mixture of Diastereomers)
HY-132722S

3α-Hydroxy Pravastatin-d3 sodium salt
HY-Y0787S

(E)-But-2-enal-d3
HY-141779S

5-O-Desmethyl Omeprazole-d3
HY-135663S

(Rac)-trans Jasmonic acid-d3
HY-N2374S

Eupatorin-d3 5-Methyl Ether
HY-15332

Alfacalcidol-d6
VD/VDR Metabolic Disease

Alfacalcidol-D6, a deuterated Alfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.
HY-19654

GSK598809
Dopamine Receptor Neurological Disease

GSK598809 is a potent and selective dopamine D3 Receptor (DRD3) antagonist, with a pK_i of 8.9.

HY-13332

Calcifediol-d6	VD/VDR	Metabolic Disease
Calcifediol-D6 is the deuterated form of Calcifediol(25-hydroxy Vitamin D3), which is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase IC50 value: Target: This metabolite is being measured by physicians worldwide to determine a patient's vitamin d status.

HY-10847

SB-277011 SB-277011A	Dopamine Receptor	Neurological Disease
SB-277011 is a potent and delective dopamine D3 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively); brain penetrant.

HY-32339

Maxacalcitol
22-Oxacalcitriol
VD/VDR Metabolic Disease

Maxacalcitol (22-Oxacalcitriol) is non-calcemic vitamin D3 analog and ligand of VDR-like receptors.
HY-103408

PG01037 dihydrochloride
Dopamine Receptor Neurological Disease

PG01037 (dihydrochloride) is a potent and selective dopamine D3 receptor antagonist with a K_i of 0.7 nM.

HY-103414S

Raclopride-d5 hydrochloride	Dopamine Receptor	Neurological Disease
Raclopride-d5 (hydrochloride) is the deuterium labeled Raclopride. Raclopride is a dopamine D₂/D₃ receptor antagonist, which binds to D₂ and D₃ receptors with dissociation constants (K_is) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D₁ and D₄ receptors with K_is of 18000 nM and 2400 nM, respectively.

HY-19654B

(-)-GSK598809
1S,5R-GSK598809
Dopamine Receptor Others

(-)-GSK598809 is an isomer of GSK598809. GSK598809 is a potent and selective dopamine D3 Receptor (DRD3) antagonist.

HY-12705A

Bromocriptine mesylate CB-154	Dopamine Receptor Autophagy	Neurological Disease Cancer
Bromocriptine mesylate is a potent *dopamine D2/D3* receptor agonist, which binds D2 dopamine receptor with pK_i** of 8.05±0.2.

HY-109162

Trazpiroben
TAK-906
Dopamine Receptor Neurological Disease

Trazpiroben (TAK-906) is a dopamine D2/D3 receptor antagonist used for chronic research of moderate-to-severe gastroparesis.

HY-114085

BP 897	Dopamine Receptor	Neurological Disease
BP 897 is a potent and partial dopamine D3 receptor agonist and a weak D2 receptor antagonist. BP 897 displays a high affinity at the dopamine D3 receptor (K_i=0.92 nM) and a 70 times lower affinity at the D2 receptor (K_i=61 nM). BP 897 exhibits selective inhibition of cocaine-seeking behavior.

HY-106660

BP 897 hydrochloride	Dopamine Receptor	Neurological Disease
BP 897 hydrochloride is a potent and partial dopamine D3 receptor agonist and a weak D2 receptor antagonist. BP 897 hydrochloride displays a high affinity at the dopamine D3 receptor (K_i=0.92 nM) and a 70 times lower affinity at the D2 receptor (K_i=61 nM). BP 897 exhibits selective inhibition of cocaine-seeking behavior.

HY-10847A

SB-277011 dihydrochloride SB-277011A dihydrochloride	Dopamine Receptor	Neurological Disease
SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D₃ receptor antagonist, with pK_is of 8.0, 6.0, <5.2 and 5.9 for D₃, D₂, 5-HT_1B, and 5-HT_1D receptors, respectively.

HY-19911

Pefcalcitol
SMD-502
Inflammation/Immunology

Pefcalcitol is a new antipsoriatic antedrug candidates having 16-en-22-oxa-vitamin D3 structures.

HY-103429

Quinelorane dihydrochloride LY163502	Dopamine Receptor	Neurological Disease
Quinelorane dihydrochloride (LY163502) is a potent *dopamine D3/D2* receptor** agonist. Quinelorane has the potential for neurological and psychiatric disorders research.

HY-19489S

(±)-Levomepromazine-d6 (±)-Methotrimeprazine-d6; dl-Methotrimeprazine-d6	Dopamine Receptor Histamine Receptor	Neurological Disease
(±)-Levomepromazine D6 ((±)-Methotrimeprazine D6) is the deuterium labeled Methotrimeprazine, which is a D3 dopamine and Histamine H1 receptor antagonist.

HY-A0007S

Rotigotine D7 Hydrochloride N-0923 D7 Hydrochloride	Dopamine Receptor	Neurological Disease
Rotigotine (N-0923) D7 Hydrochloride is the deuterium labeled Rotigotine(N-0923), which is a dopamine D2 and D3 receptor agonist.

HY-12697

NGB 2904	Dopamine Receptor	Neurological Disease
NGB 2904 is an orally active and selective dopamine (DA) D₃ receptor antagonist. NGB 2904 can be used for the research of cocaine addiction.

HY-70002S1

Enzalutamide-d6 MDV3100-d6	Androgen Receptor	Cancer
Enzalutamide D3 is a deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC₅₀ of 36 nM in LNCaP prostate cells.

HY-75041

Calcitriol Impurities A	VD/VDR	Metabolic Disease
Calcitriol Impurities A is the impurity of Calcitriol, Calcitriol is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-77274

Calcitriol Impurities D	VD/VDR	Metabolic Disease
Calcitriol Impurities D is the impurity of Calcitriol, Calcitriol is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-15329

Maxacalcitol-d6	VD/VDR	Metabolic Disease
Maxacalcitol-D6 is the deuterated form of Maxacalcitol (22-Oxacalcitriol), which is a non-calcemic vitamin D3 analog and VDR ligand of VDR-like receptors.

HY-132758S

Deacetamidine Cyano Dabigatran-d3 Ethyl Ester Oxalate
HY-141787S

4-Desmethoxy-4-bromo Trimethoprim-d3
HY-132743S

2-Descarboxy-2-cyano Telmisartan-d3
HY-107810S

Methyl 13-cis-4-oxoretinoate-d3
HY-132624S

(Rac)-N-Demethyl Dimethindene-d3 hydrobromide
HY-132800S

7-Methyl-3-methyluric acid-d3
HY-141774S

4,4-Dimethyl Retinoic acid-d3

HY-113279S

7-Dehydrocholesterol-d7	Endogenous Metabolite	Others
7-Dehydrocholesterol-d7 is the deuterium labeled 7-Dehydrocholesterol. 7-Dehydrocholesterol is biosynthetic precursor of cholesterol and vitamin D₃.

HY-P1083

Dynamin inhibitory peptide	Dynamin	Neurological Disease
Dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide blocks the dopamine D3 effect on GABAA receptors.

HY-10847B

SB-277011 hydrochloride SB-277011A hydrochloride	Dopamine Receptor 5-HT Receptor	Neurological Disease
SB-277011 hydrochloride (SB-277011A hydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D₃ receptor (D₃R) antagonist with K_i values of 10.7 nM and 11.2 nM at rodent and human D₃R, respectively. SB-277011 hydrochloride displays 80- to 100-fold selectivity over other dopamine receptors with pK_is of 8.0, 6.0, <5.2, and 5.9 for D3, D2, 5-HT_1B, and 5-HT_1D receptors, respectively.

HY-102089

Fluoroclebopride	Dopamine Receptor	Neurological Disease
Fluoroclebopride binds reversibly to dopamine receptors. ¹⁸F labeled fluoroclebopride has been used as a probe for studying D2/D3 receptor availability via PET in various monkey models.

HY-101348

L-741626	Dopamine Receptor	Neurological Disease
L-741626 is a selective D2 dopamine receptor antagonist, with the K_i values of 2.4, 100 and 220 nM for human D2, D3 and D4 receptors respectively.

HY-P1083A

Dynamin inhibitory peptide TFA	Dynamin	Neurological Disease
Dynamin inhibitory peptide TFA competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide TFA blocks the dopamine D₃ effect on GABA_A receptors.

HY-126068

(S)-Amisulpride Esamisulpride; SEP-4199	Dopamine Receptor 5-HT Receptor	Neurological Disease
(S)-Amisulpride (Esamisulpride) is a potent *dopamine D₂/D₃* receptor antagonist. (S)-Amisulpride is an antagonist at the 5-HT₇ receptor with a K_I** of 900 nM. (S)-Amisulpride has antipsychotic and antidepressant effects.

HY-136390

ML417	Dopamine Receptor	Neurological Disease
ML417 is a selective and brain penetrant D3 dopamine receptor (D3R) agonist, with an EC₅₀ of 38 nM. ML417 potently promotes D3R-mediated β-arrestin translocation, G protein mediated signaling, and pERK phosphorylation with minimal effects on other GPCR-mediated signaling. ML417 exhibits neuroprotection against toxin-induced neurodegeneration of dopaminergic neurons.

HY-15238A

ST-836 hydrochloride	Dopamine Receptor	Neurological Disease
ST-836 hydrochloride (compound 34) is a potent dopamine receptor ligand with K_i values of 4.5 nM, 132 nM for D3 and D2, respectively. ST-836 hydrochloride has the potential for Parkinson’s disease.

HY-32343S

Secalciferol-d6	VD/VDR Endogenous Metabolite	Inflammation/Immunology
Secalciferol-d6 ((24R)-24,25-Dihydroxyvitamin D3-d6) is the deuterium labeled Secalciferol. Secalciferol is a metabolite of Vitamin D, a possibly anti-inflammatory steroid which is involved in bone ossification.

HY-75041S

Calcitriol impurities A-d6	VD/VDR	Metabolic Disease
Calcitriol impurities A-d6 is the deuterium labeled Calcitriol Impurities A. Calcitriol Impurities A is the impurity of Calcitriol, Calcitriol is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-32344

Inecalcitol TX 522	VD/VDR Apoptosis	Cancer
Inecalcitol (TX 522), a unique vitamin D3 analog, is an orally active vitamin D receptor (VDR) agonist with a K_d of 0.53 nM. Inecalcitol can induce cell apoptosis and has potent anticancer activities.

HY-100219

CB1151
VD/VDR Cancer

CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 (VD) with potent anti-tumor effects. CB1151 inhibits MCF-7 cell growth with an IC₅₀ value of 0.82 nM.

HY-103406A

PNU-177864 hydrochloride	Dopamine Receptor	Neurological Disease
PNU-177864 hydrochloride is a potent, selective and orally active dopamine D₃ receptor antagonist. PNU-177864 hydrochloride is structurally consistent with a cationic amphiphilic drug (CAD) and induces phospholipidosis in vivo. PNU-177864 hydrochloride antischizophrenic activity.

HY-N0096

Rotundine (-)-Tetrahydropalmatine; L-Tetrahydropalmatine	5-HT Receptor Dopamine Receptor	Neurological Disease
Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC₅₀s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of 5-HT_1A with an IC₅₀ of 370 nM.

HY-116820

OS-3-106	Dopamine Receptor	Neurological Disease
OS-3-106 is a potent, BBB-penetrated and selective dopamine D3 receptor (D3R) agonist. OS-3-106 binds with high affinity (K_i = 0.2 nM) at the *D3R*. OS-3-106 reduces cocaine self-administration and sucrose reinforcement rates. OS-3-106 can be used for psychostimulant addiction research.

HY-107494S2

4-Oxoretinoic acid-d3
4-Keto retinoic acid
HY-141718S

N-Acetyl-S-(trichlorovinyl)-L-cysteine-d3

HY-146135

Tau-aggregation-IN-1	Microtubule/Tubulin Dopamine Receptor	Neurological Disease
Tau-aggregation-IN-1 (Compound D-519) is a tau441 protein aggregation inhibitor with an IC₅₀ of 21 µM. Tau-aggregation-IN-1 is also a dopamine D₂ and D₃ receptor agonist.

HY-14958A

Pardoprunox hydrochloride SLV-308 hydrochloride; DU-126891 hydrochloride	5-HT Receptor Adrenergic Receptor Dopamine Receptor	Neurological Disease Endocrinology
Pardoprunox (SLV-308) hydrochloride is a partial dopamine D2 and D3 receptor partial agonist and a serotonin 5-HT1A receptor agonist, with pEC₅₀s of 8, 9.2, and 6.3, respectively.

HY-14958

Pardoprunox SLV-308; DU-126891	5-HT Receptor Adrenergic Receptor Dopamine Receptor	Neurological Disease Endocrinology
Pardoprunox (SLV-308) is a partial dopamine D2 and D3 receptor partial agonist and a serotonin 5-HT1A receptor agonist, with pEC₅₀s of 8, 9.2, and 6.3, respectively.

HY-12697AS

NGB 2904-d8 hydrochloride	Dopamine Receptor	Neurological Disease
NGB 2904-d8 hydrochloride is the deuterium labeled NGB 2904 hydrochloride. NGB 2904 hydrochloride is a potent, selective, orally active and brain-penetrated antagonist of dopamine D3 receptor, with a K_i of 1.4 nM. NGB 2904 hydrochloride shows selectivity for D3 over D2, 5-HT2, α1, D4, D1 and D5 receptors (K_is=217, 223, 642, >5000, >10000 and >10000 nM, respectively). NGB 2904 hydrochloride antagonizes Quinpirole-stimulated mitogenesis. NGB 2904 hydrochloride can inhibit Cocaine's rewarding effects and Cocaine-induced reinstatement of drug-seeking behavior.

HY-14763A

Cariprazine hydrochloride RGH188 hydrochloride	Dopamine Receptor 5-HT Receptor	Neurological Disease
Cariprazine hydrochloride is a novel antipsychotic drug candidate that exhibits high affinity for the D₃ (K_i=0.085 nM) and D₂ (K_i=0.49 nM) receptors, and moderate affinity for the 5-HT_1A receptor (K_i=2.6 nM).

HY-14763

Cariprazine RGH-188	Dopamine Receptor 5-HT Receptor	Neurological Disease
Cariprazine is a novel antipsychotic drug candidate that exhibits high affinity for the D₃ (K_i=0.085 nM) and D₂ (K_i=0.49 nM) receptors, and moderate affinity for the 5-HT_1A receptor (K_i=2.6 nM).

HY-15296

Cabergoline FCE-21336	Dopamine Receptor Autophagy	Endocrinology
Cabergoline is an ergot derived-dopamine D₂-like receptor agonist that has high affinity for D₂, D₃, and 5-HT_2B receptors (K_i=0.7, 1.5, and 1.2, respectively).

HY-12987

Pimozide R6238	Dopamine Receptor Adrenergic Receptor STAT	Cancer Neurological Disease Endocrinology
Pimozide is a dopamine receptor antagonist, with K_is of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a K_i of 39 nM; Pimozide also inhibits *STAT3* and STAT5.

HY-A0077

Perphenazine	5-HT Receptor Adrenergic Receptor Dopamine Receptor Histamine Receptor	Neurological Disease Endocrinology
Perphenazine is a typical antipsychotic drug, inhibits *5-HT_2Areceptor, Alpha-1A adrenergic receptor, Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor, with K_i* values of 5.6, 10, 0.765/0.13, 3.4, and 8 nM, respectively.

HY-101641

NRA-0160	Dopamine Receptor 5-HT Receptor Adrenergic Receptor	Neurological Disease Endocrinology
NRA-0160 is a selective dopamine D4 receptor antagonist, with a K_i value of 0.48 nM and with negligible affinity for dopamine D2 receptor (K_i: >10000 nM), D3 receptor (K_i: 39 nM), rat 5-HT2A receptor (K_i: 180 nM) and rat α1 adrenoceptor (K_i: 237 nM).

HY-100656

Desmethyl cariprazine	Dopamine Receptor 5-HT Receptor Drug Metabolite	Neurological Disease
Desmethyl cariprazine is an active metabolite of Cariprazine. Cariprazine, an antipsychotic drug candidate, exhibits high affinity for the D3 (K_i=0.085 nM) and D2 (0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM).

HY-112023

Lumisterol 3 (>90%) 9β,10α-Cholesta-5,7-dien-3β-ol; Cholecalciferol EP Impurity A	Endogenous Metabolite	Others
Lumisterol 3 (>90%) (9β,10α-Cholesta-5,7-dien-3β-ol) is a normal human secosterooid metabolite from the class of vitamin D3 photoisomer derivatives. Lumisterol 3 (>90%) is used in the preparation of vitamin D.

HY-132620S

(Rac)-N-Desmethyl-N-(4-methoxyphenethyl) Venlafaxine-d3
HY-132677S

N,N’-Desethylene-N,N’-diformyl Levofloxacin-d3
HY-W010981S

Tributyl 2-acetoxypropane-1,2,3-tricarboxylate-d3
HY-132723S

17β-Estradiol-3-β-D-glucuronide-d3

HY-16567

Asenapine hydrochloride	5-HT Receptor Dopamine Receptor	Neurological Disease
Asenapine hydrochloride, an antipsychotic, is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and *Dopamine (D₂, D₃,* D₄) receptor antagonist with K_i** values of 0.03-4.0 nM for 5-HT and 1.3, 0.42, 1.1 nM for Dopamine receptor, respectively.

HY-139449

CDK4/6-IN-5	CDK	Cancer
CDK4/6-IN-5 is a potent CDK4 and CDK6 inhibitor with K_is of 0.2 and 4.4 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively. (from patent WO2019207463A1 example A93).

HY-15296S1

Cabergoline-d6 FCE-21336-d6	Dopamine Receptor Autophagy	Endocrinology
Cabergoline-d6 is deuterium labeled Cabergoline. Cabergoline is an ergot derived-dopamine D2-like receptor agonist that has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).

HY-14763S1

Cariprazine D8 RGH-188 D8	Dopamine Receptor 5-HT Receptor	Neurological Disease
Cariprazine D8 (RGH-188 D8) is a deuterium labeled Cariprazine. Cariprazine is a novel antipsychotic drug candidate that exhibits high affinity for the D₃ (K_i=0.085 nM) and D₂ (K_i=0.49 nM) receptors, and moderate affinity for the 5-HT_1A receptor (K_i=2.6 nM).

HY-N0636

Eriocitrin	Apoptosis	Cancer
Eriocitrin is a flavonoid isolated from lemon, which is a strong antioxidant agent. Eriocitrin could inhibit the proliferation of hepatocellular carcinoma cell lines by arresting cell cycle in S phase through up-regulation of p53, cyclin A, cyclin D3 and CDK6. Eriocitrin triggers apoptosis by activating mitochondria-involved intrinsic signaling pathway.

HY-14325

L-745870	Dopamine Receptor	Neurological Disease
L-745870 is a potent, selective, brain-penetrant and orally active dopamine D₄ receptor antagonist with a K_i of 0.43 nM. L-745870 shows weaker affinity for D₂ (K_i of 960 nM) and D₃ (K_i of 2300 nM) receptors, and exhibits moderate affinity for 5-HT₂ receptors, sigma sites and α-adrenoceptors.

HY-14325A

L-745870 trihydrochloride	Dopamine Receptor	Neurological Disease
L-745870 trihydrochloride is a potent, selective, brain-penetrant and orally active dopamine D₄ receptor antagonist with a K_i of 0.43 nM. L-745870 trihydrochloride shows weaker affinity for D₂ (K_i of 960 nM) and D₃ (K_i of 2300 nM) receptors, and exhibits moderate affinity for 5-HT₂ receptors, sigma sites and α-adrenoceptors.

HY-A0007

Rotigotine Hydrochloride N-0923 Hydrochloride	Dopamine Receptor Adrenergic Receptor 5-HT Receptor	Neurological Disease
Rotigotine Hydrochloride (N-0923 Hydrochloride) is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with K_i of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-14325B

L-745870 hydrochloride	Dopamine Receptor	Neurological Disease
L-745870 hydrochloride is a potent, selective, brain-penetrant and orally active dopamine D₄ receptor antagonist with a K_i of 0.43 nM. L-745870 hydrochloride shows weaker affinity for D₂ (K_i of 960 nM) and D₃ (K_i of 2300 nM) receptors, and exhibits moderate affinity for 5-HT₂ receptors, sigma sites and α-adrenoceptors.

HY-B0623AS

Ropinirole-d4 hydrochloride SKF 101468-d4 hydrochloride	Dopamine Receptor	Neurological Disease
Ropinirole-d4 (SKF 101468-d4) hydrochloride is the deuterium labeled Ropinirole hydrochloride. Ropinirole hydrochloride is a potent D₃/D₂ receptor agonist with a K_i of 29 nM for D₂ receptor. Ropinirole hydrochloride has pEC₅₀s of 7.4, 8.4 and 6.8 for hD₂, hD₃ and hD₄ receptors, respectively. Ropinirole hydrochloride has no affinity for the D₁ receptors. Ropinirole hydrochloride has the potential for Parkinson's disease.

HY-12987S1

Pimozide-d5 N-Oxide	Dopamine Receptor Adrenergic Receptor STAT	Cancer Neurological Disease Endocrinology
Pimozide-d5 N-Oxide is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with K_is of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a K_i of 39 nM; Pimozide also inhibits *STAT3* and STAT5.

HY-14763S2

Cariprazine-d6 hydrochloride RGH188-d6 hydrochloride	Dopamine Receptor 5-HT Receptor	Neurological Disease
Cariprazine-d6 (RGH188-d6) hydrochloride is the deuterium labeled Cariprazine hydrochloride. Cariprazine is a novel antipsychotic drug candidate that exhibits high affinity for the D₃ (K_i=0.085 nM) and D₂ (K_i=0.49 nM) receptors, and moderate affinity for the 5-HT_1A receptor (K_i=2.6 nM).

HY-75502

Rotigotine N-0437; N-0923	Dopamine Receptor Adrenergic Receptor 5-HT Receptor	Neurological Disease Endocrinology
Rotigotine (N-0437; N-0923) is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with K_is of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-15394

(Rac)-Rotigotine hydrochloride	Dopamine Receptor Adrenergic Receptor 5-HT Receptor	Endocrinology Neurological Disease
(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with K_is of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-12987S

Pimozide-d4 R6238-d4	Dopamine Receptor Adrenergic Receptor STAT	Cancer Endocrinology Neurological Disease
Pimozide D4 (R6238 D4) is a deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with K_is of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a K_i of 39 nM; Pimozide also inhibits *STAT3* and *STAT5*.

HY-132673S

(E/Z)-4,4’-Dihydroxy-N-desmethyl Tamoxifen-d3
HY-132647S

N-Desmethyl-4’-hydroxy Tamoxifen-d3 (E/Z Mixture)

HY-B0410A

Pramipexole dihydrochloride hydrate	Dopamine Receptor	Neurological Disease
Pramipexole dihydrochloride hydrate is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with K_is of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D₂, D₃ and D₄ receptors, respectively. Pramipexole dihydrochloride hydrate can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).

HY-B0410

Pramipexole	Dopamine Receptor	Neurological Disease
Pramipexole is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with K_is of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D₂, D₃ and D₄ receptors, respectively. Pramipexole can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).

HY-17355

Pramipexole dihydrochloride	Dopamine Receptor	Neurological Disease
Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with K_is of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D₂, D₃ and D₄ receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).

HY-15296S

Cabergoline-d5 FCE-21336-d5	Dopamine Receptor Autophagy	Endocrinology
Cabergoline-d5 (FCE-21336-d5) is the deuterium labeled Cabergoline. Cabergoline is an ergot derived-dopamine D₂-like receptor agonist that has high affinity for D₂, D₃, and 5-HT_2B receptors (K_i=0.7, 1.5, and 1.2, respectively).

HY-14782

Adoprazine SLV313	5-HT Receptor Dopamine Receptor	Neurological Disease
Adoprazine (SLV313) is a full 5-HT_1A receptor agonist with a pEC₅₀ of 9 at cloned h5-HT_1A receptors. Adoprazine (SLV313) is a full D₂ and D₃ receptor antagonist with pA₂s of 9.3 and 8.9 at hD₂ and hD₃ receptors, respectively. Adoprazine (SLV313) has the characteristics of atypical antipsychotics.

HY-14327

FAUC 213	Dopamine Receptor	Neurological Disease
FAUC 213 is an orally active and highly selective dopamine D₄ receptor complete antagonist with a K_i of 2.2 nM for hD_4.4. FAUC 213 has less activity on D₂ and D₃ receptors (K_is of 3.4 μM, 5.3 μM for hD₂, hD₃, respectively). FAUC 213 can cross the blood-brain barrier (BBB). FAUC 213 exhibits atypical antipsychotic characteristic.

HY-17355S

Pramipexole-d7 dihydrochloride	Dopamine Receptor	Neurological Disease
Pramipexole-d7 dihydrochloride is the deuterium labeled Pramipexole dihydrochloride. Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with K_is of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D₂, D₃ and D₄ receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).

HY-17355S1

Pramipexole-d5 dihydrochloride	Dopamine Receptor	Neurological Disease
Pramipexole-d5 (dihydrochloride) is deuterium labeled Pramipexole (dihydrochloride). Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).

HY-125751

UCSF924	Dopamine Receptor	Neurological Disease
UCSF924 is a potent and specific dopamine D4 receptor (DRD4) partial agonist with a EC₅₀ of 4.2 nM. UCSF924 has a high-affinity with a K_i value of 3 nM for DRD4 and shows no measurable affinity for D2, D3 or the F261V/L328F D4 mutant. UCSF924 is a 7.4-fold bias toward arrestin over Gαi/o signaling, referenced to quinpirole.

HY-15394S

(Rac)-Rotigotine-d7 hydrochloride	Dopamine Receptor Adrenergic Receptor 5-HT Receptor	Endocrinology Neurological Disease
(Rac)-Rotigotine-d7 (hydrochloride) is deuterium labeled (Rac)-Rotigotine (hydrochloride). (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-130344

SKF83959	Dopamine Receptor Sigma Receptor	Neurological Disease
SKF83959 is a potent and selective dopamine D₁-like receptor partial agonist. SKF83959 K_i values for rat D₁, D₅, D₂ and D₃ receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 belongs to benzazepine family and has improvements on cognitive dysfunction. SKF83959 can be used for the research of Alzheimer's disease and depression.

HY-116941

A-381393	Dopamine Receptor	Neurological Disease
A-381393 is a potent, selective, brain penetrate dopamine D₄ receptor antagonist, with K_is of 1.5, 1.9 and 1.6 nM for human dopamine D_4.4, D_4.2, and D_4.7 receptor, respectively, >2700-fold selectivity over D₁, D₂, D₃ and D₅ dopamine receptors. A-381393 shows moderate affinity for 5-HT_2A (K_i, 370 nM).

HY-103409

ABT-724 trihydrochloride	Dopamine Receptor	Neurological Disease
ABT-724 trihydrochloride is a potent and highly selective dopamine D₄ receptor agonist with an EC₅₀ of 12.4 nM for human dopamine D₄ receptor. ABT-724 trihydrochloride is a potent partial agonist at the rat D₄ (EC₅₀ of 14.3 nM) and the ferret D₄ receptor (EC₅₀ of 23.2 nM), and has no effect on dopamine D₁, D₂, D₃, or D₅ receptors. ABT-724 trihydrochloride could be useful for the treatment of erectile dysfunction and has favorable side-effect profile.

HY-100820

Sarizotan EMD 128130	5-HT Receptor Dopamine Receptor	Neurological Disease
Sarizotan (EMD 128130) is an orally active serotonin 5-HT_1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC₅₀ values of 6.5 nM (rat 5-HT_1A), 0.1 nM (human 5-HT_1A), 15.1 nM (rat D₂), 17 nM (human D₂), 6.8 nM (human D₃) and 2.4 nM (human D_4.2), respectively.

HY-131688

2-Chlorohexadecanoic acid	Others	Inflammation/Immunology
2-Chlorohexadecanoic acid, an inflammatory lipid mediator, interferes with protein palmitoylation,induces ER-stress markers, reduced the ER ATP content, and activates transcription and secretion of IL-6 as well as IL-8.2-Chlorohexadecanoic acid disrupts the mitochondrial membrane potential and induces procaspase-3 and PARP cleavage.2-Chlorohexadecanoic acid can across blood-brain barrier (BBB) and compromises ER- and mitochondrial functions in the human brain endothelial cell line hCMEC/D3.

HY-14330

ABT-724	Dopamine Receptor	Neurological Disease
ABT-724 is a potent and highly selective dopamine D₄ receptor agonist with an EC₅₀ of 12.4 nM for human dopamine D₄ receptor. ABT-724 is a potent partial agonist at the rat D₄ (EC₅₀ of 14.3 nM) and the ferret D₄ receptor (EC₅₀ of 23.2 nM). ABT-724 has no effect on dopamine D₁, D₂, D₃, or D₅ receptors. ABT-724 could be useful for the treatment of erectile dysfunction and has favorable side-effect profile.

HY-132742S

N-(4-Methoxy-3,5-dimethyl-2-pyridinyl)methyl Omeprazole-d3
HY-141719S

N-Acetyl-S-(3-carboxy-2-propyl)-L-cysteine-d3 disodium

HY-B1371A

Spiperone hydrochloride Spiroperidol hydrochloride	Dopamine Receptor 5-HT Receptor Adrenergic Receptor Chloride Channel	Inflammation/Immunology Neurological Disease
Spiperone hydrochloride (Spiroperidol hydrochloride) is a selective dopamine D₂ receptor (K_i values of 0.06 nM, 0.6 nM, 0.08 nM, ~350 nM, ~3500 nM for D₂, D₃, D₄, D₁ and D₅ receptors, respectively) and 5-HT_2A/5-HT_1A receptor (K_is of 1 nM/49 nM) antagonist. Spiperone hydrochloride is also a selective α1B-adrenoceptor antagonist. Spiperone hydrochloride activates calcium-activated chloride channel (CaCC). Antipsychotic and anti-inflammatory activities.

HY-103412

SKF 83959 hydrobromide	Dopamine Receptor Sigma Receptor	Neurological Disease
SKF83959 hydrobromide is a potent and selective dopamine D₁-like receptor partial agonist. SKF83959 hydrobromide K_i values for rat D₁, D₅, D₂ and D₃ receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 hydrobromide is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 hydrobromide belongs to benzazepine family and has improvements on cognitive dysfunction. SKF83959 hydrobromide can be used for the research of Alzheimer's disease and depression.

HY-12397

ZK159222	VD/VDR	Endocrinology
ZK159222, a 25-carboxylic ester analogue of 1α,25-(OH)2D3, is a potent 1α,25-(OH)2D3 receptor (VDR) antagonist. The mechanism of ZK159222 antagonistic action is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators. ZK159222 has a partial agonistic character.

HY-132748S

N-(4-Methoxy-3,5-dimethyl-2-pyridinyl)methyl Omeprazole-d3 Sulfone
HY-Z2769S

N-(4-Methoxy-3,5-dimethyl-2-pyridinyl)methyl Omeprazole-d3 Sulfide
HY-W020671S

N-[3-[3-(Dimethylamino)-1-oxo-2-propenyl]phenyl]-N-ethylacetamide-d3
Others Others

HY-109112

Brilaroxazine RP5063	Dopamine Receptor 5-HT Receptor	Inflammation/Immunology Neurological Disease
Brilaroxazine (RP5603) is a potent and orally active multimodal dopamine (DA)/serotonin (5-HT) modulator. Brilaroxazine is a partial agonist of dopamine (DA) D2, D3, and D4 receptors, 5-HT1A (K_i=1.5 nM) and 5-HT2A (K_i=2.5 nM), and has antagonist activity at 5-HT2B (K_i=0.19 nM), and 5-HT7 (K_i=2.7 nM) receptors. Brilaroxazine is an atypical antipsychotic agent, and has the potential to improve cognitive impairments in neuropsychiatric and neurological diseases in vivo.

HY-77517S

Ethyl 3-(4-(methylamino)-3-nitro-N-(pyridin-2-yl)benzamido)propanoate-d3 hydrochloride
HY-141786S

N-(4-(4-Fluorophenyl)-6-isopropyl-5-methylpyrimidin-2-yl)-N-methylmethanesulfonamide-d3
HY-132714S

4-O-Benzyl-N-[(benzyloxy)carbonyl]-3-O-methyl-L-DOPA-d3 Methyl Ester
HY-132642S

2,2,2-Trifluoroethyl 2,5-Bis(2,2,2-trifluoroethoxy)benzoate-d3
HY-W010950S

N-(Piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide-d3
HY-132833S

1,7-Dimethyl-1H-imidazo[4,5-g]quinoxalin-2-amine-d3
Others Metabolic Disease

HY-10003S

Alfacalcidol-d7 1-hydroxycholecalciferol-d7; 1.alpha.-Hydroxyvitamin D3-d7	VD/VDR	Metabolic Disease
Alfacalcidol-d7 (1-hydroxycholecalciferol-d7) is the deuterium labeled Alfacalcidol. Alfacalcidol (1-hydroxycholecalciferol) is a vitamin D active metabolites, acts as a non-selective VDR activator medication, and widely be used in the management of osteoporosis.

HY-136559

6-Azathymine	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Bacterial Influenza Virus	Infection
6-Azathymine, a 6-nitrogen analog of thymine, is a potent D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor. 6-Azathymine inhibits the biosynthesis of DNA, and has antibacterial and antiviral activities.

HY-115463

EB-3D	AMPK Apoptosis	Cancer
EB-3D is a potent and selective choline kinase α (ChoKα) inhibitor, with an IC₅₀ of 1 μM for ChoKα1. EB-3D exerts effects on ChoKα expression, AMPK activation, apoptosis, endoplasmic reticulum stress and lipid metabolism. EB-3D exhibits a potent antiproliferative activity in a panel of T-leukemia cell lines. Anti-cancer activity.

HY-12407

ZK168281	VD/VDR	Metabolic Disease
ZK168281 is a 25-carboxylic ester 1α,25(OH)₂D₃ analog and a pure VDR antagonist with a K_d value of 0.1 nM. ZK168281 is an effective inhibitor of the coactivator (CoA) interaction of its receptor.

HY-76326S

(S)-3-((1-methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)ethyl)-1H-indole-d3
HY-143988S

Nefazodone impurity 3-d6

Nefazodone impurity 3-d6 是 Nefazodone impurity 3氘代物。
HY-143968S

Ketotifen impurity 3-d4

Ketotifen impurity 3-d4 是 Ketotifen impurity 3氘代物。
HY-143977S

Loxapine impurity 3-d8 iodide

Loxapine impurity 3-d8 (iodide) 是 Loxapine impurity 3氘代物。
HY-132739S

3-Iodo-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide-d3
HY-Z2337S

2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfonyl)-1H-benzo[d]imidazole (Rabeprazole Impurity）-d3

HY-121037

Eggmanone EGM1	Phosphodiesterase (PDE)	Cancer
Eggmanone (EGM1) is a potent and selective phosphodiesterase 4 (PDE4) antagonist with an IC₅₀ of 72 nM for PDE4D3. Eggmanone shows approximately 40- to 50-fold selective for PDE4D3 over other PDEs. Eggmanone exerts its Hh-inhibitory effects through selective antagonism of PDE4, leading to protein kinase A activation and subsequent Hh blockade.

HY-143993S

Maytansinoid DM4 impurity 3-d6

Maytansinoid DM4 impurity 3-d6 是 Maytansinoid DM4 impurity 3氘代物。
HY-132672S

(4S)-3-[(2R)-2-[(2R)-2-(2,4-Difluorophenyl)oxiranyl]-1-oxopropyl]-4-benzyl-2-oxazolidinone-d3
HY-43347S

Benzyl 2-(4-(4-fluorobenzylcarbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-ylcarbamate-d3
HY-W005294S

Methyl 2-(2-(((benzyloxy)carbonyl)amino)propan-2-yl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylate-d3
HY-141726S

rel-(αR,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-methyl-1H-1,2,4-triazole-1-butanoic acid-d3
HY-141723S

(4R,5R)-5-(2,4-Difluorophenyl)-4-methyl-5-(1H-1,2,4-triazol-1-ylmethyl)-2-oxazolidinone-d3

HY-117571

Zatolmilast BPN14770	Phosphodiesterase (PDE)	Neurological Disease
Zatolmilast (BPN14770) is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC₅₀s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively.

HY-101776

Desmethyl-VS-5584 Desmethyl-SB2343	mTOR PI3K	Cancer
Desmethyl-VS-5584 is a dimethyl analog of VS-5584 which is an potent and selective *mTOR/PI3K* dual inhibitor with pyrido [2,3-d] pyrimidine structure.

HY-100246

CI-1044 PD-189659	Phosphodiesterase (PDE)	Inflammation/Immunology
CI-1044 is an orally active PDE4 inhibitor with IC₅₀s of 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and *PDE4D3*, respectively.

HY-132747S

(2S,3S)-[2-[3-(Acetoxy)-3,4-dihydro-2-(4-methoxyphenyl)-4-oxo-1,5-benzothiazepin-5(2H)-yl]ethyl]methyl-d3-carbamic Acid 1-Chloroethyl Ester
HY-132698S

2-Amino-4-chloro-N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]benzamide-d3

HY-15178

Oglemilast GRC 3886	Phosphodiesterase (PDE)	Inflammation/Immunology
Oglemilast (GRC 3886) is a potent and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC₅₀ of 0.5 nM for PDE4D3. Oglemilast inhibits pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo. Oglemilast has the potential for inflammatory airway diseases.

HY-143400

HSP70-IN-3	HSP	Cancer
HSP70-IN-3 is a potent HSP70 inhibitor (IC₅₀s of 1.1 and 1.9 μM in ASZ001 and C3H10T1/2, respectively). HSP70-IN-3 has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity and reduces expression of the oncogenic transcription factor GLI1.

Cat. No.	Product Name	Target	Research Area

HY-P2286

D-3
Phosphatase Cancer

D-3, a phosphorpeptide, is an efficient, simple, and specific iPSC-eliminating agent.