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Results for "

Fungal

" in MCE Product Catalog:

251

Inhibitors & Agonists

3

Screening Libraries

2

Fluorescent Dye

6

Peptides

2

MCE Kits

131

Natural
Products

19

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas
  • HY-125705
    Herquline A

    Herqueline A

    Influenza Virus Infection Cardiovascular Disease
    Herquline A (Herqueline A) is a fungal piperazine alkaloid. Herquline A is a fungal metabolite that inhibits platelet aggregation and replication of the influenza virus.
  • HY-111238
    Butyrolactone II

    Endogenous Metabolite Infection
    Butyrolactone II is a fungal metabolite isolated from Aspergillus flavipes.
  • HY-N6217
    F-14329

    Endogenous Metabolite Others
    F-14329 is a tetramic acid fungal metabolite.
  • HY-119697
    Setosusin

    (+)-Setosusin

    Endogenous Metabolite Others
    Setosusin ((+)-Setosusin) is a fungal meroditerpenoid featuring a unique spiro-fused 3(2H)-furanone moiety.
  • HY-P1703
    Avellanin B

    Endogenous Metabolite Others
    Avellanin B is a fungal metabolite with pressor effect.
  • HY-113816
    Radicinin

    Others Others
    Radicinin, a fungal phytotoxin, is a target-specific bioherbicide for Invasive Buffelgrass (Cenchrus ciliaris) control.
  • HY-N10186
    Dibefurin

    Phosphatase Endogenous Metabolite Others
    Dibefurin is a fungal metabolite that acts as an inhibitor of calcineurin phosphatase.
  • HY-125684
    Trichodecenin I

    Endogenous Metabolite Others
    Trichodecenin I, a fungal metabolite, is a peptaibol composed of 7 amino acid residues.
  • HY-N8548
    Fellutanine A

    Endogenous Metabolite Infection
    Fellutanine A, a diketopiperazine alkaloid, is a fungal metabolite from cultures of Penicillium fellutanum.
  • HY-N10238
    Mycestericin G

    Endogenous Metabolite Inflammation/Immunology
    Mycestericin G is a sphingosine-like fungal metabolite that exhibits immunosuppressive activity.
  • HY-N8331
    Terpendole I

    Acyltransferase Endogenous Metabolite Cancer
    Terpendole I, a fungal indoloditerpene, is a ACAT (acyl-CoA: cholesterol acyltransferase) inhibitor (IC50=145 µM).
  • HY-125344
    Fusarisetin A

    Endogenous Metabolite Infection
    Fusarisetin A, a pentacyclic fungal metabolite, is an acinar morphogenesis inhibitor.
  • HY-124551
    Viridiol

    Fungal Antibiotic Infection
    Viridiol, a fungal metabolite from Trichodernza viride, shows antifungal activity.
  • HY-118427
    Asterriquinol D dimethyl ether

    Parasite Endogenous Metabolite Cancer Infection
    Asterriquinol D dimethyl ether is a fungal metabolite, which can inhibit mouse myeloma NS-1 cell lines with an IC50 of 28 μg/mL. Asterriquinol D dimethyl ether also inhibits Tritrichomonas foetus.
  • HY-N10234
    Phenylpyropene A

    Acyltransferase Infection
    Phenylpyropene A, a fungal metabolite, is a potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor with an IC50 of 0.8 μM.
  • HY-N4283A
    (E)-Coniferyl alcohol

    Fungal Infection
    (E)-Coniferyl alcohol is the isomer of Coniferyl alcohol. Coniferyl alcohol is an intermediate in biosynthesis of eugenol and of stilbenoids and coumarin. Coniferyl alcohol specifically inhibits fungal growth.
  • HY-N10270
    Verrucofortine

    Others Others
    Verrucofortine, a fungal metabolite, is an alkaloid derived from tryptophan and leucine.
  • HY-N10220
    Paraherquamide E

    Endogenous Metabolite Parasite Infection
    Paraherquamide E is a fungal metabolite found in Penicillium charlesii. Paraherquamide E has antinematodal and antiparasitic effects.
  • HY-148071
    Epocholeone

    Others Others
    Epocholeone is a growth regulator. Epocholeone can control fungal or physiological diseases of crops.
  • HY-121133
    (-)-Cyclopenol

    Others Others
    (-)-Cyclopenol is a fungal metabolite isolated from an Australian marine-derived isolate of Aspergillus versicolor (MST-MF495) .
  • HY-125411
    Berninamycin D

    Others Others
    Berninamycin D is a cyclic peptide fungal metabolite isolated from ermentation of Streptomyces bernensis.
  • HY-136767
    Cladosporin

    Fungal Antibiotic Infection
    Cladosporin is a fungal metabolite produced in good yield in the mycelium of Cladosporium cladosporioid. Cladosporin completely inhibits growth of severa dermatophytes on agar medium at a concentration of 75 μg/mL.
  • HY-W145584
    D-Iditol

    Endogenous Metabolite Cancer Metabolic Disease
    D-Iditol is a fungal metabolite, a sugar alcohol that accumulates in galactokinase deficiency. D-Iditol may have potential antitumour activity.
  • HY-N8396
    Cerebroside C

    Endogenous Metabolite Infection
    Cerebroside C, a sphingolipid, is a fungal metabolite. Cerebroside C licits defense responses in rice.
  • HY-125060
    Viridicatin

    Antibiotic Endogenous Metabolite Infection
    Viridicatin is a fungal metabolite from Penicillium species. Viridicatin shows slight in vitro antibiotic activity against Mycobacterium tuberculosis.
  • HY-135154
    epi-Aszonalenin A

    GABA Receptor Neurological Disease
    epi-Aszonalenin A is a benzodiazepine fungal metabolite originally isolated from Aspergillus novofumigatus. epi-Aszonalenin A can be used as a psychoactive agent.
  • HY-121004
    Bikaverin

    Lycopersin

    Fungal Antibiotic Infection
    Bikaverin (Lycopersin) is a reddish pigment produced by different fungal species. Bikaverin shows antibiotic properties against certain protozoa and fungi.
  • HY-N8349
    19,20-Epoxycytochalasin D

    Parasite Endogenous Metabolite Cancer Infection
    19,20-Epoxycytochalasin D, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin D shows potent in vitro antiplasmodial activity and phytotoxicity.
  • HY-N8385
    19,20-Epoxycytochalasin C

    Parasite Endogenous Metabolite Cancer Infection
    19,20-Epoxycytochalasin C, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin C shows potent in vitro antiplasmodial activity and phytotoxicity.
  • HY-B0843
    Metalaxyl

    Fungal Infection
    Metalaxyl is a fungicide that inhibits protein synthesis in fungi. Metalaxyl inhibits the growth of potato blight (P. infestans) fungal isolates from Serbian potato fields (EC50s=0.3-3.9 μg/mL).
  • HY-17006A
    Caspofungin

    MK-0991; L-743872

    Antibiotic Fungal Bacterial Infection
    Caspofungin is a potent antifungal agent. Caspofungin inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan.
  • HY-N10194
    P-orlandin

    Parasite Endogenous Metabolite Infection
    P-orlandin, a fungal metabolite, prevents FREP1 from binding to gametocytes or ookinetes. P-orlandin effectively inhibits P. falciparum infection in mosquitoes.
  • HY-N8105
    Protoneogracillin

    Fungal Cancer Infection
    Protoneogracillin, a furostanol glycoside, shows anti-fungal activity against the plant pathogenic fungus P.oryzae (MMDC=94.0 μM) and cytotoxic activity on K562 cancer cells (IC50=6.6 μM).
  • HY-N10228
    Gliorosein

    Others Infection
    Gliorosein is a fungal metabolite isolated from Gliocladium. Gliorosein is isomeric with the quinol but shows a different ultraviolet absorption spectrum.
  • HY-17006
    Caspofungin diacetate

    MK-0991 diacetate; L-743872 diacetate

    Fungal Antibiotic Bacterial Infection Cancer
    Caspofungin (MK-0991) diacetate is a potent antifungal agent. Caspofungin diacetate inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan.
  • HY-151420
    Chitin synthase inhibitor 10

    Fungal Cancer Infection
    Chitin synthase inhibitor 10 is a chitin synthase (CHS) inhibitor. Chitin synthase inhibitor 10 shows excellent CHS inhibitory activity with an IC50 value of 0.11 mM. Chitin synthase inhibitor 10 also is an antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 10 can be used for the research of invasive fungal infections (IFIs).
  • HY-117430
    Hymeglusin

    F-244; 1233A; L-659699

    Antibiotic Cancer Infection Metabolic Disease
    Hymeglusin, as a fungal β-lactone antibiotic, is a HMG-CoA synthase inhibitor (IC50 = 0.12 μM). Hymeglusin covalently modifies the active Cys 129 residue of the enzyme.
  • HY-151422
    Chitin synthase inhibitor 12

    Others Cancer Infection
    Chitin synthase inhibitor 12 is a chitin synthase (CHS) inhibitor. Chitin synthase inhibitor 12 shows excellent CHS inhibitory activity with an IC50 value of 0.16 mM. Chitin synthase inhibitor 12 also is a broad-spectrum antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 12 can be used for the research of invasive fungal infections (IFIs).
  • HY-B1858
    Isoprothiolane

    Fungal Infection
    Isoprothiolane is a systemic fungicide. Isoprothiolane is a rice blast controlling agent against the fungal disease of rice planty Pyvioutavia oryzae Cav.
  • HY-N10190
    Asperaculane B

    Parasite Endogenous Metabolite Infection
    Asperaculane B is a fungal metabolite against P. falciparum transmission with an IC50 of 7.89 µM. Asperaculane B also inhibits the development of asexual P. falciparum with IC50 of 3 µM, and it is nontoxic to human cells.
  • HY-N10227
    Geodin

    PAI-1 Antibiotic Infection Inflammation/Immunology
    Geodin, a fungal metabolite, shows antibacterial activity. Geodin also is an inhibitor of plasminogen activator inhibitor- 1 (PAI-1).
  • HY-114646
    TMC-205

    Endogenous Metabolite Cancer
    TMC-205 is a natural fungal metabolite with antiproliferative activity against cancer cell lines. TMC-205 is a transcriptional up-regulator of SV40 promoter.
  • HY-N7701A
    L-Triguluronic acid

    Fungal Infection
    L-Triguluronic acid is a linear polysaccharide copolymer composed of three L-guluronic acid (G) and can be used to from Alginate. Alginate is a generic name of unbranched polyanionic polysaccharides and can be used for the research of anti-fungal agents delivery carries.
  • HY-125170
    Galiellalactone

    STAT Cancer
    Galiellalactone is a is a small non-toxic and non-mutagenic fungal metabolite, a selective inhibitor of STAT3 signaling, with an IC50 of 250-500 nM. Galiellalactone can be used to research castration-resistant prostate cancer.
  • HY-N10192
    Aculene D

    Endogenous Metabolite Bacterial Infection
    Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations.
  • HY-136901
    Fusarochromanone

    FC-101

    Reactive Oxygen Species Cancer Cardiovascular Disease
    Fusarochromanone (FC-101) is a fungal metabolite with potent anti-angiogenic and anti-cancer activity. Fusarochromanone-activated JNK pathway is attributed to induction of reactive oxygen species (ROS).
  • HY-119552
    Acetylaszonalenin

    LL-S490β

    Endogenous Metabolite Neurokinin Receptor Neurological Disease
    Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent neurokinin-1 (NK1) receptor antagonist. Acetylaszonalenin shows inhibition of [ 3H]-SP binding to human astrocytoma cells with a Ki of 170 μM.
  • HY-119123
    Voxvoganan

    LTX-109

    Fungal Bacterial Infection
    Voxvoganan (LTX-109), a topical antimicrobial, is highly effective against S. aureus with a MIC range of 2 to 4 μg/mL. Voxvoganan can be used for the research of bacterial skin infections, fungal infections and nasal decolonisation of MRSA.
  • HY-120607
    Chevalone C

    Parasite Cancer Infection
    Chevalone C, a meroterpenoid fungal metabolite, shows antimalarial activity with IC50 value of 25.00 μg/mL. Chevalone C has anti-proliferative activity on colon HCT116, liver HepG2 and melanoma A375 cancer cell lines.
  • HY-126989
    19-O-Acetylchaetoglobosin A

    Arp2/3 Complex Cancer
    19-O-Acetylchaetoglobosin A, a cytochalasan alkaloid, is a fungal metabolite originally isolated from C. globosum that has actin polymerization inhibitory and cytotoxic activities. 19-O-Acetylchaetoglobosin A is cytotoxic to HeLa cervical cancer cells.
  • HY-N6748
    Roquefortine C

    P-glycoprotein Cytochrome P450 Bacterial Endogenous Metabolite Cancer Infection
    Roquefortine C, a fungal cyclopeptide isolated from Penicillium roquefortii, activates P-gp and also inhibits P450-3A and other haemoproteins. Roquefortine C has bacteriostatic activities against Gram-positive bacteria.
  • HY-151421
    Chitin synthase inhibitor 11

    Fungal Cancer Infection
    Chitin synthase inhibitor 11 is a chitin synthase (CHS) inhibitor. Chitin synthase inhibitor 11 shows excellent CHS inhibitory activity with an IC50 value of 0.10 mM. Chitin synthase inhibitor 11 has broad-spectrum antifungal activity in vitro. Chitin synthase inhibitor 11 can be used for the research of invasive fungal infections (IFIs).
  • HY-N8393
    Ascr#18

    Bacterial Fungal Infection
    Ascr#18, an ascaroside, is a hormone of nematodes. Ascr#18 is expressed during nematode development. Ascr#18 increases resistance in Arabidopsis, tomato, potato and barley to viral, bacterial, oomycete, fungal and nematode infections.
  • HY-118149A
    (±)9-HpODE

    Bacterial Fungal Parasite Infection
    (±)9-HpODE is a long chain lipid hydroperoxide, is a product of linoleic acid peroxidation. (±)9-HpODE can induce oxidation of intracellular glutathione (GSH). (±)9-HpODE also exhibits antimicrobial activity against various fungal and bacterial pathogens.
  • HY-N10322
    2-Hydroxyemodin

    Drug Metabolite Others
    2-Hydroxyemodin is an active metabolite of emodin in the hepatic microsomes. Emodin is an anthraquinone present in fungal metabolites and constituent of rhubarb. 2-Hydroxyemodin proves to be mutagenic to Salmonella typhimurium TA1537 in the absence of activation system.
  • HY-N8472
    Chrodrimanin B

    GABA Receptor Infection
    Chrodrimanin B, a metabolite of a fungal, is a potent, non-open-channel-blocking antagonist on B. mori GABAR RDL with an IC50 of 1.13 nM. Chrodrimanin B attenuates the peak current amplitude of the GABA response of RDL with an IC50 of 1.66 nM. Chrodrimanin B, a meroterpenoid, shows insecticidal activity.
  • HY-B1975
    Dithianon

    Fungal Reactive Oxygen Species Infection
    Dithianon is a broad-spectrum anthraquinone fungicide with good adherence to the surface of leaves and fruits. Dithianon is used to control several several fungal of some fruits and vegetables, as anthracnose (Colletotrichum sp., Elsinoe ampelina), mildew (Plasmopara viticola), phomopsis (Phomopsis viticola), among others.
  • HY-B1474
    Alexidine

    Fungal Infection Cancer
    Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis.
  • HY-147110
    APX2039

    Fungal Infection Inflammation/Immunology
    APX2039 is an orally active and potent inhibitor of the fungal Gwt1 enzyme. APX2039 has extremely potent anticryptococcal activity against C. neoformans and C. gattii. APX2039 blocks the localization of GPI (glycosylphosphatidyl inositol)-anchored cell wall mannoproteins. APX2039 can be used for Cryptococcal meningitis (CM) research.
  • HY-N6798
    Myriocin

    Thermozymocidin; ISP-I

    HCV Antibiotic Infection
    Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia, is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC50 of 3.5 µg/mL for inhibiting HCV infection.
  • HY-120733
    Calpinactam

    FKI-4905

    Bacterial Endogenous Metabolite Infection Inflammation/Immunology
    Calpinactam (FKI-4905), a fungal metabolite, is a new anti-mycobacterial agent.Calpinactam is active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibits the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 μg/ml, respectively.
  • HY-146079
    Antifungal agent 31

    Fungal Infection
    Antifungal agent 31 (compound 12) is a potent and orally active triazole antifungal agents with a pyrrolotriazinone scaffold. Antifungal agent 31 shows antifungal activity against Candida spp. and filamentous fungi. Antifungal agent 31 significantly reduced mortality rates and kidney fungal burden in two murine models of lethal systemic infections.
  • HY-17583
    Griseofulvin

    Fungal Apoptosis Antibiotic Endogenous Metabolite Infection Cancer
    Griseofulvin(Gris-PEG; Grifulvin) is a spirocyclic fungal natural product used in treatment of fungal dermatophytes; Antifungal drug.
  • HY-U00181
    Fludazonium chloride

    R23633

    Fungal Infection
    Fludazonium chloride (R23633) is an anti-fungal agent, which can be used in the treatment and prevention of superficial and systemic fungal infections.
  • HY-148054
    Antifungal agent 36

    Fungal Infection
    Antifungal agent 36 is a potent anti-fungal agent. Antifungal agent 36 shows anti-fungal activity for Basidiomycetes.
  • HY-126810
    NP213

    Fungal Infection
    NP213 is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 is effective and well-tolerated in resolving nail fungal infections.
  • HY-121721
    Inz-5

    Fungal Infection
    Inz-5 is a fungal-selective mitochondrial cytochrome bc1 inhibitor. Inz-5 impairs fungal virulence and prevents the evolution of drug resistance.
  • HY-129319
    Valinotricin

    Endogenous Metabolite Others
    Valinotricin is a fungal metabolite.
  • HY-17583S
    Griseofulvin-d3

    Fungal Apoptosis Antibiotic Endogenous Metabolite Infection Cancer
    Griseofulvin-d3 is the deuterium labeled Griseofulvin. Griseofulvin (Gris-PEG) is a spirocyclic fungal natural product used in treatment of fungal dermatophytes; Antifungal drug.
  • HY-126810A
    NP213 TFA

    Fungal Infection
    NP213 TFA is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 TFA targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 TFA is effective and well-tolerated in resolving nail fungal infections.
  • HY-123777
    VT-1598

    Fungal Infection Inflammation/Immunology
    VT-1598 is an orally active, novel and selective fungal CYP51 inhibitor. VT-1598 shows anti-fungal activity against Candida auris.
  • HY-B1839
    Fluazinam

    Fungal Infection
    Fluazinam is a broad spectrum pyridinamine fungal inhibitor.
  • HY-117713
    Cycloechinulin

    Others Others
    Cycloechinulin is a diketopiperazine fungal metabolite.
  • HY-N7697
    Chitotetraose tetrahydrochloride

    Others Others
    Chitotetraose tetrahydrochloride is an arbuscular mycorrhizal (AM) fungal short-chain chitin oligomer. Chitotetraose tetrahydrochloride activates the AM fungal-dependent conserved symbiosis signaling pathway (CSSP) in actinorhizal plant species.
  • HY-N6625
    Chlorothalonil

    Fungal Infection
    Chlorothalonil is a broad spectrum fungicide and is effective in protecting plants against fungal diseases caused mainly by Phytophthora infestans and Alternaria solani. Chlorothalonil is used for controlling of fungal foliar diseases of vegetables and crops.
  • HY-107417
    Hypothemycin

    VEGFR MEK FLT3 PDGFR ERK Cancer
    Hypothemycin, a fungal polyketide, is a multikinase inhibitor with Kis of 10/70 nM, 17/38 nM, 90 nM, 900 nM/1.5 μM, and 8.4/2.4 μM for VEGFR2/VEGFR1, MEK1/MEK2, FLT-3, PDGFRβ/PDGFRα, and ERK1/ERK2, respectively.
  • HY-N10282
    Isodihydroauroglaucin

    Fungal Bacterial Endogenous Metabolite Infection
    Isodihydroauroglaucin, a fungal metabolite, shows antibacterial activity.
  • HY-N10257
    Burnettramic acid A aglycone

    Endogenous Metabolite Others
    Burnettramic acid A aglycone is a fungal metabolite found in Aspergillus burnettii.
  • HY-139903
    Antifungal agent 18

    Fungal Infection
    Antifungal agent 18 is a novel antifungal agent for the treatment of fungal infection.
  • HY-103382
    Arcyriaflavin A

    Fungal Infection
    Arcyriaflavin A is a fungal metabolite obtained from the fungi, Nocardiopsis sp.
  • HY-B0370
    Tolnaftate

    NP-27

    Fungal Infection
    Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent. .
  • HY-B0101B
    Fluconazole mesylate

    UK 49858 mesylate

    Fungal Antibiotic Bacterial Infection Cancer
    Fluconazole (mesylate) is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.
  • HY-B0101A
    Fluconazole hydrate

    UK 49858 hydrate

    Fungal Antibiotic Bacterial Infection Cancer
    Fluconazole (hydrate) is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.
  • HY-B0105A
    (+)-Ketoconazole

    (+)-Ketoconazol; (+)-R 41400

    Fungal Cytochrome P450 Infection
    (+)-Ketoconazole ((+)-R 41400) is an imidazole anti-fungal agent, a CYP3A4 inhibitor.
  • HY-N6713
    (-)-Altenuene

    Others Others
    (-)-Altenuene is a heptaketide isolated from an endolichenic fungal strain Nigrospora sphaerica.
  • HY-119328
    Pestalotin

    Others Others
    Pestalotin, a fungal lactone, is a secondary metabolite of endophytic fungus Pestalotiopsis microspore.
  • HY-76200
    Voriconazole

    UK-109496

    Fungal Bacterial Infection Cancer
    Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes.
  • HY-144694
    HDAC/HSP90-IN-3

    HSP HDAC Fungal Infection
    HDAC/HSP90-IN-3 (compound J5) is a potent and selective fungal Hsp90 and HDAC dual inhibitor, with IC50 values of 0.83 and 0.91 μM, respectively. HDAC/HSP90-IN-3 shows antifungal activity against azole resistant C. albicans. HDAC/HSP90-IN-3 can suppress important virulence factors and down-regulate drug-resistant genes ERG11 and CDR1.
  • HY-A0277
    Cyproconazole

    Bacterial Others
    Cyproconazole is a triazole fungicide that is used agriculturally for protection of crops against a wide variety of fungal pathogens.
  • HY-N3617
    Coniferin

    Laricin

    Fungal Infection
    Coniferin (Laricin) is a glucoside of coniferyl alcohol. Coniferin inhibits fungal growth and melanization.
  • HY-129515
    Trichodecenin II

    Fungal Others
    Trichodecenin II is a fungal metabolite that can be found in conidia of the fungus, Trichoderma viride.
  • HY-B1702
    Nifuroxime

    Fungal Infection
    Nifuroxime is an anti-infective agent. Nifuroxime can be used in the research of fungal infections.
  • HY-114518
    Butenafine

    KP363

    Fungal Infection
    Butenafine (KP363) is a potent and broad spectrum benzylamine antifungal agent. Butenafine inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation, leading to a deficiency of the fungal cell membranes. Butenafine is effective against dermatophytes infections, such as  tinea pedis,  tinea cruris, tinea versicolor.
  • HY-76200B
    Voriconazole camphorsulfonate

    UK-109496 camphorsulfonate

    Fungal Bacterial Infection
    Voriconazole (UK-109496) camphorsulfonate is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole camphorsulfonate exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes.
  • HY-130214
    7-Hydroxypestalotin

    LL-P880β

    Endogenous Metabolite Others
    7-Hydroxypestalotin (LL-P880β) is a fungal metabolite.
  • HY-100527
    AN2718

    Fungal Infection
    AN2718 inhibits fungal growth by blocking protein synthesis using the oxaborole tRNA trapping (OBORT) mechanism.
  • HY-118330
    Apigeninidin chloride

    Gesneridin chloride; Apigenidin chloride

    Fungal Infection
    Apigeninidin (Gesneridin) chloride, a 3‐deoxyanthocyanidin, is a fungal growth inhibitor. Apigeninidin chloride is a bioactive red biocolorant.
  • HY-151410
    Chitin synthase inhibitor 5

    Fungal Infection
    Chitin synthase inhibitor 5 (compound 9a) is an inhibitor of chitin synthase with an IC50 value of 0.14 mM. Chitin synthase inhibitor 5 shows broad-spectrum antifungal activity in vitro and shows good inhibition to C. albicans, A. flavus, A. fumigatus and C. neoformans. Chitin synthase inhibitor 5 can be used for the research of fungal.
  • HY-101506
    2,4,6-Tribromophenyl caproate

    Fungal Infection
    2,4,6-Tribromophenyl caproate (2,4,6-tribromophenyl caproic acid ester) is an anti-fungal agent.
  • HY-139713
    Antifungal agent 14

    Fungal Infection
    Antifungal agent 14 exhibits broad-spectrum activity against the fungal strains with excellent minimum inhibitory concentration values.
  • HY-118100
    Cyclo(Tyr-Val)

    Cyclo(L-Tyr-L-Val)

    Drug Metabolite Others
    Cyclo(Tyr-Val) (Cyclo(L-Tyr-L-Val)) is a diketopiperazine secondary fungal metabolite originally isolated from N. gilva.
  • HY-B0105
    Ketoconazole

    Ketoconazol; R 41400

    Fungal Cytochrome P450 Ras Bacterial Infection Cancer
    Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
  • HY-N2519
    (E)-Coniferin

    (E)-Laricin

    Fungal Infection
    (E)-Coniferin is the isomer of Coniferin. Coniferin is a glucoside of coniferyl alcohol. Coniferin inhibits fungal growth and melanization.
  • HY-147876
    Antimicrobial agent-3

    Bacterial Fungal Infection
    Antimicrobial agent-3 (Compound U10) is an antimicrobial agent against bacterial, fungal and tubercular infections.
  • HY-U00007
    Stilbamidine

    Ba 2652; Stilbamidin

    Fungal Cancer Infection
    Stilbamidine is a diamidine compound derived from Stilbene and used chiefly in the form of its crystalline isethionate salt in treating various fungal infections.
  • HY-142908
    Maximiscin

    Others Cancer
    Maximiscin, a fungal metabolite, induces DNA damage and shows selective cytotoxic activity against a subtype of triple-negative breast cancer.
  • HY-N10261
    Methyl 3,4,5-trimethoxy-2-(2-(nicotinamido)benzamido)benzoate

    Endogenous Metabolite Others
    Methyl 3,4,5-trimethoxy-2-(2-(nicotinamido)benzamido)benzoate is a fungal metabolite.
  • HY-N4283
    Coniferyl alcohol

    Fungal Endogenous Metabolite Infection
    Coniferyl alcohol is an intermediate in biosynthesis of eugenol and of stilbenoids and coumarin. Coniferyl alcohol specifically inhibits fungal growth.
  • HY-N4181
    Kanzonol C

    Bacterial Fungal Infection
    Kanzonol C, a flavonoid isolated from the twigs of Dorstenia barteri (Moraceae), has potential to treat bacterial and fungal infections.
  • HY-P2318
    Bac2A TFA

    Fungal
    Bac2A TFA is an antimicrobial and immunomodulatory peptide. Bac2A TFA is a linear variant of bactenecin and is very effective against fungal pathogens.
  • HY-N10442
    Herqueilenone A

    Others Others
    Herqueilenone A is a benzoquinone-chromanon that can be found in the Hawaiian volcanic soil-associated fungal strain Penicillium herquei FT729[1].
  • HY-119726
    Fosmanogepix

    APX001; E1211

    Fungal Infection
    Fosmanogepix (APX001) is a first-in-class and orally available broad-spectrum antifungal agent, which targets the highly conserved Gwt1 fungal enzyme. Fosmanogepix (APX001) is an N-phosphonooxymethyl prodrug which is rapidly and completely metabolized by systemic alkaline phosphatases to the active moiety, APX001A. Fosmanogepix (APX001) can be used in development for the treatment of invasive fungal infections.
  • HY-N7453
    Fengycin

    Fungal Antibiotic Infection
    Fengycin is a cyclic lipopeptide used as an agricultural fungicide. Fengmycin has an anti-fungal infection effect by damaging the target's cell membrane.
  • HY-N6735
    Apicidin

    OSI 2040

    HDAC Parasite Cancer Infection
    Apicidin (OSI 2040) is a fungal metabolite, acts as a histone deacetylase (HDAC) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity.
  • HY-76200S
    Voriconazole-d3

    UK-109496-d3

    Fungal Infection
    Voriconazole-d3 (UK-109496-d3) is the deuterium labeled Voriconazole. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes.
  • HY-B0914A
    10-Undecenoic acid zinc salt

    Zinc undecylenate

    Fungal Antibiotic Endogenous Metabolite Infection
    10-Undecenoic acid zinc salt is a natural or synthetic fungistatic fatty acid, is used topically in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions.
  • HY-N6051
    (-​)​-Maackiain

    Fungal Infection
    (-)-Maackiain is a pterocarpan phytoalexin produced from Sophora flavescens. (-)-Maackiain is toxic to several genera of fungal pathogens of legume and non legume hosts.
  • HY-111911
    Xanthocillin X permethyl ether

    Amyloid-β Neurological Disease
    Xanthocillin X permethyl ether is a natural compound isolated from fungal extracts, with Aβ-42 lowering activity.
  • HY-125319
    Amidepsine A

    Acyltransferase Metabolic Disease
    Amidepsine A is a fungal metabolite isolated from the culture broth of Humicola sp. FO-2942 that inhibits Diacylglycerol acyltransferases (DGAT) activity.
  • HY-139900
    Benzyl 2-hydroxy-6-methoxybenzoate

    Fungal Infection
    Benzyl 2-hydroxy-6-methoxybenzoate shows the strongest antifungal effect, with IC50 of 25–26 μg/mL for both fungal strains.
  • HY-N1579
    Pyrogallol

    Endogenous Metabolite Fungal Apoptosis Infection
    Pyrogallol is a polyphenol compound, which has anti-fungal and anti-psoriatic properties. Pyrogallol is a reductant that is able to generate free radicals, in particular superoxide anions.
  • HY-N10262
    Piliformic acid

    Endogenous Metabolite Others
    Piliformic acid is a fungal metabolite found in the endophytic fungus Xylariasp sp.(No. 2508) from mangrove trees from the coast of the South China Sea.
  • HY-B0221
    Amphotericin B

    Fungal Antibiotic Bacterial Parasite Infection Cancer
    Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
  • HY-111357
    Antifungal agent 2

    Fungal Infection
    Antifungal agent 2 is a broad-spectrum fungal inhibitor which inhibits growth of pertinent species of Candida, Cryptococcus, and Aspergillus at a concentration as low as 0.5 μg/mL.
  • HY-129295
    Amidepsine D

    Acyltransferase Metabolic Disease
    Amidepsine D is a fungal metabolite isolated from the culture broth of Humicola sp. FO-2942 that inhibits Diacylglycerol acyltransferases (DGAT) activity.
  • HY-119630
    Propineb

    Zinc propylenebis(dithiocarbamate)

    Bacterial Infection
    Propineb (Zinc propylenebis) is a compound widely used in fruit and vegetables cultures, due to its large spectrum of activity against fungal plant diseases.
  • HY-N8400
    Roridin L2

    Endogenous Metabolite Others
    Roridin L2, a fungal metabolite, is a biosynthetic precursor of Satratoxin G. Roridin L2 possesses little in vitro or in vivo toxic activity.
  • HY-N8390
    3-Epidehydropachymic acid

    Others Cancer
    3-Epidehydropachymic acid, a lanostane triterpenoid, shows totoxicity effect against human acute monocytic leukemia cell line THP-1 (IC50=52.51 μM).
  • HY-N5003
    Columbianetin

    Fungal Infection Inflammation/Immunology
    Columbianetin is a phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage. Columbianetin exhibits excellent anti-fungal and anti-inflammatory activity.
  • HY-B2004
    Thifluzamide

    Fungal Infection
    Thifluzamide, a broad-spectrum succinate dehydrogenase inhibitor (SDHI) fungicide, has been widely used in the controlling of a variety of fungal diseases in rice fields.
  • HY-145814
    HSP90-IN-9

    HSP Fungal Infection
    HSP90-IN-9 is a potent and selective HSP90 inhibitor. HSP90-IN-9 displays a fungicidal effect in a dose-dependent manner. HSP90-IN-9 inhibits fungal biofilm formation and fungal morphological changes after being combined with FLC. HSP90-IN-9 recovers FLC resistance by down-regulating the expression of related genes (ERG11, CDR1 and CDR2).
  • HY-N6781
    Ophiobolin A

    Phosphodiesterase (PDE) Cancer Infection
    Ophiobolin A, a fungal metabolite and a phytotoxin, is a potent and irreversibly inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase, with an IC50 value of 9 μM. Ophiobolin A antimicrobial and anticancer activity.
  • HY-N6647
    Luteolin-7-rutinoside

    Fungal Infection Inflammation/Immunology
    Luteolin-7-rutinoside has both anti-arthritic and antifungal activities, can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection.
  • HY-B0105S
    Ketoconazole-d8

    Fungal Cytochrome P450 Ras Infection Cancer
    Ketoconazole-d8 is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
  • HY-18233
    E1210

    APX001A

    Fungal Infection
    E1210 is a first-in-class, broad-spectrum and orally active antifungal. E1210 has a mechanism of action-inhibition of fungal glycosylphosphatidylinositol (GPI) biosynthesis.
  • HY-121532
    (-)-Rasfonin

    Ras Apoptosis Autophagy Cancer
    (-)-Rasfonin is a fungal secondary metabolite and inhibits small G proteins Ras. (-)-Rasfonin induces apoptosis, necrosis and autophagy in ACHN cells (a renal carcinoma cell line).
  • HY-W002116
    Methyl syringate

    TRP Channel Inflammation/Immunology
    Methyl syringate, a chemical marker of asphodel monofloral honey, is an efficient phenolic mediator for bacterial and fungal laccases. Methyl syringate is a TRPA1 agonist.
  • HY-B0238
    Amorolfine hydrochloride

    Ro 14-4767/002

    Fungal Antibiotic Infection
    Amorolfine (Ro 14-4767/002) hydrochloride is a potent anti-fungal agent. Amorolfine hydrochloride inhibits ergosterol biosynthesis. Amorolfine hydrochloride has the potential for the research of Neoscytalidium dimidiatum onychomycosis.
  • HY-B2053
    Tolclofos-methyl

    Bacterial Infection
    Tolclofos-methyl is a broad-spectrum aromatic hydrocarbon fungicide that is used as a see treatment for protection against soil-borne and seed borne fungal pathogens that caused seed decay and seedling blights.
  • HY-B1747
    Pyrithione

    Bacterial Fungal Infection
    Pyrithione, a Transition metal complexe, is a zinc ionophore that causes increased zinc levels within mammalian cells. Pyrithione has potent bactericidal and anti-fungal activity.
  • HY-N6770
    Curvularin

    (S)-Curvularin

    NO Synthase Inflammation/Immunology Infection
    Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM.
  • HY-B0370S
    Tolnaftate (D7)

    Fungal Infection
    Tolnaftate D7 (NP-27 D7) is the deuterium labeled Tolnaftate. Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent.
  • HY-N0363
    (+)-Columbianetin

    (S)-Columbianetin

    Fungal Infection Inflammation/Immunology
    (+)-Columbianetin is an isomer of Columbianetin. Columbianetin is a phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage. Columbianetin exhibits excellent anti-fungal and anti-inflammatory activity.
  • HY-16589
    Oligomycin A

    MCH 32

    ATP Synthase Fungal Antibiotic Cancer Infection
    Oligomycin A (MCH 32), created by Streptomyces, acts as a mitochondrial F0F1-ATPase inhibitor, with a Ki of 1 μM; Oligomycin A shows anti-fungal activity.
  • HY-P2228
    Chlamydocin

    HDAC Apoptosis Cancer
    Chlamydocin, a fungal metabolite, is a highly potent HDAC inhibitor, with an IC50 of 1.3 nM. Chlamydocin exhibits potent antiproliferative and anticancer activities. Chlamydocin induces apoptosis by activating caspase-3.
  • HY-P3042
    Chymostatin

    Cathepsin Inflammation/Immunology
    Chymostatin is a potent cathepsin G inhibitor. Chymostatin inhibits fungal growth when combined with other pepsin inhibitors. Chymostatin can be used for acute lung injury and pancreatitis research.
  • HY-N0334
    (+)-Magnoflorine

    Magnoflorine; α-Magnoflorine; Thalictrine

    Fungal Infection Metabolic Disease
    (+)-Magnoflorine (Magnoflorine), an aporphine alkaloid found in Acoruscalamus, reduces the formation of C. albicans biofilm. (+)-Magnoflorine has anti-fungal, anti-antidiabetic and anti-oxidative activity.
  • HY-N6774
    Cytochalasin C

    Others Infection
    Cytochalasin C is a cell-permeable fungal toxin and induces the formation of nuclear rodlets. Cytochalasin C is 10 times less toxic in mice than is cytochalasin D.
  • HY-W019803
    Diclobutrazol

    Fungal Infection Others
    Diclobutrazol, a systemic fungicide, is highly active against rusts, powdery mildews, and other fungal phytopathogens. Diclobutrazol can be used as a pesticide to control of various crop diseases.
  • HY-N6656
    6-Hydroxycoumarin

    Fungal Bacterial Cancer Inflammation/Immunology
    6-Hydroxycoumarin is a coumarin which has anti-inflammatory, anti-pyretic, anti-oxidant, vasodilator, anti-amoebic, anti-bacterial, anti-fungal, bacteriostatic and antitumor activity.
  • HY-129060
    Flutrimazole

    Fungal Infection
    Flutrimazole is an imidazole antifungal with dual anti-inflammatory and antifungal activity. Flutrimazole shows scarce transdermal penetration. Flutrimazole has the advantageous in the research of topical fungal infections with an inflammatory component.
  • HY-N2014
    Verbenalin

    SARS-CoV Infection Inflammation/Immunology
    Verbenalin is Verbena glycoside, with anti-inflammatory, anti-fungal anti-virus activities. Verbenalin can be used for the research of prostatitis. Verbenalin can reduce cerebral ischemia-reperfusion injury.
  • HY-N0535
    (+)-Magnoflorine chloride

    Magnoflorine chloride; α-Magnoflorine chloride; Thalictrine chloride

    Fungal Infection Metabolic Disease
    Magnoflorine chloride (Magnoflorine chloride), an aporphine alkaloid found in Magnolia or Aristolochia, reduces the formation of C. albicans biofilm. Magnoflorine chloride has anti-fungal, anti-antidiabetic and anti-oxidative activity.
  • HY-N0363A
    (+)-Columbianetin acetate

    (S)-Columbianetin acetate

    Fungal Infection Inflammation/Immunology
    (S)-Columbianetin acetate is an isomer of Columbianetin. Columbianetin is a phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage. Columbianetin exhibits excellent anti-fungal and anti-inflammatory activity.
  • HY-N6626
    Pyraclostrobin

    Fungal Bacterial Infection Metabolic Disease
    Pyraclostrobin is a strobilurin fungicide that inhibits mitochondrial complex III of fungal and mammalian cells. Pyraclostrobin induces triglyceride accumulation and triglyceride accumulation in 3T3-L1 cells.
  • HY-125706
    1233B

    Fungal Antibiotic Infection
    1233B is a secondary metabolite from filamentous fungus, Fusarium sp. RK97-94.
  • HY-B1858S
    Isoprothiolane-d4

    Fungal Infection
    Isoprothiolane-d4 is the deuterium labeled Isoprothiolane. Isoprothiolane is a systemic fungicide. Isoprothiolane is a rice blast controlling agent against the fungal disease of rice planty Pyvioutavia oryzae Cav.
  • HY-108547
    Alexidine dihydrochloride

    Fungal Apoptosis Infection
    Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens.
  • HY-B0105S1
    Ketoconazole-d4

    Ketoconazol-d4; R 41400-d4

    Fungal Cytochrome P450 Ras Infection Cancer
    Ketoconazole-d4 (Ketoconazol-d4) is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
  • HY-17643
    Oteseconazole

    VT-1161

    Fungal Cytochrome P450 Infection
    Oteseconazole (VT-1161) is an orally active anti-fungal agent, potently binds to and inhibits Candida albicans CYP51 (Kd, <39 nM), shows no obvious effect on human CYP51.
  • HY-B1144A
    Chlormidazole hydrochloride

    Clomidazole hydrochloride

    Fungal Infection
    Chlormidazole hydrochloride is an antifungal agent and has inhibitory activity against many fungi and some gram-positive cocci. Chlormidazole hydrochloride can be applied in fungal and bacterial infections of nails and skin, including interdigital and periungual mycoses.
  • HY-111321
    Fuscin

    CCR HIV Bacterial Mitochondrial Metabolism Endogenous Metabolite Infection Metabolic Disease
    Fuscin, a fungal metabolite, CCR5 receptor antagonist with anti-HIV effects. Fuscin is a respiration and oxidative phosphorylation inhibitor, and also a mitochondrial SH-dependent transport-linked functions inhibitor.
  • HY-147814
    KFU-127

    Bacterial Fungal Infection
    KFU-127 (Compound 6b) is a broad spectrum topical antimicrobial capable of one-shot targeting of bacterial and fungal-bacterial biofilms. KFU-127 is considerably toxic for eukaryotic cells.
  • HY-122493
    Illudin M

    DNA Alkylator/Crosslinker Apoptosis Cancer
    Illudin M is a cytotoxic fungal sesquiterpene that can be isolated from the culture medium of Omphalotus olearius mushrooms. Illudin M can alkylate DNA. Illudin M has anti-tumor activities.
  • HY-N0334A
    (+)-Magnoflorine iodide

    Magnoflorine iodide; α-Magnoflorine iodide; Thalictrine iodide

    Fungal Infection Metabolic Disease
    (+)-Magnoflorine iodide (Magnoflorine iodide), an aporphine alkaloid found in Acoruscalamus, reduces the formation of C. albicans biofilm. (+)-Magnoflorine iodide has anti-fungal, anti-antidiabetic and anti-oxidative activity.
  • HY-109040
    Quilseconazole

    VT-1129

    Fungal Cytochrome P450 Infection
    Quilseconazole (VT-1129) is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor, binds tightly to cryptococcal CYP51, but weakly inhibits humans CYP450 enzymes.
  • HY-151439
    Antifungal agent 41

    Fungal Infection
    Antifungal agent 41 (compound B01) is an antifungal agent. Antifungal agent 41 shows inhibitory effect on Candida albicans in virto and vivo. Antifungal agent 41 can be used for the research of invasive fungal infections.
  • HY-N10265
    Stephacidin B

    Endogenous Metabolite Cancer
    Stephacidin B is a fungal metabolite. Stephacidin B shows in vitro cytotoxicity against a panel of human tumor cell lines. Stephacidin B shows the strongest cytotoxicity against testosterone-dependent prostate LNCaP cancer cells.
  • HY-14273
    Isavuconazole

    BAL-4815; RO-0094815

    Fungal Cytochrome P450 Antibiotic Infection
    Isavuconazole (BAL-4815) is a triazole prodrug with antifungal activity against yeasts, molds, and dimorphic fungi. Isavuconazole inhibits ergosterol biosynthesis and results in the disruption of fungal membrane structure and function. Isavuconazole is a moderate inhibitor of CYP3A4.
  • HY-N1214
    Squalene

    Super Squalene; trans-Squalene; AddaVax

    Endogenous Metabolite Reactive Oxygen Species Fungal Infection Cardiovascular Disease
    Squalene is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, cardioprotective, antioxidant, and antitoxicant activity. Squalene also has anti-fungal activity and can be used for the research of Trichophyton mentagrophytes treatment.
  • HY-B0348
    Liranaftate

    Piritetrate; M-732

    Fungal Infection
    Liranaftate (Piritetrate) is a squalene epoxidase inhibitor with anti-fungicidal activities. Liranaftate can be used for the research of dermatophytes. Liranaftate also suppresses fungal element-promoted production of IL-8 and experimental inflammation.
  • HY-N6772
    Cytochalasin E

    Autophagy Cancer
    Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation.
  • HY-125776
    Kresoxim-methyl

    BAS 490 F

    Fungal Mitochondrial Metabolism Infection
    Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the complex III (cytochrome bc1 complex). Kresoxim-methyl binds to complex III from yeast with an apparent Kd of 0.07 μM proving a high affinity for this enzyme.
  • HY-145437
    N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide

    Fungal Infection
    N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide is a Ole1p desaturase inhibitor and antifungal agent.
  • HY-121184
    Epicoccamide

    Endogenous Metabolite Others
    Epicoccamide, a tetramic acid derivative, is secondary metabolite from Epicoccum purpurascens.
  • HY-75564
    Cyclo(Ala-Gly)

    Endogenous Metabolite Cancer
    Cyclo(Ala-Gly), a metabolite of a mangrove endophytic fungus, Penicillium thomi, exhibits cytotoxicity against A549, HepG2 and HT29 cells. The IC50 values range from 9.5 to 18.1 μM.
  • HY-N7701C
    L-Pentaguluronic acid

    Others Infection
    L-Pentaguluronic acid is a linear polysaccharide copolymer composed of four L-guluronic acid (G).
  • HY-N7701
    L-Diguluronic acid

    Fungal Infection
    L-Diguluronic acid is a linear polysaccharide copolymer composed of two L-guluronic acid (G) and can be used to from Alginate. Alginate is a generic name of unbranched polyanionic polysaccharides and can be used for the research of antifungal agents delivery carries.
  • HY-N7701D
    L-Hexaguluronic acid

    Others Infection
    L-Hexaguluronic acid is a linear polysaccharide copolymer composed of six L-guluronic acid (G).
  • HY-N7701B
    L-Tetraguluronic acid

    Others Infection
    L-Tetraguluronic acid is a linear polysaccharide copolymer composed of four L-guluronic acid (G).
  • HY-N10205
    Rostratin C

    Endogenous Metabolite Cancer
    Rostratin C, a cytotoxic disulfide, shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC50 value of 0.76μg /mL.
  • HY-12686
    5Z-7-Oxozeaenol

    FR148083; L783279; LL-Z 1640-2

    MAP3K VEGFR Antibiotic Infection Inflammation/Immunology
    5Z-7-Oxozeaenol is a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC50s of 8 nM and 52 nM, respectively.
  • HY-W145584S
    D-Iditol-13C

    Endogenous Metabolite Cancer Metabolic Disease
    D-Iditol-13C is the 13C labeled D-Iditol. D-Iditol is a fungal metabolite, a sugar alcohol that accumulates in galactokinase deficiency. D-Iditol may have potential antitumour activity.
  • HY-129055
    Isoeleutherin

    Fungal Inflammation/Immunology
    Isoeleutherin is a naphthopyran derivative isolated from E. americana Merr. Et Heyne with anti-fungal, anti-viral, and anti-tumor activities. Isoeleutherin plays an important role in selective modulation of T helper cell-mediated immune responses.
  • HY-135549
    Fluxapyroxad

    Fungal Antibiotic Infection
    Fluxapyroxad is a synthetic broad-spectrum fungicide for the control of fungal diseases. It works by inhibiting succinate dehydrogenase in complex II of the mitochondrial respiratory chain, resulting in inhibition of spore germination, germ tubes and mycelia growth within the fungus target species.
  • HY-N6679A
    10,11-Dehydrocurvularin

    HSP TGF-beta/Smad Cancer Infection
    10,11-Dehydrocurvularin is a prevalent fungal phytotoxin and an antibiotic. 10,11-Dehydrocurvularin is a strong activator of the heat shock response. 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity.
  • HY-N6697
    Aflatoxin G1

    Bacterial Antibiotic Parasite Cancer Infection
    Aflatoxin G1 is one type of aflatoxins occuring in nature. It is produced by molds, such as Aspergillus flavus and Aspergillus parasiticus. Aflatoxins are hepatogenic, teratogenic, imunosuppressive, and carcinogenic fungal metabolites found in feeds, nuts, wine-grapes, spices, and other grain crops.
  • HY-N0889
    Ginkgetin

    Wnt Apoptosis Autophagy Inflammation/Immunology Cancer
    Ginkgetin, a biflavone, is isolated from Ginkgo biloba leaves. Ginkgetin exhibit anti-tumor, anti-inflammatory, neuroprotective, anti-fungal activities. Ginkgetin is also a potent inhibitor of Wnt signaling, with an IC50 of 5.92 μΜ.
  • HY-N7330
    Integracin B

    HIV Integrase HIV Infection
    Integracin B is a potent dimeric alkyl aromatic inhibitor of HIV-1 integrase discovered from the screening of fungal extracts using an in vitro assay. Integracin B inhibits both coupled and strand transfer activity of HIV-1 integrase.
  • HY-N1131
    Triacetonamine

    2,2,6,6-Tetramethyl-4-piperidone

    Others Others
    Triacetonamine is used as an intermediate for the synthesis of pharmaceutical products, pesticides and photostabilizers for polymers. Triacetonamine is an artifact of plant and fungal extracts using acetone and ammonium hydroxide or natural occurrence of ammonium salts in various steps of the isolation procedures. TAA is the main component of the pyrolysis oil.
  • HY-146190
    Callophycin A

    Bacterial Antibiotic Infection Inflammation/Immunology
    Callophycin A, a red seaweed derived metabolite, possessing potent activity against Candida albicans with MIC of 62.5~250 mg/L. Callophycin A significantly reduces fungal burden of vaginal candidiasis induced mice, also decreases inflammatory response and immune molecules.
  • HY-N0126
    Xanthone

    Bacterial Influenza Virus Fungal Apoptosis Cancer Infection Inflammation/Immunology
    Xanthone is isolated from Mangosteen and is known to control cell division and growth, apoptosis, inflammation, and metastasis in different stages of carcinogenesis. Xanthone has anti-oxidant, anti-tumor, anti-allergic, anti-inflammatory, anti-bacterial, anti-fungal, and anti-viral activities.
  • HY-Y1250S4
    Fmoc-Gly-OH-1-13C

    Fungal Infection Cancer
    Fmoc-Gly-OH-1-13C is a 13C-labeled Carbendazim. Carbendazim is a potent and orally active broad-spectrum benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria, Fusarium and Sclerotina[1][3]. Carbendazim is a
  • HY-129578
    Asperphenamate

    Autophagy Cathepsin Cancer Infection Inflammation/Immunology
    Asperphenamate, a fungal metabolite of Aspergillus flatiipes with anti-cancer effect, exhibits IC50 values of 92.3 μM, 96.5 μM and 97.9 μM in T47D, MDA-MB-231 and HL-60 cells, respectively.
  • HY-B0133
    Natamycin

    Pimaricin

    Fungal Endogenous Metabolite Antibiotic Bacterial Infection
    Natamycin (Pimaricin) is a macrolide antibiotic agent produced by several Streptomyces strains. Natamycin inhibits the growth of fungi via inhibition of amino acid and glucose transport across the plasma membrane. Natamycin is a food preservative, an antifungal agent in agriculture, and is widely used for fungal keratitis research.
  • HY-N6773
    Cytochalasin A

    HIV Protease Fungal Infection
    Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives.
  • HY-136063
    Mefentrifluconazole

    Fungal Cytochrome P450 Infection
    Mefentrifluconazole is a novel azole derivative and used as an agrochemical broad-spectrum antifungal agent. Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM).
  • HY-N6027
    Cyclosporin C

    Fungal Bacterial Infection
    Cyclosporin C is a fungal metabolite that has been found in T. inflatum and has diverse biological activities, including antifungal, antiviral, and immunosuppressant properties. Cyclosporin C is active against isolates of B. cinerea, A. niger, and Alternaria, Mucor, and Penicillium species (MICs=0.1-5 μg/ml).
  • HY-N0393
    Glabridin

    PPAR Reactive Oxygen Species Bacterial Cancer Infection Inflammation/Immunology
    Glabridin is a natural isoflavan from Glycyrrhiza uralensis, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities.
  • HY-100373
    Isavuconazonium sulfate

    BAL8557-002

    Fungal Infection
    Isavuconazonium sulfate (BAL8557-002), the prodrug of the active triazole Isavuconazole, is an orally active antifungal agent. Isavuconazonium sulfate is used for invasive aspergillosis and mucormycosis.
  • HY-100618
    Hispidin

    PKC Endogenous Metabolite Metabolic Disease Cardiovascular Disease
    Hispidin, a PKC inhibitor and a phenolic compound from Phellinus linteus, has been shown to possess strong anti-oxidant, anti-cancer, anti-diabetic, and anti-dementia properties.
  • HY-123037
    Triadimefon

    Fungal Infection
    Triadimefon is a triazole fungicide used to control powdery mildew, rusts, and other fungal pests on grains, fruit and vegetable crops, turf, shrubs, and trees. Triadimefon inhibits lanosterol 14α-demethylase, interfering with oxidative demethylation reactions in the ergosterol biosynthesis pathway of fungi, and also blocks gibberellin biosynthesis.
  • HY-B0843S1
    Metalaxyl-d6

    Fungal Infection
    Metalaxyl-d6 is the deuterium labeled Metalaxyl. Metalaxyl is a fungicide that inhibits protein synthesis in fungi. Metalaxyl inhibits the growth of potato blight (P. infestans) fungal isolates from Serbian potato fields (EC50s=0.3-3.9 μg/mL).
  • HY-13582
    Carbendazim

    Fungal Parasite Infection Cancer
    Carbendazim is a potent and orally active broad-spectrum benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as SeproriaFusarium and Sclerotina. Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma.
  • HY-N8537
    Enfumafungin

    Fungal Infection
    Enfumafungin, a triterpene glycoside, is isolated from extracts derived from fungus Hormonema carpetanum. Enfumafungin is an antifungal compound that is acting on the fungal cell wall, as the (1,3)-beta-D-glucan synthase inhibitor. Enfumafungin is specific for yeasts and fungi (excluding Cryptococcus) and does not inhibit the growth of Bacillus subtilis.
  • HY-P2365
    Histatin-8

    Fungal Infection
    Histatin-8 is a part of the Histatin-3 central sequence and is known as hemagglutination-inhibiting peptide. Histatin-8 is a potent anti-fungal peptide. Histatin-8 shows antimicrobial activity against yeast strains. Histatin-8 can be used for oral thrush research.
  • HY-B2033
    Pyrimethanil

    Fungal Infection
    Pyrimethanil is an anilinopyrimidine and broad-spectrum contact fungicide for the control of Botrytis spp. on a wide variety of crops. Pyrimethanil inhibits the biosynthesis of methionine and other amino acids in Botrytis cinerea. Pyrimethanil can be used for the research of fungal diseases prevention on fruit, vegetable and ornamental plants with mold infection.
  • HY-130703
    5-Dehydroepisterol

    Fungal Infection
    5-Dehydroepisterol is an episterol derivative and an intermediate in steroid biosynthesis. 5-Dehydroepisterol can be formed by C-5 sterol desaturase and converted into 24-methylenecholesterol by 7-dehydrocholesterol reductase. 5-Dehydroepisterol has anti-fungal activities.
  • HY-N0662
    Amentoflavone

    Didemethyl-ginkgetin

    Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor Cancer Infection Inflammation/Immunology Neurological Disease
    Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase.
  • HY-14282
    Lanoconazole

    Fungal Infection Inflammation/Immunology
    Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis.
  • HY-N10219
    Dihydroaltenuene B

    Tyrosinase Fungal Infection
    Dihydroaltenuene B is a potent mushroom tyrosinase inhibitor with an IC50 of 38.33 µM. Dihydroaltenuene B shows the hydrogen bonding interactions between the 3-OH and 4’-OH and the His244, Met280 and Gly281 residues of tyrosinase.
  • HY-N10196
    Cerebroside D

    Endogenous Metabolite Inflammation/Immunology
    Cerebroside D, a glycoceramide compound, improves experimental colitis in mice with multiple targets against activated T lymphocytes.
  • HY-17395B
    Terbinafine lactate

    TDT 067 lactate

    Antibiotic Fungal Bacterial Infection
    Terbinafine lactate (TDT 067 lactate) is an orally active and potent antifungal agent. Terbinafine lactate is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine lactate also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria.
  • HY-17395
    Terbinafine hydrochloride

    TDT 067 hydrochloride

    Fungal Bacterial Antibiotic Infection
    Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. Terbinafine hydrochloride is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine hydrochloride also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria.
  • HY-17395A
    Terbinafine

    TDT 067

    Fungal Bacterial Antibiotic Infection
    Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria.
  • HY-13557
    Ascomycin

    Immunomycin; FR-900520; FK520

    FKBP Parasite Fungal Antibiotic Infection Inflammation/Immunology Neurological Disease
    Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research.
  • HY-B0843S
    Metalaxyl-13C6

    Fungal Infection
    Metalaxyl-13C6 is the 13C-labeled Metalaxyl. Metalaxyl is a fungicide that inhibits protein synthesis in fungi. Metalaxyl inhibits the growth of potato blight (P. infestans) fungal isolates from Serbian potato fields (EC50s=0.3-3.9 μg/mL).
  • HY-N1131B
    Triacetonamine monohydrate

    2,2,6,6-Tetramethyl-4-piperidone monohydrate

    Others Others
    Triacetonamine (2,2,6,6-Tetramethyl-4-piperidone) monohydrate is used as an intermediate for the synthesis of pharmaceutical products, pesticides and photostabilizers for polymers. Triacetonamine monohydrate is an artifact of plant and fungal extracts using acetone and ammonium hydroxide or natural occurrence of ammonium salts in various steps of the isolation procedures. Triacetonamine monohydrate is the main component of the pyrolysis oil.
  • HY-15660
    Efinaconazole

    KP-103

    Fungal Infection
    Efinaconazole (KP-103) is a triazole antifungal agent and againsts T. mentagrophytes SM-110 and C. albicans ATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively. Efinaconazole has a potent in vitro activity against fungal pathogens including dermatophytes, Candida and Malassezia species.
  • HY-N7030
    5,7,3',4'-Tetramethoxyflavone

    Fungal Parasite Infection
    5,7,3',4'-Tetramethoxyflavone, one of the major polymethoxyflavones (PMFs) isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling.
  • HY-124701
    Filastatin

    Fungal Infection
    Filastatin is a long-lasting inhibitor of Candida albicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC50 of ~3 μM in the GFP-based adhesion assay. Filastatin inhibits fungal adhesion to polystyrene and human cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter. Filastatin has potent antifungal effect.
  • HY-N2499
    Dehydrotumulosic acid

    Others Metabolic Disease
    Dehydrotumulosic acid is one of the effective constituents of Poria cocos. Poria cocos, a popular Chinese medicinal herb of fungal origin, has been included in many combinations with other CM herbs for its traditionally claimed activities of inducing diuresis, excreting dampness, invigorating the spleen and tranquilizing the mind and its modern pharmacological use of modulating the immune system of the body.
  • HY-N6801
    Nivalenol

    Caspase Bacterial Apoptosis Antibiotic Infection Inflammation/Immunology
    Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product. Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect.
  • HY-14282A
    (Z)-Lanoconazole

    Fungal Infection Inflammation/Immunology
    (Z)-Lanoconazole is the Z configuration of Lanoconazole. Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis.
  • HY-13582S
    Carbendazim-d4

    Fungal Infection Cancer
    Carbendazim-d4 is the deuterium labeled Carbendazim. Carbendazim is a potent and orally active broad-spectrum benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as SeproriaFusarium and Sclerotina. Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma.
  • HY-143290
    Antibacterial agent 118

    Bacterial Infection
    Antibacterial agent 118 (compound 20) is an antimycobacterial agent. Antibacterial agent 118 shows antibacterial activity against Mtb H37Ra, M. aurum, M. smegmatis, Mtb H37Rv and M. avium with MIC values of 40.7, 10.2, 163.0, 62.5 and 62.5 μM, respectively. Antibacterial agent 118 can be used for the research of tuberculosis.
  • HY-129555
    Surfactin

    Bacterial HSV Antibiotic Infection
    Surfactin is a potent cyclic lipopeptide biosurfactants consists of four isomers (Surfactin A, B, C and D), which mediates flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes. Surfactin can act as an antimicrobial adjuvant with anti-bacterial, anti-fungal, antimycoplasma and hemolytic effects. Surfactin also has antiviral activity against a variety of enveloped viruses.
  • HY-17395S
    Terbinafine-d3 hydrochloride

    TDT 067-d3 hydrochloride

    Fungal Bacterial Antibiotic Infection
    Terbinafine-d3 (TDT 067-d3) hydrochloride is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM. Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria.
  • HY-14282S
    Lanoconazole-d3

    Fungal Infection Inflammation/Immunology
    Lanoconazole-d3 is the deuterium labeled Lanoconazole. Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis.
  • HY-17395AS
    Terbinafine-d7

    TDT 067-d7

    Fungal Bacterial Antibiotic Infection
    Terbinafine-d7 (TDT 067-d7) is the deuterium labeled Terbinafine. Terbinafine (TDT 067) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM. Terbinafine also antibacterial activity against certain Gram-positive and Gram-negative bacteria.
  • HY-144632
    Antifungal agent 22

    Fungal Infection
    Antifungal agent 22 (compound D16) is a potential and orally active antifungal agent for CM (cryptococcal meningitis), with an IC50 of 0.5 μg/mL. Antifungal agent 22 can penetrate the blood-brain barrier and kill the C. neoformans H99 cells by destroying the integrity of fungal cell membranes. Antifungal agent 22 shows selective anti-Cryptococcus activity with good metabolic stability and low cytotoxicity.
  • HY-N144114
    P-gp inhibitor 2

    P-glycoprotein Cancer
    P-gp inhibitor 2 is a potent P-gp inhibitor. P-gp inhibitor 2 shows reverse Doxorubicin resistance (IC50=0.22 µM) in P-gp overexpressing human colorectal carcinoma cells (SW600 Ad300).
  • HY-143232
    Antibacterial agent 73

    Fungal Bacterial Cancer Infection
    Antibacterial agent 73 (compound 7a) is a potent antimicrobial agent. Antibacterial agent 73 exhibits very good antitubercular activity (MIC=0.65 µg/mL) against Mtb H37Rv. Antibacterial agent 73 shows good activity against fungal and bacterial. Antibacterial agent 73 also shows cytotoxicity in MCF-7 breast cancer cell lines, with IC50 of 8.20 μM.
  • HY-126396
    Sordarin sodium

    CaMK Fungal Antibiotic Infection Inflammation/Immunology
    Sordarin is a potent diphthamide-dependent eEF2 inhibitor with antifungal properties. Sordarin targets eEF2 so as to inhibit protein translation by blocking eEF2-mediated translocation of tRNAs. Sordarin inhibits translation specifically in certain fungi (e.g. C. albicansC. glabrata, and C. neoformans) while unable to do so in some other fungal species (e.g. Candida parapsilosis and Candida lusitaniae).
  • HY-15660S
    Efinaconazole-d4

    KP-103-d4

    Fungal Infection
    Efinaconazole-d4 (KP-103-d4) is the deuterium labeled Efinaconazole. Efinaconazole (KP-103) is a triazole antifungal agent and againsts T. mentagrophytes SM-110 and C. albicans ATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively. Efinaconazole has a potent in vitro activity against fungal pathogens including dermatophytes, Candida and Malassezia species.
  • HY-108485
    Damnacanthal

    Src Apoptosis Fungal Cancer Infection Inflammation/Immunology
    Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56 lck tyrosine kinase activity. Natural Damnacanthal inhibits p56 lck autophosphorylation and phosphorylation of exogenous substrates with IC50s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity against Candida albicans.
  • HY-B1324A
    Oxiconazole

    Ro 13-8996 free base

    Fungal Cytochrome P450 Antibiotic Cancer Infection
    Oxiconazole (Ro 13-8996) is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest.
  • HY-116686
    Inz-1

    Cytochrome P450 Fungal Infection
    Inz-1 is a potent and selective mitochondrial cytochrome bc1 inhibitor for yeast (IC50=8.092 μM) over humans (IC50=45.320 μM). Inz-1 reverses Fluconazole (HY-B0101) or other triazole antifungals’ resistance in the pathogenic fungus Candida albicans.
  • HY-B0847
    Propiconazole

    Fungal Reactive Oxygen Species Infection
    Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 µM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 µg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS).
  • HY-B2033S
    Pyrimethanil-13C,15N2

    Fungal Infection
    Pyrimethanil-13C,15N2 is the 13C-labeled and 15N-labeled Pyrimethanil. Pyrimethanil is an anilinopyrimidine and broad-spectrum contact fungicide for the control of Botrytis spp. on a wide variety of crops. Pyrimethanil inhibits the biosynthesis of methionine and other amino acids in Botrytis cinerea. Pyrimethanil can be used for the research of fungal diseases prevention on fruit, vegetable and ornamental plants with mold infection.
  • HY-B1324
    Oxiconazole nitrate

    Ro 13-8996

    Fungal Cytochrome P450 Antibiotic Cancer Infection
    Oxiconazole (Ro 13-8996) nitrate is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole nitrate is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole nitrate exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest.
  • HY-N1836
    3-Acetonyl-3-hydroxyoxindole

    3-Hydroxy-3-acetonyloxindole

    Others Infection
    3-Acetonyl-3-hydroxyoxindole (AHO) is a potent systemic acquired resistance (SAR) inducer in plants. 3-Acetonyl-3-hydroxyoxindole induces resistance in tobacco plants against infection with tobacco mosaic virus (TMV) and the fungal pathogen Erysiphe cichoracearum. 3-Acetonyl-3-hydroxyoxindole increases the level of pathogenesis-related gene 1 (PR-1) expression, salicylic acid (SA) accumulation and phenylalanine ammonia-lyase activity.
  • HY-108485S
    Damnacanthal-d3

    Src Apoptosis Fungal Cancer Infection Inflammation/Immunology
    Damnacanthal-d3 is the deuterium labeled Damnacanthal. Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56 lck tyrosine kinase activity. Natural Damnacanthal inhibits p56 lck autophosphorylation and phosphorylation of exogenous substrates with IC50s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity against Candida albicans.
  • HY-122815
    Fusicoccin

    Fusicoccin A

    Apoptosis Cancer
    Fusicoccin (Fusicoccin A), a fungal pytotoxin, is a stabilizer of specific 14-3-3 protein-protein interactions. Fusicoccin sabilizes H +-ATPase/14-3-3 cmplex in pants, maintaining the enzyme in activated state. Fusicoccin also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif (a mode 3 motif), such as ERα, GPIbα, TASK3, CTFR, and p53. Fusicoccin induces apoptosis in cancer cells and has anticancer activity.
  • HY-B0847S1
    Propiconazole-d3 nitrate

    Fungal Reactive Oxygen Species Infection
    Propiconazole-d3 nitrate is the deuterium labeled Propiconazole nitrate. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 µM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 µg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS).
  • HY-B0847S
    Propiconazole-d7

    Fungal Reactive Oxygen Species Infection
    Propiconazole-d7 is the deuterium labeled Propiconazole. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 µM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 µg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS).
  • HY-B0845
    Prochloraz

    BTS 40542

    Fungal Estrogen Receptor/ERR Androgen Receptor Aryl Hydrocarbon Receptor Infection
    Prochloraz is an imidazole antifungal that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death. Prochloraz inhibits human placenta microsomal aromatase in vitro (IC50=40 nM). Prochloraz also acts as an antagonist of the estrogen receptor (ER) and androgen receptor (AR) (IC50s=25 μM and 4 μM, respectively) as well as activates the aryl hydrocarbon receptor (AhR; EC50=1 μM).
  • HY-144643
    CYP51/HDAC-IN-1

    Fungal HDAC Cytochrome P450 Inflammation/Immunology
    CYP51/HDAC-IN-1 is a potent, orally active CYP51/HDAC dual inhibitor. CYP51/HDAC-IN-1 inhibits important virulence factors and down-regulated resistance-associated genes. CYP51/HDAC-IN-1 exhibits potent therapeutic effects for both tropical candidiasis and cryptococcal meningitis.
  • HY-B0850
    Difenoconazole

    Fungal Infection
    Difenoconazole is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death. Difenoconazole inhibits the growth of F. graminearum isolates in vitro (EC50s=1.69-19.6 mg/L for mycelial growth). Difenoconazole also inhibits growth of A. sonali, F. fulva, B. cinerea, and R. solani (EC50s=0.131, 0.069, 0.297, and 0.252 mg/L, respectively).
  • HY-N2071
    Cedrol

    (+)-Cedrol; α-Cedrol

    Cytochrome P450 Fungal Infection Inflammation/Immunology Cancer
    Cedrol is a bioactive sesquiterpene, a potent competitive inhibitor of cytochrome P-450 (CYP) enzymes. Cedrol inhibits CYP2B6-mediated bupropion hydroxylase and CYP3A4-mediated midazolam hydroxylation with Ki of 0.9 μM and 3.4 μM, respectively. Cedrol also has weak inhibitory effect on CYP2C8, CYP2C9, and CYP2C19 enzymes. Cedrol is found in cedar essential oil and poetesses anti-septic, anti-inflammatory, anti-spasmodic, tonic, astringent, diuretic, insecticidal, and anti-fungal activities.
  • HY-B0846
    Dimethomorph

    Fungal Androgen Receptor Parasite Infection
    Dimethomorph is a morpholine fungicide that inhibits fungal cell wall formation. Dimethomorph inhibits mycelial growth of the oomycete fungi, P. citrophthora, P. parasitica, P. capsici, and P. infestans (EC50s=0.1, 0.38, <0.1, and 0.16-0.3 µg/mL, respectively), but is less active against the green algae species C. vulgaris or S. obliquus in vitro (EC50s=47.46 and 44.87 µg/mL, respectively). Dimethomorph inhibits androgen receptor (AR) activity in a reporter assay in MDA-kb2 human breast cancer cells but not in a yeast antiandrogen screen (IC20s=0.263 and 38.5 µM, respectively).