Factor-D

By Targets:	Complement System (11)
By Research Areas:	Inflammation/Immunology (11)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122700

Factor D inhibitor 6	Complement System	Inflammation/Immunology
Factor D inhibitor 6 is a potent, highly selective and orally active factor D (FD) inhibitor with an IC₅₀ of 30 nM and a K_d of 6 nM. Factor D inhibitor 6 is inactive against factor B, lassical and lectin complement-pathway activation, and a broad assay panel of receptors, ion channels, kinases and proteases .

HY-138281

*Complement factor D-IN-2*	Complement System	Inflammation/Immunology
Complement factor D-IN-2 is an inhibitor of complement factor D extracted from patent WO2015130838A1, compound 190. Complement factor D-IN-2 targets factor D and inhibits the complement cascade at an early and essential point in the alternative complement pathway. Complement factor D-IN-2 can be used for the research of autoimmune diseases .

HY-102034

*Complement factor D-IN-1*	Complement System	Inflammation/Immunology
Complement factor D-IN-1 is a potent and selective small-molecule reversible factor d inhibitor, with IC₅₀s of 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively.

HY-139588

Vemircopan

ALXN2050; ACH 0145228; ACH-5228
Complement System Inflammation/Immunology

Vemircopan (ALXN2050) is an orally active complement factor D inhibitor .

Vemircopan ALXN2050; ACH 0145228; ACH-5228	Complement System	Inflammation/Immunology
Vemircopan (ALXN2050) is an orally active complement factor D inhibitor .

HY-W049802

N-((Allyloxy)carbonyl)-N-methyl-L-alanine	Complement System	Inflammation/Immunology
N-((Allyloxy)carbonyl)-N-methyl-L-alanine is a Alanine derivative. N-((Allyloxy)carbonyl)-N-methyl-L-alanine can be used for the synthesis of inhibitors of complement factor D. Complement factor D inhibitors can be used in the research of immune system related disease .

HY-147297

Pelecopan BCX9930	Complement System	Inflammation/Immunology
Pelecopan (BCX9930) is a potent, selective, orally active inhibitor of complement factor D with an IC₅₀ value of 14.3 nM. Pelecopan can target factor D to prevent both intravascular and extravascular hemolysis in PNH. Pelecopan also be used for other alternative pathway (AP) mediated diseases .

HY-117930

Danicopan 3 Publications Verification ACH-4471	Complement System	Inflammation/Immunology
Danicopan (ACH-4471), a selective and orally active small-molecule *factor D* inhibitor, shows high binding affinity to human Factor D with K_d value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) .

HY-50874

BCX 1470	Complement System	Inflammation/Immunology
BCX 1470 inhibits the esterolytic activity of *factor D* (IC₅₀=96 nM) and C1s (IC₅₀=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.

HY-50875

BCX 1470 methanesulfonate	Complement System	Inflammation/Immunology
BCX 1470 methanesulfonate inhibits the esterolytic activity of *factor D* (IC₅₀=96 nM) and C1s (IC₅₀=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.

HY-P99298

Lampalizumab RG 7417; TNX 234; Anti-CFD Recombinant Antibody	Complement System	Inflammation/Immunology
Lampalizumab (RG 7417) is a humanised monoclonal antibody targeting complement *Factor D* in the alternative complement pathway. Lampalizumab binds an exosite and sterically blocks Factor B access to the active site. Lampalizumab can be used for age-related macular degeneration (AMD) research .

HY-128570

FD-IN-1	Complement System	Inflammation/Immunology
FD-IN-1 (Compound 12) is an orally bioavailable and selective *factor D* (FD) inhibitor with an IC₅₀ of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC₅₀s of 7.7 and 6.5 µM, respectively .

Cat. No.	Product Name	Type

HY-P2830

Complement factor D	Biochemical Assay Reagents
Complement factor D is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Cat. No.	Product Name	Target	Research Area

HY-P2830

Complement factor D

Peptides Others

Complement factor D is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Complement factor D	Peptides	Others
Complement factor D is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W049802

N-((Allyloxy)carbonyl)-N-methyl-L-alanine	Complement System	Inflammation/Immunology
N-((Allyloxy)carbonyl)-N-methyl-L-alanine is a Alanine derivative. N-((Allyloxy)carbonyl)-N-methyl-L-alanine can be used for the synthesis of inhibitors of complement factor D. Complement factor D inhibitors can be used in the research of immune system related disease .

Cat. No.	Product Name	Target	Research Area

HY-P99298

Lampalizumab RG 7417; TNX 234; Anti-CFD Recombinant Antibody	Complement System	Inflammation/Immunology
Lampalizumab (RG 7417) is a humanised monoclonal antibody targeting complement *Factor D* in the alternative complement pathway. Lampalizumab binds an exosite and sterically blocks Factor B access to the active site. Lampalizumab can be used for age-related macular degeneration (AMD) research .

Recombinant Proteins Recommended:

Factor D

Species:	Human (7) Rhesus Macaque (1) Mouse (6) Rat (2)
Tag:	His (8) SUMO (1) Tag Free (4) Fc (4)
Source:	HEK293 (10) CHO (2) P. pastoris (1) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P7861

	*Complement Factor D/Adipsin Protein, Human (HEK293, His)* rHuComplement Factor D/Adipsin, His; Complement Factor D; CFD; Adipsin; C3 convertase activator; Properdin Factor D; DF; PFD	Human	HEK293
	Complement factor D, also known as Adipsin, plays a crucial role in the alternative pathway of the complement system and when complexed with factor C3b, it cleaves factor B. This cleavage activates the C3bbb complex, converting it to the C3 convertase of the alternative pathway. Complement Factor D/Adipsin Protein, Human (HEK293, His) is the recombinant human-derived Complement Factor D/Adipsin protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Complement Factor D/Adipsin Protein, Human (HEK293, His) is 228 a.a., with molecular weight of ~28.0 kDa.

HY-P77898

	*Complement Factor D/Adipsin Protein, Rhesus macaque (HEK293, His)* Adipsin; C3 convertase activator; Complement Factor D; CFD; PFD; DF; ADN; Factor D; AMBP-1; EC 3.4.21; EC 3.4.21.46	Rhesus Macaque	HEK293
	Complement Factor D/Adipsin Protein is a member of the S1, or chymotrypsin, family of serine peptidases. Complement Factor D is expressed by adipose cells, plays an important role in both physiology and pathophysiology, where it plays a regulatory role in the complement system. Complement Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Complement Factor D/Adipsin Protein, Rhesus macaque (HEK293, His) is the recombinant Rhesus Macaque-derived Complement Factor D/Adipsin protein, expressed by HEK293 , with C-His labeled tag. The total length of Complement Factor D/Adipsin Protein, Rhesus macaque (HEK293, His) is 233 a.a., with molecular weight of 70-80 kDa.

HY-P78545

	*Complement Factor D/Adipsin Protein, Human (HEK293, Fc)* Adipsin; C3 convertase activator; Complement Factor D; CFD; PFD; DF; ADN; Factor D; AMBP-1; EC 3.4.21; EC 3.4.21.46	Human	HEK293
	Complement factor D, also known as Adipsin, plays a crucial role in the alternative pathway of the complement system and when complexed with factor C3b, it cleaves factor B. This cleavage activates the C3bbb complex, converting it to the C3 convertase of the alternative pathway. Complement Factor D/Adipsin Protein, Human (HEK293, Fc) is the recombinant human-derived Complement Factor D/Adipsin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Complement Factor D/Adipsin Protein, Human (HEK293, Fc) is 228 a.a., with molecular weight of 52-60 kDa.

HY-P78273

	*Complement Factor D/Adipsin Protein, Mouse (HEK293, Fc)* Adipsin; C3 convertase activator; Complement Factor D; CFD; PFD; DF; ADN; Factor D; AMBP-1; EC 3.4.21; EC 3.4.21.46	Mouse	HEK293
	Complement Factor D/Adipsin Protein cleaves factor B in complex with factor C3b, activating the C3bbb complex to form the C3 convertase in the alternate pathway, analogous to C1s in the classical pathway. Complement Factor D/Adipsin Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Complement Factor D/Adipsin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Complement Factor D/Adipsin Protein, Mouse (HEK293, Fc) is 234 a.a., with molecular weight of 60-70 kDa.

HY-P7861A

	*Complement Factor D/Adipsin Protein, Human (HEK293, His, Solution)* rHuComplement Factor D/Adipsin, His; Complement Factor D; CFD; Adipsin; C3 convertase activator; Properdin Factor D; DF; PFD	Human	HEK293
	Complement factor D, also known as Adipsin, plays a crucial role in the alternative pathway of the complement system and when complexed with factor C3b, it cleaves factor B. This cleavage activates the C3bbb complex, converting it to the C3 convertase of the alternative pathway. Complement Factor D/Adipsin Protein, Human (HEK293, His, Solution) is the recombinant human-derived Complement Factor D/Adipsin protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Complement Factor D/Adipsin Protein, Human (HEK293, His, Solution) is 228 a.a., with molecular weight of ~28.0 kDa.

HY-P7876

	*Complement Factor D/Adipsin Protein, Mouse (234a.a, HEK293, His)* rMuComplement Factor D/Adipsin, His; Complement Factor D; 28 kDa adipocyte protein; Adipsin; C3 convertase activator; Properdin Factor D; Cfd; Adn; Df	Mouse	HEK293
	Complement Factor D/Adipsin Protein cleaves factor B in complex with factor C3b, activating the C3bbb complex to form the C3 convertase in the alternate pathway, analogous to C1s in the classical pathway. Complement Factor D/Adipsin Protein, Mouse (234a.a, HEK293, His) is the recombinant mouse-derived Complement Factor D/Adipsin protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Complement Factor D/Adipsin Protein, Mouse (234a.a, HEK293, His) is 234 a.a., with molecular weight of 40-49 kDa.

HY-P71726

	*Complement Factor D/Adipsin Protein, Rat (P.pastoris, His)* Cfd; Adn; Df; Complement Factor D; EC 3.4.21.46; Adipsin; C3 convertase activator; Endogenous vascular elastase; Properdin Factor D	Rat	P. pastoris
	Complement Factor D/Adipsin Protein is pivotal, cleaving factor B within the factor C3b complex to activate the C3bbb complex, serving as the C3 convertase in the alternate pathway—analogous to C1s in the classical pathway. Complement Factor D/Adipsin Protein, Rat (P.pastoris, His) is the recombinant rat-derived Complement Factor D/Adipsin protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of Complement Factor D/Adipsin Protein, Rat (P.pastoris, His) is 238 a.a., with molecular weight (glycosylation form) of ~43 kDa.

HY-P7084

	LIF Protein, Mouse 3 Publications Verification rMuLIF; Differentiation-stimulating Factor; D Factor; MLPLI	Mouse	E. coli
	LIF Protein, Mouse is a lymphoid factor involved in various neural and inflammatory processes such as the acute-phase reaction, tissue damage, and infection.

HY-P7049

	LIF Protein, Human rHuLIF; Differentiation-stimulating Factor; D Factor; MLPLI	Human	E. coli
	LIF Protein, Human is a lymphoid factor involved in various neural and inflammatory processes such as the acute-phase reaction, tissue damage, and infection.

HY-P7280

	PDGF-DD Protein, Human (CHO) 1 Publications Verification rHuPDGF-DD; Platelet-derived growth Factor D; SCDGFB	Human	CHO
	PDGF-DD Protein, Human (CHO) is a member of the PDGF family, specifically binds to and activates its cognate receptor PDGFR-β, and participates in regulating cancer proliferation, transformation, and invasion through activating multiple downstream oncogenic pathways, resulting in tumor development and progression.

HY-P7314

	VEGF-D Protein, Human (HEK293) rHuVEGF-D; Vascular endothelial growth Factor D; FIGF	Human	CHO
	VEGF-D Protein, Human (HEK293) is a regulator of both angiogenesis and lymphangiogenesis.

HY-P72430

	VEGF-DD Protein, Mouse (HEK293, His) Vascular endothelial growth Factor D; VEGF-D; FIGF	Mouse	HEK293
	VEGF-DD Protein, a versatile growth factor, orchestrates angiogenesis, lymphangiogenesis, and endothelial cell growth. It stimulates proliferation, migration, and influences vessel permeability. VEGF-DD binds VEGFR-3, triggering crucial signaling for vascular development. Structurally, VEGF-DD is a non-covalent homodimer, emphasizing its intricate role in vascular processes. VEGF-DD Protein, Mouse (HEK293, His) is the recombinant mouse-derived VEGF-DD protein, expressed by HEK293 , with C-6*His labeled tag. The total length of VEGF-DD Protein, Mouse (HEK293, His) is 109 a.a., with molecular weight of 17-20 kDa.

HY-P73474

	VEGF-DD Protein, Mouse (HEK293, Fc) Vascular endothelial growth Factor D; VEGF-D; FIGF	Mouse	HEK293
	VEGF-DD Protein, a versatile growth factor, orchestrates angiogenesis, lymphangiogenesis, and endothelial cell growth. It stimulates proliferation, migration, and influences vessel permeability. VEGF-DD binds VEGFR-3, triggering crucial signaling for vascular development. Structurally, VEGF-DD is a non-covalent homodimer, emphasizing its intricate role in vascular processes. VEGF-DD Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived VEGF-DD protein, expressed by HEK293 , with N-hFc labeled tag. The total length of VEGF-DD Protein, Mouse (HEK293, Fc) is 109 a.a., with molecular weight of ~45 & 36 kDa, respectively.

HY-P73475

	VEGF-DD Protein, Rat (HEK293, Fc) Vascular endothelial growth Factor D; VEGF-D; FIGF	Rat	HEK293
	VEGF-DD, a growth factor, stimulates proliferation, migration, and vessel permeability. It is crucial for vascular development and maintenance of lymphatic endothelium. VEGF-DD binds and activates VEGFR-3, initiating essential signaling pathways. Structurally, it forms a non-covalent homodimer, playing an intricate role in vascular processes. VEGF-DD Protein, Rat (HEK293, Fc) is the recombinant rat-derived VEGF-DD protein, expressed by HEK293 , with N-hFc labeled tag. The total length of VEGF-DD Protein, Rat (HEK293, Fc) is 117 a.a., with molecular weight of ~50 kDa.

HY-P70495

	VEGF-DD Protein, Human (HEK293, His) Vascular Endothelial Growth Factor D; VEGF-D; c-Fos-Induced Growth Factor; FIGF; VEGFD	Human	HEK293
	VEGF-DD protein is a potent growth factor in angiogenesis, lymphangiogenesis, and endothelial cell growth, playing a key role in stimulating cell proliferation, migration, and affecting vascular permeability. It may be involved in the formation of veins and lymphatic vasculature during embryogenesis, suggesting that it plays a key role in vascular development. VEGF-DD Protein, Human (HEK293, His) is the recombinant human-derived VEGF-DD protein, expressed by HEK293 , with C-6*His labeled tag. The total length of VEGF-DD Protein, Human (HEK293, His) is 109 a.a., with molecular weight of ~18.0 kDa.

HY-P71615

	PDGF-DD Protein, Mouse (His-SUMO) Pdgfd; Scdgfb; Platelet-derived growth Factor D; PDGF-D; Spinal cord-derived growth Factor B; SCDGF-B	Mouse	E. coli
	PDGF-DD protein is an important growth factor that controls embryonic development, cell proliferation, migration, survival and chemotaxis, and has a potent mitogenic effect on mesenchymal cells. It plays a key role in wound healing and has carcinogenic potential, contributing to tumor formation. PDGF-DD Protein, Mouse (His-SUMO) is the recombinant mouse-derived PDGF-DD protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of PDGF-DD Protein, Mouse (His-SUMO) is 347 a.a., with molecular weight of ~66 kDa.


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HY-P83046

Factor D Antibody (YA2791)

DF; ADN; PFD; ADIPSIN
WB Human

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