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Results for "

DDB1

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

6

Recombinant Proteins

1

Antibodies

1

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14658
    Thalidomide
    10+ Cited Publications

    		 Ligands for E3 Ligase Autophagy Inflammation/Immunology Cancer
    Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate.
    Thalidomide
  • HY-RS03606
    DDB1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others
    DDB1 Human Pre-designed siRNA Set A contains three designed siRNAs for DDB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    DDB1 Human Pre-designed siRNA Set A
    DDB1 Human Pre-designed siRNA Set A
  • HY-161166
    MM-02-57

    		Others Others
    MM-02-57 is a covalent DDB1 CUL4A adaptor protein recruiter [1].
    MM-02-57
  • HY-161167
    MM-02-08

    		PROTACs Cancer
    MM-02-08 is the potent BRD4 degrader and binds to DDB1 [1].
    MM-02-08
  • HY-150641
    CDK-IN-9

    		CDK Apoptosis DNA/RNA Synthesis Cancer
    CDK-IN-9 (compound 24) is a potent CDK inhibitor, also as a molecular glue inducing an interaction between CDK12 and DDB1, with an IC50 values of 4 nM for CDK2/E. CDK-IN-9 leads to polyubiquitination of cyclin K and its subsequent degradation. CDK-IN-9 induce apoptosis through dephosphorylation of retinoblastoma protein and RNA polymerase II [1].
    CDK-IN-9
  • HY-14658S
    Thalidomide-d4

    Thalidomide-d4 is a deuterium labeled Thalidomide. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2].
    Thalidomide-d4
  • HY-144981
    HQ461

    		CDK Molecular Glues Cancer
    HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation. HQ461-mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death [1].
    HQ461
  • HY-122653
    CCT367766

    		PROTACs Cancer
    CCT367766 is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 provides a potential chemical tool to study a largely unexplored protein [1].
    CCT367766
  • HY-122653A
    CCT367766 formic

    		PROTACs Cancer
    CCT367766 formic is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 formic exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 formic reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 formic provides a potential chemical tool to study a largely unexplored protein [1].
    CCT367766 formic

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