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Pathways Recommended: Cell Cycle/DNA Damage
Results for "

DNA

" in MedChemExpress (MCE) Product Catalog:

2770

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13

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109

Fluorescent Dye

76

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47

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83

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4

Inhibitory Antibodies

220

Natural
Products

46

Recombinant Proteins

156

Isotope-Labeled Compounds

59

Antibodies

102

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-149534

    DNA/RNA Synthesis Bacterial Infection
    DNA Gyrase-IN-9 (compound 4j) is an antibacterial agent that targets DNA gyrase. The MIC to inhibit Gram bacteria is 0.5-2 μg/mL, and the MBC to kill Gram bacteria is 2-8 μg/mL. DNA Gyrase-IN-9 inhibits DNA gyrase in Staphylococcus aureus with IC50=6.29 μg/mL .
    <em>DNA</em> Gyrase-IN-9
  • HY-161152

    DNA/RNA Synthesis Cancer
    DNA relaxation-IN-1 (compound 27) is a DNA Ligase 1 (DNA Lig1) inhibitor, which inhibits DNA ligation and disrupts Lig I’s DNA relaxation activity. DNA relaxation-IN-1 combined with Topotecan (HY-13768) exhibits a synergistic antiproliferative effect on colorectal cancer cells .
    <em>DNA</em> relaxation-IN-1
  • HY-147945

    DNA/RNA Synthesis Bacterial Infection
    DNA gyrase B-IN-1 (compound 13) is a potent DNA gyrase B inhibitor. DNA gyrase B-IN-1 shows inhibition of P. aeruginosa DNA gyrase B, with an IC50 of 2.2 μM. DNA gyrase B-IN-1 has good binding affinity and stability .
    <em>DNA</em> gyrase B-IN-1
  • HY-144333

    DNA Alkylator/Crosslinker Cancer
    DNA crosslinker 1 (dihydrochloride) is a potent DNA minor groove binder with DNA binding affinity (ΔTm) of 1.1 °C. DNA crosslinker 1 (dihydrochloride) can be used for researching anticancer .
    <em>DNA</em> crosslinker 1 dihydrochloride
  • HY-144336

    DNA Alkylator/Crosslinker Cancer
    DNA crosslinker 3 (dihydrochloride) (compound 1) is a potent DNA minor groove binder with DNA binding affinity (ΔTm) of 1.4 °C. DNA crosslinker 3 (dihydrochloride) can be used for researching anticancer .
    <em>DNA</em> crosslinker 3 dihydrochloride
  • HY-146566

    DNA-PK Cancer
    DNA-PK-IN-9 (compound YK6) is a potent DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of 10.47 nM. DNA-PK-IN-9 can be used for researching anticancer .
    <em>DNA</em>-PK-IN-9
  • HY-15586
    L67
    1 Publications Verification

    DNA Ligase Inhibitor

    DNA/RNA Synthesis Caspase Apoptosis Reactive Oxygen Species Cancer
    L67 (DNA Ligase Inhibitor) is a competitive DNA ligase inhibitor that effectively inhibits DNA ligases I/III (both IC50 are 10 μM). L67 (DNA Ligase Inhibitor) can cause nuclear DNA damage by reducing levels of mitochondrial DNA and increasing levels of mitochondrially-generated ROS. L67 (DNA Ligase Inhibitor) also activates the Caspase 1-dependent apoptosis pathway in cancer cells, can be used in cancer research .
    L67
  • HY-149379

    Bacterial DNA/RNA Synthesis Infection
    DNA gyrase B-IN-3 (Compound A) is a bacterial DNA gyrase B inhibitor (IC50: < 10 nM). DNA gyrase B-IN-3 has antibacterial activity against gram-positive strains .
    <em>DNA</em> gyrase B-IN-3
  • HY-144037

    DNA-PK Cancer
    DNA-PK-IN-4 is a potent inhibitor of DNA-PK. DNA-PK-IN-4 is a imidazolinone derivative compound. DNA-PK-IN-4 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-4 has the potential for the research of cancer disease (extracted from patent WO2021209055A1, compound 27) .
    <em>DNA</em>-PK-IN-4
  • HY-147818

    Bacterial DNA/RNA Synthesis Infection
    DNA Gyrase-IN-2 (Compound 22a) is a bacterial DNA gyrase B inhibitor with IC50s of 3.29-10.49 and 4.41-5.61 µM for E. coli DNA gyrase and M. tuberculosis DNA gyrase. Anti-tubercular and antibacterial activity .
    <em>DNA</em> Gyrase-IN-2
  • HY-147819

    Bacterial DNA/RNA Synthesis Infection
    DNA Gyrase-IN-3 (Compound 28) is a bacterial DNA gyrase B inhibitor with IC50s of 5.41-15.64 µM for E. coli DNA gyrase. Anti-tubercular and antibacterial activity .
    <em>DNA</em> Gyrase-IN-3
  • HY-144337

    DNA Alkylator/Crosslinker Cancer
    DNA crosslinker 4 (dihydrochloride) is a potent DNA minor groove binder. DNA crosslinker 4 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 4 (dihydrochloride) can be used for researching anticancer .
    <em>DNA</em> crosslinker 4 dihydrochloride
  • HY-146565

    DNA-PK Cancer
    DNA-PK-IN-8 is a highly potent, selective and orally active DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of 0.8 nM. DNA-PK-IN-8 exhibits synergistic antiproliferative activity against a series of cancer cell lines and significantly suppresses HL-60 tumor growth, when using in combination with Doxorubicin .
    <em>DNA</em>-PK-IN-8
  • HY-144335

    DNA Alkylator/Crosslinker Cancer
    DNA crosslinker 2 (dihydrochloride) is a potent DNA minor groove binder with DNA binding affinity (ΔTm) of 1.2 °C. DNA crosslinker 2 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 2 (dihydrochloride) can be used for researching anticancer .
    <em>DNA</em> crosslinker 2 dihydrochloride
  • HY-144039

    DNA-PK Cancer
    DNA-PK-IN-6 is a potent inhibitor of DNA-PK. DNA-PK-IN-6 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-6 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of agent resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021197159A1, compound 6) .
    <em>DNA</em>-PK-IN-6
  • HY-144038

    DNA-PK Cancer
    DNA-PK-IN-5 is a potent inhibitor of DNA-PK. DNA-PK-IN-5 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-5 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of agent resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021204111A1, compound 2) .
    <em>DNA</em>-PK-IN-5
  • HY-147948

    DNA/RNA Synthesis Bacterial Infection
    DNA Gyrase-IN-4 (compound 8p) is a potent DNA gyrase inhibitor, with an IC50 of 0.13 μM. DNA Gyrase-IN-4 shows excellent antibacterial activity against Staphylococcus aureus, Listeria monocytogenes, Salmonella and Escherichia coli, with MIC values of 0.05, 0.05, 0.05, and 8 μg/mL, respectively .
    <em>DNA</em> Gyrase-IN-4
  • HY-155007

    Bacterial Infection
    DNA gyrase B-IN-2 (Compound E) is a 2-aminobenzothiazole-based DNA gyrase B inhibitor with promising activity against ESKAPE bacterial pathogens. DNA gyrase B-IN-2 showed low nanomolar inhibition of DNA gyrase (IC50 < 10 nM) and broad-spectrum antibacterial activity against pathogens belonging to the ESKAPE group, with the minimum inhibitory concentration < 0.03 μg/mL for most Gram-positive strains and 4–16 μg/mL against Gram-negative E. coli, Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae.DNA gyrase B-IN-2 can be used for the research of infection .
    <em>DNA</em> gyrase B-IN-2
  • HY-109517

    DNA from calf thymus, Thymonucleic acid

    DNA/RNA Synthesis Inflammation/Immunology Cancer
    Calf thymus DNA (DNA from calf thymus) is high quality double-stranded template DNA isolated from the thymus of male and female calves. Calf thymus DNA can be used for the research of the interaction between DNA and agents .
    Calf thymus <em>DNA</em>
  • HY-153118

    ctDNA sodium, Type I, fibers; DNA sodium, from calf thymus, Type I, fibers; Thymonucleic acid sodium, Type I, fibers

    Biochemical Assay Reagents Others Cancer
    Deoxyribonucleic acid sodium, from calf thymus, Type I, fibers is the sodium salts form of Calf thymus DNA (HY-109517). Calf thymus DNA is a double-stranded template DNA isolated from calf thymus. It can be used to study the interaction between DNA and DNA binding agents, as well as the structure and function of DNA, for DNA quantification and used as a substrate for DNA polymerase analysis, etc​ .
    Deoxyribonucleic acid sodium, from calf thymus, Type I, fibers
  • HY-142943

    DNA-PK Cancer
    DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-dependent protein kinase (DNA-PK) is a DNA-PK enzyme complex composed of Ku70/Ku80 heterodimer and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA-PK-IN-1 has the potential for the research of cancer diseases (extracted from patent WO2021136463A1, compound 1) .
    <em>DNA</em>-PK-IN-1
  • HY-142944

    DNA-PK Cancer
    DNA-PK-IN-2 is a potent inhibitor of DNA-PK. DNA-dependent protein kinase (DNA-PK) is a DNA-PK enzyme complex composed of Ku70/Ku80 heterodimer and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA-PK-IN-2 has the potential for the research of cancer diseases (extracted from patent WO2021136462A1, compound 1) .
    <em>DNA</em>-PK-IN-2
  • HY-128917

    DNA/RNA Synthesis Infection
    DNA31 is a potent RNA polymerase inhibitor .
    <em>DNA</em>31
  • HY-149294

    DNA/RNA Synthesis Bacterial Infection
    DNA Gyrase-IN-8 is a potent DNA gyrase inhibitor with an IC50 value of 8.45 µM. DNA Gyrase-IN-8 shows antimicrobial activity .
    <em>DNA</em> Gyrase-IN-8
  • HY-153943

    DNA-PK Cancer
    DNA-PK-IN-10 is a DNA-PK inhibitor. DNA-PK-IN-10 can be used for the research of breast cancer and non-small cell lung cancer .
    <em>DNA</em>-PK-IN-10
  • HY-128729
    DNA2 inhibitor C5
    2 Publications Verification

    Others Cancer
    DNA2 inhibitor C5 is a potent, competitive and specific inhibitor of DNA2 nuclease activity with an IC50 of 20 μM. DNA2 inhibitor C5 inhibits nuclease, DNA dependent ATPase, helicase, and DNA binding activities of DNA2. DNA2 inhibitor C5 is a promising lead compound to develop sensitizers for cancer chemotherapeutics that cause replication stress .
    <em>DNA</em>2 inhibitor C5
  • HY-144036

    DNA-PK Cancer
    DNA-PK-IN-3 is a potent inhibitor of DNA-PK. DNA-PK-IN-3 synergistically enhances the effect of radiotherapy and chemotherapy and effectively inhibits tumor growth. DNA-PK-IN-3 also effectively reduces the damage to normal cells and reducing side effects. DNA-PK-IN-3 has the potential for the research of cancer disease (extracted from patent WO2021213460A1, compound 4) .
    <em>DNA</em>-PK-IN-3
  • HY-149851

    DNA/RNA Synthesis Bacterial Infection
    DNA Gyrase-IN-7 (compound 6d) is a novel Microbial DNA-Gyrase inhibitor .
    <em>DNA</em> Gyrase-IN-7
  • HY-147000

    Bacterial DNA/RNA Synthesis Infection
    DNA Gyrase-IN-1 (compound 42) is a potent and selective DNA gyrase inhibitor with an IC50 value of 2.6 µM. DNA Gyrase-IN-1 has high inhibitory activity against Mycobacterium tuberculosis (Mtb) with MIC of 0.49 µM. DNA Gyrase-IN-1 can be used for researching tuberculosis .
    <em>DNA</em> Gyrase-IN-1
  • HY-147988

    DNA/RNA Synthesis Bacterial Infection
    DNA Gyrase-IN-5 (Compound 8I-w) is a potent DNA gyrase inhibitor with an IC50 of 0.10 μM. DNA Gyrase-IN-5 shows antibacterial activities against wild type and drug-resistant strains .
    <em>DNA</em> Gyrase-IN-5
  • HY-160096

    DNA-PK Cancer
    DNA-PK-IN-11 is a DNA-PK inhibitor with an IC50 of <0.1 μM (DE102010035744A1; compound 36) .
    <em>DNA</em>-PK-IN-11
  • HY-163134

    DNA-PK Cancer
    DNA-PK-IN-12 (compound 31t) is an oral active DNA-PK inhibitor with the IC50 of 0.1 nM. DNA-PK-IN-12 inhibits cell growth and Hct116 cell colony formation with the IC50 of 33.28 μM, and shows antitumor activity in vivo .
    <em>DNA</em>-PK-IN-12
  • HY-155094

    DNA/RNA Synthesis Others
    DNA polymerase-IN-3 (Compd 5b) is a coumarin derivative that exhibits inhibitory activity against Taq DNA polymerase and can be used in proliferative disease research .
    <em>DNA</em> polymerase-IN-3
  • HY-W560689

    DNA/RNA Synthesis Cancer
    DNA polymerase-IN-1 (compound 2d) is a DNA polymerase inhibitor (IC50=20.7 μM) with antiproliferative activity against tumor cells .
    <em>DNA</em> polymerase-IN-1
  • HY-155092

    DNA/RNA Synthesis Others
    DNA polymerase-IN-2 (Compd 3c), a coumarin derivative, exhibits inhibitory activity against Taq DNA polymerase with IC50 of 48.25 μM , which can be used in value-added disease research .
    <em>DNA</em> polymerase-IN-2
  • HY-146227

    Topoisomerase Apoptosis Cancer
    DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .
    <em>DNA</em> topoisomerase II inhibitor 1
  • HY-155095

    Others Infection
    DNA polymerase-IN-4 (Compd 5c), a coumarin derivative, has antiretroviral activity with IC50 value of 134.22 μM .
    <em>DNA</em> polymerase-IN-4
  • HY-RS03838

    Small Interfering RNA (siRNA) Others
    DNA2 Human Pre-designed siRNA Set A contains three designed siRNAs for DNA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    DNA2 Human Pre-designed siRNA Set A
    DNA2 Human Pre-designed siRNA Set A
  • HY-149925

    Bacterial DNA/RNA Synthesis Topoisomerase Infection
    Antibacterial agent 138 is a benzothiazole inhibitor of bacterial DNA gyrase and topoisomerase IV. Antibacterial agent 138 exhibits favorable solubility and plasma protein binding. Antibacterial agent 138 has antibacterial activity against Gram-positive and Gram-negative strains. Antibacterial agent 138 is a dual GyrB and ParE inhibitor .
    <em>DNA</em> Gyrase-IN-6
  • HY-108882

    DNAse

    Others Inflammation/Immunology Cancer
    DNase I (EC 3.1.21.1) is an enzyme that degrade DNA, it plays a key role in the cleavage of extracellular DNA is crucial for limiting the inflammatory response and maintaining homeostasis. Exogenous deoxyribonuclease shows beneficial effects in inflammatory diseases and cancer .
    DNase I, Bovine pancreas
  • HY-P2863

    DNAse II

    Endonuclease Others
    Deoxyribonuclease II (DNase II) is an endonuclease that hydrolyzes the phosphodiester bonds of deoxyribonucleotides in native and denatured DNA, producing 3' phosphate and 5'-hydroxyl termini. Deoxyribonuclease II works best at acidic pH and is commonly used in biochemical research .
    Deoxyribonuclease II
  • HY-E70087

    DNA/RNA Synthesis Others
    Enhanced Taq DNA polymerase is a thermostable DNA polymerase that can be used in PCR .
    Enhanced Taq <em>DNA</em> polymerase
  • HY-147777

    Bacterial DNA/RNA Synthesis Infection
    14α-Demethylase/DNA Gyrase-IN-2 (Compound 6a) is a potent inhibitor of 14α-Demethylase/DNA Gyrase. 14α-Demethylase/DNA Gyrase-IN-2 has antimicrobial activities .
    14α-Demethylase/<em>DNA</em> Gyrase-IN-2
  • HY-147778

    Bacterial DNA/RNA Synthesis Infection
    14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) is a potent inhibitor of 14α-Demethylase/DNA Gyrase. 14α-Demethylase/DNA Gyrase-IN-1 has antimicrobial activities .
    14α-Demethylase/<em>DNA</em> Gyrase-IN-1
  • HY-E70216

    Others Others
    Bsu DNA polymerase, Large fragment is a polymerase derived from Bacillus subtilis. Bsu DNA polymerase, Large fragment is a DNA isothermal amplification polymerase with chain replacement activity, which used in RPA recombinase polymerase amplification technology .
    Bsu <em>DNA</em> polymerase, Large fragment
  • HY-147652

    DNA Stain Others
    G-quadruplex DNA fluorescence probe 1 (Compound E1) is a selective G-quadruplex DNA targeting fluorescent probe. G-quadruplex DNA fluorescence probe 1 can pass through membrane and enter living cells with low cytotoxicity .
    G-quadruplex <em>DNA</em> fluorescence probe 1
  • HY-E70084

    Others Others
    Tth DNA polymerase is a DNA polymerase from T. thermophilus that can be used for DNA sequencing and polymerase chain reaction (PCR) .
    Tth <em>DNA</em> polymerase
  • HY-E70086

    DNA/RNA Synthesis Others
    Taq DNA polymerase is a thermostable DNA polymerase that can be used in PCR .
    Taq <em>DNA</em> polymerase
  • HY-151380

    Others Infection
    LANA-DNA-IN-1 is a potent LANA-DNA inhibitor. LANA-DNA-IN-1 has inhibition activity for LBS2, LBS1 and LBS3 with IC50 values of 8 μM, 9μM and 8μM. LANA-DNA-IN-1shows against wild-type LANA with IC50 value of 53 μM. LANA-DNA-IN-1 can be used for the research of infection .
    LANA-<em>DNA</em>-IN-1
  • HY-155128

    Others Infection
    LANA-DNA-IN-2 (Compound 20) is a latency-associated nuclear antigen (LANA)-DNA interaction inhibitor. LANA-DNA-IN-2 can be used for research of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection .
    LANA-<em>DNA</em>-IN-2