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Results for "

EBOV

" in MCE Product Catalog:

By Targets:	5-HT Receptor (2) Antibiotic (1) Apoptosis (5) Autophagy (4) Cathepsin (1) CCR (1) Cytochrome P450 (1) EBV (1) Estrogen Receptor/ERR (7) Filovirus (9) Glucosidase (1) HCV (2) Histamine Receptor (1) HIV (2) HSP (3) Influenza Virus (4) Parasite (1) PKC (2) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (10) Infection (21) Inflammation/Immunology (2)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas

HY-137498

EBOV/MARV-IN-1	Filovirus	Infection
EBOV/MARV-IN-1 is a potent inhibitor of Ebola virus (EBOV) and Marburg virus (MARV), with broad-spectrum activity (EC₅₀=0.31, and 0.82 µM, respectively) and low cytotoxicity (SI>100) in HeLa cells.

HY-146814

EBOV/MARV-IN-3	Filovirus	Infection
EBOV/MARV-IN-3 (compound 32) is a potent *EBOV* and MARV inhibitor with IC₅₀ values of 0.5, 1.2 µM, respectively. EBOV/MARV-IN-3 binds to the hydrophobic pocket close to EBOV Y517. EBOV/MARV-IN-3 shows antiviral activity.

HY-150756

EBOV-GP-IN-1
Filovirus Infection

EBOV-GP-IN-1 (Compound 28) is a potent Ebola entry inhibitor with an IC₅₀ of 0.05 μM against Ebola virus envelope glycoprotein (EBOV-GP).
HY-146813

EBOV/MARV-IN-2
Others Infection

EBOV/MARV-IN-2 (compound 13) is an Ebolavirus (EBOV, IC₅₀=0.9 μM) and Marburg virus (MARV, IC₅₀=2.7 μM) inhibitor.

EBOV-GP-IN-1	Filovirus	Infection
EBOV-GP-IN-1 (Compound 28) is a potent Ebola entry inhibitor with an IC₅₀ of 0.05 μM against Ebola virus envelope glycoprotein (EBOV-GP).

EBOV/MARV-IN-2	Others	Infection
EBOV/MARV-IN-2 (compound 13) is an Ebolavirus (EBOV, IC₅₀=0.9 μM) and Marburg virus (MARV, IC₅₀=2.7 μM) inhibitor.

HY-131233

Anti-virus agent 1 Remdesivir isopropyl ester analog	Antibiotic	Infection
Anti-virus agent 1 (compound 4i), a phosphoramidate proagent of GS-5734 (HY-104077; Remdesivir), has potent antiviral activity. Anti-virus agent 1 is used for the research of coronavirus and Ebola virus (EBOV).

HY-146815

CP19	Histamine Receptor Filovirus	Infection
CP19, a histamine receptor antagonist, is an entry inhibitor against both Ebolavirus (EBOV) and Marburgvirus (MARV) with IC₅₀s of 3.4 μM and 29.5 μM, respectively. CP19 has SI values of 29.4 and 3.4 for EBOV and MARV, respectively. CP19 has antiviral activity.

HY-124662

IHVR-19029	Glucosidase	Infection
IHVR-19029 is a potent endoplasmic reticulum (ER) α-glucosidases I and II inhibitor, with an IC₅₀ of 0.48 μM for ER a-glucosidase I. IHVR-19029 efficiently blocks the replication of several hemorrhagic fever viruses, such as Dengue virus (DENV), Ebola virus (EBOV) and Rift Valley fever virus. The combination of IHVR-19029 with Favipiravir (HY-14768) improves the antiviral efficacy.

HY-P99343

Atoltivimab REGN3470	Filovirus	Infection
Atoltivimab (REGN3470), or maftivimab/odesivimab (Inmazeb) is the first Food and agent Administration (FDA)-approved monoclonal antibody to target Zaire ebolavirus (EBOVs) infection.

HY-N4118

Cephaeline (-)-Cephaeline; NSC 32944 free base	Influenza Virus Filovirus	Infection
Cephaeline is a phenolic alkaloid in Indian Ipecac roots. Cephaeline exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections.

HY-N2076

Cephaeline hydrochloride (-)-Cephaeline hydrochloride; NSC 32944 monohydrochloride	Influenza Virus Filovirus	Infection
Cephaeline hydrochloride ((-)-Cephaeline hydrochloride) is a phenolic alkaloid in Indian Ipecac roots. Cephaeline hydrochloride exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections.

HY-P99832

Cosfroviximab
c13C6-FR1
Filovirus Infection

Cosfroviximab (c13C6-FR1) is a mouse/human chimeric monoclonal antibody against Ebola virus glycoprotein (EBOV-GP).

Cosfroviximab c13C6-FR1	Filovirus	Infection
Cosfroviximab (c13C6-FR1) is a mouse/human chimeric monoclonal antibody against Ebola virus glycoprotein (EBOV-GP).

HY-B0005A

Toremifene Z-Toremifene; NK 622 free base; FC-1157a free base	Estrogen Receptor/ERR	Cancer Infection
Toremifene (Z-Toremifene) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.07 µM and 2.6 µM, respectively.

HY-B0005

Toremifene citrate Z-Toremifene citrate; NK 622; FC-1157a	Estrogen Receptor/ERR Apoptosis	Cancer Infection
Toremifene citrate (Z-Toremifene citrate) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.07 µM and 2.6 µM, respectively.

HY-122571

Retro-2	Filovirus Parasite Autophagy	Cancer Infection
Retro-2 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an *ebolavirus (EBOV) infection* inhibitor with an EC₅₀ of 12.2 µM in HeLa cells. Retro-2 induces cell autophagy.

HY-105070

Eritoran	EBV Toll-like Receptor (TLR)	Infection
Eritoran is a Toll-like receptor 4 (TLR4) antagonist. Eritoran protects mice against lethal influenza virus infection, such as Ebola virus (EBOV), Marburg virus (MARV). Eritoran decreases the level of granulocytosis, may alleviate the severity of the "cytokine storm". Eritoran inhibits pathogenesis of filovirus infection.

HY-B0005AS

Toremifene-d6 Z-Toremifene-d₆; NK 622-d6 (free base); FC-1157a-d6 (free base)	Estrogen Receptor/ERR	Cancer Infection
Toremifene-d₆ is deuterium labeled Toremifene. Toremifene (Z-Toremifene) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively[1][2].

HY-B0005S

Toremifene-d6 citrate	Estrogen Receptor/ERR Apoptosis	Cancer Infection
Toremifene-d₆ (citrate) is the deuterium labeled Toremifene citrate. Toremifene citrate (Z-Toremifene citrate) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively[1][2].

HY-107613A

R 59-022 hydrochloride DKGI-I hydrochloride; Diacylglycerol kinase inhibitor I hydrochloride	PKC 5-HT Receptor	Cancer Infection Inflammation/Immunology
R 59-022 (DKGI-I) hydrochloride is a DGK inhibitor (IC₅₀: 2.8 µM). R 59-022 hydrochloride inhibits the phosphorylation of OAG to OAPA. R 59-022 hydrochloride is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 hydrochloride potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils.

HY-107613

R 59-022 DKGI-I; Diacylglycerol kinase inhibitor I	PKC 5-HT Receptor	Inflammation/Immunology
R 59-022 (DKGI-I) is a DGK inhibitor (IC₅₀: 2.8 µM). R 59-022 inhibits the phosphorylation of OAG to OAPA. R 59-022 is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils.

HY-124618

FGI-106	Influenza Virus HCV HIV	Infection
FGI-106 is a potent and broad-spectrum inhibitor with inhibitory activity against multiple viruses. FGI-106 is active against Ebola, Rift Valley and Dengue Fever viruses with EC₅₀s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC₅₀s of 200 nM and 150 nM, respectively.

HY-124618A

FGI-106 tetrahydrochloride	Influenza Virus HCV HIV	Infection
FGI-106 tetrahydrochloride is a potent and broad-spectrum inhibitor with inhibitory activity against multiple viruses. FGI-106 tetrahydrochloride is active against Ebola, Rift Valley and Dengue Fever viruses with EC₅₀s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 tetrahydrochloride also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC₅₀s of 200 nM and 150 nM, respectively.

HY-119293

K777	Cathepsin CCR Cytochrome P450	Cancer Infection
K777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC₅₀ of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 inhibits SARS-CoV and *EBOV* pseudovirus entry with IC₅₀ values of 0.68 nM and 0.87 nM, respectively.

HY-13757A

Tamoxifen ICI 47699; (Z)-Tamoxifen; trans-Tamoxifen	Estrogen Receptor/ERR HSP Autophagy Apoptosis	Cancer
Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 µM and 1.8 µM, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse.

HY-13757

Tamoxifen Citrate ICI 46474; (Z)-Tamoxifen Citrate; trans-Tamoxifen Citrate	Estrogen Receptor/ERR HSP Autophagy Apoptosis	Cancer
Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells.Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 µM and 1.8 µM, respectively. Tamoxifen Citrate activates autophagy and induces apoptosis.Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse.

HY-13757AS1

Tamoxifen-d3 ICI 47699-d₃; (Z)-Tamoxifen-d₃; trans-Tamoxifen-d₃	Estrogen Receptor/ERR Apoptosis Autophagy HSP	Cancer
Tamoxifen-d₃ is the deuterium labeled Tamoxifen[1]. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[2][3][4]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively[6]. Tamoxifen activates autophagy and induces apoptosis[5]. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse[7].

Cat. No.	Product Name	Target	Research Area

HY-P99343

Atoltivimab REGN3470	Filovirus	Infection
Atoltivimab (REGN3470), or maftivimab/odesivimab (Inmazeb) is the first Food and agent Administration (FDA)-approved monoclonal antibody to target Zaire ebolavirus (EBOVs) infection.

HY-P99832

Cosfroviximab
c13C6-FR1
Filovirus Infection

Cosfroviximab (c13C6-FR1) is a mouse/human chimeric monoclonal antibody against Ebola virus glycoprotein (EBOV-GP).

Cosfroviximab c13C6-FR1	Filovirus	Infection
Cosfroviximab (c13C6-FR1) is a mouse/human chimeric monoclonal antibody against Ebola virus glycoprotein (EBOV-GP).

Cat. No.	Product Name	Target	Category

HY-N4118

Cephaeline (-)-Cephaeline; NSC 32944 free base	Influenza Virus Filovirus	Alkaloids Isoquinoline Alkaloids Phenols Monophenols Classification of Application Fields Disease Research Fields Infection Source classification Plants other families
Cephaeline is a phenolic alkaloid in Indian Ipecac roots. Cephaeline exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections.

HY-N2076

Cephaeline hydrochloride (-)-Cephaeline hydrochloride; NSC 32944 monohydrochloride	Influenza Virus Filovirus	Alkaloids Isoquinoline Alkaloids Phenols Monophenols Classification of Application Fields Disease Research Fields Infection Source classification Plants other families
Cephaeline hydrochloride ((-)-Cephaeline hydrochloride) is a phenolic alkaloid in Indian Ipecac roots. Cephaeline hydrochloride exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections.

Species:	Virus (32)
Tag:	His (26) Tag Free (1) MBP (2) Fc (5)
Source:	HEK293 (15) Sf9 insect cells (7) E. coli (10)

Cat. No.	Product Name	Species	Source

HY-P76310

Ebola virus VP24 Protein (AHX24653, His)
Ebola virus EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) VP24 Protein; VP24 Protein; EBOV
Virus E. coli
HY-P76309

Ebola virus VP24 Protein (YP_003815439, His)
Ebola virus EBOV (subtype Bundibugyo, strain Uganda 2007) VP24 Protein; VP24 Protein; EBOV
Virus E. coli

HY-P75272

Ebola virus Glycoprotein/GP Protein (AIE11917, HEK293, His) Ebola virus EBOV (subtype Zaire, strain Ebola virus H.sapiens-wt/SLE/2014/ManoRiver-G3686.1) Glycoprotein / EBOV-G Protein (His)	Virus	HEK293

HY-P75271

Ebola virus Glycoprotein/GP Protein (Q05320, sf9, His)
Ebola virus EBOV (subtype Zaire, strain Mayinga 1976) Glycoprotein / GP Protein (His)
Virus Sf9 insect cells
HY-P76893

Ebola virus Glycoprotein/GP Protein RBD (AAC54887, HEK293)
Ebola virus EBOV (subtype Zaire, strain Mayinga 1976) GP-RBD / Glycoprotein Protein
Virus HEK293
HY-P75269

Ebola virus Glycoprotein/GP Protein (Q7T9D9, HEK293, His)
Ebola virus EBOV (subtype Sudan, strain Gulu) GP / Glycoprotein Protein
Virus HEK293
HY-P75715

Ebola virus Glycoprotein/GP1 Protein (ACI28624, sf9, His)
Ebola virus EBOV (subtype Bundibugyo, strain Uganda 2007) GP1 / Glycoprotein Protein (His)
Virus Sf9 insect cells
HY-P75722

Ebola virus NP/Nucleoprotein Protein (His)
Ebola virus EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Nucleoprotein / NP Protein (His)
Virus E. coli
HY-P75725

Ebola virus NP/Nucleoprotein Protein (109a.a, Q5XX08, His)
Ebola virus EBOV (Sudan ebolAvirus, strain Gulu) Nucleoprotein / NP Protein (His)
Virus E. coli
HY-P76882

Ebola virus Glycoprotein/GP Protein RBD (ACI28624, HEK293, Fc)
Ebola virus EBOV (subtype Bundibugyo, strain Uganda 2007) Glycoprotein / GP-RBD Protein (Fc)
Virus HEK293
HY-P76892

Ebola virus Glycoprotein/GP Protein RBD (Q05320, HEK293, Fc)
Ebola virus EBOV (subtype Zaire, strain Mayinga 1976) Glycoprotein / GP-RBD Protein (Fc)
Virus HEK293
HY-P76894

Ebola virus Glycoprotein/GP Protein RBD (Q05320, HEK293, His)
Ebola virus EBOV (subtype Zaire, strain Mayinga 1976) GP-RBD / Glycoprotein Protein (His)
Virus HEK293
HY-P75270

Ebola virus Glycoprotein/GP Protein (Q7T9D9, sf9, His)
Ebola virus EBOV (Subtype Sudan, strain Gulu) Glycoprotein / GP Protein (His)
Virus Sf9 insect cells
HY-P76886

Ebola virus Glycoprotein/GP Protein RBD (Q7T9D9, HEK293, Fc)
Ebola virus EBOV (subtype Sudan, strain Gulu) GP-RBD / Glycoprotein Protein (Fc)
Virus HEK293
HY-P75268

Ebola virus Glycoprotein/GP Protein (QDA39862, HEK293, His)
Ebola virus EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Makona-Kissidougou-C15) GP / Glycoprotein Protein
Virus HEK293
HY-P75273

Ebola virus Glycoprotein/GP Protein (AHX24649, sf9, His)
Ebola virus EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Glycoprotein / GP Protein (His)
Virus Sf9 insect cells
HY-P75719

Ebola virus VP40/Matrix VP40 Protein (YP_138522, His-MBP)
Ebola virus EBOV (subtype Sudan, strain Gulu) VP40 / Matrix protein VP40 Protein (His-MBP)
Virus E. coli
HY-P75720

Ebola virus VP40/Matrix VP40 Protein (Q5XX06, His)
Ebola virus EBOV (subtype Sudan, strain Gulu) VP40 / Matrix protein VP40 Protein (His)
Virus E. coli
HY-P75724

Ebola virus NP/Nucleoprotein Protein (378a.a, Q5XX08, His)
Ebola virus EBOV (Sudan ebolAvirus, strain Gulu) Nucleoprotein / NP (aa361-aa738) Protein (His)
Virus E. coli
HY-P75716

Ebola virus VP40/Matrix VP40 Protein (B8XCM9, His)
Ebola virus EBOV (subtype Bundibugyo, strain Uganda 2007) VP40 / Matrix protein VP40 Protein (His)
Virus E. coli
HY-P75717

Ebola virus Glycoprotein/GP1 Protein (501a.a, Q7T9D9, sf9, His)
Ebola virus EBOV (subtype Sudan, strain Gulu) GP1 / Glycoprotein Protein (His)
Virus Sf9 insect cells
HY-P75718

Ebola virus Glycoprotein/GP1 Protein (501a.a, Q7T9D9, HEK293, His)
Ebola virus EBOV (subtype Sudan, strain Gulu) GP1 / Glycoprotein Protein (His)
Virus HEK293
HY-P75721

Ebola virus Glycoprotein/GP1 Protein (AHX24649, HEK293, His)
Ebola virus EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) GP1 / Glycoprotein Protein (His)
Virus HEK293
HY-P76884

Ebola virus Glycoprotein/GP1 Protein (Q7T9D9, sf9, His)
Ebola virus EBOV (Subtype Sudan, strain Gulu) Glycoprotein / GP1 (mucin domain deleted) Protein (His)
Virus Sf9 insect cells
HY-P76885

Ebola virus Glycoprotein/GP1 Protein (Q7T9D9, HEK293, His)
Ebola virus EBOV (Subtype Sudan, strain Gulu) Glycoprotein / GP1 (mucin domain deleted) Protein (His)
Virus HEK293
HY-P76887

Ebola virus Glycoprotein/GP1 Protein (AHX24649, sf9, His)
Ebola virus EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Glycoprotein / GP1 Protein (His)
Virus Sf9 insect cells
HY-P76888

Ebola virus Glycoprotein/GP Protein RBD (AHX24649, HEK293, Fc)
Ebola virus EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Glycoprotein / GP-RBD Protein (Fc)
Virus HEK293
HY-P76889

Ebola virus Glycoprotein/GP Protein RBD (AHX24649, HEK293, His)
Ebola virus EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Glycoprotein / GP-RBD Protein (His)
Virus HEK293
HY-P76890

Ebola virus Glycoprotein/GP2 Protein (AHX24649, HEK293, Fc)
Ebola virus EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) GP2 / Glycoprotein Protein (Fc)
Virus HEK293
HY-P76891

Ebola virus VP40/Matrix VP40 Protein (AHX24648, His)
Ebola virus EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Matrix protein VP40 Protein (His)
Virus E. coli

HY-P75274

Ebola virus Glycoprotein/GP Protein (AHX24649, HEK293, His) Ebola virus EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Glycoprotein / GP (Virion spike glycoprotein) Protein (His)	Virus	HEK293

HY-P75723

Ebola virus VP40/Matrix VP40 Protein (AHX24648, His-MBP) Ebola virus EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) VP40 / Matrix protein VP40 Protein (His-MBP)	Virus	E. coli

Cat. No.	Product Name

HY-B0005AS

Toremifene-d6
Toremifene-d₆ is deuterium labeled Toremifene. Toremifene (Z-Toremifene) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively[1][2].

HY-B0005S

Toremifene-d6 citrate
Toremifene-d₆ (citrate) is the deuterium labeled Toremifene citrate. Toremifene citrate (Z-Toremifene citrate) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively[1][2].

HY-13757AS1

Tamoxifen-d3

Tamoxifen-d₃ is the deuterium labeled Tamoxifen[1]. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[2][3][4]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively[6]. Tamoxifen activates autophagy and induces apoptosis[5]. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse[7].

EBOV

Inhibitors & Agonists

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Natural
Products