Search Result

Results for "

Folate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (2) Antibiotic (11) Antibody-Drug Conjugates (ADCs) (3) Antifolate (13) Bacterial (12) Dihydrofolate reductase (DHFR) (2) DNA/RNA Synthesis (1) Drug Metabolite (1) Drug-Linker Conjugates for ADC (1) Endogenous Metabolite (12) Fluorescent Dye (2) Influenza Virus (3) Isotope-Labeled Compounds (4) Liposome (11) Methylenetetrahydrofolate Dehydrogenase (MTHFD) (1) Parasite (8) PROTAC Linkers (7) PROTACs (1) PSMA (1) Reactive Oxygen Species (4) SHMT (1) Thymidylate Synthase (4)
By Research Areas:	Cancer (44) Infection (15) Inflammation/Immunology (6) Metabolic Disease (6) Neurological Disease (2)
Click Chemistry:	DBCO (1) PROTAC Synthesis (2) Azide (1) Alkynes (5)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-47373

Folate-PEG3-C2-acid	PROTAC Linkers	Cancer
Folate-PEG3-C2-acid is the acid fragment of Folate-PEG3-NHS ester (HY-133493), which belongs to the PEG-type PROTAC linker and is used to synthesize PROTAC molecules.

HY-115873

Folate-MS432

PROTACs Cancer

Folate-MS432, a PROTAC, is capable of degrading MEKs in a folate receptor-dependent manner in cancer cells.

Folate-MS432	PROTACs	Cancer
Folate-MS432, a PROTAC, is capable of degrading MEKs in a folate receptor-dependent manner in cancer cells.

HY-133496

Folate-PEG3-alkyne	PROTAC Linkers	Cancer
Folate-PEG3-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Folate-PEG3-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-133494

Folate-PEG1-mal

PROTAC Linkers Cancer

Folate-PEG1-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
HY-133495

Folate-PEG2-amine

PROTAC Linkers Cancer

Folate-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
HY-133493

Folate-PEG3-NHS ester

PROTAC Linkers Cancer

Folate-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
HY-138484

Folate-PEG3-amine

ADC Linker Cancer

Folate-PEG3-amine is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

Folate-PEG1-mal	PROTAC Linkers	Cancer
Folate-PEG1-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

Folate-PEG2-amine	PROTAC Linkers	Cancer
Folate-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

Folate-PEG3-NHS ester	PROTAC Linkers	Cancer
Folate-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

Folate-PEG3-amine	ADC Linker	Cancer
Folate-PEG3-amine is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-133483

Folate-PEG3-azide	PROTAC Linkers	Cancer
Folate-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Folate-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-133383

DSPE-PEG46-Folate

PROTAC Linkers Cancer

DSPE-PEG46-Folate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

DSPE-PEG46-Folate	PROTAC Linkers	Cancer
DSPE-PEG46-Folate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-144009

*DSPE-PEG-Folate, MW 3350*	Liposome	Cancer
DSPE-PEG-Folate, MW 3350 is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folate receptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research .

HY-W440888

*DSPE-PEG-Folate, MW 2000*	Liposome	Others
DSPE-PEG-Folate, MW 2000 is a PEG derivative containing folic acid. DSPE-PEG-Folate, MW 2000 has a targeting effect and bind to folate receptors in cancer cells. DSPE-PEG-Folate, MW 2000 form micelles/lipid bilayer and can be used to targeted drug delivery system research.

HY-W440890

*DSPE-PEG-Folate, MW 5000*	Liposome	Cancer
DSPE-PEG-Folate, MW 5000 is a PEG derivative containing folic acid. DSPE-PEG-Folate, MW 5000 has a targeting effect and bind to folate receptors in cancer cells. DSPE-PEG-Folate, MW 5000 form micelles/lipid bilayer and can be used to targeted drug delivery system research .

HY-W440715

Cholesterol-PEG-Folate, MW 2000

Liposome Others

Cholesterol-PEG-Folate, MW 2000 is an excipient and can be used for the preparation of folate-conjugated PEG-liposomes .

*Cholesterol-PEG-Folate, MW 2000*	Liposome	Others
Cholesterol-PEG-Folate, MW 2000 is an excipient and can be used for the preparation of folate-conjugated PEG-liposomes .

HY-127118

Pteropterin Pteroyltriglutamic	Others	Cancer
Pteropterin (Pteroyltriglutamic) is an active form of folate. Pteropterin shows inhibiting effect on tumor growth and has broad anticancer activity .

HY-127118A

Pteropterin monohydrate Pteroyltriglutamic monohydrate	Others	Cancer
Pteropterin (Pteroyltriglutamic) monohydrate is an active form of folate. Pteropterin monohydrate shows inhibiting effect on tumor growth and has broad anticancer activity .

HY-W037823

Pterin-6-carboxylic acid	Others	Others
Pterin-6-carboxylic acid serves as a precursor for the formation of folate, which plays a critical role in cell growth, development, and repair. Pterine-6-carboxylic acid has been studied for its potential as a fluorescent dye .

HY-10822A

ONX 0801 trisodium BGC 945 trisodium; Idetrexed trisodium; CB 300945 trisodium	Thymidylate Synthase	Cancer
ONX 0801 (BGC 945) trisodium is a thymidylate synthase (TS) inhibitor, targeted to α-folate receptor–overexpressing tumors .

HY-137267

10-Methyl-10-deazaaminopterin	Antifolate	Cancer
10-Methyl-10-deazaaminopterin is a folate analog and an antifolate. 10-Methyl-10-deazaaminopterin can be used for the research of cancer .

HY-109051C

Arfolitixorin sulfate	Endogenous Metabolite	Cancer
Arfolitixorin sulfate is a potent 5-Fluorouracil (5-FU) moderator. Arfolitixorin sulfate is an immediately active form of Folate, [6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF). Arfolitixorin sulfate is potent for the research of metastatic colorectal cancer .

HY-13728

Plevitrexed ZD 9331; BGC9331	Thymidylate Synthase	Cancer
Plevitrexed (ZD 9331; BGC 9331) is an orally active and potent thymidylate synthase (TS) inhibitor with a K_i of 0.44 nM. Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is used for gastric cancer in clinical . Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-147699

FRα-IN-1	Antifolate	Cancer
FRα-IN-1 (Compound 4) is a tumor-targeting agent. FRα-IN-1 shows selective anticancer activity towards folate receptors (FRα and FRβ) expression cells .

HY-108251

Methotrexate metabolite 1 Publications Verification DAMPA	Antifolate Drug Metabolite Dihydrofolate reductase (DHFR) Parasite	Infection Inflammation/Immunology
Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent . Methotrexate metabolite is an antimalarial agent, which inhibits the parasite growth with an IC₅₀ of 446 nM against the antifolate-sensitive strain and 812 nM against the highly resistant strain under physiological folate conditions. Methotrexate metabolite is inactive against mammalian cells. Methotrexate metabolite is a minimal inhibitor of dihydrofolate reductase among metabolites of methotrexate .

HY-W040821

DL-Homocysteine 2 Publications Verification	Endogenous Metabolite	Neurological Disease
DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain. DL-Homocysteine is correlated with Vitamin B12, renal functions and folate levels, affects the cross-sectional cognition indirectly through white matter microstructural integrity .

HY-B1497

Silver sulfadiazine AgSD	Bacterial DNA/RNA Synthesis Antibiotic	Infection
Silver sulfadiazine (AgSD), a sulfonamide antibiotic, effects a dual inhibitory action on bacterial growth by its sulfa moiety (SD-SDZ) that prevents bacterial folate absorption and subsequent DNA synthesis. The silver that is released from Silver sulfadiazine binds and disrupts the DNA structure, precluding bacterial DNA replication .

HY-P99153

Farletuzumab MORAb-003	Antibiotic	Cancer
Farletuzumab (MORAb-003) is a potent folate receptor-alpha (FRα) inhibitor. Farletuzumab is a humanized monoclonal antibody with high affinity for FRα. Farletuzumab possesses growth-inhibitory functions on cells overexpressing FRα. Farletuzumab can be used in research of cancer .

HY-10824

Talotrexin PT523	Antifolate Dihydrofolate reductase (DHFR)	Cancer
Talotrexin (PT523), an analog of Aminopterin (HY-14518), is a nonpolyglutamatable classic antifolate. Talotrexin is a *RFC (reduced folate* carrier) specific inhibitor and selectively inhibits RFC transport. Talotrexin shows antitumor activity by targeting DHFR** to inhibit tumor growth .

HY-14520

Tetrahydrofolic acid 1 Publications Verification L-5,6,7,8-Tetrahydrofolic acid; L-Tetrahydrofolic acid	Endogenous Metabolite	Metabolic Disease
Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid .

HY-P99612

Farletuzumab ecteribulin MORAb-202	Antibody-Drug Conjugates (ADCs)	Cancer
Farletuzumab ecteribulin (MORAb-202) is an antibody-drug conjugate (ADC), consisting of the humanized anti-human folate receptor alpha (FRA) antibody Farletuzumab (HY-P99153) conjugated via reduced interchain disulfide bonds to Mal-PEG2-Val-Cit-PAB-eribulin. Farletuzumab ecteribulin has a agent-to-antibody ratio of 4.0. Farletuzumab ecteribulin is highly cytotoxic to FRA-positive cells in vitro. Farletuzumab ecteribulin has potent antitumor activity.

HY-155880

mPEG-amine (MW 350) mPEG-NH2 (MW 350)	Liposome	Cancer
mPEG-amine (MW 350) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-155881

mPEG-amine (MW 550) mPEG-NH2 (MW 550)	Liposome	Cancer
mPEG-amine (MW 550) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-155882

mPEG-amine (MW 750) mPEG-NH2 (MW 750)	Liposome	Cancer
mPEG-amine (MW 750) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-155883

mPEG-amine (MW 3400) mPEG-NH2 (MW 3400)	Liposome	Cancer
mPEG-amine (MW 3400) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-17383

Levomefolate calcium

1 Publications Verification

Antifolate Cancer

Levomefolate calcium is an artificial form of folate.

Levomefolate calcium 1 Publications Verification	Antifolate	Cancer
Levomefolate calcium is an artificial form of folate.

HY-155884

mPEG-amine (MW 4000) mPEG-NH2 (MW 4000)	Liposome	Cancer
mPEG-amine (MW 4000) can be used to synthesize folate-conjugated polymer micelles for encapsulating anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-113046

5-Methyltetrahydrofolic acid 5 Publications Verification 5-Methyl THF	Endogenous Metabolite	Metabolic Disease
5-Methyltetrahydrofolic acid (5-Methyl THF) is a biologically active form of folic acid. 5-Methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. 5-Methyltetrahydrofolic acid is the predominant natural dietary folate and the principal form of folate in plasma and cerebrospinal fluid .

HY-137129

10-Formyl-7,8-dihydrofolic acid	Endogenous Metabolite	Metabolic Disease
10-Formyl-7,8-dihydrofolic acid is a substrate for mammalian aminoimidazolecarboxamide ribotide transformylase (EC 2.1.2.3). 10-Formyl-7,8-dihydrofolic acid also is a metabolite of 10-HCO-H4folate .

HY-P99225

Mirvetuximab M9346A	Antifolate	Cancer
Mirvetuximab (M9346A) is an anti-FOLR1 (folate receptor 1) monoclonal antibody. Mirvetuximab is the antibody moiety of novel folate receptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). Mirvetuximab soravtansine can be used in ovarian and other FRα-positive cancer research .

HY-128939

EC0488

Antifolate Cancer

EC0488 is used to synthesize EC0531 with folate receptor (FR)-specific and anti-tumor activities .
HY-128940

EC089

ADC Linker Cancer

EC089 is a cleavable linker used in conjugates of tubulysins and folates, and extracted from patent WO2011069116A1 .

EC0488	Antifolate	Cancer
EC0488 is used to synthesize EC0531 with folate receptor (FR)-specific and anti-tumor activities .

EC089	ADC Linker	Cancer
EC089 is a cleavable linker used in conjugates of tubulysins and folates, and extracted from patent WO2011069116A1 .

HY-113046S

5-Methyltetrahydrofolic acid-13C5 5-Methyl THF-¹³C₅	Endogenous Metabolite	Metabolic Disease
5-Methyltetrahydrofolic acid- ¹³C₅ is the ¹³C-labeled 5-Methyltetrahydrofolic acid. 5-Methyltetrahydrofolic acid (5-Methyl THF) is a biologically active form of folic acid. 5-Methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. 5-Methyltetrahydrofolic acid is the predominant natural dietary folate and the principal form of folate in plasma and cerebrospinal fluid[1].

HY-W115607

PEG-bis-amine (MW 8000) Poly(ethylene glycol)-bis-amine (MW 8000)	Liposome	Cancer
PEG-bis-amine (MW 8000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-W591632

PEG-bis-amine (MW 1000) Poly(ethylene glycol)-bis-amine (MW 1000)	Liposome	Cancer
PEG-bis-amine (MW 1000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-17383S

Levomefolate-13C5 calcium	Isotope-Labeled Compounds Antifolate	Cancer
Levomefolate- ¹³C₅ (calcium) is the ¹³C-labeled Levomefolate (calcium). Levomefolate calcium is an artificial form of folate.

HY-135101

Methotrexate γ-Methyl Ester Methotrexate 5-methyl ester; γ-EMTX	Others	Others
Methotrexate γ-Methyl Ester (Methotrexate 5-methyl ester) is an impurity of the folate antagonist Methotrexate (HY-14519) .

HY-163196

PSMA-IN-4

PSMA Others

PSMA-IN-4 (compound 9) is a potent inhibitor of PSMA, with the IC₅₀ value of 1.2 μM .

PSMA-IN-4	PSMA	Others
PSMA-IN-4 (compound 9) is a potent inhibitor of PSMA, with the IC₅₀ value of 1.2 μM .

HY-W007692

Acetylpyrazine 2-Acetylpyrazine	Others	Others
Acetylpyrazine (2-Acetylpyrazine) is used to form many polycyclic compounds, as useful structures in pharmaceuticals and perfumes. Acetylpyrazine is a component of the folates (vitamin B compounds) .

HY-B1008S

4-Aminobenzoic acid-d4 PABA-d₄; Vitamin Bx-d₄; Vitamin H1-d₄; p-Aminobenzoic acid-d₄	Isotope-Labeled Compounds Endogenous Metabolite	Others
4-Aminobenzoic acid-d₄ is the deuterium labeled 4-Aminobenzoic acid. 4-Aminobenzoic acid is an intermediate in the synthesis of folate by bacteria, plants, and fungi.

HY-B1008S1

4-Aminobenzoic acid-13C6 PABA-¹³C₆; Vitamin Bx-¹³C₆; Vitamin H1-¹³C₆; p-Aminobenzoic acid-¹³C₆	Endogenous Metabolite	Others
4-Aminobenzoic acid- ¹³C₆ is the ¹³C-labeled 4-Aminobenzoic acid. 4-Aminobenzoic acid is an intermediate in the synthesis of folate by bacteria, plants, and fungi.

HY-114306

EC0489	Antifolate	Cancer
EC0489, a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor . Small molecule-agent conjugate (SMDC) .

HY-101943

LY 345899 4 Publications Verification	Methylenetetrahydrofolate Dehydrogenase (MTHFD)	Cancer
LY 345899 is a Folate analog and is a methylene tetrahydrofolate dehydrogenase (MTHFD1; DC301) and MTHFD2 inbhibitor with IC₅₀ values of 96 nM and 663 nM, respectively and a K_i of 18 nM for MTHFD1 .

Cat. No.	Product Name	Type

HY-144009

*DSPE-PEG-Folate, MW 3350*	Drug Delivery
DSPE-PEG-Folate, MW 3350 is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folate receptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research .

HY-W440888

*DSPE-PEG-Folate, MW 2000*	Drug Delivery
DSPE-PEG-Folate, MW 2000 is a PEG derivative containing folic acid. DSPE-PEG-Folate, MW 2000 has a targeting effect and bind to folate receptors in cancer cells. DSPE-PEG-Folate, MW 2000 form micelles/lipid bilayer and can be used to targeted drug delivery system research.

HY-W440890

*DSPE-PEG-Folate, MW 5000*	Drug Delivery
DSPE-PEG-Folate, MW 5000 is a PEG derivative containing folic acid. DSPE-PEG-Folate, MW 5000 has a targeting effect and bind to folate receptors in cancer cells. DSPE-PEG-Folate, MW 5000 form micelles/lipid bilayer and can be used to targeted drug delivery system research .

HY-W440715

Cholesterol-PEG-Folate, MW 2000

Drug Delivery

Cholesterol-PEG-Folate, MW 2000 is an excipient and can be used for the preparation of folate-conjugated PEG-liposomes .

HY-155880

mPEG-amine (MW 350) mPEG-NH2 (MW 350)	Drug Delivery
mPEG-amine (MW 350) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-155881

mPEG-amine (MW 550) mPEG-NH2 (MW 550)	Drug Delivery
mPEG-amine (MW 550) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-155882

mPEG-amine (MW 750) mPEG-NH2 (MW 750)	Drug Delivery
mPEG-amine (MW 750) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-155883

mPEG-amine (MW 3400) mPEG-NH2 (MW 3400)	Drug Delivery
mPEG-amine (MW 3400) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-155884

mPEG-amine (MW 4000) mPEG-NH2 (MW 4000)	Drug Delivery
mPEG-amine (MW 4000) can be used to synthesize folate-conjugated polymer micelles for encapsulating anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-W115607

PEG-bis-amine (MW 8000) Poly(ethylene glycol)-bis-amine (MW 8000)	Drug Delivery
PEG-bis-amine (MW 8000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-W591632

PEG-bis-amine (MW 1000) Poly(ethylene glycol)-bis-amine (MW 1000)	Drug Delivery
PEG-bis-amine (MW 1000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W040821

DL-Homocysteine 2 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Cardiovascular System Disorder	Endogenous Metabolite
DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain. DL-Homocysteine is correlated with Vitamin B12, renal functions and folate levels, affects the cross-sectional cognition indirectly through white matter microstructural integrity .

HY-14520

Tetrahydrofolic acid 1 Publications Verification L-5,6,7,8-Tetrahydrofolic acid; L-Tetrahydrofolic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid .

HY-113046

5-Methyltetrahydrofolic acid 5 Publications Verification 5-Methyl THF	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
5-Methyltetrahydrofolic acid (5-Methyl THF) is a biologically active form of folic acid. 5-Methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. 5-Methyltetrahydrofolic acid is the predominant natural dietary folate and the principal form of folate in plasma and cerebrospinal fluid .

HY-109051C

Arfolitixorin sulfate	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Arfolitixorin sulfate is a potent 5-Fluorouracil (5-FU) moderator. Arfolitixorin sulfate is an immediately active form of Folate, [6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF). Arfolitixorin sulfate is potent for the research of metastatic colorectal cancer .

HY-137129

10-Formyl-7,8-dihydrofolic acid	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
10-Formyl-7,8-dihydrofolic acid is a substrate for mammalian aminoimidazolecarboxamide ribotide transformylase (EC 2.1.2.3). 10-Formyl-7,8-dihydrofolic acid also is a metabolite of 10-HCO-H4folate .

HY-14520A

(6S)-Tetrahydrofolic acid (6S)-5,6,7,8-Tetrahydrofolic acid; (6S)-Tetrahydrofolic acid	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite
(6S)-Tetrahydrofolic acid is 1000-fold more active than the (6R) form at promoting the binding of fluorodeoxyuridylate to thymidylate synthase and 600-fold more active as a growth factor of P. cerevisiae. (6S)-Tetrahydrofolic acid also has a low affinity and high dissociation rate for folate-binding protein .

HY-14769

Folitixorin 1 Publications Verification 5,10-MethylenetetraFolate; ANX-510 free acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Folitixorin (5,10-methylenetetrahydrofolate) is a cofactor and an analog of leucovorin. Folitixorin is a promising agent for modulation of 5-FU cytotoxicity in adjuvant cancer research .

Species:	Human (11) Mouse (4) Rat (2) Cynomolgus (1) Canine (2)
Tag:	His (18) Strep (1) Avi (1) MBP (1) Fc (2) Flag (2)
Source:	HEK293 (18) Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P70344

	FOLR1 Protein, Mouse (HEK293, His) rMuFolate receptor alpha/FOLR1, His; Adult Folate-binding protein; FBP; Folate binding protein; Folate receptor 1 (adult); Folate receptor 1; Folate receptor alpha; Folate receptor, adult; Folbp1; FOLR; FOLR1; FR-alpha; KB cells FBP; MOv18; Ovarian tumor-associated antigen MOv18	Mouse	HEK293
	FOLR1 Protein, binding to folate and reduced folic acid derivatives, facilitates their delivery into cells. It maintains high affinity under neutral pH but undergoes a conformational change upon endocytosis, reducing affinity and releasing folates in slightly acidic pH. Crucial for embryonic development, cell proliferation, and renal folate reabsorption. FOLR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FOLR1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FOLR1 Protein, Mouse (HEK293, His) is 208 a.a., with molecular weight of 33-37 kDa.

HY-P76348

	FOLR2 Protein, Human (HEK293, His) Folate receptor beta; FR-beta; Placental Folate-binding protein; FBP	Human	HEK293
	FOLR2 Protein binds folate, enabling the transport of 5-methyltetrahydrofolate into cells with high affinity under neutral pH. Upon endocytosis, exposure to slightly acidic pH induces a conformational change, substantially reducing FOLR2's folate affinity and releasing it from the receptor. FOLR2 Protein, Human (HEK293, His) is the recombinant human-derived FOLR2 protein, expressed by HEK293 , with C-His labeled tag. The total length of FOLR2 Protein, Human (HEK293, His) is 212 a.a., with molecular weight of 28-35 KDa.

HY-P70296

	FOLR1 Protein, Human (210a.a, HEK293, His) rHuFolate receptor alpha/FOLR1, His; Folate receptor alpha; FR-alpha; Adult Folate-binding protein; FBP; Folate receptor 1; Folate receptor; Ovarian tumor-associated antigen MOv18; FOLR1	Human	HEK293
	The FOLR1 protein is an important mediator of folate uptake, binding to folate and promoting the delivery of 5-methyltetrahydrofolate into cells. Studies show high affinity at neutral pH. FOLR1 Protein, Human (210a.a, HEK293, His) is the recombinant human-derived FOLR1 protein, expressed by HEK293 , with C-His labeled tag. The total length of FOLR1 Protein, Human (210a.a, HEK293, His) is 210 a.a., with molecular weight of 34-38 kDa.

HY-P72371

	FOLR1 Protein, Human (Biotinylated, HEK293, His-Avi) Folate receptor alpha; FR-alpha; Adult Folate-binding protein; FBP; Folate receptor 1; Folate receptor	Human	HEK293
	The FOLR1 protein is an important mediator of folate uptake, binding to folate and promoting the delivery of 5-methyltetrahydrofolate into cells. Studies show high affinity at neutral pH. FOLR1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FOLR1 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of FOLR1 Protein, Human (Biotinylated, HEK293, His-Avi) is 210 a.a., with molecular weight of 35-40 kDa.

HY-P78766

	FOLR3 Protein, Human (HEK293, His) Folate receptor 3 (gamma); Folate receptor 3; Folate receptor gamma; FOLR3; FR-G; FR-gamma; gamma-Hfr;	Human	HEK293
	FOLR3 protein is crucial in folate metabolism, binding to folate and aiding 5-methyltetrahydrofolate delivery into cells. Notably, the Isoform Short of FOLR3 lacks folate-binding capabilities, indicating diverse functional roles among FOLR3 isoforms. This highlights nuanced regulation in cellular folate transport processes. FOLR3 Protein, Human (HEK293, His) is the recombinant human-derived FOLR3 protein, expressed by HEK293, with C-His labeled tag. The total length of FOLR3 Protein, Human (HEK293, His) is 223 a.a., with molecular weight of 33-45 kDa.

HY-P75775

	FOLR1 Protein, Rat (HEK293, Fc) Folate receptor alpha; FR-alpha; FBP; FOLR1; FOLR	Rat	HEK293
	The FOLR1 protein is a member of the folate receptor family. Folate receptors are cell surface proteins that bind folate (vitamin B9) and transport it into cells. FOLR1 Protein, Rat (HEK293, Fc) is the recombinant rat-derived FOLR1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FOLR1 Protein, Rat (HEK293, Fc) is 212 a.a., with molecular weight of ~50.9 kDa.

HY-P75776

	FOLR1 Protein, Rat (HEK293, His) Folate receptor alpha; FR-alpha; FBP; FOLR1; FOLR	Rat	HEK293
	FOLR1 is a member of the folate receptor family. FOLR1 Protein, Rat (HEK293, His) is the recombinant rat-derived FOLR1 protein, expressed by HEK293, with C-His labeled tag. The total length of FOLR1 Protein, Rat (HEK293, His) is 207 a.a., with molecular weight of ~25.7 kDa.

HY-P76936

	FOLR1 Protein, Canine (HEK293, Fc) Folate receptor alpha; FR-alpha; FBP; FOLR1; FOLR	Canine	HEK293
	FOLR1 is a folic acid receptor that binds to folic acid and reductive folic acid derivatives and promotes the entry of 5-methyltetrahydrofolate and folate analogs into the cell interior. FOLR1 enhances the stability and nuclear translocation of β-catenin through the EGFR/AKT/GSK3β axis, thereby promoting the proliferation and migration of laryngeal squamous cell carcinoma (LSCC). FOLR1 is highly expressed in a variety of tumors and is a potential prognostic and therapeutic target for many cancers. FOLR1 Protein, Canine (HEK293, Fc) is the recombinant canine-derived FOLR1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FOLR1 Protein, Canine (HEK293, Fc) is 204 a.a., with molecular weight of ~50.7 KDa.

HY-P76937

	FOLR1 Protein, Canine (HEK293, His) Folate receptor alpha; FR-alpha; FBP; FOLR1; FOLR	Canine	HEK293
	FOLR1 is a folic acid receptor that binds to folic acid and reductive folic acid derivatives and promotes the entry of 5-methyltetrahydrofolate and folate analogs into the cell interior. FOLR1 enhances the stability and nuclear translocation of β-catenin through the EGFR/AKT/GSK3β axis, thereby promoting the proliferation and migration of laryngeal squamous cell carcinoma (LSCC). FOLR1 is highly expressed in a variety of tumors and is a potential prognostic and therapeutic target for many cancers. FOLR1 Protein, Canine (HEK293, His) is the recombinant canine-derived FOLR1 protein, expressed by HEK293 , with C-His labeled tag. The total length of FOLR1 Protein, Canine (HEK293, His) is 204 a.a., with molecular weight of ~25.4 KDa.

HY-P75774

	FOLR1 Protein, Human (209a.a, HEK293, His) Folate receptor alpha; FR-alpha; FBP; FOLR1; FOLR	Human	HEK293
	FOLR1 protein is a vital mediator in folate uptake, binding to folate and facilitating the delivery of 5-methyltetrahydrofolate into cells. Studies show high affinity at neutral pH. Upon endocytosis, exposure to a slightly acidic pH induces a conformational change, reducing folate affinity and facilitating release. Beyond folate transport, FOLR1 is crucial for embryonic development and cell proliferation, emphasizing its role in fundamental cellular processes. FOLR1 Protein, Human (209a.a, HEK293, His) is the recombinant human-derived FOLR1 protein, expressed by HEK293, with C-10*His labeled tag. The total length of FOLR1 Protein, Human (209a.a, HEK293, His) is 209 a.a., with molecular weight of ~37.45 kDa.

HY-P77936

	FOLR4 Protein, Human (HEK293, His) Folate receptor 4; FR-delta; Izumo1r; Folbp3; Juno; FOLR4, LOC390243	Human	HEK293
	The FOLR4 protein serves as a receptor for IZUMO1 on the egg membrane and plays a crucial role in species-specific gamete recognition and fertilization. The interaction between IZUMO1 and FOLR4 (IZUMO1R/JUNO) is an important adhesion event that is required for fertilization but not sufficient for cell fusion. FOLR4 Protein, Human (HEK293, His) is the recombinant human-derived FOLR4 protein, expressed by HEK293 , with C-His labeled tag. The total length of FOLR4 Protein, Human (HEK293, His) is 209 a.a., with molecular weight of 30-35 kDa.

HY-P77938

	FOLR4 Protein, Mouse (HEK293, His) Folate receptor 4; FR-delta; Izumo1r; Folbp3; Juno; FOLR4, LOC390243	Mouse	HEK293
	FOLR4 is a receptor on the egg membrane that interacts with IZUMO1 and is essential for species-specific gamete recognition and fertilization. Although it is essential for fertilization, it is not sufficient by itself to achieve cell fusion. FOLR4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FOLR4 protein, expressed by HEK293 , with C-His labeled tag. The total length of FOLR4 Protein, Mouse (HEK293, His) is 203 a.a., with molecular weight of 35-40 kDa.

HY-P70548

	PSMA Protein, Human (HEK293, His) Glutamate carboxypeptidase 2; FGCP; GCPII; mGCP; NAALADase I; PSMA; Cell growth-inhibiting gene 27 protein; Folate hydrolase 1	Human	HEK293
	PSMA protein, with a preference for tri-alpha-glutamate peptides, acts as a folate hydrolase and NAALADase enzyme. It uptakes folate in the intestines, modulates excitatory neurotransmission by hydrolyzing NAAG to release glutamate in the brain, and exhibits dipeptidyl-peptidase IV type activity by cleaving Gly-Pro-AMC in vitro. PSMA Protein, Human (HEK293, His) is the recombinant human-derived PSMA protein, expressed by HEK293 , with N-6*His labeled tag. The total length of PSMA Protein, Human (HEK293, His) is 707 a.a., with molecular weight of 90-120 kDa.

HY-P71240

	PSMA Protein, Mouse (HEK293, His) Glutamate carboxypeptidase 2; FGCP; GCPII; mGCP; NAALADase I; PSMA; Cell growth-inhibiting gene 27 protein; Folate hydrolase 1	Mouse	HEK293
	PSMA Protein, a multifunctional enzyme, acts as a folate hydrolase and NAALADase with a preference for tri-alpha-glutamate peptides. In the intestine, it aids folate uptake for metabolic processes. In the brain, PSMA modulates neurotransmission by hydrolyzing NAAG, releasing glutamate. It also shows dipeptidyl-peptidase IV type activity and effectively cleaves Gly-Pro-AMC, highlighting its versatile enzymatic functions. PSMA Protein, Mouse (HEK293, His) is the recombinant mouse-derived PSMA protein, expressed by HEK293 , with N-6*His labeled tag. The total length of PSMA Protein, Mouse (HEK293, His) is 709 a.a., with molecular weight of 100-120 kDa.

HY-P76703

	PSMA Protein, Human (Biotinylated, HEK293, His) Glutamate carboxypeptidase 2; FGCP; GCPII; mGCP; NAALADase I; PSMA; Cell growth-inhibiting gene 27 protein; Folate hydrolase 1	Human	HEK293
	PSMA protein, with a preference for tri-alpha-glutamate peptides, acts as a folate hydrolase and NAALADase enzyme. It uptakes folate in the intestines, modulates excitatory neurotransmission by hydrolyzing NAAG to release glutamate in the brain, and exhibits dipeptidyl-peptidase IV type activity by cleaving Gly-Pro-AMC in vitro. PSMA Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived PSMA protein, expressed by HEK293 , with N-6*His labeled tag. The total length of PSMA Protein, Human (Biotinylated, HEK293, His) is 707 a.a., with molecular weight of ~81.7 kDa.

HY-P70548A

	PSMA Protein, Human (HEK293, N-His) Glutamate carboxypeptidase 2; FGCP; GCPII; mGCP; NAALADase I; PSMA; Cell growth-inhibiting gene 27 protein; Folate hydrolase 1	Human	HEK293
	PSMA protein, with a preference for tri-alpha-glutamate peptides, acts as a folate hydrolase and NAALADase enzyme. It uptakes folate in the intestines, modulates excitatory neurotransmission by hydrolyzing NAAG to release glutamate in the brain, and exhibits dipeptidyl-peptidase IV type activity by cleaving Gly-Pro-AMC in vitro. PSMA Protein, Human (HEK293, N-His) is the recombinant human-derived PSMA protein, expressed by HEK293 , with N-6*His labeled tag. The total length of PSMA Protein, Human (HEK293, N-His) is 707 a.a., with molecular weight of 80-120 kDa.

HY-P78026

	PSMA Protein, Cynomolgus (HEK293, His) GCP2; PSMA; PSMAFGCP; FGCP; Folate hydrolase 1; FOLHNAALADase I; GCPII; GCPIImGCP; NAALAD1; NAALADase I; NAALAdase; FOLH1; GIG27; PSM; FOLH; mGCP	Cynomolgus	HEK293
	PSMA Protein, a vital peptidase M28 family member in the M28B subfamily, plays a significant role as a peptidase enzyme involved in peptide bond hydrolysis. PSMA likely shares conserved features with related proteins, emphasizing its role in cellular processes related to peptide metabolism. The M28B subfamily designation highlights its specific classification within the broader peptidase M28 family. Studying PSMA provides insights into its distinct enzymatic functions and potential applications in therapeutic interventions, deepening our comprehension of its impact on biological pathways. Further exploration promises to enhance our knowledge of PSMA's contributions to normal physiology and pathological conditions. PSMA Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived PSMA protein, expressed by HEK293, with N-His labeled tag. The total length of PSMA Protein, Cynomolgus (HEK293, His) is 707 a.a., with molecular weight of 90-110 kDa.

HY-P700006

	PSMA Protein, Mouse (Biotinylated, HEK293, His) GCP2; PSMA; PSMAFGCP; FGCP; Folate hydrolase 1; FOLHNAALADase I; GCPII; GCPIImGCP; NAALAD1; NAALADase I; NAALAdase; FOLH1; GIG27; PSM; FOLH; mGCP	Mouse	HEK293
	The PSMA protein is a multifunctional enzyme with folate hydrolase and NAALADase activities and a preference for tri-alpha-glutamic acid peptides. It absorbs folate in the intestines, aids in important metabolic processes, and modulates excitatory neurotransmission in the brain by hydrolyzing NAAG to release glutamate. PSMA Protein, Mouse (Biotinylated, HEK293, His) is the recombinant mouse-derived PSMA protein, expressed by HEK293 , with N-His labeled tag. The total length of PSMA Protein, Mouse (Biotinylated, HEK293, His) is 708 a.a., with molecular weight of 90-110 kDa.

HY-P702007

	SLC19A1 Protein, Human (Sf9, His, Strep, FLAG) SLC19A1; Reduced Folate transporter; FOLT; Intestinal Folate carrier 1; IFC-1; Placental Folate transporter; Reduced Folate carrier protein; RFC; hRFC; Reduced Folate transporter 1; RFT-1; Solute carrier family 19 member 1; hSLC19A1	Human	Sf9 insect cells
	The SLC19A1 protein acts as an antiporter, importing reduced folate and cyclic dinucleotides by exporting organic anions. It acts as a secondary active transporter, exporting intracellular organic anions to facilitate substrate uptake. SLC19A1 Protein, Human (Sf9, His, Strep, FLAG) is the recombinant human-derived SLC19A1 protein, expressed by Sf9 insect cells , with N-Strep, C-Flag, N-8*His labeled tag. The total length of SLC19A1 Protein, Human (Sf9, His, Strep, FLAG) is 590 a.a., .

HY-P702023

	SLC46A1 Protein, Human (Sf9, His, MBP, FLAG) SLC46A1; Proton-coupled Folate transporter; G21; Heme carrier protein 1; PCFT/HCP1; Solute carrier family 46 member 1	Human	Sf9 insect cells
	The SLC46A1 protein is a proton-coupled folate symporter that utilizes the H(+) gradient in the proximal jejunum to drive folate absorption. It transports folate from the blood to the cerebrospinal fluid and exhibits alternating outward- and inward-open conformational states at acidic pH. SLC46A1 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC46A1 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC46A1 Protein, Human (Sf9, His, MBP, FLAG) is 458 a.a., .

Cat. No.	Product Name	Chemical Structure

HY-113046S

5-Methyltetrahydrofolic acid-13C5
5-Methyltetrahydrofolic acid- ¹³C₅ is the ¹³C-labeled 5-Methyltetrahydrofolic acid. 5-Methyltetrahydrofolic acid (5-Methyl THF) is a biologically active form of folic acid. 5-Methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. 5-Methyltetrahydrofolic acid is the predominant natural dietary folate and the principal form of folate in plasma and cerebrospinal fluid[1].

HY-B1008S

4-Aminobenzoic acid-d4
4-Aminobenzoic acid-d₄ is the deuterium labeled 4-Aminobenzoic acid. 4-Aminobenzoic acid is an intermediate in the synthesis of folate by bacteria, plants, and fungi.

HY-17383S

Levomefolate-13C5 calcium

Levomefolate- ¹³C₅ (calcium) is the ¹³C-labeled Levomefolate (calcium). Levomefolate calcium is an artificial form of folate.

HY-B1008S1

4-Aminobenzoic acid-13C6
4-Aminobenzoic acid- ¹³C₆ is the ¹³C-labeled 4-Aminobenzoic acid. 4-Aminobenzoic acid is an intermediate in the synthesis of folate by bacteria, plants, and fungi.

HY-14520S

Tetrahydrofolic acid-d4

Tetrahydrofolic acid-d₄ is the deuterium labeled Tetrahydrofolic acid. Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid[1][2].

HY-B0688S

Dapsone-d8

Dapsone-d₈ is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].

HY-B0688S1

Dapsone-d4

Dapsone-d₄ is the deuterium labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[2][3].

HY-B0688S2

Dapsone-13C12

Dapsone- ¹³C₁₂ is the ¹³C₁₂ labeled Dapsone (HY-B0688). Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .

Cat. No.	Product Name		Classification

HY-133483

Folate-PEG3-azide		PROTAC Synthesis Azide
Folate-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Folate-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-13728

Plevitrexed ZD 9331; BGC9331		Alkynes
Plevitrexed (ZD 9331; BGC 9331) is an orally active and potent thymidylate synthase (TS) inhibitor with a K_i of 0.44 nM. Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is used for gastric cancer in clinical . Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-133496

Folate-PEG3-alkyne		Alkynes PROTAC Synthesis
Folate-PEG3-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Folate-PEG3-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10822A

ONX 0801 trisodium BGC 945 trisodium; Idetrexed trisodium; CB 300945 trisodium		Alkynes
ONX 0801 (BGC 945) trisodium is a thymidylate synthase (TS) inhibitor, targeted to α-folate receptor–overexpressing tumors .

HY-10822

Idetrexed BGC 945; ONX-0801		Alkynes
Idetrexed is a thymidylate synthase inhibitor specifically transported into alpha-folate receptor (alpha-FR)-overexpressing tumors. BGC 945 inhibited thymidylate synthase with a K_i of 1.2 nmol/L .

HY-W006064

(S)-2-Aminopent-4-ynoic acid		Alkynes
(S)-2-Aminopent-4-ynoic acid is a synthetic amino acid. (S)-2-Aminopent-4-ynoic acid can be used in synthesis of folate-conjugates and corresponding metal-chelate complexes . (S)-2-Aminopent-4-ynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-148194

SC239		DBCO
SC239 is a cleavable 2-aminophenyl hemiasterlin agent-linker. SC239 can be as the agent-linker for ADC . SC239 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

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