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Results for "

FtsZ

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (2) Bacterial (20) Fatty Acid Synthase (FASN) (1) PARP (1)
By Research Areas:	Cancer (3) Infection (19)

20

Inhibitors & Agonists

1

Natural
Products

1

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

FtsZ-IN-5	Bacterial	Infection
FtsZ-IN-5 is a potent *FtsZ* inhibitor, to promote FtsZ polymerization and inhibit GTPase activity of FtsZ. Thus, FtsZ-IN-5 inhibits bacterial division to lead to death of bacterial cells. FtsZ-IN-5 shows bactericidal activity with no significant tendency to trigger bacterial resistance as well as rapid bactericidal properties. And FtsZ-IN-5 shows low hemolytic activity and cytotoxicity to mammalian cells .

FtsZ-IN-6	Bacterial	Infection
FtsZ-IN-6 is a potent *FtsZ* inhibitor, to promote FtsZ polymerization and inhibit GTPase activity of FtsZ. Thus, FtsZ-IN-6 inhibits bacterial division to lead to death of bacterial cells. FtsZ-IN-6 shows bactericidal activity with no significant tendency to trigger bacterial resistance as well as rapid bactericidal properties. And FtsZ-IN-6 shows low hemolytic activity and cytotoxicity to mammalian cells .

FtsZ-IN-7	Bacterial	Infection
FtsZ-IN-7 is a potent *FtsZ* inhibitor, to promote FtsZ polymerization and inhibit GTPase activity of FtsZ. Thus, FtsZ-IN-7 inhibits bacterial division to lead to death of bacterial cells. FtsZ-IN-7 shows bactericidal activity with no significant tendency to trigger bacterial resistance as well as rapid bactericidal properties. And FtsZ-IN-7 shows low hemolytic activity and cytotoxicity to mammalian cells .

FtsZ-IN-8	Bacterial	Infection
FtsZ-IN-8 is a potent *FtsZ* inhibitor, to promote FtsZ polymerization and inhibit GTPase activity of FtsZ. Thus, FtsZ-IN-8 inhibits bacterial division to lead to death of bacterial cells. FtsZ-IN-8 shows bactericidal activity with no significant tendency to trigger bacterial resistance as well as rapid bactericidal properties. And FtsZ-IN-8 shows low hemolytic activity and cytotoxicity to mammalian cells .

FtsZ-IN-1	Bacterial	Infection
FtsZ-IN-1 is a potent *FtsZ* inhibitor with quinolinium ring. FtsZ-IN-1 has stronger antibacterial activity against Gram-positive bacteria with MICs of 0.5-8 μg/mL. FtsZ-IN-1 significantly causes cell elongation of B. subtilis by enhancing FtsZ polymerization. FtsZ-IN-1 exhibits low hemolytic toxicity and low tendency to induce agent resistance. FtsZ-IN-1 has against drug-resistant bacteria activity .

HY-161148

FtsZ-IN-9

Bacterial Infection

FtsZ-IN-9 (compound 11) is an antimicrobial agent. FtsZ-IN-9 inhibits the assembly of Mycobacterium smegmatis FtsZ (MsFtsZ)_[1].

FtsZ-IN-2	Bacterial	Infection
FtsZ-IN-2 (Compound 19) is an inhibitor of the bacterial cell division protein *FtsZ* with GTPase inhibitory activity. FtsZ-IN-2 exhibits anti-staphylococcal activity with MIC values of 2 µg/ml for MSSA and MRSA .

FtsZ-IN-4	Bacterial	Infection
FtsZ-IN-4 is an orally active *FtsZ* (filamenting temperature-sensitive mutant Z) inhibitor, exhibits excellent antibacterial activity. FtsZ-IN-4 shows good pharmaceutical properties with low cytotoxicity (CC₅₀ >20 μg/mL) .

HY-N2567

(±)-Decursinol

Bacterial Infection Cancer

(±)-Decursinol is a potent FtsZ inhibitor. (±)-Decursinol inhibits B. anthracis FtsZ polymerization with an IC₅₀ of 102 μM .

TXA6101	Bacterial	Infection
TXA6101 is a bacterial protein *FtsZ* (filamentous temperature-sensitive protein Z) inhibitor that inhibits bacterial division. TXA6101 has antimicrobial activity against MRSA isolates expressing either the G193D or G196S mutant FtsZ with the MIC value of 1 μg/mL, retains significant activity against the TXA707-resistant FtsZ mutant. TXA6101 can be used as a potential method against Gram-negative bacterial infections .

UCM53	Bacterial	Infection
UCM53, a *FtsZ* inhibitor, is an antibacterial agent. UCM53 can inhibit the growth of clinical isolates of antibiotic-resistant Staphylococcus aureus and Enterococcus faecalis

HY-123711

PC170942

Bacterial Infection

PC170942, a PC58538 analogue, is a potent FtsZ protein inhibitor. PC170942 is a cell division inhibitor, and shows antibacterial activities .

8-Br-GTP 8-Bromoguanosine-5'-triphosphate	Bacterial	Infection
8-Br-GTP, a GTP analog, is a competitive FtsZ polymerization and GTPase activity (K_i of 31.8 μM) inhibitor. 8-Br-GTP can be used for nucleic acid modification .

Antibacterial agent 185	Bacterial	Infection
Antibacterial agent 185 (compound IP-01) is a potent antibacterial agent. Antibacterial agent 185 inhibits filamentous temperature-sensitive mutant Z (FtsZ) polymerization and bundling by increasing GTP hydrolysis. Antibacterial agent 185 inhibits Streptococcus pneumoniae and shows narrow-spectrum activity .

CCR-11	Bacterial	Infection
CCR-11 is an antibacterial agent. CCR-11 can inhibit the proliferation of B. subtilis cells with an IC₅₀ value of 1.2 μM. CCR-11 inhibits HeLa cell proliferation with an IC₅₀ value of 18.1 μM. CCR-11 inhibits bacterial cytokinesis by inhibiting FtsZ assembly. CCR-11 can be used for the research of FtsZ-targeted antibacterial agents .

MA220607	Bacterial	Infection
MA220607 is an antibacterial agent with low hemolytic toxicity and a dual-target mechanism of action (MOA). MA220607 promotes FtsZ protein polymerization, also increases the permeability of bacterial membranes and inhibits biofilm formation. The resistance rate of MA220607 is low, and the MICs against Gram-positive bacteria and Gram-negative bacteria are Table 0.062-2 μg/mL and 0.5-4 μg/mL, respectively) .

PC190723	Bacterial Antibiotic	Infection
PC190723 (Compound 2) is an inhibitor of the bacterial cell division protein *FtsZ* with an IC₅₀ of 55 ng/ml. FtsZ-IN-3 exhibits anti-staphylococcal activity with MIC values of 1 µg/ml for MSSA and MRSA .

UCM05 G28UCM	Fatty Acid Synthase (FASN) Bacterial Antibiotic	Infection Cancer
UCM05 (G28UCM) is a potent inhibitor of fatty acid synthase (FASN) shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. UCM05 is a Filamentous temperature-sensitive protein Z (FtsZ) inhibitor and inhibits the growth of the Gram-positive bacterium B. subtilis with MIC values of 100 μM but lack activity on the Gram-negative bacterium E. coli.

3-Methoxybenzamide 3-MBA	PARP Bacterial	Cancer
3-Methoxybenzamide (3-MBA), an inhibitor of ADP-ribosyltransferase (ADPRTs) and PARP, inhibits cell division in Bacillus subtilis, leading to filamentation and eventually lysis of cells . 3-Methoxybenzamide (3-MBA) enhances in vitro plant growth, microtuberization, and transformation efficiency of blue potato (Solanum tuberosum L. subsp. andigenum) .

PC58538	Bacterial	Infection
PC58538 is a cell division inhibitor, targeting to *FtsZ. PC58538 shows moderate antibacterial activity, and inhibits cell division in vegetative cells of wild-type B. subtilis*. PC58538 is also known to modulate the rate of GTP hydrolysis .

Cat. No.	Compare	Product Name	Species	Source

	FtsZ Protein, E.coli (His-SUMO) FtsZ; c0113Cell division protein FtsZ	E.coli	E. coli
	FtsZ is an essential cell division protein that plays a central role in coordinating the formation of the contractile Z ring at the site of expected cell division. Precise regulation of the components of this ring is a key determinant, affecting the timing and location of cell division. FtsZ Protein, E.coli (His-SUMO) is the recombinant E. coli-derived FtsZ protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of FtsZ Protein, E.coli (His-SUMO) is 383 a.a., with molecular weight of ~56.3 kDa.

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