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EPZ-6438-d8

" in MCE Product Catalog:
Cat. No. Product Name Target Research Areas
  • HY-13803S
    Tazemetostat-d8

    EPZ-6438-d8; E-7438-d8

    Histone Methyltransferase Cancer
    Tazemetostat-d8 is deuterium labeled Tazemetostat. Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat (EPZ-6438) inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a Ki value of 2.5 nM. Tazemetostat (EPZ-6438) inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat (EPZ-6438) inhibits rat EZH2 with an IC50 of 4 nM. Tazemetostat (EPZ-6438) also inhibits EZH1 with an IC50 of 392 nM.