Search Result

Results for "

E3-ligase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	E1/E2/E3 Enzyme (8) E3 Ligase Ligand-Linker Conjugates (306) Ligands for E3 Ligase (162) ADC Linker (1) Androgen Receptor (4) APC (1) Apoptosis (16) Aryl Hydrocarbon Receptor (1) Autophagy (79) Bcl-2 Family (3) BCL6 (1) Bcr-Abl (2) Btk (3) c-Myc (1) CDK (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (1) Drug-Linker Conjugates for ADC (1) EGFR (1) Endogenous Metabolite (1) Epigenetic Reader Domain (4) Estrogen Receptor/ERR (4) FAK (2) FKBP (2) GLP Receptor (1) GSK-3 (1) HDAC (6) HIF/HIF Prolyl-Hydroxylase (2) Histone Methyltransferase (4) Indoleamine 2,3-Dioxygenase (IDO) (1) Isotope-Labeled Compounds (3) Ligands for Target Protein for PROTAC (6) MEK (1) Molecular Glues (20) NF-κB (2) PERK (1) PROTAC Linkers (1) PROTACs (46) Ras (2) STING (1) Target Protein Ligand-Linker Conjugates (9) Tau Protein (1) α-synuclein (1) β-catenin (5)
By Research Areas:	Cancer (518) Inflammation/Immunology (20) Metabolic Disease (1) Neurological Disease (3)
Click Chemistry:	Azide (30) Alkynes (3)

547

Inhibitors & Agonists

Screening Libraries

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

*E3 ligase* Ligand 18**	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 18 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 18 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .

*E3 ligase* Ligand 8** 3 Publications Verification	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 8 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .

*E3 Ligase* Ligand-Linker Conjugate Kit**	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-Linker Conjugate Kit is a series of synthesized compounds that incorporate an E3 ligase ligand and a linker used in PROTAC technology.

*E3 ligase* Ligand 10**	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 10 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 10 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .

*E3 ligase* Ligand 14**	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 14 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 14 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .

*E3 ligase* Ligand 13**	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 13 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 13 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .

*E3 Ligase* Ligand-linker Conjugate 77**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 77 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 77 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 ligase* Ligand-Linker Conjugate 29**	Ligands for E3 Ligase Autophagy	Cancer
E3 ligase Ligand-Linker Conjugate 29 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase* Ligand-Linker Conjugate 29 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 ligase* Ligand-Linker Conjugate 37**	Ligands for E3 Ligase Autophagy	Cancer
E3 ligase Ligand-Linker Conjugate 37 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase* Ligand-Linker Conjugate 37 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 ligase* Ligand-Linker Conjugate 38**	Ligands for E3 Ligase Autophagy	Cancer
E3 ligase Ligand-Linker Conjugate 38 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase* Ligand-Linker Conjugate 38 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 ligase* Ligand-Linker Conjugate 65**	Ligands for E3 Ligase Autophagy	Cancer
E3 ligase Ligand-Linker Conjugate 65 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase* Ligand-Linker Conjugate 65 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 ligase* Ligand-Linker Conjugate 66**	Ligands for E3 Ligase Autophagy	Cancer
E3 ligase Ligand-Linker Conjugate 66 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase* Ligand-Linker Conjugate 66 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 92**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 92 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 92 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 93**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 93 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 93 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 94**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 94 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 94 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 99**	Ligands for E3 Ligase Autophagy E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 99 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 99 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 100**	Ligands for E3 Ligase Autophagy E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 100 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 100 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 104**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 104 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 104 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 105**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 105 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 105 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 106**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 106 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 106 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 1**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 1 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 1 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 2**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 2 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 2 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 5**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 5 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 5 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 7**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 7 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 7 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 9**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 9 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 9 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 ligase* Ligand-Linker Conjugate 11**	Ligands for E3 Ligase Autophagy	Cancer
E3 ligase Ligand-Linker Conjugate 11 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase* Ligand-Linker Conjugate 11 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 12**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 12 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 12 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 13**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 13 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 13 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 14**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 14 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 14 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 16**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 16 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 16 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 17**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 17 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 17 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 18**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 18 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 18 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 20**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 20 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 20 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 28**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 28 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 28 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 ligase* Ligand-Linker Conjugate 34**	Ligands for E3 Ligase Autophagy	Cancer
E3 ligase Ligand-Linker Conjugate 34 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase* Ligand-Linker Conjugate 34 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 ligase* Ligand-Linker Conjugate 39**	Ligands for E3 Ligase Autophagy	Cancer
E3 ligase Ligand-Linker Conjugate 39 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase* Ligand-Linker Conjugate 39 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 ligase* Ligand-Linker Conjugate 41**	Ligands for E3 Ligase Autophagy	Cancer
E3 ligase Ligand-Linker Conjugate 41 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase* Ligand-Linker Conjugate 41 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 ligase* Ligand-Linker Conjugate 43**	Ligands for E3 Ligase Autophagy	Cancer
E3 ligase Ligand-Linker Conjugate 43 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase* Ligand-Linker Conjugate 43 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 45**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 45 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 45 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 47**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 47 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 47 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 51**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 51 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 51 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 54**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 54 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 54 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 55**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 55 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 55 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 Ligase* Ligand-linker Conjugate 58**	Ligands for E3 Ligase Autophagy	Cancer
E3 Ligase Ligand-linker Conjugate 58 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 58 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

*E3 ligase* Ligand 9**	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .

*E3 ligase* Ligand-Linker Conjugate 32**	Ligands for E3 Ligase	Cancer
E3 ligase Ligand-Linker Conjugate 32 is a *conjugate of E3 ligase* ligand and linker*, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. E3 ligase* Ligand-Linker Conjugate 32 can be used as a key intermediate for the synthesis of complete PROTAC molecules.

Cat. No.	Product Name

HY-L128

E3 Ligase Ligand Library

88 compounds

Although there are more than 600 E3 ubiquitin ligases, only several with small molecule ligands have been used for designing PROTACs, including Skp1-Cullin-F box complex containing Hrt1 (SCF), Von Hippel-Lindau tumor suppressor (VHL), Cereblon (CRBN), inhibitor of apoptosis proteins (IAPs), and mouse double minute 2 homolog (MDM2).

MCE carefully prepared a unique collection of 88 ligands for E3 ligase, which have been reported to be used in PROTAC design. MCE E3 ligase ligand library is a useful tool for PROTAC development.

HY-L129

Target Protein Ligand Library

39 compounds

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation. Therefore, PROTACs execute their functions by degrading the target proteins rather than inhibiting them, which has a great superiority in overcoming resistance caused by target mutation or overexpression. To date, PROTAC technology has been applied to a variety of targets, including AR, ER, BTK, BET, and BCR-ABL to overcome resistance.

MCE carefully prepared a unique collection of 39 ligands for target proteins, which have been reported to be used in PROTAC design. MCE Target Protein Ligand Library is a useful tool for PROTAC development.

HY-L137

Molecular Glue Compound Library

35 Compounds compounds

Targeted protein degradation(TPD) is a novel and promising approach to new drug discovery and development. It shows great potential for treating diseases with “undruggable” pathogenic protein targets and for overcoming drug resistance. Molecular glues and PROTACs are both targeted protein degraders that have attracted the most attention.

Molecular glues are small molecular degraders that mainly induce novel interaction between an E3 ligase and a target protein to form a ternary complex, leading to protein ubiquitination and subsequent proteasome degradation. Compared with PROTACs, molecular glues generally possess more favorable drug-like properties, such as lower MW, higher cell permeability, and better oral absorption. Molecular glues are emerging as a promising new therapeutic strategy.

MCE supplies a unique collection of 35 molecular glues which target various proteins. MCE Molecular Glue Compound Library is a useful tool to conduct scientific research and disease mechanism study.

Cat. No.	Product Name		Classification

HY-126458

Thalidomide-O-PEG2-propargyl E3 ligase Ligand-Linker Conjugates 32		Alkynes
Thalidomide-O-PEG2-propargyl (E3 ligase Ligand-Linker Conjugates 32) is a synthesized *E3 ligase* ligand-linker conjugate** that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology . Thalidomide-O-PEG2-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-103615

Thalidomide-O-amido-C4-N3 1 Publications Verification Cereblon Ligand-Linker Conjugates 4; E3 ligase Ligand-Linker Conjugates 18		Azide
Thalidomide-O-amido-C4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-amido-C4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-103598

(S,R,S)-AHPC-PEG3-N3 VH032-PEG3-N3; VHL Ligand-Linker Conjugates 8; E3 ligase Ligand-Linker Conjugates 12		Azide
(S,R,S)-AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-103599

(S,R,S)-AHPC-PEG2-N3 VH032-PEG2-N3; VHL Ligand-Linker Conjugates 6; E3 ligase Ligand-Linker Conjugates 13		Azide
(S,R,S)-AHPC-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-103600

(S,R,S)-AHPC-PEG1-N3 VH032-PEG1-N3; VHL Ligand-Linker Conjugates 9; E3 ligase Ligand-Linker Conjugates 3		Azide
(S,R,S)-AHPC-PEG1-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG1-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-103601

(S,R,S)-AHPC-PEG4-N3 VH032-PEG4-N3; VHL Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 4		Azide
(S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-128832

Nutlin-C1-amido-PEG4-C2-N3 MDM2 Ligand-Linker Conjugates 1; E3 ligase Ligand-Linker Conjugates 48		Azide
Nutlin-C1-amido-PEG4-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Nutlin 3 based MDM2 ligand and 4-unit PEG linker used in PROTAC technology. Nutlin-C1-amido-PEG4-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-125843

Pomalidomide-PEG1-C2-N3 Cereblon Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 50		Azide
Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC₅₀ of 2.1 nM . Pomalidomide-PEG1-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-148556

Thalidomide-O-C6-azide		Azide
Thalidomide-O-C6-azide is a synthesized *E3 ligase* ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugates) that incorporates the Thalidomide (Thalidomide (HY-14658)**) based cereblon ligand and a linker used in PROTAC technology . Thalidomide-O-C6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-160077

Pomalidomide-CO-C5-azide		Azide
Pomalidomide-CO-C5-azide (Compound PA) is a ligand for E3 ligase bearing a bioorthogonal group azide. Pomalidomide-CO-C5-azide can be used to synthesize PROTACs with anticancer activity .

HY-139332

Pomalidomide 4'-PEG6-azide		Azide
Pomalidomide 4'-PEG6-azide (compound 33e) is the *E3 ligase* ligand-linker conjugate** used in the recruitment of CRBN protein. Pomalidomide 4'-alkylC3-acid can be used to synthesize PROTACs .

HY-163167

VH 032 amide-alkylC5-azide		Azide
VH 032 amide-alkylC5-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand .

HY-139343

Pomalidomide 4'-alkylC2-azide		Azide
Pomalidomide 4'-alkylC2-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC2-azide can be used in the synthesis of PROTAC .

HY-139341

Pomalidomide 4'-alkylC3-azide		Azide
Pomalidomide 4'-alkylC3-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC3-azide can be used in the synthesis of PROTAC .

HY-140055

Thalidomide-PEG4-Propargyl		Alkynes
Thalidomide-PEG4-Propargyl is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology . Thalidomide-PEG4-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-128767

VH032-PEG3-acetylene		Alkynes
VH032-PEG3-acetylene is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology . VH032-PEG3-acetylene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-141015

Pomalidomide-PEG4-azide		Azide
Pomalidomide-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology . Pomalidomide-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-140844

Thalidomide-O-PEG4-azide		Azide
Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-137537

Pomalidomide-PEG2-azide		Azide
Pomalidomide-PEG2-azide is a synthesized *E3 ligase* ligand-linker conjugate** that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology . Pomalidomide-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-137538

Pomalidomide-PEG3-azide		Azide
Pomalidomide-PEG3-azide is a synthesized *E3 ligase* ligand-linker conjugate** that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology . Pomalidomide-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-132208

Pomalidomide 4'-PEG2-azide		Azide
Pomalidomide 4'-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology . Pomalidomide 4'-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-157510

Thalidomide-O-C3-azide		Azide
Thalidomide-O-C3-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C3-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C3-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-157511

Thalidomide-O-C5-azide		Azide
Thalidomide-O-C5-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C5-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C5-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-139999

LCL-PEG3-N3		Azide
LCL-PEG3-N3 is a decoy oligonucleotide ligand for E3 ligase which can be used for developing chimeric molecules LCL-ER(dec), degrading the estrogen receptor . LCL-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-139999A

LCL-PEG3-N3 hydrochloride		Azide
LCL-PEG3-N3 (hydrochloride) is a decoy oligonucleotide ligand for E3 ligase which can be used for developing chimeric molecules LCL-ER(dec), degrading the estrogen receptor . LCL-PEG3-N3 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-157515

Thalidomide 4'-ether-PEG2-azide		Azide
Thalidomide 4'-ether-PEG2-azide is a click chemistry modified cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide 4'-ether-PEG2-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkynyl groups. Thalidomide 4'-ether-PEG2-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-151792

Pomalidomid-C6-PEG3-butyl-N3		Azide
Pomalidomid-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. Pomalidomid-C6-PEG3-butyl-N3 also is a crosslinker-E3 ligase ligand conjugate, which be used in click reactive protein degrader building block for PROTAC research. Pomalidomid-C6-PEG3-butyl-N3 also can be used in the template for synthesis of targeted protein degrader .

HY-161131

Lenalidomide 4'-alkyl-C3-azide		Azide
Lenalidomide 4'-alkyl-C3-azide (compound 4a) is a click chemical modified Lenalidomide (HY-A0003) that can be used to synthesize PROTACs. Lenalidomide is an orally active immunomodulator and a ligand for the ubiquitin E3 ligase cereblon (CRBN). Lenalidomide 4'-alkyl-C3-azide contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition reactions (SPAAC) can also occur with molecules containing DBCO or BCN groups .

HY-133138

Pomalidomide-PEG1-azide		Azide
Pomalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Pomalidomide-PEG1-azide incorporates the Pomalidomide based cereblon ligand and a linker.?Pomalidomide-PEG1-azide?can be used to design a?PROTAC BRD4 Degrader-1 (HY-133131) . Pomalidomide-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-133139

Lenalidomide-PEG1-azide		Azide
Lenalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Lenalidomide-PEG1-azide incorporates the Lenalidomide based cereblon ligand and a linker.?Lenalidomide-PEG1-azide?can be used to design a PROTAC BRD4 Degrader-2 (HY-133136) . Lenalidomide-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-130652

Pomalidomide 4'-PEG3-azide		Azide
Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4'-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient PARP1?degrader based on Rucaparib by using the PROTAC approach . Pomalidomide 4'-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-151791

(S,R,S)-AHPC-C6-PEG3-butyl-N3		Azide
(S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. (S,R,S)-AHPC-C6-PEG3-butyl-N3 serves as crosslinker-E3 ligase ligand conjugate, Click reactive protein degrader building block for PROTAC research, Template for synthesis of targeted protein degrader, VH032 conjugate . (S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-130654

(S,R,S)-AHPC-C2-PEG4-N3 VH032-C2-PEG4-N3		Azide
(S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthesized *E3 ligase* ligand-linker conjugate** that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-C2-PEG4-N3 can be used in the synthesis of vRucaparib-TP4 (HY-130647). vRucaparib-TP4 a highly potent PARP1 degrader with a half-maximal degrading concentration (DC₅₀) of 82 nM . (S,R,S)-AHPC-C2-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks