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Results for "

E-1

" in MCE Product Catalog:

77

Inhibitors & Agonists

2

Screening Libraries

5

Peptides

14

Natural
Products

31

Recombinant Proteins

19

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas
  • HY-B0234
    Estrone

    E1; Oestrone

    		 Estrogen Receptor/ERR Endogenous Metabolite Endocrinology Cancer
    Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells.
  • HY-B0234S1
    Estrone-d2

    E1-d2; Oestrone-d2

    		 Estrogen Receptor/ERR Endogenous Metabolite Endocrinology Cancer
    Estrone-d2 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
  • HY-B0234S2
    Estrone-d4

    E1-d4; Oestrone-d4

    		 Estrogen Receptor/ERR Endogenous Metabolite Endocrinology Cancer
    Estrone-d4 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
  • HY-B0234S4
    Estrone-d2-1

    E1-d2-1; Oestrone-d2-1

    		 Estrogen Receptor/ERR Endogenous Metabolite
    Estrone-d2-1 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
  • HY-B0234S
    Estrone-13C3

    E1-13C3; Oestrone-13C3

    		 Estrogen Receptor/ERR Endogenous Metabolite Endocrinology Cancer
    Estrone- 13C3 is the 13C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
  • HY-B0234S3
    Estrone-13C2

    E1-13C2; Oestrone-13C2

    		 Estrogen Receptor/ERR Endogenous Metabolite Endocrinology Cancer
    Estrone- 13C2 is the 13C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
  • HY-116463
    E1R

    		Sigma Receptor Neurological Disease
    E1R is a positive allosteric modulator of sigma-1 receptors (Sig1R PAM) with cognition-enhancing activity.
  • HY-114041
    Resolvin E1

    RvE1

    		 Endogenous Metabolite Inflammation/Immunology
    Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production.
  • HY-B0131
    Prostaglandin E1

    Alprostadil; PGE1

    		 Prostaglandin Receptor Endogenous Metabolite Endocrinology Cardiovascular Disease
    Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases.
  • HY-N6853
    Mogroside I E1

    		Others Cancer Metabolic Disease
    Mogroside I E1 is a triterpenoid glycoside and a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities.
  • HY-B0131S
    Prostaglandin E1-d4

    		Prostaglandin Receptor Endogenous Metabolite Endocrinology Cardiovascular Disease
    Prostaglandin E1-d4 is the deuterium labeled Prostaglandin E1. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases[1][2][3].
  • HY-P2319
    OVA-E1 peptide

    		p38 MAPK JNK Inflammation/Immunology
    OVA-E1 peptide, is an antagonist variant of SIINFEKL [OVA (257-264). OVA-E1 peptide, activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes.
  • HY-P2319A
    OVA-E1 peptide TFA

    		p38 MAPK JNK Inflammation/Immunology
    OVA-E1 peptide TFA, is an antagonist variant of SIINFEKL [OVA (257-264). OVA-E1 peptide, activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes.
  • HY-B0131S2
    Prostaglandin E1-d9

    Alprostadil-d9; PGE1-d9

    		 Isotope-Labeled Compounds Prostaglandin Receptor Endogenous Metabolite Endocrinology Cardiovascular Disease
    Prostaglandin E1-d9 is deuterium labeled Prostaglandin E1.Prostaglandin E1 is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inh
  • HY-114041S1
    Resolvin E1-d4-1

    RvE1-d4-1

    		 Endogenous Metabolite Inflammation/Immunology
    Resolvin E1-d4-1 is the deuterium labeled Resolvin E1. Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production[1][2].
  • HY-139968S
    13,14-Dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1-d4

    		Isotope-Labeled Compounds Others
    13,14-Dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1-d4 is the deuterium labeled 13,14-Dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1[1].
  • HY-152267
    Ubiquitination-IN-3

    		E1/E2/E3 Enzyme Cancer
    Ubiquitination-IN-3 is a potent E1-E2 protein−protein interactions (PPI) inhibitor. Ubiquitination-IN-3 has a Kd value of 0.72 μM for ubiquitin E1 (Uba1). Ubiquitination-IN-3 inhibits blocks ubiquitin transfer from E1 to E2. Ubiquitination-IN-3 can be used in research of cancer.
  • HY-152266
    Ubiquitination-IN-2

    		E1/E2/E3 Enzyme Cancer
    Ubiquitination-IN-2 is a potent E1-E2 protein−protein interactions (PPI) inhibitor. Ubiquitination-IN-2 has a Kd value of 0.72 μM for ubiquitin E1 (Uba1). Ubiquitination-IN-2 inhibits blocks ubiquitin transfer from E1 to E2. Ubiquitination-IN-2 can be used in research of cancer.
  • HY-N7148S
    α-Vitamin E-d6

    (+)-α-Tocopherol-d6; D-α-Tocopherol-d6

    		 Isotope-Labeled Compounds Endogenous Metabolite COX Others
    α-Vitamin E-d6 is the deuterium labeled α-Vitamin E[1].
  • HY-144427S
    Vitamin E-13C2,d6

    		Isotope-Labeled Compounds Others
    Vitamin E- 13C2,d6 is a 13C-labeled and deuterium labeled Vitamin E[1].
  • HY-101477
    Ornoprostil

    		Others Inflammation/Immunology
    Ornoprostil is a prostaglandin E1 analogue. Ornoprostil is orally active and can be used for gastric ulcer research.
  • HY-N11038
    Drynachromoside A

    		Others Others
    Drynachromoside A is a chromone glycoside. Drynachromoside A has biochemical effects on the osteoblastic (MC3T3-E1 cells) proliferation activities.
  • HY-W101495S
    Boc-Leu-OH·H2O-13C

    		Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease Inflammation/Immunology
    Boc-Leu-OH·H2O- 13C is a 13C-labeled γ-Tocotrienol. γ-Tocotrienol is an active form of vitamin E[1].
  • HY-B0610
    Misoprostol

    SC-29333

    		 Prostaglandin Receptor Endocrinology
    Misoprostol (SC-29333) is an orally active synthetic prostaglandin E1 (PGE1) analog that is used for gastric ulcers research.
  • HY-N4119
    Neoeriocitrin

    		Cholinesterase (ChE) Neurological Disease
    Neoeriocitrin, isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is a potent acetylcholinesterase (AChE) inhibitor.
  • HY-23337S
    1-Methyl-3-((tetrahydrofuran-3-yl)methyl)urea-d3

    		Isotope-Labeled Compounds Others
    1-Methyl-3-((tetrahydrofuran-3-yl)methyl)urea-d3 is the deuterium labeled γ-Tocotrienol. γ-Tocotrienol is an active form of vitamin E[1].
  • HY-13296
    PYR-41

    		E1/E2/E3 Enzyme Apoptosis Cancer
    PYR-41 is a selective and cell permeable inhibitor of ubiquitin-activating enzyme E1 with an IC50 of < 10 μM, with little activity at E2 and E3.
  • HY-125568
    Pyridoxatin

    		Others Others
    Pyridoxatin is a free radical scavenger of microbial origin. Pyridoxatin is isolated from a fungus culture identified as Acremonium sp. BX86. Pyridoxatin inhibits lipid peroxidation induced by free radicals in rat liver microsomes free from vitamin E.
  • HY-114304
    COH000

    		E1/E2/E3 Enzyme Cancer
    COH000 is an allosteric, covalent and irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) (E1), with an IC50 of 0.2 μM for SUMOylation in vitro.
  • HY-B0610S
    Misoprostol-d5

    SC-29333-d5

    		 Prostaglandin Receptor Endocrinology
    Misoprostol-d5 is the deuterium labeled Misoprostol. Misoprostol (SC-29333) is an orally active synthetic prostaglandin E1 (PGE1) analog that is used for gastric ulcers research[1].
  • HY-103436
    NSC624206

    		E1/E2/E3 Enzyme Cancer
    NSC624206 is an inhibitor of ubiquitin E1 (UBA1), with an IC50 of ~9 μM. NSC624206 specifically blocks ubiquitin-thioester formation (IC50=13 μM) but has no effect on ubiquitin adenylation.
  • HY-116015
    Dihomo-γ-Linolenic acid methyl ester

    		Endogenous Metabolite Inflammation/Immunology
    Dihomo-γ-Linolenic acid is an n-6 polyunsaturated fatty acid that is mainly metabolized to an anti-inflammatory eicosanoid, prostaglandin (PG) E1, via the cyclooxygenase (COX) pathway. Anti-inflammatory and anti-proliferative effects.
  • HY-113293B
    Estrone sulfate sodium

    		Estrogen Receptor/ERR Endogenous Metabolite Cancer
    Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). strone sulfate can be used for the research of breast cancer.
  • HY-110273
    N106

    		Calcium Channel E1/E2/E3 Enzyme Cardiovascular Disease
    N106 is a first-in-class sarcoplasmic reticulum calcium ATPase (SERCA2a) SUMOylation activator. N106 directly activates the SUMO-activating enzyme, E1 ligase. N106 can be used for heart failure research.
  • HY-116463D
    (Rac)-E1R

    		Sigma Receptor Neurological Disease
    (Rac)-E1R (Compound 2) is the racemate of E1R. (Rac)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) used for the research of cognition/memory disorders.
  • HY-147652
    G-quadruplex DNA fluorescence probe 1

    		DNA Stain Others Others
    G-quadruplex DNA fluorescence probe 1 (Compound E1) is a selective G-quadruplex DNA targeting fluorescent probe. G-quadruplex DNA fluorescence probe 1 can pass through membrane and enter living cells with low cytotoxicity.
  • HY-113293BS
    Estrone sulfate-d5 sodium

    		Estrogen Receptor/ERR Endogenous Metabolite Cancer
    Estrone sulfate-d5 (sodium) is the deuterium labeled Estrone sulfate sodium. Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). strone sulfate can be used for the research of breast cancer[1][2].
  • HY-113293BS1
    Estrone sulfate-d4 sodium

    		Estrogen Receptor/ERR Endogenous Metabolite Cancer
    Estrone sulfate-d4 (sodium) is deuterium labeled Estrone sulfate (sodium). Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). strone sulfate can be used for the research of breast cancer[1][2].
  • HY-109045A
    Teslexivir hydrochloride

    BTA074 hydrochloride; AP 611074 hydrochloride

    		 E1/E2/E3 Enzyme HPV Infection
    Teslexivir (BTA074) hydrochloride is a potent antiviral agent. Teslexivir hydrochloride is a potent and selective inhibitor of the interaction between two essential viral proteins, E1 and E2, an association that is a necessary step in the DNA replication and thus viral production for Human Papilloma Virus (HPV) 6 and 11. Teslexivir hydrochloride can be used for condyloma research.
  • HY-109045
    Teslexivir

    BTA074; AP 611074

    		 E1/E2/E3 Enzyme HPV Infection
    Teslexivir (BTA074) is a potent antiviral agent. Teslexivir is a potent and selective inhibitor of the interaction between two essential viral proteins, E1 and E2, an association that is a necessary step in the DNA replication and thus viral production for Human Papilloma Virus (HPV) 6 and 11. Teslexivir can be used for condyloma research.
  • HY-116463B
    (2S,3S)-E1R

    		Sigma Receptor Neurological Disease
    (2S,3S)-E1R (Compound 2d) is an enantiomer of E1R. (2S,3S)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders.
  • HY-116463A
    (2R,3S)-E1R

    		Sigma Receptor Neurological Disease
    (2R,3S)-E1R (Compound 2c) is an enantiomer of E1R. (2R,3S)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders.
  • HY-116463C
    (2R,3R)-E1R

    		Sigma Receptor Neurological Disease
    (2R,3R)-E1R (Compound 2b) is an enantiomer of E1R. (2R,3R)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders.
  • HY-118189
    Misoprostol acid

    		Prostaglandin Receptor Inflammation/Immunology
    Misoprostol acid is an active metabolite of Misoprostol. Misoprostol is a synthetic analogue of prostaglandin E1 (PGE1), extensively absorbed, and undergoes rapid de-esterification to Misoprostol acid in the gastrointestinal tract after oral administration. Misoprostol can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers. Misoprostol is an oral agent used to induce labor.
  • HY-14427
    4E1RCat

    		Eukaryotic Initiation Factor (eIF) Autophagy Cancer
    4E1RCat is an inhibitor of cap-dependent translation, and inhibits eIF4E:eIF4GI interaction, with an IC50 an of ∼4 μM.
  • HY-17573A
    Carbetocin acetate

    		Oxytocin Receptor Endocrinology Neurological Disease
    Carbetocin acetate, an oxytocin (OT) analogue, is an oxytocin receptor agonist with a Ki of 7.1 nM. Carbetocin acetate has high affinity to chimeric N-terminus (E1) of the oxytocin receptor (Ki=1.17 μM). Carbetocin acetate has the potential for postpartum hemorrhage research. Carbetocin acetate can crosse the blood-brain barrier and produces antidepressant-like activity via activation of oxytocin receptors in the CNS.
  • HY-17573
    Carbetocin

    		Oxytocin Receptor Endocrinology Neurological Disease
    Carbetocin, an oxytocin (OT) analogue, is an oxytocin receptor agonist with a Ki of 7.1 nM. Carbetocin has high affinity to chimeric N-terminus (E1) of the oxytocin receptor (Ki=1.17 μM). Carbetocin has the potential for postpartum hemorrhage research. Carbetocin can crosse the blood-brain barrier and produces antidepressant-like activity via activation of oxytocin receptors in the CNS.
  • HY-118189S
    Misoprostol acid-d5

    		Prostaglandin Receptor Inflammation/Immunology
    Misoprostol acid-d5 is deuterium labeled Misoprostol acid. Misoprostol acid is an active metabolite of Misoprostol. Misoprostol is a synthetic analogue of prostaglandin E1 (PGE1), extensively absorbed, and undergoes rapid de-esterification to Misoprostol acid in the gastrointestinal tract after oral administration. Misoprostol can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers[1]. Misoprostol is an oral agent used to induce labor[2].
  • HY-W039947
    N6-[(2E)-1-Oxo-2-buten-1-yl]-L-lysine

    		Amino Acid Derivatives Others
    N6-[(2E)-1-Oxo-2-buten-1-yl]-L-lysine is a lysine derivative.
  • HY-17639
    Navamepent

    RX-10045

    		 Others Inflammation/Immunology
    Navamepent is an analog of naturally occurring resolvin E1 (a major dietary omega-3 polyunsaturated fatty-acid metabolite) with potent anti-inflammatory and cell survival benefits. Navamepent is highly effective against dry eye and goblet cell loss thereby accelerating tear production. Also, Navamepent can reduce corneal inflammation, epithelial damage, and accelerate corneal tissue repair. In addition, Navamepent can inhibit the release of several key proinflammatory mediators from corneal epithelial cells.
  • HY-N0997
    (6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one

    		NO Synthase Cancer Inflammation/Immunology
    (6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one (compound7) is a nature product isolated from rhizomes of Curcuma kwangsiensis. (6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one has inhibitory effect on NO production induced by LPS in macrophages with an IC50 value of 8.93 μM.
  • HY-19717
    DCVC

    S-[(1E)-1,2-dichloroethenyl]--L-cysteine

    		 TNF Receptor Inflammation/Immunology
    DCVC (S-[(1E)-1,2-dichloroethenyl]--L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and TNF-α release from tissue cultures.
  • HY-108648
    2-Methylthioadenosine diphosphate trisodium

    2-Methylthio-ADP trisodium

    		 P2Y Receptor Neurological Disease
    2-Methylthioadenosine diphosphate trisodium is a potent purinergic P2Y receptors agonist, with EC50s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium has pEC50s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-Methylthioadenosine diphosphate trisodium induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1.
  • HY-N1641
    1-O-Deacetylkhayanolide E

    Deacetylkhayanolide E

    		 Others Others
    1-O-Deacetylkhayanolide E is a khayanolide, which can be isolated from the stem bark of African mahogany Khaya senegalensis.
  • HY-100738
    Ubiquitin Isopeptidase Inhibitor I, G5

    NSC144303

    		 Apoptosis Cancer
    Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.
  • HY-136266
    HCV-IN-29

    		HCV Cancer
    HCV-IN-29 is a hepatitis C virus (HCV) inhibitor exacted from patent US8329159B2, compound 1e.
  • HY-13221
    BRL 54443

    		5-HT Receptor Cardiovascular Disease
    BRL 54443 is a potent 5-HT1E/1F receptor agonist (Ki values are 1.1 nM and 0.7 nM respectively); displays > 30-fold selectivity over other 5-HT and dopamine receptors.
  • HY-B1462S
    Chlorzoxazone-d3

    		Cytochrome P450 Inflammation/Immunology
    Chlorzoxazone-d3 is the deuterium labeled Chlorzoxazone. Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes.Chlorzoxazone is currently being used as a marker substrate in vitro/vivo studies to quantify cytochrome P450 2E1 (CYP2E1) activity in humans.
  • HY-10930
    UNC0321

    		Histone Methyltransferase Cancer
    UNC0321 is a potent and selective histone methyltransferase G9a inhibitor with a Ki of 63 pM and with assay-dependent IC50 values of 6-9 nM. UNC0321 also inhibits GLP with assay-dependent IC50 values of 15-23 nM. UNC0321 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E.
  • HY-N2586
    Tenuifoliside C

    		Others Inflammation/Immunology
    Tenuifoliside C, isolated from polygala tenuifolia willd, significantly inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1.
  • HY-152243
    YEATS4 binder-1

    		Others Others
    YEATS4 binder-1(4e) is a potent and selective YEATS4 binder that binds to the KAc recognition site of the YEATS structural domain with a Ki value of 37 nM.
  • HY-Y0110
    2-Naphthol

    		Endogenous Metabolite Others
    2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2).
  • HY-135572
    TLX agonist 1

    		Others Cancer Neurological Disease
    TLX agonist 1 (ccrp2) is an orphan nuclear receptor tailless (TLX, NR2E1) modulator (EC50=1μM; Kd= 650 nM). TLX agonist 1 potentiates TLX transcriptional repressive activity.
  • HY-N1407
    Polygalaxanthone III

    		Cytochrome P450 Inflammation/Immunology
    Polygalaxanthone III is extracted from polygala tenuifolia wild, has inhibitory effect towards CYP450 enzyme. Polygalaxanthone III inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1 with an IC50 of 50.56 μM.
  • HY-129105
    Clomethiazole

    		GABA Receptor Cytochrome P450 Neurological Disease
    Chlormethiazole is an potent and orally active GABAA agonist. Chlormethiazole inhibits cytochrome P450 isoforms: CYP2A6 and CYP2E1 in human liver microsomes. Chlormethiazole is an anticonvulsant agent and has the potential for treating convulsive status epilepticus.
  • HY-W009247S
    N-Desmethyl Olanzapine-d8

    		Isotope-Labeled Compounds Others
    N-Desmethyl Olanzapine-d8 is deuterium labeled 2-Methyl-4-(piperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepine.
  • HY-19435A
    GYKI-47261 dihydrochloride

    		iGluR Cytochrome P450 Neurological Disease
    GYKI-47261 dihydrochloride is a competitive, orally active, and selective AMPA receptor antagonist with an IC50 of 2.5 μM. GYKI-47261 has broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-47261 dihydrochloride is also a potent inducer of CYP2E1.
  • HY-B0876
    Fomepizole

    4-Methylpyrazole

    		 Cytochrome P450 Metabolic Disease
    Fomepizole (4-Methylpyrazole) is a potent cytochrome P450 (CYP2E1) inhibitor. Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole has the potential for an antidote for ethylene glycol or methanol poisoning.
  • HY-146177
    CYP3A4 enzyme-IN-1

    		Bacterial Cytochrome P450 Infection
    CYP3A4 enzyme-IN-1 (compound 59) is a potent antibacterial agent, with a MIC of 1 μg/mL for MRSA. CYP3A4 enzyme-IN-1 exhibits low to moderate inhibitory effects on CYP1A2, CYP2E1, CYP2D6, and CYP3A4 enzymes.
  • HY-B0876A
    Fomepizole hydrochloride

    4-Methylpyrazole hydrochloride

    		 Cytochrome P450 Metabolic Disease
    Fomepizole (4-Methylpyrazole) hydrochloride is a potent and orally active cytochrome P450 (CYP2E1) inhibitor. Fomepizole hydrochloride is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole hydrochloride blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole hydrochloride has the potential for an antidote for ethylene glycol or methanol poisoning.
  • HY-N4110
    Friedelin

    		Cytochrome P450 Metabolic Disease
    Friedelin is isolated from isolated from the leaves of Maytenus ilicifolia(Mart). Friedelin is a noncompetitive inhibitor of CYP3A4 with IC50 and Kivalues of 10.79  μM and 6.16  μM, respectively. Friedelin is also a competitive inhibitor of CYP2E1 with IC50 and Ki values of 22.54  μM and 18.02 μM, respectively.
  • HY-B0717
    Tocofersolan

    TPGS; D-α-Tocopherol polyethylene glycol 1000 succinate; Vitamin E-TPGS

    		 Others Metabolic Disease Neurological Disease
    Tocofersolan is synthetic polyethylene glycol derivative of α-tocopherol. Tocofersolan is an orally active and water-soluble analog of vitamin E. Tocofersolan can reduce neurobehavioral deficits in zebrafish embryos exposed to moderate and high concentrations of BaP during early development. Tocofersolan shows antioxidant activity. Tocofersolan can be used to provide an orally bioavailable source of vitamin E.
  • HY-10929
    UNC0224

    		Histone Methyltransferase Cancer
    UNC0224 is a potent and selective histone methyltransferase G9a inhibitor with a Ki of 2.6 nM, an IC50 of 15 nM and a Kd of 23 nM. UNC0224 also potently inhibits b>GLP with assay-dependent IC50 values of 20-58 nM. UNC0224 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E.
  • HY-Y0698
    Thioacetamide

    Acetothioamide; TAA; Thiacetamide

    		 Necroptosis Inflammation/Immunology
    Thioacetamide (TAA) is an indirect hepatotoxin and causes parenchymal cell necrosis. Thioacetamide requires metabolic activation by microsomal CYP2E1 to thioacetamide-S-oxide initially and then to thioacetamide-S-dioxide, which is a highly reactive metabolite, and its reactive metabolites covalently bind to proteins and lipids thereby causing oxidative stress and centrilobular necrosis. Thioacetamide can induce chronic liver fibrosis, encephalopathy and other events model.
  • HY-117026
    LKY-047

    		Cytochrome P450 Metabolic Disease Inflammation/Immunology
    LKY-047, a Decursin derivative, is a potent and selective reversible competitive cytochrome P45022J2 (CYP2J2) inhibitor with an IC50 of 1.7 μM. LKY-047 is inactive against other human P450s, such as CYPs 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, and 3A.
  • HY-124322
    NB-360

    		Beta-secretase Inflammation/Immunology Neurological Disease
    NB-360 is a potent, brain penetrable, and orally bioavailable dual BACE1/BACE2 inhibitor (IC50: mouse and human BACE1=5 nM; BACE2=6 nM). NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice. NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E.
  • HY-150612
    (R)-STU104

    		p38 MAPK Cancer
    (R)-STU104 is a potent and orally active TAK1-MKK3 interaction inhibitor with IC50s of 0.58 μM and 4.0 μM for TNF-α and MKK3 phosphorylation. (R)-STU104 suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signal pathways through binding with MKK3 and disrupting the TAK1 phosphorylating MKK3. (R)-STU104 can be used for researching ulcerative colitis.