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Isoforms Recommended:	DDR2

Results for "

DDR2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bcr-Abl (1) c-Kit (3) c-Myc (1) Discoidin Domain Receptor (14) Ephrin Receptor (1) FGFR (1) FLT3 (2) JAK (1) PDGFR (1) Raf (1) RET (1) Small Interfering RNA (siRNA) (3) Trk Receptor (2) VEGFR (3)
By Research Areas:	Cancer (9) Inflammation/Immunology (7) Metabolic Disease (2)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112545

DDR2-IN-1 1 Publications Verification	Discoidin Domain Receptor	Metabolic Disease
DDR2-IN-1 is potent *DDR2* inhibitor with an IC₅₀ of 26 nM. DDR2-IN-1, compound 129, can be used for osteoarthritis research .

HY-114311

*FGFR1/DDR2* inhibitor 1**	FGFR Discoidin Domain Receptor	Cancer
FGFR1/DDR2 inhibitor 1 is an orally active inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoindin domain receptor 2 (DDR2), with IC₅₀ values of 31.1 nM and 3.2 nM, respectively. Antitumor activity .

HY-RS03623

DDR2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DDR2 Human Pre-designed siRNA Set A contains three designed siRNAs for DDR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DDR2 Human Pre-designed siRNA Set A DDR2 Human Pre-designed siRNA Set A

HY-RS03624

Ddr2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ddr2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ddr2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ddr2 Mouse Pre-designed siRNA Set A Ddr2 Mouse Pre-designed siRNA Set A

HY-RS03625

Ddr2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ddr2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ddr2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ddr2 Rat Pre-designed siRNA Set A Ddr2 Rat Pre-designed siRNA Set A

HY-W018931

DDR Inhibitor	Discoidin Domain Receptor	Cancer
DDR Inhibitor is a potent discoidin domain receptor (DDR) inhibitor, with an IC₅₀ of 3.3 nM for DDR2, and shows 53% inhibition on DDR1 at 1.5 nM.

HY-P1790

Axltide

JAK Metabolic Disease

Axltide is based on the mouse Insulin receptor substrate 1 (amino acid 979-989). Axltide is a substrate for Axl, DDR2, Mst1, and JAK2 kinases .

Axltide	JAK	Metabolic Disease
Axltide is based on the mouse Insulin receptor substrate 1 (amino acid 979-989). Axltide is a substrate for Axl, DDR2, Mst1, and JAK2 kinases .

HY-13979

DDR1-IN-1 3 Publications Verification	Discoidin Domain Receptor	Cancer
DDR1-IN-1 is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC₅₀ of 105 nM; 4-fold less potent for DDR2 (IC₅₀ = 413 nM) .

HY-13979A

DDR1-IN-1 dihydrochloride	Discoidin Domain Receptor	Cancer
DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC₅₀ of 105 nM; 4-fold less potent for DDR2 (IC₅₀ = 413 nM) .

HY-156552

DDR1/2 inhibitor-2	Discoidin Domain Receptor	Inflammation/Immunology Cancer
DDR1/2 inhibitor-2 (Example 31) is a *DDR1/DDR2* inhibitor, with IC₅₀ values less than 100 nM. DDR1/2 inhibitor-2 can be used for research of cancer and fibrotic diseases .

HY-14979A

ML786 dihydrochloride	Raf Bcr-Abl Discoidin Domain Receptor VEGFR RET Ephrin Receptor	Cancer
ML786 dihydrochloride is a potent and orally bioavailable Raf inhibitor, with IC₅₀s of 2.1, 4.2, and 2.5 nM for ^V600EΔB-Raf, wt B-Raf, and C-Raf, respectively. ML786 dihydrochloride also inhibits Abl-1, *DDR2, EPHA2, KDR, and RET* (IC₅₀=<0.5, 7.0, 11, 6.2, 0.8 nM). ML786 dihydrochloride can be used for the research of cancers .

HY-114173

DDR1-IN-4	Discoidin Domain Receptor	Inflammation/Immunology
DDR1-IN-4 (Compound 2.45) is a selective and potent Discoidin Domain Receptor 1 (DDR1) autophosphorylation inhibitor, with IC₅₀ values of 29 nM and 1.9 μM for DDR1 and DDR2, respectively .

HY-16961

Sitravatinib 1 Publications Verification MGCD516; MG-516	VEGFR c-Kit FLT3 Discoidin Domain Receptor Trk Receptor	Inflammation/Immunology Cancer
Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC₅₀s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively . Sitravatinib shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment ^[2].

HY-16961A

Sitravatinib malate MGCD516 malate; MG-516 malate	VEGFR c-Kit FLT3 Discoidin Domain Receptor Trk Receptor	Inflammation/Immunology Cancer
Sitravatinib malate (MGCD516 malate) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC₅₀s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively . Sitravatinib malate shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment ^[2].

HY-U00444

7rh 3 Publications Verification DDR1-IN-2	Discoidin Domain Receptor	Inflammation/Immunology
7rh (DDR1-IN-2) is a potent inhibitor of discoidin domain receptor 1 (DDR1), with an IC₅₀ of 13.1 nM, and also less potently inhibits DDR2, with an IC₅₀ of 203 nM. 7rh is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-160689

GW694590A UNC10112731	c-Myc c-Kit Discoidin Domain Receptor PDGFR	Others
GW694590A (UNC10112731) is a MYC protein stabilizer that increases endogenous MYC protein levels. GW694590A also targets receptor tyrosine kinases, inhibiting *DDR2, KIT* and PDGFRα by 81% at 1 μM. , 68% and 67%. GW694590A is a protein kinase inhibitor across ATP-dependent and -independent luciferases with potential effects on the Fluc reporter gene .

HY-114169

WRG-28	Discoidin Domain Receptor	Inflammation/Immunology Cancer
WRG-28 is a selective, extracellularly acting *DDR2* allosteric inhibitor, with an IC₅₀ of 230 nM. WRG-28 inhibits tumor invasion, migration and tumor-supporting effects of cancer-associated fibroblasts (CAFs). WRG-28 inhibits metastatic breast tumor cell colonization in the lungs. WRG-28 also shows good activity of relieving rheumatoid arthritis in CAIA model of mice ^[2].

HY-101034

CHMFL-ABL/KIT-155 CHMFL-ABL-KIT-155
CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155; compound 34) is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC₅₀s of 46 nM and 75 nM, respectively), and it also presents significant inhibitory activities to BLK (IC₅₀=81 nM), CSF1R (IC₅₀=227 nM), DDR1 (IC₅₀=116 nM), DDR2 (IC₅₀=325 nM), LCK (IC₅₀=12 nM) and PDGFRβ (IC₅₀=80 nM) kinases. CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155) arrests cell cycle progression and induces apoptosis .

HY-135401

VU6015929 1 Publications Verification	Discoidin Domain Receptor	Inflammation/Immunology
VU6015929 is a potent, selective and orally active dual discoidin domain receptor 1/2 (DDR1/2) inhibitor with IC₅₀s of 4.67 nM and 7.39 nM, respectively. VU6015929 potently blocks collagen-induced *DDR1* activation and collagen-IV production .

Cat. No.	Product Name	Target	Research Area

HY-P1790

Axltide

JAK Metabolic Disease

Axltide is based on the mouse Insulin receptor substrate 1 (amino acid 979-989). Axltide is a substrate for Axl, DDR2, Mst1, and JAK2 kinases .

Axltide	JAK	Metabolic Disease
Axltide is based on the mouse Insulin receptor substrate 1 (amino acid 979-989). Axltide is a substrate for Axl, DDR2, Mst1, and JAK2 kinases .

Recombinant Proteins Recommended:

DDR2

Species:	Human (4) Rhesus Macaque (2) Rat (2) Mouse (1)
Tag:	His (5) GST (2) Fc (3)
Source:	HEK293 (7) Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P75297

	DDR2 Protein, Rat (HEK293, His) Discoidin domain-containing receptor 2; CD167b; DDR2; Ntrkr3; Tkt; Tyro10	Rat	HEK293
	The DDR2 protein is a tyrosine kinase critical in tissue remodeling, acting as a cell surface receptor for fibrillar collagen and affecting cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is critical for bone development and centrally regulates osteoblast differentiation and chondrocyte maturation through MAP kinase signaling and activation of RUNX2. DDR2 Protein, Rat (HEK293, His) is the recombinant rat-derived DDR2 protein, expressed by HEK293 , with C-His labeled tag. The total length of DDR2 Protein, Rat (HEK293, His) is 399 a.a., with molecular weight of 50-70 kDa.

HY-P72673

	DDR2 Protein, Mouse (HEK293, His) Discoidin domain-containing receptor 2; CD167b; DDR2; Ntrkr3; Tkt; Tyro10	Mouse	HEK293
	The DDR2 protein is a tyrosine kinase and cell surface receptor for fibrillar collagen that critically regulates cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is crucial for bone development. It affects osteoblast differentiation and chondrocyte maturation through the MAP kinase signaling pathway and activates the transcription factor RUNX2. DDR2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DDR2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of DDR2 Protein, Mouse (HEK293, His) is 376 a.a., with molecular weight of 60-75 kDa.

HY-P76869

	DDR2 Protein, Human (HEK293, His) Discoidin domain-containing receptor 2; CD167b; DDR2; Ntrkr3; Tkt; Tyro10	Human	HEK293
	The DDR2 protein is a tyrosine kinase critical in tissue remodeling, acting as a cell surface receptor for fibrillar collagen and affecting cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is critical for bone development and centrally regulates osteoblast differentiation and chondrocyte maturation through MAP kinase signaling and activation of RUNX2. DDR2 Protein, Human (HEK293, His) is the recombinant human-derived DDR2 protein, expressed by HEK293 , with C-His labeled tag. The total length of DDR2 Protein, Human (HEK293, His) is 399 a.a., with molecular weight of ~54 kDa.

HY-P75298

	DDR2 Protein, Rat (HEK293, hFc) Discoidin domain-containing receptor 2; CD167b; DDR2; Ntrkr3; Tkt; Tyro10	Rat	HEK293
	The DDR2 protein is a tyrosine kinase critical in tissue remodeling, acting as a cell surface receptor for fibrillar collagen and affecting cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is critical for bone development and centrally regulates osteoblast differentiation and chondrocyte maturation through MAP kinase signaling and activation of RUNX2. DDR2 Protein, Rat (HEK293, hFc) is the recombinant rat-derived DDR2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of DDR2 Protein, Rat (HEK293, hFc) is 399 a.a., with molecular weight of ~110 kDa.

HY-P76868

	DDR2 Protein, Human (HEK293, Fc) Discoidin domain-containing receptor 2; CD167b; DDR2; Ntrkr3; Tkt; Tyro10	Human	HEK293
	The DDR2 protein is a tyrosine kinase critical in tissue remodeling, acting as a cell surface receptor for fibrillar collagen and affecting cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is critical for bone development and centrally regulates osteoblast differentiation and chondrocyte maturation through MAP kinase signaling and activation of RUNX2. DDR2 Protein, Human (HEK293, Fc) is the recombinant human-derived DDR2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of DDR2 Protein, Human (HEK293, Fc) is 399 a.a., with molecular weight of ~87 kDa.

HY-P75702

	DDR2 Protein, Rhesus Macaque (HEK293, Fc) Discoidin domain-containing receptor 2; CD167b; DDR2; Ntrkr3; Tkt; Tyro10	Rhesus Macaque	HEK293
	The DDR2 protein is a tyrosine kinase critical in tissue remodeling, acting as a cell surface receptor for fibrillar collagen and affecting cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is critical for bone development and centrally regulates osteoblast differentiation and chondrocyte maturation through MAP kinase signaling and activation of RUNX2. DDR2 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived DDR2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of DDR2 Protein, Rhesus Macaque (HEK293, Fc) is 399 a.a., with molecular weight of ~69.7 kDa.

HY-P75703

	DDR2 Protein, Rhesus Macaque (HEK293, His) Discoidin domain-containing receptor 2; CD167b; DDR2; Ntrkr3; Tkt; Tyro10	Rhesus Macaque	HEK293
	The DDR2 protein is a tyrosine kinase critical in tissue remodeling, acting as a cell surface receptor for fibrillar collagen and affecting cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is critical for bone development and centrally regulates osteoblast differentiation and chondrocyte maturation through MAP kinase signaling and activation of RUNX2. DDR2 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived DDR2 protein, expressed by HEK293 , with C-His labeled tag. The total length of DDR2 Protein, Rhesus Macaque (HEK293, His) is 399 a.a., with molecular weight of ~50-70 kDa.

HY-P76867

	DDR2 Protein, Human (sf9, His-GST) Discoidin domain-containing receptor 2; CD167b; DDR2; Ntrkr3; Tkt; Tyro10	Human	Sf9 insect cells
	The DDR2 protein is a tyrosine kinase critical in tissue remodeling, acting as a cell surface receptor for fibrillar collagen and affecting cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is critical for bone development and centrally regulates osteoblast differentiation and chondrocyte maturation through MAP kinase signaling and activation of RUNX2. DDR2 Protein, Human (sf9, His-GST) is the recombinant human-derived DDR2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of DDR2 Protein, Human (sf9, His-GST) is 434 a.a., with molecular weight of ~77 kDa.

HY-P702713

DDR2 Protein, Human (sf9, GST)

Discoidin domain-containing receptor 2; CD167b; DDR2; Ntrkr3; Tkt; Tyro10
Human Sf9 insect cells


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HY-P83622

DDR2 Antibody (YA3367) DDR2; NTRKR3; TKT; TYRO10; Discoidin domain-containing receptor 2; Discoidin domain receptor 2; CD167 antigen-like family member B; Discoidin domain-containing receptor tyrosine kinase 2; Neurotrophic tyrosine kinase; receptor-related 3; Re	WB	Human, Mouse, Rat

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