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Results for "

Dopamine Receptor

" in MCE Product Catalog:

By Targets:	Dopamine Receptor (295) Dopamine Transporter (1) 5-HT Receptor (121) Adenosine Receptor (1) Adenylate Cyclase (2) Adrenergic Receptor (41) Akt (1) Amyloid-β (2) Apoptosis (10) Arrestin (3) Autophagy (12) Bacterial (13) Calcium Channel (4) Chloride Channel (1) Cholinesterase (ChE) (1) Drug Metabolite (9) Dynamin (2) Endogenous Metabolite (2) GABA Receptor (1) Histamine Receptor (25) iGluR (4) Influenza Virus (1) Isotope-Labeled Compounds (6) mAChR (16) Microtubule/Tubulin (1) Mitophagy (2) nAChR (4) Neurokinin Receptor (1) Opioid Receptor (4) P-glycoprotein (4) Parasite (3) Phosphodiesterase (PDE) (1) Phospholipase (1) PI3K (2) Potassium Channel (4) SARS-CoV (2) Serotonin Transporter (3) Sigma Receptor (8) Sodium Channel (8) Somatostatin Receptor (1) STAT (4) Trk Receptor (3)
By Research Areas:	Cancer (31) Cardiovascular Disease (4) Endocrinology (21) Infection (12) Inflammation/Immunology (11) Metabolic Disease (7) Neurological Disease (331)

By Targets:

Dopamine Receptor (295)

Dopamine Transporter (1)

5-HT Receptor (121)

Adenosine Receptor (1)

Adenylate Cyclase (2)

Adrenergic Receptor (41)

Akt (1)

Amyloid-β (2)

Apoptosis (10)

Arrestin (3)

Autophagy (12)

Bacterial (13)

Calcium Channel (4)

Chloride Channel (1)

Cholinesterase (ChE) (1)

Drug Metabolite (9)

Dynamin (2)

Endogenous Metabolite (2)

GABA Receptor (1)

Histamine Receptor (25)

iGluR (4)

Influenza Virus (1)

Isotope-Labeled Compounds (6)

mAChR (16)

Microtubule/Tubulin (1)

Mitophagy (2)

nAChR (4)

Neurokinin Receptor (1)

Opioid Receptor (4)

P-glycoprotein (4)

Parasite (3)

Phosphodiesterase (PDE) (1)

Phospholipase (1)

PI3K (2)

Potassium Channel (4)

SARS-CoV (2)

Serotonin Transporter (3)

Sigma Receptor (8)

Sodium Channel (8)

Somatostatin Receptor (1)

STAT (4)

Trk Receptor (3)

By Research Areas:

Cancer (31)

Cardiovascular Disease (4)

Endocrinology (21)

Infection (12)

Inflammation/Immunology (11)

Metabolic Disease (7)

Neurological Disease (331)

350

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Dopamine Receptor Dopamine Transporter Dopamine β-hydroxylase

Cat. No.	Product Name	Target	Research Areas

HY-115953

Dopamine D3 receptor ligand-1	Dopamine Receptor	Neurological Disease
Dopamine D₃ receptor ligand is a potent, selective and high affinity ligand for Dopamine D₃ receptor with 89-fold selective for D₃ over D₂ (D₃ K_i= 8 nM, D₂ K_i= 715 nM).

HY-147398

Dopamine D4 receptor antagonist-1	Dopamine Receptor	Neurological Disease
Dopamine D4 receptor antagonist-1 is a selective DRD4 antagonists, with a K_i of 9.0 nM for Hd4.2. Dopamine D4 receptor antagonist-1 can be used in study of schizophrenia.

HY-151515

Dopamine D2 receptor agonist-2	Dopamine Receptor	Neurological Disease
Dopamine D2 receptor agonist-2 (compound 36) is a potent **dopamine D₂ receptor biased agonism ligand with an K_i** value of 11.2 nM. Dopamine D2 receptor agonist-2 can be used to research antipsychosis.

HY-129946

Dopamine D2 receptor antagonist-1	Dopamine Receptor	Neurological Disease
Dopamine D2 receptor antagonist-1 is a negative allosteric modulator (NAM) of the dopamine D2 receptor (D2R) with sub-mM affinity.

HY-115968

Dopamine D3 receptor ligand-4	Dopamine Receptor	Neurological Disease
Dopamine D3 receptor ligand-4 (compound 6) is a potent and selective **dopamine D₃ receptor ligand, with a K_i** of 0.5 nM. Dopamine D3 receptor ligand-4 shows high level of selectivity for D₃ over D₂ (K_i=7.43 nM).

HY-139680

Dopamine D3 receptor antagonist-1	Dopamine Receptor	Neurological Disease
Dopamine D3 receptor antagonist-1 is a **dopamine D₃ receptor**-selective or multitarget bitopic ligand (K_i = 1.58 nM) potentially useful for central nervous system disorders.

HY-139681

Dopamine D3 receptor antagonist-2	Dopamine Receptor	Neurological Disease
Dopamine D3 receptor antagonist-2 is a **dopamine D3 receptor**-selective (K_i = 2.16 nM) or multitarget bitopic ligand potentially useful for central nervous system disorders.

HY-115955

Dopamine D3 receptor ligand-3	Dopamine Receptor	Neurological Disease
Dopamine D3 receptor ligand-3 (compound 12C) is a potent D₃ receptor ligand with a K_i of 3.6 nM. Dopamine D3?receptor ligand-3 have high selectivity for D₃ over D₂ (K_i=353 nM).

HY-115954

Dopamine D3 receptor ligand-2	Dopamine Receptor	Neurological Disease
Dopamine D3 receptor ligand-2 (compound 8) is a potent D₃ receptor ligand with a K_i of 11.4 nM. Dopamine D3 receptor ligand-2 have high selectivity for D₃ over D₂ (K_i=1228 nM).

HY-103427

NPEC-caged-dopamine	Dopamine Receptor	Neurological Disease
NPEC-caged-dopamine is a caged version of dopamine. NPEC-caged-Dopamine was used by applying focal photolysis with UV light (360 nm) to releases dopamine, which leads to D1 receptor activation.

HY-75502

Rotigotine N-0437; N-0923	Dopamine Receptor Adrenergic Receptor 5-HT Receptor	Neurological Disease Endocrinology
Rotigotine is a potent **dopamine receptor agonist with K_i** values of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors and dopamine D1 receptor. Rotigotine a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor. Rotigotine can be used for parkinson's disease (PD) research.

HY-108237

Naxagolide (+)-PHNO; Dopazinol	Dopamine Receptor	Neurological Disease
Naxagolide ((+)-PHNO; Dopazinol) is a potent dopamine D2 (Dopamine *Receptor*) agonist. Naxagolide has the potential for the research of parkinson's disease (PD).

HY-141495A

Razpipadon (-)-PW0464	Dopamine Receptor	Neurological Disease
Razpipadon ((-)-PW0464), an aromatic compound, is a **dopamine receptor** partial agonist. Razpipadon can be used in the study of dopamine D1 ligand-mediated related psychiatric disorders.

HY-A0125

Alizapride
Dopamine Receptor Neurological Disease

Alizapride is a potent antiemetic, acting as a dopamine receptor antagonist. Alizapride also used in human digestive disorders.

Alizapride	Dopamine Receptor	Neurological Disease
Alizapride is a potent antiemetic, acting as a **dopamine receptor** antagonist. Alizapride also used in human digestive disorders.

HY-W040146

Propionylpromazine hydrochloride Propiopromazine hydrochloride	Dopamine Receptor	Neurological Disease
Propionylpromazine hydrochloride (Propiopromazine hydrochloride), a dopamine receptor D2 (DRD2) antagonist, can be used in the research of Parkinson disease.

HY-115553

DETQ	Dopamine Receptor	Neurological Disease
DETQ is a selective, allosteric and orally active **dopamine D1 receptor (Dopamine Receptor*) potentiator. In HEK293 cells expressing the human D1 receptor, DETQ increases cAMP with an EC₅₀* of 5.8 nM and a K_b of 26 nM. DETQ shows ~30-fold less potent at rat and mouse D1 receptors and is inactive at the human D5 receptor.

HY-101348

L-741626	Dopamine Receptor	Neurological Disease
L-741626 is a selective D2 dopamine receptor antagonist, with the K_i values of 2.4, 100 and 220 nM for human D2, D3 and D4 receptors respectively.

HY-42849

Sultopride
LIN-1418
Dopamine Receptor Neurological Disease

Sultopride (LIN-1418) is a selective antagonist of dopamine D2 receptor.

Sultopride LIN-1418	Dopamine Receptor	Neurological Disease
Sultopride (LIN-1418) is a selective antagonist of **dopamine D2 receptor**.

HY-42849A

Sultopride hydrochloride LIN-1418 hydrochloride	Dopamine Receptor	Neurological Disease
Sultopride hydrochloride (LIN-1418 hydrochloride) is a selective antagonist of **dopamine D2 receptor**.

HY-12237

SKF 38393 hydrobromide (±)-SKF-38393 hydrobromide	Dopamine Receptor	Neurological Disease
SKF 38393 ((±)-SKF-38393) hydrobromide is a selective agonist of the dopamine D1 receptor (D1DR) with an IC₅₀ of 110 nM.

HY-103413

Eticlopride hydrochloride	Dopamine Receptor	Neurological Disease
Eticlopride hydrochloride, a selective dopamine D2‐like receptor antagonist, exhibits high affinity for dopamine D2, α1‐adrenergic, α2‐adrenergic, 5HT1, 5HT2 receptors with K_is of 0.09, 112, 699, 6220, and 830 nM, respectively. Antipsychotic agent.

HY-10847A

SB-277011 dihydrochloride SB-277011A dihydrochloride	Dopamine Receptor	Neurological Disease
SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate **dopamine D₃ receptor antagonist, with pK_i*s of 8.0, 6.0, <5.2 and 5.9 for D₃, D₂, 5-HT_1B, and 5-HT_1D receptors*, respectively.

HY-101299A

Dihydrexidine DAR-0100	Dopamine Receptor	Neurological Disease
Dihydrexidine (DAR-0100) is a high potent, selective and full efficacy *D1-like dopamine* receptor (D1/D5) agonist with an IC₅₀** of 10 nM for D1 receptor. Dihydrexidine exhibits potent antiparkinsonian activity. Dihydrexidine can stimulate YAP phosphorylation.

HY-101299B

Dihydrexidine hydrochloride DAR-0100 hydrochloride	Dopamine Receptor	Neurological Disease
Dihydrexidine hydrochloride (DAR-0100 hydrochloride) is a high potent, selective and full efficacy *D1-like dopamine* receptor (D1/D5) agonist, with an IC₅₀** of 10 nM for D1 receptor. Dihydrexidine hydrochloride exhibits potent antiparkinsonian activity. Dihydrexidine hydrochloride can stimulate YAP phosphorylation.

HY-19733

Lumateperone tosylate ITI-007 tosylate	5-HT Receptor Dopamine Receptor	Neurological Disease
Lumateperone (ITI-007) tosylate is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone tosylate has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia.

HY-17637

Lumateperone ITI-007	Dopamine Receptor 5-HT Receptor	Neurological Disease
Lumateperone (ITI-007) is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia.

HY-W014728

N-Methyldopamine hydrochloride	Dopamine Receptor	Neurological Disease Cardiovascular Disease
N-Methyldopamine hydrochloride is a precursor of adrenaline in the adrenal medulla. N-Methyldopamine hydrochloride is a modification of the dopamine (DA), and retains agonist activity at the DA1 receptor. N-Methyldopamine hydrochloride remains capable of universal surface coating and secondary reactions using the surface catechols. N-Methyldopamine hydrochloride can be used for heart failure research.

HY-101626A

Sigma-LIGAND-1 hydrochloride	Sigma Receptor	Neurological Disease
Sigma-LIGAND-1 hydrochloride is a selective sigma receptor ligand with an IC₅₀s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 hydrochloride has a K_i of 4000 nM at the dopamine D₂ receptor.

HY-101626

Sigma-LIGAND-1	Sigma Receptor	Neurological Disease
Sigma-LIGAND-1 is a selective sigma receptor ligand with an IC₅₀s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 has a K_i of 4000 nM at the dopamine D₂ receptor.

HY-103407A

PD 168568 dihydrochloride	Dopamine Receptor	Cancer Neurological Disease
PD 168568 dihydrochloride is a orally active and potent dopamine receptor D₄ (DRD₄) antagonist. PD 168568 dihydrochloride contains an isoindolinone and is selective for the D₄ receptor versus D₂ and D₃, with K_i values of 8.8, 1842, and 2682 nM, respectively. PD 168568 dihydrochloride can be used for glioblastoma (GBM) research.

HY-144291

LY3154885	Dopamine Receptor	Neurological Disease
LY3154885 is an orally active **dopamine D1 receptor** positive allosteric modulator (PAM). LY3154885 has an improved agent-agent interactions (DDI) risk profile.

HY-14325

L-745870	Dopamine Receptor	Neurological Disease
L-745870 is a potent, selective, brain-penetrant and orally active **dopamine D₄ receptor antagonist with a K_i of 0.43 nM. L-745870 shows weaker affinity for D₂ (K_i of 960 nM) and D₃ (K_i** of 2300 nM) receptors, and exhibits moderate affinity for 5-HT₂ receptors, sigma sites and α-adrenoceptors.

HY-14325B

L-745870 hydrochloride	Dopamine Receptor	Neurological Disease
L-745870 hydrochloride is a potent, selective, brain-penetrant and orally active **dopamine D₄ receptor antagonist with a K_i of 0.43 nM. L-745870 hydrochloride shows weaker affinity for D₂ (K_i of 960 nM) and D₃ (K_i** of 2300 nM) receptors, and exhibits moderate affinity for 5-HT₂ receptors, sigma sites and α-adrenoceptors.

HY-135147

ONC206	Dopamine Receptor	Cancer Neurological Disease
ONC206 is an analogue of TRAIL inducer ONC201. ONC206 is a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations. ONC206 has broad-spectrum anti-tumor activity.

HY-110080

Lisuride maleate	Dopamine Receptor	Neurological Disease
Lisuride (maleate) is a potent agonist of dopamine with a probably direct action on dopaminergic receptors. Lisuride (maleate) is an ergot derivative. Lisuride (maleate) releases the premenstrual mastalgia without significant side effects.

HY-116020

FAUC 365	Dopamine Receptor	Neurological Disease
FAUC 365 is a highly **dopamine D3 receptor**-selective antagonist with K_i values of 0.5 nM, 340, 2600, and 3600 nM at D3, D4.4, D2_short, and D2_Long receptors, respectively. FAUC 365 can be used for the research of schizophrenia, and Parkinson's disease.

HY-17407

Ziprasidone hydrochloride monohydrate CP 88059 hydrochloride monohydrate	5-HT Receptor Dopamine Receptor	Neurological Disease
Ziprasidone (CP-88059) hydrochloride monohydrate is an orally active combined 5-HT and *dopamine* receptor antagonist. Ziprasidone hydrochloride monohydrate has affinities for Rat D₂ (K_i=4.8 nM), 5-HT_2A (K_i=0.42 nM) and 5-HT_1A (K_i=3.4 nM).

HY-14542C

Ziprasidone mesylate CP-88059 mesylate	5-HT Receptor Dopamine Receptor	Neurological Disease
Ziprasidone (CP-88059) mesylate is an orally active combined 5-HT and *dopamine* receptor antagonist. Ziprasidone mesylate has affinities for Rat D₂ (K_i=4.8 nM), 5-HT_2A (K_i=0.42 nM) and 5-HT_1A (K_i=3.4 nM).

HY-14542

Ziprasidone CP-88059	5-HT Receptor Dopamine Receptor	Neurological Disease
Ziprasidone (CP-88059), an orally active antipsychotic agent, is a combined 5-HT and *dopamine* receptor antagonist. Ziprasidone mesylate trihydrate has affinities for Rat D₂ (K_i=4.8 nM), 5-HT_2A (K_i=0.42 nM) and 5-HT_1A (K_i=3.4 nM).

HY-14542B

Ziprasidone mesylate trihydrate CP-88059 mesylate trihydrate	5-HT Receptor Dopamine Receptor	Neurological Disease
Ziprasidone (CP-88059) mesylate trihydrate is an orally active combined 5-HT and *dopamine* receptor antagonist. Ziprasidone mesylate trihydrate has affinities for Rat D₂ (K_i=4.8 nM), 5-HT_2A (K_i=0.42 nM) and 5-HT_1A (K_i=3.4 nM).

HY-107663

MIF-1 Pro-Leu-Gly-NH2; Melanostatin	Dopamine Receptor	Neurological Disease
MIF-1 (Melanostatin), an endogenous brain peptide, is a potent **dopamine receptor** allosteric modulator. MIF-1 inhibits melanin formation. MIF-1 blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB).

HY-107663A

MIF-1 TFA Pro-Leu-Gly-NH2 TFA; Melanostatin TFA	Dopamine Receptor	Neurological Disease
MIF-1 TFA (Melanostatin), an endogenous brain peptide, is a potent **dopamine receptor** allosteric modulator. MIF-1 TFA inhibits melanin formation. MIF-1 TFA blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 TFA accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB).

HY-10121

Asenapine Org 5222	5-HT Receptor Adrenergic Receptor Dopamine Receptor Histamine Receptor	Neurological Disease Endocrinology
Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i: 8.9-9.5), **dopamine receptors (pK_i*: 8.9-9.4) and histamine receptors* (pK_i: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder.

HY-145308

Heterobivalent ligand-1	Adenosine Receptor Dopamine Receptor	Neurological Disease
Heterobivalent ligand-1 (compound 26) is a heterobivalent ligand for the Adenosine A 2A-dopamine D 2 receptor heteromer (K_DB1 A_2AR=2.1 nM, K_DB1 D₂R= 0.13 nM).

HY-B1240

Droperidol
Dehydrobenzperidol
Dopamine Receptor Neurological Disease

Droperidol is a Dopamine-2 Receptor Antagonist.
HY-U00077

Org-10490
Dopamine Receptor Neurological Disease

Org-10490 is an antagonist of dopamine D1 receptor and dopamine D2 receptor, used for the treatment for psychiatric disease.

Droperidol Dehydrobenzperidol	Dopamine Receptor	Neurological Disease
Droperidol is a Dopamine-2 Receptor Antagonist.

Org-10490	Dopamine Receptor	Neurological Disease
Org-10490 is an antagonist of **dopamine D1 receptor and dopamine D2 receptor**, used for the treatment for psychiatric disease.

HY-B1110

Nomifensine (±)-Nomifensin	Dopamine Receptor	Neurological Disease
Nomifensine is a norepinephrine-dopamine reuptake inhibitor, increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters.

HY-A0007

Rotigotine Hydrochloride N-0923 Hydrochloride	Dopamine Receptor Adrenergic Receptor 5-HT Receptor	Neurological Disease
Rotigotine Hydrochloride (N-0923 Hydrochloride) is a full agonist of **dopamine receptor*, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with K_i* of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-14328

Sonepiprazole PNU-101387G; U-101387G	Dopamine Receptor	Neurological Disease
Sonepiprazole (PNU-101387G) is a selective D4 dopamine antagonist with K_is of 3.6, 10.1, 5147, and 7430 nM for rD4-Dopamine, hD4.2-Dopamine, rD2-Dopamine, and Histamine-H1 receptors, respectively.

HY-15394

(Rac)-Rotigotine hydrochloride	Dopamine Receptor Adrenergic Receptor 5-HT Receptor	Endocrinology Neurological Disease
(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine *receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with K_is of 0.71 nM, 4-15 nM, and 83 nM for the dopamine* D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-100143

Pentiapine
CGS 10746
Dopamine Receptor Neurological Disease

Pentiapine (CGS 10746) is a dopamine release inhibitor without binding to synaptic dopamine receptor sites.
HY-U00227

U91356
Dopamine Receptor Neurological Disease

U91356 is a dopamine receptor agonist.

HY-B1110S

Nomifensine-d3 maleate	Dopamine Receptor	Neurological Disease
Nomifensine-d₃ (maleate) is the deuterium labeled Nomifensine maleate. Nomifensine is a norepinephrine-dopamine reuptake inhibitor, increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters.

HY-15394S

(Rac)-Rotigotine-d7 hydrochloride	Dopamine Receptor Adrenergic Receptor 5-HT Receptor	Endocrinology Neurological Disease
(Rac)-Rotigotine-d₇ (hydrochloride) is deuterium labeled (Rac)-Rotigotine (hydrochloride). (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-11018

Risperidone R 64 766	5-HT Receptor Dopamine Receptor P-glycoprotein	Neurological Disease
Risperidone is a serotonin 5-HT₂ receptor blocker, P-Glycoprotein inhibitor and potent **dopamine D₂ receptor antagonist, with K_is** of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively.

HY-106584

Mosapramine Clospipramine	Dopamine Receptor	Neurological Disease
Mosapramine (Clospipramine) is an orally active and potent **dopamine receptor** antagonist with high affinity to dopamine receptor subtypes 2, 3 and 4, and with moderate affinity for the 5-HT² receptor. Mosapramine shows antipsychotic activity and can be used in schizophrenia research.

HY-101641

NRA-0160	Dopamine Receptor 5-HT Receptor Adrenergic Receptor	Neurological Disease Endocrinology
NRA-0160 is a selective **dopamine D4 receptor antagonist, with a K_i value of 0.48 nM and with negligible affinity for dopamine D2 receptor (K_i*: >10000 nM), D3 receptor* (K_i: 39 nM), rat 5-HT2A receptor (K_i: 180 nM) and rat α1 adrenoceptor (K_i: 237 nM).

HY-15238

ST-836
Dopamine Receptor Neurological Disease

ST-836 is a dopamine receptor ligand; Antiparkinsonian agent.

HY-114085

BP 897	Dopamine Receptor	Neurological Disease
BP 897 is a potent and partial **dopamine D3 receptor** agonist and a weak D2 receptor antagonist. BP 897 displays a high affinity at the **dopamine D3 receptor (K_i*=0.92 nM) and a 70 times lower affinity at the D2 receptor* (K_i=61 nM).

HY-106660

BP 897 hydrochloride	Dopamine Receptor	Neurological Disease
BP 897 hydrochloride is a potent and partial **dopamine D3 receptor** agonist and a weak D2 receptor antagonist. BP 897 hydrochloride displays a high affinity at the **dopamine D3 receptor (K_i*=0.92 nM) and a 70 times lower affinity at the D2 receptor* (K_i=61 nM).

HY-11018A

Risperidone hydrochloride R 64 766 hydrochloride	5-HT Receptor Dopamine Receptor P-glycoprotein	Neurological Disease
Risperidone hydrochloride (R 64 766 hydrochloride) 5-HT₂ receptor blocker, P-Glycoprotein inhibitor and potent **dopamine D₂ receptor antagonist, with K_is** of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively.

HY-103416

A-77636 hydrochloride	Dopamine Receptor	Neurological Disease
A-77636 hydrochloride is a potent, orally active, selective and long acting **dopamine D1 receptor agonist (pK_i=7.40; K_i*=39.8 nM) with antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine* D2 receptor.

HY-109167

Aramisulpride R-(+)-Amisulpride	Dopamine Receptor	Neurological Disease
Aramisulpride is a **dopamine D2 receptor** and serotonin receptor antagonist used for the research of metabolic disorders.

HY-101583

NEO 376 SPI-376	5-HT Receptor GABA Receptor Dopamine Receptor	Neurological Disease
NEO 376 is a selective modulator of 5-HT1 receptor, GABA receptor and **dopamine receptor**, with anti-psychotic actively.

HY-111066A

JNJ-37822681 dihydrochloride	Dopamine Receptor	Neurological Disease
JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D₂ receptor antagonist with a moderate binding affinity for the dopamine D_2L receptor (K_i =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder.

HY-11018B

Risperidone mesylate R 64 766 mesylate	5-HT Receptor Dopamine Receptor P-glycoprotein	Neurological Disease
Risperidone mesylate(R 64 766 mesylate) is a serotonin 5-HT₂ receptor blocker, P-Glycoprotein inhibitor and potent **dopamine D₂ receptor antagonist, with K_is** of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively.

HY-103104

Fananserin RP 62203	5-HT Receptor Dopamine Receptor	Neurological Disease
Fananserin (RP 62203) is an orally bioavailable, potent and selective 5-hydroxytryptamine2 (5-HT₂) receptor antagonist, with a K_i of 0.37 nM for the rat 5-HT_2A receptor. Fananserin also is a selective dopamine D4 receptor antagonist, with a K_i of 2.93 nM for the human dopamine D4 receptor.

HY-14545A

Amisulpride hydrochloride DAN 2163 hydrochloride	Dopamine Receptor	Neurological Disease
Amisulpride hydrochloride is a dopamine D₂/D₃ receptor antagonist with K_is of 2.8 and 3.2 nM for human dopamine D₂ and D₃, respectively.

HY-14545

Amisulpride DAN 2163	Dopamine Receptor	Cancer Neurological Disease
Amisulpride is a **dopamine D₂/D₃ receptor antagonist with K_i*s of 2.8 and 3.2 nM for human dopamine* D₂ and D₃, respectively.

HY-14538

Haloperidol
Dopamine Receptor Neurological Disease

Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic.
HY-14538A

Haloperidol hydrochloride
Dopamine Receptor Neurological Disease

Haloperidol hydrochloride is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic.
HY-21098A

PD-168077 maleate
Dopamine Receptor Neurological Disease

PD-168077 maleate is a selective dopamine D₄ receptor agonist, with a K_i of 9 nM.

HY-110232

Risperidone-d4 R 64 766-d₄	5-HT Receptor Dopamine Receptor P-glycoprotein	Neurological Disease
Risperidone-d₄ is the deuterium labeled Risperidone. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.

HY-103409

ABT-724 trihydrochloride	Dopamine Receptor	Neurological Disease
ABT-724 trihydrochloride is a potent and highly selective **dopamine D₄ receptor agonist with an EC₅₀** of 12.4 nM for human dopamine D₄ receptor. ABT-724 trihydrochloride is a potent partial agonist at the rat D₄ (EC₅₀ of 14.3 nM) and the ferret D₄ receptor (EC₅₀ of 23.2 nM), and has no effect on dopamine D₁, D₂, D₃, or D₅ receptors. ABT-724 trihydrochloride could be useful for the treatment of erectile dysfunction and has favorable side-effect profile.

HY-U00400

PF-592379
Dopamine Receptor Neurological Disease

PF-592379 is a potent dopamine D₃ receptor agonist with an EC₅₀ of 21 nM.

HY-135194

Risperidone E-oxime	Drug Metabolite	Others
Risperidone E-oxime is an impurity of Risperidone. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with K_is of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively .

HY-14330

ABT-724	Dopamine Receptor	Neurological Disease
ABT-724 is a potent and highly selective **dopamine D₄ receptor agonist with an EC₅₀** of 12.4 nM for human dopamine D₄ receptor. ABT-724 is a potent partial agonist at the rat D₄ (EC₅₀ of 14.3 nM) and the ferret D₄ receptor (EC₅₀ of 23.2 nM). ABT-724 has no effect on dopamine D₁, D₂, D₃, or D₅ receptors. ABT-724 could be useful for the treatment of erectile dysfunction and has favorable side-effect profile.

HY-101299

(+)-Dihydrexidine hydrochloride (+)-DAR-0100 hydrochloride	Dopamine Receptor	Neurological Disease
(+)-Dihydrexidine hydrochloride ((+)-DAR-0100 hydrochloride) is a **dopamine D1 receptor agonist with an EC₅₀** of 72± 21 nM.

HY-101384A

Ro 10-5824 dihydrochloride
Dopamine Receptor Others

Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist, with K_i of 5.2 nM.
HY-12236

SKF 81297 hydrobromide
Dopamine Receptor Neurological Disease

SKF 81297 hydrobromide is a potent and selective dopamine D1 receptor agonist.

HY-12987

Pimozide R6238	Dopamine Receptor Adrenergic Receptor STAT Parasite	Cancer Neurological Disease Endocrinology
Pimozide is a **dopamine receptor antagonist, with K_i*s of 1.4 nM, 2.5 nM and 588 nM for dopamine* D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a K_i of 39 nM; Pimozide also inhibits STAT3 and STAT5.

HY-103423

PAOPA	Dopamine Receptor	Neurological Disease
PAOPA, an analog of L-proline-l-leucine-glycine amide (PLG) peptide, is an allosteric modulator of **Dopamine D2 Receptor*. PAOPA can effectively reduce behavioral abnormalities in rodent models of schizophrenia. PAOPA increases the high affinity dopamine* D2 receptor and promotes its binding to agonists.

HY-116941

A-381393	Dopamine Receptor	Neurological Disease
A-381393 is a potent, selective, brain penetrate **dopamine D₄ receptor antagonist, with K_i*s of 1.5, 1.9 and 1.6 nM for human dopamine* D_4.4, D_4.2, and D_4.7 receptor, respectively, >2700-fold selectivity over D₁, D₂, D₃ and D₅ dopamine receptors. A-381393 shows moderate affinity for 5-HT_2A (K_i, 370 nM).

HY-P0079

Neuromedin N Neuromedin N (rat, mouse, porcine, canine)	Dopamine Receptor	Neurological Disease
Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.

HY-120687

A68930
Dopamine Receptor Cancer

A68930, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis.
HY-103431

A68930 hydrochloride
Dopamine Receptor Others

A68930 hydrochloride, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis.
HY-19654

GSK598809
Dopamine Receptor Neurological Disease

GSK598809 is a potent and selective dopamine D3 Receptor (DRD3) antagonist, with a pK_i of 8.9.

HY-10684

Pridopidine ACR16; ASP2314; FR310826	Dopamine Receptor	Neurological Disease
Pridopidine, a *dopamine* (DA) stabilizer, acts as a low affinity **dopamine D2 receptor (D2R*) antagonist. Pridopidine exerts high affinity towards sigma 1 receptor* (S1R) with K_i between 70 and 80 nM, which is ~100× higher than its affinity toward D2R.

HY-119943A

(Rac)-PF-06256142	Dopamine Receptor	Neurological Disease
(Rac)-PF-06256142 is the less effective enantiomer of PF-06256142 (HY-119943). (Rac)-PF-06256142 is an agonist of D1 receptor, with an EC₅₀ of 107 nM. (Rac)-PF-06256142 can be used for the research of schizophrenia and Parkinson's disease.

HY-119943

PF-06256142	Dopamine Receptor	Neurological Disease
PF-06256142 is a potent, selective, CNS-penetrant and orally active agonist of the D1 receptor, with an EC₅₀ and K_i of 33 nM and 12 nM, respectively. PF-06256142 has the potential for the research of schizophrenia and Parkinson's disease.

HY-141495

(Rac)-Razpipadon PW0464	Dopamine Receptor	Neurological Disease
PW0464, a nanomolar potent complete G protein biased ligand, is a noncatechol D1R agonist, with an EC₅₀ of 5.8 nM (Gs-cAMP).

HY-B0411

Domperidone R33812	Dopamine Receptor	Neurological Disease
Domperidone (R33812) is an orally active and selective **dopamine-2 receptor** antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine.

HY-101619

Abaperidone
Dopamine Receptor 5-HT Receptor Neurological Disease

Abaperidone is a potent antagonist of 5-HT_2A receptor and dopamine D₂ receptor with IC₅₀s of 6.2 and 17 nM.
HY-14538S

Haloperidol D4
Dopamine Receptor Neurological Disease

Haloperidol-d₄ is deuterium labeled haloperidol, and the latter is a potent dopamine D2 receptor antagonist.
HY-103408

PG01037 dihydrochloride
Dopamine Receptor Neurological Disease

PG01037 (dihydrochloride) is a potent and selective dopamine D3 receptor antagonist with a K_i of 0.7 nM.

HY-109131

Foscarbidopa Carbidopa 4′-monophosphate	Dopamine Receptor	Neurological Disease
Foscarbidopa (Carbidopa 4′-monophosphate) is a proagent of Carbidopa, acts as a **dopamine receptor** agonist.

HY-16567

Asenapine hydrochloride	5-HT Receptor Dopamine Receptor	Neurological Disease
Asenapine hydrochloride, an antipsychotic, is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and Dopamine (D₂, D₃, D₄) receptor antagonist with K_i values of 0.03-4.0 nM for 5-HT and 1.3, 0.42, 1.1 nM for Dopamine receptor, respectively.

HY-B0031S

Quetiapine-d4 fumarate	5-HT Receptor Dopamine Receptor	Neurological Disease
Quetiapine-d₄ (fumarate) is the deuterium labeled Quetiapine fumarate. Quetiapine fumarate is a 5-HT receptors agonist and a dopamine receptor antagonist. Antidepressant and anxiolytic effects[1].

HY-B0411A

Domperidone monomaleate R33812 monomaleate	Dopamine Receptor	Neurological Disease
Domperidone (R33812) monomaleate is an orally active and selective **dopamine-2 receptor** antagonist. Domperidone monomaleate acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine.

HY-10435

SKF-82958 (±)-SKF-82958; Chloro-APB	Dopamine Receptor	Neurological Disease
SKF-82958 ((±)-SKF 82958) is a **dopamine D1 receptor** full agonist (K_0.5=4 nM), displays selective for D1 over D2 receptors (K_0.5=73 nM). SKF-82958 induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC₅₀=491 nM).

HY-103428

LE 300	Dopamine Receptor 5-HT Receptor	Neurological Disease
LE 300 is a potent and selective **dopamine D1-like receptor antagonist with K_i*s of 1.9 nM and 7.5 nM in CHO cell membranes expressing human dopamine* D1 and D5 receptors, respectively. LE 300 is an antagonist of the 5-HT_2A receptor with a pA2 of 8.32 in a rat tail artery assay.

HY-119980

Fluphenazine	Dopamine Receptor Sodium Channel SARS-CoV	Infection Neurological Disease
Fluphenazine is a potent, orally active phenothiazine-based **dopamine receptor antagonist. Fluphenazine blocks neuronal voltage-gated sodium channels*. Fluphenazine acts primarily through antagonism of postsynaptic dopamine-2 receptors* in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2.

HY-106094

CY 208-243
Dopamine Receptor Neurological Disease

CY 208-243 is a selective dopamine D1 receptor agonist which exhibits antiparkinsonian activity.
HY-B1752A

Quinpirole Hydrochloride
(-)-LY 171555
Dopamine Receptor Neurological Disease

Quinpirole Hydrochloride ((-)-LY 171555) is a high-affinity agonist of dopamine D2/D3 receptor.
HY-14538S1

Haloperidol (D4')
Dopamine Receptor Neurological Disease

Haloperidol-d₄-1 is deuterium labeled haloperidol, and the latter is a potent dopamine D2 receptor antagonist.

HY-10435A

SKF-82958 hydrobromide (±)-SKF-82958 hydrobromide; Chloro-APB hydrobromide	Dopamine Receptor	Neurological Disease
SKF-82958 ((±)-SKF 82958) hydrobromide is a **dopamine D1 receptor** full agonist (K_0.5=4 nM), displays selective for D1 over D2 receptors (K_0.5=73 nM). SKF-82958 hydrobromide induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC₅₀=491 nM).

HY-12520A

SKF 38393 hydrochloride (±)-SKF-38393 hydrochloride; SKF-38393A	Dopamine Receptor	Neurological Disease
SKF 38393 hydrochloride is a selective agonist of the dopamine D1 receptor (D1DR) with an IC₅₀ of 110 nM.

HY-A0125A

Alizapride hydrochloride	Dopamine Receptor	Cancer Neurological Disease
Alizapride is a potent antiemetic, acting as a **dopamine receptor** antagonist. Alizapride also used in human digestive disorders.

HY-19654C

(-)-GSK598809 hydrochloride (1S,5R)-GSK598809 hydrochloride	Dopamine Receptor	Neurological Disease
(-)-GSK598809 is an isomer of GSK598809. GSK598809 is a potent and selective dopamine D3 Receptor (DRD3) antagonist.

HY-19489S

(±)-Levomepromazine-d6 (±)-Methotrimeprazine-d₆; dl-Methotrimeprazine-d₆	Dopamine Receptor Histamine Receptor	Neurological Disease
(±)-Levomepromazine-d₆ is the deuterium labeled Methotrimeprazine, which is a D3 dopamine and Histamine H1 receptor antagonist.

HY-A0163

Zuclopenthixol
(Z)-Clopenthixol
Dopamine Receptor Neurological Disease

Zuclopenthixol is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist.

HY-103638

3-Methoxytyramine hydrochloride 3-O-methyl Dopamine hydrochloride	Drug Metabolite Endogenous Metabolite	Neurological Disease
3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate *trace amine* associated receptor 1 (TAAR1**).

HY-14545S

Amisulpride-d5	Dopamine Receptor	Cancer Neurological Disease
Amisulpride-d₅ is the deuterium labeled Amisulpride. Amisulpride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively[1][2].

HY-P1083

Dynamin inhibitory peptide	Dynamin	Neurological Disease
Dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide blocks the dopamine D3 effect on GABAA receptors.

HY-B0031S1

Quetiapine-d4 hemifumarate	5-HT Receptor Dopamine Receptor	Neurological Disease
Quetiapine-d₄ (hemifumarate) is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a 5-HT receptors agonist and a dopamine receptor antagonist. Antidepressant and anxiolytic effects[1].

HY-103410

Carmoxirole hydrochloride EMD 45609 hydrochloride	Dopamine Receptor	Cardiovascular Disease
Carmoxirole hydrochloride (EMD 45609 hydrochloride) is a selective, peripherally acting **dopamine D2 receptor** agonist and exhibits antihypertensive activities in vivo.

HY-121685

Tipepidine	Potassium Channel	Neurological Disease
Tipepidine reversibly inhibits dopamine (DA) D₂ receptor-mediated GIRK currents (I_DA(GIRK)) with an IC₅₀ of 7.0 μM. Tipepidine subsequently activates VTA dopamine neuron. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect.

HY-14545S1

Amisulpride-d5 N-Oxide	Dopamine Receptor	Cancer Neurological Disease
Amisulpride-d₅ N-Oxide is the deuterium labeled Amisulpride. Amisulpride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively[1][2].

HY-B0411S

Domperidone-d6	Dopamine Receptor	Neurological Disease
Domperidone-d₆ is the deuterium labeled Domperidone. Domperidone (R33812) is a selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1][2].

HY-121685A

Tipepidine hydrochloride	Potassium Channel	Neurological Disease
Tipepidine hydrochloride reversibly inhibits dopamine (DA) D₂ receptor-mediated GIRK currents (I_DA(GIRK)) with an IC₅₀ of 7.0 μM. Tipepidine hydrochloride subsequently activates VTA dopamine neuron. Tipepidine hydrochloride, a non-narcotic antitussive, exerts an antidepressant-like effect.

HY-12987S1

Pimozide-d5 N-Oxide	Dopamine Receptor Adrenergic Receptor STAT	Cancer Neurological Disease Endocrinology
Pimozide-d₅ N-Oxide is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5[1][2].

HY-12987S

Pimozide-d4 R6238-d₄	Dopamine Receptor Adrenergic Receptor STAT	Cancer Endocrinology Neurological Disease
Pimozide-d₄ is a deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5[1][2][3].

HY-W152604

Cyclo(glycyl-L-leucyl) Cyclo(leu-gly)	Dopamine Receptor	Neurological Disease
Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates **dopamine (DA) receptors** and attenuates dopaminergic supersensitivity. Cyclo(glycyl-L-leucyl) inhibits the development of Morphine induced pain relief as well as dopamine receptor supersensitivity in rats. Cyclo(glycyl-L-leucyl) has the potential for the prevention of tardive and/or L-DOPA (HY-N0304)-induced dyskinesias.

HY-G0014

Quetiapine sulfoxide Quetiapine S-oxide	Drug Metabolite	Neurological Disease
Quetiapine sulfoxide (Quetiapine S-oxide) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist.

HY-101313

(S)-Remoxipride (-)-Remoxipride	Dopamine Receptor	Neurological Disease
(S)-Remoxipride ((-)-Remoxipride) is a selective dopamine *D₂-receptor* antagonist with an IC₅₀ value of 1.57 μM. (S)-Remoxipride can be used for the research of psychotic disorder.

HY-G0014B

Quetiapine sulfoxide hydrochloride Quetiapine S-oxide hydrochloride	Drug Metabolite	Neurological Disease
Quetiapine sulfoxide hydrochloride (Quetiapine S-oxide hydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist.

HY-G0014A

Quetiapine sulfoxide dihydrochloride Quetiapine S-oxide dihydrochloride	Drug Metabolite	Neurological Disease
Quetiapine sulfoxide dihydrochloride (Quetiapine S-oxide dihydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist.

HY-P1083A

Dynamin inhibitory peptide TFA	Dynamin	Neurological Disease
Dynamin inhibitory peptide TFA competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide TFA blocks the dopamine D₃ effect on GABA_A receptors.

HY-101382

GR 103691	Dopamine Receptor	Neurological Disease
GR 103691 is a potent, selective **dopamine D₃ receptor antagonist with a K_i** value of 0.4 nM. GR 103691 shows more than 100-fold selectivity for human dopamine human (h)D₃ over hD₄ and hD₁ sites.

HY-119980A

Fluphenazine dimaleate	Dopamine Receptor Sodium Channel SARS-CoV	Infection Neurological Disease
Fluphenazine dimaleate is a potent, orally active phenothiazine-based **dopamine receptor antagonist. Fluphenazine dimaleate blocks neuronal voltage-gated sodium channels*. Fluphenazine dimaleate acts primarily through antagonism of postsynaptic dopamine-2 receptors* in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine dimaleate can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine dimaleate can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2.

HY-A0077AS

Perphenazine-d8 dihydrochloride	Isotope-Labeled Compounds 5-HT Receptor Adrenergic Receptor Dopamine Receptor Histamine Receptor	Endocrinology Neurological Disease
Perphenazine-d₈ (dihydrochloride) is the deuterium labeled Perphenazine, which is a typical antipsychotic agent(5-HT, Dopamine receptor ligand).

HY-A0007S

Rotigotine-d7 hydrochloride N-0923 D7 Hydrochloride	Isotope-Labeled Compounds Dopamine Receptor	Neurological Disease
Rotigotine-d₇ (hydrochloride) is the deuterium labeled Rotigotine(N-0923), which is a dopamine D2 and D3 receptor agonist.

HY-17390

Loxapine	5-HT Receptor Dopamine Receptor Bacterial	Neurological Disease
Loxapine is an orally active *dopamine* inhibitor, 5-HT receptor antagonist and also a dibenzoxazepine anti-psychotic agent.

HY-17390B

Loxapine hydrochloride	Dopamine Receptor 5-HT Receptor	Neurological Disease
Loxapine hydrochloride is an orally active *dopamine* inhibitor, 5-HT receptor antagonist and also a dibenzoxazepine anti-psychotic agent.

HY-14263

Pericyazine Propericiazine; RP 8909	Dopamine Receptor	Neurological Disease
Pericyazine (Propericiazine) is a first-generation antipsychotic agent that is used as an adjunct to the short-term management of severe anxiety states and psychosis. Pericyazine is a selective D2-dopamine receptor antagonist. Pericyazine has adrenolytic, anticholinergic, and extrapyramidal effects.

HY-12987S2

Pimozide-d4-1 R6238-d₄-1	Dopamine Receptor Adrenergic Receptor STAT Parasite	Cancer Endocrinology Neurological Disease
Pimozide-d₄-1 is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5[1][2][3][4].

HY-148867

UCM-1306 2-(Fluoromethoxy)-4'-(S-methylsulfonimidoyl)-1,1'-biphenyl	Dopamine Receptor	Neurological Disease
UCM-1306 is a potent and orally active human **dopamine D1 receptor** allosteric modulator (PAM). UCM-1306 increases the endogenous dopamine (DA) maximal effect both in human and mouse D1 receptors. UCM-1306 is not only for improving motor symptoms but also for addressing the key comorbid cognitive impairment associated with long-term Parkinson’s disease (PD).

HY-103411

SKF83822 hydrobromide	Dopamine Receptor	Neurological Disease
SKF83822 hydrobromide is a potent **dopamine D1 receptor** agonist. SKF83822 hydrobromide activates G_s/_olf/adenylyl cyclase (AC)-coupled D1 receptors, but not phospholipase C (PLC)-coupled D1-like receptors.

HY-100649

Hydroxy ziprasidone	5-HT Receptor Dopamine Receptor	Neurological Disease
Hydroxy ziprasidone is an impurity of Ziprasidone. Ziprasidone, an antipsychotic agent, is a combined 5-HT (serotonin) and dopamine receptor antagonist.

HY-100648

Keto Ziprasidone	5-HT Receptor Dopamine Receptor	Neurological Disease
Keto Ziprasidone is an impurity of Ziprasidone. Ziprasidone, an antipsychotic agent, is a combined 5-HT (serotonin) and dopamine receptor antagonist.

HY-14538S3

Haloperidol-13C6	Isotope-Labeled Compounds Dopamine Receptor	Neurological Disease
Haloperidol-¹³C₆ is the ¹³C₆ labeled Haloperidol. Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic.

HY-125043

SKF-75670 hydrobromide
Dopamine Receptor Neurological Disease

SKF-75670 hydrochloride is a Dopamine D1 receptor partial agonist. SKF-75670 hydrochloride is also a Cocaine antagonist.

HY-107031

Metapramine 19560 RP	iGluR	Others
Metapramine (19560 RP) is an antidepressant agent, belonging to the class of tricyclic compounds. Metapramine inhibits norepinephrine reuptake, without affecting the reuptake of serotonin or dopamine. Metapramine is a low-affinity antagonist of the N-methyl-D-aspartic acid (NMDA) receptor complex channel.

HY-120879

PF2562	Dopamine Receptor	Neurological Disease
PF2562 (Example 6), a dopamine D1 ligand, ascts as a dopamine D1 agonist or partial agonist. PF2562 binds to human D1 receptor with a K_i of 113 nM. PF2562 exhibits activity against human D1 cAMP with an EC₅₀ of 568 nM in HTRF assay.

HY-B0732S

Itopride-d6 hydrochloride HSR803-d₆ hydrochloride	Isotope-Labeled Compounds Cholinesterase (ChE) Dopamine Receptor	Neurological Disease
Itopride-d₆ (hydrochloride) is deuterium labeled Itopride (hydrochloride). Itopride hydrochloride (HSR803), a gastroprokinetic Benzamide (HY-Z0283) derivative, is an inhibitor of acetylcholinesterase (AChE) and dopamine D2 receptor[1][2].

HY-108510

Rimcazole dihydrochloride BW 234U dihydrochloride	Sigma Receptor Dopamine Receptor	Cancer Neurological Disease
Rimcazole (BW 234U) dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the dopamine transporter and inhibit dopamine uptake. Rimcazole dihydrochloride can reduce locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer.

HY-13720

Pergolide LY127809 free base	Dopamine Receptor	Neurological Disease
Pergolide (LY127809 (free base)) is an ergot-derived orally active **dopamine receptor** agonist. Pergolide can be used for Parkinson disease research.

HY-B1904

Fluphenazine decanoate	Dopamine Receptor	Neurological Disease
Fluphenazine decanoate is a **dopamine D₂ receptor inhibitor, is a long-acting phenothiazine neuroleptic**. Fluphenazine can be used for schizophrenia research.

HY-B1904A

Fluphenazine decanoate dihydrochloride	Dopamine Receptor	Neurological Disease
Fluphenazine decanoate dihydrochloride is a **dopamine D₂ receptor inhibitor, is a long-acting phenothiazine neuroleptic**. Fluphenazine can be used for schizophrenia research.

HY-A0008

Talipexole dihydrochloride B-HT 920 dihydrochloride	Adrenergic Receptor Dopamine Receptor 5-HT Receptor	Neurological Disease Endocrinology
Talipexole dihydrochloride (B-HT 920 dihydrochloride) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays antiParkinsonian activity.

HY-110000

(+)-PD 128907 hydrochloride	Dopamine Receptor	Neurological Disease
(+)-PD 128907 hydrochloride is a selective dopamine D₂/D₃ receptor agonist, with K_is of 1.7, 0.84 nM for human and rat D₃ receptors, 179, 770 n M for human and rat D₃ receptors, respectively.

HY-90003A

Tianeptine sodium salt	5-HT Receptor	Neurological Disease
Tianeptine sodium salt is a selective facilitator of 5-HT uptake. Tianeptine sodium salt has no affinity for a wide range of receptors, including 5-HT and dopamine (IC₅₀>10 μM) and has no effect on noradrenalin or dopamine uptake. Tianeptine sodium salt has antidepressant, anxiolytic, analgesic and neuroprotective activities.

HY-90003

Tianeptine	5-HT Receptor	Neurological Disease
Tianeptine is a selective facilitator of 5-HT uptake. Tianeptine has no affinity for a wide range of receptors, including 5-HT and dopamine (IC₅₀>10 μM) and has no effect on noradrenalin or dopamine uptake. Tianeptine has antidepressant, anxiolytic, analgesic and neuroprotective activities.

HY-16567S

Asenapine-13C,d3 hydrochloride	Isotope-Labeled Compounds 5-HT Receptor Dopamine Receptor	Neurological Disease
Asenapine-¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled Asenapine (hydrochloride). Asenapine hydrochloride, an antipsychotic, is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and Dopamine (D2, D3, D4) receptor antagonist with Ki values of 0.03-4.0 nM for 5-HT and 1.3, 0.42, 1.1 nM for Dopamine receptor, respectively.

HY-B0520A

Benztropine mesylate Benzatropine mesylate; Benzotropine mesylate; Benztropine methanesulfonate	Dopamine Receptor mAChR Histamine Receptor	Cancer Neurological Disease
Benztropine mesylate (Benzatropine mesylate) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D₂ dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects.

HY-N2003

D-Tetrahydropalmatine	Dopamine Receptor	Metabolic Disease
D-Tetrahydropalmatine is an isoquinoline alkaloid, mainly in the genus Corydalis. D-Tetrahydropalmatine is a dopamine (DA) receptor antagonist with preferential affinity toward the D1 receptors. D-Tetrahydropalmatine is a potent organic cation transporter 1 (OCT1) inhibitor.

HY-B0274

Chlorprothixene	Dopamine Receptor Histamine Receptor Bacterial	Neurological Disease
Chlorprothixene is a *dopamine* and histamine receptors antagonist with K_is of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity.

HY-B0274A

Chlorprothixene hydrochloride	Dopamine Receptor Histamine Receptor Bacterial	Neurological Disease
Chlorprothixene hydrochloride is a *dopamine* and histamine receptors antagonist with K_is of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity.

HY-103414

Raclopride	Dopamine Receptor	Neurological Disease
Raclopride is a dopamine D₂/D₃ receptor antagonist with potential antipsychotic effects. Raclopride binds to D₂ and D₃ receptors with K_is of 1.8 nM and 3.5 nM, respectively.

HY-P3294

Onzigolide BIM-23A760; TBR-760	Dopamine Receptor Somatostatin Receptor	Neurological Disease Cancer
Onzigolide (BIM-23A760), a chimeric dopamine-somatostatin compound, shows potent agonist activity at both DA type 2 (D2R) and SST type 2 (SSTR2) receptors.

HY-14538S2

Haloperidol-d4 N-Oxide	Dopamine Receptor	Neurological Disease
Haloperidol-d₄ N-Oxide is the deuterium labeled Haloperidol. Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic[1][2].

HY-109162

Trazpiroben
TAK-906
Dopamine Receptor Neurological Disease

Trazpiroben (TAK-906) is a dopamine D2/D3 receptor antagonist used for chronic research of moderate-to-severe gastroparesis.

HY-14542S

Ziprasidone-d8 CP-88059 d₈	Isotope-Labeled Compounds 5-HT Receptor Dopamine Receptor	Neurological Disease
Ziprasidone-d₈8 is deuterium labeled Ziprasidone, which is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity.

HY-145454

(R)-Preclamol (+)-3-PPP	Dopamine Receptor	Neurological Disease
(R)-Preclamol is a dopamine (DA) agonist with autoreceptor as well as postsynaptic receptor stimulatory properties. (R)-Preclamol inhibits the locomotor activity of mice and rats in low doses.

HY-13221

BRL 54443	5-HT Receptor	Cardiovascular Disease
BRL 54443 is a potent 5-HT_1E/1F receptor agonist (K_i values are 1.1 nM and 0.7 nM respectively); displays > 30-fold selectivity over other 5-HT and dopamine receptors.

HY-102089

Fluoroclebopride	Dopamine Receptor	Neurological Disease
Fluoroclebopride binds reversibly to **dopamine receptors*. ¹⁸F labeled fluoroclebopride has been used as a probe for studying D2/D3 receptor* availability via PET in various monkey models.

HY-B0520

Benztropine Benzatropine; Benzotropine	Dopamine Receptor mAChR Histamine Receptor
Benztropine (Benzatropine; Benzotropine) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine is also a human D₂ dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects.

HY-W040146S

Propionylpromazine-d6 hydrochloride	Dopamine Receptor	Neurological Disease
Propionylpromazine-d₆ (hydrochloride) is the deuterium labeled Propionylpromazine hydrochloride. Propionylpromazine hydrochloride (Propiopromazine hydrochloride), a dopamine receptor D2 (DRD2) antagonist, can be used in the research of Parkinson disease[1].

HY-12713

Lisuride	Dopamine Receptor	Neurological Disease
Lisuride is an orally active **dopamine D2 receptors** agonist. Lisuride, as an ergot derivative, can be used for the research of Parkinson's disease, migraine, and high prolactin levels.

HY-123837

MLS1082	Dopamine Receptor	Neurological Disease
MLS1082 is a pyrimidone-based D1-like dopamine receptor positive allosteric modulator, with an EC₅₀ of 123 nM for DA-stimulated G protein signaling.

HY-131255

Ziprasidone amino acid Ziprasidone Impurity C; Ziprasidone open ring impurity	5-HT Receptor Dopamine Receptor	Neurological Disease
Ziprasidone amino acid (Ziprasidone Impurity C) is an impurity of Ziprasidone. Ziprasidone is a combined 5-HT (serotonin) and **dopamine receptor** antagonist. Ziprasidone exhibits potent effects of antipsychotic activity .

HY-107707

TCS 46b
iGluR Neurological Disease

TCS 46b (Compound 46b) is a potent, selective and orally active NMDA NR1A/2B receptor antagonist with an IC₅₀ of 5.3 nM.

HY-110160

Pozanicline dihydrochloride ABT-089 dihydrochloride	nAChR	Neurological Disease
Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a K_i of 16.7 nM for binding to [³H]cytisine sites. Pozanicline is an α4β2-selective nAChR agonist, which binds to rat brain α4β2 nAChR with a K_i of 17 nM while binding to α7 nAChR is insignificant.

HY-119943B

(R)-PF-06256142	Others	Neurological Disease
(R)-PF-06256142 is the R enantiomer of PF-06256142 with low active. PF-06256142 is a potent and selective orthosteric D1 receptor agonist that can reduce receptor desensitization relative to dopamine and other catechol-containing agonists.

HY-B1794

Thiethylperazine	Dopamine Receptor Histamine Receptor Bacterial Amyloid-β	Infection Neurological Disease
Thiethylperazine, a phenothiazine derivate, is an orally active and potent **dopamine D2-receptor** and histamine H1-receptor antagonist. Thiethylperazine is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine has anti-emetic, antipsychotic and antimicrobial effects.

HY-110024

S-14506 hydrochloride	5-HT Receptor	Neurological Disease Others
S-14506 hydrochloride is a potent 5-HT1A agonist. S-14506 hydrochloride displays dopamine antagonist properties by blocking dopamine D2 receptors. S-14506 hydrochloride inhibits the in vivo binding of [3H]raclopride in striatum and olfactory bulbs. S-14506 hydrochloride has the potential for the research of anxiolytic agent.

HY-13575S1

Blonanserin-d5 AD-5423-d₅	5-HT Receptor Dopamine Receptor	Neurological Disease
Blonanserin-d₅ is a deuterium labeled Blonanserin. Blonanserin is a dopamine D2/5-HT2 receptor antagonist and an atypical antipsychotic[1][2].

HY-107434

Molindone (±)-Molindone; SPN-810M	Dopamine Receptor	Neurological Disease
Molindone ((±)-Molindone), an indole derivative, is a potent dopamine D2 and D5 receptor antagonist. Molindone ((±)-Molindone) can be used for the research of schizophrenia and severe mental illness.

HY-13575S

Blonanserin D8 AD-5423 d₈	5-HT Receptor Dopamine Receptor	Neurological Disease
Blonanserin-d₈ is a deuterium labeled Blonanserin. Blonanserin is a dopamine D2/5-HT2 receptor antagonist and an atypical antipsychotic[1][2].

HY-103429

Quinelorane dihydrochloride LY163502	Dopamine Receptor	Neurological Disease
Quinelorane dihydrochloride (LY163502) is a potent **dopamine D3/D2 receptor** agonist. Quinelorane has the potential for neurological and psychiatric disorders research.

HY-B0901A

Bromperidol hydrochloride R-11333 hydrochloride	Dopamine Receptor Bacterial	Neurological Disease
Bromperidol (R-11333) hydrochloride possesses antipsychotic activity, with a high affinity for central dopamine receptors D₂. Bromperidol hydrochloride can kill Mycobacteria in a synergistic manner with Spectinomycin.

HY-B0901

Bromperidol R-11333	Dopamine Receptor Bacterial	Infection Neurological Disease
Bromperidol (R-11333) possesses antipsychotic activity, with a high affinity for central dopamine receptors D₂. Bromperidol can kill Mycobacteria in a synergistic manner with Spectinomycin.

HY-14958A

Pardoprunox hydrochloride SLV-308 hydrochloride; DU-126891 hydrochloride	5-HT Receptor Adrenergic Receptor Dopamine Receptor	Neurological Disease Endocrinology
Pardoprunox (SLV-308) hydrochloride is a partial dopamine D2 and D3 receptor partial agonist and a serotonin 5-HT1A receptor agonist, with pEC₅₀s of 8, 9.2, and 6.3, respectively.

HY-108976

Raclopride tartrate	Dopamine Receptor	Neurological Disease
Raclopride tartrate is a selective dopamine D₂/D₃ receptor antagonist with potential antipsychotic effects. Raclopride tartrate binds to D₂ and D₃ receptors with K_is of 1.8 nM and 3.5 nM, respectively.

HY-14958

Pardoprunox SLV-308; DU-126891	5-HT Receptor Adrenergic Receptor Dopamine Receptor	Neurological Disease Endocrinology
Pardoprunox (SLV-308) is a partial dopamine D2 and D3 receptor partial agonist and a serotonin 5-HT1A receptor agonist, with pEC₅₀s of 8, 9.2, and 6.3, respectively.

HY-115447

Clobenpropit	Histamine Receptor	Neurological Disease
Clobenpropit is a potent histamine H3-receptor antagonist. Clobenpropit decreases dopamine release and increases histamine levels in the hypothalamus. Clobenpropit shows antipsychotic-like activities. Clobenpropit causes a resuscitating effect in rats subjected to the hemorrhagic shock.

HY-126068

(S)-Amisulpride Esamisulpride; SEP-4199	Dopamine Receptor 5-HT Receptor	Neurological Disease
(S)-Amisulpride (Esamisulpride) is a potent **dopamine D₂/D₃ receptor** antagonist. (S)-Amisulpride is an antagonist at the 5-HT₇ receptor with a K_I of 900 nM. (S)-Amisulpride has antipsychotic and antidepressant effects.

HY-10121B

Asenapine citrate Org 5222 citrate	5-HT Receptor Dopamine Receptor Adrenergic Receptor Histamine Receptor	Neurological Disease
Asenapine citrate, an atypical antipsychotic, is an antagonist of serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i: 8.9-9.5), **dopamine receptors (pK_i*: 8.9-9.4) and histamine receptors* (pK_i: 8.2-9.0). Asenapine citrate can be used in the research of schizophrenia and bipolar disorder.

HY-B1794A

Thiethylperazine dimaleate	Dopamine Receptor Histamine Receptor Bacterial Amyloid-β	Infection Neurological Disease
Thiethylperazine dimaleate, a phenothiazine derivate, is an orally active and potent **dopamine D2-receptor** and histamine H1-receptor antagonist. Thiethylperazine dimaleate is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine dimaleate has anti-emetic, antipsychotic and antimicrobial effects.

HY-10791

Ritanserin R 55667	5-HT Receptor Histamine Receptor Dopamine Receptor Adrenergic Receptor	Neurological Disease
Ritanserin (R 55667) is a highly potent, relatively selective, orally active, long acting antagonist of 5-HT₂ receptor, with an IC₅₀ of 0.9 nM, less active on Histamine H₁, Dopamine D₂, Adrenergic α₁, Adrenergic α₂ receptors.

HY-13720A

Pergolide mesylate Pergolide methanesulfonate; LY127809	Dopamine Receptor	Neurological Disease
Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D₁ and D₂ receptors agonist. Pergolide mesylate can be used for Parkinson's disease and hyperprolactinaemia research.

HY-129059

Odapipam NNC 756	Dopamine Receptor	Neurological Disease
Odapipam (NNC 756) is a selective, high affinity and benzazepine **dopamine D₁ receptor antagonist with a K_d** of 0.18 nM. Odapipam is also a superior positron emission tomography (PET) radiotracer.

HY-N2197

Hirsuteine	nAChR	Neurological Disease
Hirsuteine is an indole alkaloid extracted from Uncaria rhynchophylla. Hirsuteine non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes.

HY-19483

ABT-670	Dopamine Receptor	Neurological Disease
ABT-670 is a selective, oral bioavailable agonist of **dopamine D₄ receptor, with EC₅₀** of 89 nM, 160 nM, and 93 nM for human D₄, ferret D₄, and rat D₄, respectively.

HY-116916

Acetophenazine	Dopamine Receptor	Neurological Disease
Acetophenazine, a phenothiazine derivative, is an antipsychotic agent. Acetophenazine primarily blocks **dopamine D2 receptors** in the brain. Acetophenazine can be used for researching psychotic disorders such as schizophrenia and anxious depression.

HY-15296

Cabergoline FCE-21336	Dopamine Receptor Autophagy	Endocrinology Cancer
Cabergoline is an ergot derived-dopamine D₂-like receptor agonist that has high affinity for D₂, D₃, and 5-HT_2B receptors (K_i=0.7, 1.5, and 1.2, respectively).

HY-G0014S

Quetiapine Sulfoxide-d8	Drug Metabolite	Neurological Disease
Quetiapine Sulfoxide-d₈ is the deuterium labeled Quetiapine sulfoxide. Quetiapine sulfoxide (Quetiapine S-oxide) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic[1]. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist[1][2].

HY-19654B

(-)-GSK598809 (1S,5R)-GSK598809	Dopamine Receptor	Others
(-)-GSK598809 ((1S,5R)-GSK598809) is an isomer of GSK598809. GSK598809 is a potent and selective dopamine D3 Receptor (DRD3) antagonist.

HY-13204

Biperiden hydrochloride KL 373 hydrochloride	mAChR	Neurological Disease
Biperiden (KL 373) hydrochloride is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden hydrochloride has the potential for the research of Parkinson's disease and other related psychiatric disorders.

HY-109150

Mesdopetam IRL790	Dopamine Receptor	Neurological Disease
Mesdopetam (IRL790) is a dopamine D3 receptor antagonist (K_i=90 nM; IC₅₀=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam is used for the research of motor and psychiatric complications in Parkinson disease.

HY-13204A

Biperiden KL 373	mAChR	Neurological Disease
Biperiden (KL 373) is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden has the potential for the research of Parkinson's disease and other related psychiatric disorders.

HY-N7512

Asimilobine	Dopamine Receptor 5-HT Receptor Parasite	Cancer Infection
Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a *dopamine* biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity.

HY-19845A

Piperidine-MO-1	Dopamine Receptor	Neurological Disease
Piperidine-MO-1 is a modulator of **dopamine receptor extracted from patent WO/2005/121087A1, compound example 2; exhibits an ED₅₀** of 68 μmol/kg on increase of DOPAC in the rat striatum.

HY-128770

LY3154207	Dopamine Receptor	Neurological Disease
LY3154207 is a potent, subtype selective, and orally available human dopamine D1 receptor positive allosteric modulator (PAM) with minimal allosteric agonist activity (EC₅₀=3 nM).

HY-119093

Halopemide	Phospholipase Dopamine Receptor	Cancer Neurological Disease
Halopemide is a potent phospholipase D (PLD) inhibitor, with IC₅₀s of 220 and 310 nM for human PLD1 and PLD2, respectively. Halopemid is a **dopamine receptors** antagonist, and acts a psychotropic agent.

HY-A0163S

Zuclopenthixol-d4 succinate salt	Dopamine Receptor	Neurological Disease
Zuclopenthixol-d₄ (succinate) is the deuterium labeled Zuclopenthixol. Zuclopenthixol is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist[1][2].

HY-B0274AS

Chlorprothixene-d6 hydrochloride	Dopamine Receptor Histamine Receptor Bacterial	Neurological Disease
Chlorprothixene-d₆ (hydrochloride) is the deuterium labeled Chlorprothixene hydrochloride. Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity[1].

HY-101094

Ocaperidone R79598	5-HT Receptor Dopamine Receptor	Neurological Disease
Ocaperidone is an effective antipsychotic agent, acting as a potent 5-HT₂ and dopamine D₂ antagonist, and a 5-HT_1A agonist, with K_is of 0.14 nM, 0.46 nM, 0.75 nM, 1.6 nM and 5.4 nM for 5-HT₂, a₁-adrenergic receptor, dopamine D₂, histamine H₁ and a₂-adrenergic receptor, respectively, and a pEC₅₀ and pK_i of 7.60 and 8.08 for h5-HT_1A.

HY-B0520AS1

Benztropine-d3 mesylate	Dopamine Receptor Histamine Receptor mAChR
Benztropine-d₃ (mesylate) is the deuterium labeled Benztropine mesylate[1]. Benztropine mesylate (Benzatropine mesylate) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects[2][3].

HY-10847B

SB-277011 hydrochloride SB-277011A hydrochloride	Dopamine Receptor 5-HT Receptor	Neurological Disease
SB-277011 hydrochloride (SB-277011A hydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D₃ receptor (D₃R) antagonist with K_i values of 10.7 nM and 11.2 nM at rodent and human D₃R, respectively. SB-277011 hydrochloride displays 80- to 100-fold selectivity over other dopamine receptors with pK_is of 8.0, 6.0, <5.2, and 5.9 for D3, D2, 5-HT_1B, and 5-HT_1D receptors, respectively.

HY-109112

Brilaroxazine RP5063	Dopamine Receptor 5-HT Receptor	Inflammation/Immunology Neurological Disease
Brilaroxazine (RP5603) is a potent and orally active multimodal dopamine (DA)/serotonin (5-HT) modulator. Brilaroxazine is a partial agonist of dopamine (DA) D2, D3, and D4 receptors, 5-HT1A (K_i=1.5 nM) and 5-HT2A (K_i=2.5 nM), and has antagonist activity at 5-HT2B (K_i=0.19 nM), and 5-HT7 (K_i=2.7 nM) receptors. Brilaroxazine is an atypical antipsychotic agent, and has the potential to improve cognitive impairments in neuropsychiatric and neurological diseases in vivo.

HY-109150A

Mesdopetam hemitartrate IRL790 hemitartrate	Dopamine Receptor	Neurological Disease
Mesdopetam (IRL790) hemitartrate is a dopamine D3 receptor antagonist (K_i=90 nM; IC₅₀=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam hemitartrate is used for the research of motor and psychiatric complications in Parkinson disease.

HY-B1196A

Tiapride	Dopamine Receptor	Neurological Disease
Tiapride, an atypical neuroleptic agent, is a selective **dopamine D2-receptor** antagonist with little propensity for causing catalepsy and sedation. The IC₅₀ values of Tiapride are 1440, 45.8, >100, and 11.7 μM for D1; D2; D3; D4, respectively.

HY-A0125AS

Alizapride-13C,d3 hydrochloride	Dopamine Receptor	Cancer Neurological Disease
Alizapride-¹³C,d₃ (hydrochloride) is deuterium labeled Alizapride (hydrochloride). Alizapride hydrochloride is a dopamine receptor antagonist with prokinetic and antiemetic effects which can also be used in the treatment of nausea and vomiting, including postoperative nausea and vomiting.

HY-15238A

ST-836 hydrochloride	Dopamine Receptor	Neurological Disease
ST-836 hydrochloride (compound 34) is a potent **dopamine receptor ligand with K_i** values of 4.5 nM, 132 nM for D3 and D2, respectively. ST-836 hydrochloride has the potential for Parkinson’s disease.

HY-127086

Dicarbine	Dopamine Receptor	Neurological Disease
Dicarbine blocks **dopamine receptors** in various brain parts and prevents the depression of the conditioned defence reflexes caused by stimulation of the mesencephalic portion of the reticular formation. Dicarbine could be used in the schizophrenia and alcoholic psychosis studies.

HY-B1262

Acetophenazine dimaleate	Dopamine Receptor	Neurological Disease
Acetophenazine dimaleate, a phenothiazine derivative, is an antipsychotic agent. Acetophenazine dimaleate primarily blocks **dopamine D2 receptors** in the brain. Acetophenazine dimaleate can be used for researching psychotic disorders such as schizophrenia and anxious depression.

HY-135525

Agroclavine	Dopamine Receptor Adrenergic Receptor	Cancer Infection
Agroclavine is a natural, clavine type of ergot alkaloid. Agroclavine is a D1 **dopamine receptor and α1-adrenoceptor** agonist. Agroclavine also has anticancer and antimicrobial activities.

HY-103415

Nemonapride YM-09151-2; Emilace; Emonapride	Dopamine Receptor 5-HT Receptor	Neurological Disease
Nemonapride is a highly potent **dopamine D₂ receptor antagonist with a K_i** of 0.06 nM. Nemonapride also activates 5-HT_1A receptor with an IC₅₀ of 34 nM. Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals.

HY-B0520AS

Benztropine-13C,d3 mesylate	Dopamine Receptor mAChR Histamine Receptor	Cancer Neurological Disease
Benztropine-¹³C,d₃ (mesylate) is the ¹³C- and deuterium labeled Benztropine (mesylate). Benztropine mesylate (Benzatropine mesylate) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects[1][2].

HY-14325A

L-745870 trihydrochloride	Dopamine Receptor	Neurological Disease
L-745870 trihydrochloride is a potent, selective, brain-penetrant and orally active **dopamine D₄ receptor antagonist with a K_i of 0.43 nM. L-745870 trihydrochloride shows weaker affinity for D₂ (K_i of 960 nM) and D₃ (K_i** of 2300 nM) receptors, and exhibits moderate affinity for 5-HT₂ receptors, sigma sites and α-adrenoceptors.

HY-B0731

Perospirone hydrochloride SM-9018	5-HT Receptor Dopamine Receptor	Neurological Disease
Perospirone hydrochloride (SM-9018) is an orally active antagonist of 5-HT_2A receptor (K_i of 0.6 nM) and dopamine D₂ receptor (K_i of 1.4 nM). Perospirone hydrochloride is also a partial agonist of 5-HT_1A receptor (K_i of 2.9 nM). Perospirone hydrochloride is an atypical antipsychotic agent and has the potential for schizophrenic disease research.

HY-12324

SB269652	Dopamine Receptor	Neurological Disease
SB269652 is the first drug-like allosteric modulator of the dopamine D2 receptor (D2R); a new chemical probe that can differentiate D2R monomers from dimers or oligomers depending on the observed pharmacology.

HY-103407

PD 168568	Dopamine Receptor	Cancer Neurological Disease
PD 168568 is a orally active and potent dopamine receptor D₄ (DRD₄) antagonist. PD 168568 contains an isoindolinone and is selective for the D₄ receptor versus D₂ and D₃, with K_i values of 8.8, 1842, and 2682 nM, respectively. PD 168568 can be used for glioblastoma (GBM) research.

HY-151450

Cav 3.2 inhibitor 1	Calcium Channel	Inflammation/Immunology Neurological Disease
Cav 3.2 inhibitor 1 is a T-type calcium channel inhibitor with little binding affinity to dopamine D2 receptors. Cav 3.2 inhibitor 1 can be used for the research of somatic and visceral pain.

HY-B0358

Flunarizine	Calcium Channel Sodium Channel Dopamine Receptor	Neurological Disease
Flunarizine is a potent dual Na⁺/Ca²⁺ channel (T-type) blocker. Flunarizine is a D₂ dopamine receptor antagonist. Flunarizine shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects.

HY-103638S

3-Methoxytyramine-d4 hydrochloride 3-O-methyl Dopamine-d₄ (hydrochloride)	Drug Metabolite Endogenous Metabolite	Neurological Disease
3-Methoxytyramine-d₄ (hydrochloride) is the deuterium labeled 3-Methoxytyramine hydrochloride. 3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1)[1][2].

HY-B1196

Tiapride hydrochloride	Dopamine Receptor	Neurological Disease
Tiapride hydrochloride is a selective and orally active D₂ and D₃ dopamine receptors antagonist with IC₅₀ values of 110-320 nM and 180 nM, respectively. Tiapride hydrochloride shows anti-dyskinetic activity and anxiolytic activity. Tiapride hydrochloride is a neuroleptic agent.

HY-B0358A

Flunarizine dihydrochloride	Calcium Channel Sodium Channel Dopamine Receptor	Neurological Disease
Flunarizine dihydrochloride is a potent dual Na⁺/Ca²⁺ channel (T-type) blocker. Flunarizine dihydrochloride is a D₂ dopamine receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects.

HY-103414S

Raclopride-d5 hydrochloride	Dopamine Receptor	Neurological Disease
Raclopride-d₅ (hydrochloride) is the deuterium labeled Raclopride. Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively[1][2].

HY-A0077S1

Perphenazine-d4	Histamine Receptor Dopamine Receptor Autophagy Apoptosis Adrenergic Receptor 5-HT Receptor	Neurological Disease Endocrinology
Perphenazine-d₄ is the deuterium labeled Perphenazine. Perphenazine is a typical antipsychotic agent, inhibits 5-HT2Areceptor, Alpha-1A adrenergic receptor, Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor, with Ki values of 5.6, 10, 0.765/0.13, 3.4, and 8 nM, respectively.

HY-119486

Tavapadon PF-06649751; CVL-751	Dopamine Receptor	Neurological Disease
Tavapadon (PF-06649751) is an orally active and highly selective **dopamine D1/D5 receptor** partial agonist. Tavapadon is effective in enabling movement and reducing disability and has the potential for Parkinson's disease.

HY-15296S1

Cabergoline-d6 FCE-21336-d₆	Dopamine Receptor Autophagy	Endocrinology
Cabergoline-d₆ is deuterium labeled Cabergoline. Cabergoline is an ergot derived-dopamine D2-like receptor agonist that has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).

HY-103430

SKF-83566 hydrobromide	Dopamine Receptor 5-HT Receptor Adenylate Cyclase	Neurological Disease
SKF-83566 hydrobromide is a potent, blood-brain permeable and orally active *D1-like dopamine* receptor (D1DR)** antagonist and a weaker competitive antagonist at the vascular 5-HT₂ receptor (K_i=11 nM). SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC₅₀ of 5.7 μM. SKF-83566 also shows selective inhibition for adenylyl cyclase 2 (AC₂) over AC₁ and AC₅ in the isolated rabbit thoracic aorta. SKF-83566 can be used for the research of parkinson’s disease and nicotine craving alleviation.

HY-103430A

SKF-83566	Dopamine Receptor 5-HT Receptor Adenylate Cyclase	Neurological Disease
SKF-83566 is a potent, blood-brain permeable and orally active *D1-like dopamine* receptor (D1DR)** antagonist and a weaker competitive antagonist at the vascular 5-HT₂ receptor (K_i=11 nM). SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC₅₀ of 5.7 μM. SKF-83566 also shows selective inhibition for adenylyl cyclase 2 (AC2) over AC₁ and AC₅ in the isolated rabbit thoracic aorta. SKF-83566 can be used for research of parkinson’s disease and nicotine craving alleviation.

HY-116874

SKF 83822	Dopamine Receptor	Neurological Disease
SKF 83822 is an atypical agonist of **dopamine D1 receptor. SKF 83822 activates adenylyl cyclase, but not PLC. SKF 83822 is also proved to stimulate AC via cAMP** production. SKF 83822 can be used for research of schizophrenia.

HY-103406A

PNU-177864 hydrochloride	Dopamine Receptor	Neurological Disease
PNU-177864 hydrochloride is a potent, selective and orally active **dopamine D₃ receptor** antagonist. PNU-177864 hydrochloride is structurally consistent with a cationic amphiphilic agent (CAD) and induces phospholipidosis in vivo. PNU-177864 hydrochloride antischizophrenic activity.

HY-N0096

Rotundine (-)-Tetrahydropalmatine; L-Tetrahydropalmatine	5-HT Receptor Dopamine Receptor	Neurological Disease
Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC₅₀s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of 5-HT_1A with an IC₅₀ of 370 nM.

HY-13720AS

Pergolide-d7 mesylate Pergolide methanesulfonate-d₇; LY127809-d₇	Dopamine Receptor	Neurological Disease
Pergolide-d₇ (mesylate) is the deuterium labeled Pergolide mesylate. Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D1 and D2 receptors agonist. Pergolide mesylate can be used for Parkinson's disease and hyperprolactinaemia research[1][2].

HY-128121

MLS1547	Dopamine Receptor	Neurological Disease
MLS1547 is a highly efficacious *G protein-biased dopamine* D2 receptor (D2R) agonist (K_i=1.2 μM). MLS1547 stimulates D2R G protein-mediated signaling (EC₅₀*=0.37 μM in a calcium mobilization assay). MLS1547 acts as an antagonist for dopamine* (DA)-stimulated β-arrestin recruitment to the D2R (IC₅₀=9.9 μM).

HY-14827A

Zicronapine fumarate Lu 31-130 fumarate	Dopamine Receptor 5-HT Receptor	Neurological Disease
Zicronapine (Lu 31-130) fumarate is an antipsychotic medication with a strong pro-cognitive effect in animal models and the potential to treat a number of neurological and psychiatric diseases. Zicronapine (Lu 31-130) fumarate has potent antagonistic effects at dopamine D1/D2, and serotonin 5-HT2A receptors.

HY-13204B

Biperiden lactate KL 373 lactate	mAChR	Neurological Disease
Biperiden (KL 373) lactate is an orally active non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors. Biperiden (KL 373) lactate inhibits acetylcholine and enhances dopamine signaling in the central nervous system. Biperiden (KL 373) lactate has the potential for the research of Parkinson's disease and other related psychiatric disorders.

HY-15296S

Cabergoline-d5 FCE-21336-d₅	Dopamine Receptor Autophagy	Endocrinology
Cabergoline-d₅ is the deuterium labeled Cabergoline. Cabergoline is an ergot derived-dopamine D2-like receptor agonist that has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively)[1][2].

HY-B0410A

Pramipexole dihydrochloride hydrate	Dopamine Receptor	Neurological Disease
Pramipexole dihydrochloride hydrate is a selective and blood-brain barrier (BBB) penetrant **dopamine D2-type receptor agonist, with K_i*s of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D₂, D₃ and D₄ receptors*, respectively. Pramipexole dihydrochloride hydrate can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).

HY-B0410

Pramipexole	Dopamine Receptor	Neurological Disease
Pramipexole is a selective and blood-brain barrier (BBB) penetrant **dopamine D2-type receptor agonist, with K_i*s of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D₂, D₃ and D₄ receptors*, respectively. Pramipexole can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).

HY-17355

Pramipexole dihydrochloride	Dopamine Receptor	Neurological Disease
Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant **dopamine D2-type receptor agonist, with K_i*s of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D₂, D₃ and D₄ receptors*, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).

HY-146135

Tau-aggregation-IN-1	Microtubule/Tubulin Dopamine Receptor	Neurological Disease
Tau-aggregation-IN-1 (Compound D-519) is a tau441 protein aggregation inhibitor with an IC₅₀ of 21 µM. Tau-aggregation-IN-1 is also a dopamine D₂ and D₃ receptor agonist.

HY-P1329

CTOP	Opioid Receptor	Neurological Disease
CTOP is a potent and highly selective μ-opioid receptor antagonist. CTOP antagonizes the acute morphine-induced analgesic effect and hypermotility. CTOP enhances extracellular dopamine levels in the nucleus accumbens. CTOP dose-dependently enhances locomotor activity.

HY-13736A

Quinagolide hydrochloride CV205-502 hydrochloride	Dopamine Receptor Akt	Cancer Neurological Disease
Quinagolide hydrochloride (CV205-502 hydrochloride) is a selective and orally active dopamine D2 receptor agonist. Quinagolide hydrochloride is an inhibitor of prolactin. Quinagolide hydrochloride down-regulates AKT levels and its phosphorylation. Quinagolide hydrochloride shows antitumor effects, it can be used for the research of cancer.

HY-100290

5-HT1A modulator 1	5-HT Receptor	Neurological Disease
5-HT1A modulator 1 displays very high affinities for the 5HT_1A, adrenergic α₁ and **dopamine D₂ receptor with IC₅₀**s of 2 ±0.3 nM, 10 ± 3 nM and 40 ±9 nM, respectively.

HY-N6960

L-Stepholidine Stepholidine; (-)-Stepholidine; L-SPD	Dopamine Receptor	Neurological Disease
L-Stepholidine (Stepholidine) exhibits mixed **dopamine D1 receptor** agonist and D2 antagonist properties. L-Stepholidine has neuroprotective effect and inhibits Heroin-induced reinstatement. L-Stepholidine is a potential medication for the research of opiate addiction.

HY-N0927

(-)-Isocorypalmine Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine	Dopamine Receptor	Others
(-)-Isocorypalmine (Tetrahydrocolumbamine), isolated from the crude base fraction of Corydalis chaerophylla, is a **dopamine receptor** ligand. Recombinant CYP719A21 displays strict substrate specificity and high affinity (K_m=4.63 ± 0.71 μM) for (-)-Isocorypalmine.

HY-B0731A

Perospirone SM-9018 free base	5-HT Receptor Dopamine Receptor	Neurological Disease
Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT_2A receptor (K_i=0.6 nM) and dopamine D₂ receptor (K_i=1.4 nM), and also a partial agonist of 5-HT_1A receptor (K_i=2.9 nM). Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research.

HY-A0019

Paliperidone 9-Hydroxyrisperidone	Dopamine Receptor 5-HT Receptor Adrenergic Receptor	Neurological Disease
Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia.

HY-P1329A

CTOP TFA	Opioid Receptor	Neurological Disease
CTOP TFA is a potent and highly selective μ-opioid receptor antagonist. CTOP TFA antagonizes the acute analgesic effect and hypermotility. CTOP TFA enhances extracellular dopamine levels in the nucleus accumbens. CTOP TFA dose-dependently enhances locomotor activity.

HY-120511

KNT-127	Opioid Receptor	Neurological Disease
KNT-127 is a potent and selective δ-opioid receptor agonist effective by systemic administration. KNT-127 shows selectivity for the δ-receptor (K_i 0f 21.3, 0.16, 153 nM for opioid μ-, δ-, and κ-receptors, respectively). KNT-127 increases the release of dopamine and L-glutamate in the striatum, nucleus accumbens and median pre-frontal cortex. Antidepressant-like effects.

HY-A0077

Perphenazine	Dopamine Receptor Histamine Receptor 5-HT Receptor Adrenergic Receptor Apoptosis Autophagy	Cancer Endocrinology Inflammation/Immunology Neurological Disease
Perphenazine is an orally active **dopamine receptor** and histamine-1 receptor antagonist, with K_i values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively. Perphenazine also binds to Alpha-1A adrenergic receptor. Perphenazine inhibits cancer cell proliferation, and induces apoptosis. Perphenazine can be used in the research of mental disease, cancer, inflammation.

HY-17366A

Clozapine N-oxide dihydrochloride	mAChR Dopamine Receptor Drug Metabolite	Neurological Disease
Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a *human muscarinic designer receptors* (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride can cross the blood-brain barrier. Clozapine is a potent dopamine** antagonist and also a potent and selective muscarinic M4 receptor (EC₅₀=11 nM) agonist.

HY-17366

Clozapine N-oxide	mAChR Dopamine Receptor Drug Metabolite	Neurological Disease
Clozapine N-oxide is a major metabolite of Clozapine and a *human muscarinic designer receptors* (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can cross the blood-brain barrier. Clozapine is a potent dopamine** antagonist and also a potent and selective muscarinic M4 receptor (EC₅₀=11 nM) agonist.

HY-A0095A

Flibanserin hydrochloride BIMT-17 hydrochloride; BIMT-17BS hydrochloride	5-HT Receptor	Cancer Neurological Disease
Flibanserin (BIMT-17; BIMT-17BS) hydrochloride is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with K_i values of 1 nM and 49 nM, respectively. Flibanserin hydrochloride binds to dopamine D4 receptors with an K_i value of 4-24 nM. Flibanserin hydrochloride shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research^-.

HY-A0095

Flibanserin BIMT-17; BIMT-17BS	5-HT Receptor	Neurological Disease Cancer
Flibanserin (BIMT-17; BIMT-17BS) is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with K_i values of 1 nM and 49 nM, respectively. Flibanserin binds to dopamine D4 receptors with an K_i value of 4-24 nM. Flibanserin shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research^-.

HY-A0077A

Perphenazine dihydrochloride	Dopamine Receptor Histamine Receptor 5-HT Receptor Adrenergic Receptor Apoptosis Autophagy	Cancer Endocrinology Inflammation/Immunology Neurological Disease
Perphenazine dihydrochloride is an orally active **dopamine receptor** and histamine-1 receptor antagonist, with K_i values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively. Perphenazine dihydrochloride also binds to Alpha-1A adrenergic receptor. Perphenazine dihydrochloride inhibits cancer cell proliferation, and induces apoptosis. Perphenazine dihydrochloride can be used in the research of mental disease, cancer, inflammation.

HY-14539

Clozapine HF 1854	Dopamine Receptor mAChR Adrenergic Receptor 5-HT Receptor	Neurological Disease
Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a K_i of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with K_is of 9.5 nM and 4 nM, respectively. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC₅₀=11 nM).

HY-105793

Mazaticol	mAChR	Neurological Disease
Mazaticol is an anticholinergic agent. Mazaticol blocks the muscarinic acetylcholine receptors and cholinergic nerve activity. Mazaticol is a potent 3H-QNB and 3H-PZ binding inhibitor, can bind to the M2 receptors with high affinity. Mazaticol exhibits inhibitory effects on dopamine uptake in the striatal nerve terminal. Mazaticol can be used for parkinsonian syndrome research.

HY-117829

UNC9994	Dopamine Receptor 5-HT Receptor Histamine Receptor Arrestin	Neurological Disease
UNC9994, an analog of Aripiprazole, is a functionally selective β-arrestin-biased dopamine D2 receptor (D2R) agonist with EC₅₀ <10 nM for β-arrestin-2 recruitment to D2 receptors. UNC9994 is simultaneously partial agonists of β-arrestin-2 translocation and antagonists of G_i-regulated cAMP production. Antipsychotic Activity.

HY-14544

Quetiapine ICI204636	5-HT Receptor Dopamine Receptor	Neurological Disease
Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine is a **dopamine receptor antagonist with a pIC₅₀** of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pK_is of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects.

HY-B0031

Quetiapine hemifumarate	5-HT Receptor Dopamine Receptor	Neurological Disease
Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a **dopamine receptor antagonist with a pIC₅₀** of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pK_is of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects.

HY-14827

Zicronapine Lu 31-130	Dopamine Receptor 5-HT Receptor	Neurological Disease
Zicronapine is an antipsychotic medication with a strong pro-cognitive effect in animal models and the potential to treat a number of neurological and psychiatric diseases. Zicronapine has potent antagonistic effects at dopamine D1/D2, and serotonin 5-HT2A receptors.

HY-100822A

(S)-(-)-HA 966 (-)-HA 966	iGluR	Neurological Disease
(S)-(-)-HA 966 ((-)-HA 966), a γ-Hydroxybutyrate-like agent, is weakly active as an *NMDA*-receptor antagonist. (S)-(-)-HA 966 possesses muscle relaxant action and prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear.

HY-15780S

Brexpiprazole-d8 OPC-34712-d₈	5-HT Receptor Dopamine Receptor	Neurological Disease
Brexpiprazole-d₈ is a deuterium labeled Brexpiprazole (OPC-34712). Brexpiprazole, an atypical antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine receptor (Ki=0.12 nM and 0.3 nM, respectively). Brexpiprazole is also a 5-HT2A receptor antagonist (Ki=0.47 nM)[1][2].

HY-100971

Spiramide AMI-193	5-HT Receptor Dopamine Receptor	Neurological Disease
Spiramide (AMI-193) is a potent and selective antagonist of 5-HT₂ and **dopamine D2 receptor, with K_is of 2 nM and 3 nM, respectively. Spiramide has >2000-fold selectivity for 5-HT₂ versus 5-HT_1C (K_i*=4300 nM) receptors*. Spiramide exhibits antipsychotic activity.

HY-13575A

Blonanserin dihydrochloride AD-5423 dihydrochloride	5-HT Receptor Dopamine Receptor Adrenergic Receptor Sigma Receptor	Neurological Disease
Blonanserin dihydrochloride is a potent and orally active 5-HT_2A and **dopamine D2 receptor antagonist, with K_i** values of 0.812 and 0.142 nM, respectively. Blonanserin dihydrochloride is usually acts as an atypical antipsychotic agent, and can be used for the research of extrapyramidal symptoms, excessive sedation, or hypotension.

HY-17390A

Loxapine succinate	5-HT Receptor Dopamine Receptor	Infection Neurological Disease
Loxapine succinate is an orally active *dopamine* inhibitor, 5-HT receptor antagonist and also a dibenzoxazepine anti-psychotic agent. Loxapine can also suppresses bacterial efflux pump activity and inhibit intracellular multiple-antibiotic-resistant Salmonella enterica serovar Typhimurium in macrophages.

HY-17355S

Pramipexole-d7 dihydrochloride	Dopamine Receptor	Neurological Disease
Pramipexole-d₇ (dihydrochloride) is the deuterium labeled Pramipexole dihydrochloride. Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS)[1][2][3].

HY-B0410S1

Pramipexole-d5	Dopamine Receptor	Neurological Disease
Pramipexole-d₅ is the deuterium labeled Pramipexole[1]. Pramipexole is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS)[2][3][4].

HY-A0095S1

Flibanserin-d4-1 BIMT-17-d₄-1; BIMT-17BS-d₄-1	5-HT Receptor	Neurological Disease
Flibanserin-d₄-1 is deuterium labeled Flibanserin. Flibanserin (BIMT-17) is a full agonist of the serotonin 5-HT1A receptor (Ki=1 nM) and an antagonist of 5-HT2A (49 nM). Flibanserin binds to dopamine D4 receptors (4-24 nM), and has negligible affinity for a variety of other neurotransmitter receptors and ion channels. Flibanserin is efficacious in treating hypoactive sexual desire disorder (HSDD)[1][2].

HY-17355S1

Pramipexole-d5 dihydrochloride	Dopamine Receptor	Neurological Disease
Pramipexole-d₅ (dihydrochloride) is deuterium labeled Pramipexole (dihydrochloride). Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS)[1][2][3].

HY-A0019S

Paliperidone-d4	Dopamine Receptor 5-HT Receptor Adrenergic Receptor	Neurological Disease
Paliperidone-d₄ is the deuterium labeled Paliperidone. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia[1].

HY-21995

BGC20-761	5-HT Receptor Dopamine Receptor	Neurological Disease
BGC20-761 is a selecvtive 5-HT6 and **dopamine receptor** antagonist (human receptor K_i values: 5-HT6 (20 nM), 5-HT2A (69 nM), D2 (140 nM). BGC20-761, can enhance long-term memory. BGC20-761 has potential utility as an antipsychotic agent.

HY-B0032A

Lurasidone SM-13496	5-HT Receptor Dopamine Receptor	Neurological Disease
Lurasidone (SM-13496) is an antagonist of both dopamine D₂ and 5-HT₇ with IC₅₀s of 1.68 and 0.495 nM, respectively. Lurasidone (SM-13496) is also a partial agonist of 5-HT_1A receptor with an IC₅₀ of 6.75 nM.

HY-B0032

Lurasidone Hydrochloride SM-13496 Hydrochloride	5-HT Receptor Dopamine Receptor	Neurological Disease
Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is an antagonist of both dopamine D₂ and 5-HT₇ with IC₅₀s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is also a partial agonist of 5-HT_1A receptor with an IC₅₀ of 6.75 nM.

HY-116820

OS-3-106	Dopamine Receptor	Neurological Disease
OS-3-106 is a potent, BBB-penetrated and selective **dopamine D3 receptor (D3R) agonist. OS-3-106 binds with high affinity (K_i = 0.2 nM) at the D3R**. OS-3-106 can be used for psychostimulant addiction research.

HY-B0031S2

Quetiapine-d8 fumarate	5-HT Receptor Dopamine Receptor	Neurological Disease
Quetiapine-d₈ (fumarate) is the deuterium labeled Quetiapine. Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1][2].

HY-10847

SB-277011 SB-277011A	Dopamine Receptor	Neurological Disease
SB-277011 is a potent and delective dopamine D3 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively); brain penetrant.

HY-14543

Sertindole Lu 23-174	5-HT Receptor Dopamine Receptor Adrenergic Receptor Autophagy	Neurological Disease Cancer
Sertindole (Lu 23-174) is an orally active 5-HT_2A, 5-HT_2C, dopamine D₂, and αl-adrenergic receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple cancer cells.

HY-14546

Aripiprazole OPC-14597	5-HT Receptor Dopamine Receptor	Infection Inflammation/Immunology Neurological Disease
Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity **dopamine D2 receptor partial agonist. Aripiprazole is an inverse agonist at 5-HT2B and 5-HT2A** receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole can be used for the research of schizophrenia and COVID19.

HY-14546A

Aripiprazole monohydrate OPC-14597 monohydrate	5-HT Receptor Dopamine Receptor	Infection Inflammation/Immunology Neurological Disease
Aripiprazole (OPC-14597) monohydrate, an atypical antipsychotic, is a potent and high-affinity **dopamine D2 receptor partial agonist. Aripiprazole monohydrate is an inverse agonist at 5-HT2B and 5-HT2A** receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole monohydrate can be used for the research of schizophrenia and COVID19.

HY-130344

SKF83959	Dopamine Receptor Sigma Receptor	Neurological Disease
SKF83959 is a potent and selective dopamine D₁-like receptor partial agonist. SKF83959 K_i values for rat D₁, D₅, D₂ and D₃ receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 belongs to benzazepine family and has improvements on cognitive dysfunction. SKF83959 can be used for the research of Alzheimer's disease and depression.

HY-10349A

WAY-100635 Maleate	5-HT Receptor Dopamine Receptor	Neurological Disease
WAY-100635 maleate is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC₅₀ value of 0.91 nM and K_i value of 0.39 nM. WAY-100635 maleate has pIC₅₀ values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 maleate is also a potent **dopamine D₄ receptor** agonist.

HY-17355S2

Pramipexole-d7-1 dihydrochloride	Dopamine Receptor	Neurological Disease
Pramipexole-d₇-1 (dihydrochloride) is the deuterium labeled Pramipexole dihydrochloride[1]. Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS)[2][3][4].

HY-13575

Blonanserin AD-5423	5-HT Receptor Dopamine Receptor Adrenergic Receptor Sigma Receptor	Neurological Disease
Blonanserin (AD-5423) is a potent and orally active 5-HT_2A (K_i=0.812 nM) and dopamine D2 receptor (K_i =0.142 nM) antagonist. Blonanserin is usually acts as an atypical antipsychotic agent and can be used for the research of extrapyramidal symptoms, excessive sedation, or hypotension.

HY-12697

NGB 2904	Dopamine Receptor	Neurological Disease
NGB 2904 is a potent, selective, orally active and brain-penetrated antagonist of **dopamine D3 receptor, with a K_i** of 1.4 nM. NGB 2904 shows selectivity for D3 over D2, 5-HT2, α1, D4, D1 and D5 receptors (K_is=217, 223, 642, >5000, >10000 and >10000 nM, respectively). NGB 2904 antagonizes Quinpirole-stimulated mitogenesis.

HY-B0527A

Amitriptyline hydrochloride	Serotonin Transporter 5-HT Receptor Histamine Receptor mAChR Adrenergic Receptor Sodium Channel Trk Receptor	Neurological Disease
Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with K_is of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a K_i of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity.

HY-14327

FAUC 213	Dopamine Receptor	Neurological Disease
FAUC 213 is an orally active and highly selective dopamine D₄ receptor complete antagonist with a K_i of 2.2 nM for hD_4.4. FAUC 213 has less activity on D₂ and D₃ receptors (K_is of 3.4 μM, 5.3 μM for hD₂, hD₃, respectively). FAUC 213 can cross the blood-brain barrier (BBB). FAUC 213 exhibits atypical antipsychotic characteristic.

HY-12697A

NGB 2904 hydrochloride	Dopamine Receptor	Neurological Disease
NGB 2904 hydrochloride is a potent, selective, orally active and brain-penetrated antagonist of **dopamine D3 receptor, with a K_i** of 1.4 nM. NGB 2904 hydrochloride shows selectivity for D3 over D2, 5-HT2, α1, D4, D1 and D5 receptors (K_is=217, 223, 642, >5000, >10000 and >10000 nM, respectively). NGB 2904 hydrochloride antagonizes Quinpirole-stimulated mitogenesis.

HY-133152

Brexpiprazole S-oxide DM-3411	5-HT Receptor Dopamine Receptor	Neurological Disease
Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT_1A and **dopamine receptor with K_is of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT_2A** receptor antagonist with a K_i of 0.47 nM.

HY-B0031S3

Quetiapine-d8 hemifumarate	5-HT Receptor Dopamine Receptor	Neurological Disease
Quetiapine-d₈ (hemifumarate) is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1].

HY-B0031S4

Quetiapine hemifumarate-d8	Dopamine Receptor 5-HT Receptor	Neurological Disease
Quetiapine (hemifumarate)-d₈ is the deuterium labeled Quetiapine hemifumarate[1]. Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[2].

HY-15780A

Brexpiprazole hydrochloride OPC-34712 hydrochloride	5-HT Receptor Dopamine Receptor Adrenergic Receptor	Neurological Disease
Brexpiprazole (OPC-34712) hydrochloride, an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and **dopamine D_2L receptor with K_is of 0.12 nM and 0.3 nM, respectively. Brexpiprazole hydrochloride is also a 5-HT2A** receptor antagonist with a K_i of 0.47 nM. Brexpiprazole hydrochloride also shows potent antagonist activity at human noradrenergic α_1B (K_i=0.17 nM) and α_2C receptors (K_i=0.59 nM).

HY-B1033

Metergoline	5-HT Receptor Dopamine Receptor Sodium Channel	Neurological Disease
Metergoline is a serotonin (5-HT) receptor and **dopamine receptors antagonist, with pK_i*s of 8.64, 8.75 and 8.75 for 5-HT_2A, 5-HT_2B and 5-HT_2C, respectively. Metergoline is a high-affinity ligand for the h5-HT₇ receptor, with a K_i* of 16 nM. Metergoline is also a reversible neural Na⁺ channels inhibitor. Metergoline is commonly used for the research of seasonal affective disorder, prolactin hormone regulation.

HY-15780

Brexpiprazole OPC-34712	5-HT Receptor Dopamine Receptor Adrenergic Receptor	Neurological Disease
Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and **dopamine D_2L receptor with K_is of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A** receptor antagonist with a K_i of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α_1B (K_i=0.17 nM) and α_2C receptors (K_i=0.59 nM).

HY-B1423

Lobeline α-Lobeline; L-Lobeline	nAChR Dopamine Transporter	Neurological Disease
Lobeline (α-Lobeline; L-Lobeline), a lipophilic alkaloidal, is a nicotinic receptor agonist. Lobeline inhibits d-methamphetamine self-administration with no dopaminergic toxicity. Lobeline rescues d-amphetamine abuse induced addictive effect. Lobeline increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage.

HY-135096

Amitriptyline-d3 hydrochloride	Serotonin Transporter 5-HT Receptor Histamine Receptor mAChR Adrenergic Receptor Sodium Channel Trk Receptor	Neurological Disease
Amitriptyline-d3 hydrochloride is the deuterium labeled Amitriptyline (hydrochloride). Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with K_is of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a K_i of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity.

HY-B0527AS

Amitriptyline-d6 hydrochloride	Serotonin Transporter 5-HT Receptor Histamine Receptor mAChR Adrenergic Receptor Sodium Channel Trk Receptor	Neurological Disease
Amitriptyline-d₆ (hydrochloride) is the deuterium labeled Amitriptyline hydrochloride. Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity[1][2][3].

HY-N0925

Tetrahydroberberine Canadine	Dopamine Receptor	Neurological Disease
Tetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber; has micromolar affinity for dopamine D(2) (pK(i) = 6.08) and 5-HT(1A) (pK(i) = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors (5-HT(1B), 5-HT(1D), 5-HT(3), and 5-HT(4); pK(i) < 5.00).

HY-124270

Sibenadet hydrochloride AR-C68397AA	Dopamine Receptor Adrenergic Receptor	Inflammation/Immunology
Sibenadet hydrochloride (AR-C68397AA) is a dual D2 dopamine receptor, beta2-adrenoceptor agonist with bronchodilator activity. Investigation in animal models of key chronic obstructive pulmonary disease (COPD) symptoms has demonstrated that Sibenadet hydrochloride effectively inhibits sensory nerve activity, thereby reducing reflex cough, mucus production and tachypnoea.

HY-B0032AS

Lurasidone-d8 SM-13496-d₈	5-HT Receptor Dopamine Receptor	Neurological Disease
Lurasidone-d₈ is deuterium labeled Lurasidone. Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (SM-13496) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.

HY-B1371A

Spiperone hydrochloride Spiroperidol hydrochloride	Dopamine Receptor 5-HT Receptor Adrenergic Receptor Chloride Channel	Inflammation/Immunology Neurological Disease
Spiperone hydrochloride (Spiroperidol hydrochloride) is a selective **dopamine D₂ receptor (K_i** values of 0.06 nM, 0.6 nM, 0.08 nM, ~350 nM, ~3500 nM for D₂, D₃, D₄, D₁ and D₅ receptors, respectively) and 5-HT_2A/5-HT_1A receptor (K_is of 1 nM/49 nM) antagonist. Spiperone hydrochloride is also a selective α1B-adrenoceptor antagonist. Spiperone hydrochloride activates calcium-activated chloride channel (CaCC). Antipsychotic and anti-inflammatory activities.

HY-103412

SKF 83959 hydrobromide	Dopamine Receptor Sigma Receptor	Neurological Disease
SKF83959 hydrobromide is a potent and selective dopamine D₁-like receptor partial agonist. SKF83959 hydrobromide K_i values for rat D₁, D₅, D₂ and D₃ receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 hydrobromide is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 hydrobromide belongs to benzazepine family and has improvements on cognitive dysfunction. SKF83959 hydrobromide can be used for the research of Alzheimer's disease and depression.

HY-108400

SCH-23390 maleate R-(+)-SCH-23390 maleate	Dopamine Receptor 5-HT Receptor Potassium Channel	Neurological Disease
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective **dopamine D₁-like receptor antagonist with K_i*s of 0.2 nM and 0.3 nM for the D₁ and D₅ receptor, respectively. SCH-23390 maleate is a potent and high efficacy human 5-HT_2C receptor* agonist with a K_i of 9.3 nM. SCH-23390 maleate also binds with high affinity to the 5-HT₂ and 5-HT_1C receptors. SCH-23390 maleate inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC₅₀ of 268 nM.

HY-19545A

SCH-23390 hydrochloride R-(+)-SCH-23390 hydrochloride	Dopamine Receptor 5-HT Receptor Potassium Channel	Neurological Disease
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective **dopamine D₁-like receptor antagonist with K_i*s of 0.2 nM and 0.3 nM for the D₁ and D₅ receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT_2C receptor* agonist with a K_i of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT₂ and 5-HT_1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC₅₀ of 268 nM.

HY-10349

WAY-100635	5-HT Receptor Dopamine Receptor	Neurological Disease
WAY-100635 is a potent and selective 5-HT_1A Receptor antagonist with a pIC₅₀ of 8.87, an apparent pA₂ of 9.71. WAY-100635 is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC₅₀ value of 0.91 nM and K_i value of 0.39 nM. WAY-100635 has pIC₅₀ values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 is also a potent **dopamine D₄ receptor** agonist.

HY-100822

(R)-(+)-HA-966 (+)-HA-966	iGluR	Neurological Disease
(R)-(+)-HA-966 ((+)-HA-966) is a partial agonist/antagonist of glycine site of the N-methyl-D-aspartate (NMDA) receptor complex. (R)-(+)-HA-966 selectively blocks the activation of the mesolimbic dopamine system by amphetamine. (R)-(+)-HA-966 can cross the blood-brain barrier and has the potential for neuropathic and acute pain.

HY-15856B

Flupentixol dihydrochloride Flupenthixol dihydrochloride	Dopamine Receptor PI3K Apoptosis	Cancer Neurological Disease
Flupentixol is an orally active D₁/D₂ dopamine receptor antagonist and new PI3K inhibitor (PI3Kα IC₅₀=127 nM). Flupentixol shows anti-proliferative activity to cancer cells and induces apoptosis. Flupentixol can also be used in schizophrenia, anxiolytic and depressive research.

HY-14542A

Ziprasidone hydrochloride CP-88059 hydrochloride	5-HT Receptor Dopamine Receptor	Neurological Disease
Ziprasidone (CP-88059) hydrochloride is an orally active combined 5-HT and *dopamine* receptor antagonist. Ziprasidone hydrochloride has affinities for Rat D₂ (K_i=4.8 nM), 5-HT_2A (K_i=0.42 nM) and 5-HT_1A (K_i=3.4 nM).

HY-15856A

Flupentixol Flupenthixol	Dopamine Receptor PI3K Apoptosis	Neurological Disease
Flupentixol is an orally active D₁/D₂ dopamine receptor antagonist and new PI3K inhibitor (PI3Kα IC₅₀=127 nM). Flupentixol shows anti-proliferative activity to cancer cells and induces apoptosis. Flupentixol can also be used in schizophrenia, anxiolytic and depressive research.

HY-14690

Ecopipam SCH 39166	Dopamine Receptor 5-HT Receptor Adrenergic Receptor	Metabolic Disease Neurological Disease
Ecopipam (SCH 39166) is a potent, selective and orally active antagonist of **dopamine D1/D5 receptor, with K_i*s of 1.2 nM and 2.0 nM, respectively. Ecopipam shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor* (K_i=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam can be used for the research of schizophrenia and obesity.

HY-133152S

Brexpiprazole S-oxide-d8 DM-3411 d₈	5-HT Receptor Dopamine Receptor	Neurological Disease
Brexpiprazole S-oxide-d₈ is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM[1][2][3].

HY-14689

Ecopipam hydrochloride SCH 39166 hydrochloride	Dopamine Receptor 5-HT Receptor Adrenergic Receptor	Metabolic Disease Neurological Disease
Ecopipam (SCH 39166) hydrochloride is a potent, selective and orally active antagonist of **dopamine D1/D5 receptor, with K_i*s of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrochloride shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor* (K_i=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrochloride can be used for the research of schizophrenia and obesity.

HY-110033

Ecopipam hydrobromide SCH 39166 hydrobromide	Dopamine Receptor 5-HT Receptor Adrenergic Receptor	Metabolic Disease Neurological Disease
Ecopipam (SCH 39166) hydrobromide is a potent, selective and orally active antagonist of **dopamine D1/D5 receptor, with K_i*s of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrobromide shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor* (K_i=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrobromide can be used for the research of schizophrenia and obesity.

HY-100820

Sarizotan EMD 128130	5-HT Receptor Dopamine Receptor	Neurological Disease
Sarizotan (EMD 128130) is an orally active serotonin 5-HT_1A receptor and **dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC₅₀** values of 6.5 nM (rat 5-HT_1A), 0.1 nM (human 5-HT_1A), 15.1 nM (rat D₂), 17 nM (human D₂), 6.8 nM (human D₃) and 2.4 nM (human D_4.2), respectively.

HY-B1213A

Trimipramine	5-HT Receptor Bacterial	Neurological Disease
Trimipramine is a 5-HT receptor antagonist, with pK_i binding values of 6.39, 8.10, 4.66 for 5-HT_1C, 5-HT₂ and 5-HT_1A, respectively. Trimipramine is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC₅₀ values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively. Trimipramine has vascular activity and anxiolytic efficacy.

HY-B1213

Trimipramine maleate	5-HT Receptor Bacterial	Neurological Disease
Trimipramine maleate is a 5-HT receptor antagonist, with pK_i binding values of 6.39, 8.10, 4.66 for 5-HT_1C, 5-HT₂ and 5-HT_1A, respectively. Trimipramine maleate is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC₅₀ values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively. Trimipramine maleate has vascular activity and anxiolytic efficacy.

HY-15780S1

Brexpiprazole-d8-1 OPC-34712-d₈-1	Dopamine Receptor Adrenergic Receptor 5-HT Receptor	Neurological Disease
Brexpiprazole-d₈-1 is the deuterium labeled Brexpiprazole[1]. Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM)[2][3].

HY-14547

Bifeprunox	Dopamine Receptor 5-HT Receptor	Neurological Disease
Bifeprunox is a potent dopamine D2-like and 5-HT1A receptor partial agonist with pK_is of 7.19 and 8.83 for cortex 5-HT1A and striatum D2, and a pEC₅₀ of 6.37 for hippocampus 5-HT1A, respectively. Bifeprunox is an antipsychotic for the research of schizophrenia.

HY-14604

Xaliproden hydrochloride SR57746A; SR57746 hydrochloride	5-HT Receptor Dopamine Receptor	Neurological Disease
Xaliproden hydrochloride (SR57746A) is a potent, selective and orally active agonist of 5-HT_1A receptor, shows a high affinity for 5-HT_1A specific binding sites in the rat hippocampus (IC₅₀=3 nM). Xaliproden hydrochloride is also a selective antagonist of **dopamine D₂ receptor, has moderate affinity (IC₅₀**=0.1-1 μM). Xaliproden hydrochloride exhibits anti-depression and anti-anxiety effects, and it may possess therapeutic potential for the research of neurodegenerative diseases.

HY-136390

ML417	Dopamine Receptor	Neurological Disease
ML417 is a selective and brain penetrant *D3 dopamine* receptor (D3R) agonist, with an EC₅₀** of 38 nM. ML417 potently promotes D3R-mediated β-arrestin translocation, G protein mediated signaling, and pERK phosphorylation with minimal effects on other GPCR-mediated signaling. ML417 exhibits neuroprotection against toxin-induced neurodegeneration of dopaminergic neurons.

HY-103093

Zotepine	5-HT Receptor Histamine Receptor Adrenergic Receptor Dopamine Receptor	Neurological Disease
Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT_2A, 5-HT_2C, Histamine H₁, α₁-adrenergic and **Dopamine D₂ receptors, with K_d**s of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM and 8 nM, respectively. Zotepine exhibits antidepressive and anxiolytic effects in vivo.

HY-101341

RS 67333 hydrochloride	5-HT Receptor	Neurological Disease
RS 67333 hydrochloride is a potent and selective *5-HT4 receptor* (5-HT4R) partial agonist with a pK_i** of 8.7 in guinea-pig striatum. RS 67333 hydrochloride exhibits lower affinities at several other receptors including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1, D2 and muscarinic M1-M3 receptors. RS 67333 hydrochloride has neuroprotective effects, and can be used for Alzheimer's disease research.

HY-12363

U-69593	Opioid Receptor	Neurological Disease
U-69593 is a potent and selective κ1-opioid receptor agonist. U-69593 attenuates addictive agent-induced behavioral sensitization in the rat. U-69593 reduces anxiety and enhances spontaneous alternation memory in mice. U-69593 reduces calcium-dependent dialysate levels of dopamine and glutamate in the ventral striatum.

HY-B0965A

Thioridazine	Dopamine Receptor Apoptosis 5-HT Receptor Autophagy Bacterial	Neurological Disease
Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs).

HY-13409A

SB 242084 dihydrochloride	5-HT Receptor	Metabolic Disease Neurological Disease
SB 242084 dihydrochloride is a selective, competitive and high-affinity (pK_i=9.0) 5-HT_2C receptor antagonist (crosses the blood-brain barrier). SB 242084 dihydrochloride increases basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and dopamine release in the vomeronasal nucleus. SB 242084 dihydrochloride also increases mitochondrial gene expression and oxidative metabolism via 5-HT_2A receptor. SB 242084 dihydrochloride has good research potential in the negative symptoms of anxiety, depression and schizophrenia, as well as in acute organ damage.

HY-13409

SB 242084	5-HT Receptor	Metabolic Disease Neurological Disease
SB 242084 is a selective, competitive and high-affinity (pK_i=9.0) 5-HT_2C receptor antagonist (crosses the blood-brain barrier). SB 242084 increases basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and dopamine release in the vomeronasal nucleus. SB 242084 also increases mitochondrial gene expression and oxidative metabolism via 5-HT_2A receptor. SB 242084 has good research potential in the negative symptoms of anxiety, depression and schizophrenia, as well as in acute organ damage.

HY-B0965

Thioridazine hydrochloride	Dopamine Receptor Apoptosis 5-HT Receptor Autophagy Bacterial	Cancer Infection Neurological Disease
Thioridazine hydrochloride, an orally active antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine hydrochloride is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine hydrochloride shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs).

HY-119486A

(Rac)-Tavapadon (Rac)-PF-06649751; (Rac)-CVL-751	Dopamine Receptor Arrestin	Neurological Disease
(Rac)-Tavapadon ((Rac)-PF-06649751) is a potent and selective noncatechol **dopamine D1 receptor agonist. (Rac)-Tavapadon displays potent full agonism in the GS activation assay as well as partial agonism in the β-arrestin2** recruitment assay (GS-cAMP, EC₅₀=0.8 nM; β-arrestin2, EC₅₀=68 nM). (Rac)-Tavapadon has antiparkinsonian activity.

HY-N3945

Glaucine O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396	Phosphodiesterase (PDE) Calcium Channel Adrenergic Receptor Dopamine Receptor Influenza Virus	Infection Inflammation/Immunology
Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with K_is of 3.4 µM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca²⁺ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities.

HY-145628

CM398	Sigma Receptor	Inflammation/Immunology Neurological Disease
CM398 is a highly selective, orally active sigma-2 receptor ligand (K_i=0.43 nM), with high sigma-1/sigma-2 selectivity rato (1000-fold). CM398 shows notable affinity for dopamine (K_i=32.90 nM) and serotonin transporters (K_i=244.2 nM). CM398 shows promising anti-inflammatory analgesic effects in the formalin model of inflammatory pain in mice.

HY-111385

UNC9994 hydrochloride	Dopamine Receptor 5-HT Receptor Arrestin	Neurological Disease
UNC9994 hydrochloride is a functionally selective, β-arrestin–biased dopamine D₂ receptor (D₂R) agonist that selectively activates β-arrestin recruitment and signaling. UNC9994 hydrochloride shows a binding affinity with a K_i of 79 nM for D₂R. UNC9994 hydrochloride is also an antagonist of G_i-regulated cAMP production and partial agonist for D2R/β-arrestin-2 interactions. UNC9994 hydrochloride shows antipsychotic-like activity.

HY-125751

UCSF924	Dopamine Receptor	Neurological Disease
UCSF924 is a potent and specific dopamine D4 receptor (DRD4) partial agonist with a EC₅₀ of 4.2 nM. UCSF924 has a high-affinity with a K_i value of 3 nM for DRD4 and shows no measurable affinity for D2, D3 or the F261V/L328F D4 mutant. UCSF924 is a 7.4-fold bias toward arrestin over Gαi/o signaling, referenced to quinpirole.

HY-B0965AS

Thioridazine-d3 hydrochloride	Dopamine Receptor Apoptosis 5-HT Receptor Autophagy Bacterial	Neurological Disease
Thioridazine-d₃ (hydrochloride) is the deuterium labeled Thioridazine. Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs)[1][2][3][4].

HY-N2326

(±)-Anatoxin A fumarate	nAChR	Neurological Disease
(±)-Anatoxin A fumarate is a natural alkaloid isolated from freshwater cyanobacterium.(±)-Anatoxin A fumarate is a potent nicotinic receptor agonist and exhibits K_i values of 1.25 nM and 1.84 μM for binding to putative α4β2-type nAChR and α7-type nAChR in rat brain membranes, respectively. (±)-Anatoxin A fumarate stimulates [³H]-dopamine release from rat striatal synaptosomes (EC₅₀=134 nM).

HY-120920

UNC9995	Dopamine Receptor	Inflammation/Immunology
UNC9995 is a β-arrestin2-biased agonist of dopamine receptor Drd2. UNC9995 inhibits NLRP3 inflammasome activation by enhancing β-arrestin2-NLRP3 interaction, thus prevents neuronal degeneration. Futhermore, UNC9995 activates the Drd2/β-arrestin2 signaling to prevent inflammation-related genes transcription-induced by JAK/STAT3. UNC9995 improves depressive behavior in mouse model, and improves astrocytes dysfunctions.

HY-14541

Olanzapine LY170053	5-HT Receptor Dopamine Receptor mAChR Adrenergic Receptor Autophagy Mitophagy Apoptosis	Neurological Disease Cancer
Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (K_i=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (K_i=11 to 31 nM), muscarinic M1-5 (K_i=1.9-25 nM), and adrenergic α1 receptor (K_i=19 nM). Olanzapine is an atypical antipsychotic.

HY-14541S

Olanzapine-d3 LY170053-d₃	5-HT Receptor Dopamine Receptor mAChR Adrenergic Receptor Autophagy Mitophagy Apoptosis	Cancer Neurological Disease
Olanzapine-d₃ is the deuterium labeled Olanzapine. Olanzapine is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptors (Ki=19 nM). Olanzapine is an atypical antipsychotic[1][2].

HY-B1101

Pimethixene Pimetixene	5-HT Receptor Histamine Receptor	Neurological Disease Endocrinology
Pimethixene is antihistamine and antiserotonergic compound, acts as an antimigraine agent. Pimethixene is a highly potent antagonist of 5-HT_1A, 5-HT_2A, 5-HT_2B, 5-HT_2C, histamine H₁, dopamine D₂ and D_4.4 as well as muscarinic M₁ and M₂ receptors, with pK_is of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively.

HY-B1101A

Pimethixene maleate Pimetixene maleate	5-HT Receptor Histamine Receptor	Neurological Disease Endocrinology
Pimethixene maleate is antihistamine and antiserotonergic compound, acts as an antimigraine agent. Pimethixene maleate is a highly potent antagonist of 5-HT_1A, 5-HT_2A, 5-HT_2B, 5-HT_2C, histamine H₁, dopamine D₂ and D_4.4 as well as muscarinic M₁ and M₂ receptors, with pK_is of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively.

HY-B1658A

Frovatriptan succinate hydrate (R)-Frovatriptan succinate hydrate; SB 209509 succinate hydrate; VML 251 succinate hydrate	5-HT Receptor	Neurological Disease
Frovatriptan succinate hydrate ((R)-Frovatriptan succinate hydrate) is a potent, high affinity, selective and orally active 5-HT_1B (pK₅₀ of 8.2) and 5-HT_1D receptor agonist. Frovatriptan succinate hydrate exhibits >10-fold selectivity for 5-HT_1B and 5-HT_1D over 5-HT_1A, 5-HT_1F, and 5-HT₇ and >1000-fold selectivity over other 5-HT, dopamine, histamine H₁, and α1-adrenoceptor. Frovatriptan succinate hydrate has the potential for migraine research.

HY-B1658B

Frovatriptan succinate (R)-Frovatriptan succinate; SB 209509 succinate; VML 251 succinate	5-HT Receptor	Neurological Disease
Frovatriptan succinate ((R)-Frovatriptan succinate) is a potent, high affinity, selective and orally active 5-HT_1B (pK₅₀ of 8.2) and 5-HT_1D receptor agonist. Frovatriptan succinate exhibits >10-fold selectivity for 5-HT_1B and 5-HT_1D over 5-HT_1A, 5-HT_1F, and 5-HT₇ and >1000-fold selectivity over other 5-HT, dopamine, histamine H₁, and α1-adrenoceptor. Frovatriptan succinate has the potential for migraine research.

HY-B1658BS

Frovatriptan-d3 succinate (R)-Frovatriptan-d₃ (succinate); SB 209509-d₃ (succinate); VML 251-d₃ (succinate)	5-HT Receptor	Neurological Disease
Frovatriptan-d₃ (succinate) is deuterium labeled Frovatriptan (succinate). Frovatriptan succinate ((R)-Frovatriptan succinate) is a potent, high affinity, selective and orally active 5-HT1B (pK50 of 8.2) and 5-HT1D receptor agonist. Frovatriptan succinate exhibits >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7 and >1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptor. Frovatriptan succinate has the potential for migraine research[1][2].

HY-P3801

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) DiMe-C7	Neurokinin Receptor	Metabolic Disease Neurological Disease Others
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats.

Cat. No.	Product Name

HY-L062

Neurotransmitter Receptor Compound Library

1568 compounds

Neurotransmitter (NT) receptors, also known as neuroreceptors, are a broadly diverse group of membrane proteins that bind neurotransmitters for neuronal signaling. There are two major types of neurotransmitter receptors: ionotropic and metabotropic. Ionotropic receptors are ligand-gated ion channels, meaning that the receptor protein includes both a neurotransmitter binding site and an ion channel. The binding of a neurotransmitter molecule (the ligand) to the binding site induces a conformational change in the receptor structure, which opens, or gates, the ion channel. The term “metabotropic receptors” is typically used to refer to transmembrane G-protein-coupled receptors. Metabotropic receptors trigger second messenger-mediated effects within cells after neurotransmitter binding.

In some neurological diseases, the neurotransmitter receptor itself appears to be the target of the disease process. Many neuroactive drugs act by modifying neurotransmitter receptors. A better understanding of neurotransmitter receptor changes in disease may lead to improvements in therapy.

MCE designs a unique collection of 1568 compounds targeting a variety of neurotransmitter receptors. MCE Neurotransmitter Receptor Compound Library is a useful tool for neurological diseases drug discovery.

HY-L006

GPCR/G Protein Compound Library

2032 compounds

GPCRs are a large family of cell surface receptors that respond to a variety of external signals. Binding of a signaling molecule to a GPCR results in G protein activation, which in turn triggers the production of any number of second messengers. GPCRs play an important role in the human body, and increased understanding of these receptors has greatly affected modern medicine. In fact, researchers estimate that between one-third to one-half of all approved drugs act by binding to GPCRs. GPCRs are a large group of drug targets in drug discovery.

MCE provides a unique collection of 2032 small molecules targeting GPCRs that can be used in the screening for various GPCRs-related research and drug development projects.

HY-L013

Neuronal Signaling Compound Library

2199 compounds

Neuronal Signaling is involved in the regulation of the mechanisms of the central nervous system (CNS) such as its structure, function, genetics and physiology as well as how this can be applied to understand diseases of the nervous system. Every information processing system in the CNS is composed of neurons and glia, neurons have evolved unique capabilities for intracellular signaling (communication within the cell) and intercellular signaling (communication between cells). G protein-coupled receptors (GPCRs), including 5-HT receptor, histamine receptor, opioid receptor, etc. are the largest class of sensory proteins and are important therapeutic targets in Neuronal Signaling. Besides, Notch signaling, such as β- and γ-secretase, also plays multiple roles in the development of the CNS including regulating neural stem cell (NSC) proliferation, survival, self-renewal and differentiation. GPCR dysfunction caused by receptor mutations and environmental challenges contributes to many neurological diseases. Notch signaling in neurons, glia, and NSCs is also involved in pathological changes that occur in disorders such as stroke, Alzheimer's disease and CNS tumors. Thus, targeting Neuronal Signaling, such as notch signaling and GPCRs, can be used as therapeutic interventions for several different CNS disorders.

MCE designs a unique collection of 2199 Neuronal Signaling-related compounds that act as a useful tool for the research of neuronal regulation and neuronal diseases.

HY-L086

Neurodegenerative Disease-related Compound Library

1839 compounds

Neurodegenerative diseases are incurable and life-threatening conditions that result in progressive degeneration and/or death of nerve cells. Some common neurodegenerative diseases include Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Motor Neuron Disease (MND), Huntington’s Disease (HD), Spino-Cerebellar Ataxia (SCA), Spinal Muscular Atrophy (SMA), and Amyotrophic Lateral Sclerosis (ALS). Because the pathophysiology of neurodegenerative disorders is generally poorly understood, it is difficult to identify promising molecular targets and validate them. At the same time, about 85% of the drugs fail in clinical trials. Therefore, validating new targets and discovering new drugs to mitigate neurodegenerative disorders is need of the hour.

MCE offers a unique collection of 1839 compounds with anti-Neurodegenerative Diseases activities or targeting the unique targets of neurodegenerative diseases. MCE Neurodegenerative Disease-related Compound Library is a useful tool for exploring the mechanism of neurodegenerative diseases and discovering new drugs for neurodegenerative diseases.

HY-L085

Anti-Parkinson's Disease Compound Library

1111 compounds

Parkinson’s disease (PD), the second most common age-associated neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and the presence of α-synuclein-containing aggregates in the substantia nigra pars compacta (SNpc). Motor features such as tremor, rigidity, bradykinesia and postural instability are common traits of PD. To date, there is no treatment to stop or at least slow down the progression of the disease. The etiology and pathogenesis of PD is still elusive, however, a large body of evidence suggests a prominent role of oxidative stress, inflammation, apoptosis, mitochondrial dysfunction and proteasome dysfunction in the pathogenesis of PD.

MCE offers a unique collection of 1111 compounds with anti- Parkinson’s Disease activities or targeting the unique targets of PD. MCE Anti- Parkinson's Disease Compound Library is a useful tool for exploring the mechanism of PD and discovering new drugs for PD.

Cat. No.	Product Name	Target	Research Area

HY-107663

MIF-1 Pro-Leu-Gly-NH2; Melanostatin	Dopamine Receptor	Neurological Disease
MIF-1 (Melanostatin), an endogenous brain peptide, is a potent **dopamine receptor** allosteric modulator. MIF-1 inhibits melanin formation. MIF-1 blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB).

HY-107663A

MIF-1 TFA Pro-Leu-Gly-NH2 TFA; Melanostatin TFA	Dopamine Receptor	Neurological Disease
MIF-1 TFA (Melanostatin), an endogenous brain peptide, is a potent **dopamine receptor** allosteric modulator. MIF-1 TFA inhibits melanin formation. MIF-1 TFA blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 TFA accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB).

HY-P2687

Ularitide Urodilatin	Peptides	Cardiovascular Disease
Ularitide (Urodilatin), natriuretic peptide, is a vasodilator. Ularitide binds to and activates renal receptors. Ularitide also regulates renal dopamine metabolism Ularitide can be used in the research of heart failure.

HY-P0079

Neuromedin N Neuromedin N (rat, mouse, porcine, canine)	Dopamine Receptor	Neurological Disease
Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.

HY-P1083

Dynamin inhibitory peptide	Dynamin	Neurological Disease
Dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide blocks the dopamine D3 effect on GABAA receptors.

HY-W152604

Cyclo(glycyl-L-leucyl) Cyclo(leu-gly)	Dopamine Receptor	Neurological Disease
Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates **dopamine (DA) receptors** and attenuates dopaminergic supersensitivity. Cyclo(glycyl-L-leucyl) inhibits the development of Morphine induced pain relief as well as dopamine receptor supersensitivity in rats. Cyclo(glycyl-L-leucyl) has the potential for the prevention of tardive and/or L-DOPA (HY-N0304)-induced dyskinesias.

HY-P1083A

Dynamin inhibitory peptide TFA	Dynamin	Neurological Disease
Dynamin inhibitory peptide TFA competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide TFA blocks the dopamine D₃ effect on GABA_A receptors.

HY-P3294

Onzigolide BIM-23A760; TBR-760	Dopamine Receptor Somatostatin Receptor	Neurological Disease Cancer
Onzigolide (BIM-23A760), a chimeric dopamine-somatostatin compound, shows potent agonist activity at both DA type 2 (D2R) and SST type 2 (SSTR2) receptors.

HY-P1329

CTOP	Opioid Receptor	Neurological Disease
CTOP is a potent and highly selective μ-opioid receptor antagonist. CTOP antagonizes the acute morphine-induced analgesic effect and hypermotility. CTOP enhances extracellular dopamine levels in the nucleus accumbens. CTOP dose-dependently enhances locomotor activity.

HY-P3958

BIM-23027	Peptides	Neurological Disease
BIM-23027 is a selective agonist of sst₂ receptor (EC₅₀=0.32 nM), with similar effect to somatostatin (SRIF), a cyclic tetradecapeptide. BIM-23027 stimulates dopamine release, which is mediated by a Glu-dependent mechanism.

HY-P1329A

CTOP TFA	Opioid Receptor	Neurological Disease
CTOP TFA is a potent and highly selective μ-opioid receptor antagonist. CTOP TFA antagonizes the acute analgesic effect and hypermotility. CTOP TFA enhances extracellular dopamine levels in the nucleus accumbens. CTOP TFA dose-dependently enhances locomotor activity.

HY-P3801

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) DiMe-C7	Neurokinin Receptor	Metabolic Disease Neurological Disease Others
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats.

Cat. No.	Product Name	Target	Category

HY-103638

3-Methoxytyramine hydrochloride 3-O-methyl Dopamine hydrochloride	Drug Metabolite Endogenous Metabolite	Phenols Monophenols Source classification Endogenous metabolite
3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate *trace amine* associated receptor 1 (TAAR1**).

HY-N2003

D-Tetrahydropalmatine	Dopamine Receptor	Alkaloids Isoquinoline Alkaloids Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Plants Papaveraceae Corydalis yanhusuo W. T. Wang
D-Tetrahydropalmatine is an isoquinoline alkaloid, mainly in the genus Corydalis. D-Tetrahydropalmatine is a dopamine (DA) receptor antagonist with preferential affinity toward the D1 receptors. D-Tetrahydropalmatine is a potent organic cation transporter 1 (OCT1) inhibitor.

HY-N2197

Hirsuteine	nAChR	Indole Alkaloids Alkaloids Neurological Disease Disease Research Fields Classification of Application Fields Source classification Plants Rubiaceae Uncaria rhynchophylla (Miq.) Miq. ex Havil.
Hirsuteine is an indole alkaloid extracted from Uncaria rhynchophylla. Hirsuteine non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes.

HY-N7512

Asimilobine	Dopamine Receptor 5-HT Receptor Parasite	Isoquinoline Alkaloids Alkaloids Monophenols Phenols Infection Disease Research Fields Classification of Application Fields Source classification Plants Nymphaeaceae Nelumbo nucifera Gaertn.
Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a *dopamine* biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity.

HY-135525

Agroclavine	Dopamine Receptor Adrenergic Receptor	Structural Classification Indole Alkaloids Alkaloids
Agroclavine is a natural, clavine type of ergot alkaloid. Agroclavine is a D1 **dopamine receptor and α1-adrenoceptor** agonist. Agroclavine also has anticancer and antimicrobial activities.

HY-N0096

Rotundine (-)-Tetrahydropalmatine; L-Tetrahydropalmatine	5-HT Receptor Dopamine Receptor	Isoquinoline Alkaloids Alkaloids Source classification Plants Papaveraceae Corydalis yanhusuo W. T. Wang
Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC₅₀s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of 5-HT_1A with an IC₅₀ of 370 nM.

HY-N6960

L-Stepholidine Stepholidine; (-)-Stepholidine; L-SPD	Dopamine Receptor	Alkaloids Isoquinoline Alkaloids Source classification Plants Menispermaceae Stephania intermedia
L-Stepholidine (Stepholidine) exhibits mixed **dopamine D1 receptor** agonist and D2 antagonist properties. L-Stepholidine has neuroprotective effect and inhibits Heroin-induced reinstatement. L-Stepholidine is a potential medication for the research of opiate addiction.

HY-N0927

(-)-Isocorypalmine Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine	Dopamine Receptor	Alkaloids Isoquinoline Alkaloids Phenols Monophenols Classification of Application Fields Disease Research Fields Other Diseases Source classification Plants other families
(-)-Isocorypalmine (Tetrahydrocolumbamine), isolated from the crude base fraction of Corydalis chaerophylla, is a **dopamine receptor** ligand. Recombinant CYP719A21 displays strict substrate specificity and high affinity (K_m=4.63 ± 0.71 μM) for (-)-Isocorypalmine.

HY-A0019

Paliperidone 9-Hydroxyrisperidone	Dopamine Receptor 5-HT Receptor Adrenergic Receptor	Structural Classification Natural Products Endogenous metabolite Source classification
Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia.

HY-100971

Spiramide AMI-193	5-HT Receptor Dopamine Receptor	Alkaloids Piperidine Alkaloids Classification of Application Fields Disease Research Fields Neurological Disease Source classification Plants Rosaceae Spiraea japonica
Spiramide (AMI-193) is a potent and selective antagonist of 5-HT₂ and **dopamine D2 receptor, with K_is of 2 nM and 3 nM, respectively. Spiramide has >2000-fold selectivity for 5-HT₂ versus 5-HT_1C (K_i*=4300 nM) receptors*. Spiramide exhibits antipsychotic activity.

HY-B1423

Lobeline α-Lobeline; L-Lobeline	nAChR Dopamine Transporter	Structural Classification Alkaloids Other Alkaloids Lobelia chinensis Lour. Campanulaceae Plants Source classification
Lobeline (α-Lobeline; L-Lobeline), a lipophilic alkaloidal, is a nicotinic receptor agonist. Lobeline inhibits d-methamphetamine self-administration with no dopaminergic toxicity. Lobeline rescues d-amphetamine abuse induced addictive effect. Lobeline increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage.

HY-N0925

Tetrahydroberberine Canadine	Dopamine Receptor	Alkaloids Isoquinoline Alkaloids Source classification Plants Papaveraceae Corydalis yanhusuo W. T. Wang
Tetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber; has micromolar affinity for dopamine D(2) (pK(i) = 6.08) and 5-HT(1A) (pK(i) = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors (5-HT(1B), 5-HT(1D), 5-HT(3), and 5-HT(4); pK(i) < 5.00).

HY-N3945

Glaucine O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396	Phosphodiesterase (PDE) Calcium Channel Adrenergic Receptor Dopamine Receptor Influenza Virus	Isoquinoline Alkaloids Alkaloids Inflammation/Immunology Infection Disease Research Fields Classification of Application Fields Source classification Plants Papaveraceae Glaucium flavum other families
Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with K_is of 3.4 µM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca²⁺ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities.

Cat. No.	Product Name

HY-B1110S

Nomifensine-d3 maleate
Nomifensine-d₃ (maleate) is the deuterium labeled Nomifensine maleate. Nomifensine is a norepinephrine-dopamine reuptake inhibitor, increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters.

HY-15394S

(Rac)-Rotigotine-d7 hydrochloride

(Rac)-Rotigotine-d₇ (hydrochloride) is deuterium labeled (Rac)-Rotigotine (hydrochloride). (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-110232

Risperidone-d4
Risperidone-d₄ is the deuterium labeled Risperidone. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.

HY-14538S

Haloperidol D4

Haloperidol-d₄ is deuterium labeled haloperidol, and the latter is a potent dopamine D2 receptor antagonist.

HY-B0031S

Quetiapine-d4 fumarate
Quetiapine-d₄ (fumarate) is the deuterium labeled Quetiapine fumarate. Quetiapine fumarate is a 5-HT receptors agonist and a dopamine receptor antagonist. Antidepressant and anxiolytic effects[1].

HY-14538S1

Haloperidol (D4')

Haloperidol-d₄-1 is deuterium labeled haloperidol, and the latter is a potent dopamine D2 receptor antagonist.
HY-19489S

(±)-Levomepromazine-d6

(±)-Levomepromazine-d₆ is the deuterium labeled Methotrimeprazine, which is a D3 dopamine and Histamine H1 receptor antagonist.

HY-14545S

Amisulpride-d5
Amisulpride-d₅ is the deuterium labeled Amisulpride. Amisulpride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively[1][2].

HY-B0031S1

Quetiapine-d4 hemifumarate
Quetiapine-d₄ (hemifumarate) is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a 5-HT receptors agonist and a dopamine receptor antagonist. Antidepressant and anxiolytic effects[1].

HY-14545S1

Amisulpride-d5 N-Oxide
Amisulpride-d₅ N-Oxide is the deuterium labeled Amisulpride. Amisulpride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively[1][2].

HY-B0411S

Domperidone-d6
Domperidone-d₆ is the deuterium labeled Domperidone. Domperidone (R33812) is a selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1][2].

HY-12987S1

Pimozide-d5 N-Oxide
Pimozide-d₅ N-Oxide is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5[1][2].

HY-12987S

Pimozide-d4
Pimozide-d₄ is a deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5[1][2][3].

HY-A0077AS

Perphenazine-d8 dihydrochloride

Perphenazine-d₈ (dihydrochloride) is the deuterium labeled Perphenazine, which is a typical antipsychotic agent(5-HT, Dopamine receptor ligand).
HY-A0007S

Rotigotine-d7 hydrochloride

Rotigotine-d₇ (hydrochloride) is the deuterium labeled Rotigotine(N-0923), which is a dopamine D2 and D3 receptor agonist.

HY-12987S2

Pimozide-d4-1
Pimozide-d₄-1 is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5[1][2][3][4].

HY-14538S3

Haloperidol-13C6

Haloperidol-¹³C₆ is the ¹³C₆ labeled Haloperidol. Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic.

HY-B0732S

Itopride-d6 hydrochloride
Itopride-d₆ (hydrochloride) is deuterium labeled Itopride (hydrochloride). Itopride hydrochloride (HSR803), a gastroprokinetic Benzamide (HY-Z0283) derivative, is an inhibitor of acetylcholinesterase (AChE) and dopamine D2 receptor[1][2].

HY-16567S

Asenapine-13C,d3 hydrochloride
Asenapine-¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled Asenapine (hydrochloride). Asenapine hydrochloride, an antipsychotic, is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and Dopamine (D2, D3, D4) receptor antagonist with Ki values of 0.03-4.0 nM for 5-HT and 1.3, 0.42, 1.1 nM for Dopamine receptor, respectively.

HY-14538S2

Haloperidol-d4 N-Oxide

Haloperidol-d₄ N-Oxide is the deuterium labeled Haloperidol. Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic[1][2].

HY-14542S

Ziprasidone-d8
Ziprasidone-d₈8 is deuterium labeled Ziprasidone, which is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity.

HY-W040146S

Propionylpromazine-d6 hydrochloride
Propionylpromazine-d₆ (hydrochloride) is the deuterium labeled Propionylpromazine hydrochloride. Propionylpromazine hydrochloride (Propiopromazine hydrochloride), a dopamine receptor D2 (DRD2) antagonist, can be used in the research of Parkinson disease[1].

HY-13575S1

Blonanserin-d5

Blonanserin-d₅ is a deuterium labeled Blonanserin. Blonanserin is a dopamine D2/5-HT2 receptor antagonist and an atypical antipsychotic[1][2].
HY-13575S

Blonanserin D8

Blonanserin-d₈ is a deuterium labeled Blonanserin. Blonanserin is a dopamine D2/5-HT2 receptor antagonist and an atypical antipsychotic[1][2].

HY-G0014S

Quetiapine Sulfoxide-d8
Quetiapine Sulfoxide-d₈ is the deuterium labeled Quetiapine sulfoxide. Quetiapine sulfoxide (Quetiapine S-oxide) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic[1]. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist[1][2].

HY-A0163S

Zuclopenthixol-d4 succinate salt
Zuclopenthixol-d₄ (succinate) is the deuterium labeled Zuclopenthixol. Zuclopenthixol is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist[1][2].

HY-B0274AS

Chlorprothixene-d6 hydrochloride
Chlorprothixene-d₆ (hydrochloride) is the deuterium labeled Chlorprothixene hydrochloride. Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity[1].

HY-B0520AS1

Benztropine-d3 mesylate

Benztropine-d₃ (mesylate) is the deuterium labeled Benztropine mesylate[1]. Benztropine mesylate (Benzatropine mesylate) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects[2][3].

HY-A0125AS

Alizapride-13C,d3 hydrochloride
Alizapride-¹³C,d₃ (hydrochloride) is deuterium labeled Alizapride (hydrochloride). Alizapride hydrochloride is a dopamine receptor antagonist with prokinetic and antiemetic effects which can also be used in the treatment of nausea and vomiting, including postoperative nausea and vomiting.

HY-B0520AS

Benztropine-13C,d3 mesylate

Benztropine-¹³C,d₃ (mesylate) is the ¹³C- and deuterium labeled Benztropine (mesylate). Benztropine mesylate (Benzatropine mesylate) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects[1][2].

HY-103638S

3-Methoxytyramine-d4 hydrochloride
3-Methoxytyramine-d₄ (hydrochloride) is the deuterium labeled 3-Methoxytyramine hydrochloride. 3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1)[1][2].

HY-103414S

Raclopride-d5 hydrochloride
Raclopride-d₅ (hydrochloride) is the deuterium labeled Raclopride. Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively[1][2].

HY-A0077S1

Perphenazine-d4
Perphenazine-d₄ is the deuterium labeled Perphenazine. Perphenazine is a typical antipsychotic agent, inhibits 5-HT2Areceptor, Alpha-1A adrenergic receptor, Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor, with Ki values of 5.6, 10, 0.765/0.13, 3.4, and 8 nM, respectively.

HY-15296S1

Cabergoline-d6
Cabergoline-d₆ is deuterium labeled Cabergoline. Cabergoline is an ergot derived-dopamine D2-like receptor agonist that has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).

HY-13720AS

Pergolide-d7 mesylate
Pergolide-d₇ (mesylate) is the deuterium labeled Pergolide mesylate. Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D1 and D2 receptors agonist. Pergolide mesylate can be used for Parkinson's disease and hyperprolactinaemia research[1][2].

HY-15296S

Cabergoline-d5
Cabergoline-d₅ is the deuterium labeled Cabergoline. Cabergoline is an ergot derived-dopamine D2-like receptor agonist that has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively)[1][2].

HY-15780S

Brexpiprazole-d8
Brexpiprazole-d₈ is a deuterium labeled Brexpiprazole (OPC-34712). Brexpiprazole, an atypical antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine receptor (Ki=0.12 nM and 0.3 nM, respectively). Brexpiprazole is also a 5-HT2A receptor antagonist (Ki=0.47 nM)[1][2].

HY-17355S

Pramipexole-d7 dihydrochloride

Pramipexole-d₇ (dihydrochloride) is the deuterium labeled Pramipexole dihydrochloride. Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS)[1][2][3].

HY-B0410S1

Pramipexole-d5
Pramipexole-d₅ is the deuterium labeled Pramipexole[1]. Pramipexole is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS)[2][3][4].

HY-A0095S1

Flibanserin-d4-1

Flibanserin-d₄-1 is deuterium labeled Flibanserin. Flibanserin (BIMT-17) is a full agonist of the serotonin 5-HT1A receptor (Ki=1 nM) and an antagonist of 5-HT2A (49 nM). Flibanserin binds to dopamine D4 receptors (4-24 nM), and has negligible affinity for a variety of other neurotransmitter receptors and ion channels. Flibanserin is efficacious in treating hypoactive sexual desire disorder (HSDD)[1][2].

HY-17355S1

Pramipexole-d5 dihydrochloride

Pramipexole-d₅ (dihydrochloride) is deuterium labeled Pramipexole (dihydrochloride). Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS)[1][2][3].

HY-A0019S

Paliperidone-d4
Paliperidone-d₄ is the deuterium labeled Paliperidone. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia[1].

HY-B0031S2

Quetiapine-d8 fumarate

Quetiapine-d₈ (fumarate) is the deuterium labeled Quetiapine. Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1][2].

HY-17355S2

Pramipexole-d7-1 dihydrochloride

Pramipexole-d₇-1 (dihydrochloride) is the deuterium labeled Pramipexole dihydrochloride[1]. Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS)[2][3][4].

HY-B0031S3

Quetiapine-d8 hemifumarate

Quetiapine-d₈ (hemifumarate) is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1].

HY-B0031S4

Quetiapine hemifumarate-d8

Quetiapine (hemifumarate)-d₈ is the deuterium labeled Quetiapine hemifumarate[1]. Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[2].

HY-B0527AS

Amitriptyline-d6 hydrochloride

Amitriptyline-d₆ (hydrochloride) is the deuterium labeled Amitriptyline hydrochloride. Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity[1][2][3].

HY-B0032AS

Lurasidone-d8
Lurasidone-d₈ is deuterium labeled Lurasidone. Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (SM-13496) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.

HY-133152S

Brexpiprazole S-oxide-d8

Brexpiprazole S-oxide-d₈ is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM[1][2][3].

HY-15780S1

Brexpiprazole-d8-1

Brexpiprazole-d₈-1 is the deuterium labeled Brexpiprazole[1]. Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM)[2][3].

HY-B0965AS

Thioridazine-d3 hydrochloride

Thioridazine-d₃ (hydrochloride) is the deuterium labeled Thioridazine. Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs)[1][2][3][4].

HY-14541S

Olanzapine-d3
Olanzapine-d₃ is the deuterium labeled Olanzapine. Olanzapine is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptors (Ki=19 nM). Olanzapine is an atypical antipsychotic[1][2].

HY-B1658BS

Frovatriptan-d3 succinate

Frovatriptan-d₃ (succinate) is deuterium labeled Frovatriptan (succinate). Frovatriptan succinate ((R)-Frovatriptan succinate) is a potent, high affinity, selective and orally active 5-HT1B (pK50 of 8.2) and 5-HT1D receptor agonist. Frovatriptan succinate exhibits >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7 and >1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptor. Frovatriptan succinate has the potential for migraine research[1][2].

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