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Results for "E3 ligase Ligand-Linker Conjugates 32" in MCE Product Catalog:

Cat. No. Product Name Target Research Areas
  • HY-126458
    Thalidomide-O-PEG2-propargyl

    E3 ligase Ligand-Linker Conjugates 32

    E3 Ligase Ligand-Linker Conjugate Cancer
    Thalidomide-O-PEG2-propargyl (E3 ligase Ligand-Linker Conjugates 32) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.
  • HY-115446A
    Lenalidomide-C4-NH2 hydrochloride

    Cereblon Ligand 1 hydrochloride; E3 ligase Ligand-Linker Conjugates 32 hydrochloride

    E3 Ligase Ligand-Linker Conjugate Cancer
    Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively.