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Farnesyl Transferase

" in MCE Product Catalog:

By Targets:	Farnesyl Transferase (14) Amino Acid Derivatives (1) Apoptosis (2) Autophagy (2) Microtubule/Tubulin (1) NOD-like Receptor (NLR) (1) Ras (3)
By Research Areas:	Cancer (14) Infection (4) Inflammation/Immunology (1)

15

Inhibitors & Agonists

1

Peptides

1

Natural
Products

Targets Recommended: Farnesyl Transferase Gutathione S-transferase NAMPT

Cat. No.	Product Name	Target	Research Areas

FGTI-2734 mesylate	Farnesyl Transferase	Cancer
FGTI-2734 mesylate is a RAS C-terminal mimetic dual farnesyl transferase (FT) and *geranylgeranyl transferase-1 (GGT)* inhibitor with IC₅₀s of 250 nM and 520 nM for FT and GGT, respectively. FGTI-2734 mesylate can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors.

FGTI-2734	Farnesyl Transferase	Cancer
FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and *geranylgeranyl transferase-1 (GGT-1)* inhibitor with IC₅₀s of 250 nM and 520 nM for FT and GGT-1, respectively. FGTI-2734 can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors.

Tubulin polymerization-IN-25	Microtubule/Tubulin Farnesyl Transferase	Cancer
Tubulin polymerization-IN-25 (compound 17f) is a dual inhibitor of tubulin polymerization and **farnesyl transferase (FTase) with IC₅₀**s of 1.11 μM and 0.39 μM, respectively. Tubulin polymerization-IN-25 displays cytotoxicity and excellent antitumor activity .

HY-16111

BMS-214662
Farnesyl Transferase Cancer

BMS-214662 is a potent and selective farnesyl transferase inhibitor with potent antitumor activity with an IC₅₀ of 1.35 nM.
HY-15873

FTI 276
Farnesyl Transferase Cancer

FTI-276 is a protein farnesyl transferase (PFT) inhibitor with IC₅₀s of 0.9 and 0.5 nM for Plasmodium falciparum and human.

FTI-2148	Farnesyl Transferase	Cancer
FTI-2148 is a RAS C-terminal mimetic dual farnesyl transferase (FT-1) and *geranylgeranyl transferase-1 (GGT-1)* inhibitor with IC₅₀s of 1.4 nM and 1.7 μM, respectively.

FTI-2148 diTFA	Farnesyl Transferase	Cancer
FTI-2148 diTFA is a RAS C-terminal mimetic dual farnesyl transferase (FT-1) and *geranylgeranyl transferase-1 (GGT-1)* inhibitor with IC₅₀s of 1.4 nM and 1.7 μM, respectively.

HY-15873A

FTI 276 TFA
Farnesyl Transferase Cancer

FTI-276 is a protein farnesyl transferase (PFT) inhibitor with IC₅₀s of 0.9 nM and 0.5 nM for Plasmodium falciparum and human, respectively.

H-Met-OiPr hydrochloride	Amino Acid Derivatives	Others
H-Met-OiPr hydrochloride is an Methionine derivative. H-Met-OiPr hydrochloride participates in the synthesis preparation of inhibitors of farnesyl-protein transferase (FTase), and can be used in cancer research.

Ftase inhibitor I B581	Farnesyl Transferase	Cancer
Ftase inhibitor I (B581) is a potent, selective and peptidomimetic farnesyl transferase (FTase) inhibitor. Ftase inhibitor I shows selectivity for FTase over geranylgeranyl isoprenoid (Ras-GG) or the fatty acid myristate (Myr-Ras).

FTI-277 hydrochloride	Farnesyl Transferase Apoptosis Ras	Cancer Infection
FTI-277 hydrochloride is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 hydrochloride can inhibit hepatitis delta virus (HDV) infection.

FTI-277	Farnesyl Transferase Apoptosis Ras	Cancer Infection
FTI-277 is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 can inhibit hepatitis delta virus (HDV) infection.

Arglabin (+)-Arglabin	NOD-like Receptor (NLR) Farnesyl Transferase Autophagy	Cancer Inflammation/Immunology
Arglabin ((+)-Arglabin), a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor. Arglabin shows anti-inflammatory and antitumor activities. The antitumor activity of Arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene.

Lonafarnib Sch66336	Farnesyl Transferase Ras Autophagy	Cancer Infection
Lonafarnib (Sch66336) is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC₅₀ values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities.

(Rac)-Lonafarnib Sch66336 racemate	Farnesyl Transferase	Cancer Infection
(Rac)-Lonafarnib (Sch66336 racemate) is the racemate of Lonafarnib. Lonafarnib is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC₅₀ values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities.

Cat. No.	Product Name	Target	Research Area

H-Met-OiPr hydrochloride	Amino Acid Derivatives	Others
H-Met-OiPr hydrochloride is an Methionine derivative. H-Met-OiPr hydrochloride participates in the synthesis preparation of inhibitors of farnesyl-protein transferase (FTase), and can be used in cancer research.

Cat. No.	Product Name	Target	Category

Arglabin (+)-Arglabin	NOD-like Receptor (NLR) Farnesyl Transferase Autophagy	Sesquiterpenes Terpenoids Structural Classification Compositae Apios americana Medik. Plants Source classification Inflammation/Immunology Disease Research Fields Classification of Application Fields
Arglabin ((+)-Arglabin), a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor. Arglabin shows anti-inflammatory and antitumor activities. The antitumor activity of Arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene.

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