Search Result

Isoforms Recommended:	FGFR3

Results for "

FGFR3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (6) Aurora Kinase (1) c-Fms (4) c-Kit (5) CDK (1) Checkpoint Kinase (Chk) (1) EGFR (1) FAK (1) FGFR (48) FLT3 (4) HDAC (1) PDGFR (5) RET (1) Small Interfering RNA (siRNA) (3) SNIPERs (1) Src (3) Syk (1) VEGFR (7)
By Research Areas:	Cancer (46) Inflammation/Immunology (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148779

FGFR3-IN-5	FGFR	Cancer
FGFR3-IN-5 is a potent and selective *FGFR3* inhibitor with IC₅₀ values of 3, 44, and 289 nM for FGFR3, FGFR2, and FGFR1, respectively. FGFR3-IN-5 can be used in research of cancer .

HY-RS04918

FGFR3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FGFR3 Human Pre-designed siRNA Set A contains three designed siRNAs for FGFR3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FGFR3 Human Pre-designed siRNA Set A FGFR3 Human Pre-designed siRNA Set A

HY-RS04919

Fgfr3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fgfr3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fgfr3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fgfr3 Mouse Pre-designed siRNA Set A Fgfr3 Mouse Pre-designed siRNA Set A

HY-RS04920

Fgfr3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fgfr3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fgfr3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fgfr3 Rat Pre-designed siRNA Set A Fgfr3 Rat Pre-designed siRNA Set A

HY-148778

FGFR3-IN-4

FGFR Cancer

FGFR3-IN-4 is a selective FGFR3 inhibitor, with an IC₅₀ value of less than 50 nM. FGFR3-IN-4 is at least 10 fold more selective for FGFR3 than for FGFR1 .

FGFR3-IN-4	FGFR	Cancer
FGFR3-IN-4 is a selective *FGFR3* inhibitor, with an IC₅₀ value of less than 50 nM. FGFR3-IN-4 is at least 10 fold more selective for FGFR3 than for FGFR1 .

HY-147714

FGFR3-IN-2	FGFR VEGFR	Cancer
FGFR3-IN-2 (compound 18b) is a potent and selective *FGFR3* inhibitor, with IC₅₀s of 4.1 nM and 570 nM for *FGFR3* and VEGFR2, respectively. FGFR3-IN-2 can be used for the research of bladder cancer .

HY-156790

FGFR3-IN-6

FGFR Cancer

FGFR3-IN-6 is a potent and selective FGFR3 inhibitor with IC₅₀ value less than 350 nM. FGFR3-IN-6 can be used in research of cancer .
HY-156791

FGFR3-IN-7

FGFR Cancer

FGFR3-IN-7 is a potent and selective FGFR3 inhibitor with IC₅₀ value less than 350 nM. FGFR3-IN-7 can be used in research of cancer .
HY-158010

FGFR3-IN-8

FGFR Cancer

FGFR3-IN-8 (example91) is a selective FGFR3 inhibitor .
HY-158011

FGFR3-IN-9

FGFR Cancer

FGFR3-IN-9 (example27) is a selective FGFR3 inhibitor .

FGFR3-IN-6	FGFR	Cancer
FGFR3-IN-6 is a potent and selective FGFR3 inhibitor with IC₅₀ value less than 350 nM. FGFR3-IN-6 can be used in research of cancer .

FGFR3-IN-7	FGFR	Cancer
FGFR3-IN-7 is a potent and selective FGFR3 inhibitor with IC₅₀ value less than 350 nM. FGFR3-IN-7 can be used in research of cancer .

FGFR3-IN-8	FGFR	Cancer
FGFR3-IN-8 (example91) is a selective *FGFR3* inhibitor .

FGFR3-IN-9	FGFR	Cancer
FGFR3-IN-9 (example27) is a selective *FGFR3* inhibitor .

HY-147713

FGFR3-IN-1	FGFR	Cancer
FGFR3-IN-1 (compound 1) is a fibroblast growth factor receptor (FGFR) inhibitor, with IC₅₀s of 40 nM, 5.1 nM, and 12 nM for *FGFR1, 2, and 3, respectively. FGFR3*-IN-1 can be used for the research of bladder cancer .

HY-147715

FGFR3-IN-3	FGFR	Cancer
FGFR3-IN-3 (compound 40a) is a potent and pan-FGFR inhibitor, with IC₅₀s of 2.1 nM, 3.1 nM, 4.3 nM and 74 nM for *FGFR1, 2, 3, and 4, respectively. FGFR3*-IN-3 can be used for the research of bladder cancer .

HY-151903S

FGFR2/3-IN-1	FGFR	Cancer
FGFR2/3-IN-1 is a potent and selective FGFR2 and FGFR3 (FGFR) inhibitor with IC50s of 1 nM and 0.5 nM, respectively. FGFR2/3-IN-1 displays >40-fold selectivity over FGFR1/FGFR4 and other kinome. FGFR2/3-IN-1 also inhibits FGFR3 V555L and V555M mutants with IC50s of 2.7 nM and 6.1 nM, respectively[1].

HY-145895

SNIPER(TACC3)-11	FGFR SNIPERs	Cancer
SNIPER(TACC3)-11 is a potent *FGFR3-TACC3* degrader. SNIPER(TACC3)-11 reduces FGFR3-TACC3 protein levels and suppressed the growth of FGFR3-TACC3 positive cancer cells .

HY-P3695

VSPPLTLGQLLS	FGFR	Cancer
VSPPLTLGQLLS is a small peptide *FGFR3* inhibitor, peptide P3, inhibits *FGFR3* phosphorylation. VSPPLTLGQLLS inhibits 9-cisRA-induced tracheal lymphangiogenesis and blocks lymphatic endothelial cell (LEC) proliferation, migration, and tubule formation .

HY-P3695A

VSPPLTLGQLLS TFA	FGFR	Cancer
VSPPLTLGQLLS TFA is a small peptide *FGFR3* inhibitor, peptide P3, inhibits *FGFR3* phosphorylation. VSPPLTLGQLLS TFA inhibits 9-cisRA-induced tracheal lymphangiogenesis and blocks lymphatic endothelial cell (LEC) proliferation, migration, and tubule formation .

HY-P99823

Recifercept TA-46; sFGFR3	FGFR	Others
Recifercept (TA-46) is a soluble, recombinant fibroblast growth factor receptor 3 (FGFR3) molecule. Recifercept can be used as a decoy/ligand trap to decrease the amount of fibroblast growth factors that can bind to mutant FGFR3 receptors. Recifercept can be used for the research of achondroplasia .

HY-18602

FIIN-2

FGFR Cancer

FIIN-2 is an irreversible inhibitor of FGFR with an IC₅₀ of 3.1, 4.3, 27, and 45 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively.
HY-145043

FGFR-IN-1

FGFR Cancer

FGFR-IN-1 is a potent FGFR inhibitor with an IC₅₀ of <100 nM for FGFR1, FGFR2, and FGFR3, respectively (patent US20130338134A1, example 219) .
HY-18603

FIIN-3

EGFR FGFR Cancer

FIIN-3 is an irreversible inhibitor of FGFR with an IC₅₀ of 13.1, 21, 31.4, and 35.3 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively.
HY-13304

LY2874455

3 Publications Verification

FGFR Cancer

LY2874455 is a pan-FGFR inhibitor with IC₅₀s of 2.8, 2.6, 6.4, 6 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively.
HY-101466

E7090

FGFR Cancer

E7090 is an orally available, potent, and selective FGFR inhibitor with IC₅₀s of 0.71 nM, 0.50 nM, 1.2 nM, and 120 nM for FGFR1/FGFR2/FGFR3/FGFR4, respectively .

FIIN-2	FGFR	Cancer
FIIN-2 is an irreversible inhibitor of *FGFR* with an IC₅₀ of 3.1, 4.3, 27, and 45 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively.

FGFR-IN-1	FGFR	Cancer
FGFR-IN-1 is a potent *FGFR* inhibitor with an IC₅₀ of <100 nM for FGFR1, FGFR2, and FGFR3, respectively (patent US20130338134A1, example 219) .

FIIN-3	EGFR FGFR	Cancer
FIIN-3 is an irreversible inhibitor of *FGFR* with an IC₅₀ of 13.1, 21, 31.4, and 35.3 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively.

LY2874455 3 Publications Verification	FGFR	Cancer
LY2874455 is a *pan-FGFR* inhibitor with IC₅₀s of 2.8, 2.6, 6.4, 6 nM for *FGFR1, FGFR2, FGFR3, FGFR4*, respectively.

E7090	FGFR	Cancer
E7090 is an orally available, potent, and selective *FGFR* inhibitor with IC₅₀s of 0.71 nM, 0.50 nM, 1.2 nM, and 120 nM for *FGFR1/FGFR2/FGFR3/FGFR4*, respectively .

HY-19957

Zoligratinib 2 Publications Verification Debio 1347; CH5183284	FGFR	Cancer
Zoligratinib (Debio 1347) is an orally available and selective *FGFR* inhibitor with IC₅₀s of 9.3, 7.6, and 22 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.

HY-145231

FGFR2-IN-2

FGFR Cancer

FGFR2-IN-2 (Compound 38) is a selective FGFR2 inhibitor with IC₅₀s of 389, 29, and 758 nM for FGFR1, FGFR2, and FGFR3, respectively .

FGFR2-IN-2	FGFR	Cancer
FGFR2-IN-2 (Compound 38) is a selective *FGFR2* inhibitor with IC₅₀s of 389, 29, and 758 nM for FGFR1, FGFR2, and FGFR3, respectively .

HY-13330

Fexagratinib 15+ Cited Publications AZD4547; ADSK091	FGFR	Cancer
Fexagratinib (AZD4547; ADSK091) is a potent inhibitor of the *FGFR* family with IC₅₀s of 0.2 nM, 2.5 nM, 1.8 nM, and 165 nM for *FGFR1, FGFR2, FGFR3, and FGFR4*, respectively.

HY-13311A

Infigratinib phosphate Maximum Cited Publications 25 Publications Verification BGJ-398 phosphate; NVP-BGJ398 phosphate	FGFR	Cancer
Infigratinib phosphate (BGJ-398 phosphate; NVP-BGJ398 phosphate) is a potent inhibitor of the *FGFR* family with IC₅₀ of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for *FGFR1, FGFR2, FGFR3, and FGFR4*, respectively.

HY-P99384

Vofatamab B-701; MFGR-1877S; RG-7444	FGFR	Cancer
Vofatamab (B-701) is an anti-FGFR3 monoclonal antibody (mAb). Vofatamab blocks activation of both the wildtype and genetically activated receptor. Vofatamab can be used in the research of metastatic urothelial carcinoma (mUC) .

HY-13311

Infigratinib Maximum Cited Publications 25 Publications Verification BGJ-398; NVP-BGJ398	FGFR Apoptosis	Cancer
Infigratinib (BGJ-398; NVP-BGJ398) is a potent inhibitor of the *FGFR* family with IC₅₀s of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for *FGFR1, FGFR2, FGFR3, and FGFR4*, respectively.

HY-13311S

Infigratinib-d3 BGJ-398-d₃; NVP-BGJ398-d₃	FGFR	Cancer
Infigratinib-d3 is a deuterated analog of infigratinib. Infigratinib is an effective inhibitor of the *FGFR* family, with IC₅₀ values of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for *FGFR1, FGFR2, FGFR3, and FGFR4*, respectively .

HY-150652

FGFR-IN-8	FGFR Apoptosis	Cancer
FGFR-IN-8 (Compound 17a) is a highly potent and orally active panFGFR inhibitor against wild-type and mutant FGFRs. FGFR-IN-8 shows inhibition with IC₅₀ values of <0.5, 189.1, <0.5, 22.6, <0.5 and 7.30 nM against FGFR1, V564F-FGFR2, N549H-FGFR2, V555M-FGFR3, FGFR3 and FGFR4, respectively. GFR-IN-8 induces cancer cell apoptosis and shows anticancer activities .

HY-109099

Pemigatinib 5+ Cited Publications INCB054828	FGFR	Cancer
Pemigatinib (INCB054828) is an orally active, selective *FGFR* inhibitor with IC₅₀s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively. Pemigatinib has the potential for cholangiocarcinoma .

HY-101466A

E7090 succinate	FGFR	Cancer
E7090 succinate is an orally available, selective and potent inhibitor of **FGFR1, FGFR2 and FGFR3 tyrosine kinase activities, with IC₅₀** values of 0.71 nM, 0.50 nM, 1.2 nM, and 120 nM for FGFR1/2/3/4, respectively .

HY-142921

FGFR-IN-2	FGFR	Cancer
FGFR-IN-2 (compound 1) is a potent *FGFR* inhibitor with IC₅₀s of 7.3 nM, 4.3 nM, 7.6 nM, 11 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively. FGFR-IN-2 has the potential for cancer research .

HY-P3503

Vosoritide BMN 111	FGFR	Others
Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of *FGFR3* (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research ^[3].

HY-152104

FGFR-IN-9	FGFR	Cancer
FGFR-IN-9 (Compound 19) is a potent, reversible and orally active *FGFR* inhibitor with an IC₅₀ of 17.1, 29.6, 30.7, 46.7 and 64.3 nM against FGFR4 ^WT, FGFR3, FGFR4 ^V550L, FGFR2 and FGFR1, respectively .

HY-101768

PRN1371 1 Publications Verification	FGFR c-Fms	Cancer
PRN1371 is a highly selective and potent *FGFR1-4* and CSF1R inhibitor with IC₅₀s of 0.6, 1.3, 4.1, 19.3 and 8.1 nM for FGFR1, FGFR2, FGFR3, FGFR4 and CSF1R, respectively .

HY-146541

FGFR4-IN-10	FGFR	Cancer
FGFR4-IN-10 (compound 5a) is a potent and selective *FGFR4* inhibitor with an IC₅₀ value of 70.7 nM. FGFR4-IN-10 shows no inhibition against other FGFR family members, i.e. FGFR1, FGFR2 and FGFR3 .

HY-50905S

Dovitinib-d8	FLT3 c-Kit FGFR VEGFR PDGFR c-Fms	Cancer
Dovitinib-d₈ is the deuterium labeled Dovitinib. Dovitinib (CHIR-258) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/FGFR3, VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ, respectively[1][2].

HY-135960

BO-264	FGFR Apoptosis	Cancer
BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC₅₀ of 188 nM and a K_d of 1.5 nM. BO-264 specifically blocks the function of *FGFR3-TACC3* fusion protein. BO-264 induces spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis. BO-264 has broad-spectrum antitumor activity .

HY-100019

Rogaratinib 5 Publications Verification BAY1163877	FGFR	Cancer
Rogaratinib (BAY1163877) is a potent and selective fibroblast growth factor receptor (FGFR) inhibitor. Rogaratinib inhibits FGFRs with IC50s of 11.2 nM (FGFR1), <1 nM (FGFR2), 18.5 nM (FGFR3), 127 nM (VEGFR3/FLT4), 201 nM (FGFR4), respectively .

HY-119367

ODM-203	FGFR VEGFR	Cancer
ODM-203 is an orally active and selective *FGFR/VEGFR* inhibitor with IC₅₀ values of 6, 11, 16, 5, 9, 26 and 35 nM for *FGFR3/1/2* and *VEGFR3/2/1/4*, respectively. ODM-203 has strong anti-tumour activity and activates immune responses in the tumour microenvironment .

HY-163273

FGFR4-IN-17	FGFR	Cancer
FGFR4-IN-17 (Compound (S)-23) is a piperazinyl diflurindan derivative containing pyridinyl. FGFR4-IN-17 is a *FGFR* inhibitor with IC₅₀ values of 24.2, 16.1, 78.0, and 68.0 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. FGFR4-IN-17 has antitumor activity .

HY-50905

Dovitinib 5+ Cited Publications CHIR-258; TKI258	FLT3 c-Kit FGFR VEGFR PDGFR c-Fms	Cancer
Dovitinib (CHIR-258) is an orally active, potent multi-targeted tyrosine kinase (RTK) inhibitor with IC₅₀s of 1, 2, 36, 8/9, 10/13/8, 27/210 nM for *FLT3, c-Kit, CSF-1R, FGFR1/FGFR3, VEGFR1/VEGFR2/VEGFR3* and PDGFRα/PDGFRβ, respectively. Dovitinib has potent antitumor activity .

HY-155028

FGFR-IN-11	FGFR	Cancer
FGFR-IN-11 (compound I-5) is an orally active and covalent *FGFR* inhibitor with IC₅₀ values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (FGFR4), respectively. FGFR-IN-11 inhibits multiple cancer cell proliferation with nanomolar activity. FGFR-IN-11 inhibits tumor growth significantly in xenograft mice models .

HY-10209

Masitinib 5 Publications Verification AB1010	c-Kit PDGFR Src FGFR FAK Apoptosis	Cancer
Masitinib (AB1010) is a potent, orally bioavailable, and selective inhibitor of c-Kit (IC₅₀=200 nM for human recombinant c-Kit). It also inhibits PDGFRα/β (IC₅₀s=540/800 nM), Lyn (IC₅₀= 510 nM for LynB), Lck, and, to a lesser extent, *FGFR3* and FAK. Masitinib (AB1010) has anti-proliferative, pro-apoptotic activity and low toxicity .

HY-10209A

Masitinib mesylate 5 Publications Verification AB-1010 mesylate	c-Kit PDGFR Src FGFR Apoptosis	Cancer
Masitinib mesylate (AB-1010 mesylate) is a potent, orally bioavailable, and selective inhibitor of c-Kit (IC₅₀=200 nM for human recombinant c-Kit). It also inhibits PDGFRα/β (IC₅₀s=540/800 nM), Lyn (IC₅₀= 510 nM for LynB), Lck, and, to a lesser extent, *FGFR3* and FAK. Masitinib mesylate (AB-1010 mesylate) has anti-proliferative, pro-apoptotic activity and low toxicity .

HY-10032

PF 477736 5 Publications Verification PF 00477736	Checkpoint Kinase (Chk) VEGFR Src c-Fms Aurora Kinase FGFR FLT3 RET CDK	Cancer
PF 477736 (PF 00477736) is a potent, selective and ATP-competitive inhibitor of Chk1, with a K_i of 0.49 nM, it is also a Chk2 inhibitor, with a K_i of 47 nM. PF 477736 shows <100-fold selectivity for Chk1 over VEGFR2, Fms, Yes, Aurora-A, *FGFR3, Flt3, and Ret* (IC₅₀=8 (K_i), 10, 14, 23, 23, 25, and 39 nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo .

HY-108933

JK-P3	VEGFR FGFR	Cancer
JK-P3 is a potent and pan VEGFR2 inhibitor, with IC₅₀s of 7.83 μM, 27 μM and 5.18 μM for VEGFR2, FGFR1 and FGFR3, respectively. JK-P3 can inhibit VEGF-A-stimulated VEGFR2 activation and intracellular signalling, also inhibits endothelial monolayer wound closure and angiogenesis, as well as fibroblast growth factor receptor kinase activity in vitro. JK-P3 has anti-angiogenic activity .

HY-152146

HDAC-IN-50	Apoptosis FGFR HDAC	Cancer
HDAC-IN-50 is a potent and orally active *FGFR* and HDAC dual inhibitor with IC₅₀ values of 0.18, 1.2, 0.46, 1.4, 1.3, 1.6, 2.6, 13 nM for FGFR1, FGFR2, FGFR3, FGFR4, HDAC1, HDAC2, HDAC6, HDAC8, respectively. HDAC-IN-50 induces Apoptosis and cell cycle arrest at G0/G1 phase. HDAC-IN-50 decreases the expression of pFGFR1, pERK, pSTAT3. HDAC-IN-50 shows anti-tumor activity .

HY-109082

Cevidoplenib SKI-O-703	Syk	Inflammation/Immunology
Cevidoplenib (SKI-O-703) is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities. Cevidoplenib is also the mesylate form of SKI-O-592. Cevidoplenib and SKI-O-592 inhibits BCR-mediated survival, proliferation, and differentiation of B cells. And SKI-O-592 potently inhibits multiple kinases with IC₅₀s of 6.2 nM (Syk), 1.859 μM (Jak2), 5.807 μM (Jak3), 0.412 μM (RET), 0.687 μM (KOR), 1.783 μM (FLT3), 16.96 μM (FGFR1), 5.662 μM (FGFR3), and 0.709 μM (Pyk2), respectively ^[3].

Cat. No.	Product Name	Target	Research Area

HY-P3695

VSPPLTLGQLLS	FGFR	Cancer
VSPPLTLGQLLS is a small peptide *FGFR3* inhibitor, peptide P3, inhibits *FGFR3* phosphorylation. VSPPLTLGQLLS inhibits 9-cisRA-induced tracheal lymphangiogenesis and blocks lymphatic endothelial cell (LEC) proliferation, migration, and tubule formation .

HY-P3695A

VSPPLTLGQLLS TFA	FGFR	Cancer
VSPPLTLGQLLS TFA is a small peptide *FGFR3* inhibitor, peptide P3, inhibits *FGFR3* phosphorylation. VSPPLTLGQLLS TFA inhibits 9-cisRA-induced tracheal lymphangiogenesis and blocks lymphatic endothelial cell (LEC) proliferation, migration, and tubule formation .

HY-P3503

Vosoritide BMN 111	FGFR	Others
Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of *FGFR3* (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research ^[3].

Cat. No.	Product Name	Target	Research Area

HY-P99823

Recifercept TA-46; sFGFR3	FGFR	Others
Recifercept (TA-46) is a soluble, recombinant fibroblast growth factor receptor 3 (FGFR3) molecule. Recifercept can be used as a decoy/ligand trap to decrease the amount of fibroblast growth factors that can bind to mutant FGFR3 receptors. Recifercept can be used for the research of achondroplasia .

HY-P99384

Vofatamab B-701; MFGR-1877S; RG-7444	FGFR	Cancer
Vofatamab (B-701) is an anti-FGFR3 monoclonal antibody (mAb). Vofatamab blocks activation of both the wildtype and genetically activated receptor. Vofatamab can be used in the research of metastatic urothelial carcinoma (mUC) .

Recombinant Proteins Recommended:

FGFR-3

Species:	Human (14) Rhesus Macaque (1) Mouse (3) Cynomolgus (1)
Tag:	His (16) Avi (8) Fc (4) B2M (1) Flag (1)
Source:	HEK293 (16) Sf9 insect cells (1) P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P70817

	FGFR-3 Protein, Human (HEK293, Fc) 1 Publications Verification Fibroblast growth factor receptor 3; FGFR-3; CD333; FGFR3; JTK4; IIIc	Human	HEK293
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 Protein, Human (HEK293, Fc) is the recombinant human-derived FGFR-3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-3 Protein, Human (HEK293, Fc) is 353 a.a., with molecular weight of 95-110 kDa.

HY-P72644

	FGFR-3 Protein, Human (HEK293, His) Fibroblast growth factor receptor 3; FGFR-3; CD333; JTK4	Human	HEK293
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 Protein, Human (HEK293, His) is the recombinant human-derived FGFR-3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FGFR-3 Protein, Human (HEK293, His) is 353 a.a., with molecular weight of 60-75 kDa.

HY-P74153

	FGFR-3 Protein, Mouse (HEK293, His) Fibroblast growth factor receptor 3; FGFR-3; CD333; Mfr3; Sam3	Mouse	HEK293
	The FGFR-3 protein is a tyrosine protein kinase that serves as a cell surface receptor for fibroblast growth factors and controls cellular processes, including proliferation, differentiation, and apoptosis. It is essential for chondrocyte differentiation, proliferation, apoptosis and normal bone development functions. FGFR-3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FGFR-3 protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-3 Protein, Mouse (HEK293, His) is 347 a.a., with molecular weight of 60-90 kDa.

HY-P73056

	FGFR-3 Protein, Mouse (HEK293, His-Fc) Fibroblast growth factor receptor 3; FGFR-3; CD333; JTK4	Mouse	HEK293
	The FGFR-3 Protein is a member of the fibroblast growth factor receptor family. FGFR-3 Protein regulates chondrocyte differentiation and chondrocyte proliferation by activating the MAPK/STAT signaling pathway. FGFR-3 mutations are also associated with sperm cell tumors. FGFR-3 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived FGFR-3 protein, expressed by HEK293, with C-hFc, C-His labeled tag. The total length of FGFR-3 Protein, Mouse (HEK293, His-Fc) is 367 a.a., with molecular weight of 100-110 kDa.

HY-P71954

	FGFR-3 Protein, Human (HEK293, hFc) ACH; CD 333; CD333; CD333 antigen; CEK 2; CEK2; FGFR 3; FGFR-3; FGFR3; FGFR3_HUMAN; Fibroblast growth factor receptor 3 achondroplasia thanatophoric dwarfism; ; Fibroblast growth factor receptor 3; Heparin binding growth factor receptor; HSFGFR3EX; Hydroxyaryl protein kinase; JTK 4; JTK4; MFR 3; SAM 3; Tyrosine kinase JTK 4; Tyrosine kinase JTK4; Z FGFR 3	Human	HEK293
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 Protein, Human (HEK293, hFc) is the recombinant human-derived FGFR-3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-3 Protein, Human (HEK293, hFc) is 353 a.a., with molecular weight of ~90 kDa.

HY-P72196

	FGFR-3 Protein, Human (His-B2M) ACH; CD 333; CD333; CD333 antigen; CEK 2; CEK2; FGFR 3; FGFR-3; FGFR3; FGFR3_HUMAN; Fibroblast growth factor receptor 3 achondroplasia thanatophoric dwarfism; ; Fibroblast growth factor receptor 3; Heparin binding growth factor receptor; HSFGFR3EX; Hydroxyaryl protein kinase; JTK 4; JTK4; MFR 3; SAM 3; Tyrosine kinase JTK 4; Tyrosine kinase JTK4; Z FGFR 3	Human	E. coli
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 Protein, Human (His-B2M) is the recombinant human-derived FGFR-3 protein, expressed by E. coli , with N-6*His, N-B2M labeled tag. The total length of FGFR-3 Protein, Human (His-B2M) is 410 a.a., with molecular weight of ~59.4 kDa.

HY-P76341

	FGFR-3 Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) Fibroblast growth factor receptor 3; FGFR-3; CD333; Mfr3; Sam3	Cynomolgus	HEK293
	FGFR-3 is a member of the fibroblast growth factor receptor family and is expressed in tissues such as cartilage, brain, intestine and kidney. FGFR-3 regulates chondrocyte differentiation and proliferation by activating the MAPK/STAT signaling pathway. FGFR-3 is a tumor marker. FGFR-3 Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is the recombinant cynomolgus-derived FGFR-3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-3 Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is 375 a.a., with molecular weight of ~99.9 KDa.

HY-P76342

FGFR-3 Protein, Cynomolgus/Rhesus Macaque (HEK293, His)

Fibroblast growth factor receptor 3; FGFR-3; CD333; Mfr3; Sam3
Rhesus Macaque HEK293
HY-P702760

FGFR-3 Protein, Human (sf9, His, Flag)

Fibroblast growth factor receptor 3; FGFR-3; CD333; JTK4
Human Sf9 insect cells
HY-P77662

FGFR-3 alpha (IIIb) Protein, Mouse (HEK293, His)

ACH; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4
Mouse HEK293

HY-P77655

	FGFR-3 alpha (IIIb) Protein, Human (HEK293, His-Avi) ACH; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4	Human	HEK293
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 alpha (IIIb) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-3 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-3 alpha (IIIb) Protein, Human (HEK293, His-Avi) is 355 a.a., with molecular weight of 65-75 kDa.

HY-P77657

	FGFR-3 beta (IIIb) Protein, Human (HEK293, His-Avi) ACH; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4	Human	HEK293
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 beta (IIIb) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-3 beta, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-3 beta (IIIb) Protein, Human (HEK293, His-Avi) is 249 a.a., with molecular weight of 40-55 kDa.

HY-P78439

	FGFR-3 alpha (IIIc) Protein, Human (HEK293, His-Avi) ACH; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4	Human	HEK293
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 alpha (IIIc) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-3 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-3 alpha (IIIc) Protein, Human (HEK293, His-Avi) is 353 a.a., with molecular weight of 65-75 kDa.

HY-P78440

	FGFR-3 beta (IIIc) Protein, Human (HEK293, His-Avi) ACH; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4	Human	HEK293
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 beta (IIIc) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-3 beta, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-3 beta (IIIc) Protein, Human (HEK293, His-Avi) is 251 a.a., with molecular weight of 50-60 kDa.

HY-P77656

	FGFR-3 alpha (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) ACH; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4	Human	HEK293
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 alpha (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-3 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-3 alpha (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) is 355 a.a., with molecular weight of 65-75 kDa.

HY-P77658

	FGFR-3 beta (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) ACH; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4	Human	HEK293
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 beta (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-3 beta, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-3 beta (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) is 249 a.a., with molecular weight of 40-55 kDa.

HY-P78124

	FGFR-3 alpha IIIc Protein, Human (Biotinylated, HEK293, His-Avi) ACH; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4	Human	HEK293
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 alpha IIIc Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-3 alpha IIIc protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-3 alpha IIIc Protein, Human (Biotinylated, HEK293, His-Avi) is 353 a.a., with molecular weight of 65-75 kDa.

HY-P78126

	FGFR-3 beta IIIc Protein, Human (Biotinylated, HEK293, His-Avi) ACH; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4	Human	HEK293
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 beta IIIc Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-3 beta IIIc protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-3 beta IIIc Protein, Human (Biotinylated, HEK293, His-Avi) is 251 a.a., with molecular weight of 50-60 kDa.

HY-P700484

	FGFR-3 Protein, Human (P. pastoris, N-His) Fibroblast growth factor receptor 3; FGFR-3; CD333; Mfr3; Sam3	Human	P. pastoris
	The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 Protein, Human (P. pastoris, N-His) is the recombinant human-derived FGFR-3 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of FGFR-3 Protein, Human (P. pastoris, N-His) is 410 a.a., with molecular weight of 47.4 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P80399

FGFR3 Antibody	WB, ICC/IF, IHC-P	Human, Mouse
FGFR3 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 88 kDa, targeting to FGFR3. It can be used for WB,ICC/IF,IHC-P assays with tag free, in the background of Human, Mouse.

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