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Results for "

FSP-1

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

1

Natural
Products

1

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-163002
    viFSP1

    		Ferroptosis Cancer
    viFSP1 is a species-independent inhibitor of FSP1 that induces ferroptosis in FSP1-dependent cells. viFSP1 targets the highly conserved NAD(P)H binding pocket of FSP1 and directly inhibits FSP1. viFSP1 induces lipid peroxidation and has anticancer activity [1].
    viFSP<em>1</em>
  • HY-157068
    icFSP1

    		Ferroptosis Cancer
    icFSP1 is a potent ferroptosis suppressor protein-1 (FSP1) inhibitor. icFSP1 does not competitively inhibit FSP1 enzyme activity, but instead triggers subcellular relocalization of FSP1 from the membrane and FSP1 condensation before ferroptosis induction, in synergism with GPX4 inhibition [1].
    icFSP<em>1</em>
  • HY-153629
    FSEN1

    		Ferroptosis Cancer
    FSEN1 is a potent and non-competitive FSP1 inhibitor with an IC50 value of 313 nM. FSEN1 triggers iron death in cancer cells by inhibiting FSP1. FSEN1 can be used in research of cancer [1].
    FSEN<em>1</em>
  • HY-136057
    iFSP1
    5+ Cited Publications

    		 Ferroptosis Cancer
    iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3 (HY-100218A) [1].
    iFSP<em>1</em>
  • HY-157744
    Coumarin–quinone conjugate

    		Others
    Coumarin–quinone conjugate is a fluorescent substrate for NADH:ubiquinone oxidoreductases which consists of a coumarin fluorophore and a ubiquinone analog. Coumarin–quinone conjugate can be used to measure the kinetic parameters of AIFM2/FSP1 for researches such as ferroptosis [1].
    Coumarin–quinone conjugate
  • HY-W015273A
    trans-3-Indoleacrylic acid

    		Endogenous Metabolite Ferroptosis Metabolic Disease Cancer
    Trans-3-Indoleacrylic acid is a tryptophan metabolite, which promotes tumor development through inhibition of RSL3 (HY-100218A) induced ferroptosis via AHR-ALDH1A3-FSP1-CoQ10 axis, and facilitates colorectal carcinogenesis [1]
    trans-3-Indoleacrylic acid
  • HY-101938
    Sinefungin
    1 Publications Verification

    Adenosyl-Ornithine; A-9145; Antibiotic 32232RP

    		 Histone Methyltransferase Fungal Antibiotic Parasite Infection Inflammation/Immunology
    Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication [1]. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation .
    Sinefungin

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