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Epstein

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By Targets:	EBV (23) Apoptosis (2) Autophagy (1) CMV (1) DNA/RNA Synthesis (1) EBI2/GPR183 (2) HBV (1) HDAC (1) Histone Methyltransferase (1) HIV (1) HIV Protease (1) HPV (1) HSV (8) Influenza Virus (2) Interleukin Related (1) Nucleoside Antimetabolite/Analog (1) Parasite (1) Phosphatase (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (1) Infection (18) Inflammation/Immunology (6) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Antibodies

Targets Recommended: EBV

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P5482

Epstein-barr virus BRLF1 (134-142)	EBV	Others
Epstein-barr virus BRLF1 (134-142) is a biological active peptide. (HLA-A11 restricted epitope from Epstein-Barr Virus BRLF1 (134-142).)

HY-P1920

*CEF19, Epstein-Barr Virus latent NA-3A (458-466)*	EBV	Inflammation/Immunology
CEF19, Epstein-Barr Virus latent NA-3A (458-466) is a single peptide epitope, YPLHEQHGM, representing residues 458-466 of the type 1 Epstein-Barr Virus (EBV) nuclear antigen 3A protein (B95.8 strain). CEF19, Epstein-Barr Virus latent NA-3A (458-466) can significantly affect cytotoxic T-lymphocyte (CTL) recognition .

HY-P1911

*CEF27, Epstein-Barr Virus BRLF-1 lytic (148-156)*	EBV	Infection
CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 corresponding to amino acids 148-156 of the BRLF1 protein. BRLF1 is a transcriptional activator that binds directly to a GC-rich motif present in some Epstein-Barr virus (EBV) lytic gene promoters .

HY-N8041

Mogroside III A2	HSV	Infection
Mogroside III A2 is a cucurbitane glycoside. Mogroside III A2 can inhibit Epstein-Barr virus early antigen (EBV-EA) activation. Mogroside III A2 shows weak inhibitory effects on activation of NOR 1 .

HY-130789

Cimigenol-3-one

EBV Infection

Cimigenol-3-one inhibits Epstein-Barr virus early antigen (EBV-EA) activation .

Cimigenol-3-one	EBV	Infection
Cimigenol-3-one inhibits Epstein-Barr virus early antigen (EBV-EA) activation .

HY-131236

EBNA1-IN-SC7	EBV	Cancer
EBNA1-IN-SC7 (compound SC7) is a selective Epstein-Barr nuclear antigen 1 (EBNA1) inhibitor that interferes with EBNA1-DNA binding activity with an IC₅₀ value of 23 μM. EBNA1-IN-SC7 is used in EBV (Epstein-Barr virus)-related cancer research .

HY-101192

GSK682753A 2 Publications Verification	EBI2/GPR183	Inflammation/Immunology
GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC₅₀ of 53.6 nM.

HY-15489

Scriptaid 3 Publications Verification Scriptide; GCK1026	HDAC Autophagy Apoptosis Influenza Virus	Cancer
Scriptaid is a potent histone deacetylase (HDAC) inhibitor, used in cancer research. Scriptaid is also a sensitizer to antivirals and has potential for epstein-barr virus (EBV)-associated lymphomas treatment.

HY-P1890

CEF14, EBV Rta Protein (28-37)

EBV Infection

CEF14, EBV Rta Protein (28-37) is the HLA A24-restricted epitope from Epstein-Barr Virus Rta protein (28-37).

CEF14, EBV Rta Protein (28-37)	EBV	Infection
CEF14, EBV Rta Protein (28-37) is the HLA A24-restricted epitope from Epstein-Barr Virus Rta protein (28-37).

HY-N2432

Paederoside	EBV HBV	Infection Cancer
Paederoside is a monoterpene S-methyl thiocarbonate isolated from Paederia pertomentosa. Paederoside shows a high anti-tumor promoting activity against the Epstein-Barr virus activation .

HY-N3254

Minumicrolin Murpanidin; (+)-Murpanidin	HSV EBV	Infection
Minumicrolin is a plant growth inhibitor. Minumicrolin can be isolated from Murraya paniculata. Minumicrolin inhibits Epstein-Barr virus early antigen (EBV-EA) activation .

HY-N8459

α-Cembrenediol α-CBD	EBV	Cancer
α-Cembrenediol is a potent inhibitor of EBV.α-Cembrenediol inhibits the early antigen of the Epstein-Bar virus. α-Cembrenediol also has anti-tumour activity .

HY-16305

Maribavir Maximum Cited Publications 12 Publications Verification 1263W94; BW1263W94; GW257406X	EBV CMV	Infection
Maribavir is a potent inhibitor of histone phosphorylation catalyzed by wild-type pUL97 in vitro, with an IC₅₀ of 3 nM. Maribavir has potent antiviral activity against HCMV and Epstein-Barr virus (EBV).

HY-U00224

BRL44385	EBV HSV	Infection
BRL44385 is a potent and selective inhibitor of the replication of herpes simplex virus types 1 and 2 (HSV-1 and HSV2), varicella zoster virus (VZV) and Epstein-Barr virus (EBV).

HY-N8873

Silychristin B	Others	Cancer
Silychristin B is an antitumor promoter. Silychristin B inhibits TPA induced Epstein-Barr virus early antigen (EBV-EA) induction. Silychristin B can be isolated from milk thistle .

HY-P5475

BMLF1 (280–288)

EBV Others

BMLF1 (280–288) is a biological active peptide. (HLA A2.1-restricted epitope from Epstein-Barr Virus lytic protein BMLF1 (280-288).)
HY-P5470

LMP2A (426-434)

EBV Others

LMP2A (426-434) is a biological active peptide. (HLA A2.1-restricted epitope from Epstein-Barr Virus latent membrane protein LMP2 (426-434).)

BMLF1 (280–288)	EBV	Others
BMLF1 (280–288) is a biological active peptide. (HLA A2.1-restricted epitope from Epstein-Barr Virus lytic protein BMLF1 (280-288).)

LMP2A (426-434)	EBV	Others
LMP2A (426-434) is a biological active peptide. (HLA A2.1-restricted epitope from Epstein-Barr Virus latent membrane protein LMP2 (426-434).)

HY-12336

NIBR189 1 Publications Verification	EBV EBI2/GPR183	Inflammation/Immunology
NIBR189 is an EBI2 (Epstein-Barr virus-induced gene 2) antagonist. NIBR189 inhibits human and mouse EBI2 with IC₅₀s of 11 and 16 nM, respectively. NIBR189 can be used for the research of autoimmune diseases .

HY-N6033

Ferruginol (+)-Ferruginol	EBV HSV Apoptosis	Infection Cardiovascular Disease Neurological Disease Cancer
Ferruginol ((+)-Ferruginol), a natural diterpenoid, is an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). Ferruginol inhibits the growth of thyroid cancer cells through the induction of mitochondrial apoptosis. Ferruginol has antitumor, cardioprotective, antioxidant, gastroprotective, and neuroprotective activities .

HY-N2006

Ganoderic acid B
Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease (IC₅₀: 170 μM) .

HY-N7691

3,29-O-Dibenzoyloxykarounidiol Karounidiol dibenzoate	EBV	Infection Cancer
3,29-O-Dibenzoyloxykarounidiol (Karounidiol dibenzoate) is a triterpene benzoate isolated from the fruit of Momordica grosvenori. 3,29-O-Dibenzoyloxykarounidiol has potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) induced by tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) .

HY-133108

Azadirachtin B	EBV Parasite Phosphatase Influenza Virus	Infection Metabolic Disease Inflammation/Immunology Cancer
Azadirachtin B is an limonoid isolated from seed kernels of Azadirachta indica. Azadirachtin B increases alkaline phosphatase (ALP) activity and stimulates osteoblast differentiation. Azadirachtin B is active against the Epstein-Barr virus early antigen (EBV-EA). Azadirachtin B has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties .

HY-107801

Inosine pranobex 1 Publications Verification Imunovir; Delimmun; Groprinosin	Interleukin Related HSV HIV HPV	Infection Inflammation/Immunology
Inosine pranobex is an orally active immunomodulator. Inosine pranobex has broad-spectrum antiviral activity. Inosine pranobex inhibits human immunodeficiency virus (HIV), herpes simplex virus (HSV), vaccinia virus (VACV), human tumor virus (HPV), Cytomegalovirus, influenza virus (INFV), parainfluenza virus (PIV), and Epstein-Barr virus .

HY-N11020

Cabenoside D	EBV	Infection Inflammation/Immunology
Cabenoside D (compound 8) is a triterpenoid glycoside, which can be isolated from the methanol extract of lichen root. Cabenoside D shows anti-inflammatory activity and inhibits inflammation induced by 12-O-tetracylacyl hormone-13-acetate (TPA) in mice. Cabenoside D also inhibits TPA-induced Epstein-Barr virus (EBV) early antigen (EBV-EA) activation .

HY-148170

L-I-OddU	EBV DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection
L-I-OddU, a L-5'-halo- dioxolane nucleoside analogue, is a potent and selective *anti-Epstein-Barr virus (EBV)* agent with an EC₅₀ value of 0.03μM. L-I-OddU has low cytotoxicity with a CC₅₀ value of 1000 nM. L-I-OddU has antiviral activity by suppressing replicative EBV DNA and viral protein synthesis .

HY-149577

EBV lytic cycle inducer-1	EBV	Cancer
Epstein-Barr virus (EBV) lytic cycle inducer-1 Dp44mT (compound C7) is an iron-chelatoe-like compound. Dp44mT cooperates with HDAC inhibitor Romidespin (HY-15149) and SAHA to induce EBV lytic cycle. Dp44mT reactivates EBV lytic cycle by activating the ERK1/2-autophagy axis in epithelial cancers .

HY-N7040

11-Deoxymogroside IIE	HSV	Infection
11-Deoxymogroside IIE is a cucurbitane glycoside, isolated from Siraitia grosvenorii fruits. 11-Deoxymogroside IIE has inhibitory effect against Epstein Barr virus (EBV-EA) activation induced by TPA, shows weak inhibitory effect on (+/-)-(E)-methyl1-2-[E-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR1), a NO donor .

HY-120137

CMP-5	Histone Methyltransferase	Cancer
CMP-5 is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 prevents Epstein-Barr virus (EBV)-driven B-lymphocyte transformation but leaving normal B cells unaffected .

HY-N7041

11-Oxomogroside IIa	EBV HSV	Infection
11-Oxomogroside IIa (11-oxomogroside II A1) is a cucurbitane glycoside extracted from the fruits of Siraitia grosVenorii. 11-Oxomogroside IIa has inhibitory effects against the Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), shows weak inhibitory effects on activation of (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor .

HY-N11009

11-Oxomogroside II A1	EBV	Infection
11-Oxomogroside II A1 (compound 7) is an oxidized cucurbitin. It can be isolated from the ethanol extract of Rohanberry fruit. 11-Oxomogroside II A1 inhibits the activation of Epstein-Barr virus (EBV) early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). 11-Oxomogroside II A1 also weakly inhibits the activation of (±)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor .

HY-N4155

2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid	EBV HIV Protease HSV	Infection Cancer
2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid, a natural ursane-type triterpene, is a potent inhibitor of HIV protease (HIV Protease). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid is also an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid displays an inhibitory activity against nitric oxide production in Lipopolysaccharide (Lipopolysaccharides)-activated RAW 264.7 cells .

Epstein-barr virus BRLF1 (134-142)	EBV	Others
Epstein-barr virus BRLF1 (134-142) is a biological active peptide. (HLA-A11 restricted epitope from Epstein-Barr Virus BRLF1 (134-142).)

*CEF19, Epstein-Barr Virus latent NA-3A (458-466)*	EBV	Inflammation/Immunology
CEF19, Epstein-Barr Virus latent NA-3A (458-466) is a single peptide epitope, YPLHEQHGM, representing residues 458-466 of the type 1 Epstein-Barr Virus (EBV) nuclear antigen 3A protein (B95.8 strain). CEF19, Epstein-Barr Virus latent NA-3A (458-466) can significantly affect cytotoxic T-lymphocyte (CTL) recognition .

*CEF27, Epstein-Barr Virus BRLF-1 lytic (148-156)*	EBV	Infection
CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 corresponding to amino acids 148-156 of the BRLF1 protein. BRLF1 is a transcriptional activator that binds directly to a GC-rich motif present in some Epstein-Barr virus (EBV) lytic gene promoters .

CEF14, EBV Rta Protein (28-37)	EBV	Infection
CEF14, EBV Rta Protein (28-37) is the HLA A24-restricted epitope from Epstein-Barr Virus Rta protein (28-37).

BMLF1 (280–288)	EBV	Others
BMLF1 (280–288) is a biological active peptide. (HLA A2.1-restricted epitope from Epstein-Barr Virus lytic protein BMLF1 (280-288).)

LMP2A (426-434)	EBV	Others
LMP2A (426-434) is a biological active peptide. (HLA A2.1-restricted epitope from Epstein-Barr Virus latent membrane protein LMP2 (426-434).)

Paederoside	Infection Structural Classification Iridoids Classification of Application Fields Terpenoids Paederia scandens (Lour.) Merr. Source classification Rubiaceae Plants Disease Research Fields	EBV HBV
Paederoside is a monoterpene S-methyl thiocarbonate isolated from Paederia pertomentosa. Paederoside shows a high anti-tumor promoting activity against the Epstein-Barr virus activation .

α-Cembrenediol α-CBD	Structural Classification Natural Products Nicotiana tabacum L. Source classification Plants Solanaceae	EBV
α-Cembrenediol is a potent inhibitor of EBV.α-Cembrenediol inhibits the early antigen of the Epstein-Bar virus. α-Cembrenediol also has anti-tumour activity .

Mogroside III A2	Infection Triterpenes Classification of Application Fields Terpenoids Source classification Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields	HSV
Mogroside III A2 is a cucurbitane glycoside. Mogroside III A2 can inhibit Epstein-Barr virus early antigen (EBV-EA) activation. Mogroside III A2 shows weak inhibitory effects on activation of NOR 1 .

Cimigenol-3-one	Triterpenes Structural Classification Terpenoids Source classification Ranunculaceae Plants Cimicifuga foetida Linn.	EBV
Cimigenol-3-one inhibits Epstein-Barr virus early antigen (EBV-EA) activation .

Minumicrolin Murpanidin; (+)-Murpanidin	Structural Classification Natural Products Citrus × aurantiifolia (Christmann) Swingle Source classification Rutaceae Coumarins Phenylpropanoids Plants	HSV EBV
Minumicrolin is a plant growth inhibitor. Minumicrolin can be isolated from Murraya paniculata. Minumicrolin inhibits Epstein-Barr virus early antigen (EBV-EA) activation .

Silychristin B	Structural Classification Glycine soya Source classification Phenols Polyphenols Plants Compositae	Others
Silychristin B is an antitumor promoter. Silychristin B inhibits TPA induced Epstein-Barr virus early antigen (EBV-EA) induction. Silychristin B can be isolated from milk thistle .

Ferruginol (+)-Ferruginol	Structural Classification Cupressaceae Terpenoids Diterpenoids Thuja standishii (Gord.) Carr. Plants	EBV HSV Apoptosis
Ferruginol ((+)-Ferruginol), a natural diterpenoid, is an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). Ferruginol inhibits the growth of thyroid cancer cells through the induction of mitochondrial apoptosis. Ferruginol has antitumor, cardioprotective, antioxidant, gastroprotective, and neuroprotective activities .

Species:	Virus (2) Human (2) Mouse (1)
Tag:	His (5)
Source:	HEK293 (2) Sf9 insect cells (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P700202AF

	Animal-Free IL-27 EBI3 Protein, Mouse (His) Interleukin-27 subunit beta; IL-27 subunit beta; IL-27B; Epstein-Barr virus-induced gene 3 protein homolog	Mouse	E. coli
	IL-27 Proteinas, along with IL23A, forms the IL-23 interleukin, a key cytokine in innate and adaptive immunity. It's implicated in infection response, binding to the IL12RB1 and IL23R receptor complex, activating Jak-Stat signaling. IL-23 stimulates memory T-cells, promoting pro-inflammatory cytokine production. It contributes to autoimmune inflammation and is implicated in tumorigenesis. IL-12, a growth factor for activated T and NK cells, enhances NK cell lytic activity and stimulates interferon-gamma production by resting PBMC. Animal-Free IL-27 EBI3 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-27 EBI3 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free IL-27 EBI3 Protein, Mouse (His) is 206 a.a., with molecular weight of ~23.84 kDa.

HY-P75224

	Epstein-Barr virus Glycoprotein gp350/GP350 Protein (sf9, His) Envelope glycoprotein GP350; Membrane antigen; MA; BLLF1	Virus	Sf9 insect cells
	The Epstein-Barr viral glycoprotein gp350 (GP350) is critical for initiating attachment of viral particles to host B lymphocytes, a critical step in viral entry. By binding to host CR2 on B lymphocytes, GP350 promotes the subsequent binding of the viral glycoprotein gp42 to HLA class II molecules. Epstein-Barr virus Glycoprotein gp350/GP350 Protein (sf9, His) is the recombinant Virus-derived Epstein-Barr virus Glycoprotein gp350/GP350 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of Epstein-Barr virus Glycoprotein gp350/GP350 Protein (sf9, His) is 490 a.a., with molecular weight of ~53.7 kDa.

HY-P75225

	Epstein-Barr virus Glycoprotein gp350/GP350 Protein (HEK293, His) Envelope glycoprotein GP350; Membrane antigen; MA; BLLF1	Virus	HEK293
	The Epstein-Barr viral glycoprotein gp350 (GP350) is critical for initiating attachment of viral particles to host B lymphocytes, a critical step in viral entry. By binding to host CR2 on B lymphocytes, GP350 promotes the subsequent binding of the viral glycoprotein gp42 to HLA class II molecules. Epstein-Barr virus Glycoprotein gp350/GP350 Protein (HEK293, His) is the recombinant Virus-derived Epstein-Barr virus Glycoprotein gp350/GP350 protein, expressed by HEK293 , with C-His labeled tag. The total length of Epstein-Barr virus Glycoprotein gp350/GP350 Protein (HEK293, His) is 490 a.a., with molecular weight of ~53.7 kDa.

HY-P702625

	CCR7 Protein-Nanodisc, Human (HEK293, His) C-C CKR-7; CC-CKR-7; CCR-7; BLR2; CDw197; Epstein-Barr virus-induced G-protein coupled receptor 1 (EBI1; EBV-induced G-protein coupled receptor 1); MIP-3 beta receptor; CD197	Human	HEK293

HY-P700118AF

	Animal-Free IL-27 beta/EBI3 Protein, Human (His) Interleukin-27 subunit alpha; IL-27-A; Interleukin-27 subunit beta; IL-27B; Epstein-Barr virus-in_x0002_duced gene 3 protein; EBV-induced gene 3 protein; EBI3; p28; Interleukin-30; IL-30	Human	E. coli
	The IL-27 beta/EBI3 Protein, in conjunction with IL27, forms the IL-27 interleukin, pivotal in innate immunity. Possessing dual pro- and anti-inflammatory properties, IL-27 regulates T-helper cell development, inhibits T-cell proliferation, stimulates cytotoxic T-cell activity, induces B-cell isotype switching, and impacts innate immune cells. Under IL-27 influence, CD4 T-helper cells differentiate into TH1, TH2, and TH17 cells. IL-27 promotes rapid clonal expansion of naive CD4 T-cells, synergizes with IL-12 for IFN-gamma production, and contributes to antitumor and antiangiogenic activities through WSX-1/TCCR receptor activation. It forms heterodimers with IL27/IL27A (IL-27) and IL12A (IL-35), with no disulfide linkage, and interacts with SQSTM1. Animal-Free IL-27 beta/EBI3 Protein, Human (His) is the recombinant human-derived animal-FreeIL-27 beta/EBI3 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free IL-27 beta/EBI3 Protein, Human (His) is 209 a.a., with molecular weight of ~24.25 kDa.

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Epstein

Inhibitors & Agonists

Peptides

NaturalProducts

Recombinant Proteins

Antibodies

Natural
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