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Results for "

FLAP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	FLAP (24) Apoptosis (4) Epoxide Hydrolase (4) Leukotriene Receptor (7) PPAR (2)
By Research Areas:	Cancer (9) Cardiovascular Disease (2) Inflammation/Immunology (16)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Targets Recommended: FLAP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122695

FEN1-IN-2 1 Publications Verification	FLAP	Cancer
FEN1-IN-2 (compound 20) is a flap endonuclease 1 (FEN1) inhibitor, with IC50 values of 3 nM and 226 nM for FEN1 and XPG, respectively .

HY-122908

Atuliflapon AZD5718	FLAP	Cardiovascular Disease
Atuliflapon (AZD5718) is an orally active inhibitor of FLAP (5‑Lipoxygenase activating protein), with an IC₅₀ of 2 nM. Atuliflapon is used in the study for coronary artery disease .

HY-156329

*sEH/FLAP-IN-1*	Epoxide Hydrolase FLAP	Inflammation/Immunology
sEH/FLAP-IN-1 (Compound 46A) is a *sEH/FLAP* inhibitor. sEH/FLAP-IN-1 inhibits 5-LOX product formation in SACM-stimulated PBMCs (EC₅₀: 11 nM). sEH/FLAP-IN-1 inhibit sEH (EC₅₀: 18 nM) and thromboxane production. sEH/FLAP-IN-1 can be used for research of inflammatory diseases .

HY-12995A

(S)-BI 665915	FLAP	Inflammation/Immunology
(S)-BI 665915 is an orally active oxadiazole-containing 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC₅₀ of 1.7 nM for FLAP binding. (S)-BI 665915 inhibits FLAP functional in human whole blood with an IC₅₀ of 45 nM. (S)-BI 665915 demonstrates an excellent cross-species agent metabolism and pharmacokinetics (DMPK) profile and a dose-dependent inhibition of LTB₄ production .

HY-155204

LTB4-IN-2	Leukotriene Receptor FLAP	Inflammation/Immunology
LTB4-IN-2 (Comopund 6x) is a Leukotriene B4 (LTB4) inhibitor. LTB4-IN-2 inhibits Leukotriene B4 formation (IC₅₀: 1.15 μM) by selectively targeting 5-Lipoxygenase-activating protein (FLAP). LTB4-IN-2 can be used for anti-inflammatory research .

HY-136485

FEN1-IN-4

FLAP Cancer

FEN1-IN-4 (Compound 2) is a human flap endonuclease-1 (hFEN1) inhibitor .
HY-136484

FEN1-IN-3

FLAP Cancer

FEN1-IN-3 (Compound 4) is a human flap endonuclease-1 (hFEN1) inhibitor. FEN1-IN-3 stabilizes hFEN1 with an EC₅₀ of 6.8 μM .

FEN1-IN-4	FLAP	Cancer
FEN1-IN-4 (Compound 2) is a human flap endonuclease-1 (hFEN1) inhibitor .

FEN1-IN-3	FLAP	Cancer
FEN1-IN-3 (Compound 4) is a human flap endonuclease-1 (hFEN1) inhibitor. FEN1-IN-3 stabilizes hFEN1 with an EC₅₀ of 6.8 μM .

HY-151619

sEH inhibitor-12	Epoxide Hydrolase	Inflammation/Immunology
sEH inhibitor-12 (compound 34) is a sEH inhibitor with an IC₅₀ value of 0.7 μM. sEH inhibitor-12 inhibits the 5-lipoxygenase-activating protein (FLAP)-mediated leukotriene (LT) biosynthesis with an IC₅₀ value of 2.9 μM. sEH inhibitor-12 can be used for the research of inflammation .

HY-15874

Fiboflapon GSK2190915; AM-803	FLAP Leukotriene Receptor	Inflammation/Immunology
Fiboflapon (GSK2190915; AM-803) is a potent and orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC₅₀ of 76 nM for inhibition of LTB4 in human blood .

HY-15874A

Fiboflapon sodium GSK2190915 sodium salt; AM-803 sodium	FLAP Leukotriene Receptor	Inflammation/Immunology
Fiboflapon sodium (GSK2190915; AM-803) is a potent and orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC₅₀ of 76 nM for inhibition of LTB4 in human blood .

HY-14163

AM103

FLAP Inflammation/Immunology

AM 103 is a potent and selective FLAP inhibitor, with an IC₅₀ value of 4.2 nM.

AM103	FLAP	Inflammation/Immunology
AM 103 is a potent and selective *FLAP* inhibitor, with an IC₅₀ value of 4.2 nM.

HY-14460

AM679	FLAP	Inflammation/Immunology
AM679 is a potent, selective 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC₅₀ of 2 nM in a human FLAP membrane binding assay. AM679 markedly reduces the respiratory syncytial virus-driven ocular pathology as well as the synthesis of cysteinyl leukotrienes (CysLTs) in the eye .

HY-10037

Quiflapon MK-591	FLAP Apoptosis	Inflammation/Immunology
Quiflapon (MK-591) is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC₅₀ of 1.6 nM in a FLAP binding assay. Quiflapon is also a potent and orally active Leukotriene biosynthesis (LT) inhibitor, shows IC₅₀ values of 3.1 and 6.1 nM in intact human and elicited rat PMNLs, respectively. Quiflapon induces cell apoptosis .

HY-50714

Quiflapon sodium MK-591 sodium	FLAP Apoptosis	Inflammation/Immunology
Quiflapon sodium (MK-591 sodium) is a selective and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor. Quiflapon sodium is an orally active Leukotriene biosynthesis inhibitor. Induces apoptosis.

HY-153790

FEN1-IN-5

FLAP Cancer

FEN1-IN-5 (compound 12A) is a potent inhibitor of Flap endonuclease-1 (FEN1, IC₅₀=12 nM), involving in DNA repair .

FEN1-IN-5	FLAP	Cancer
FEN1-IN-5 (compound 12A) is a potent inhibitor of *Flap* endonuclease-1 (FEN1, IC₅₀=12 nM), involving in DNA repair .

HY-14165

Veliflapon BAY X 1005; DG-031	FLAP Leukotriene Receptor	Cardiovascular Disease Inflammation/Immunology
Veliflapon (BAY X 1005; DG-031) is an orally active and selective 5-lipoxygenase activating protein (FLAP) inhibitor . Veliflapon inhibits the synthesis of the leukotrienes B4 and C4 .

HY-123834

FEN1-IN-1 4 Publications Verification	FLAP	Cancer
FEN1-IN-1 (compound 1) is a flap endonuclease 1 (FEN1) inhibitor. FEN1-IN-1 binds to the active site of FEN1 and partly achieves inhibition by the co-ordination of Mg ²⁺ ions .

HY-14166

MK-886 Maximum Cited Publications 7 Publications Verification L 663536	FLAP Leukotriene Receptor PPAR Apoptosis	Cancer
MK-886 (L 663536) is a potent, cell-permeable and orally active *FLAP* (IC₅₀ of 30 nM) and leukotriene biosynthesis (IC₅₀s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 is also a non-competitive PPARα antagonist and can induce apoptosis .

HY-153791

FEN1-IN-6	FLAP	Cancer
FEN1-IN-6 (compound 9) is a potent inhibitor of *Flap* endonuclease-1 (FEN1, IC₅₀=10 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-6 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC₅₀ value of 23 nM .

HY-14166A

MK-886 sodium salt L 663536 sodium salt	PPAR Apoptosis Leukotriene Receptor FLAP	Cancer
MK-886 (L 663536) sodium salt is a potent, cell-permeable and orally active *FLAP* (IC₅₀ of 30 nM) and leukotriene biosynthesis (IC₅₀s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 sodium salt is also a non-competitive PPARα antagonist and can induce apoptosis .

HY-155407

ALR-6	FLAP	Inflammation/Immunology
ALR-6 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-6 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM and has no significant effect on direct inhibition of 5-LOX .

HY-151617

sEH inhibitor-11	Epoxide Hydrolase	Inflammation/Immunology
sEH inhibitor-11 (compound 35) is a sEH inhibitor with an IC₅₀ value of 0.3 μM. sEH inhibitor-11 can be used for the research of inflammation .

HY-128171

Diflapolin 1 Publications Verification	FLAP Epoxide Hydrolase	Inflammation/Immunology
Diflapolin is a highly active dual 5-lipoxygenase-activating protein *(FLAP)*/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC₅₀s of 30 and 170 nM, respectively, and suppressed the activity of isolated sEH (IC₅₀=20 nM) .

HY-14165A

(S)-Veliflapon (S)-BAY X 1005; (S)-DG-031	Leukotriene Receptor FLAP	Inflammation/Immunology
(S)-Veliflapon ((S)-BAY X 1005) is an orally active inhibitor of leukotriene biosynthesis and 5-lipoxygenase activating protein (FLAP). (S)-Veliflapon inhibits the formation of leukotriene B4 (LTB4) in rat, mouse and human leukocytes with IC₅₀ values of 0.026 µM, 0.039 µM and 0.22 µM respectively. (S)-Veliflapon showes enantioselectivity in human whole blood .

HY-153792

FEN1-IN-7	FLAP	Cancer
FEN1-IN-7 (compound 16) is a selective inhibitor of *Flap* endonuclease-1 (FEN1, IC₅₀=18 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-7 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC₅₀ value of 3.04 μM. FEN1-IN-7 increases the cellular sensitivity of cancer cells to potent DNA alkylating agents or methylating agents .

HY-155408

ALR-27	FLAP	Inflammation/Immunology
ALR-27 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-27 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM, with no significant direct inhibition of 5-LOX. ALR-27 not only reduces prostaglandin and leukotriene (LT) production in neutrophils but also increases the production of specialized prolytic mediators in specific human macrophage phenotypes .

Species:	Human (3)
Tag:	SUMO (1) His (2) Tag Free (1) Myc (1)
Source:	E. coli Cell-free (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P70348

	Flap endonuclease 1/FEN-1 Protein, Human rHuFLAP endonuclease 1/FEN-1; FLAP Endonuclease 1; FEN-1; DNase IV; FLAP Structure-Specific Endonuclease 1; Maturation Factor 1; MF1; hFEN-1; FEN1; RAD2	Human	E. coli
	Flap endonuclease 1 (FEN-1) is a structure-specific nuclease crucial for DNA replication and repair. In replication, it cleaves 5'-overhanging flaps, guiding DNA polymerase and creating a nick for ligation. FEN-1 is integral to the long patch base excision repair pathway, preventing genomic instability. It exhibits 5'-3' exonuclease and RNase H activities, playing roles in rDNA and mitochondrial DNA replication and repair. Flap endonuclease 1/FEN-1 Protein, Human is the recombinant human-derived Flap endonuclease 1/FEN-1 protein, expressed by E. coli , with tag free. The total length of Flap endonuclease 1/FEN-1 Protein, Human is 380 a.a., with molecular weight of ~44.5 kDa.

HY-P700010

	Flap endonuclease 1/FEN-1 Protein, Human (His, Myc) rHuFLAP endonuclease 1/FEN-1; FLAP Endonuclease 1; FEN-1; DNase IV; FLAP Structure-Specific Endonuclease 1; Maturation Factor 1; MF1; hFEN-1; FEN1; RAD2	Human	E. coli
	Flap endonuclease 1 (FEN-1) is a structure-specific nuclease crucial for DNA replication and repair. In replication, it cleaves 5'-overhanging flaps, guiding DNA polymerase and creating a nick for ligation. FEN-1 is integral to the long patch base excision repair pathway, preventing genomic instability. It exhibits 5'-3' exonuclease and RNase H activities, playing roles in rDNA and mitochondrial DNA replication and repair. Flap endonuclease 1/FEN-1 Protein, Human (His, Myc) is the recombinant human-derived Flap endonuclease 1/FEN-1 protein, expressed by E. coli , with N-10*His, C-Myc labeled tag. The total length of Flap endonuclease 1/FEN-1 Protein, Human (His, Myc) is 380 a.a., with molecular weight of ~50.0 kDa.

HY-P702609

FLAP Protein, Human (Cell-Free, His-SUMO)

Arachidonate 5-lipoxygenase-activating protein; FLAP; ALOX5AP
Human E. coli Cell-free


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FEN1 Antibody (YA765) FEN1; RAD2; FLAP endonuclease 1; FEN-1; DNase IV; FLAP structure-specific endonuclease 1; Maturation factor 1; MF1; hFEN-1	WB, IP	Human, Mouse, Rat
FEN1 Antibody (YA765) is a non-conjugated and Mouse origined monoclonal antibody about 43 kDa, targeting to FEN1 (1E7). It can be used for WB,IP assays with tag free, in the background of Human, Mouse, Rat.

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