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FLT3-IN-12

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-143895
    FLT3-IN-12

    		FLT3 Cancer
    FLT3-IN-12 is a potent, selective and orally active FLT3 kinase inhibitor with IC50s of 1.48 nM and 2.87 nM for FLT3-WT and FLT3-D835Y, respectively. FLT3-IN-12 possesses high selectivity over c-KIT (>1000-fold). FLT3-IN-12 has an excellent anti-AML (acute myeloid leukemia) activity (MV4-11, IC50 of 0.75 nM) .
    <em>FLT3-IN-12</em>

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