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Development Inhibitors

" in MedChemExpress (MCE) Product Catalog:

195

Inhibitors & Agonists

20

Screening Libraries

3

Biochemical Assay Reagents

22

Peptides

29

Natural
Products

13

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W013812

    Linoleic Acid ethyl ester; Mandenol

    Others Cardiovascular Disease
    Ethyl linoleate (Linoleic Acid ethyl ester) inhibit the development of atherosclerotic lesions and the expression of inflammatory mediators .
    Ethyl linoleate
  • HY-W010538

    Parasite Infection
    trans-4-Methylcyclohexanamine is an intermediate and can be used for the development of T. cruzi enzyme inhibitor .
    trans-4-Methylcyclohexanamine
  • HY-103663A

    Histone Methyltransferase Cancer
    MAK683 hydrochloride is an embryonic ectoderm development (EED) inhibitor extracted from patent US20160176882 A1, compound example 2. MAK683 exhibits IC50s of 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay .
    MAK683 hydrochloride
  • HY-N9599

    Others Others
    Roridin A is an inhibitor of pollen development in Arabidopsis thaliana. Roridin A is isolated from the fungus Cylindrocarpon sp. Roridin A inhibits the pollen development at concentrations of 2 μM .
    Roridin A
  • HY-B2063

    Chlorobenzuron is a chitin synthetase inhibitor, acts as an insecticide. Chlorobenzuron can inhibit larvae development and pupate .
    Chlorobenzuron
  • HY-121161A
    Brassinazole
    1 Publications Verification

    Others Others
    Brassinazole is a selective triazole-type brassinosteroid (BR) biosynthesis inhibitor. Brassinazole is used for regulating plant growth and development .
    Brassinazole
  • HY-Y0079

    Endogenous Metabolite Others
    D-Phenylalanine is the synthetic dextro isomer of phenylalanine. D-Phenylalanine inhibits biofilm development of Pseudoalteromonas sp. SC2014 .
    D-Phenylalanine
  • HY-153921

    Dengue virus Infection
    DEPN-8 is a WNV protease substrate. DEPN-8 is used for dengue virus protease inhibitor development .
    DEPN-8
  • HY-B2009

    Flufenoxuron is a chitin synthesis inhibitor that is used as a benzoylurea insecticide. Flufenoxuron decreases chitin synthesis, molting, and egg hatching, preventing development in insects .
    Flufenoxuron
  • HY-W004546

    MMP Parasite Infection
    Abametapir is a metalloproteinase (MMP) inhibitor which is able to target metalloproteinases critical to egg hatching and louse development. Abametapir can inhibit hatching of both head and body louse .
    Abametapir
  • HY-N8579

    Others Inflammation/Immunology
    Eugenyl benzoate has the potency for scavenging of DPPH radical. Eugenyl Benzoate Derivatives can be used for development of BCL-2 inhibitors .
    Eugenyl benzoate
  • HY-147553

    HIV Infection
    HIV-1 inhibitor-36 (Compound 2) is a potent HIV-1. HIV-1 inhibitor-36 has the potential for further development as novel latency reversing agents .
    HIV-1 inhibitor-36
  • HY-147554

    HIV Infection
    HIV-1 inhibitor-37 (Compound 83) is a potent HIV-1. HIV-1 inhibitor-37 has the potential for further development as novel latency reversing agents .
    HIV-1 inhibitor-37
  • HY-147555

    HIV Infection
    HIV-1 inhibitor-38 (Compound 91) is a potent HIV-1. HIV-1 inhibitor-38 has the potential for further development as novel latency reversing agents .
    HIV-1 inhibitor-38
  • HY-149004B

    LPL Receptor Inflammation/Immunology
    SLF1081851 (hydrochloride) is a Spns2 inhibitor, inhibits S1P release (IC50=1.93 μM). SLF1081851 (hydrochloride) plays a key role in the development and immune system .
    SLF1081851 hydrochloride
  • HY-11067
    WHI-P97
    2 Publications Verification

    JAK Inflammation/Immunology
    WHI-P97 is a potent and selective JAK-3 inhibitor. WHI-P97 is effective in preventing the development allergic asthma in vivo .
    WHI-P97
  • HY-100365

    SHP-141

    Remetinostat (SHP-141) is a hydroxamic acid-based inhibitor of histone deacetylase enzymes (HDAC) which is under development for the treatment of cutaneous T-cell lymphoma .
    Remetinostat
  • HY-108522
    PA452
    1 Publications Verification

    RAR/RXR Metabolic Disease
    PA452, retinoic X receptor (RXR) specific antagonist, inhibits the effect of Retinoic acid (RA) on Th1/Th2 development .
    PA452
  • HY-W013812S

    Linoleic Acid-13C18 ethyl ester; Mandenol-13C18

    Isotope-Labeled Compounds Cardiovascular Disease
    Ethyl linoleate- 13C18 is the 13C labeled Ethyl linoleate. Ethyl linoleate inhibit the development of atherosclerotic lesions and the expression of inflammatory mediators[1].
    Ethyl linoleate-13C18
  • HY-N7229

    DNA/RNA Synthesis Cancer
    Rabdosin B is an ent-kaurene diterpenoid with anticancer effects. Rabdosin B induces DNA damage in cells, and inhibits lettuce root hair development of seedlings .
    Rabdosin B
  • HY-149943

    Others Inflammation/Immunology
    PAP-IN-2 (Compound 35) is a purple acid phosphatase (PAP) inhibitor (Kis: 186 nM). PAP-IN-2 can be used for development of anti-osteoporotic compounds .
    PAP-IN-2
  • HY-149004
    SLF1081851
    1 Publications Verification

    LPL Receptor Inflammation/Immunology
    SLF1081851 is a Spns2 inhibitor, inhibits S1P release (IC50=1.93 μM). SLF1081851 plays a key role in development and immune system .
    SLF1081851
  • HY-B0941
    6-Benzylaminopurine
    3 Publications Verification

    Benzyladenine; 6-BAP; N6-Benzyladenine

    Endogenous Metabolite Others
    6-Benzylaminopurine (Benzyladenine) is the first cytokinin that causes plant growth and development by stimulating cell division and inhibiting respiratory kinases, thereby prolonging the preservation of green vegetables .
    6-Benzylaminopurine
  • HY-112540B
    Acetoacetic acid sodium
    2 Publications Verification

    Endogenous Metabolite Metabolic Disease
    Acetoacetic acid sodium is a metabolite of non-esterified fatty acids, involved in the development of human diabetes. Acetoacetic acid sodium induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes .
    Acetoacetic acid sodium
  • HY-149004A

    LPL Receptor Inflammation/Immunology
    SLF1081851 (TFA) is a Spns2 inhibitor, inhibits S1P release (IC50=1.93 μM). SLF1081851 (TFA) plays a key role in development and immune system .
    SLF1081851 TFA
  • HY-126320

    EGFR c-Met/HGFR Cancer
    EGFR-IN-8 is a dual EGFR and c-Met inhibitor, compound 48. EGFR-IN-8 can be a promising candidate for further development to target EGFR TKI-resistant NSCLC .
    EGFR-IN-8
  • HY-109582
    ADT-OH
    1 Publications Verification

    5-(4-Hydroxyphenyl)-3H-1,2-dithiole-3-thione; ACS 1

    Apoptosis Cancer
    ADT-OH is a hydrogen sulfide-releasing donor. ADT-OH induces apoptosis and inhibits the development of melanoma in vivo by upregulating FADD. ADT-OH has the potential for the research of cancer diseases .
    ADT-OH
  • HY-117878

    Others Metabolic Disease
    ML345 is a potent and selective insulin-degrading enzyme (IDE) small-molecule inhibitor, with an IC50 value of 188 nM. ML345 can be for use as a pharmacophore for agent development in diabetes research .
    ML345
  • HY-147643

    Aminoacyl-tRNA Synthetase Infection
    Aminoacyl tRNA synthetase-IN-2 (Compound 14) is an aminoacyl-tRNA synthetase (aaRS) inhibitor. Aminoacyl tRNA synthetase-IN-2 can be used for development of a new family of antibiotics .
    Aminoacyl tRNA synthetase-IN-2
  • HY-B2227C

    Lactic acid potassium

    Bacterial Infection Others
    Lactate (Lactic acid) potassium is used as a sodium chloride substitute in the elaboration of dry meat products. Lactate potassium (56%) and sodium diacetate (4%) mixture inhibit the development of L. sake and L. monocytogenes bacteria at 4℃ to extend the shelf life of food .
    Lactate potassium
  • HY-131923

    Notch Cancer
    DAPM is a Notch pathway inhibitor with anticancer activity and antiproliferative effects. DAPM effectively inhibits tubular adenoma development by inhibiting cell proliferation and inducing the expression of Krüppel-like factor 4 (KLF4) and p21 in human colon cancer cells .
    DAPM
  • HY-N12210

    Parasite Others
    Notrilobolide is an alkaloid with insecticidal properties isolated from sweet potatoes. Notrilobolide has an inhibitory effect on the larval development of pests such as Tribolium Castaneum, affecting the digestion and reproduction of insects by inhibiting the fecundity of pests .
    Notrilobolide
  • HY-A0096
    Iloprost
    3 Publications Verification

    Ciloprost; ZK 36374

    Prostaglandin Receptor Endogenous Metabolite Endocrinology Cancer
    Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research .
    Iloprost
  • HY-118047

    Nucleoside Antimetabolite/Analog Inflammation/Immunology
    CI 972 anhydrous is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent .
    CI 972 anhydrous
  • HY-Y0079S

    Endogenous Metabolite Others
    D-Phenylalanine-d5 is the deuterium labeled D-Phenylalanine. D-Phenylalanine is the synthetic dextro isomer of phenylalanine. D-Phenylalanine inhibits biofilm development of Pseudoalteromonas sp. SC2014[1].
    D-Phenylalanine-d5
  • HY-Y0079S1

    Isotope-Labeled Compounds Endogenous Metabolite
    D-Phenylalanine-d8 is the deuterium labeled D-Phenylalanine. D-Phenylalanine is the synthetic dextro isomer of phenylalanine. D-Phenylalanine inhibits biofilm development of Pseudoalteromonas sp. SC2014[1].
    D-Phenylalanine-d8
  • HY-18572S

    2,4-Dichlorophenoxyacetic acid-13C6

    Isotope-Labeled Compounds DNA/RNA Synthesis Others
    2,4-D- 13C6 is the 13C-labeled 2,4-D. 2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development[1].
    2,4-D-13C6
  • HY-18572S1

    DNA/RNA Synthesis Others
    2,4-D-d3 is the deuterium labeled 2,4-D[1]. 2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development[2].
    2,4-D-d3
  • HY-18572S2

    DNA/RNA Synthesis Others
    2,4-D-d5 is the deuterium labeled 2,4-D[1]. 2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development[2].
    2,4-D-d5
  • HY-50935
    Troglitazone
    15+ Cited Publications

    CS-045

    PPAR Autophagy Apoptosis Ferroptosis Metabolic Disease Cancer
    Troglitazone is an orally active PPARγ agonist, with EC50s of 550 nM and 780 nM for human and murine PPARγ receptor, respectively. Troglitazone has anticancer activity, prevents and inhibits the development of type 2 diabetes.
    Troglitazone
  • HY-136977

    Histone Methyltransferase Cancer
    EEDi-5285 is an exceptionally potent and orally active embryonic ectoderm development (EED) inhibitor with an IC50 value of 0.2 nM for binds to the EED protein. EEDi-5285 has anti-cancer activity .
    EEDi-5285
  • HY-N10190

    Parasite Endogenous Metabolite Infection
    Asperaculane B is a fungal metabolite against P. falciparum transmission with an IC50 of 7.89 µM. Asperaculane B also inhibits the development of asexual P. falciparum with IC50 of 3 µM, and it is nontoxic to human cells .
    Asperaculane B
  • HY-114080

    E-3123

    Ser/Thr Protease Inflammation/Immunology
    Patamostat (E-3123) is a potent protease inhibitor. Patamostat potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat may possess suppressing effects on pathogenesis and development of acute pancreatitis .
    Patamostat
  • HY-114080A

    E-3123 mesylate

    Ser/Thr Protease Inflammation/Immunology
    Patamostat (E-3123) mesylate is a potent protease inhibitor. Patamostat mesylate potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat mesylate may possess suppressing effects on pathogenesis and development of acute pancreatitis .
    Patamostat mesylate
  • HY-128337

    Parasite Infection
    AN7973 is the 6-carboxamide benzoxaborole, blocks intracellular parasite development and inhibits Cryptosporidium growth. AN7973 is orally active, possesses favorable safety, stability, and PK parameters, and is an exciting agent candidate for treating cryptosporidiosis.
    AN7973
  • HY-144420

    Influenza Virus Infection
    Neuraminidase-IN-5 (Compound 5b) is a potent inhibitor of neuraminidase with an IC50 of 0.02 μM. Neuraminidase (NA) is a promising target for development of anti-influenza agents. Neuraminidase-IN-5 is a dihydrofurocoumarin derivative compound .
    Neuraminidase-IN-5
  • HY-144278

    Bacterial Infection Inflammation/Immunology
    Anti-MRSA agent 1 (Compound 13d) is a wonderful MRSA (MIC = 0.5 μg/mL) inhibitor. Anti-MRSA agent 1 (Compound 13d) could effectually relieve the development of MRSA resistance .
    Anti-MRSA agent 1
  • HY-50667
    Apixaban
    5+ Cited Publications

    BMS-562247-01

    Factor Xa Cardiovascular Disease
    Apixaban (BMS-562247-01) is a highly selective, reversible and orally active inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively . Apixaban is in development for the prevention and treatment of various thromboembolic diseases .
    Apixaban
  • HY-N6845

    DNA/RNA Synthesis Cancer
    3-Isomangostin, extracted from Garciniamangostana.L. shell, is a potent MutT homologue 1 (MTH1) inhibitor with an IC50 value of 52 nM. 3-Isomangostin would be an attractive chemical tool for the development of anticancer agents .
    3-Isomangostin
  • HY-136307S

    Parasite Infection
    Tizoxanide-d4 glucuronide is the deuterium labeled Tizoxanide glucuronide. Tizoxanide glucuronide is the metabolite of Nitazoxanide (HY-B0217) and is cell-permeable to inhibit asexual and sexual stages development of parasite C. parvum[1].
    Tizoxanide-d4 glucuronide

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