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Isoforms Recommended:	DOT1L

Results for "

Dot1L

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) E3 Ligase Ligand-Linker Conjugates (1) Histone Methyltransferase (14) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (15)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-135127

Dot1L-IN-4

Histone Methyltransferase Cancer

Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC_{50 SPA DOT1L} of 0.11 nM ^[1].

Dot1L-IN-4	Histone Methyltransferase	Cancer
Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC_{50 SPA DOT1L} of 0.11 nM ^[1].

HY-RS03942

DOT1L Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DOT1L Human Pre-designed siRNA Set A contains three designed siRNAs for DOT1L gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DOT1L Human Pre-designed siRNA Set A DOT1L Human Pre-designed siRNA Set A

HY-RS03943

Dot1l Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dot1l Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dot1l gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dot1l Mouse Pre-designed siRNA Set A Dot1l Mouse Pre-designed siRNA Set A

HY-RS03944

Dot1l Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dot1l Rat Pre-designed siRNA Set A contains three designed siRNAs for Dot1l gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dot1l Rat Pre-designed siRNA Set A Dot1l Rat Pre-designed siRNA Set A

HY-135129

Dot1L-IN-6

Histone Methyltransferase Cancer

Dot1L-IN-6 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC_{50 SPA DOT1L} of 0.19 nM ^[1].
HY-135128

Dot1L-IN-5

Histone Methyltransferase Cancer

Dot1L-IN-5 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC₅₀ of 0.17 nM ^[1].

Dot1L-IN-6	Histone Methyltransferase	Cancer
Dot1L-IN-6 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC_{50 SPA DOT1L} of 0.19 nM ^[1].

Dot1L-IN-5	Histone Methyltransferase	Cancer
Dot1L-IN-5 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC₅₀ of 0.17 nM ^[1].

HY-146724

Dot1L-IN-7	Histone Methyltransferase	Cancer
Dot1L-IN-7 (compound 25) is a potent and selective disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 of 1.0 μM. Dot1L-IN-7 selectively killed Mixed Lineage Leukemia (MLL)-AF9 without showing any effect on the growth of E2A-HLF cells ^[1].

HY-101520

Dot1L-IN-1	Histone Methyltransferase	Cancer
Dot1L-IN-1 is a highly potent and selective *Dot1L* inhibitor with a K_i of 2 pM and an IC₅₀ of <0.1 nM. Dot1L-IN-1 potently suppresses H3K79 dimethylation (IC₅₀=3 nM), as well as the activity of the HoxA9 promoter (IC₅₀=17 nM) in HeLa and Molm-13 cells, respectively ^[1].

HY-101520A

Dot1L-IN-1 TFA	Histone Methyltransferase	Cancer
Dot1L-IN-1 TFA is a highly potent and selective *Dot1L* inhibitor with a K_i of 2 pM and an IC₅₀ of <0.1 nM. Dot1L-IN-1 TFA potently suppresses H3K79 dimethylation (IC₅₀=3 nM), as well as the activity of the HoxA9 promoter (IC₅₀=17 nM) in HeLa and Molm-13 cells, respectively ^[1].

HY-111390

Dot1L-IN-2	Histone Methyltransferase	Cancer
Dot1L-IN-2 is a potent, selective and orally bioavailable inhibitor of *Dot1L* (a histone methyltransferase), with an IC₅₀ and K_i of 0.4 nM and 0.08 nM, respectively.

HY-146187

Antitumor agent-69	Histone Methyltransferase	Cancer
Antitumor agent-69 (compound 12) is a potent inhibitor of protein-protein interaction between *DOT1L* and MLL-AF9/MLL-ENL, with K_is of 9 nM and 109 nM for AF9 and ENL, respectively. Antitumor agent-69 exhibits anticancer cellular activitiy ^[1].

HY-15227

EPZ004777

5+ Cited Publications

Histone Methyltransferase Apoptosis Cancer

EPZ004777 is a potent, selective DOT1L inhibitor with an IC₅₀ of 0.4 nM.
HY-15227A

EPZ004777 hydrochloride

5+ Cited Publications

Histone Methyltransferase Apoptosis Cancer

EPZ004777 hydrochloride is a potent, selective DOT1L inhibitor with an IC₅₀ of 0.4 nM.

EPZ004777 5+ Cited Publications	Histone Methyltransferase Apoptosis	Cancer
EPZ004777 is a potent, selective *DOT1L* inhibitor with an IC₅₀ of 0.4 nM.

EPZ004777 hydrochloride 5+ Cited Publications	Histone Methyltransferase Apoptosis	Cancer
EPZ004777 hydrochloride is a potent, selective *DOT1L* inhibitor with an IC₅₀ of 0.4 nM.

HY-15593

Pinometostat Maximum Cited Publications 19 Publications Verification EPZ-5676	Histone Methyltransferase	Cancer
Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor with a K_i of 80 pM.

HY-145813

MU1656	Histone Methyltransferase	Cancer
MU1656 is a potent and selective inhibitor of histone methyltransferase DOT1L, with an IC₅₀ of 2 nM. MU1656 can be used for the research of hematological malignancies ^[1].

HY-153959

Thalidomide-O-amido-C11-COOH	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-O-amido-C11-COOH (compound IMiD acid 1) is an E3 ligase ligand and linker CRBN (Cereblon) conjugate. Thalidomide-O-amido-C11-COOH can be used to synthesize PROTAC that target the degradation of *DOT1L* ^[1].

HY-121093

DC-S239	Histone Methyltransferase	Cancer
DC-S239 is a selective histone methyltransferase SET7 inhibitor with an IC₅₀ value of 4.59 μM. DC-S239 also displays selectivity for DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a. DC-S239 has anticancer activity ^[1].

HY-15650

SGC0946 5+ Cited Publications	Histone Methyltransferase	Cancer
SGC0946 is a selective *DOT1L*H3K79 methyltransferase) inhibitor, with an IC₅₀ of 0.3 nM. SGC0946 results in G1 arrest, inhibits potential of cell self-renewal and metastatic, also induces cell differentiation. SGC0946 can be used in studies of leukemia and solid tumors and also serve as a probe to further investigate the cellular mechanism of *DOT1L* in both normal and diseased cells ^[1] .

Cat. No.	Compare	Product Name	Species	Source

HY-P75283

	DOT1L Protein, Human Histone H3-K79 methyltransferase; H3-K79-HMTase; Dot1L; KIAA1814; KMT4	Human	E. coli
	The DOT1L protein, a histone methyltransferase, methylates lysine-79 of histone H3. It shows high activity against nucleosomes but not free core histones. It is broadly expressed, particularly in tissues like the testis, bone marrow, and 22 other tissues. DOT1L Protein, Human is the recombinant human-derived DOT1L protein, expressed by E. coli , with tag free. The total length of DOT1L Protein, Human is 415 a.a., with molecular weight of ~50 kDa.


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