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Elk1

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By Targets:	Akt (2) Aldose Reductase (1) Apoptosis (2) ERK (1) Phosphatase (2) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (4) Neurological Disease (2)
Click Chemistry:	Alkynes (2)

5

Inhibitors & Agonists

2

Peptides

1

Recombinant Proteins

1

Antibodies

2

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

ERK-IN-4	ERK	Cancer
ERK-IN-4 is an ERK inhibitor binds preferentially to ERK2 with a K_d of 5 μM. ERK-IN-4 specificity inhibits ERK Rsk-1 and Elk-1 phosphorylation. ERK-IN-4 has little effect on ERK protein phosphorylation by its upstream activator MEK1/2 ^[1].

TD52 1 Publications Verification	Apoptosis Phosphatase Akt	Cancer
TD52, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 has less p-EGFR inhibition and has potent anti-cancer activity ^[1]. TD52 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

TD52 dihydrochloride 1 Publications Verification	Akt Phosphatase Apoptosis	Cancer
TD52 dihydrochloride, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 dihydrochloride mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 dihydrochloride indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 dihydrochloride has less p-EGFR inhibition and has potent anti-cancer activity ^[1]. TD52 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

ELK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ELK1 Human Pre-designed siRNA Set A contains three designed siRNAs for ELK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ELK1 Human Pre-designed siRNA Set A ELK1 Human Pre-designed siRNA Set A

AKR1C3-IN-12	Aldose Reductase	Cancer
AKR1C3-IN-12 (compound 2j) is an aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ of 27 nM. AKR1C3-IN-12 enhances the efficacy of Gemcitabine and Cisplatin in bladder cancer ^[1].

Cat. No.	Product Name	Target	Research Area

TAT-DEF-Elk-1 1 Publications Verification TDE	Peptides	Neurological Disease
TAT-DEF-Elk-1 (TDE) is a cell-penetrating peptide inhibitor of Elk-1, mimics and specifically interferes with the DEF domain of Elk-1. TAT-DEF-Elk-1 blocks Elk-1 phosphorylation and prevents Elk-1 nuclear translocation without interfering with ERK nor MSK1 activation. TAT-DEF-Elk-1 is a useful tool to analyze the role of Elk-1 in this process during the development of neuronal plasticity ^[1].

*TAT-DEF-Elk-1* TFA** TDE TFA	Peptides	Neurological Disease
TAT-DEF-Elk-1 TFA (TDE TFA) is a cell-penetrating peptide inhibitor of Elk-1, mimics and specifically interferes with the DEF domain of Elk-1. TAT-DEF-Elk-1 TFA blocks Elk-1 phosphorylation and prevents Elk-1 nuclear translocation without interfering with ERK nor MSK1 activation. TAT-DEF-Elk-1 TFA is a useful tool to analyze the role of Elk-1 in this process during the development of neuronal plasticity ^[1].

Cat. No.	Compare	Product Name	Species	Source

	ELK1 Protein, Human (sf9, His-GST) ETS domain-containing protein Elk-1; Elk1	Human	Sf9 insect cells
	The ELK1 protein is a transcription factor that binds to purine-rich DNA and forms a ternary complex with SRF on the serum response element. It induces transcription, especially upon stimulation of the JNK signaling pathway. ELK1 Protein, Human (sf9, His-GST) is the recombinant human-derived ELK1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of ELK1 Protein, Human (sf9, His-GST) is 428 a.a., with molecular weight of ~73 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P83013

ELK1 Antibody (YA2758)

ETS domain-containing protein Elk-1
WB, IHC-P, IP, ChIP Human

Cat. No.	Product Name		Classification

TD52 1 Publications Verification		Alkynes
TD52, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 has less p-EGFR inhibition and has potent anti-cancer activity ^[1]. TD52 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

TD52 dihydrochloride 1 Publications Verification		Alkynes
TD52 dihydrochloride, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 dihydrochloride mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 dihydrochloride indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 dihydrochloride has less p-EGFR inhibition and has potent anti-cancer activity ^[1]. TD52 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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