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Results for "

Depression

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (27) ADC Cytotoxin (1) Adrenergic Receptor (5) Amino Acid Derivatives (2) Amyloid-β (1) Antibiotic (2) Apoptosis (5) Autophagy (8) Bacterial (2) Calcium Channel (3) Cannabinoid Receptor (1) Cholinesterase (ChE) (6) Complement System (1) CRFR (3) Cytochrome P450 (4) Dopamine Receptor (11) Dopamine Transporter (1) Drug Metabolite (10) Endogenous Metabolite (5) FAAH (1) GABA Receptor (5) GCGR (1) Glucocorticoid Receptor (1) Glyoxalase (GLO) (2) GlyT (1) GSK-3 (1) Histamine Receptor (3) Histone Demethylase (2) iGluR (11) Indoleamine 2,3-Dioxygenase (IDO) (1) Isotope-Labeled Compounds (5) Lipoxygenase (1) LPL Receptor (3) mAChR (3) MCHR1 (GPR24) (1) mGluR (2) Mitophagy (1) Monoamine Oxidase (24) Monoamine Transporter (2) mTOR (2) nAChR (3) Neurokinin Receptor (2) Neuropeptide Y Receptor (1) Opioid Receptor (3) Orexin Receptor (OX Receptor) (1) Oxytocin Receptor (1) P2X Receptor (2) Penicillin-binding protein (PBP) (1) Phosphatase (1) Phosphodiesterase (PDE) (2) Potassium Channel (3) Reactive Oxygen Species (3) ROS Kinase (1) SARS-CoV (2) Serotonin Transporter (18) Sigma Receptor (2) Sodium Channel (3) Trk Receptor (1) TRP Channel (2) Vasopressin Receptor (1)
By Research Areas:	Cancer (22) Cardiovascular Disease (3) Endocrinology (10) Infection (3) Inflammation/Immunology (18) Metabolic Disease (8) Neurological Disease (168)
Click Chemistry:	Alkynes (3)

185

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-U00050S

(E)-10-Hydroxynortriptyline-d3 E-10-OH-NT-d₃	Isotope-Labeled Compounds Drug Metabolite	Neurological Disease
(E)-10-Hydroxynortriptyline-d₃ is a deuterium labeled (E)-10-Hydroxy Nortriptyline. (E)-10-Hydroxy Nortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1].

HY-W224327A

Pheniprazine hydrochloride β-Phenylisopropylhydrazine hydrochloride	Monoamine Oxidase	Neurological Disease
Pheniprazine hydrochloride is a potent and long acting inhibitor of monoamine oxidase. Pheniprazine has the potential for the research of depression .

HY-160668

Histamine H3 antagonist-1	Histamine Receptor Serotonin Transporter	Neurological Disease
Histamine H3 antagonist-1 (Compound 10o) is a histamine H3 antagonist and a serotonin reuptake inhibitor, which can be used in depression research .

HY-W224327

Pheniprazine β-Phenylisopropylhydrazine	Monoamine Oxidase	Neurological Disease
Pheniprazine is a potent and long acting inhibitor of monoamine oxidase. Pheniprazine has the potential for the research of depression .

HY-157392

hMAO-A-IN-1	Monoamine Oxidase	Neurological Disease
hMAO-A-IN-1 (compound 8) is a potent hMAO-A inhibitor, with an IC₅₀ of 90 nM. hMAO-A-IN-1 can be used for the research of anxiety and depression .

HY-148145

Mebanazine

Monoamine Oxidase Neurological Disease

Mebanazine is a potent monoamine oxidase (MAO) inhibitor. Mebanazine can be used in research of depression .

Mebanazine	Monoamine Oxidase	Neurological Disease
Mebanazine is a potent monoamine oxidase (MAO) inhibitor. Mebanazine can be used in research of depression .

HY-10935

LY450108 1 Publications Verification	iGluR	Neurological Disease
LY450108 is a potent AMPA receptor potentiator. LY450108 has the potential for depression and Parkinson's disease research .

HY-123478

Fengabine

SL 79229
GABA Receptor Neurological Disease

Fengabine is a GABAergic antidepressant agent. Fengabine can be used for the research of depression .

Fengabine SL 79229	GABA Receptor	Neurological Disease
Fengabine is a GABAergic antidepressant agent. Fengabine can be used for the research of depression .

HY-100646A

(Z)-10-Hydroxynortriptyline	Drug Metabolite	Neurological Disease
(Z)-10-Hydroxynortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression .

HY-148158

Pivalylbenzhydrazine Pivhydrazine	Monoamine Oxidase	Neurological Disease Inflammation/Immunology
Pivalylbenzhydrazine (Pivhydrazine) is a potent monoamine oxidase (MAO) inhibitor. Pivalylbenzhydrazine decreases cartilage growth in normal rats. Pivalylbenzhydrazine can be used in research of depression .

HY-148146

Phenoxypropazine

Monoamine Oxidase Neurological Disease

Phenoxypropazine is a potent monoamine oxidase (MAO) inhibitor. Phenoxypropazine can be used in research of depression .

Phenoxypropazine	Monoamine Oxidase	Neurological Disease
Phenoxypropazine is a potent monoamine oxidase (MAO) inhibitor. Phenoxypropazine can be used in research of depression .

HY-B1115

Buspirone hydrochloride 1 Publications Verification	5-HT Receptor Reactive Oxygen Species	Neurological Disease Cancer
Buspirone hydrochloride is a 5-HT1A receptor agonist. Buspirone hydrochloride can be used for anxiety and depression research .

HY-146654

Glyoxalase I inhibitor 2	Glyoxalase (GLO)	Cancer
Glyoxalase I inhibitor 2 (compound 26) is a potent glyoxalase I (GLO1) inhibitor with an IC₅₀ of 0.5 µM. Glyoxalase I inhibitor 2 has the potential for the research of depression and anxiety .

HY-100046

Nordoxepin hydrochloride Desmethyldoxepin hydrochloride	Drug Metabolite	Neurological Disease
Nordoxepin hydrochloride is the major metabolite of Doxepin. Doxepin is a tricyclic antidepressant that is widely prescribed for the research of mild depression .

HY-146655

Glyoxalase I inhibitor 3	Glyoxalase (GLO)	Cancer
Glyoxalase I inhibitor 3 (compound 22g) is a potent glyoxalase I (GLO1) inhibitor with an IC₅₀ of 0.011 µM. Glyoxalase I inhibitor 3 has the potential for the research of depression and anxiety .

HY-131289

LY3020371	mGluR	Neurological Disease
LY3020371 is a potent and selective antagonist of glutamate (mGlu) 2/3 receptor, with K_is of 5.26 and 2.50 nM for hmGluR2 and hmGluR3, respectively. LY3020371 can be used for the research of depression .

HY-14560C

Reboxetine mesylate 2 Publications Verification FCE20124 mesylate; PNU155950E mesylate	Adrenergic Receptor	Neurological Disease
Reboxetine mesylate (FCE20124 mesylate) is a potent, selective, and specific noradrenaline reuptake inhibitor (NARI) for the research of depression. Reboxetine mesylate inhibits the uptake of norepinephrine, with a K_i of 8 nM .

HY-112528

Glycerophospho-N-palmitoyl ethanolamine GP-NPEA	Others	Metabolic Disease
Glycerophospho-N-palmitoyl ethanolamine (GP-NPEA) is a metabolic precursor of palmitoyl ethanolamide PEA (HY-157829). Glycerophospho-N-palmitoyl ethanolamine decreases in the cortex of CUMS rats, which may be related to a disorder in the endocannabinoid system arising after the onset of depression .

HY-14225

BMS-764459	CRFR Cytochrome P450	Neurological Disease
BMS-764459 is a CRF1 antagonist. BMS-764459 can be used for the research of neurological disorders such as depression and anxiety. BMS-764459 is also an atypical CYP1A1 inducer .

HY-148159

Safrazine	Monoamine Oxidase	Neurological Disease
Safrazine is an irreversible, non-specific and orally active monoamine oxidase (MAO) inhibitor. Safrazine can be used for the research of depression .

HY-P2259

TAT-GluA2 3Y	iGluR	Neurological Disease
TAT-GluA2 3Y, an interference peptide, blocks long-term depression (LTD) at glutamatergic synapses by disrupting the endocytosis of AMPAR. TAT-GluA2 3Y can alleviate Pentobarbital-induced spatial memory deficits and synaptic depression .

HY-120686

S-14671	5-HT Receptor	Neurological Disease
S-14671 is a high-affinity 5-HT_1A agonist (pK_i=9.3). S-14671 can be used for research on neurological diseases, such as anti-anxiety, anti-depression, etc .

HY-108920

4-Chlorokynurenine 4-Cl-KYN; AV-101	Others	Neurological Disease
4-Chlorokynurenine is a prodrug of a NMDA receptor antagonist. 4-Chlorokynurenine has orally active and blood-brain permeability that can be used for the research of depression .

HY-157934

MAO-IN-4	Monoamine Oxidase	Neurological Disease
MAO-IN-4 (Compound 2l) is a monoamine oxidase (MAO) inhibitor, with IC₅₀ values of 0.07 and 0.75 μM for MAO-A and MAO-B Enzymes, respectively. MAO-IN-4 can be used for the research of depression and Parkinson’s disease (PD) .

HY-118461

PD 120697	Dopamine Receptor	Neurological Disease
PD 120697 is an orally active dopamine (DA) agonist. PD 120697 inhibits striatal DA synthesis, DA neuronal firing, spontaneous locomotor activity, and reverses Reserpine (HY-N0480)-induced depression .

HY-116916

Acetophenazine	Dopamine Receptor	Neurological Disease
Acetophenazine, a phenothiazine derivative, is an antipsychotic agent. Acetophenazine primarily blocks dopamine D2 receptors in the brain. Acetophenazine can be used for researching psychotic disorders such as schizophrenia and anxious depression .

HY-100454

CGP 25454A	Dopamine Receptor	Neurological Disease
CGP 25454A is a selective presynaptic dopamine autoreceptor antagonist which induces the increase of dopamine and acetyl choline. CGP 25454A can be used for major depression research .

HY-151108

IDO1/TDO-IN-4	Indoleamine 2,3-Dioxygenase (IDO)	Neurological Disease Inflammation/Immunology
IDO1/TDO-IN-4 is a potent IDO1/TDO dual inhibitor, with IC₅₀ values of 3.53 μM (IDO1) and 1.15 μM (TDO). IDO1/TDO-IN-4 forms hydrogen bond with IDO1, and π−π stacking interaction with TDO. IDO1/TDO-IN-4 can be used in the research of depression, and depression-induced infectious, metabolic, and autoimmune disorders .

HY-B1262

Acetophenazine dimaleate 1 Publications Verification	Dopamine Receptor	Neurological Disease
Acetophenazine dimaleate, a phenothiazine derivative, is an antipsychotic agent. Acetophenazine dimaleate primarily blocks dopamine D2 receptors in the brain. Acetophenazine dimaleate can be used for researching psychotic disorders such as schizophrenia and anxious depression .

HY-113323

3-Methoxy-4-hydroxyphenylglycol HMPG; MHPG; MOPEG	Endogenous Metabolite	Neurological Disease
3-Methoxy-4-hydroxyphenylglycol (HMPG) is a metabolite of norepinephrine degradation in the brain. 3-Methoxy-4-hydroxyphenylglycol is an indicators of central nervous system noradrenergic activity. 3-Methoxy-4-hydroxyphenylglycol can be used for research of depression, chronic schizophrenia, etc .

HY-120229

GGTI-2147	ROS Kinase	Neurological Disease
GGTI-2147 is a potent GGTase I inhibitor. GGTI-2147 blocks geranyl-geranylation of Rap1A and reduces the activity of Rac1 (one of substrates for GGTI) and ameliorates the OGD/R-induced neuronal apoptosis.GGTI-2147 can be used for neurodevelopmental disorders research, such as autism, depression, and schizophrenia .

HY-19668A

SGS518 oxalate	5-HT Receptor	Neurological Disease
SGS518 oxalate is a selective 5-HT₆R antagonist. SGS518 oxalate can be used for the research of cognitive impairments such as amnesia, anxiety and depression, and it is effective in protecting mouse retina at high doses ^[1]

HY-N0505

Rosiridin	Monoamine Oxidase	Neurological Disease
Rosiridin inhibits MAO A and MAO B with potential beneficial effect in depression and senile dementia. Rosiridin shows an inhibition of 83.8% against MAO B at 10 μM (pIC₅₀=5.38) .

HY-107614

1-Oleoyl lysophosphatidic acid sodium 1-Oleoyl-sn-glycero-3-phosphate sodium; 1-Oleoyl-LPA sodium	LPL Receptor	Neurological Disease
1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) sodium, a potent bioactive phospholipid, is a LPA receptor activator. 1-Oleoyl lysophosphatidic acid sodium can promote mitosis by inducing DNA synthesis. 1-Oleoyl lysophosphatidic acid sodium is also involved in normal and pathological emotional responses, including anxiety and depression .

HY-W380450

Viloxazine Viloxazin; Emovit	5-HT Receptor Adrenergic Receptor	Neurological Disease
Viloxazine (Viloxazin) is a norepinephrine reuptake inhibitor, also a potent 5-HT_2C agonist and 5-HT_2B antagonist with an EC₅₀ of 32 μM and an IC₅₀ of 27 μM for 5-HT_2C and 5-HT_2B, respectively. The mechanism of action of Viloxazine predominantly involves serotonergic and noradrenergic pathways. Viloxazine can be used for researching depression .

HY-N6057

Obtusin	Monoamine Oxidase	Neurological Disease
Obtusin, isolated from Cassia obtusifolia Linn seed, is a highly selective and competitive human monoamine oxidase-A (hMAO-A) inhibitor with an IC₅₀ of 11.12 μM and a K_i of 6.15 μM. Obtusin plays a preventive role in neurodegenerative diseases, especially anxiety and depression .

HY-P3581

PE 22-28	Potassium Channel	Neurological Disease
PE 22-28 is a TREK-1 inhibitor with IC₅₀ value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression .

HY-143438

2-PAT	Monoamine Oxidase	Neurological Disease
2-PAT, an analogue of Rasagiline and Selegiline, a reversible MAO-A inhibitor with an IC₅₀ of 0.721 µM. 2-PAT is an inactivator of MAO-B with an IC₅₀ of 14.6 µM. 2-PAT has the potential for Parkinson’s disease and depression research .

HY-110175

CX614	iGluR	Neurological Disease
CX614 is a positive variant modulator of AMPA receptors that enhances excitatory postsynaptic potentials (amplitude and duration) by blocking and slowing the inactivation of responses to glutamate and automatically evokes excitatory postsynaptic currents in neuronal cultures. CX614 can be used in the study of psychiatric disorders such as depression .

HY-14258

Escitalopram 3 Publications Verification (S)-Citalopram; (S)-(+)-Citalopram	Serotonin Transporter	Neurological Disease
Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression .

HY-B0457

Clomipramine hydrochloride 1 Publications Verification Chlorimipramine hydrochloride; G-34586 hydrochloride; NSC-169865 hydrochloride	Serotonin Transporter	Neurological Disease
Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC₅₀ value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD) .

HY-B0457A

Clomipramine 1 Publications Verification Chlorimipramine; G-34586; NSC-169865	Serotonin Transporter	Neurological Disease
Clomipramine (Chlorimipramine) is a potent 5-HT reuptake blocker with the IC₅₀ value of 1.5 nM. Clomipramine is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD) .

HY-14258A

Escitalopram oxalate 3 Publications Verification (S)-Citalopram oxalate; (S)-(+)-Citalopram oxalate	Serotonin Transporter	Neurological Disease
Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .

HY-17612

Evenamide NW-3509	Sodium Channel	Neurological Disease
Evenamide (NW-3509) is an orally available voltage-gated sodium channel (VGSC) blocker (K_i=0.4 µM) for the research of schizophrenia. Evenamide shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness .

HY-103089

LY393558	5-HT Receptor	Neurological Disease
LY393558 is a potent and orally active inhibitor of the 5-HT transporter and an antagonist of 5-HT1B and 5-HT1D receptors. LY393558 increase the extracellular levels of 5-HT in mice model frontal cortex. LY393558 can be used for researching depression .

HY-116807

Dihydrolipoic Acid DHLA	Reactive Oxygen Species	Neurological Disease Inflammation/Immunology
Dihydrolipoic Acid (DHLA) is an excellent antioxidant capable of scavenging almost any oxygen-centered radical . Dihydrolipoic acid exhibits anti-inflammatory properties in various diseases. Dihydrolipoic Acid exerts a preventive effect via ERK/Nrf2/HO-1/ROS/NLRP3 pathway in LPS-induced sickness behavior rats. Dihydrolipoic Acid can be used for the reaserch of depression .

HY-10400

Ladostigil hemitartrate TV-3326 hemitartrate	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
Ladostigil (TV-3326) hemitartrate is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC₅₀s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil hemitartrate exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil hemitartrate can be used for the research of depression and Alzheimer's disease . Ladostigil (hemitartrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-118064

(R)-Thionisoxetine LY-368975	Others	Neurological Disease
(R)-Thionisoxetine is a potent and selective inhibitor of central and peripheral norepinephrine (NE) uptake. (R)-thionisoxetine prevented hypothalamic NE depletion by 6-hydroxydopamine with an ED₅₀ of 0.21 mg/kg. (R)-Thionisoxetine can be used for the research of a variety of diseases including depression and urinary incontinence .

HY-W094474

Lithium chloride hydrate 1 Publications Verification hydrate/monohydrateortrihydrate	GSK-3 Apoptosis	Infection Neurological Disease
Lithium chloride hydrate, an orally active mood stabilizer, is a potent virus inhibitor and effective immunomodulatory agent. Lithium chloride hydrate has antidepressant activity by inhibiting GSK3β and promoting neurogenesis. Lithium chloride hydrate alleviates cognition dysfunction and the symptoms of acute mania and depression. Lithium chloride hydrate can also be used for research of virus infection and Alzheimer's disease .

HY-14563

VU10010	mAChR	Neurological Disease
VU10010 is a potent, highly selective and allosteric M₄ mAChR potentiator with an EC₅₀ of 400 nM. VU10010 binds to an allosteric site on M₄ mAChR and increases affinity for acetylcholine and coupling to G proteins. VU10010 increases carbachol-induced depression of transmission at excitatory but not inhibitory synapses in the hippocampus .

Cat. No.	Product Name

HY-L108

Antidepressant Compound Library

1687 compounds

Depression is a serious global affective disorder and one of the most common neurological diseases whose clinical manifestations are low mood, loss of interest, anhedonia, loss of energy, and fatigue, people with major depressive disorder (MDD) can even have suicidal thoughts and behaviors.

Currently available antidepressants have significant limitations, including a long time lag for a therapeutic response (weeks to months) and low response rates. This is particularly problematic for a disease with a high suicide rate. Therefore, the development of new antidepressant drugs is particularly urgent.

MCE offers a unique collection of 1687 compounds with antidepressant activities or targeting the unique targets of depression. MCE Antidepressant Compound Library is a useful tool for exploring the mechanism of depression and discovering new drugs for depression.

HY-L078

Gut Microbial Metabolite Library

500 compounds

Accumulating evidence has revealed that intestinal microbiota play an important role in human health and disease, including cardiovascular diseases, inflammatory bowel disease, diabetes, obesity, cancer, and depression, etc. Changes in the composition of gut microbiota associated with disease, referred to as dysbiosis, have been linked to pathologies. Indeed, the gut microbiome functions like an endocrine organ, generating bioactive metabolites which play important roles in human metabolism, health, and disease. Gut microbiome has become a novel therapeutic target for many diseases. Analysis and identification of gut microbial metabolite will contribute to the development of therapeutic methods.

In order to meet the need of gut microbiome research, MCE carefully selected a unique collection of 500 gut microbial metabolites. MCE gut microbial metabolite library is a powerful tool for gut microbiome research and gut microbiome -related drug discovery.

Cat. No.	Product Name	Target	Research Area

HY-P2259

TAT-GluA2 3Y	iGluR	Neurological Disease
TAT-GluA2 3Y, an interference peptide, blocks long-term depression (LTD) at glutamatergic synapses by disrupting the endocytosis of AMPAR. TAT-GluA2 3Y can alleviate Pentobarbital-induced spatial memory deficits and synaptic depression .

HY-P3646

[DAla2] Dynorphin A (1-9) (porcine)	Peptides	Neurological Disease
[DAla2] Dynorphin A (1-9) (porcine) is a dynorphin, which can be used in studies of analgesic, addiction, and depression.

HY-P3581

PE 22-28	Potassium Channel	Neurological Disease
PE 22-28 is a TREK-1 inhibitor with IC₅₀ value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression .

HY-P7060

NT 13 TPPT	iGluR	Neurological Disease
NT 13 (TPPT) is a tetrapeptide having the amino acid sequence L-threonyl-L-prolyl-L-prolyl-L-threonine amide. NT 13 is a partial N-methyl-D-aspartate receptor (NMDAR) agonist used in the study of depression, anxiety, and other related diseases.

HY-P10029

Sakura-6	Peptides	Neurological Disease
Sakura-6 is a SERT-nnos interaction promoter that significantly increases the SERT-nnos complex, but reduces the level of SERT on the cell surface. Acute injection of Sakura-6 into the dorsal raphe nucleus (DRN) causes depression-like behavior in mice .

HY-P3467

(Thr4,Gly7)-Oxytocin	Oxytocin Receptor Potassium Channel	Neurological Disease
(Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K ⁺ channels. .

HY-P4106

Tat-GluR23Y, scrambled	Amino Acid Derivatives	Neurological Disease
Tat-GluR23Y, scrambled is the scrambled peptide of Tat-GluR23Y (HY-P2259). Tat-GluR23Y is a synthetic peptide containing tyrosine residues that inhibit AMPAR endocytosis and is effective in the research of long-term depression (LTD) .

HY-P4106A

Tat-GluR23Y, scrambled TFA	Amino Acid Derivatives	Neurological Disease
Tat-GluR23Y, scrambled TFA is the scrambled peptide of Tat-GluR23Y (HY-P2259). Tat-GluR23Y is a synthetic peptide containing tyrosine residues that inhibit AMPAR endocytosis and is effective in the research of long-term depression (LTD) .

HY-P2262A

TAT-DEF-Elk-1 TFA TDE TFA	Peptides	Neurological Disease
TAT-DEF-Elk-1 TFA (TDE TFA) is a cell-penetrating peptide inhibitor of Elk-1, mimics and specifically interferes with the DEF domain of Elk-1. TAT-DEF-Elk-1 TFA blocks Elk-1 phosphorylation and prevents Elk-1 nuclear translocation without interfering with ERK nor MSK1 activation. TAT-DEF-Elk-1 TFA is a useful tool to analyze the role of Elk-1 in this process during the development of neuronal plasticity .

HY-P2497

Exendin (5-39) 1 Publications Verification	GCGR	Neurological Disease
Exendin (5-39) is a potent glucagon-like peptide 1 (GLP-1) receptor antagonist. Exendin (5-39) improves memory impairment in β-amyloid protein-treated rats .

HY-P2262

TAT-DEF-Elk-1 1 Publications Verification TDE	Peptides	Neurological Disease
TAT-DEF-Elk-1 (TDE) is a cell-penetrating peptide inhibitor of Elk-1, mimics and specifically interferes with the DEF domain of Elk-1. TAT-DEF-Elk-1 blocks Elk-1 phosphorylation and prevents Elk-1 nuclear translocation without interfering with ERK nor MSK1 activation. TAT-DEF-Elk-1 is a useful tool to analyze the role of Elk-1 in this process during the development of neuronal plasticity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113323

3-Methoxy-4-hydroxyphenylglycol HMPG; MHPG; MOPEG	Structural Classification Monophenols Neurological Disease Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
3-Methoxy-4-hydroxyphenylglycol (HMPG) is a metabolite of norepinephrine degradation in the brain. 3-Methoxy-4-hydroxyphenylglycol is an indicators of central nervous system noradrenergic activity. 3-Methoxy-4-hydroxyphenylglycol can be used for research of depression, chronic schizophrenia, etc .

HY-N6057

Obtusin	Seeds of Cassia tora Linn. Quinones other families Leguminosae Anthraquinones Source classification Phenols Polyphenols Plants	Monoamine Oxidase
Obtusin, isolated from Cassia obtusifolia Linn seed, is a highly selective and competitive human monoamine oxidase-A (hMAO-A) inhibitor with an IC₅₀ of 11.12 μM and a K_i of 6.15 μM. Obtusin plays a preventive role in neurodegenerative diseases, especially anxiety and depression .

HY-14258

Escitalopram 3 Publications Verification (S)-Citalopram; (S)-(+)-Citalopram	Natural Products Source classification Endogenous metabolite	Serotonin Transporter
Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression .

HY-N0505

Rosiridin	Other Monoterpenes Rhodiola rosea Linn. Terpenoids Source classification Crassulaceae Plants	Monoamine Oxidase
Rosiridin inhibits MAO A and MAO B with potential beneficial effect in depression and senile dementia. Rosiridin shows an inhibition of 83.8% against MAO B at 10 μM (pIC₅₀=5.38) .

HY-N10378

Rubrofusarin 6-O-β-D-glucopyranoside	Monophenols Classification of Application Fields Neurological Disease Cassia obtusifolia L. Source classification Phenols Metabolic Disease Caesalpiniaceae Plants Disease Research Fields	Phosphatase
Rubrofusarin 6-O-β-D-glucopyranoside, the glycoside of Rubrofusarin, is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with the IC₅₀ of 87.36 μM. Rubrofusarin 6-O-β-D-glucopyranoside can be used for the research of comorbid diabetes and depression .

HY-N7506

13-Hydroxyisobakuchiol Delta3,2-Hydroxylbakuchiol	Structural Classification Monophenols Leguminosae Source classification Phenols Psoralea corylifolia L. Plants	Monoamine Transporter Dopamine Transporter
Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) isolated from Psoralea corylifolia (L.), is a potent monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC₅₀=0.58 μM) and norepinephrine transporter (NET) (IC₅₀=0.69 μM) than for the serotonin transporter (SERT) (IC₅₀=312.02 μM). 13-Hydroxyisobakuchiol has the potential for the research of disorders such as Parkinson's disease and depression .

HY-B1232

Metyrapone 5 Publications Verification Su-4885	Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Endocrinology Cancer	Endogenous Metabolite Cytochrome P450 Autophagy
Metyrapone (Su-4885) is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone can be used for researching Cushing's syndrome and depression .

HY-N4097

Incensole	other families Terpenoids Source classification Diterpenoids Plants	Others
Incensole, a 14-membered diterpenoid, is isolated from both essential oils and resins of frankincense. Incensole has shown anti-inflammatory and anti-depression activities due to their ability to activate ion channels in the brain to alleviate anxiety or depression .

HY-B1232A

Metyrapone Tartrate Su-4885 Tartrate	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite Cytochrome P450 Autophagy mTOR
Metyrapone (Su-4885) Tartrate is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone Tartrate inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone Tartrate increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone Tartrate can be used for researching Cushing's syndrome and depression .

HY-N12018

Isomaltopaeoniflorin	Structural Classification Polysaccharides Paeonia lactiflora Pall. Source classification Plants Paeoniaceae Saccharides	Others
Isomaltopaeoniflorin is a metabolite of the Chinese herbal formula Shuyu. Shuyu is a depression-like disease inhibitor .

HY-B1028

Pantethine 1 Publications Verification D-Pantethine; LBF disulfide	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite SARS-CoV
Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration .

HY-N3182

N-Methylnuciferine	Alkaloids other families Source classification Quinoline Alkaloids Plants	Others
N-Methylnuciferine, an alkaloid from Lotus Plumule, ameliorate lipopolysaccharide-induced depression-like behavior .

HY-N3297

Meranzin hydrate 1 Publications Verification	Cardiovascular Disease Neurological Disease Classification of Application Fields Source classification Rutaceae Coumarins Phenylpropanoids Plants Disease Research Fields Murraya exotica L. Mant.	Others
Meranzin hydrate, an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS), possess anti-depression and anti-atherosclerosis effects .

HY-W050031

(S)-3-Hydroxybutanoic acid 1 Publications Verification (S)-β-Hydroxybutanoic acid; L-(+)-3-Hydroxybutyric acid; L-β-Hydroxybutyric acid	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(S)-3-Hydroxybutanoic acid is a normal human metabolite, that has been found elevated in geriatric patients remitting from depression. In humans, 3-Hydroxybutyric acid is synthesized in the liver from acetyl-CoA, and can be used as an energy source by the brain when blood glucose is low.

HY-N2554

Osthenol Ostenol	Isodon excisoides (Sun ex C. H. Hu) H. Hara Source classification Coumarins Phenols Polyphenols Phenylpropanoids Plants Umbelliferae	Monoamine Oxidase
Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (K_i=0.26 µM). Osthenol potently inhibits recombinant hMAO-A with an IC₅₀ of 0.74 µM and shows a high selectivity index for hMAO-A versus hMAO-B .

HY-125740

Malvidin-3-glucoside chloride Malvidin-3-O-glucoside chloride; Oenin chloride	Structural Classification Classification of Application Fields Source classification Vitis vinifera cv. Zalema Plants Vitaceae Anthocyans Flavonoids Sunscreen Phenols Polyphenols Cosmetic Research Inflammation/Immunology Disease Research Fields	Others
Malvidin-3-glucoside chloride (Malvidin-3-O-glucoside chloride), a major wine anthocyanin, is effective in promoting resilience against stress by modulating brain synaptic plasticity and peripheral inflammation .

HY-118620

Nortriptyline 2 Publications Verification Desmethylamitriptyline; Desitriptilina	Alkaloids Neurological Disease Classification of Application Fields Centaurea bracteata Scop. Other Alkaloids Labiatae Source classification Plants Disease Research Fields Cancer	Autophagy Drug Metabolite Apoptosis
Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects . N

HY-N3298

Meranzin	Cardiovascular Disease other families Classification of Application Fields Neurological Disease Source classification Coumarins Phenylpropanoids Plants Disease Research Fields	Adrenergic Receptor
Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression .

HY-116330

Hyperforin	Structural Classification Anti-inflammation/Immunoregulatory Antibiotics Source classification Guttiferae Hyperlcurn perforatum L. Disease Research Plants Anticancer	Calcium Channel TRP Channel
Hyperforin is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin modulates Ca ²⁺ levels by activating Ca ²⁺-conducting non-selective canonical TRPC6 channels. Hyperforin also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model .

HY-116330A

Hyperforin dicyclohexylammonium salt 1 Publications Verification Hyperforin DCHA	Structural Classification Natural Products Source classification Guttiferae Hyperlcurn perforatum L. Plants	TRP Channel Calcium Channel
Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca ²⁺ levels by activating Ca ²⁺-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin dicyclohexylammonium salt modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model .

Cat. No.	Product Name	Chemical Structure

HY-U00050S

(E)-10-Hydroxynortriptyline-d3
(E)-10-Hydroxynortriptyline-d₃ is a deuterium labeled (E)-10-Hydroxy Nortriptyline. (E)-10-Hydroxy Nortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1].

HY-B1417S

Nortriptyline-d3 hydrochloride
Nortriptyline-d₃ (hydrochloride) is the deuterium labeled Nortriptyline hydrochloride. Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and used to relieve the symptoms of depression[1].

HY-100646AS

(Z)-10-Hydroxynortriptyline-d3
(Z)-10-Hydroxynortriptyline-d₃ is the deuterium labeled (Z)-10-Hydroxynortriptyline (HY-100646A). (Z)-10-Hydroxynortriptyline is a metabolite of Nortriptyline (HY-118620). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1][2].

HY-14258AS

Escitalopram-d6 oxalate

Escitalopram-d₆ (oxalate) is the deuterium labeled Escitalopram oxalate. Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression[1][2].

HY-14258AS1

Escitalopram-d4 oxalate

Escitalopram-d₄ (oxalate) is deuterium labeled Escitalopram (oxalate). Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression[1][2].

HY-90003S

Tianeptine-d12
Tianeptine-d12 is a deuterated analog of Tianeptine. Tianeptine is an antidepressant with oral activity and neurochemical properties. Tianeptine has neuroprotective effects against hypoxia in tissue culture and against the deleterious effects of cytokines in the cortex and white matter, but not against NMDA receptor-mediated excitotoxicity .

HY-17447AS

(1S,2R)-Tranylcypromine-d5 hydrochloride

(1S,2R)-Tranylcypromine-d₅ (hydrochloride) is the deuterium labeled Tranylcypromine hydrochloride[1]. Tranylcypromine hydrochloride (SKF 385 hydrochloride) is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Tranylcypromine hydrochloride inhibits LSD1, MAO A and MAO B with IC50s of 20.7, 2.3 and 0.95 μM, respectively. Tranylcypromine hydrochloride can be used for the research of depression[2][3][4].

HY-B0457S1

Clomipramine-d6 hydrochloride
Clomipramine-d₆ (hydrochloride) is the deuterium labeled Clomipramine hydrochloride. Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD)[1].

HY-B0949S

Protriptyline (N-methyl-d3) (hydrochloride)
Protriptyline (N-methyl-d₃) (hydrochloride) is the deuterium labeled Protriptyline hydrochloride. Protriptyline hydrochloride is a tricyclic antidepressant (TCA), specifically a secondary amine, for the treatment of depression and ADHD. Unique among the TCAs, protriptyline tends to be energizing instead of sedating, used for narcolepsy to achieve a wakefulness-promoting effect[1].

HY-B0457S2

Clomipramine-13C,d3 hydrochloride
Clomipramine- ¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled Clomipramine (hydrochloride). Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD)[1].

HY-17447SA

Tranylcypromine-d5 hydrochloride

Tranylcypromine-d₅ (hydrochloride) is a deuterium labeled (rel)-Tranylcypromine hydrochloride. Tranylcypromine hydrochloride is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hydrochloride is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis[1][2].

HY-B1028S

Pantethine-15N2

Pantethine- ¹⁵N₂ is the ¹⁵N₂ labeled Pantethine. Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration .

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