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Results for "

Dasatinib

" in MedChemExpress (MCE) Product Catalog:

17

Inhibitors & Agonists

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10181
    Dasatinib
    Maximum Cited Publications
    85 Publications Verification

    BMS-354825

    		 Bcr-Abl Src Autophagy Apoptosis Cancer
    Dasatinib (BMS-354825) is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively . Dasatinib also induces apoptosis and autophagy.
    <em>Dasatinib</em>
  • HY-131669
    Dasatinib metabolite M6

    Dasatinib carboxylic acid

    		 Drug Metabolite Others
    Dasatinib metabolite M6 (Dasatinib carboxylic acid) is an oxidative metabolite of Dasatinib (HY-10181). Dasatinib is a potent and orally active dual Bcr-Abl and Src family tyrosine kinase inhibitor .
    <em>Dasatinib</em> metabolite M6
  • HY-133794
    Dasatinib N-oxide

    		Drug Metabolite Cancer
    Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor .
    <em>Dasatinib</em> N-oxide
  • HY-10181S
    Dasatinib-d8

    BMS-354825-d8
    Dasatinib-d8 is a deuterium labeled Dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.
    <em>Dasatinib</em>-d8
  • HY-133794S
    Dasatinib N-oxide-d8

    		Drug Metabolite Cancer
    Dasatinib N-oxide-d8 is the deuterium labeled Dasatinib N-oxide. Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor[1][2].
    <em>Dasatinib</em> N-oxide-d8
  • HY-156883
    Dasatinib analog-1

    		Cytochrome P450 Others
    Dasatinib analog-1 (compound 5826) inhibits CYP3A4 viability with a Ki value of 5.4 μM. Dasatinib analog-1 blocks the formation of glutathione adducts .
    <em>Dasatinib</em> analog-1
  • HY-10181A
    Dasatinib hydrochloride
    Maximum Cited Publications
    85 Publications Verification

    BMS-354825 hydrochloride

    		 Bcr-Abl Src Autophagy Apoptosis Cancer
    Dasatinib (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib hydrochloride inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively . Dasatinib hydrochloride also induces apoptosis and autophagy.
    <em>Dasatinib</em> hydrochloride
  • HY-10181B
    Dasatinib monohydrate
    Maximum Cited Publications
    85 Publications Verification

    BMS-354825 monohydrate
    Dasatinib (BMS-354825) monohydrate is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib monohydrate inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively . Dasatinib monohydrate also induces apoptosis and autophagy.
    <em>Dasatinib</em> monohydrate
  • HY-111857
    Dasatinib carbaldehyde

    BMS-354825 carbaldehyde; PROTAC ABL binding moiety 4

    		 Ligands for Target Protein for PROTAC Cancer
    Dasatinib carbaldehyde (BMS-354825 carbaldehyde), the Dasatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .
    <em>Dasatinib</em> carbaldehyde
  • HY-W700620
    Hydroxymethyl dasatinib

    		Bcr-Abl Drug Metabolite Apoptosis Src Inflammation/Immunology
    Hydroxymethyl dasatinib (M24), a benzylhydroxy metabolite of Dasatinib (HY-10181), exhibits an IC50 of 46.7nM in K562 CML cells .
    Hydroxymethyl <em>dasatinib</em>
  • HY-107447S
    N-Deshydroxyethyl Dasatinib-d8

    		Isotope-Labeled Compounds Ligands for Target Protein for PROTAC Cancer
    N-Deshydroxyethyl Dasatinib-d8 is the deuterium labeled N-Deshydroxyethyl Dasatinib. N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825), the Dasatinib-based moiety, binds to IAP ligand via a linker to form SNIPER to degrade ABL[1].
    N-Deshydroxyethyl <em>Dasatinib</em>-d8
  • HY-107447
    N-Deshydroxyethyl Dasatinib

    N-Deshydroxyethyl BMS-354825

    		 Drug Metabolite Inflammation/Immunology Cancer
    N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, Dasatinib is a multi-kinase inhibitor that potently inhibits Bcr-Abl, Src family and platelet-derived growth factor receptor kinases. N-Deshydroxyethyl Dasatinib can be used in cancer and immune disease research .
    N-Deshydroxyethyl <em>Dasatinib</em>
  • HY-157497
    DA5-HTL

    		Bcr-Abl Src Autophagy Apoptosis Cancer
    DA5-HTL is a compound combined dasatinib with HaloTag system efficiently inhibits the growth of the cancer cells with GI50 of 1.923 nM .
    DA5-HTL
  • HY-111872
    SNIPER(ABL)-020

    		SNIPERs Bcr-Abl Cancer
    SNIPER(ABL)-020, conjugating Dasatinib (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein .
    SNIPER(ABL)-020
  • HY-111873
    SNIPER(ABL)-019

    		SNIPERs Bcr-Abl Cancer
    SNIPER(ABL)-019, conjugating Dasatinib (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 0.3 μM .
    SNIPER(ABL)-019
  • HY-111874
    SNIPER(ABL)-039

    		SNIPERs Bcr-Abl Cancer
    SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively .
    SNIPER(ABL)-039
  • HY-156092
    Antitumor photosensitizer-4

    		BCRP Apoptosis Cancer
    Antitumor photosensitizer-4 (compound 10b) is a potent tyrosine kinase inhibitor (TKI) targeting ABCG2. Antitumor photosensitizer-4 is a photosensitizer (PS) consisting of a conjugate of dasatinib (HY-10181) and imatinib (HY-15463). Antitumor photosensitizer-4 induces apoptosis and ROS production and exhibits strong phototoxicity to HepG2 and B16-F10 cells .
    Antitumor photosensitizer-4

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