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Results for "

ER-stress

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (2) Akt (2) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (2) Apoptosis (42) ATF6 (1) Autophagy (10) Bacterial (2) Bcl-2 Family (2) Calcium Channel (1) Caspase (9) Cytochrome P450 (2) Deubiquitinase (2) E1/E2/E3 Enzyme (1) Endogenous Metabolite (11) ERK (7) Ferroptosis (1) Free Fatty Acid Receptor (1) Fungal (3) Glucosidase (1) HBV (1) HDAC (6) HIV (4) HSP (2) Influenza Virus (1) IRE1 (1) Isotope-Labeled Compounds (6) MDM-2/p53 (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (5) Mitophagy (2) NADPH Oxidase (1) NF-κB (5) NOD-like Receptor (NLR) (2) Nuclear Hormone Receptor 4A/NR4A (2) PAK (1) Paraptosis (1) Parasite (3) PDI (1) PERK (1) Phosphatase (1) PKG (2) PPAR (1) Reactive Oxygen Species (4) SARS-CoV (1) Sigma Receptor (1) TrxR (1) Virus Protease (4)
By Research Areas:	Cancer (46) Cardiovascular Disease (3) Endocrinology (1) Infection (12) Inflammation/Immunology (11) Metabolic Disease (8) Neurological Disease (7)

By Targets:

Adrenergic Receptor (2)

Akt (2)

Anaplastic lymphoma kinase (ALK) (1)

Antibiotic (2)

Apoptosis (42)

ATF6 (1)

Autophagy (10)

Bacterial (2)

Bcl-2 Family (2)

Calcium Channel (1)

Caspase (9)

Cytochrome P450 (2)

Deubiquitinase (2)

E1/E2/E3 Enzyme (1)

Endogenous Metabolite (11)

ERK (7)

Ferroptosis (1)

Free Fatty Acid Receptor (1)

Fungal (3)

Glucosidase (1)

HBV (1)

HDAC (6)

HIV (4)

HSP (2)

Influenza Virus (1)

IRE1 (1)

Isotope-Labeled Compounds (6)

MDM-2/p53 (1)

Microtubule/Tubulin (1)

Mitochondrial Metabolism (5)

Mitophagy (2)

NADPH Oxidase (1)

NF-κB (5)

NOD-like Receptor (NLR) (2)

Nuclear Hormone Receptor 4A/NR4A (2)

PAK (1)

Paraptosis (1)

Parasite (3)

PDI (1)

PERK (1)

Phosphatase (1)

PKG (2)

PPAR (1)

Reactive Oxygen Species (4)

SARS-CoV (1)

Sigma Receptor (1)

TrxR (1)

Virus Protease (4)

By Research Areas:

Cancer (46)

Cardiovascular Disease (3)

Endocrinology (1)

Infection (12)

Inflammation/Immunology (11)

Metabolic Disease (8)

Neurological Disease (7)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13814

PR-619 10+ Cited Publications	Deubiquitinase Autophagy Apoptosis	Cancer
PR-619 is a broad-range and reversible DUB inhibitor with EC₅₀s of 3.93, 4.9, 6.86, 7.2, and 8.61 μM for USP4, USP8, USP7, USP2, and USP5, respectively. PR-619 induces ER Stress and ER-Stress related apoptosis .

HY-136528

RA-9	Deubiquitinase Apoptosis	Cancer
RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor with favorable toxicity profile and anticancer activity. RA-9 blocks ubiquitin-dependent protein degradation without impacting 20S proteasome proteolytic activity. RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors. RA-9 induces endoplasmic reticulum (ER)-stress responses in ovarian cancer cells .

HY-131688

2-Chlorohexadecanoic acid	Others	Inflammation/Immunology
2-Chlorohexadecanoic acid, an inflammatory lipid mediator, interferes with protein palmitoylation,induces ER-stress markers, reduced the ER ATP content, and activates transcription and secretion of IL-6 as well as IL-8.2-Chlorohexadecanoic acid disrupts the mitochondrial membrane potential and induces procaspase-3 and PARP cleavage.2-Chlorohexadecanoic acid can across blood-brain barrier (BBB) and compromises ER- and mitochondrial functions in the human brain endothelial cell line hCMEC/D3 .

HY-147039

BOLD-100 free base NKP-1339 free base; IT-139 free base; KP-1339 free base	HSP Autophagy	Cancer
BOLD-100 (NKP-1339; IT-139) free base is a ruthenium-based anticancer agent. BOLD-100 free base also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 free base interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution .

HY-146786

ZMF-10	PAK Apoptosis	Cancer
ZMF-10 is a highly potent PAK1 inhibitor, with IC₅₀s of 174 nM, 1.038 μM and 1.372 μM for PAK1, PAK2 and PAK3, respectively. ZMF-10 can inhibit PAK1 activity to affect PAK1-regulated apoptosis, ER-Stress and migration in MDA-MB-231 cells. ZMF-10 can be used for researching anticancer .

HY-N1260

Scutebarbatine A (-)-Scutebarbatine A	Apoptosis	Cancer
Scutebarbatine A inhibits the proliferation of HCC cells and triggers their apoptosis via the activation of MAPK and ER stress .

HY-A0281

4-Phenylbutyric acid Maximum Cited Publications 111 Publications Verification 4-PBA; Benzenebutyric acid	HDAC Virus Protease	Infection Cancer
4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum *(ER)* stress, used in cancer and infection research.

HY-15654

Sodium 4-phenylbutyrate Maximum Cited Publications 111 Publications Verification 4-PBA sodium; 4-Phenylbutyric acid sodium; Benzenebutyric acid sodium	HDAC Autophagy Apoptosis	Cancer
Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum *(ER)* stress, used in cancer and infection research .

HY-128707

Z-LEVD-FMK

1 Publications Verification

Caspase Apoptosis Cancer

Z-LEVD-FMK is a cell-permeable caspase-4 inhibitor. Z-LEVD-FMK blocks ER stress-induced apoptosis in cancer cells .

Z-LEVD-FMK 1 Publications Verification	Caspase Apoptosis	Cancer
Z-LEVD-FMK is a cell-permeable caspase-4 inhibitor. Z-LEVD-FMK blocks ER stress-induced apoptosis in cancer cells .

HY-P0217

Microcystin-RR Cyanoviridin RR	Phosphatase Apoptosis	Metabolic Disease
Microcystin-RR (Cyanoviridin RR) is a potent and orally active protein phosphatase inhibitor. Microcystin-RR induces Apoptosis and ER stress in mice liver .

HY-18705

Azoramide 4 Publications Verification	Apoptosis Reactive Oxygen Species Caspase Bcl-2 Family Mitochondrial Metabolism	Endocrinology
Azoramide is a potent, orally active small-molecule modulator of the unfolded protein response (UPR). Azoramide improves ER protein folding and elevates ER chaperone capacity, which together protects cells against ER stress. Azoramide alleviates PLA2G6 mutant-induced ER stress through modulating unfolded protein response, and enhances the CERB signaling to rescue mitochondrial function, thereby preventing apoptosis of DA neurons. Azoramide has antidiabetic activity .

HY-121337

Flurochloridone R-40244	Apoptosis Bcl-2 Family	Others
Flurochloridone (R-40244) is a selective preemergence and persistent herbicide. Flurochloridone induces endoplasmic reticulum (ER) stress and activated unfolded protein response (UPR) signaling pathways. Flurochloridone impairs cell viability and induces cytotoxicity and apoptosis mediated by ER stress via activating eIF2α-ATF4/ATF6-CHOP-Bim/Bax signaling pathways in TM4 cells .

HY-19696

Tauroursodeoxycholate 55+ Cited Publications Tauroursodeoxycholic acid; TUDCA; UR 906	ERK Caspase Endogenous Metabolite Apoptosis	Cancer
Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-N1443

Demethylcantharidate disodium
Demethylcantharidate disodium, an endogenous metabolite, induces apoptosis in hepatocellular carcinoma cells via ER stress. Demethylcantharidate disodium shows excellent anticancer activity against multiple types of cancer .

HY-49116

CP26	Others	Infection Inflammation/Immunology
CP26 is a small molecule inhibitor of protein dislocation from the ER lumen to the cytosol. CP26 targets the Hrd1 complex, inhibits ERAD, and induces ER stress .

HY-N0878

Bufotalin 4 Publications Verification	Apoptosis Reactive Oxygen Species	Cancer
Bufotalin is a steroid lactone isolated from Venenum Bufonis with potently antitumor activities. Bufotalin induces cancer cell apoptosis and also induces endoplasmic reticulum (ER) stress activation .

HY-19696A

Tauroursodeoxycholate sodium 55+ Cited Publications Tauroursodeoxycholic acid sodium; TUDCA sodium; UR 906 sodium	ERK Caspase Apoptosis Endogenous Metabolite	Cancer
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-U00141

ABTL-0812 α-Hydroxylinoleic acid	Autophagy	Metabolic Disease
ABTL-0812 (α-Hydroxylinoleic acid) induces endoplasmic reticulum (ER) stress-mediated autophagy. ABTL-0812 is a first-in-class small molecule with anti-cancer activity .

HY-N0139

Troxerutin 1 Publications Verification Trihydroxyethylrutin	NOD-like Receptor (NLR)	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation.

HY-N1472

Levistolide A 1 Publications Verification
Levistolide A (LA), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is used for treating cancer. Levistolide A can induce apoptosis via ROS-mediated ER stress pathway .

HY-N3642

Cristacarpin ERythrabyssin I; ERythrabissin I	Others	Cancer
Cristacarpin can be extracted from the stem bark of Erythrina suberosa, promotes endoplasmic reticulum (ER) stress, leading to sublethal reactive oxygen species (ROS) production and ultimately cell death through senescence .

HY-137207

MK-28 3 Publications Verification	PERK	Neurological Disease
MK-28 is a potent and selective PERK activator. MK-28 exhibits remarkable pharmacokinetic properties and high BBB penetration in mice .

HY-19696B

Tauroursodeoxycholate dihydrate 55+ Cited Publications Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate	ERK Caspase Apoptosis Endogenous Metabolite	Cancer
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK .

HY-15654S

Phenylbutyrate-d11 sodium 4-PBA-d₁₁ sodium; 4-Phenylbutyric acid-d₁₁ sodium; Benzenebutyric acid-d₁₁ sodium	Isotope-Labeled Compounds HDAC Autophagy Apoptosis	Cancer
Phenylbutyrate-d₁₁ (sodium) is deuterium labeled Sodium 4-phenylbutyrate. Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research[1].

HY-A0281S

4-Phenylbutyric acid-d11 4-PBA-d₁₁; Benzenebutyric acid-d₁₁	HDAC Virus Protease	Infection Cancer
4-Phenylbutyric acid-d₁₁ is the deuterium labeled 4-Phenylbutyric acid. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.

HY-N0120A

Polydatin 5+ Cited Publications Piceid	Autophagy Apoptosis Mitophagy	Inflammation/Immunology Cancer
Polydatin (Piceid), extracted from the roots of Reynoutria japonica, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.

HY-W011241

Cinchonine hydrochloride (8R,9S)-Cinchonine hydrochloride; LA40221 hydrochloride	Apoptosis Parasite	Cancer
Cinchonine hydrochloride ((8R,9S)-Cinchonine hydrochloride) is a natural alkaloid present in Cinchona bark, with antimalarial activity. Cinchonine hydrochloride activates endoplasmic reticulum (ER) stress-induced apoptosis in human liver cancer cells .

HY-19696S

Tauroursodeoxycholate-d5	Isotope-Labeled Compounds ERK Caspase Endogenous Metabolite Apoptosis	Cancer
Tauroursodeoxycholate-d₅ is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696S1

Tauroursodeoxycholate-d4 Tauroursodeoxycholic acid-d₄; TUDCA-d₄; UR 906-d₄	Isotope-Labeled Compounds ERK Caspase Endogenous Metabolite Apoptosis	Cancer
Tauroursodeoxycholate-d₄ is deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696AS

Tauroursodeoxycholate-d4 sodium Tauroursodeoxycholic acid-d₄ sodium; TUDCA-d₄ sodium; UR 906-d₄ sodium	Isotope-Labeled Compounds ERK Caspase Apoptosis Endogenous Metabolite	Cancer
Tauroursodeoxycholate-d₄ (sodium) is the deuterium labeled Tauroursodeoxycholate sodium. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696S2

Tauroursodeoxycholate-d4-1 Tauroursodeoxycholic acid-d₄-1; TUDCA-d₄-1; UR 906-d₄-1	Isotope-Labeled Compounds ERK Caspase Endogenous Metabolite Apoptosis
Tauroursodeoxycholate-d₄-1 is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-A0281S3

4-Phenylbutyric acid-d2 4-PBA-d₂; Benzenebutyric acid-d₂	HDAC Virus Protease
4-Phenylbutyric acid-d₂ is the deuterium labeled 4-Phenylbutyric acid[1]. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.

HY-N11600

β-Apopicropodophyllin	Apoptosis	Cancer
β-Apopicropodophyllin is a nature product that could be isolated from Hyptis wticillata.β-Apopicropodophyllin induces apoptosis by inducing microtubule disruption, DNA damage, cell cycle arrest and ER stress. β-Apopicropodophyllin can be used in research of cancer .

HY-108434

Ceapin-A7 5+ Cited Publications	ATF6	Neurological Disease Metabolic Disease
Ceapin-A7 is a selective blocker of ATF6α signaling in response to ER stress, with an IC₅₀ of 0.59 μM. Ceapin-A7 can be used to explore both the mechanism of activation of ATF6α and its role in pathological settings .

HY-A0281S2

4-Phenylbutyric acid-d5 4-PBA-d₅; Benzenebutyric acid-d₅	HDAC Virus Protease
4-Phenylbutyric acid-d₅ is the deuterium labeled 4-Phenylbutyric acid[1]. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research[2][3][4].

HY-13433

Thapsigargin 50+ Cited Publications	Calcium Channel SARS-CoV Apoptosis	Infection Cancer
Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca ²⁺-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types .

HY-N0139R

Troxerutin (Standard) Trihydroxyethylrutin (Standard)	NOD-like Receptor (NLR)	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Troxerutin (Standard) is the analytical standard of Troxerutin. This product is intended for research and analytical applications. Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation.

HY-100430

CCF642	Apoptosis PDI	Cancer
CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC₅₀ of 2.9 μM. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity .

HY-N3239

Mulberrofuran G	NADPH Oxidase HBV
Mulberrofuran G protects ischemic injury-induced cell death via inhibition of NOX4-mediated ROS generation and ER stress . Mulberrofuran G shows moderate inhibiting activity of hepatitis B virus (HBV) DNA replication with IC₅₀ of 3.99 μM .

HY-101484A

NE-100 hydrochloride	Sigma Receptor	Neurological Disease
NE-100 (hydrochloride) is a potent and selective sigma-1 receptor antagonist with an IC₅₀ of 4.16 nM. NE-100 (hydrochloride) exerts antipsychotic activity in vivo[1]. NE-100 (hydrochloride) also suppresses ER stress-induced hippocampal cell death[2].

HY-12724

Guanabenz	Adrenergic Receptor Parasite	Cardiovascular Disease
Guanabenz is an orally active α-2-adrenoceptor agonist. Guanabenz has antihypertensive effect and antiparasitic activity. Guanabenz interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz also is used for the research of high blood pressure .

HY-12724A

Guanabenz hydrochloride	Parasite Adrenergic Receptor	Cardiovascular Disease
Guanabenz hydrochloride is an orally active α-2-adrenoceptor agonist. Guanabenz hydrochloride has antihypertensive effect and antiparasitic activity. Guanabenz hydrochloride interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz hydrochloride also is used for the research of high blood pressure .

HY-115901

4-PQBH	Nuclear Hormone Receptor 4A/NR4A Paraptosis	Cancer
4-PQBH is a potent Nur77 binder (K_D=1.17 μM). 4-PQBH extensively induces caspase-independent cytoplasmic vacuolization and paraptosis through Nur77-mediated ER stress and autophagy. 4-PQBH can be used for cancer research .

HY-N0120AR

Polydatin (Standard) 5+ Cited Publications Piceid (Standard)	Autophagy Apoptosis Mitophagy	Inflammation/Immunology Cancer
Polydatin (Standard) is the analytical standard of Polydatin. This product is intended for research and analytical applications. Polydatin (Piceid), extracted from the roots of Reynoutria japonica, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.

HY-123024

Cefatrizine BL-S-640; SK&F 60771	Apoptosis Bacterial Antibiotic	Infection Cancer
Cefatrizine (BL-S-640) is an orally active and broad-spectrum cephalosporin antibiotic. Cefatrizine is also a eEF2K inhibitor, with anti-proliferative activity in human breast cancer cells, which could induce ER stress, leading to cell death. Cefatrizine can be used in studies of cancer and bacterial infection .

HY-148755

ERX-41	Others	Cancer
ERX-41 is an orally active and stereospecific small molecule targeting to lysosomal acid lipase A (LIPA). ERX-41 induces endoplasmic reticulum (ER) stress resulting in cell death, indicating a function independent of LIPA but dependent on its ER localization. ERX-41 involves in a targeted strategy for solid tumors .

HY-19934A

Pifusertib hydrochloride TAS-117 hydrochloride	Akt Apoptosis Autophagy	Cancer
Pifusertib (TAS-117) hydrochloride is a potent, selective, orally active allosteric Akt inhibitor (with IC₅₀s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). Pifusertib hydrochloride triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. Pifusertib hydrochloride induces apoptosis and autophagy .

HY-131364

Nur77 modulator 1	Nuclear Hormone Receptor 4A/NR4A Apoptosis	Cancer
Nur77 modulator 1 is a good Nur77 binder (K_D = 3.58 μM). Nur77 modulator 1 up-regulates Nur77 expression, mediates sub-cellular localization of Nur77, induces Nur77-dependent ER stress and autophagy, and results in cell apoptosis. Anti-hepatoma activity .

HY-19934

Pifusertib TAS-117	Akt Apoptosis Autophagy	Cancer
Pifusertib (TAS-117) is a potent, selective, orally active allosteric Akt inhibitor (with IC₅₀s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). Pifusertib triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. Pifusertib induces apoptosis and autophagy .

HY-157158

TrxR-IN-6	TrxR Apoptosis	Cancer
TrxR-IN-6 (compound 1d) is a TrxR inhibitor that induces reactive oxygen species (ROS) accumulation and has anticancer activity. TrxR-IN-6 can further lead to redox system collapse, inducing mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and DNA damage. Finally, it causes oxidative stress and induces apoptosis .

Cat. No.	Product Name	Category	Target	Chemical Structure