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Isoforms Recommended:	DPP-8

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DPP8

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Dipeptidyl Peptidase (9) Ferroptosis (3) HIV (1) Isotope-Labeled Compounds (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (5) Infection (1) Inflammation/Immunology (5) Metabolic Disease (5)

10

Inhibitors & Agonists

2

Recombinant Proteins

1

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

1G244 3 Publications Verification	Dipeptidyl Peptidase Apoptosis	Cancer
1G244 is a potent *DPP8/9* inhibitor with IC₅₀s of 12 nM and 84 nM, respectively. 1G244 does not inhibit DPPIV and DPPII. 1G244 induces apoptosis in multiple myeloma cells and has anti-myeloma effects .

Anagliptin 3 Publications Verification SK-0403	Dipeptidyl Peptidase	Cardiovascular Disease Metabolic Disease
Anagliptin (SK-0403) is a highly selective, potent, orally active inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC₅₀ of 3.8 nM, and less selective at *DPP-8* and DDP-9 with IC₅₀s of 68 nM and 60 nM, respectively .

Alogliptin Benzoate 5 Publications Verification SYR 322	Dipeptidyl Peptidase Ferroptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Alogliptin Benzoate (SYR-322) is a potent, selective and orally active inhibitor of *DPP-4* with an IC₅₀ of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin Benzoate can be used for the research of type 2 diabetes .

DPP8 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DPP8 Human Pre-designed siRNA Set A contains three designed siRNAs for DPP8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DPP8 Human Pre-designed siRNA Set A DPP8 Human Pre-designed siRNA Set A

Anagliptin hydrochloride SK-0403 hydrochloride	Dipeptidyl Peptidase	Cardiovascular Disease Metabolic Disease
Anagliptin (SK-0403) hydrochloride is a highly selective, potent, orally active inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC₅₀ of 3.8 nM, and less selective at *DPP-8* and DDP-9 with IC₅₀s of 68 nM and 60 nM, respectively .

Alogliptin 5 Publications Verification SYR-322 free base	Dipeptidyl Peptidase Ferroptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Alogliptin (SYR-322 free base) is a potent, selective and orally active inhibitor of *DPP-4* with an IC₅₀ of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin can be used for the research of type 2 diabetes .

HY-A0023AS1

Alogliptin-d3 SYR-322-d₃ free base	Isotope-Labeled Compounds Dipeptidyl Peptidase Ferroptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Alogliptin-d₃ is the deuterium labeled Alogliptin. Alogliptin (SYR-322 free base) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin can be used for the research of type 2 diabetes[1][2][3].

ICeD-2	Dipeptidyl Peptidase HIV	Infection
ICeD-2 is a inducer of cell death, can induce HIV-1 infected cell kill. ICeD-2-mediated HIV-1 infected cell kill is dependent on HIV-1 protease activity. ICeD-2 potently blocks hydrolysis of Gly-Pro-AMC by dipeptidyl peptidase DPP8 and *DPP9. ICeD-2 shows strong stabilization of DPP*9 in PBMCs .

Talabostat mesylate Maximum Cited Publications 33 Publications Verification Val-boroPro mesylate; PT100 mesylate	Dipeptidyl Peptidase	Inflammation/Immunology Cancer
Talabostat mesylate (Val-boroPro mesylate; PT100 mesylate) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor (IC₅₀ < 4 nM; K_i = 0.18 nM) and the first clinical inhibitor of fibroblast activation protein (FAP) (IC₅₀ = 560 nM), inhibits DPP8/9 (IC₅₀ = 4/11 nM; K_i = 1.5/0.76 nM), quiescent cell proline dipeptidase (QPP) (IC₅₀ = 310 nM), DPP2, and some other DASH family enzymes. Antineoplastic and hematopoiesis- stimulating activities .

Talabostat Val-boroPro; PT100	Dipeptidyl Peptidase	Inflammation/Immunology Cancer
Talabostat (Val-boroPro; PT100) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor (IC₅₀ < 4 nM; K_i = 0.18 nM) and the first clinical inhibitor of fibroblast activation protein (FAP) (IC₅₀ = 560 nM), inhibits DPP8/9 (IC₅₀ = 4/11 nM; K_i = 1.5/0.76 nM), quiescent cell proline dipeptidase (QPP) (IC₅₀ = 310 nM), DPP2, and some other DASH family enzymes. Antineoplastic and hematopoiesis- stimulating activities .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

	DPP8 Protein, Human (Sf9) DPP8; Dipeptidyl peptidase 8; DP8; Dipeptidyl peptidase IV-related protein 1; DPRP-1; Dipeptidyl peptidase VIII; DPP VIII; Prolyl dipeptidase DPP8	Human	Sf9 insect cells
	The DPP8 protein cleaves N-terminal dipeptides from proteins with Pro or Ala at position 2. DPP8 Protein, Human (Sf9) is the recombinant human-derived DPP8 protein, expressed by Sf9 insect cells , with tag free. The total length of DPP8 Protein, Human (Sf9) is 898 a.a., .

	DPP8 Protein, Human (Sf9, His) DPP8; Dipeptidyl peptidase 8; DP8; Dipeptidyl peptidase IV-related protein 1; DPRP-1; Dipeptidyl peptidase VIII; DPP VIII; Prolyl dipeptidase DPP8	Human	Sf9 insect cells
	The DPP8 protein cleaves N-terminal dipeptides from proteins with Pro or Ala at position 2. DPP8 Protein, Human (Sf9, His) is the recombinant human-derived DPP8 protein, expressed by Sf9 insect cells , with N-8*His labeled tag. The total length of DPP8 Protein, Human (Sf9, His) is 898 a.a., .

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