EDA

By Targets:	ADC Linker (3) Apoptosis (1) Bacterial (2) Drug-Linker Conjugates for ADC (2) Fluorescent Dye (2) HIV (1) Integrin (1) PROTAC Linkers (1) Reactive Oxygen Species (1) Reverse Transcriptase (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (5) Infection (3) Inflammation/Immunology (1)
Click Chemistry:	Azide (2) Alkynes (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D1603

BODIPY FL-EDA	Fluorescent Dye	Others
BODIPY FL-EDA is a fluorescent dye. BODIPY FL-EDA is an aliphatic-amine analog, and it can be coupled with aldehydes and ketones. BODIPY FL-EDA can be used for the detection of modified and normal deoxynucleotides and to determine DNA damage and genomic DNA methylation .

HY-147097A

EDA-DA TFA	Bacterial	Infection
EDA-DA is a N-terminally tagged dipeptide probe, can be used to label Peptidoglycan (PG) of bacteria. EDA-DA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .

HY-147097

EDA-DA	Bacterial	Infection
EDA-DA, a N-terminally tagged dipeptide probe, can be used to label Peptidoglycan (PG) of bacteria. Peptidoglycan (PG), an essential structure in the cell walls of the vast majority of bacteria, is critical for division and maintaining cell shape and hydrostatic pressure . EDA-DA is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-RS04151

EDA Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EDA Human Pre-designed siRNA Set A contains three designed siRNAs for EDA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EDA Human Pre-designed siRNA Set A EDA Human Pre-designed siRNA Set A

HY-RS04152

EDA2R Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EDA2R Human Pre-designed siRNA Set A contains three designed siRNAs for EDA2R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EDA2R Human Pre-designed siRNA Set A EDA2R Human Pre-designed siRNA Set A

HY-126673

Mal-C2-Gly3-EDA

ADC Linker Cancer

Mal-C2-Gly3-EDA is a cleavable ADC linker containing a Maleimide group. Mal-C2-Gly3-EDA is used for making antibody-drug conjugate.

Mal-C2-Gly3-EDA	ADC Linker	Cancer
Mal-C2-Gly3-EDA is a cleavable ADC linker containing a Maleimide group. Mal-C2-Gly3-EDA is used for making antibody-drug conjugate.

HY-145078

*PNU-EDA-Gly5*	Drug-Linker Conjugates for ADC	Cancer
PNU-EDA-Gly5 is an oligo-glycine linker-payload for ADC synthesis, composed of a DNA topoisomerase I inhibitor PNU-159682 and a linker EDA-Gly5 .

HY-130893

Biotin-EDA

PROTAC Linkers Cancer

Biotin-EDA is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
HY-D1395

RH-EDA

Reactive Oxygen Species Others

RH-EDA is a rhodamine-based turn-on fluorescent probe for detecting hydroxyl radicals in living systems.

Biotin-EDA	PROTAC Linkers	Cancer
Biotin-EDA is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

RH-EDA	Reactive Oxygen Species	Others
RH-EDA is a rhodamine-based turn-on fluorescent probe for detecting hydroxyl radicals in living systems.

HY-114346A

*BODIPY FL EDA* free base**	Fluorescent Dye	Others
ODIPY FL EDA free base is an amine-based, green fluorescent probe. The R-NH2 of ODIPY FL EDA free base can be coupled with aldehydes or ketones to form reversible Schiff base products. Convert to stable amine derivatives using reducing agents such as sodium borohydride or sodium cyanoborohydride. ODIPY FL EDA free base can be used to detect modified or normal deoxynucleotides and demonstrate DNA damage and genomic DNA methylation.

HY-126688

*Mal-C2-Gly3-EDA-PNU-159682*	Drug-Linker Conjugates for ADC	Cancer
Mal-C2-Gly3-EDA-PNU-159682, a agent-linker conjugate for ADC, consists a cleavable ADC linker Mal-C2-Gly3-EDA and a potent ADC cytotoxin PNU-159682.

HY-151842

*Fmoc-EDA-N3*	ADC Linker	Others
Fmoc-EDA-N3 is a click chemistry reagent containing an azide group . Fmoc-EDA-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-151829

*Fmoc-L-Asn(EDA-N3)-OH*	ADC Linker	Others
Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II .

HY-N2587

Irigenin	Integrin Apoptosis	Cancer
Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells .

HY-125810

4'-Ethynyl-2'-deoxyadenosine	HIV Reverse Transcriptase	Infection Inflammation/Immunology
4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC₅₀ of 98 nM in MT-4 cells for anti-HIV-1 activity . 4'-Ethynyl-2'-deoxyadenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name	Type

HY-D1603

BODIPY FL-EDA	Fluorescent Dyes/Probes
BODIPY FL-EDA is a fluorescent dye. BODIPY FL-EDA is an aliphatic-amine analog, and it can be coupled with aldehydes and ketones. BODIPY FL-EDA can be used for the detection of modified and normal deoxynucleotides and to determine DNA damage and genomic DNA methylation .

HY-114346A

*BODIPY FL EDA* free base**	Dyes
ODIPY FL EDA free base is an amine-based, green fluorescent probe. The R-NH2 of ODIPY FL EDA free base can be coupled with aldehydes or ketones to form reversible Schiff base products. Convert to stable amine derivatives using reducing agents such as sodium borohydride or sodium cyanoborohydride. ODIPY FL EDA free base can be used to detect modified or normal deoxynucleotides and demonstrate DNA damage and genomic DNA methylation.

BODIPY FL EDA free base

Dyes

ODIPY FL EDA free base is an amine-based, green fluorescent probe. The R-NH2 of ODIPY FL EDA free base can be coupled with aldehydes or ketones to form reversible Schiff base products. Convert to stable amine derivatives using reducing agents such as sodium borohydride or sodium cyanoborohydride. ODIPY FL EDA free base can be used to detect modified or normal deoxynucleotides and demonstrate DNA damage and genomic DNA methylation.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2587

Irigenin	Flavonoids Iridaceae Classification of Application Fields Source classification Phenols Polyphenols Plants Belamcanda chinensis (Linn.) Redouté Disease Research Fields Isoflavones Cancer	Integrin Apoptosis
Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells .

Species:	Human (4) Mouse (2) Rat (3) Cynomolgus (4)
Tag:	His (6) Fc (7)
Source:	HEK293 (13)

Cat. No.	Compare	Product Name	Species	Source

HY-P72663

	EDA2R/XEDAR Protein, Mouse (HEK293, His) Tumor necrosis factor receptor superfamily member 27; EDA-A2 receptor; EDA2R; TNFRSF27; XEDAR	Mouse	HEK293
	The EDA2R/XEDAR protein is a receptor for EDA isoform A2 (but not A1) and plays a key role in activating the NF-kappa-B and JNK pathways. This activation involves binding to TRAF3 and TRAF6, as indicated by protein similarity. EDA2R/XEDAR Protein, Mouse (HEK293, His) is the recombinant mouse-derived EDA2R/XEDAR protein, expressed by HEK293 , with C-6*His labeled tag. The total length of EDA2R/XEDAR Protein, Mouse (HEK293, His) is 138 a.a., with molecular weight of ~26 kDa.

HY-P75727

	EDA2R/XEDAR Protein, Human (HEK293, Fc) Tumor necrosis factor receptor superfamily member 27; EDA-A2 receptor; EDA2R; TNFRSF27; XEDAR	Human	HEK293
	The EDA2R/XEDAR protein acts as a receptor for the EDA isoform A2 (unlike A1) and is critical for activating the NF-kappa-B and JNK pathways. Its activation involves binding to TRAF3 and TRAF6. EDA2R/XEDAR Protein, Human (HEK293, Fc) is the recombinant human-derived EDA2R/XEDAR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EDA2R/XEDAR Protein, Human (HEK293, Fc) is 136 a.a., with molecular weight of ~41.3 kDa.

HY-P75728

	EDA2R/XEDAR Protein, Human (HEK293, His) Tumor necrosis factor receptor superfamily member 27; EDA-A2 receptor; EDA2R; TNFRSF27; XEDAR	Human	HEK293
	The EDA2R/XEDAR protein acts as a receptor for the EDA isoform A2 (unlike A1) and is critical for activating the NF-kappa-B and JNK pathways. Its activation involves binding to TRAF3 and TRAF6. EDA2R/XEDAR Protein, Human (HEK293, His) is the recombinant human-derived EDA2R/XEDAR protein, expressed by HEK293 , with N-His labeled tag. The total length of EDA2R/XEDAR Protein, Human (HEK293, His) is 138 a.a., with molecular weight of ~23-25 kDa.

HY-P75729

	EDA2R/XEDAR Protein, Mouse (HEK293, Fc) Tumor necrosis factor receptor superfamily member 27; EDA-A2 receptor; EDA2R; TNFRSF27; XEDAR	Mouse	HEK293
	The EDA2R/XEDAR protein is a receptor for EDA isoform A2 (but not A1) and plays a key role in activating the NF-kappa-B and JNK pathways. This activation involves binding to TRAF3 and TRAF6, as indicated by protein similarity. EDA2R/XEDAR Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EDA2R/XEDAR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EDA2R/XEDAR Protein, Mouse (HEK293, Fc) is 138 a.a., with molecular weight of ~49 kDa.

HY-P76312

	EDA2R/XEDAR Protein, Rat (HEK293, Fc) Tumor necrosis factor receptor superfamily member 27; EDA-A2 receptor; EDA2R; TNFRSF27; XEDAR	Rat	HEK293
	The EDA2R/XEDAR proteins lack conserved residues critical for feature annotation propagation and exhibit unique characteristics that raise questions about their structural and functional aspects. This uniqueness suggests potential changes in molecular interactions and signaling pathways. EDA2R/XEDAR Protein, Rat (HEK293, Fc) is the recombinant rat-derived EDA2R/XEDAR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EDA2R/XEDAR Protein, Rat (HEK293, Fc) is 136 a.a., with molecular weight of ~51 KDa.

HY-P76313

	EDA2R/XEDAR Protein, Rat (HEK293, His) Tumor necrosis factor receptor superfamily member 27; EDA-A2 receptor; EDA2R; TNFRSF27; XEDAR	Rat	HEK293
	The EDA2R/XEDAR proteins lack conserved residues critical for feature annotation propagation and exhibit unique characteristics that raise questions about their structural and functional aspects. This uniqueness suggests potential changes in molecular interactions and signaling pathways. EDA2R/XEDAR Protein, Rat (HEK293, His) is the recombinant rat-derived EDA2R/XEDAR protein, expressed by HEK293 , with C-His labeled tag. The total length of EDA2R/XEDAR Protein, Rat (HEK293, His) is 136 a.a., with molecular weight of ~24 KDa.

HY-P77353

	EDA2R/XEDAR Protein, Cynomolgus (HEK293, His) Tumor necrosis factor receptor superfamily member 27; EDA-A2 receptor; EDA2R; TNFRSF27; XEDAR	Cynomolgus	HEK293
	The EDA2R/XEDAR proteins lack conserved residues critical for feature annotation propagation and exhibit unique characteristics that raise questions about their structural and functional aspects. This uniqueness suggests potential changes in molecular interactions and signaling pathways. EDA2R/XEDAR Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived EDA2R/XEDAR protein, expressed by HEK293 , with C-His labeled tag. The total length of EDA2R/XEDAR Protein, Cynomolgus (HEK293, His) is 136 a.a., with molecular weight of ~25-29 KDa.

HY-P77354

	EDA2R/XEDAR Protein, Cynomolgus (HEK293, Fc) Tumor necrosis factor receptor superfamily member 27; EDA-A2 receptor; EDA2R; TNFRSF27; XEDAR	Cynomolgus	HEK293
	EDA2R Protein, also known as EDA-2R and TNFRSF27, is a transmembrane protein in the TNF receptor superfamily. EDA2R Protein is widely expressed, notably in embryonic basal epidermal cells and maturing hair follicles, and it does not contain a cytoplasmic death domain. EDA2R Protein can associate with Fas and induce EDA-A2 dependent apoptosis. EDA2R/XEDAR Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived EDA2R/XEDAR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EDA2R/XEDAR Protein, Cynomolgus (HEK293, Fc) is 136 a.a., with molecular weight of ~116 & 58 & 53 kDa, respectively.

HY-P75261

	EDAR Protein, Rat (HEK293, Fc) Tumor necrosis factor receptor superfamily member EDAR; EDA-A1 receptor; EDAR	Rat	HEK293
	EDAR Protein is a typical Tumor Necrosis Factor receptor (TNFR) family member. EDAR is a receptor for EDA isoform A1. Its binding results in recruitment of the intracellular EDAR-associated death domain (EDARADD) adapter protein and simultaneous activation of NF-kappa-B and JNK signaling pathways, potentially leading to various cellular responses. Additionally, EDAR may play a role in promoting caspase-independent cell death. EDAR Protein, Rat (HEK293, Fc) is the recombinant rat-derived EDAR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EDAR Protein, Rat (HEK293, Fc) is 161 a.a., with molecular weight of 60-70 kDa.

HY-P75262

	EDAR Protein, Human (HEK293, His) Tumor necrosis factor receptor superfamily member EDAR; EDA-A1 receptor; EDAR	Human	HEK293
	EDAR Protein, a receptor for EDA isoform A1, activates NF-kappa-B and JNK signaling pathways upon binding, eliciting diverse cellular responses. It may also contribute to caspase-independent cell death. EDAR forms a complex with EDARADD and associates with signaling molecules like TRAF1, TRAF2, TRAF3, and NIK, highlighting its participation in intricate signaling cascades. EDAR Protein, Human (HEK293, His) is the recombinant human-derived EDAR protein, expressed by HEK293 , with C-His labeled tag. The total length of EDAR Protein, Human (HEK293, His) is 163 a.a., with molecular weight of ~25-35 kDa.

HY-P75263

	EDAR Protein, Human (HEK293, Fc) Tumor necrosis factor receptor superfamily member EDAR; EDA-A1 receptor; EDAR	Human	HEK293
	EDAR Protein, a receptor for EDA isoform A1, activates NF-kappa-B and JNK signaling pathways upon binding, eliciting diverse cellular responses. It may also contribute to caspase-independent cell death. EDAR forms a complex with EDARADD and associates with signaling molecules like TRAF1, TRAF2, TRAF3, and NIK, highlighting its participation in intricate signaling cascades. EDAR Protein, Human (HEK293, Fc) is the recombinant human-derived EDAR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EDAR Protein, Human (HEK293, Fc) is 189 a.a., with molecular weight of ~52 kDa.

HY-P76895

	EDAR Protein, Cynomolgus (HEK293, Fc) Tumor necrosis factor receptor superfamily member EDAR; EDA-A1 receptor; EDAR	Cynomolgus	HEK293
	EDAR Protein, a receptor for EDA isoform A1, activates NF-kappa-B and JNK signaling pathways upon binding, eliciting diverse cellular responses. It may also contribute to caspase-independent cell death. EDAR forms a complex with EDARADD and associates with signaling molecules like TRAF1, TRAF2, TRAF3, and NIK, highlighting its participation in intricate signaling cascades. EDAR Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived EDAR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EDAR Protein, Cynomolgus (HEK293, Fc) is 187 a.a., with molecular weight of 60-64 kDa.

HY-P76896

EDAR Protein, Cynomolgus (HEK293, His)

Tumor necrosis factor receptor superfamily member EDAR; EDA-A1 receptor; EDAR
Cynomolgus HEK293


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Cat. No.	Product Name		Classification

HY-147097A

EDA-DA TFA		Alkynes
EDA-DA is a N-terminally tagged dipeptide probe, can be used to label Peptidoglycan (PG) of bacteria. EDA-DA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .

HY-147097

EDA-DA		Alkynes
EDA-DA, a N-terminally tagged dipeptide probe, can be used to label Peptidoglycan (PG) of bacteria. Peptidoglycan (PG), an essential structure in the cell walls of the vast majority of bacteria, is critical for division and maintaining cell shape and hydrostatic pressure . EDA-DA is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-151842

*Fmoc-EDA-N3*		Azide
Fmoc-EDA-N3 is a click chemistry reagent containing an azide group . Fmoc-EDA-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-151829

*Fmoc-L-Asn(EDA-N3)-OH*		Azide
Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II .

HY-125810

4'-Ethynyl-2'-deoxyadenosine		Alkynes
4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC₅₀ of 98 nM in MT-4 cells for anti-HIV-1 activity . 4'-Ethynyl-2'-deoxyadenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Fluorescent Dye

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